Temat: "Pyrrolidinones" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2α-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells.
Autorzy :: Zhang F; School of Public Health, MOE Key Laboratory for Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China.
Ni Z; School of Public Health, MOE Key Laboratory for Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China.
Zhao S; School of Public Health, MOE Key Laboratory for Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China.
Wang Y; School of Public Health, MOE Key Laboratory for Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China.
Chang X; School of Public Health, MOE Key Laboratory for Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China.
Zhou Z; School of Public Health, MOE Key Laboratory for Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China.; Pokaż więcej
Źródło :: International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Apr 11; Vol. 19 (8). Date of Electronic Publication: 2022 Apr 11.
Typ publikacji :: Journal Article
MeSH Terms :: Endoplasmic Reticulum Stress*/drug effects
Eukaryotic Initiation Factor-2*/metabolism
Eukaryotic Initiation Factor-2*/pharmacology
Pyrrolidinones*/pharmacology
Pyrrolidinones*/toxicity
Activating Transcription Factor 6/metabolism ; Activating Transcription Factor 6/pharmacology ; Animals ; Apoptosis ; Male ; Mice ; Sertoli Cells/metabolism ; Signal Transduction ; bcl-2-Associated X Protein
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum .
Autorzy :: Xu X; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
Tan Y; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China.
Gao C; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
Liu K; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
Tang Z; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
Lu C; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
Li H; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
Zhang X; College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China.
Liu Y; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.; Pokaż więcej
Źródło :: Marine drugs [Mar Drugs] 2022 Apr 06; Vol. 20 (4). Date of Electronic Publication: 2022 Apr 06.
Typ publikacji :: Journal Article
MeSH Terms :: Hypocreales*
Pyrrolidinones*/chemistry
Pyrrolidinones*/pharmacology
Animals ; Mice ; Molecular Structure ; RAW 264.7 Cells
SCR Organism :: Lecanicillium fusisporum
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Regioselective Radical-Relay Sulfonylation/Cyclization Protocol to Sulfonylated Pyrrolidones under Transition-Metal-Free Conditions.
Autorzy :: Liu F; College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.
Huang J; College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.; Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou, Zhejiang 318000, China.
Wu X; Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou, Zhejiang 318000, China.
Du F; School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
Zeng L; School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
Wu J; Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou, Zhejiang 318000, China.
Chen Z; College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.; School of Medicine, Zhejiang University City College, Hangzhou 310015, China.; Pokaż więcej
Źródło :: The Journal of organic chemistry [J Org Chem] 2022 May 06; Vol. 87 (9), pp. 6137-6145. Date of Electronic Publication: 2022 Apr 19.
Typ publikacji :: Journal Article
MeSH Terms :: Pyrrolidinones*
Transition Elements*
Cyclization
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Borneol-based antisolvent-induced in situ forming matrix for crevicular pocket delivery of vancomycin hydrochloride.
Autorzy :: Lertsuphotvanit N; Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address: .
Santimaleeworagun W; Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Narakornwit W; Department of Pharmacognosy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Chuenbarn T; Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Mahadlek J; Pharmaceutical Intellectual Center 'Prachote Plengwittaya', Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand; Natural Bioactive and Material for Health Promotion and Drug Delivery System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Chantadee T; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Phaechamud T; Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand; Natural Bioactive and Material for Health Promotion and Drug Delivery System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address: .; Pokaż więcej
Źródło :: International journal of pharmaceutics [Int J Pharm] 2022 Apr 05; Vol. 617, pp. 121603. Date of Electronic Publication: 2022 Feb 19.
Typ publikacji :: Journal Article
MeSH Terms :: Pyrrolidinones*/chemistry
Vancomycin*
Animals ; Camphanes ; Drug Liberation ; Solubility ; Swine
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Evaluation of Chiral Liquid Chromatographic Method for Separation and Quantification of Isomers of Brivaracetam.
Autorzy :: Choppari T; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.
Gunnam S; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.
Chennuru LN; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.
Cherla PM; Department of Chemistry, University college of science, Osmania University campus, Hyderabad-500007, Telangana, India.
