Temat: "Pyrrolidinones" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Aniracetam does not improve working memory in neurologically healthy pigeons.
Autorzy:: Phillips H; Department of Psychology, University of Otago, Dunedin, Otago, New Zealand.
McDowell A; School of Pharmacy, University of Otago, Dunedin, Otago, New Zealand.
Mielby BS; School of Pharmacy, University of Otago, Dunedin, Otago, New Zealand.
Tucker IG; School of Pharmacy, University of Otago, Dunedin, Otago, New Zealand.
Colombo M; Department of Psychology, University of Otago, Dunedin, Otago, New Zealand.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Apr 19; Vol. 14 (4), pp. e0215612. Date of Electronic Publication: 2019 Apr 19 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*drug effects
Columbidae/*physiology
Memory, Short-Term/*drug effects
Pyrrolidinones/*pharmacology
Administration, Oral ; Animals ; Brain/physiology ; Cognition/drug effects ; Cognition/physiology ; Injections, Intramuscular ; Memory, Short-Term/physiology ; Nootropic Agents/administration & dosage ; Nootropic Agents/pharmacokinetics ; Nootropic Agents/pharmacology ; Psychomotor Performance/drug effects ; Pyrrolidinones/administration & dosage ; Pyrrolidinones/pharmacokinetics ; Time Factors

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Skocz do pozycji: 2.

Tytuł:: Amelioration of sexual behavior and motor activity deficits in a castrated rodent model with a selective androgen receptor modulator SARM-2f.
Autorzy:: Morimoto M; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Amano Y; CVM Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Oka M; CVM Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Harada A; CVM Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Fujita H; DMPK Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Hikichi Y; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Tozawa R; CVM Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Yamaoka M; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Hara T; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Dec 07; Vol. 12 (12), pp. e0189480. Date of Electronic Publication: 2017 Dec 07 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Motor Activity*
Orchiectomy*
Sexual Behavior, Animal*
Pyrrolidinones/*pharmacology
Receptors, Androgen/*drug effects
Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Pyrrolidinones/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Androgen/physiology ; Tissue Distribution ; Transcription, Genetic

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Skocz do pozycji: 3.

Tytuł:: Identification of antibiotics for use in selection of the chytrid fungi Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans.
Autorzy:: Robinson KA; Department of Biology, The University of Massachusetts Amherst, Amherst, MA, United States of America.
Dunn M; Department of Biology, The University of Massachusetts Amherst, Amherst, MA, United States of America.
Hussey SP; Department of Biology, The University of Massachusetts Amherst, Amherst, MA, United States of America.
Fritz-Laylin LK; Department of Biology, The University of Massachusetts Amherst, Amherst, MA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Oct 20; Vol. 15 (10), pp. e0240480. Date of Electronic Publication: 2020 Oct 20 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Amphibians/*microbiology
Antifungal Agents/*pharmacology
Batrachochytrium/*drug effects
Batrachochytrium/*growth & development
Mycology/*methods
Animals ; Batrachochytrium/genetics ; Bleomycin/pharmacology ; Cinnamates/pharmacology ; Diagnostic Tests, Routine ; Drug Evaluation, Preclinical ; Hygromycin B/analogs & derivatives ; Hygromycin B/pharmacology ; Microbial Sensitivity Tests ; Neomycin/pharmacology ; Puromycin/pharmacology ; Pyrrolidinones/pharmacology ; Selection, Genetic

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Skocz do pozycji: 4.

Tytuł:: Restricting extracellular Ca2+ on gefitinib-resistant non-small cell lung cancer cells reverses altered epidermal growth factor-mediated Ca2+ response, which consequently enhances gefitinib sensitivity.
Autorzy:: Kim MS; Department of Oral Physiology, Institute of Biomaterial-Implant, School of Dentistry, Wonkwang University, Iksan, Republic of Korea.; Wonkwang Dental Research Institute, School of Dentistry, Wonkwang University, Iksan, Republic of Korea.
Kim SH; Department of Carbon Convergence Engineering, College of Engineering, Wonkwang University, Iksan, Republic of Korea.
Yang SH; Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Republic of Korea.
Kim MS; Department of Oral Physiology, Institute of Biomaterial-Implant, School of Dentistry, Wonkwang University, Iksan, Republic of Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Aug 25; Vol. 15 (8), pp. e0238155. Date of Electronic Publication: 2020 Aug 25 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium Signaling*/drug effects
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Carcinoma, Non-Small-Cell Lung/*metabolism
Epidermal Growth Factor/*metabolism
Gefitinib/*pharmacology
Lung Neoplasms/*drug therapy
Lung Neoplasms/*metabolism
Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Epidermal Growth Factor/pharmacology ; ErbB Receptors/metabolism ; Estrenes/pharmacology ; Humans ; NFATC Transcription Factors/biosynthesis ; Pyrrolidinones/pharmacology ; Type C Phospholipases/antagonists & inhibitors

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Skocz do pozycji: 5.

