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Title:
Mutagenetic analysis of the biosynthetic pathway of tetramate bripiodionen bearing 3-(2H-pyran-2-ylidene)pyrrolidine-2,4-dione skeleton.
Authors:
Zang H; Research Center for Marine Drugs, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Cheng Y; Research Center for Marine Drugs, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Li M; Research Center for Marine Drugs, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Zhou L; Research Center for Marine Drugs, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Hong LL; Research Center for Marine Drugs, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Deng H; Department of Chemistry, University of Aberdeen, Aberdeen, AB24 3UE, UK.
Lin HW; Research Center for Marine Drugs, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. .
Zhou Y; Research Center for Marine Drugs, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. .
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Source:
Microbial cell factories [Microb Cell Fact] 2024 Mar 21; Vol. 23 (1), pp. 87. Date of Electronic Publication: 2024 Mar 21.
Publication Type:
Journal Article
MeSH Terms:
Biosynthetic Pathways*
Polyketide Synthases*/metabolism
Pyrrolidinones*
Bacteria/metabolism ; Pyrans/metabolism ; Skeleton/metabolism ; Peptide Synthases/genetics
Academic Journal
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Title:
The Effect of 4-(Dimethylamino)phenyl-5-oxopyrrolidines on Breast and Pancreatic Cancer Cell Colony Formation, Migration, and Growth of Tumor Spheroids.
Authors:
Kairytė K; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Vaickelionienė R; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Grybaitė B; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Anusevičius K; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Mickevičius V; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Petrikaitė V; Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio Al. 7, LT-10257 Vilnius, Lithuania.; Faculty of Medicine, Lithuanian University of Health Sciences, A. Mickevičiaus 9, LT-44307 Kaunas, Lithuania.; Laboratory of Drug Targets Histopathology, Institute of Cardiology, Lithuanian University of Health Sciences, Sukilėlių Pr. 13, LT-50162 Kaunas, Lithuania.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 02; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 02.
Publication Type:
Journal Article
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/pathology
Triple Negative Breast Neoplasms*/drug therapy
Humans ; Structure-Activity Relationship ; Cell Proliferation ; Hydrazones/pharmacology ; Pyrrolidinones/pharmacology ; Cell Line, Tumor
Academic Journal
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Title:
Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer's agents: synthesis, in-silico and pharmacological evaluations.
Authors:
Gupta M; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India.
Pant S; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India.
Rana P; Department of Medicinal Chemistry, National Institute for Pharmaceutical Education and Research (NIPER) Balangar, Hyderabad, India.
Kumar A; Department of Medical Affairs, Curie Sciences Pvt. Ltd., Samastipur, Bihar, 848125, India.
Prasun C; Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Nair MS; Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Paliwal S; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India.
Nain S; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India. .
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Source:
Scientific reports [Sci Rep] 2024 Jan 19; Vol. 14 (1), pp. 1687. Date of Electronic Publication: 2024 Jan 19.
Publication Type:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Quinolines*
Pyridines*
Sulfonamides*
Animals ; Donepezil/pharmacology ; Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Structure-Activity Relationship ; Quantitative Structure-Activity Relationship ; Pyrrolidinones ; Molecular Docking Simulation
Academic Journal
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Title:
Synthesis and In Vitro Evaluation as Potential Anticancer and Antioxidant Agents of Diphenylamine-Pyrrolidin-2-one-Hydrazone Derivatives.
Authors:
Zubrickė I; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, Lithuania.
Jonuškienė I; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, Lithuania.
Kantminienė K; Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, Lithuania.
Tumosienė I; Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, Lithuania.
Petrikaitė V; Laboratory of Drug Targets Histopathology, Institute of Cardiology, Lithuanian University of Health Sciences, Sukilėlių pr. 13, 50162 Kaunas, Lithuania.; Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio al. 7, 10257 Vilnius, Lithuania.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 27; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 27.
Publication Type:
Journal Article
MeSH Terms:
Melanoma*
Triple Negative Breast Neoplasms*/drug therapy
Antineoplastic Agents*/pharmacology
Prostatic Neoplasms*
Male ; Humans ; Antioxidants/pharmacology ; Hydrazones/pharmacology ; Diphenylamine/pharmacology ; Cell Proliferation ; Pyrrolidinones/pharmacology ; Pyrrolidines/pharmacology ; Structure-Activity Relationship ; Cell Line, Tumor
Academic Journal
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Title:
The Antidepressant Activity of a Taurine-Containing Derivative of 4-Phenylpyrrolidone-2 in a Model of Chronic Unpredictable Mild Stress.
