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Tytuł:
Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice.
Autorzy:
Du Y; Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Institutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui, 230601, China.
Gao F; Key Laboratory of Xin'an Medicine, the Ministry of Education and Key Laboratory of Molecular Biology (Brain diseases), Anhui University of Chinese Medicine, Hefei, 230012, China.
Sun H; Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Institutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui, 230601, China.
Wu C; School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. Electronic address: .
Zhu G; Key Laboratory of Xin'an Medicine, the Ministry of Education and Key Laboratory of Molecular Biology (Brain diseases), Anhui University of Chinese Medicine, Hefei, 230012, China. Electronic address: .
Zhu M; Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Institutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui, 230601, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115855. Date of Electronic Publication: 2023 Oct 11.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/pharmacology
Pyrimidines*/chemistry
Depressive Disorder*
Mice ; Animals ; Allosteric Regulation ; Structure-Activity Relationship ; Central Nervous System ; Receptors, G-Protein-Coupled
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.
Autorzy:
El-Kalyoubi S; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
El-Sebaey SA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Rashad AM; Accelerator and Ion Sources Department, Nuclear Research Center, Atomic Energy Authority, Cairo, Egypt.; Central Lab for Elemental and Isotopic Analysis, NRC, Atomic Energy Authority, Cairo, Egypt.
Al-Ghulikah HA; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Ghorab MM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Elfeky SM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2198163.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/chemical synthesis
Pyrimidines*/pharmacology
Topoisomerase II Inhibitors*/chemical synthesis
Topoisomerase II Inhibitors*/pharmacology
HSP90 Heat-Shock Proteins*/antagonists & inhibitors
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/pharmacology
Hep G2 Cells ; A549 Cells ; MCF-7 Cells ; Humans ; Cell Proliferation/drug effects ; Gene Expression Regulation/drug effects ; Cell Cycle/drug effects ; Computer Simulation
Czasopismo naukowe
Szczegóły
Tytuł:
Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3- d ]pyrimidine Analogues Bearing Deuterated Methylene Linkers as Potent KRAS Inhibitors.
Autorzy:
Xiao X; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai 200240, China.
Feng J; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Ma J; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
Xia X; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Liu X; Southern Medical University Affiliated Fengxian Hospital, The Third School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Zhang J; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; Lingang Laboratory, Shanghai 200210,China.
Ding C; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai 200240, China.
Pang X; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Zhang A; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; Lingang Laboratory, Shanghai 200210,China.; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai 200240, China.; National Key Laboratory of Innovative Immunotherapy, Shanghai 200240, China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Nov 23; Vol. 66 (22), pp. 15524-15549. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins p21(ras)*
Pyrimidines*/pharmacology
Pyrimidines*/therapeutic use
Mice ; Humans ; Animals ; Mutation
Czasopismo naukowe
Szczegóły
Tytuł:
Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity.
Autorzy:
El-Damasy AK; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Jin H; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Park JW; Center for Supercomputing Applications, Div. of National Supercomputing R&D, Korea Institute of Science and Technology Information, Daejeon, Republic of Korea.
Kim HJ; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Khojah H; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Seo SH; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Lee JH; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Bang EK; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Keum G; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2189097.
Typ publikacji:
Journal Article
MeSH Terms:
Fusion Proteins, bcr-abl*/genetics
Pyrimidines*/pharmacology
Imatinib Mesylate/pharmacology ; Piperazines/pharmacology ; Benzamides/pharmacology ; Apoptosis
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of Pyrazolo[1,5-a]pyrimidine derivative as a potent and selective PI3Kγ/δ dual inhibitor.
Autorzy:
Liang X; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Deng M; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
Zou F; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Qi Z; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Wang C; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
Liu J; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Liu Q; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Wang B; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Qi S; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Ge J; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
Yu H; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
Wang A; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Liu Q; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China; Precision Medicine Research Laboratory of Anhui Province, Hefei, Anhui, 230088, PR China.
