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Tytuł:
Suppression of pyrrolidine ring biosynthesis and its effects on gene expression and subsequent accumulation of anatabine in leaves of tobacco (N. tabacum L.).
Autorzy:
Kaminski KP; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Bovet L; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Hilfiker A; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Laparra H; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Schwaar J; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Sierro N; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Lang G; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
De Palo D; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Guy PA; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Laszlo C; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Goepfert S; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Ivanov NV; Philip Morris International R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. .
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Źródło:
BMC genomics [BMC Genomics] 2023 Sep 04; Vol. 24 (1), pp. 516. Date of Electronic Publication: 2023 Sep 04.
Typ publikacji:
Journal Article
MeSH Terms:
Nicotiana*/genetics
Alkaloids*
Nicotine ; Plant Leaves/genetics ; Pyrrolidines ; Gene Expression
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chemical and metabolic profiling of Codonopsis Radix extract with an integrated strategy using ultra-high-performance liquid chromatography coupled with mass spectrometry.
Autorzy:
Tang XY; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
Zeng JX; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
Wang XX; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
Xu WY; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
Zhao PC; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
Fan CL; College of Medicine, Henan Engineering Research Center of Funiu Mountain's Medicinal Resources Utilization and Molecular Medicine, Pingdingshan University, Pingdingshan, P. R. China.
Yao ZH; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
Yao XS; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
Dai Y; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, P. R. China.
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Źródło:
Journal of separation science [J Sep Sci] 2023 Jan; Vol. 46 (2), pp. e2200723. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
Drugs, Chinese Herbal*/analysis
Codonopsis*/chemistry
Codonopsis*/metabolism
Alkaloids*/chemistry
Rats ; Animals ; Rats, Sprague-Dawley ; Chromatography, High Pressure Liquid/methods ; Xenobiotics/metabolism ; Mass Spectrometry/methods ; Pyrrolidines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative.
Autorzy:
Kolaczynska KE; Division of Psychopharmacology Research, Department of Biomedicine, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
Thomann J; Division of Psychopharmacology Research, Department of Biomedicine, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
Hoener MC; Neuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.
Liechti ME; Division of Psychopharmacology Research, Department of Biomedicine, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 31; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*chemistry
Dopamine Plasma Membrane Transport Proteins/*antagonists & inhibitors
Norepinephrine Plasma Membrane Transport Proteins/*antagonists & inhibitors
Psychotropic Drugs/*chemistry
Pyrrolidines/*chemistry
Serotonin Plasma Membrane Transport Proteins/*metabolism
Alkaloids/pharmacology ; Biogenic Monoamines/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism ; HEK293 Cells ; Humans ; Norepinephrine Plasma Membrane Transport Proteins/metabolism ; Protein Binding ; Psychotropic Drugs/pharmacology ; Pyrrolidines/pharmacology ; Quantitative Structure-Activity Relationship ; Selective Serotonin Reuptake Inhibitors/chemistry ; Selective Serotonin Reuptake Inhibitors/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pyrrolidinyl Synthetic Cathinones α-PHP and 4F-α-PVP Metabolite Profiling Using Human Hepatocyte Incubations.
Autorzy:
Carlier J; Chemistry & Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.; Department of Excellence of Biomedical Sciences and Public Health, Unit of Forensic Toxicology, Section of Legal Medicine, Marche Polytechnic University, 60126 Ancona, Italy.; Department of Anatomical, Histological, Unit of Forensic Toxicology, Section of Legal Medicine, Forensic, and Orthopedic Sciences, Sapienza University of Rome, 00198 Rome, Italy.
Diao X; Chemistry & Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Giorgetti R; Department of Excellence of Biomedical Sciences and Public Health, Unit of Forensic Toxicology, Section of Legal Medicine, Marche Polytechnic University, 60126 Ancona, Italy.
Busardò FP; Department of Excellence of Biomedical Sciences and Public Health, Unit of Forensic Toxicology, Section of Legal Medicine, Marche Polytechnic University, 60126 Ancona, Italy.
Huestis MA; Chemistry & Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.; Institute of Emerging Health Professions, Thomas Jefferson University, PA 19107 Philadelphia, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 28; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Metabolomics*
Alkaloids/*metabolism
Hepatocytes/*metabolism
Pyrrolidines/*metabolism
Alkaloids/chemistry ; Humans ; Hydroxylation ; Metabolic Networks and Pathways ; Oxidation-Reduction ; Pyrrolidines/chemistry ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis of Pyrrolidine- and γ-Lactam-Containing Natural Products and Related Compounds from Pyrrole Scaffolds.