Talluri MVNK; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.; Pokaż więcej
Źródło :: Journal of chromatographic science [J Chromatogr Sci] 2022 Mar 23; Vol. 60 (3), pp. 250-259.
Typ publikacji :: Journal Article
MeSH Terms :: Pyrrolidinones*
Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Isomerism ; Stereoisomerism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin.
Autorzy :: Yang S; National Institute of Biological Sciences, Beijing, 102206, China.
Chen C; National Institute of Biological Sciences, Beijing, 102206, China.
Chen J; National Institute of Biological Sciences, Beijing, 102206, China.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China.
Li C; National Institute of Biological Sciences, Beijing, 102206, China.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China.; Pokaż więcej
Źródło :: Journal of the American Chemical Society [J Am Chem Soc] 2021 Dec 22; Vol. 143 (50), pp. 21258-21263. Date of Electronic Publication: 2021 Dec 08.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Anti-Bacterial Agents/*chemical synthesis
Glucosides/*chemical synthesis
Pyrroles/*chemical synthesis
Pyrrolidinones/*chemical synthesis
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Crystallography, X-Ray ; Drug Resistance, Bacterial/drug effects ; Glucosides/chemistry ; Glucosides/pharmacology ; Gram-Positive Bacteria/drug effects ; Molecular Conformation ; Pyrroles/chemistry ; Pyrroles/pharmacology ; Pyrrolidinones/chemistry ; Pyrrolidinones/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Anti-Pathogenic Properties of the Combination of a T3SS Inhibitory Halogenated Pyrrolidone with C-30 Furanone.
Autorzy :: Aburto-Rodríguez NA; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Muñoz-Cázares N; Laboratorio de Fitoquímica, Posgrado de Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico.
Castro-Torres VA; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
González-Pedrajo B; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico.
Díaz-Guerrero M; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico.
García-Contreras R; Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Quezada H; Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de Mexico 06720, Mexico.
Castillo-Juárez I; Laboratorio de Fitoquímica, Posgrado de Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico.
Martínez-Vázquez M; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.; Pokaż więcej
Źródło :: Molecules (Basel, Switzerland) [Molecules] 2021 Dec 16; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 16.
Typ publikacji :: Journal Article
MeSH Terms :: Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Furans*/chemistry
Furans*/pharmacology
Hydrocarbons, Halogenated*/chemistry
Hydrocarbons, Halogenated*/pharmacology
Pseudomonas Infections*/drug therapy
Pseudomonas Infections*/metabolism
Pseudomonas aeruginosa*/growth & development
Pseudomonas aeruginosa*/pathogenicity
Pyrrolidinones*/chemistry
Pyrrolidinones*/pharmacology
Type III Secretion Systems/*antagonists & inhibitors
Animals ; Humans ; Mice ; Necrosis ; Quorum Sensing/drug effects ; Type III Secretion Systems/metabolism ; Virulence Factors/metabolism
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 8 8.

Tytuł :: Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists.
Autorzy :: Maciuszek M; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK; The William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK. Electronic address: .
Ortega-Gomez A; Institute for Cardiovascular Prevention (IPEK), LMU Munich Hospital, Munich, Germany.
Maas SL; Institute for Cardiovascular Prevention (IPEK), LMU Munich Hospital, Munich, Germany.
Garrido-Mesa J; The William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.
Ferraro B; Institute for Cardiovascular Prevention (IPEK), LMU Munich Hospital, Munich, Germany.
Perretti M; The William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.
Merritt A; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK.
Nicolaes GAF; CARIM - School for Cardiovascular Sciences Department of Biochemistry, Maastricht University, Maastricht, Netherlands.
Soehnlein O; Institute for Cardiovascular Prevention (IPEK), LMU Munich Hospital, Munich, Germany; Department of Physiology and Pharmacology (FyFa), Karolinska Institute, Stockholm, Sweden; Institute for Experimental Pathology (ExPat), Centre for Molecular Biology of Inflammation, University of Münster, Münster, Germany.
