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Tytuł:
Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors.
Autorzy:
Song S; School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou, 510632, China.
Tang H; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zuchongzhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China.
Ran T; Division of Drug and Vaccine Research, Guangzhou Laboratory, Guangzhou, 510530, China.
Fang F; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zuchongzhi Road, Shanghai, 201203, China.
Tong L; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zuchongzhi Road, Shanghai, 201203, China.
Chen H; Division of Drug and Vaccine Research, Guangzhou Laboratory, Guangzhou, 510530, China. Electronic address: chen_.
Xie H; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zuchongzhi Road, Shanghai, 201203, China; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Cuiheng New District, Zhongshan City, China. Electronic address: .
Lu X; School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou, 510632, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Feb 05; Vol. 247, pp. 115034. Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*
Pyrimidines*/pharmacology
Pyrimidines*/chemistry
Humans ; Structure-Activity Relationship ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Protein Serine-Threonine Kinases
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis and biological activity evaluation of novel 3,5,7-trisubstituted pyrazolo[1,5-a]pyrimidines.
Autorzy:
Vlková K; Department of Experimental Biology, Palacký University, Šlechtitelů 241/27, CZ 783 71 Olomouc, Czech Republic.
Padrtová R; Department of Experimental Biology, Palacký University, Šlechtitelů 241/27, CZ 783 71 Olomouc, Czech Republic.
Gucký T; Department of Experimental Biology, Palacký University, Šlechtitelů 241/27, CZ 783 71 Olomouc, Czech Republic. Electronic address: .
Peřina M; Department of Experimental Biology, Palacký University, Šlechtitelů 241/27, CZ 783 71 Olomouc, Czech Republic.
Řezníčková E; Department of Experimental Biology, Palacký University, Šlechtitelů 241/27, CZ 783 71 Olomouc, Czech Republic.
Kryštof V; Department of Experimental Biology, Palacký University, Šlechtitelů 241/27, CZ 783 71 Olomouc, Czech Republic.
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jan 15; Vol. 80, pp. 129096. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/chemistry
Leukemia, Myeloid, Acute*/drug therapy
Humans ; Cell Line, Tumor ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemistry ; Mutation ; fms-Like Tyrosine Kinase 3/genetics ; Apoptosis ; Cell Proliferation
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis and Molecular Docking Study of Novel Pyrimidine Derivatives against COVID-19.
Autorzy:
Alamshany ZM; Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21551, Saudi Arabia.
Khattab RR; Photochemistry Department (Synthetic Unit), National Research Centre, Dokki, Giza 12622, Egypt.
Hassan NA; Photochemistry Department (Synthetic Unit), National Research Centre, Dokki, Giza 12622, Egypt.
El-Sayed AA; Photochemistry Department (Synthetic Unit), National Research Centre, Dokki, Giza 12622, Egypt.
Tantawy MA; Hormones Department, National Research Centre, Dokki, Giza 12622, Egypt.
Mostafa A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, Giza 12622, Egypt.
Hassan AA; Chemistry Department, Faculty of Science, Suez University, Suez 43221, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 11; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Antiviral Agents*/pharmacology
Pyrimidines*/pharmacology
Pyrimidines*/chemistry
SARS-CoV-2*/drug effects
Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis and biological evaluation of a new class of 7H-pyrrolo[2,3-d]pyrimidine derivatives as Mps1 inhibitors for the treatment of breast cancer.
Autorzy:
Li X; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wei W; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Tao L; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zeng J; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhu Y; Department of Clinical Pharmacy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, China.
Yang T; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wang Q; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Tang M; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Liu Z; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: .
Yu L; Laboratory of Emergency Medicine, Department of Emergency Medicine, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114887. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Breast Neoplasms*/drug therapy
Protein Kinase Inhibitors*/chemistry
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/therapeutic use
Protein Serine-Threonine Kinases*/antagonists & inhibitors
Pyrimidines*/chemistry
Pyrimidines*/pharmacology
Pyrimidines*/therapeutic use
Female ; Humans ; Cell Cycle Proteins ; Protein-Tyrosine Kinases ; Cell Line, Tumor ; Drug Design
Czasopismo naukowe
Szczegóły
Tytuł:
Diarylation of thiazolopyrimidines by laccase and their in vitro evaluation as antitumor agents.
Autorzy:
Shahedi M; Department of Organic and Inorganic Chemistry, Faculty of Chemistry, Shahid Beheshti University, G.C., Tehran, Iran.
Shahani R; Department of Organic and Inorganic Chemistry, Faculty of Chemistry, Shahid Beheshti University, G.C., Tehran, Iran.
Habibi Z; Department of Organic and Inorganic Chemistry, Faculty of Chemistry, Shahid Beheshti University, G.C., Tehran, Iran. Z_.