Tytuł:: Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase.
Autorzy:: Larson EC; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, United States of America.
Lim AL; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, United States of America.
Pond CD; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, United States of America.
Craft M; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America.
Čavužić M; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America.
Waldrop GL; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America.
Schmidt EW; Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, United States of America.
Barrows LR; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 May 29; Vol. 15 (5), pp. e0233485. Date of Electronic Publication: 2020 May 29 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Acetyl-CoA Carboxylase/*antagonists & inhibitors
Bacterial Proteins/*antagonists & inhibitors
Gram-Positive Bacteria/*drug effects
Gram-Positive Bacteria/*metabolism
Pyrrolidinones/*pharmacology
Tetrahydronaphthalenes/*pharmacology
Acetyl-CoA Carboxylase/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/chemistry ; Catalytic Domain/drug effects ; Energy Metabolism/drug effects ; Fatty Acids/biosynthesis ; Gene Expression Profiling ; Gram-Positive Bacteria/growth & development ; Humans ; Metabolomics ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/metabolism ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/growth & development ; Staphylococcus aureus/metabolism

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Skocz do pozycji: 6.

Tytuł:: Comparison of illumina and 454 deep sequencing in participants failing raltegravir-based antiretroviral therapy.
Autorzy:: Li JZ; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Chapman B; Harvard School of Public Health, Boston, Massachusetts, United States of America.
Charlebois P; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Hofmann O; Harvard School of Public Health, Boston, Massachusetts, United States of America.
Weiner B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Porter AJ; Harvard School of Public Health, Boston, Massachusetts, United States of America.
Samuel R; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Department of Virology, University of KwaZulu-Natal, National Health Laboratory Service, Durban, South Africa.
Vardhanabhuti S; Harvard School of Public Health, Boston, Massachusetts, United States of America.
Zheng L; Harvard School of Public Health, Boston, Massachusetts, United States of America.
Eron J; Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Taiwo B; Division of Infectious Diseases, Northwestern University, Chicago, Illinois, United States of America.
Zody MC; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Henn MR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Kuritzkes DR; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Hide W; Harvard School of Public Health, Boston, Massachusetts, United States of America.
Wilson CC; University of Colorado.
Berzins BI; Northwestern University.
Acosta EP; University of Alabama at Birmingham.
Bastow B; ACTG Operations Center, Social & Scientific Systems, Inc.
Kim PS; National Institute of Allergy and Infectious Diseases.
Read SW; National Institute of Allergy and Infectious Diseases.
Janik J; Frontier Science & Technology Research Foundation.
Meres DS; National Institute of Allergy and Infectious Diseases.
Lederman MM; Case Western Reserve University.
Mong-Kryspin L; Ohio State University.
Shaw KE; Henry Ford Hospital CRS.
Zimmerman LG; University of Colorado CRS.
Leavitt R; Merck.
De La Rosa G; Tibotec.
Jennings A; ACTG Operations Center.; Pokaż więcej
Corporate Authors:: ACTG A5262 Study Team
Źródło:: PloS one [PLoS One] 2014 Mar 06; Vol. 9 (3), pp. e90485. Date of Electronic Publication: 2014 Mar 06 (Print Publication: 2014).
Typ publikacji:: Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Mutation*
Anti-HIV Agents/*pharmacology
HIV Infections/*drug therapy
HIV-1/*drug effects
HIV-1/*genetics
High-Throughput Nucleotide Sequencing/*methods
Pyrrolidinones/*pharmacology
Drug Resistance, Viral/genetics ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Pyrrolidinones/therapeutic use ; Raltegravir Potassium ; Treatment Failure

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Skocz do pozycji: 7.