Chapman TM; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK.; Pokaż więcej
Źródło :: European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 15; Vol. 226, pp. 113805. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :: Journal Article
MeSH Terms :: Drug Design*
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Pyrrolidinones/*pharmacology
Receptors, Formyl Peptide/*agonists
Receptors, Lipoxin/*agonists
Small Molecule Libraries/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Pyrrolidinones/chemical synthesis ; Pyrrolidinones/chemistry ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Synthesis and preliminary biological evaluation of antibacterial and antifungal 5-arylidene tetramic acid-cadmium(II) complexes.
Autorzy :: Matiadis D; Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece.
Stefanou V; Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece.
Tsironis D; Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece.
Panagiotopoulou A; Institute of Biosciences and Applications, National Center for Scientific Research 'Demokritos', Ag. Paraskevi, Attiki, Greece.
Igglessi-Markopoulou O; Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece.
Markopoulos J; Department of Chemistry, Laboratory of Inorganic Chemistry, University of Athens, Panepistimiopolis, Athens, Greece.; Pokaż więcej
Źródło :: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Dec; Vol. 354 (12), pp. e2100305. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :: Journal Article
MeSH Terms :: Anti-Bacterial Agents/*pharmacology
Antifungal Agents/*pharmacology
Pyrrolidinones/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Bacteria/drug effects ; Cadmium/chemistry ; Fungi/drug effects ; Hemolysis/drug effects ; Humans ; Microbial Sensitivity Tests ; Pyrrolidinones/chemical synthesis ; Pyrrolidinones/chemistry ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors.
Autorzy :: Kummar S; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Srivastava AK; Clinical Pharmacodynamics Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
Navas T; Clinical Pharmacodynamics Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.; Pfizer Inc, Groton, CT, 06340, USA.
Cecchi F; Urologic Oncology Branch, NCI, Bethesda, NIH, 20892, USA.; AstraZeneca, Inc, Gaithersburg, MD, 20878, USA.
Lee YH; Urologic Oncology Branch, NCI, Bethesda, NIH, 20892, USA.; Altimmune, Inc, Gaithersburg, MD, 20878, USA.
Bottaro DP; Urologic Oncology Branch, NCI, Bethesda, NIH, 20892, USA.
Park SR; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.; Department of Oncology, University of Ulsan College of Medicine, Seoul, 138-736, South Korea.
Do KT; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.; Moderna Therapeutics, Inc, Cambridge, MA, 02139, USA.
Jeong W; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.; Millennium Physicians, Tomball, TX, 77375, USA.
Johnson BC; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.
Voth AR; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.
Rubinstein L; Biostatistics Branch, National Cancer Institute, Bethesda, MD, 20892, USA.
Wright JJ; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.
Parchment RE; Clinical Pharmacodynamics Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
Doroshow JH; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA.; Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.
Chen AP; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, 20892, USA. .; Pokaż więcej
Źródło :: Investigational new drugs [Invest New Drugs] 2021 Dec; Vol. 39 (6), pp. 1577-1586. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Angiogenesis Inhibitors/*therapeutic use
Indazoles/*therapeutic use
Neoplasms/*drug therapy
Pyrimidines/*therapeutic use
Pyrrolidinones/*therapeutic use
Quinolines/*therapeutic use
Sulfonamides/*therapeutic use
Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/adverse effects ; Angiogenesis Inhibitors/pharmacology ; Antineoplastic Combined Chemotherapy Protocols ; Area Under Curve ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Hepatocyte Growth Factor/metabolism ; Humans ; Indazoles/administration & dosage ; Indazoles/adverse effects ; Indazoles/pharmacokinetics ; Maximum Tolerated Dose ; Middle Aged ; Neoplasms/pathology ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Pyrimidines/pharmacokinetics ; Pyrrolidinones/administration & dosage ; Pyrrolidinones/adverse effects ; Pyrrolidinones/pharmacokinetics ; Quinolines/administration & dosage ; Quinolines/adverse effects ; Quinolines/pharmacokinetics ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Sulfonamides/pharmacokinetics ; Vascular Endothelial Growth Factor A/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Retro -Aza-Piancatelli Rearrangement Triggered Cascade Reaction of Methyl Furylacrylates with Anilines to Access Cyclopenta[ b ]pyrrolidinones.
Autorzy :: Xu L; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.
Li H; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.
Xing L; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.
Yang Q; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.
Tang Y; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.
