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Tytuł :
SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
Autorzy :
Kunii M; Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.; Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
Noguchi Y; Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yoshimura SI; Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kanda S; Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Iwano T; Department of Anatomy and Cell Biology, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.
Avriyanti E; Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.; Department of Dermatology and Venereology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Atik N; Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.; Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Sato T; Laboratory of Developmental Biology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
Sato K; Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
Ogawa M; RIKEN Brain Science Institute, Saitama, Japan.
Harada A; Department of Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.; Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Jan 04; Vol. 220 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Polarity*
Brain/*pathology
Neuroglia/*metabolism
Neuroglia/*pathology
Qb-SNARE Proteins/*deficiency
Qc-SNARE Proteins/*deficiency
Animals ; Apoptosis ; Brain/physiopathology ; COS Cells ; Cadherins/metabolism ; Cell Differentiation ; Cell Membrane/metabolism ; Cell Movement ; Cell Nucleus/metabolism ; Cells, Cultured ; Chlorocebus aethiops ; Down-Regulation ; Gait ; Mice, Knockout ; Neurogenesis ; Neurons/pathology ; Qb-SNARE Proteins/metabolism ; Qc-SNARE Proteins/metabolism ; R-SNARE Proteins ; Receptors, Notch/metabolism ; Signal Transduction ; Syntaxin 1/metabolism ; Transport Vesicles/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Small extracellular vesicles containing miR-30a-3p attenuate the migration and invasion of hepatocellular carcinoma by targeting SNAP23 gene.
Autorzy :
Liu C; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Zhou X; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Long Q; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Zeng H; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Sun Q; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Chen Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Wu D; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China. .
Liu L; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, PR China. .
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Źródło :
Oncogene [Oncogene] 2021 Jan; Vol. 40 (2), pp. 233-245. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carcinoma, Hepatocellular/*pathology
Extracellular Vesicles/*metabolism
MicroRNAs/*genetics
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation ; Extracellular Vesicles/genetics ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Qb-SNARE Proteins/genetics ; Qc-SNARE Proteins/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
Autorzy :
Eubanks HB; Division of Gastroenterology and Hepatology, University of Arkansas for Medical SciencesLittle Rock, ARUSA.
Lavoie EG; Division of Gastroenterology and Hepatology, University of Arkansas for Medical SciencesLittle Rock, ARUSA.
Goree J; Division of Gastroenterology and Hepatology, University of Arkansas for Medical SciencesLittle Rock, ARUSA.
Kamykowski JA; Department of Physiology and Biophysics, University of Arkansas for Medical SciencesLittle Rock, ARUSA.
Gokden N; Department of Pathology, University of Arkansas for Medical SciencesLittle Rock, ARUSA.
Fausther M; Division of Gastroenterology and Hepatology, University of Arkansas for Medical SciencesLittle Rock, ARUSA.
Dranoff JA; Division of Gastroenterology and Hepatology, University of Arkansas for Medical SciencesLittle Rock, ARUSA.
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Źródło :
Gene expression [Gene Expr] 2020 Jun 12; Vol. 20 (1), pp. 25-37. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Actin Cytoskeleton/*ultrastructure
Hepatic Stellate Cells/*ultrastructure
Myofibroblasts/*ultrastructure
Qb-SNARE Proteins/*deficiency
Qc-SNARE Proteins/*deficiency
Actin Cytoskeleton/chemistry ; Actin Depolymerizing Factors/biosynthesis ; Actins/analysis ; Animals ; Carbon Tetrachloride/toxicity ; Cell Line ; Cell Movement ; Cell Separation ; Gene Knockdown Techniques ; Hepatic Stellate Cells/metabolism ; Humans ; Liver/cytology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Mice ; Qb-SNARE Proteins/antagonists & inhibitors ; Qb-SNARE Proteins/genetics ; Qb-SNARE Proteins/physiology ; Qc-SNARE Proteins/antagonists & inhibitors ; Qc-SNARE Proteins/genetics ; Qc-SNARE Proteins/physiology ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacology ; Signal Transduction ; Stress Fibers/chemistry ; Stress Fibers/ultrastructure ; Wound Healing ; rho-Associated Kinases/physiology
Czasopismo naukowe
Tytuł :
Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
Autorzy :
Sokpor G; Institute for Neuroanatomy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany; Institute for Human Genetics, Ruhr University of Bochum, Bochum, Germany.