Liu J; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China; Precision Medicine Research Laboratory of Anhui Province, Hefei, Anhui, 230088, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 15; Vol. 260, pp. 115768. Date of Electronic Publication: 2023 Sep 01.
Typ publikacji:
Journal Article
MeSH Terms:
Leukocytes*
Pyrimidines*/pharmacology
Animals ; Humans ; Rats ; Disease Models, Animal ; Macrophages ; Phenotype
Czasopismo naukowe
Szczegóły
Tytuł:
Structural optimization of pyrrolopyrimidine BTK inhibitors based on molecular simulation.
Autorzy:
Wu J; Pharmacy Department, Langzhong People's Hospital, Nanchong, China.
Li P; Pharmacy Department, Langzhong People's Hospital, Nanchong, China.
Chen X; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.; Chongqing Key Laboratory of Screening and Activity Evaluation of Targeted Drugs, Chongqing, China.
Liu R; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.; Chongqing Key Laboratory of Screening and Activity Evaluation of Targeted Drugs, Chongqing, China.
Mu Y; Pharmacy Department, Langzhong People's Hospital, Nanchong, China.
Shen Y; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.; Chongqing Key Laboratory of Screening and Activity Evaluation of Targeted Drugs, Chongqing, China.
Cheng X; Pharmacy Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shu M; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.; Chongqing Key Laboratory of Screening and Activity Evaluation of Targeted Drugs, Chongqing, China.
Bai Y; Pharmacy Department, Langzhong People's Hospital, Nanchong, China. .
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Źródło:
Journal of molecular modeling [J Mol Model] 2023 Nov 11; Vol. 29 (12), pp. 367. Date of Electronic Publication: 2023 Nov 11.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Pyrimidines*/pharmacology
Molecular Docking Simulation ; Reproducibility of Results ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Tofacitinib as a biologic response modifier in VEXAS syndrome: A case series.
Autorzy:
Salehi T; Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
Callisto A; Central Adelaide Local Health Network, Adelaide, South Australia, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Beecher MB; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Hissaria P; Central Adelaide Local Health Network, Adelaide, South Australia, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
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Źródło:
International journal of rheumatic diseases [Int J Rheum Dis] 2023 Nov; Vol. 26 (11), pp. 2340-2343. Date of Electronic Publication: 2023 Jun 19.
Typ publikacji:
Letter
MeSH Terms:
Piperidines*/adverse effects
Pyrimidines*/adverse effects
Humans ; Immunologic Factors ; Mutation
SCR Disease Name:
VEXAS syndrome
Opinia redakcyjna
Szczegóły
Tytuł:
In vitro and in silico evaluation of new thieno[2,3-d]pyrimidines as anti-cancer agents and apoptosis inducers targeting VEGFR-2.
Autorzy:
El-Metwally SA; Department of Basic Science, Higher Technological institute, 10th of Ramadan City, Egypt.
Abuelkhir AA; Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Taghour MS; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Cairo 12613, Egypt.
Husein DZ; Chemistry Department, Faculty of Science, New Valley University, El-Kharja 72511, Egypt.
Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Sultan A; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Ismail A; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
Elkhawaga SY; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia. Electronic address: .
Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt. Electronic address: .
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: .
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Źródło:
Computational biology and chemistry [Comput Biol Chem] 2023 Oct; Vol. 106, pp. 107928. Date of Electronic Publication: 2023 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/pharmacology
Antineoplastic Agents*/pharmacology
Apoptosis ; Cell Line ; Drug Design
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy.
Autorzy:
Chen S; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Chen Z; School of Life Sciences and Health Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China.
Lu L; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Zhao Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Zhou R; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Xie Q; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Shu Y; Shanghai Meizer Pharmaceuticals Co., Ltd, 58 Yuanmei Road, Shanghai, 201109, China.