Cai Y; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.; Pokaż więcej
Źródło :: The Journal of organic chemistry [J Org Chem] 2022 Jan 07; Vol. 87 (1), pp. 855-865. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Aniline Compounds*
Pyrrolidinones*
Lactams ; Stereoisomerism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Clinical predictors of response to adjunctive brivaracetam: Insights from real-world data.
Autorzy :: Lattanzi S; Department of Experimental and Clinical Medicine, Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
Chiesa V; Child Neuropsychiatry Unit, Epilepsy Center, AAST Santi Paolo Carlo, Milan, Italy.
Ferlazzo E; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
La Neve A; Department of Basic Medical Sciences, Neurosciences, and Sense Organs, University Hospital of Bari 'A. Moro,', Bari, Italy.
Pignatta P; Neurology and Epilepsy Unit, Humanitas Gradenigo Hospital, Turin, Italy.
Di Bonaventura C; Department of Human Neurosciences, Umberto I Polyclinic, Sapienza University of Rome, Rome, Italy.; Pokaż więcej
Corporate Authors :: BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST) Group
Źródło :: Epilepsia [Epilepsia] 2022 Jan; Vol. 63 (1), pp. 252-253. Date of Electronic Publication: 2021 Nov 14.
Typ publikacji :: Letter; Comment
MeSH Terms :: Anticonvulsants*/therapeutic use
Pyrrolidinones*/therapeutic use
: Opinia redakcyjna

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: N-ethyl-2-pyrrolidinone substitution enhances binding affinity between tea flavoalkaloids and human serum albumin: Greatly influenced by esterization.
Autorzy :: Liu SY; Natural Products Laboratory, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, People's Republic of China. Electronic address: .
Zhang YY; Natural Products Laboratory, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, People's Republic of China. Electronic address: .
Chu GX; Natural Products Laboratory, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, People's Republic of China. Electronic address: .
Bao GH; Natural Products Laboratory, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, People's Republic of China. Electronic address: .; Pokaż więcej
Źródło :: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Dec 05; Vol. 262, pp. 120097. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :: Journal Article
MeSH Terms :: Pyrrolidinones*
Serum Albumin, Human*
Catechin/*chemistry
Tea/*chemistry
Alkaloids/chemistry ; Binding Sites ; Circular Dichroism ; Flavanones/chemistry ; Humans ; Molecular Docking Simulation ; Protein Binding ; Spectrometry, Fluorescence ; Thermodynamics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat.
Autorzy :: Eastman CL; Department of Neurological Surgery, University of Washington, Seattle, Washington (C.L.E., J.S.F., R.D.); and Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland (P.K.) .
Fender JS; Department of Neurological Surgery, University of Washington, Seattle, Washington (C.L.E., J.S.F., R.D.); and Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland (P.K.).
Klein P; Department of Neurological Surgery, University of Washington, Seattle, Washington (C.L.E., J.S.F., R.D.); and Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland (P.K.).
D'Ambrosio R; Department of Neurological Surgery, University of Washington, Seattle, Washington (C.L.E., J.S.F., R.D.); and Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland (P.K.).; Pokaż więcej
Źródło :: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Dec; Vol. 379 (3), pp. 310-323. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Anticonvulsants/*administration & dosage
Brain Injuries/*drug therapy
Epilepsy, Post-Traumatic/*drug therapy
Pyrrolidinones/*administration & dosage
Animals ; Anticonvulsants/blood ; Brain Injuries/blood ; Brain Injuries/physiopathology ; Drug Administration Schedule ; Electrocorticography/methods ; Epilepsy, Post-Traumatic/blood ; Epilepsy, Post-Traumatic/physiopathology ; Male ; Pilot Projects ; Pyrrolidinones/blood ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: P.158: Layer by Layer Coating With Poly(N-vinylpyrrolidone) and Tannic Acid (PVPON/TA) Preserves Human and Mouse Islets In Vitro and In Vivo Functional Potency.
Autorzy :: Polishevska K; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Kelly S; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Kuppan P; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Seeberger K; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Aggarwal S; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Paramor J; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Korbutt GS; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Pepper AR; Alberta Diabetes Institute, Edmonton, AB, Canada.; Department of Surgery, University of Alberta, Edmonton, AB, Canada.; Pokaż więcej
Źródło :: Transplantation [Transplantation] 2021 Dec 01; Vol. 105 (12 Suppl 2), pp. S66.