Rosenbusch J; Institute for Neuroanatomy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Kunwar AJ; Institute for Neuroanatomy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany; Department of Anatomy, Nepalese Army Institute of Health Sciences, College of Medicine, Kathmandu, Nepal; Kathmandu Center for Genomics and Research Laboratory, Kathmandu, Nepal.
Rickmann M; Institute for Neuroanatomy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Tuoc T; Institute for Neuroanatomy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany; Institute for Human Genetics, Ruhr University of Bochum, Bochum, Germany.
Rizzoli SO; Institute of Neuro- and Sensory Physiology, University of Göttingen Medical Centre, Germany.
Tarabykin V; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany; Institute of Neuroscience, Lobachevsky State University of Nizhni Novogorod, 23 Prospekt Gagarina, 603950 Nizhny Novgorod, Russia.
von Mollard GF; Department of Biochemistry III, Bielefeld University, Bielefeld, Germany.
Krieglstein K; Institute for Neuroanatomy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany; Institute for Anatomy and Cell Biology, Department of Molecular Embryology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Staiger JF; Institute for Neuroanatomy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2021 May 21; Vol. 463, pp. 303-316. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neural Stem Cells*/metabolism
Neurons*/metabolism
Animals ; Cell Differentiation ; Cerebral Cortex/metabolism ; Mice ; Neurogenesis ; Qb-SNARE Proteins/metabolism ; SNARE Proteins/metabolism
Czasopismo naukowe
Tytuł :
IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.
Autorzy :
Peng X; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Yang L; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Ma Y; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Li X; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Yang S; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Li Y; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Wu B; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Tang S; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Zhang F; Department of Cell Biology, Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, China Medical University, Shenyang 110122, China.
Zhang B; Funtional Laboratory Center, College of Basic Medicine, China Medical University, Shenyang 110122, China.
Liu J; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Li H; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Jan; Vol. 1868 (1), pp. 118857. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*genetics
I-kappa B Kinase/*genetics
Qb-SNARE Proteins/*genetics
Qc-SNARE Proteins/*genetics
rab GTP-Binding Proteins/*genetics
Autophagosomes/genetics ; Cell Line, Tumor ; Endosomes/genetics ; Exocytosis/genetics ; Extracellular Vesicles/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Lysosomes/genetics ; Membrane Fusion/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; Phosphorylation/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death.
Autorzy :
Chen F; Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Amgalan D; Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Kitsis RN; Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA; Wilf Family Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Pessin JE; Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA; Wilf Family Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA.
Feng D; Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 30; Vol. 295 (44), pp. 15045-15053. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Apoptosis/*physiology
Autophagy/*physiology
Autophagy-Related Proteins/*physiology
bcl-2-Associated X Protein/*metabolism
Animals ; Autophagy-Related Proteins/metabolism ; Mice ; NIH 3T3 Cells ; Protein Binding ; Qb-SNARE Proteins/genetics ; Qb-SNARE Proteins/metabolism ; Qc-SNARE Proteins/genetics ; Qc-SNARE Proteins/metabolism ; Subcellular Fractions/metabolism
Czasopismo naukowe
Tytuł :
SNAP23 is required for constitutive and regulated exocytosis in mouse oocytes†.
Autorzy :
Mehlmann LM; Department of Cell Biology, UConn Health, Farmington, Connecticut, USA.
Uliasz TF; Department of Cell Biology, UConn Health, Farmington, Connecticut, USA.
Lowther KM; Department of Cell Biology, UConn Health, Farmington, Connecticut, USA.
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Źródło :
Biology of reproduction [Biol Reprod] 2019 Aug 01; Vol. 101 (2), pp. 338-346.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Exocytosis/*physiology
Oocytes/*metabolism
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
Animals ; Calcium/metabolism ; Cell Culture Techniques ; Female ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Meiosis/physiology ; Mice ; Oocytes/drug effects ; Ovarian Follicle ; Preservatives, Pharmaceutical ; Qb-SNARE Proteins/genetics ; Qc-SNARE Proteins/genetics ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Synaptosomal-Associated Protein 25/genetics ; Synaptosomal-Associated Protein 25/metabolism ; Thimerosal/pharmacology
Czasopismo naukowe
Tytuł :
Association of VAMP8 rs1010 Polymorphism with Host Susceptibility to Pulmonary Tuberculosis in a Chinese Han Population.
