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Tytuł :
Effects of naringenin on the pharmacokinetics of tofacitinib in rats.
Autorzy :
Wang B; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Shen J; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Zhou Q; The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Meng D; School of Medicine, Yichun University, Yichun, China.
He Y; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Chen F; The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Wang S; The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.; School of Pharmaceutical Science, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Ji W; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 225-230.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacokinetics
Anti-Inflammatory Agents/*pharmacology
Flavanones/*pharmacology
Piperidines/*pharmacokinetics
Piperidines/*pharmacology
Pyrimidines/*pharmacokinetics
Pyrimidines/*pharmacology
Pyrroles/*pharmacokinetics
Pyrroles/*pharmacology
Administration, Oral ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Area Under Curve ; Arthritis, Rheumatoid/drug therapy ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Flavanones/administration & dosage ; Piperidines/administration & dosage ; Piperidines/blood ; Pyrimidines/administration & dosage ; Pyrimidines/blood ; Pyrroles/administration & dosage ; Pyrroles/blood ; Rats, Sprague-Dawley ; Signal-To-Noise Ratio
Czasopismo naukowe
Tytuł :
4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines.
Autorzy :
Hügle M; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 8, D-79104 Freiburg, Germany.; Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104 Freiburg, Germany.
Regenass P; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104 Freiburg, Germany.
Warstat R; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104 Freiburg, Germany.
Hau M; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, D-79104 Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Schänzlestr. 18, D-79104 Freiburg, Germany.
Schmidtkunz K; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, D-79104 Freiburg, Germany.
Lucas X; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 8, D-79104 Freiburg, Germany.
Wohlwend D; Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104 Freiburg, Germany.
Einsle O; Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104 Freiburg, Germany.
Jung M; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, D-79104 Freiburg, Germany.
Breit B; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104 Freiburg, Germany.
Günther S; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 8, D-79104 Freiburg, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 24; Vol. 63 (24), pp. 15603-15620. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Chromosomal Proteins, Non-Histone/*antagonists & inhibitors
Proteins/*antagonists & inhibitors
Pyrroles/*chemistry
Transcription Factors/*antagonists & inhibitors
Antineoplastic Agents/pharmacology ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromosomal Proteins, Non-Histone/metabolism ; Crystallography, X-Ray ; Humans ; Kinetics ; Ligands ; Molecular Dynamics Simulation ; Protein Domains ; Proteins/metabolism ; Pyrroles/metabolism ; Pyrroles/pharmacology ; Structure-Activity Relationship ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
In vitro screening and in silico prediction of antifungal metabolites from rhizobacterium Achromobacter kerstersii JKP9.
Autorzy :
Vijay K; Department of Microbiology, Science Campus, Alagappa University, Karaikudi, Tamilnadu, India.
Devi TS; Department of Microbiology, Science Campus, Alagappa University, Karaikudi, Tamilnadu, India.
Sree KK; Department of Microbiology, Science Campus, Alagappa University, Karaikudi, Tamilnadu, India.
Elgorban AM; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Kumar P; Department of Animal Health and Management, Science Campus, Alagappa University, Tamilnadu, Karaikudi, India.
Govarthanan M; Department of Environmental Engineering, Kyungpook National University, 41566, Daegu, Republic of Korea.
Kavitha T; Department of Microbiology, Science Campus, Alagappa University, Karaikudi, Tamilnadu, India. .
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Źródło :
Archives of microbiology [Arch Microbiol] 2020 Dec; Vol. 202 (10), pp. 2855-2864. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Achromobacter/*metabolism
Antifungal Agents/*pharmacology
Fungicides, Industrial/*pharmacology
Fusarium/*drug effects
Pyrroles/*pharmacology
Achromobacter/genetics ; Antifungal Agents/metabolism ; Lycopersicon esculentum/microbiology ; Molecular Docking Simulation ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Pyrroles/metabolism
SCR Organism :
Achromobacter kerstersii
Czasopismo naukowe
Tytuł :
Pharmacodynamics and pharmacokinetics of DWP14012 (fexuprazan) in healthy subjects with different ethnicities.