Typ publikacji :: Journal Article
MeSH Terms :: Pyrrolidinones*
Tannins*/pharmacology
Animals ; Humans ; Mice
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST).
Autorzy :: Lattanzi S; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Via Conca 71, 60020, Ancona, Italy. .
Canafoglia L; Department of Epileptology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Canevini MP; Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, Italy.; Department of Health Sciences, Università degli Studi, Milan, Italy.
Casciato S; IRCCS Neuromed, Pozzilli, Italy.
Chiesa V; Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, Italy.
Dainese F; Epilepsy Centre, Neurology Unit, Venice, Italy.
De Maria G; Clinical Neurophysiology Unit, Epilepsy Center, Spedali Civili, Brescia, Italy.
Didato G; Epilepsy Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
Falcicchio G; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University Hospital of Bari 'A. Moro', Bari, Italy.
Fanella M; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Ferlazzo E; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.
Fisco G; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Gangitano M; Department of Biomedicine, Neuroscience, and advanced Diagnostic (BIND), University of Palermo, Palermo, Italy.
Giallonardo AT; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Giorgi FS; Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.; Neurology Unit, Pisa University Hospital, Pisa, Italy.
La Neve A; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University Hospital of Bari 'A. Moro', Bari, Italy.
Mecarelli O; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Montalenti E; Epilepsy Center, AOU Città della Salute e della Scienza di Torino, Turin, Italy.
Piazza F; Department of Neurosciences, Rita Levi Montalcini, University of Turin, Turin, Italy.
Pulitano P; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Quarato PP; IRCCS Neuromed, Pozzilli, Italy.
Ranzato F; Epilepsy Center, UOC Neurology, AULSS, 8 Vicenza, Vicenza, Italy.
Rosati E; Department Neurology 2, Careggi University Hospital, Florence, Italy.
Tassi L; C. Munari' Epilepsy Surgery Centre, Niguarda Hospital, Milan, Italy.
Di Bonaventura C; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.; Pokaż więcej
Corporate Authors :: BRIVAFIRST Group Membership
Źródło :: CNS drugs [CNS Drugs] 2021 Dec; Vol. 35 (12), pp. 1289-1301. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :: Anticonvulsants/*therapeutic use
Drug Resistant Epilepsy/*drug therapy
Epilepsies, Partial/*drug therapy
Pyrrolidinones/*therapeutic use
Adult ; Anticonvulsants/administration & dosage ; Chemotherapy, Adjuvant ; Female ; Humans ; Italy ; Levetiracetam/administration & dosage ; Levetiracetam/therapeutic use ; Male ; Middle Aged ; Pyrrolidinones/administration & dosage ; Retrospective Studies ; Treatment Outcome
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Autorzy :: Boras B; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Jones RM; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA. .
Anson BJ; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Arenson D; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Aschenbrenner L; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Bakowski MA; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Binder J; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Chen E; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Eng H; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Hammond H; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Hammond J; Worldwide Research and Development, Pfizer Inc., Collegeville, PA, 19426, USA.
Haupt RE; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Hoffman R; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Kadar EP; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Kania R; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA.
Kimoto E; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Kirkpatrick MG; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Lanyon L; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Lendy EK; Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.
Lillis JR; Worldwide Research and Development, Pfizer Inc, Sandwich, CT13 9ND, UK.
Logue J; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Luthra SA; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Ma C; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Mason SW; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
McGrath ME; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Noell S; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Obach RS; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
O' Brien MN; Worldwide Research and Development, Pfizer Inc, Lake Forest, IL, 60045, USA.
O'Connor R; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Ogilvie K; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Owen D; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Pettersson M; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Reese MR; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; UC San Diego Division of Infectious Diseases and Global Public Health, UC San Diego School of Medicine, La Jolla, CA, 92093, USA.
Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rossulek MI; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Sathish JG; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
Shirai N; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Steppan C; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.
Ticehurst M; Worldwide Research and Development, Pfizer Inc, Sandwich, CT13 9ND, UK.