Yousefi M; Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. .
Brask J; Novozymes A/S, Krogshøjvej 36, Bagsværd, 2880, Copenhagen, Denmark.
Minaei-Tehrani A; Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Samadi FY; Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Mohammadi M; Bioprocess Engineering Department, Institute of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
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Źródło:
Scientific reports [Sci Rep] 2022 Dec 25; Vol. 12 (1), pp. 22326. Date of Electronic Publication: 2022 Dec 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Drug Screening Assays, Antitumor*
Laccase*/chemistry
Thiazoles*/chemistry
Thiazoles*/pharmacology
Pyrimidines*/chemistry
Pyrimidines*/pharmacology
Humans ; Cell Proliferation/drug effects ; Hep G2 Cells ; HT29 Cells ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation.
Autorzy:
Chaudhary CL; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Lim D; Innovo Therapeutics Inc, Daejeon, Republic of Korea.
Chaudhary P; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Guragain D; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Park HD; Innovo Therapeutics Inc, Daejeon, Republic of Korea.
Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 844-856.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Chickens ; Dose-Response Relationship, Drug ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Models, Molecular ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action.
Autorzy:
Ruzi Z; Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China; University of Chinese Academy of Sciences, Yuquan Rd 19 A, Beijing 100049, PR China.
Bozorov K; Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China; Faculty of Chemistry, Samarkand State University, University blv. 15, Samarkand 140104, Uzbekistan.
Nie L; Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China.
Zhao J; Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China.
Aisa HA; Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China; University of Chinese Academy of Sciences, Yuquan Rd 19 A, Beijing 100049, PR China. Electronic address: .
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Dec; Vol. 156, pp. 113948. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/pharmacology
Pyrimidines*/chemistry
Antineoplastic Agents*/therapeutic use
Mice ; Animals ; Humans ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Tubulin/metabolism ; Vascular Endothelial Growth Factor A ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors.
Autorzy:
Yan L; School of Pharmaceutical Sciences, Guizhou University, Guiyang, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.; Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, China.
Wang Q; School of Pharmaceutical Sciences, Guizhou University, Guiyang, China.; Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, China.
Liu L; School of Pharmaceutical Sciences, Guizhou University, Guiyang, China.; Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, China.
Le Y; School of Pharmaceutical Sciences, Guizhou University, Guiyang, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.; Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 832-843.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Aniline Compounds/*pharmacology
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Design, synthesis, and biological evaluation of new thieno[2,3- d ] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study.
Autorzy:
Elmenier FM; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Cairo, Egypt.
Lasheen DS; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Cairo, Egypt.
Abouzid KAM; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Cairo, Egypt.; Faculty of Pharmacy, Department of Organic and Medicinal Chemistry, University of Sadat City, Menoufia, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 315-332.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Antineoplastic Agents/*pharmacology
Phosphatidylinositol 3-Kinases/*metabolism
Phosphoinositide-3 Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Phosphoinositide-3 Kinase Inhibitors/chemical synthesis ; Phosphoinositide-3 Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.
Autorzy:
Devos T; Department of Hematology, University Hospitals Leuven (UZ Leuven) and Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega Institute), Catholic University Leuven (KU Leuven), Leuven, Belgium.
Selleslag D; Department of Hematology, Algemeen Ziekenhuis Sint-Jan, Bruges, Belgium.
Granacher N; Department of Hematology, Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium.
Havelange V; Department of Hematology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Benghiat FS; Department of Hemato-Oncology, Erasme Hospital, Brussels, Belgium.
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Źródło:
Hematology (Amsterdam, Netherlands) [Hematology] 2022 Dec; Vol. 27 (1), pp. 23-31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Molecular Targeted Therapy*/methods
Janus Kinase Inhibitors/*therapeutic use
Nitriles/*therapeutic use
Primary Myelofibrosis/*drug therapy
Pyrazoles/*therapeutic use
Pyrimidines/*therapeutic use
Biomarkers ; Clinical Decision-Making ; Combined Modality Therapy/methods ; Disease Management ; Disease Susceptibility ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/etiology ; Drug-Related Side Effects and Adverse Reactions/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Janus Kinase Inhibitors/administration & dosage ; Janus Kinase Inhibitors/adverse effects ; Nitriles/administration & dosage ; Nitriles/adverse effects ; Platelet Count ; Primary Myelofibrosis/diagnosis ; Primary Myelofibrosis/etiology ; Prognosis ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo[3,4-d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study.
Autorzy:
Salem IM; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. Electronic address: Dr_Ibrahim_.
Mostafa SM; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Salama I; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
El-Sabbagh OI; Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
A H Hegazy W; Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt; Pharmacy Program, Department of Pharmaceutical Sciences, Oman College of Health Sciences, Muscat 113, Oman.
Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 Dec; Vol. 129, pp. 106207. Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Pyrimidines*/chemical synthesis
Pyrimidines*/chemistry
Pyrimidines*/pharmacology
Tetrahydrofolate Dehydrogenase*/metabolism
Folic Acid Antagonists*/chemical synthesis
Folic Acid Antagonists*/chemistry
Folic Acid Antagonists*/pharmacology
Pyrazoles*/chemical synthesis
Pyrazoles*/chemistry
Pyrazoles*/pharmacology
Female ; Humans ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Microwave-assisted one-pot multicomponent synthesis of steroidal pyrido[2,3-d]pyrimidines and their possible implications in drug development.
Autorzy:
Khan A; Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202 002, UP, India.
Alam MT; Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh 202 002, UP, India.
Iqbal A; Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202 002, UP, India.
Siddiqui T; Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202 002, UP, India.
Ali A; Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202 002, UP, India. Electronic address: .
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Źródło:
Steroids [Steroids] 2023 Feb; Vol. 190, pp. 109154. Date of Electronic Publication: 2022 Dec 12.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*
Microwaves*
Humans ; Molecular Docking Simulation ; Protein Aggregates ; Steroids/chemistry ; Drug Development
Czasopismo naukowe
Szczegóły
Tytuł:
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.
Autorzy:
Schröder M; SGC Frankfurt, Goethe University Frankfurt, Buchmann Institute for Life Sciences (BMLS), Riedberg Campus, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Leiendecker M; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
Grädler U; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
Braun J; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
Blum A; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
Wanior M; SGC Frankfurt, Goethe University Frankfurt, Buchmann Institute for Life Sciences (BMLS), Riedberg Campus, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.
Berger BT; SGC Frankfurt, Goethe University Frankfurt, Buchmann Institute for Life Sciences (BMLS), Riedberg Campus, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Krämer A; SGC Frankfurt, Goethe University Frankfurt, Buchmann Institute for Life Sciences (BMLS), Riedberg Campus, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Müller S; SGC Frankfurt, Goethe University Frankfurt, Buchmann Institute for Life Sciences (BMLS), Riedberg Campus, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Esdar C; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
Knapp S; SGC Frankfurt, Goethe University Frankfurt, Buchmann Institute for Life Sciences (BMLS), Riedberg Campus, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Heinrich T; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 837-854. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Serine-Threonine Kinases*
Pyrimidines*/pharmacology
Phosphorylation ; Benzimidazoles/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects.
Autorzy:
Song Z; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Lou L; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Fan G; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Liu L; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Ge Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Liu H; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Chan ASC; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Zhang X; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China. Electronic address: .
Xiong XF; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114907. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins p21(ras)*/genetics
Pyrimidines*/pharmacology
Humans ; Piperazine ; Antihypertensive Agents ; Cell Proliferation
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses.
Autorzy:
Wang R; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhai G; Shanghai HighsLab Therapeutics. Inc., Shanghai 201203, China.
Zhu G; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wang M; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Gong X; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, China.
Zhang W; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Ge G; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
Chen H; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
Chen L; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 Jan; Vol. 130, pp. 106264. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
SARS-CoV-2*/enzymology
SARS-CoV-2*/metabolism
Quaternary Ammonium Compounds*/pharmacology
Pyrimidines*/pharmacology
Viral Protease Inhibitors*/pharmacology
COVID-19 Drug Treatment*
Humans ; Antiviral Agents/pharmacology ; Endopeptidases ; Molecular Docking Simulation ; Peptide Hydrolases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Stepwise synthesis of 2,6-difunctionalized ethyl pyrazolo[1,5- a ]pyrimidine-3-carboxylate via site-selective cross-coupling reactions: experimental and computational studies.
Autorzy:
Messaoudi C; Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l'Energie (PCM2E), EA 6299. Université de Tours, Faculté des Sciences et Techniques, Avenue Monge Faculté des Sciences, Parc de Grandmont, 37200 Tours, France. .; Laboratoire de Synthese Organique Sélective et Hétérocyclique-Evaluation de l'Activité Biologique, Faculté des Sciences de Tunis, Université de Tunis El Manar, Tunis 2092, Tunisia.
Jismy B; Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l'Energie (PCM2E), EA 6299. Université de Tours, Faculté des Sciences et Techniques, Avenue Monge Faculté des Sciences, Parc de Grandmont, 37200 Tours, France. .
Jacquemin J; Materials Science and Nano-Engineering (MSN) Department, Mohammed VI Polytechnic University (UM6P), Lot 660-Hay Moulay Rachid, Benguerir 43150, Morocco.