Tytuł:: Effects of switching from stavudine to raltegravir on subcutaneous adipose tissue in HIV-infected patients with HIV/HAART-associated lipodystrophy syndrome (HALS). A clinical and molecular study.
Autorzy:: Domingo P; Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Gutierrez Mdel M; Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Gallego-Escuredo JM; Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Fisiopatología de la Obesidad y Nutrición, Centros de Investigación Biomédica en Red (CIBER), Santiago de Compostela, Spain.
Torres F; Biostatistics and Data Management Platform, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Mateo GM; Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Villarroya J; Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Institut de Recerca del Hospital de la Santa Creu i Sant Pau, Barcelona, Spain ; Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Fisiopatología de la Obesidad y Nutrición, Centros de Investigación Biomédica en Red (CIBER), Santiago de Compostela, Spain.
de los Santos I; Infectious Diseases Unit, Hospital de la Princesa, Madrid, Spain.
Domingo JC; Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Fisiopatología de la Obesidad y Nutrición, Centros de Investigación Biomédica en Red (CIBER), Santiago de Compostela, Spain.
Villarroya F; Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Fisiopatología de la Obesidad y Nutrición, Centros de Investigación Biomédica en Red (CIBER), Santiago de Compostela, Spain.
Del Rio L; CETIR, Barcelona, Spain.
Estrada V; Infectious Diseases Unit, Hospital Clínico de San Carlos, Madrid, Spain.
Giralt M; Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Institute of Biomedicine, University of Barcelona, Barcelona, Spain ; Fisiopatología de la Obesidad y Nutrición, Centros de Investigación Biomédica en Red (CIBER), Santiago de Compostela, Spain.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Feb 26; Vol. 9 (2), pp. e89088. Date of Electronic Publication: 2014 Feb 26 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
Lipodystrophy/*chemically induced
Pyrrolidinones/*therapeutic use
Stavudine/*therapeutic use
Subcutaneous Fat/*drug effects
Adult ; Anti-HIV Agents/adverse effects ; Body Composition ; DNA, Mitochondrial/metabolism ; Female ; Gene Expression ; Humans ; Lipodystrophy/genetics ; Male ; Middle Aged ; Pyrrolidinones/adverse effects ; Raltegravir Potassium ; Stavudine/adverse effects ; Subcutaneous Fat/metabolism

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Skocz do pozycji: 8.

Tytuł:: Switching tenofovir/emtricitabine plus lopinavir/r to raltegravir plus Darunavir/r in patients with suppressed viral load did not result in improvement of renal function but could sustain viral suppression: a randomized multicenter trial.
Autorzy:: Nishijima T; AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
Gatanaga H
Shimbo T
Komatsu H
Endo T
Horiba M
Koga M
Naito T
Itoda I
Tei M
Fujii T
Takada K
Yamamoto M
Miyakawa T
Tanabe Y
Mitsuya H
Oka S; Pokaż więcej
Corporate Authors:: SPARE study team
Źródło:: PloS one [PLoS One] 2013 Aug 08; Vol. 8 (8), pp. e73639. Date of Electronic Publication: 2013 Aug 08 (Print Publication: 2013).
Typ publikacji:: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenine/*analogs & derivatives
Anti-HIV Agents/*therapeutic use
Deoxycytidine/*analogs & derivatives
HIV Infections/*drug therapy
HIV-1/*drug effects
Lopinavir/*therapeutic use
Organophosphonates/*therapeutic use
Pyrrolidinones/*therapeutic use
Sulfonamides/*therapeutic use
Adenine/adverse effects ; Adenine/therapeutic use ; Adult ; Anti-HIV Agents/adverse effects ; Darunavir ; Deoxycytidine/adverse effects ; Deoxycytidine/therapeutic use ; Emtricitabine ; Female ; Humans ; Kidney/drug effects ; Kidney/physiology ; Kidney Function Tests ; Lopinavir/adverse effects ; Male ; Middle Aged ; Organophosphonates/adverse effects ; Pyrrolidinones/adverse effects ; Raltegravir Potassium ; Sulfonamides/adverse effects ; Tenofovir ; Viral Load/drug effects

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Skocz do pozycji: 9.