Updyke LW; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.
Weston S; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Zhu Y; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wang J; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Chatterjee AK; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA.
Mesecar AD; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.
Frieman MB; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Anderson AS; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA.
Allerton C; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2021 Oct 18; Vol. 12 (1), pp. 6055. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :: COVID-19/*drug therapy
Coronavirus 3C Proteases/*antagonists & inhibitors
Coronavirus Protease Inhibitors/*administration & dosage
Indoles/*administration & dosage
Leucine/*administration & dosage
Pyrrolidinones/*administration & dosage
Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacokinetics ; Alanine/administration & dosage ; Alanine/adverse effects ; Alanine/analogs & derivatives ; Alanine/pharmacokinetics ; Animals ; COVID-19/virology ; Chlorocebus aethiops ; Coronavirus 229E, Human/drug effects ; Coronavirus 229E, Human/enzymology ; Coronavirus Protease Inhibitors/adverse effects ; Coronavirus Protease Inhibitors/pharmacokinetics ; Disease Models, Animal ; Drug Design ; Drug Synergism ; Drug Therapy, Combination ; HeLa Cells ; Humans ; Indoles/adverse effects ; Indoles/pharmacokinetics ; Infusions, Intravenous ; Leucine/adverse effects ; Leucine/pharmacokinetics ; Mice ; Pyrrolidinones/adverse effects ; Pyrrolidinones/pharmacokinetics ; SARS Virus/drug effects ; SARS Virus/enzymology ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Vero Cells
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Effect of N-Vinyl-2-Pyrrolidone (NVP), a Bromodomain-Binding Small Chemical, on Osteoblast and Osteoclast Differentiation and Its Potential Application for Bone Regeneration.
Autorzy :: Klemmer VA; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Khera N; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Siegenthaler BM; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Bhattacharya I; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Weber FE; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.; Center for Applied Biotechnology and Molecular Medicine, University of Zurich, 8057 Zurich, Switzerland.
Ghayor C; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 13; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :: Journal Article
MeSH Terms :: Bone Regeneration/*drug effects
Cell Differentiation/*drug effects
Pyrrolidinones/*pharmacology
Animals ; Bone Diseases/drug therapy ; Bone Diseases/pathology ; Bone Morphogenetic Protein 2/agonists ; Bone Morphogenetic Protein 2/metabolism ; Bone and Bones/pathology ; Cell Survival/drug effects ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/metabolism ; Disease Models, Animal ; Mice ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteoclasts/cytology ; Osteoclasts/metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Pyrrolidinones/chemistry ; Pyrrolidinones/therapeutic use ; RANK Ligand/pharmacology ; Rabbits ; Smad1 Protein/metabolism
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 19 19.

Tytuł :: Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors.
Autorzy :: Si D; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Luo H; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhang X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yang K; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Wen H; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Li W; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
Liu J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic chemistry [Bioorg Chem] 2021 Oct; Vol. 115, pp. 105268. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Drug Design*
Antineoplastic Agents/*pharmacology
Proto-Oncogene Proteins c-mdm2/*antagonists & inhibitors
Pyrrolidinones/*pharmacology
Tumor Suppressor Protein p53/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Proto-Oncogene Proteins c-mdm2/metabolism ; Pyrrolidinones/chemical synthesis ; Pyrrolidinones/chemistry ; Structure-Activity Relationship ; Tumor Suppressor Protein p53/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 .
Autorzy :: Spearing PK; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Cho HP; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Luscombe VB; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Blobaum AL; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Boutaud O; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Engers DW; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Rodriguez AL; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Niswender CM; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Jeffrey Conn P; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
Lindsley CW; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, United States; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, United States.
Bender AM; Warren Center for Neuroscience Drug Discovery, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Sep 01; Vol. 47, pp. 128193. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Drug Discovery*
Pyrrolidinones/*pharmacology
Receptor, Muscarinic M1/*agonists
Allosteric Regulation/drug effects ; Animals ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Pyrrolidinones/chemical synthesis ; Pyrrolidinones/chemistry ; Rats ; Structure-Activity Relationship
: Czasopismo naukowe

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