Autorzy :
Hwang JG; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
Jeon I; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
Park SA; Daewoong Pharmaceutical Co., Ltd., Seoul, Republic of Korea.
Lee A; Daewoong Pharmaceutical Co., Ltd., Seoul, Republic of Korea.
Yu KS; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
Jang IJ; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
Lee S; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
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Źródło :
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2020 Dec; Vol. 52 (11-12), pp. 1648-1657. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Amines/*administration & dosage
Gastric Acid/*metabolism
Pyrroles/*administration & dosage
Adult ; Amines/pharmacokinetics ; Amines/pharmacology ; Asian Continental Ancestry Group ; Double-Blind Method ; European Continental Ancestry Group ; Female ; Humans ; Male ; Pyrroles/pharmacokinetics ; Pyrroles/pharmacology ; Young Adult
Czasopismo naukowe
Tytuł :
ABBV-744 as a potential inhibitor of SARS-CoV-2 main protease enzyme against COVID-19.
Autorzy :
Fakhar Z; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO WITS, Johannesburg, 2050, South Africa.
Khan S; Department of Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.
AlOmar SY; Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Alkhuriji A; Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Ahmad A; Department of Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa. .; Infection Control, Charlotte Maxeke Johannesburg Academic Hospital, National Health Laboratory Service, Johannesburg, 2193, South Africa. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jan 08; Vol. 11 (1), pp. 234. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Protease Inhibitors/*pharmacology
Pyridines/*pharmacology
Pyrroles/*pharmacology
SARS-CoV-2/*drug effects
Antiviral Agents/therapeutic use ; COVID-19/virology ; Drug Repositioning ; Humans ; Molecular Docking Simulation ; Protease Inhibitors/therapeutic use ; Protein Binding ; Pyridines/therapeutic use ; Pyrroles/therapeutic use
Czasopismo naukowe
Tytuł :
Editorial: "Stardust gastric mucosa" - A novel and consistent marker of vonoprazan safety during follow-up?
Autorzy :
Luu M; CIC1432, Plurithematic Unit, INSERM, Dijon, France.; Clinical Investigation Center, Plurithematic Unit, Dijon-Bourgogne University Hospital, Dijon, France.
Ben Ghezala I; CIC1432, Plurithematic Unit, INSERM, Dijon, France.; Clinical Investigation Center, Plurithematic Unit, Dijon-Bourgogne University Hospital, Dijon, France.
Bardou M; CIC1432, Plurithematic Unit, INSERM, Dijon, France.; Clinical Investigation Center, Plurithematic Unit, Dijon-Bourgogne University Hospital, Dijon, France.; Gastroenterology Department, Bourgogne University Hospital, Dijon, France.
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Źródło :
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2021 Jan; Vol. 53 (1), pp. 196-197.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Gastric Mucosa*
Pyrroles*
Follow-Up Studies ; Humans ; Incidence ; Propensity Score ; Risk Factors ; Sulfonamides
Opinia redakcyjna
Tytuł :
Propensity score matching analysis: incidence and risk factors for "stardust" gastric mucosa, a novel gastric finding potentially induced by vonoprazan.
Autorzy :
Yoshizaki T; Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Morisawa T; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Fujinami M; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Matsuda T; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Katayama N; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Inoue K; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Matsumoto M; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Ikeoka S; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Takagi M; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Sako T; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Momose K; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Noda M; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Eguchi T; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Okada A; Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
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Źródło :
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2021 Jan; Vol. 53 (1), pp. 94-102. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Gastric Mucosa*
Pyrroles*/adverse effects
Female ; Humans ; Incidence ; Propensity Score ; Proton Pump Inhibitors/adverse effects ; Retrospective Studies ; Risk Factors ; Sulfonamides
Czasopismo naukowe
Tytuł :
Editorial: acid suppression with potassium-competitive acid blockers dismissing genotype concerns.
Autorzy :
Scarpignato C; Faculty of Health Sciences, LUdeS Lugano Campus, Lugano, Switzerland.; United Campus of Malta, Msida, Malta.; Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong.
Hunt RH; Division of Gastroenterology and Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada.