Tytuł:: Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids.
Autorzy:: Brosnahan AJ; Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Merriman JA
Salgado-Pabón W
Ford B
Schlievert PM; Pokaż więcej
Źródło:: PloS one [PLoS One] 2013 Apr 22; Vol. 8 (4), pp. e61255. Date of Electronic Publication: 2013 Apr 22 (Print Publication: 2013).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Bacterial Toxins/*pharmacology
Enterococcus faecalis/*physiology
Enterotoxins/*pharmacology
Epithelial Cells/*metabolism
Interleukin-8/*metabolism
Pyrrolidinones/*metabolism
Superantigens/*pharmacology
Vagina/*cytology
Cell Proliferation/drug effects ; Chemical Precipitation ; Deoxyribonucleases/metabolism ; Enterococcus faecalis/immunology ; Enterococcus faecalis/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/immunology ; Epithelial Cells/microbiology ; Ethanol/chemistry ; Female ; Humans ; Interleukin-8/biosynthesis ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/drug effects ; Molecular Weight ; Peptide Hydrolases/metabolism ; Pyrrolidinones/chemistry ; Ribonucleases/metabolism ; Vagina/microbiology ; Young Adult

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Skocz do pozycji: 10.

Tytuł:: Population-based input function modeling for [(18)F]FMPEP-d 2, an inverse agonist radioligand for cannabinoid CB1 receptors: validation in clinical studies.
Autorzy:: Zanotti-Fregonara P; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Hirvonen J
Lyoo CH
Zoghbi SS
Rallis-Frutos D
Huestis MA
Morse C
Pike VW
Innis RB; Pokaż więcej
Źródło:: PloS one [PLoS One] 2013; Vol. 8 (4), pp. e60231. Date of Electronic Publication: 2013 Apr 05.
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural; Validation Study
MeSH Terms:: Drug Inverse Agonism*
Models, Biological*
Pyrrolidinones/*metabolism
Receptor, Cannabinoid, CB1/*agonists
Receptor, Cannabinoid, CB1/*metabolism
Alcoholism/diagnostic imaging ; Alcoholism/metabolism ; Cannabis ; Female ; Humans ; Kinetics ; Ligands ; Male ; Positron-Emission Tomography ; Pyrrolidinones/pharmacology ; Smoking/metabolism

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Skocz do pozycji: 11.

Tytuł:: Unprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravir.
Autorzy:: Ammar FF; LBPA, UMR8113 du CNRS, Ecole Normale Supérieure de Cachan, Cedex, Cachan, France.
Abdel-Azeim S
Zargarian L
Hobaika Z
Maroun RG
Fermandjian S; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (7), pp. e40223. Date of Electronic Publication: 2012 Jul 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV Long Terminal Repeat*
DNA, Viral/*chemistry
HIV Integrase/*chemistry
HIV Integrase Inhibitors/*chemistry
HIV-1/*enzymology
Pyrrolidinones/*chemistry
Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/enzymology ; Humans ; Pyrrolidinones/therapeutic use ; Raltegravir Potassium

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Skocz do pozycji: 12.

Tytuł:: Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome.
Autorzy:: Singh IR; Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America. />Gorzynski JE
Drobysheva D
Bassit L
Schinazi RF; Pokaż więcej
Źródło:: PloS one [PLoS One] 2010 Apr 01; Vol. 5 (4), pp. e9948. Date of Electronic Publication: 2010 Apr 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Drug Evaluation, Preclinical/*methods
Fatigue Syndrome, Chronic/*virology
Gammaretrovirus/*drug effects
Prostatic Neoplasms/*virology
Pyrrolidinones/*pharmacology
Retroviridae Infections/*drug therapy
Tumor Virus Infections/*drug therapy
Antiviral Agents ; Cell Line, Tumor ; Female ; Humans ; Leukemia Virus, Murine/drug effects ; Male ; Microbial Sensitivity Tests ; Pyrrolidinones/therapeutic use ; Raltegravir Potassium ; Virus Replication/drug effects

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Skocz do pozycji: 13.