Autorzy:
Olivier WJ; School of Natural Sciences-Chemistry, University of Tasmania Hobart, Tasmania, Australia.
Smith JA; School of Natural Sciences-Chemistry, University of Tasmania Hobart, Tasmania, Australia.
Bissember AC; School of Natural Sciences-Chemistry, University of Tasmania Hobart, Tasmania, Australia.
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Źródło:
Chemical record (New York, N.Y.) [Chem Rec] 2022 Mar; Vol. 22 (3), pp. e202100277. Date of Electronic Publication: 2021 Dec 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alkaloids*
Biological Products*
Humans ; Lactams ; Pyrroles ; Pyrrolidines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of ent -Kauranic Derivatives.
Autorzy:
Pruteanu E; Institute of Chemistry (MECC), Str. Academiei, 3, MD-2028 Chișinău, Moldova.; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Gîrbu V; Institute of Chemistry (MECC), Str. Academiei, 3, MD-2028 Chișinău, Moldova.
Ungur N; Institute of Chemistry (MECC), Str. Academiei, 3, MD-2028 Chișinău, Moldova.
Persoons L; KU Leuven, Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Herestraat 49, 3000 Leuven, Belgium.
Daelemans D; KU Leuven, Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Herestraat 49, 3000 Leuven, Belgium.
Renaud P; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Kulcițki V; Institute of Chemistry (MECC), Str. Academiei, 3, MD-2028 Chișinău, Moldova.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 28; Vol. 26 (15). Date of Electronic Publication: 2021 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*chemical synthesis
Antineoplastic Agents/*chemical synthesis
Biological Products/*chemistry
Diterpenes, Kaurane/*chemical synthesis
Heterocyclic Compounds/*chemical synthesis
Alkaloids/pharmacology ; Alkylation ; Antineoplastic Agents/pharmacology ; Azides/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Diterpenes, Kaurane/pharmacology ; Free Radicals/chemistry ; Heterocyclic Compounds/pharmacology ; Humans ; Inhibitory Concentration 50 ; Iodine/chemistry ; Lactams/chemistry ; Pyrrolidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single Exposure to the Cathinones MDPV and α-PVP Alters Molecular Markers of Neuroplasticity in the Adult Mouse Brain.
Autorzy:
Caffino L; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.
Mottarlini F; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.
Bilel S; Section of Legal Medicine and LTTA Center, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Targa G; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.
Tirri M; Section of Legal Medicine and LTTA Center, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Maggi C; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.
Marti M; Section of Legal Medicine and LTTA Center, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.; Collaborative Center for the Italian National Early Warning System, Department of Anti-Drug Policies, Presidency of the Council of Ministers, 44121 Ferrara, Italy.
Fumagalli F; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 09; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*pharmacology
Frontal Lobe/*drug effects
Hippocampus/*drug effects
Neuronal Plasticity/*drug effects
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Benzodioxoles/pharmacology ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Central Nervous System Stimulants/pharmacology ; Dopamine Uptake Inhibitors/pharmacology ; Frontal Lobe/metabolism ; Gene Expression Regulation/drug effects ; Glutamic Acid/metabolism ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Pentanones/pharmacology ; Pyrrolidines/pharmacology ; gamma-Aminobutyric Acid/metabolism ; Synthetic Cathinone
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Evaluation of Cytotoxic and Mutagenic Effects of the Synthetic Cathinones Mexedrone, α-PVP and α-PHP.
Autorzy:
Lenzi M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
Cocchi V; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
Gasperini S; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
Arfè R; Section of Legal Medicine and LTTA Centre, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Marti M; Section of Legal Medicine and LTTA Centre, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.; Collaborative Center for the Italian National Early Warning System, Department of Anti-Drug Policies, Presidency of the Council of Ministers, 44121 Ferrara, Italy.
Hrelia P; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 12; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 12.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*toxicity
Methamphetamine/*analogs & derivatives
Mutagens/*toxicity
Pentanones/*toxicity
Pyrrolidines/*toxicity
Apoptosis/drug effects ; Cell Death/drug effects ; Cell Line ; Cell Survival/drug effects ; Humans ; Methamphetamine/toxicity ; Micronucleus, Germline/drug effects ; Micronucleus, Germline/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis of the Hexahydropyrrolo-[3,2-c]-quinoline Core Structure and Strategies for Further Elaboration to Martinelline, Martinellic Acid, Incargranine B, and Seneciobipyrrolidine.