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Źródło :
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2021 Jan; Vol. 53 (1), pp. 187-188.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Potassium*
Pyrroles*
Amines ; Genotype ; Healthy Volunteers ; Humans
Opinia redakcyjna
Tytuł :
Comparison of the sensory properties of fragrant and non-fragrant rice (Oryza sativa), focusing on the role of the popcorn-like aroma compound 2-acetyl-1-pyrroline.
Autorzy :
Wei X; Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6AP, UK.
Sun Q; Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6AP, UK.
Methven L; Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6AP, UK. Electronic address: .
Elmore JS; Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6AP, UK. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Mar 01; Vol. 339, pp. 128077. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Taste*
Odorants/*analysis
Oryza/*chemistry
Pyrroles/*analysis
Gas Chromatography-Mass Spectrometry ; Olfactometry ; Pyrroles/chemistry ; Pyrroles/isolation & purification ; Solid Phase Microextraction
Czasopismo naukowe
Tytuł :
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
Autorzy :
Lategahn J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Hardick J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Grabe T; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Niggenaber J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Jeyakumar K; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Tumbrink HL; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Becker C; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Hodson L; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, 7602 Matieland, South Africa.
Kirschner T; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Klövekorn P; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Ketzer J; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, Medical School, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Baumann M; Lead Discovery Center GmbH, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.
Terheyden S; Lead Discovery Center GmbH, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.
Unger A; Lead Discovery Center GmbH, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.
Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Müller MP; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
van Otterlo WAL; Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, 7602 Matieland, South Africa.
Bauer S; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, Medical School, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11725-11755. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Pyrroles/*pharmacology
Receptor, ErbB-2/*antagonists & inhibitors
Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Humans ; Kinetics ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/isolation & purification ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19.
Autorzy :
Lê MP; AP-HP, Bichat Claude Bernard Hospital, Pharmacology-Toxicology Department, Paris, France .; INSERM, UMRS 1144, Université de Paris, Paris, France.
Le Hingrat Q; AP-HP, Bichat Claude Bernard Hospital, Virology Department, Paris, France.; IAME, INSERM, UMRS 1137, Université de Paris, Paris, France.
Jaquet P; AP-HP, Bichat Claude Bernard Hospital, Medical and Infectious Diseases ICU (MI2), Paris, France.
Wicky PH; AP-HP, Bichat Claude Bernard Hospital, Medical and Infectious Diseases ICU (MI2), Paris, France.
Bunel V; AP-HP, Bichat Claude Bernard Hospital, Pneumology B and Lung Transplant Department, INSERM 1152, Paris, France.
Massias L; AP-HP, Bichat Claude Bernard Hospital, Pharmacology-Toxicology Department, Paris, France.; IAME, INSERM, UMRS 1137, Université de Paris, Paris, France.
Visseaux B; AP-HP, Bichat Claude Bernard Hospital, Virology Department, Paris, France.; IAME, INSERM, UMRS 1137, Université de Paris, Paris, France.
Messika J; AP-HP, Bichat Claude Bernard Hospital, Pneumology B and Lung Transplant Department, INSERM 1152, Paris, France.
Descamps D; AP-HP, Bichat Claude Bernard Hospital, Virology Department, Paris, France.; IAME, INSERM, UMRS 1137, Université de Paris, Paris, France.
Mal H; AP-HP, Bichat Claude Bernard Hospital, Pneumology B and Lung Transplant Department, INSERM 1152, Paris, France.
Timsit JF; IAME, INSERM, UMRS 1137, Université de Paris, Paris, France.; AP-HP, Bichat Claude Bernard Hospital, Medical and Infectious Diseases ICU (MI2), Paris, France.