Autorzy :
Cheng S; 1 Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
Sun C; 2 Department of Clinical Laboratory Diagnostics, China Medical University, Shenyang, Liaoning, P.R. China.
Lao W; 2 Department of Clinical Laboratory Diagnostics, China Medical University, Shenyang, Liaoning, P.R. China.; 3 Department of Laboratory Medicine, The Second Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China.
Kang H; 1 Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
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Źródło :
Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2019 May; Vol. 23 (5), pp. 299-303. Date of Electronic Publication: 2019 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
Qb-SNARE Proteins/*genetics
R-SNARE Proteins/*genetics
Tuberculosis, Pulmonary/*genetics
Adult ; Asian Continental Ancestry Group ; Biomarkers/blood ; Case-Control Studies ; China ; Ethnic Groups ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genetic Testing/methods ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Qb-SNARE Proteins/metabolism ; R-SNARE Proteins/metabolism ; Tuberculosis, Pulmonary/metabolism
Czasopismo naukowe
Tytuł :
Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.
Autorzy :
Yang L; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Peng X; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Li Y; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Zhang X; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Ma Y; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Wu C; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Fan Q; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Wei S; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Li H; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China. .
Liu J; Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China. .
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Źródło :
Molecular cancer [Mol Cancer] 2019 Apr 03; Vol. 18 (1), pp. 78. Date of Electronic Publication: 2019 Apr 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Exosomes/*metabolism
Liver Neoplasms/*genetics
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
RNA, Long Noncoding/*genetics
rab GTP-Binding Proteins/*metabolism
Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Movement ; Disease Progression ; Exosomes/genetics ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Liver Neoplasms/metabolism ; Microscopy, Confocal ; Microscopy, Electron, Transmission ; Phosphorylation ; Protein Transport ; Qb-SNARE Proteins/genetics ; Qc-SNARE Proteins/genetics ; Signal Transduction ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Vti1b promotes TRPV1 sensitization during inflammatory pain.
Autorzy :
Sondermann JR; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Barry AM; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Jahn O; Proteomics Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Michel N; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Abdelaziz R; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Kügler S; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.
Gomez-Varela D; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
Schmidt M; Somatosensory Signaling and Systems Biology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany. Ms. Barry is now with Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Ms. Abdelaziz is now with Oncophysiology Group, Max-Planck Institute of Experimental Medicine, Goettingen, Germany.
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Źródło :
Pain [Pain] 2019 Feb; Vol. 160 (2), pp. 508-527.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation/*genetics
Hyperalgesia/*genetics
Pain/*metabolism
Qb-SNARE Proteins/*metabolism
TRPV Cation Channels/*metabolism
Animals ; Calcium/metabolism ; Capsaicin/pharmacology ; Cells, Cultured ; Disease Models, Animal ; Freund's Adjuvant/toxicity ; Ganglia, Spinal/cytology ; Humans ; Hyperalgesia/physiopathology ; Inflammation/chemically induced ; Inflammation/complications ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pain/etiology ; Qb-SNARE Proteins/genetics ; RNA Interference/physiology ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/physiology ; Signal Transduction ; TRPV Cation Channels/genetics
Czasopismo naukowe
Tytuł :
SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy.
Autorzy :
Feng D; Department of Medicine.; Department of Molecular Pharmacology.
Amgalan D; Department of Medicine.; Department of Cell Biology, and.
Singh R; Department of Medicine.; Department of Molecular Pharmacology.; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Wei J; Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, and.
Wen J; Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA.
Wei TP; Department of Medicine.
McGraw TE; Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA.