Lin J; School of Life Sciences and Health Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China.
Yu X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China. Electronic address: .
Wang Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jul 05; Vol. 255, pp. 115403. Date of Electronic Publication: 2023 Apr 20.
Typ publikacji:
Journal Article
MeSH Terms:
Proteolysis Targeting Chimera*
Pyrimidines*/pharmacology
Pyrimidines*/chemistry
Humans ; Agammaglobulinaemia Tyrosine Kinase ; Structure-Activity Relationship ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression.
Autorzy:
Grotehans N; Max Planck Institute for Biology of Ageing, Cologne, Germany.
McGarry L; The CRUK Beatson Institute, Glasgow, UK.
Nolte H; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Xavier V; The CRUK Beatson Institute, Glasgow, UK.
Kroker M; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Narbona-Pérez ÁJ; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Deshwal S; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Giavalisco P; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Langer T; Max Planck Institute for Biology of Ageing, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
MacVicar T; The CRUK Beatson Institute, Glasgow, UK.
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Źródło:
The EMBO journal [EMBO J] 2023 Sep 18; Vol. 42 (18), pp. e113256. Date of Electronic Publication: 2023 Jul 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Mitochondrial*
Pyrimidines*/metabolism
Mitochondria/genetics ; Mitochondria/metabolism ; Nucleotides ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Ribonucleotides/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
CNS demyelination associated with nilotinib.
Autorzy:
Erturul E; Department of Neurology, Gazi University School of Medicine, Ankara, Turkey. .
Kocer B; Department of Neurology, Gazi University School of Medicine, Ankara, Turkey.
Gokce S; Department of Neurology, Gazi University School of Medicine, Ankara, Turkey.
Ucar M; Department of Radiology, Gazi University School of Medicine, Ankara, Turkey.
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Źródło:
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 Sep; Vol. 44 (9), pp. 3335-3339. Date of Electronic Publication: 2023 May 03.
Typ publikacji:
Letter
MeSH Terms:
Demyelinating Diseases*/chemically induced
Demyelinating Diseases*/diagnostic imaging
Pyrimidines*/adverse effects
Humans
Opinia redakcyjna
Szczegóły
Tytuł:
Purifying selection against spurious splicing signals contributes to the base composition evolution of the polypyrimidine tract.
Autorzy:
Yıldırım B; Department of Biomedical Sciences, Vetmeduni Vienna, Vienna, Austria.; Vienna Graduate School of Population Genetics, Vienna, Austria.
Vogl C; Department of Biomedical Sciences, Vetmeduni Vienna, Vienna, Austria.; Vienna Graduate School of Population Genetics, Vienna, Austria.
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Źródło:
Journal of evolutionary biology [J Evol Biol] 2023 Sep; Vol. 36 (9), pp. 1295-1312. Date of Electronic Publication: 2023 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
RNA Splicing*
Pyrimidines*/metabolism
Base Sequence ; Base Composition ; Mutation ; Introns
Czasopismo naukowe
Szczegóły
Tytuł:
Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases.
Autorzy:
Yang CS; Genomics BioSci & Tech Co. Ltd., New Taipei, 221, Taiwan.
Ko TP; Institute of Biological Chemistry, Academia Sinica, Taipei, 115, Taiwan.
Chen CJ; Graduate Institute of Integrated Medicine, China Medical University, Taichung, 406, Taiwan.; Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, 404, Taiwan.
Hou MH; Genomics BioSci & Tech Co. Ltd., New Taipei, 221, Taiwan.
Wang YC; Trade Wind Biotech Co. Ltd., Taipei, 115, Taiwan.
Chen Y; Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, 402, Taiwan. .