Autorzy:
Haarr MB; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, NO-4036 Stavanger, Norway.
Sydnes MO; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, NO-4036 Stavanger, Norway.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jan 11; Vol. 26 (2). Date of Electronic Publication: 2021 Jan 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alkaloids/*chemical synthesis
Pyrroles/*chemical synthesis
Pyrrolidines/*chemical synthesis
Quinolines/*chemical synthesis
Bignoniaceae/chemistry ; Biological Products/chemical synthesis ; Chemistry Techniques, Synthetic/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Flakka: New Dangerous Synthetic Cathinone on the Drug Scene.
Autorzy:
Patocka J; Department of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia, 37005 Ceske Budejovice, Czech Republic.; Biomedical Research Centre, University Hospital, 50003 Hradec Kralove, Czech Republic.
Zhao B; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Wu W; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.
Klimova B; Department of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
Valis M; Department of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.
Kuca K; Biomedical Research Centre, University Hospital, 50003 Hradec Kralove, Czech Republic.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 31; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alkaloids/*poisoning
Central Nervous System Stimulants/*poisoning
Illicit Drugs/*poisoning
Pentanones/*poisoning
Psychotropic Drugs/*poisoning
Pyrrolidines/*poisoning
Substance-Related Disorders/*etiology
Humans ; Structure-Activity Relationship ; Substance-Related Disorders/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthetic Cathinones Induce Cell Death in Dopaminergic SH-SY5Y Cells via Stimulating Mitochondrial Dysfunction.
Autorzy:
Leong HS; Centre for Forensic Science, School of Mathematical and Physical Sciences, University of Technology Sydney, Ultimo NSW 2007, Australia.; Discipline of Pathology, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown NSW 2006, Australia.
Philp M; Centre for Forensic Science, School of Mathematical and Physical Sciences, University of Technology Sydney, Ultimo NSW 2007, Australia.
Simone M; Discipline of Pathology, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown NSW 2006, Australia.
Witting PK; Discipline of Pathology, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown NSW 2006, Australia.
Fu S; Centre for Forensic Science, School of Mathematical and Physical Sciences, University of Technology Sydney, Ultimo NSW 2007, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 18; Vol. 21 (4). Date of Electronic Publication: 2020 Feb 18.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*pharmacology
Dopaminergic Neurons/*cytology
Mitochondria/*metabolism
Adenosine Triphosphate/metabolism ; Alkaloids/chemistry ; Amphetamines/chemistry ; Amphetamines/pharmacology ; Benzodioxoles/chemistry ; Benzodioxoles/pharmacology ; Calcium/metabolism ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Energy Metabolism ; Homeostasis/drug effects ; Humans ; Mitochondria/drug effects ; Neurotoxins/toxicity ; Oxidative Stress/drug effects ; Oxygen Consumption/drug effects ; Pyrrolidines/chemistry ; Pyrrolidines/pharmacology ; Reactive Oxygen Species/metabolism ; Synthetic Cathinone
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Cathinones MDPV and α-PVP Elicit Different Behavioral and Molecular Effects Following Acute Exposure.
Autorzy:
Giannotti G; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.
Canazza I; Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, via Fossato di Mortara 17-19, 44121, Ferrara, Italy.; Institute of Public Health, Section of Legal Medicine, Catholic University of Rome, Rome, Italy.
Caffino L; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.
Bilel S; Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, via Fossato di Mortara 17-19, 44121, Ferrara, Italy.
Ossato A; Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, via Fossato di Mortara 17-19, 44121, Ferrara, Italy.; Institute of Public Health, Section of Legal Medicine, Catholic University of Rome, Rome, Italy.
Fumagalli F; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.
Marti M; Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, via Fossato di Mortara 17-19, 44121, Ferrara, Italy. .; Center for Neuroscience and Istituto Nazionale di Neuroscienze, Ferrara, Italy. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2017 Nov; Vol. 32 (4), pp. 594-602. Date of Electronic Publication: 2017 Jun 23.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*pharmacology
Dopamine Plasma Membrane Transport Proteins/*drug effects
Motor Activity/*drug effects
Pentanones/*pharmacology
Pyrrolidines/*pharmacology
Alkaloids/administration & dosage ; Animals ; Central Nervous System Stimulants/pharmacology ; Designer Drugs ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Dose-Response Relationship, Drug ; Male ; Mice ; Pentanones/administration & dosage ; Pyrrolidines/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (α-PVP) in rhesus monkeys.