Tytuł:: ARQ-197, a small-molecule inhibitor of c-Met, reduces tumour burden and prevents myeloma-induced bone disease in vivo.
Autorzy:: Lath DL; Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom.
Buckle CH; Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom.
Evans HR; Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom.
Fisher M; Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.
Down JM; Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom.
Lawson MA; Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom.
Chantry AD; Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom.; Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, United Kingdom.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Jun 20; Vol. 13 (6), pp. e0199517. Date of Electronic Publication: 2018 Jun 20 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Bone Diseases/*prevention & control
Multiple Myeloma/*drug therapy
Proto-Oncogene Proteins c-met/*antagonists & inhibitors
Pyrrolidinones/*pharmacology
Quinolines/*pharmacology
Animals ; Bone Diseases/diagnostic imaging ; Bone Diseases/metabolism ; Bone Diseases/pathology ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Female ; Humans ; Mice, Inbred NOD ; Mice, SCID ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Neoplasm Transplantation ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Osteoclasts/pathology ; Proto-Oncogene Proteins c-met/metabolism ; Random Allocation ; Tumor Burden/drug effects

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Skocz do pozycji: 14.

Tytuł:: The role of SeDeM for characterizing the active substance and polyvinyilpyrrolidone eliminating metastable forms in an oral lyophilizate—A preformulation study.
Autorzy:: Flórez Borges, Paloma
García-Montoya, Encarna
Pérez-Lozano, Pilar
Jo, Enric
Miñarro, Montserrat
Manich, Albert
Suñé-Negre, Josep Maria; Pokaż więcej
Źródło:: PLoS ONE. 4/24/2018, Vol. 13 Issue 4, p1-17. 17p.

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Skocz do pozycji: 15.

Tytuł:: A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.
Autorzy:: Yashiro H; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.
Takagahara S; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.
Tamura YO; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.
Miyahisa I; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.
Matsui J; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.
Suzuki H; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.
Ikeda S; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.
Watanabe M; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Nov 10; Vol. 11 (11), pp. e0166198. Date of Electronic Publication: 2016 Nov 10 (Print Publication: 2016).
Typ publikacji:: Journal Article
MeSH Terms:: Insulin Resistance*
Body Weight/*drug effects
Enzyme Inhibitors/*pharmacology
Fatty Acid Desaturases/*antagonists & inhibitors
Obesity/*prevention & control
Pyrimidinones/*pharmacology
Pyrrolidinones/*pharmacology
8,11,14-Eicosatrienoic Acid/blood ; 8,11,14-Eicosatrienoic Acid/metabolism ; Adiponectin/genetics ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; Arachidonic Acid/blood ; Arachidonic Acid/metabolism ; Delta-5 Fatty Acid Desaturase ; Diet, High-Fat/adverse effects ; Energy Metabolism/drug effects ; Fatty Acid Desaturases/metabolism ; Gene Expression/drug effects ; Hep G2 Cells ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/prevention & control ; Leptin/genetics ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Obesity/etiology ; Obesity/physiopathology ; Reverse Transcriptase Polymerase Chain Reaction ; Weight Loss/drug effects

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Skocz do pozycji: 16.

Tytuł:: Development of a Microemulsion Formulation for Antimicrobial SecA Inhibitors.
Autorzy:: Hu J; Citrus Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Lake Alfred, Florida, United States of America.
Akula N; Citrus Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Lake Alfred, Florida, United States of America.
Wang N; Citrus Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Lake Alfred, Florida, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Mar 10; Vol. 11 (3), pp. e0150433. Date of Electronic Publication: 2016 Mar 10 (Print Publication: 2016).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenosine Triphosphatases/*antagonists & inhibitors
Anti-Infective Agents/*chemistry
Anti-Infective Agents/*pharmacology
Bacteria/*growth & development
Bacterial Proteins/*antagonists & inhibitors
Dimethyl Sulfoxide/chemistry ; Dimethyl Sulfoxide/pharmacology ; Emulsions ; Membrane Transport Proteins ; Pyrrolidinones/chemistry ; Pyrrolidinones/pharmacology ; SEC Translocation Channels ; SecA Proteins ; Surface-Active Agents/chemistry ; Surface-Active Agents/pharmacology

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Skocz do pozycji: 17.