Authors:
Borozdenko DA; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Gonchar DI; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Bogorodova VI; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Tarasenko DV; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Kramarova EP; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Khovanova SS; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Golubev YV; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Kiseleva NM; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Shmigol TA; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Ezdoglian AA; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Sobyanin KA; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Negrebetsky VV; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Baukov YI; Institute of Pharmacy and Medicinal Chemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 21; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 21.
Publication Type:
Journal Article
MeSH Terms:
Fluoxetine*/pharmacology
Fluoxetine*/therapeutic use
Antidepressive Agents*/pharmacology
Antidepressive Agents*/therapeutic use
Rats ; Male ; Animals ; Rats, Wistar ; Pyrrolidinones/pharmacology ; Depression/drug therapy ; Depression/etiology ; Stress, Psychological/drug therapy ; Corticosterone ; Disease Models, Animal ; Behavior, Animal
Academic Journal
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Title:
Bioactive Compounds from an Endophytic Pezicula sp. Showing Antagonistic Effects against the Ash Dieback Pathogen.
Authors:
Demir Ö; Department Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Zeng H; Department Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Schulz B; Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
Schrey H; Department Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.; Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
Steinert M; Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
Stadler M; Department Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.; Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
Surup F; Department Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.; Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
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Source:
Biomolecules [Biomolecules] 2023 Nov 08; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 08.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Staphylococcus aureus*
Antifungal Agents*
Pyrrolidinones/pharmacology
SCR Organism:
Pezicula ericae
Academic Journal
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Title:
A Catalyst and Solvent Free Route for the Synthesis of N-Substituted Pyrrolidones from Levulinic Acid.
Authors:
Dolui P; Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India.
Tiwari V; Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India.
Saini P; Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India.
Karmakar T; Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India.
Makhal K; Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India.
Goel H; Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India.
Elias AJ; Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India.
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Source:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Aug 01; Vol. 28 (43), pp. e202200829. Date of Electronic Publication: 2022 Jun 16.
Publication Type:
Journal Article
MeSH Terms:
Pyrrolidinones*
Amination ; Catalysis ; Levulinic Acids ; Solvents
Academic Journal
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Title:
Evaluation of Chiral Liquid Chromatographic Method for Separation and Quantification of Isomers of Brivaracetam.
Authors:
Choppari T; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.
Gunnam S; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.
Chennuru LN; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.
Cherla PM; Department of Chemistry, University college of science, Osmania University campus, Hyderabad-500007, Telangana, India.
Talluri MVNK; Analytical & Separation Services, Daicel Chiral Technologies (India) Pvt Ltd, Survey No. 542/2, IKP Knowledge Park, Turkapally, Shamirpet Mandal, Medchal-Malkajgiri District, Hyderabad-500101, Telangana, India.
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Source:
Journal of chromatographic science [J Chromatogr Sci] 2022 Mar 23; Vol. 60 (3), pp. 250-259.
Publication Type:
Journal Article
MeSH Terms:
Pyrrolidinones*
Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Isomerism ; Stereoisomerism
Academic Journal
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Title:
Anti-Pathogenic Properties of the Combination of a T3SS Inhibitory Halogenated Pyrrolidone with C-30 Furanone.
Authors:
Aburto-Rodríguez NA; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Muñoz-Cázares N; Laboratorio de Fitoquímica, Posgrado de Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico.
Castro-Torres VA; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
González-Pedrajo B; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico.
Díaz-Guerrero M; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico.
García-Contreras R; Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Quezada H; Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de Mexico 06720, Mexico.
Castillo-Juárez I; Laboratorio de Fitoquímica, Posgrado de Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico.
Martínez-Vázquez M; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2021 Dec 16; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 16.
Publication Type:
Journal Article
MeSH Terms:
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Furans*/chemistry
Furans*/pharmacology
Hydrocarbons, Halogenated*/chemistry
Hydrocarbons, Halogenated*/pharmacology
Pseudomonas Infections*/drug therapy
Pseudomonas Infections*/metabolism
Pseudomonas aeruginosa*/growth & development
Pseudomonas aeruginosa*/pathogenicity
Pyrrolidinones*/chemistry
Pyrrolidinones*/pharmacology
Type III Secretion Systems/*antagonists & inhibitors
Animals ; Humans ; Mice ; Necrosis ; Quorum Sensing/drug effects ; Type III Secretion Systems/metabolism ; Virulence Factors/metabolism
Academic Journal
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Title:
Effect of N-Vinyl-2-Pyrrolidone (NVP), a Bromodomain-Binding Small Chemical, on Osteoblast and Osteoclast Differentiation and Its Potential Application for Bone Regeneration.
Authors:
Klemmer VA; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Khera N; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Siegenthaler BM; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Bhattacharya I; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Weber FE; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.; Center for Applied Biotechnology and Molecular Medicine, University of Zurich, 8057 Zurich, Switzerland.
Ghayor C; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 13; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 13.