Autorzy:
Collins GT; Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX, 78229, USA. .; Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center, San Antonio, TX, 78229, USA. .; South Texas Veterans Health Care System, San Antonio, TX, 78229, USA. .
Sulima A; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20850, USA.
Rice KC; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20850, USA.
France CP; Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX, 78229, USA.; Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center, San Antonio, TX, 78229, USA.; Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, 78229, USA.
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2019 Dec; Vol. 236 (12), pp. 3677-3685. Date of Electronic Publication: 2019 Jul 26.
Typ publikacji:
Journal Article
MeSH Terms:
Reinforcement, Psychology*
Alkaloids/*administration & dosage
Benzodioxoles/*administration & dosage
Designer Drugs/*administration & dosage
Pentanones/*administration & dosage
Pyrrolidines/*administration & dosage
Animals ; Cocaine/administration & dosage ; Dose-Response Relationship, Drug ; Macaca mulatta ; Male ; Methamphetamine/administration & dosage ; Psychotropic Drugs/administration & dosage ; Rats, Sprague-Dawley ; Self Administration ; Synthetic Cathinone
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vitro inhibitory and cytotoxic activity of MFM 501, a novel codonopsinine derivative, against Methicillin-Resistant Staphylococcus aureus clinical isolates.
Autorzy:
Johari SA; Antimicrobial Laboratory, Anti-Infective Branch, Bioactivity Programme, Natural Products Division, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Malaysia ; Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia.
Mohtar M; Antimicrobial Laboratory, Anti-Infective Branch, Bioactivity Programme, Natural Products Division, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Malaysia.
Mohammad SA; Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia.
Sahdan R; Biotherapeutic Branch, Bioactivity Programme, Natural Products Division, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Malaysia.
Shaameri Z; Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia.
Hamzah AS; Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia.
Mohammat MF; Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia.
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Źródło:
BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 823829. Date of Electronic Publication: 2015 Feb 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alkaloids/*administration & dosage
Anti-Bacterial Agents/*administration & dosage
Methicillin-Resistant Staphylococcus aureus/*drug effects
Methicillin-Resistant Staphylococcus aureus/*physiology
Pyrrolidines/*administration & dosage
Alkaloids/chemistry ; Anti-Bacterial Agents/chemistry ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Methicillin-Resistant Staphylococcus aureus/cytology ; Microbial Sensitivity Tests ; Pyrrolidines/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthetic cathinones in Southern Germany - characteristics of users, substance-patterns, co-ingestions, and complications.
Autorzy:
Romanek K; a Department of Clinical Toxicology , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
Stenzel J; a Department of Clinical Toxicology , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
Schmoll S; a Department of Clinical Toxicology , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
Schrettl V; a Department of Clinical Toxicology , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
Geith S; a Department of Clinical Toxicology , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
Eyer F; a Department of Clinical Toxicology , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
Rabe C; a Department of Clinical Toxicology , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
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Źródło:
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2017 Jul; Vol. 55 (6), pp. 573-578. Date of Electronic Publication: 2017 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*adverse effects
Hospitalization/*statistics & numerical data
Illicit Drugs/*adverse effects
Substance-Related Disorders/*epidemiology
Academic Medical Centers ; Adolescent ; Adult ; Alkaloids/administration & dosage ; Benzodioxoles/administration & dosage ; Female ; Germany/epidemiology ; Humans ; Male ; Methamphetamine/administration & dosage ; Methamphetamine/analogs & derivatives ; Middle Aged ; Pyrrolidines/administration & dosage ; Retrospective Studies ; Young Adult ; Synthetic Cathinone
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG).
Autorzy:
Hicks C; Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA.; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Gregg RA; Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA.; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Nayak SU; Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA.; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Cannella LA; Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA.
Schena GJ; Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA.; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Tallarida CS; Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA.; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Reitz AB; Fox Chase Chemical Diversity Center, Doylestown, PA, USA.
Smith GR; Fox Chase Chemical Diversity Center, Doylestown, PA, USA.