Peytavin G; AP-HP, Bichat Claude Bernard Hospital, Pharmacology-Toxicology Department, Paris, France.; IAME, INSERM, UMRS 1137, Université de Paris, Paris, France.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Oct 20; Vol. 64 (11). Date of Electronic Publication: 2020 Oct 20 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*administration & dosage
Betacoronavirus/*drug effects
Coronavirus Infections/*therapy
Furans/*urine
Pneumonia, Viral/*therapy
Pyrroles/*urine
Triazines/*urine
beta-Cyclodextrins/*urine
Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/metabolism ; Alanine/administration & dosage ; Alanine/adverse effects ; Alanine/chemistry ; Alanine/metabolism ; Antiviral Agents/adverse effects ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/surgery ; Coronavirus Infections/virology ; Drug Interactions ; Furans/adverse effects ; Furans/chemistry ; Humans ; Intensive Care Units ; Lung Transplantation ; Multiple Organ Failure ; Pandemics ; Pneumonia, Viral/surgery ; Pneumonia, Viral/virology ; Pyrroles/adverse effects ; Pyrroles/chemistry ; Renal Dialysis ; SARS-CoV-2 ; Transplant Recipients ; Triazines/adverse effects ; Triazines/chemistry ; beta-Cyclodextrins/adverse effects ; beta-Cyclodextrins/chemistry
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Novel pyrrolopyrimidine derivatives induce p53-independent apoptosis via the mitochondrial pathway in colon cancer cells.
Autorzy :
Kilic-Kurt Z; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey. Electronic address: .
Aka Y; Baskent University School of Medicine, Department of Immunology, Adana Dr. Turgut Noyan Medical and Research Center, Adana, Turkey.
Kutuk O; Baskent University School of Medicine, Department of Immunology, Adana Dr. Turgut Noyan Medical and Research Center, Adana, Turkey.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Oct 01; Vol. 330, pp. 109236. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Colonic Neoplasms/*drug therapy
Pyrimidines/*pharmacology
Pyrroles/*pharmacology
Tumor Suppressor Protein p53/*physiology
Caspase 3/genetics ; Caspase 9/genetics ; Cell Line, Tumor ; Colonic Neoplasms/pathology ; Gene Knockout Techniques ; HCT116 Cells ; Humans ; Mitochondria/metabolism ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Tumor Suppressor Protein p53/genetics ; bcl-2 Homologous Antagonist-Killer Protein/genetics ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Pexidartinib (TURALIO™): The First FDA-Indicated Systemic Treatment for Tenosynovial Giant Cell Tumor.
Autorzy :
Monestime S; University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, RES 435B, Fort Worth, TX, 76107, USA.
Lazaridis D; Department of Pharmacy, Memorial Regional Hospital, 3501 Johnson Street, Hollywood, FL, 33021, USA. .
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Źródło :
Drugs in R&D [Drugs R D] 2020 Sep; Vol. 20 (3), pp. 189-195.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aminopyridines/*therapeutic use
Antineoplastic Agents/*therapeutic use
Giant Cell Tumor of Tendon Sheath/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Pyrroles/*therapeutic use
Administration, Oral ; Adult ; Aminopyridines/administration & dosage ; Aminopyridines/adverse effects ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Clinical Trials as Topic ; Contraindications, Drug ; Drug Approval ; Drug Interactions ; Female ; Humans ; Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Male ; Middle Aged ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Pyrroles/administration & dosage ; Pyrroles/adverse effects ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Synthesis, in vitro safety and antioxidant activity of new pyrrole hydrazones.
Autorzy :
Tzankova D; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia 1000 Sofia, Bulgaria.
Vladimirova S; Department of Organic Synthesis and Fuels, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria.
Aluani D; Department of Pharmacology Pharmacotherapy and Toxicology Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.
Yordanov Y; Department of Pharmacology Pharmacotherapy and Toxicology Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.
Peikova L; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia 1000 Sofia, Bulgaria.
Georgieva M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia 1000 Sofia, Bulgaria.
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Źródło :
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2020 Sep 01; Vol. 70 (3), pp. 303-324.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*pharmacology
Hydrazones/*pharmacology
Pyrroles/*pharmacology
Animals ; Antioxidants/chemistry ; Antioxidants/toxicity ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/pharmacology ; Free Radical Scavengers/toxicity ; Hemolysis/drug effects ; Hep G2 Cells ; Humans ; Hydrazones/chemistry ; Hydrazones/toxicity ; Male ; Pyrroles/chemistry ; Pyrroles/toxicity ; Rats ; Rats, Wistar ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Sponge-derived Ageladine A affects the in vivo fluorescence emission spectra of microalgae.