Publication Type:
Journal Article
MeSH Terms:
Bone Regeneration/*drug effects
Cell Differentiation/*drug effects
Pyrrolidinones/*pharmacology
Animals ; Bone Diseases/drug therapy ; Bone Diseases/pathology ; Bone Morphogenetic Protein 2/agonists ; Bone Morphogenetic Protein 2/metabolism ; Bone and Bones/pathology ; Cell Survival/drug effects ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/metabolism ; Disease Models, Animal ; Mice ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteoclasts/cytology ; Osteoclasts/metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Pyrrolidinones/chemistry ; Pyrrolidinones/therapeutic use ; RANK Ligand/pharmacology ; Rabbits ; Smad1 Protein/metabolism
Academic Journal
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Title:
Five Tetramic Acid Derivatives Isolated from the Iranian Fungus Colpoma   quercinum CCTU A372.
Authors:
Primahana G; Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.; Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong, 15314 Tangerang Selatan, Indonesia.
Narmani A; Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.; Department of Plant Protection, Faculty of Agriculture, University of Tabriz, Tabriz 51666, Iran.
Surup F; Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Teponno RB; Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Arzanlou M; Department of Plant Protection, Faculty of Agriculture, University of Tabriz, Tabriz 51666, Iran.
Stadler M; Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.
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Source:
Biomolecules [Biomolecules] 2021 May 22; Vol. 11 (6). Date of Electronic Publication: 2021 May 22.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyrrolidinones*/chemistry
Pyrrolidinones*/isolation & purification
Pyrrolidinones*/pharmacology
Ascomycota/*chemistry
Bacillus subtilis/*growth & development
Mucor/*growth & development
Mycelium/*chemistry
Anti-Infective Agents/chemistry ; Anti-Infective Agents/isolation & purification ; Anti-Infective Agents/pharmacology ; Iran
SCR Organism:
Colpoma quercinum; Mucor hiemalis
Academic Journal
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Title:
Synaptic density in carriers of C9orf72 mutations: a [ C]UCB-J PET study.
Authors:
Malpetti M; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Holland N; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Jones PS; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Ye R; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Cope TE; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK.
Fryer TD; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Hong YT; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Savulich G; Department of Psychiatry, University of Cambridge, Cambridge, UK.
Rittman T; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Passamonti L; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Consiglio Nazionale delle Ricerche (CNR), Milano, Italy.
Mak E; Department of Psychiatry, University of Cambridge, Cambridge, UK.
Aigbirhio FI; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
O'Brien JT; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK.
Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK.
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Source:
Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2021 Jul; Vol. 8 (7), pp. 1515-1523. Date of Electronic Publication: 2021 Jun 16.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyridines*/metabolism
Pyrrolidinones*/metabolism
C9orf72 Protein/*genetics
Frontotemporal Dementia/*genetics
Mutation/*genetics
Positron-Emission Tomography/*methods
Synapses/*genetics
C9orf72 Protein/metabolism ; Carbon Radioisotopes/metabolism ; Female ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/metabolism ; Heterozygote ; Humans ; Male ; Middle Aged ; Synapses/metabolism
Academic Journal
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Title:
Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway.
Authors:
Ni Z; School of Public Health/MOE Key Laboratory for Public Health Safety/NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
Sun W; School of Public Health/MOE Key Laboratory for Public Health Safety/NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
Li R; Shanghai Institute for Food and Drug Control, Shanghai, 201203, China.
Yang M; NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai, 200032, China.
Zhang F; School of Public Health/MOE Key Laboratory for Public Health Safety/NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
Chang X; School of Public Health/MOE Key Laboratory for Public Health Safety/NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
Li W; NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai, 200032, China.
Zhou Z; School of Public Health/MOE Key Laboratory for Public Health Safety/NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China. .
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Source:
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2021 Apr 26; Vol. 19 (1), pp. 64. Date of Electronic Publication: 2021 Apr 26.
Publication Type:
Journal Article
MeSH Terms:
Autophagy/*drug effects
Endocrine Disruptors/*pharmacology
Herbicides/*pharmacology
Proto-Oncogene Proteins c-akt/*physiology
Pyrrolidinones/*pharmacology
Sertoli Cells/*drug effects
Signal Transduction/*physiology
TOR Serine-Threonine Kinases/*physiology
Acetates/pharmacology ; Acetylcysteine/pharmacology ; Animals ; Autophagy/physiology ; Benzopyrans/pharmacology ; Cell Shape ; Herbicides/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Pyrrolidinones/toxicity ; Random Allocation ; Reactive Oxygen Species ; Sertoli Cells/cytology ; Sertoli Cells/metabolism ; Spermatozoa/drug effects ; Spermatozoa/ultrastructure
Academic Journal
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Title:
Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase.