Rawls SM; Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA. .; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2017 Jun; Vol. 234 (11), pp. 1671-1681. Date of Electronic Publication: 2017 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Reward*
Alkaloids/*administration & dosage
Benzodioxoles/*administration & dosage
Dipeptides/*pharmacology
Glutamate Carboxypeptidase II/*biosynthesis
Organophosphorus Compounds/*pharmacology
Pyrrolidines/*administration & dosage
Amino Acids/pharmacology ; Animals ; Conditioning, Psychological/drug effects ; Conditioning, Psychological/physiology ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamate Carboxypeptidase II/antagonists & inhibitors ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/antagonists & inhibitors ; Receptors, Metabotropic Glutamate/physiology ; Xanthenes/pharmacology ; Synthetic Cathinone
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Formal Total Synthesis of (±)-Strictamine by [2,3]-Sigmatropic Stevens Rearrangements.
Autorzy:
Eckermann R; Faculty of Chemistry, University of Konstanz, Universitätsstr. 10, 78457, Konstanz, Germany.; Current address: Department of Medicinal Chemistry, University of Minnesota, 2231 Sixth Street SE, Minneapolis, Minnesota, 55455, USA.
Breunig M; Faculty of Chemistry, University of Konstanz, Universitätsstr. 10, 78457, Konstanz, Germany.
Gaich T; Faculty of Chemistry, University of Konstanz, Universitätsstr. 10, 78457, Konstanz, Germany.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Mar 17; Vol. 23 (16), pp. 3938-3949. Date of Electronic Publication: 2017 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*chemical synthesis
Anti-Inflammatory Agents/*chemical synthesis
Alkaloids/chemistry ; Anti-Inflammatory Agents/chemistry ; Apocynaceae/chemistry ; Azabicyclo Compounds/chemical synthesis ; Azabicyclo Compounds/chemistry ; Azo Compounds/chemical synthesis ; Azo Compounds/chemistry ; Cycloaddition Reaction ; Models, Molecular ; Oxidation-Reduction ; Pyrrolidines/chemical synthesis ; Pyrrolidines/chemistry ; Stereoisomerism ; Thiosemicarbazones/chemical synthesis ; Thiosemicarbazones/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chemical constituents of Arisaema franchetianum tubers.
Autorzy:
Su Y; Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Xu JJ
Bi JL
Wang YH
Hu GW
Yang J
Yin GF
Long CL
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Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2013; Vol. 15 (1), pp. 71-7. Date of Electronic Publication: 2012 Oct 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alkaloids/*isolation & purification
Antineoplastic Agents, Phytogenic/*isolation & purification
Antiviral Agents/*isolation & purification
Arisaema/*chemistry
Pyrrolidines/*isolation & purification
Alkaloids/chemistry ; Alkaloids/pharmacology ; Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Drug Screening Assays, Antitumor ; Female ; Glucosides/chemistry ; Glucosides/isolation & purification ; Glycosides/chemistry ; Glycosides/isolation & purification ; Glycosides/pharmacology ; Humans ; Inhibitory Concentration 50 ; K562 Cells ; Lignans/chemistry ; Lignans/isolation & purification ; MCF-7 Cells ; Molecular Structure ; Oleanolic Acid/analogs & derivatives ; Oleanolic Acid/chemistry ; Oleanolic Acid/isolation & purification ; Plant Tubers/chemistry ; Porcine respiratory and reproductive syndrome virus/drug effects ; Pyrrolidines/chemistry ; Pyrrolidines/pharmacology ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica.
Autorzy:
Liu XC; Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China. .
Lai D; Department of Plant Pathology, China Agricultural University, Haidian District, Beijing 100193, China. .
Liu QZ; Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China. .
Zhou L; Department of Plant Pathology, China Agricultural University, Haidian District, Beijing 100193, China. .
Liu Q; State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center of Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. .
Liu ZL; Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2016 Dec 02; Vol. 21 (12). Date of Electronic Publication: 2016 Dec 02.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*pharmacology
Antinematodal Agents/*pharmacology
Insecticides/*pharmacology
Plant Bark/*chemistry
Pyrrolidines/*pharmacology
Pyrrolidinones/*pharmacology
Rutaceae/*chemistry
Aedes/drug effects ; Animals ; Anopheles/drug effects ; Culex/drug effects ; Larva/drug effects ; Nematoda/drug effects ; Plant Extracts/pharmacology ; Plant Roots/chemistry ; Pyrrolidinones/isolation & purification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 196

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