Allouchi H; Faculté de Pharmacie, Université de Tours, EA 7502 SIMBA, 31 Avenue Monge, 37200 Tours, France.
M'Rabet H; Laboratoire de Synthese Organique Sélective et Hétérocyclique-Evaluation de l'Activité Biologique, Faculté des Sciences de Tunis, Université de Tunis El Manar, Tunis 2092, Tunisia.
Abarbri M; Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l'Energie (PCM2E), EA 6299. Université de Tours, Faculté des Sciences et Techniques, Avenue Monge Faculté des Sciences, Parc de Grandmont, 37200 Tours, France. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Dec 14; Vol. 20 (48), pp. 9684-9697. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alkynes*
Pyrimidines*
Catalysis ; Carboxylic Acids
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases.
Autorzy:
Begum Z; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Ullah S; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
Akram M; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Uzair M; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
Ullah F; Department of Chemistry, Winnipeg University, Portage Ave, Winnipeg, MB, Canada.
Ahsanullah; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Pelletier J; Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada.
Sévigny J; Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada; Département de Microbiologie-Infectiologie et d'Immunologie, Faculté de Médecine, Université Laval, Québec City, QC, Canada.
Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan. Electronic address: .
Hassan A; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 Dec; Vol. 129, pp. 106196. Date of Electronic Publication: 2022 Oct 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Isoenzymes*
Pyrimidines*/pharmacology
Molecular Docking Simulation ; Structure-Activity Relationship ; Molecular Structure
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis and molecular docking of new fused 1 H -pyrroles, pyrrolo[3,2- d ]pyrimidines and pyrrolo[3,2- e ][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors.
Autorzy:
Belal A; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Abdel Gawad NM; Medicinal Chemistry Department, Faculty of Pharmacy, Cairo University, Giza, Egypt.
Mehany ABM; Department of Zoology, Faculty of Science, Al-Azhar University, Nasr City, Egypt.
Abourehab MAS; Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia, Egypt.
Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Al-Karmalawy AA; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University- Egypt, New Damietta, Egypt.
Ismael AS; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1884-1902.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Pyrimidines*/chemistry
Azepines/pharmacology ; Cell Proliferation ; Cyclin A1/metabolism ; Cyclin-Dependent Kinase 2/metabolism ; Drug Screening Assays, Antitumor ; ErbB Receptors/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors ; Protein Serine-Threonine Kinases ; Protein-Tyrosine Kinases ; Pyrroles/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Characterization of exposure-response relationships of ipatasertib in patients with metastatic castration-resistant prostate cancer in the IPATential150 study.
Autorzy:
Kotani N; Genentech, Inc., South San Francisco, CA, USA. .; Pharmaceutical Science Department, Chugai Pharmaceutical Co., Ltd., 1-1 Nihonbashi-Muromachi 2-Chome, Chuo-ku, Tokyo, 103-8324, Japan. .
Wilkins JJ; Occams Coöperatie UA, Amstelveen, The Netherlands.
Wade JR; Occams Coöperatie UA, Amstelveen, The Netherlands.
Dang S; Genentech, Inc., South San Francisco, CA, USA.
Sutaria DS; Genentech, Inc., South San Francisco, CA, USA.
Yoshida K; Genentech, Inc., South San Francisco, CA, USA.
Sundrani S; Genentech, Inc., South San Francisco, CA, USA.; Department of Bioengineering/Biomedical Computation, Stanford University, Stanford, CA, USA.
Ding H; Genentech, Inc., South San Francisco, CA, USA.
Garcia J; F. Hoffmann-La Roche AG, Basel, Switzerland.
Hinton H; F. Hoffmann-La Roche AG, Basel, Switzerland.
Sane R; Genentech, Inc., South San Francisco, CA, USA.
Chanu P; Department of Clinical Pharmacology, Genentech/Roche, Lyon, France.
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Źródło:
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2022 Dec; Vol. 90 (6), pp. 511-521. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Clinical Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Piperazines*/adverse effects
Prostatic Neoplasms, Castration-Resistant*/drug therapy
Prostatic Neoplasms, Castration-Resistant*/pathology
Pyrimidines*/adverse effects
Humans ; Male
Czasopismo naukowe
Szczegóły
Tytuł:
Jaktinib (JAK1/2 inhibitor): A momelotinib derivative with similar activity and optimized dosing schedule.
Autorzy:
Tefferi A; Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Gangat N; Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Pardanani A; Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
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Źródło:
American journal of hematology [Am J Hematol] 2022 Dec; Vol. 97 (12), pp. 1507-1509. Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Editorial
MeSH Terms:
Benzamides*
Pyrimidines*
Humans ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Janus Kinase 1
Opinia redakcyjna
Szczegóły
Wyświetlanie 1-20 z 41214

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