Autorzy :
Peter C; Division of Biosciences, Department of Ecological Chemistry, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany.
Thoms S; Division of Biosciences, Department of Ecological Chemistry, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany.
Koch F; Division of Biosciences, Department of Ecological Chemistry, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany.; Department 2, University of Applied Sciences, Bremerhaven, Germany.
Sartoris FJ; Division of Biosciences, Department of Integrative Ecophysiology, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany.
Bickmeyer U; Division of Biosciences, Department of Ecological Chemistry, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany.
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Źródło :
PloS one [PLoS One] 2020 Nov 19; Vol. 15 (11), pp. e0242464. Date of Electronic Publication: 2020 Nov 19 (Print Publication: 2020).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Symbiosis*
Agelas/*chemistry
Microalgae/*drug effects
Pyrroles/*pharmacology
Animals ; Chlorophyll A/chemistry ; Fluorescence ; Micrasterias/drug effects ; Micrasterias/metabolism ; Microalgae/metabolism ; Photosynthesis/drug effects ; Photosynthesis/radiation effects ; Phycobilisomes/chemistry ; Phycobilisomes/drug effects ; Phycoerythrin/chemistry ; Pigments, Biological/chemistry ; Pyrroles/isolation & purification ; Species Specificity ; Spectrometry, Fluorescence ; Synechococcus/drug effects ; Synechococcus/metabolism ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
DNA Alkylation of the RUNX-Binding Sequence by CBI-PI Polyamide Conjugates*.
Autorzy :
Maeda R; Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University, Sakyo-ku, Kyoto, 6068306, Japan.
Ito S; Medical Research Support Center, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, 6068501, Japan.
Hashiya K; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 6068502, Japan.
Bando T; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 6068502, Japan.
Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 6068502, Japan.; Institute for Integrated Cell-Material Science (iCeMS), Kyoto University, Yoshida-ushinomiyacho Sakyo-ku, Kyoto, 6068501, Japan.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Nov 17; Vol. 26 (64), pp. 14639-14644. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Nylons*
Pyrroles*
Alkylation ; DNA/metabolism ; Imidazoles
Czasopismo naukowe
Tytuł :
Financial Implications of Avapritinib for Treatment of Unresectable Gastrointestinal Stromal Tumors in Patients With a PDGFRA Exon 18 Variant or After 3 Previous Therapies in a Hypothetical US Health Plan.
Autorzy :
Proudman D; Analysis Group Inc, Menlo Park, California.
Miller A; Analysis Group Inc, Menlo Park, California.
Nellesen D; Analysis Group Inc, Menlo Park, California.
Gomes A; Analysis Group Inc, Menlo Park, California.
Mankoski R; Blueprint Medicines Corporation, Cambridge, Massachusetts.
Norregaard C; Blueprint Medicines Corporation, Cambridge, Massachusetts.
Sullivan E; Blueprint Medicines Corporation, Cambridge, Massachusetts.
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Źródło :
JAMA network open [JAMA Netw Open] 2020 Nov 02; Vol. 3 (11), pp. e2025866. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*economics
Gastrointestinal Neoplasms/*drug therapy
Gastrointestinal Stromal Tumors/*drug therapy
Managed Care Programs/*economics
Pyrazoles/*economics
Pyrroles/*economics
Triazines/*economics
Antineoplastic Agents/therapeutic use ; Budgets ; Cost-Benefit Analysis ; Formularies as Topic ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/secondary ; Humans ; Imatinib Mesylate/economics ; Imatinib Mesylate/therapeutic use ; Medicaid ; Medicare ; Molecular Diagnostic Techniques/economics ; Phenylurea Compounds/economics ; Phenylurea Compounds/therapeutic use ; Pyrazoles/therapeutic use ; Pyridines/economics ; Pyridines/therapeutic use ; Pyrimidines/economics ; Pyrimidines/therapeutic use ; Pyrroles/therapeutic use ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Sulfonamides/economics ; Sulfonamides/therapeutic use ; Sunitinib/economics ; Sunitinib/therapeutic use ; Treatment Failure ; Triazines/therapeutic use ; United States
Czasopismo naukowe
Tytuł :
Sitagliptin and tofacitinib ameliorate adjuvant induced arthritis via modulating the cross talk between JAK/STAT and TLR-4/NF-κB signaling pathways.