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Źródło:
Nature communications [Nat Commun] 2023 Aug 21; Vol. 14 (1), pp. 5078. Date of Electronic Publication: 2023 Aug 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyrimidines*
Nucleotidyltransferases*/genetics
Nucleotides ; Chromogranin A ; Purine Nucleotides
Czasopismo naukowe
Szczegóły
Tytuł:
Gastrointestinal: Diarrhea in a patient treated with pazopanib: A rare case of a common adverse effect.
Autorzy:
Wu K; St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
MacIsaac M; St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
Connell W; St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
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Źródło:
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2023 Aug; Vol. 38 (8), pp. 1242. Date of Electronic Publication: 2023 Jan 15.
Typ publikacji:
Case Reports; Journal Article; Review
MeSH Terms:
Pyrimidines*/adverse effects
Kidney Neoplasms*/drug therapy
Humans ; Diarrhea/chemically induced ; Gastrointestinal Tract ; Indazoles/therapeutic use ; Angiogenesis Inhibitors/adverse effects
Czasopismo naukowe
Szczegóły
Tytuł:
Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi-heart study.
Autorzy:
Chung SM; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Moon JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Hong JH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Eulji University Hospital, School of Medicine, Daejeon, Republic of Korea.
Hwang IC; Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Lim S; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
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Źródło:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Aug; Vol. 25 (8), pp. 2181-2190. Date of Electronic Publication: 2023 May 03.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/drug therapy
Piperidones*/therapeutic use
Pyrimidines*/therapeutic use
Hypoglycemic Agents*/therapeutic use
Sulfonylurea Compounds*/therapeutic use
Heart*/drug effects
Metformin ; Humans ; Echocardiography ; Prospective Studies ; Male ; Female ; Middle Aged ; Aged
Czasopismo naukowe
Szczegóły
Tytuł:
Pediatric DDR inhibitor combinations: Are WEE1 there yet?
Autorzy:
Slotkin EK; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ortiz MV; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Glade Bender JL; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
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Źródło:
Cancer [Cancer] 2023 Jul 15; Vol. 129 (14), pp. 2132-2134. Date of Electronic Publication: 2023 Apr 20.
Typ publikacji:
Editorial
MeSH Terms:
Pyrimidines*
Pyrimidinones*/pharmacology
Humans ; Child ; DNA Damage ; Cell Cycle Proteins ; Cell Line, Tumor ; Protein-Tyrosine Kinases
Opinia redakcyjna
Szczegóły
Tytuł:
Visible-Light-Mediated Regioselective C3-H Selenylation of Pyrazolo[1,5- a ]pyrimidines Using Erythrosine B as Photocatalyst.
Autorzy:
Choudhuri T; Department of Chemistry, University of Kalyani, Kalyani 741235, India.
Paul S; Department of Chemistry, University of Kalyani, Kalyani 741235, India.
Das S; Department of Chemistry, University of Kalyani, Kalyani 741235, India.
Pathak DD; Department of Chemistry & Chemical Biology, Indian Institute of Technology (ISM), Dhanbad 826 004, India.
Bagdi AK; Department of Chemistry, University of Kalyani, Kalyani 741235, India.
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Źródło:
The Journal of organic chemistry [J Org Chem] 2023 Jul 07; Vol. 88 (13), pp. 8992-9003. Date of Electronic Publication: 2023 Jun 11.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/pharmacology
Erythrosine*
Solvents
Czasopismo naukowe
Szczegóły
Tytuł:
Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids.
Autorzy:
Cesari E; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.; GSTeP Organoids Research Core Facility, IRCCS Fondazione Policlinico A. Gemelli, 00168, Rome, Italy.
Ciucci A; GSTeP Organoids Research Core Facility, IRCCS Fondazione Policlinico A. Gemelli, 00168, Rome, Italy.; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.
Pieraccioli M; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.; GSTeP Organoids Research Core Facility, IRCCS Fondazione Policlinico A. Gemelli, 00168, Rome, Italy.
Caggiano C; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.; GSTeP Organoids Research Core Facility, IRCCS Fondazione Policlinico A. Gemelli, 00168, Rome, Italy.