Tytuł:: Baculovirus IE2 Stimulates the Expression of Heat Shock Proteins in Insect and Mammalian Cells to Facilitate Its Proper Functioning.
Autorzy:: Tung H; Molecular and Biological Agricultural Sciences, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan, and National Chung Hsing University, Taichung, Taiwan.; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan.
Wei SC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Lo HR; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Chao YC; Molecular and Biological Agricultural Sciences, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan, and National Chung Hsing University, Taichung, Taiwan.; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.; Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Feb 10; Vol. 11 (2), pp. e0148578. Date of Electronic Publication: 2016 Feb 10 (Print Publication: 2016).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Host-Pathogen Interactions*
Heat-Shock Proteins/*biosynthesis
Immediate-Early Proteins/*physiology
Nucleopolyhedroviruses/*physiology
Trans-Activators/*physiology
Amino Acid Sequence ; Animals ; Benzhydryl Compounds/pharmacology ; Chlorocebus aethiops ; Gene Expression Profiling ; Gene Expression Regulation, Viral ; Genes, Reporter ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/physiology ; Inclusion Bodies, Viral ; Intranuclear Inclusion Bodies ; Leupeptins/pharmacology ; Molecular Sequence Data ; Nucleopolyhedroviruses/genetics ; Proteasome Endopeptidase Complex/metabolism ; Pyrrolidinones/pharmacology ; RNA Interference ; Sf9 Cells ; Spodoptera ; Up-Regulation ; Vero Cells ; Virus Replication

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Skocz do pozycji: 18.

Tytuł:: Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
Autorzy:: Montalbano A; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Corradetti R; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Mlinar B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Oct 13; Vol. 10 (10), pp. e0140369. Date of Electronic Publication: 2015 Oct 13 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dorsal Raphe Nucleus/*metabolism
G Protein-Coupled Inwardly-Rectifying Potassium Channels/*metabolism
Receptor, Serotonin, 5-HT1A/*metabolism
Serotonergic Neurons/*metabolism
Animals ; Barium/pharmacology ; Bee Venoms/pharmacology ; Benzazepines/pharmacology ; Dorsal Raphe Nucleus/drug effects ; Electric Conductivity ; Estrenes/pharmacology ; Male ; Maleates/pharmacology ; Pyrrolidinones/pharmacology ; Rats, Wistar ; Serotonergic Neurons/drug effects

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Skocz do pozycji: 19.

Tytuł:: Establishment of a High-Throughput Assay to Monitor Influenza A Virus RNA Transcription and Replication.
Autorzy:: Wang Z; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Zhao F; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Gao Q; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Liu Z; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Zhang Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Li X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Li Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Ma W; Department of Biochemistry, Guangdong Medical College, Zhanjiang, Guangdong, China.
Deng T; Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.
Zhang Z; Department of Biochemistry, Guangdong Medical College, Zhanjiang, Guangdong, China.
Cen S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Jul 21; Vol. 10 (7), pp. e0133558. Date of Electronic Publication: 2015 Jul 21 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Transcription, Genetic*
Influenza A virus/*genetics
RNA, Viral/*genetics
Cell Line, Tumor ; Cell Survival ; Drug Resistance, Viral/genetics ; Genes, Reporter ; Genome ; Genome, Viral ; HEK293 Cells ; Humans ; Influenza A virus/physiology ; Influenza, Human/virology ; Luciferases/metabolism ; Pyrrolidinones ; RNA, Small Interfering/metabolism ; RNA-Dependent RNA Polymerase/genetics ; Reproducibility of Results ; Virus Replication/drug effects

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Skocz do pozycji: 20.

Tytuł:: Heat Shock Protein 70 Prevents Hyperoxia-Induced Disruption of Lung Endothelial Barrier via Caspase-Dependent and AIF-Dependent Pathways.
Autorzy:: Kondrikov D; Department of Pharmacology & Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, United States of America.
Fulton D; Department of Pharmacology & Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, United States of America; Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, United States of America.
Dong Z; Department of Cell Biology and Anatomy, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, United States of America; Research Service, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia 30912, United States of America.
Su Y; Department of Pharmacology & Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, United States of America; Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, United States of America; Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, United States of America; Research Service, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia 30912, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Jun 11; Vol. 10 (6), pp. e0129343. Date of Electronic Publication: 2015 Jun 11 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Cell Hypoxia*
Apoptosis Inducing Factor/*metabolism
HSP70 Heat-Shock Proteins/*metabolism
Animals ; Apoptosis/drug effects ; Benzhydryl Compounds/pharmacology ; Caspase 3/metabolism ; Cattle ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; HSP70 Heat-Shock Proteins/antagonists & inhibitors ; HSP70 Heat-Shock Proteins/genetics ; Immunoprecipitation ; Pulmonary Artery/cytology ; Pyrrolidinones/pharmacology ; RNA Interference ; RNA, Small Interfering/metabolism ; Reactive Oxygen Species/metabolism

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