Autorzy :
Ibrahim SSA; Department of Pharmacology and Therapeutics, Pharos University in Alexandria, Alexandria, Egypt. Electronic address: .
Salama MA; Department of Pharmacology, Medical Research Institute, Alexandria, Egypt.
Selima E; Department of Pharmacology, Medical Research Institute, Alexandria, Egypt.
Shehata RR; Department of Pharmacology, Medical Research Institute, Alexandria, Egypt.
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118261. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis, Experimental/*drug therapy
Piperidines/*administration & dosage
Pyrimidines/*administration & dosage
Pyrroles/*administration & dosage
Signal Transduction/*drug effects
Sitagliptin Phosphate/*administration & dosage
Toll-Like Receptor 4/*metabolism
Animals ; Anti-Inflammatory Agents ; Blood Glucose/analysis ; Drug Synergism ; Drug Therapy, Combination ; Hypoglycemic Agents ; Interleukin-6/blood ; Janus Kinases/metabolism ; Lipids/blood ; Male ; NF-kappa B/metabolism ; Piperidines/pharmacology ; Protein Kinase Inhibitors ; Pyrimidines/pharmacology ; Pyrroles/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor Cross-Talk/drug effects ; STAT Transcription Factors/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Efficacy and Safety of PF-06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor, in Patients With Moderate-to-Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate.
Autorzy :
Robinson MF; California Medical Research Associates, Northridge.
Damjanov N; University of Belgrade School of Medicine, Belgrade, Serbia.
Stamenkovic B; Institute for Treatment and Rehabilitation Niska Banja and Nis University School of Medicine, Nis, Serbia.
Radunovic G; University of Belgrade School of Medicine, Belgrade, Serbia.
Kivitz A; Altoona Center for Clinical Research, Duncansville, Pennsylvania.
Cox L; Pfizer, Inc., New York, New York.
Manukyan Z; Pfizer, Inc., New York, New York.
Banfield C; Pfizer, Inc., New York, New York.
Saunders M; Pfizer, Inc., New York, New York.
Chandra D; Pfizer, Inc., New York, New York.
Vincent MS; Pfizer, Inc., New York, New York.
Mancuso J; Pfizer, Inc., Groton, Connecticut.
Peeva E; Pfizer, Inc., New York, New York.
Beebe JS; Pfizer, Inc., New York, New York.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2020 Oct; Vol. 72 (10), pp. 1621-1631. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antirheumatic Agents/*therapeutic use
Arthritis, Rheumatoid/*drug therapy
Janus Kinase 3/*antagonists & inhibitors
Protein Kinase Inhibitors/*therapeutic use
Pyrimidines/*therapeutic use
Pyrroles/*therapeutic use
Adult ; Aged ; Antirheumatic Agents/adverse effects ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Protein Kinase Inhibitors/adverse effects ; Pyrimidines/adverse effects ; Pyrroles/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.
Autorzy :
Degorce SL; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
Tavana O; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
Banks E; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
Crafter C; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, U.K.
Gingipalli L; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
Kouvchinov D; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA, United States.
Mao Y; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, U.K.
Pachl F; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA, United States.
Solanki A; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, U.K.
Valge-Archer V; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, U.K.
Yang B; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
Edmondson SD; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Sep 24; Vol. 63 (18), pp. 10460-10473. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-1 Receptor-Associated Kinases/*metabolism
Phthalimides/*pharmacology
Proteolysis/*drug effects
Pyrroles/*pharmacology
Triazines/*pharmacology
Adaptor Proteins, Signal Transducing/metabolism ; Humans ; Ligands ; Phthalimides/chemical synthesis ; Pyrroles/chemical synthesis ; THP-1 Cells ; Triazines/chemical synthesis ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe

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