Nero C; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.; Department of Woman and Child Health and Public Health, Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito 1, 00168, Rome, Italy.
Bonvissuto D; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.
Sillano F; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.
Buttarelli M; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.; Unit of Translational Medicine for Woman and Child Health, IRCCS Fondazione Policlinico Universitario A. Gemelli, 00168, Rome, Italy.
Piermattei A; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.
Loverro M; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.; Department of Woman and Child Health and Public Health, Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito 1, 00168, Rome, Italy.
Camarda F; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.; Department of Woman and Child Health and Public Health, Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito 1, 00168, Rome, Italy.
Greco V; Department of Diagnostic and Laboratory Medicine, Unity of Chemistry, Biochemistry and Clinical Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics Research, Catholic University of the Sacred Heart, Università Cattolica del Sacro Cuore, Rome, Italy.
De Bonis M; Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics Research, Catholic University of the Sacred Heart, Università Cattolica del Sacro Cuore, Rome, Italy.
Minucci A; Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics Research, Catholic University of the Sacred Heart, Università Cattolica del Sacro Cuore, Rome, Italy.
Gallo D; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.; Unit of Translational Medicine for Woman and Child Health, IRCCS Fondazione Policlinico Universitario A. Gemelli, 00168, Rome, Italy.
Urbani A; Department of Diagnostic and Laboratory Medicine, Unity of Chemistry, Biochemistry and Clinical Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics Research, Catholic University of the Sacred Heart, Università Cattolica del Sacro Cuore, Rome, Italy.
Vizzielli G; Department of Medical Area (DAME), University of Udine, Udine, Italy.; Clinic of Obstetrics and Gynecology, 'Santa Maria Della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Scambia G; Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy. .; Department of Woman and Child Health and Public Health, Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito 1, 00168, Rome, Italy. .
Sette C; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy. .; GSTeP Organoids Research Core Facility, IRCCS Fondazione Policlinico A. Gemelli, 00168, Rome, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 May 18; Vol. 42 (1), pp. 126. Date of Electronic Publication: 2023 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Pyrimidines*/pharmacology
Pyrimidines*/therapeutic use
Female ; Humans ; Anilides/pharmacology ; Anilides/therapeutic use ; CDC2 Protein Kinase/metabolism ; Cyclin-Dependent Kinases/genetics ; Organoids/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Base-Promoted [5 + 1 + 3] Cascade Cyclization of o -Nitrochalcones, Elemental Sulfur, and Guanidine to Benzo[4,5]thieno[3,2- d ]pyrimidine Frameworks.
Autorzy:
Wan J; National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China.
Huang S; National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China.
Zhang Z; National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China.
Wu Q; National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China.
Wang Z; National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China.
Huang C; National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China.
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Źródło:
Organic letters [Org Lett] 2023 Jun 23; Vol. 25 (24), pp. 4451-4455. Date of Electronic Publication: 2023 Jun 09.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*
Guanidines*
Guanidine ; Cyclization ; Sulfur
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis and biological evaluation of pyrrolopyrimidine derivatives as novel and selective positive modulator of the small conductance Ca channels.
Autorzy:
Guo R; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Cui M; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Li X; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Wu M; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Xu F; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Wang C; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Feng P; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Wang J; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Huo S; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Luo Z; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Xing R; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Gu J; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Shi X; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China. Electronic address: .
Liu Y; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, 050017, PR China; Hebei Province Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, PR China. Electronic address: .
Wang L; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China; Hebei Province Key Laboratory of Innovative Drug Research and Evaluation, Shijiazhuang, 050017, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jun 05; Vol. 254, pp. 115353. Date of Electronic Publication: 2023 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Small-Conductance Calcium-Activated Potassium Channels*/metabolism
Pyrimidines*/pharmacology
Molecular Docking Simulation ; Pyrroles/pharmacology
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 42138

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