Authors:
Afzal O; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Altamimi ASA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Shahroz MM; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore 466001, Madhya Pradesh, India.
Sharma HK; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore 466001, Madhya Pradesh, India.
Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Hassan MQ; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 20; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 20.
Publication Type:
Journal Article
MeSH Terms:
Antineoplastic Agents/*chemistry
Benzoxazoles/*chemistry
Monoacylglycerol Lipases/*antagonists & inhibitors
Pyrrolidinones/*pharmacology
Analgesics/chemistry ; Analgesics/pharmacology ; Antineoplastic Agents/pharmacology ; Benzoxazoles/pharmacology ; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Humans ; Molecular Docking Simulation ; Monoacylglycerol Lipases/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology ; Pyrrolidinones/chemistry ; Structure-Activity Relationship
Academic Journal
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Title:
Brivaracetam: How Well Does It Fare as an Anti-Epileptic? A Review.
Authors:
Khilari M; Consultant Neurologist, Apollo Health City, Jubilee Hills, Hyderabad, Telangana, India.
Nair PP; Department of Neurology, JIPMER, Puducherry, India.
Jha BK; Lead - Scientific writing, Indegene Pvt Ltd., Nagwara, Bangalore, India.
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Source:
Neurology India [Neurol India] 2021 Mar-Apr; Vol. 69 (2), pp. 284-293.
Publication Type:
Journal Article; Meta-Analysis; Review
MeSH Terms:
Anticonvulsants*/therapeutic use
Pyrrolidinones*/therapeutic use
Drug Therapy, Combination ; Humans ; Seizures/drug therapy
Academic Journal
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Title:
Engineering of an ene-reductase for producing the key intermediate of antiepileptic drug Brivaracetam.
Authors:
Sun L; Department of Chemistry, Shanghai University, Shangda Road 99, Shanghai, China.
Liu Y; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Song H; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Ling Ling Road 345, Shanghai, China.
Hao J; Department of Chemistry, Shanghai University, Shangda Road 99, Shanghai, China.
Lin L; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and College of Chemistry and Molecular Engineering, Peking University, Beijing, China. .
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Source:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2023 Mar; Vol. 107 (5-6), pp. 1649-1661. Date of Electronic Publication: 2023 Jan 30.
Publication Type:
Journal Article
MeSH Terms:
Oxidoreductases*/genetics
Anticonvulsants*
Pyrrolidinones ; Mutagenesis
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
A healthy outcome of a pregnant woman with drug-resistant juvenile myoclonic epilepsy treated with brivaracetam.
Authors:
Navarro CE; Unit of Clinical Neurology, School of Medicine, Universidad Nacional de Colombia, Ciudad Universitaria carrera 30 # 45-03, 111321, Bogotá, Colombia. .; Grupo de Investigación en Neurología de la Universidad Nacional de Colombia-NeuroUnal, Bogotá, Colombia. .; Medical Cannabis and Drug-Resistant Epilepsy Program, Clínica Zerenia, Bogotá, Colombia. .
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Source:
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 Feb; Vol. 44 (2), pp. 753-755. Date of Electronic Publication: 2022 Oct 12.
Publication Type:
Letter
MeSH Terms:
Myoclonic Epilepsy, Juvenile*/drug therapy
Female ; Pregnancy ; Humans ; Pregnant Women ; Pyrrolidinones/therapeutic use ; Anticonvulsants/therapeutic use ; Treatment Outcome
Editorial & Opinion
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Title:
Impact of SMTP Targeting Plasminogen and Soluble Epoxide Hydrolase on Thrombolysis, Inflammation, and Ischemic Stroke.
Authors:
Hasumi K; Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.; Division of Research and Development, TMS Co., Ltd., Tokyo 183-0023, Japan.
Suzuki E; Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 19; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 19.
Publication Type:
Journal Article; Review
MeSH Terms:
Benzopyrans/*pharmacology
Inflammation/*drug therapy
Ischemic Stroke/*drug therapy
Pyrrolidinones/*pharmacology
Thrombolytic Therapy/*methods
Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Benzopyrans/therapeutic use ; Brain Ischemia/blood ; Brain Ischemia/drug therapy ; Brain Ischemia/pathology ; Epoxide Hydrolases/drug effects ; Epoxide Hydrolases/metabolism ; Fibrinolysis/drug effects ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Humans ; Inflammation/blood ; Inflammation/pathology ; Ischemic Stroke/blood ; Ischemic Stroke/pathology ; Plasminogen/drug effects ; Plasminogen/metabolism ; Pyrrolidinones/therapeutic use ; Stachybotrys/chemistry ; Stachybotrys/metabolism
SCR Organism:
Stachybotrys microspora
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Showing 1-20 from 2483 results

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