Kitsis RN; Department of Medicine.; Department of Cell Biology, and.; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.; Wilf Family Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Pessin JE; Department of Medicine.; Department of Molecular Pharmacology.; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.; Wilf Family Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2018 Aug 31; Vol. 128 (9), pp. 3941-3956. Date of Electronic Publication: 2018 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*cytology
Adipocytes/*metabolism
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
bcl-2-Associated X Protein/*metabolism
3T3-L1 Cells ; Animals ; Apoptosis/physiology ; Autophagy/physiology ; Autophagy-Related Protein 7/deficiency ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Autophagy-Related Proteins/deficiency ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Lipodystrophy/metabolism ; Lipodystrophy/pathology ; Male ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Proteolysis ; Qb-SNARE Proteins/deficiency ; Qb-SNARE Proteins/genetics ; Qc-SNARE Proteins/deficiency ; Qc-SNARE Proteins/genetics ; Vesicular Transport Proteins/deficiency ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; bcl-2-Associated X Protein/deficiency ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Platelet-specific deletion of SNAP23 ablates granule secretion, substantially inhibiting arterial and venous thrombosis in mice.
Autorzy :
Williams CM; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Li Y; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Brown E; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Poole AW; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
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Źródło :
Blood advances [Blood Adv] 2018 Dec 26; Vol. 2 (24), pp. 3627-3636.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Platelets/*metabolism
Qb-SNARE Proteins/*genetics
Qc-SNARE Proteins/*genetics
Thrombosis/*pathology
Animals ; Blood Platelets/pathology ; Calcium Signaling/drug effects ; Carrier Proteins/pharmacology ; Cytoplasmic Granules/metabolism ; Female ; Male ; Mice ; Mice, Knockout ; Peptides/pharmacology ; Platelet Activation/drug effects ; Qb-SNARE Proteins/deficiency ; Qc-SNARE Proteins/deficiency ; Thrombopoietin/pharmacology ; Thrombosis/prevention & control ; Venous Thrombosis/pathology ; Venous Thrombosis/prevention & control
Czasopismo naukowe
Tytuł :
O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats.
Autorzy :
Huang L; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Yuan P; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Yu P; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Kong Q; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Xu Z; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Yan X; The Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Shen Y; The Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Yang J; Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Wan R; The Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Hong K; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Tang Y; Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Hu J; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2018 Dec; Vol. 42 (6), pp. 3278-3290. Date of Electronic Publication: 2018 Sep 07.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*physiology
Cardiomyopathies/*metabolism
Diabetes Mellitus, Experimental/*metabolism
Myocytes, Cardiac/*metabolism
Qa-SNARE Proteins/*metabolism
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
R-SNARE Proteins/*metabolism
Animals ; Autophagy/genetics ; Cardiomyopathies/pathology ; Cells, Cultured ; Diabetes Mellitus, Experimental/pathology ; Echocardiography, Doppler ; Immunoprecipitation ; Male ; Microscopy, Electron, Transmission ; Myocytes, Cardiac/pathology ; Qa-SNARE Proteins/genetics ; Qb-SNARE Proteins/genetics ; Qc-SNARE Proteins/genetics ; R-SNARE Proteins/genetics ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
SNAP23 suppresses cervical cancer progression via modulating the cell cycle.
Autorzy :
Zhu B; Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China.
Zhang Q; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China; Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Wu Y; Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China.
Luo J; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China; Department of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Zheng X; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China; Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Xu L; Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China. Electronic address: .
Lu E; Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China. Electronic address: .
Qu J; Department of Gynecologic Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China. Electronic address: .
Ren B; Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China.
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Źródło :
Gene [Gene] 2018 Oct 05; Vol. 673, pp. 217-224. Date of Electronic Publication: 2018 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle*
Cyclin B1/*metabolism
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Qb-SNARE Proteins/*genetics
Qc-SNARE Proteins/*genetics
Uterine Cervical Neoplasms/*genetics
Animals ; Cell Division ; Cell Line, Tumor ; Cell Movement ; Computational Biology ; Disease Progression ; Female ; G2 Phase ; HeLa Cells ; Humans ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Phenotype ; Qb-SNARE Proteins/metabolism ; Qc-SNARE Proteins/metabolism ; RNA, Small Interfering/metabolism ; Up-Regulation ; Uterine Cervical Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
SNAP23-Kif5 complex controls mGlu1 receptor trafficking.
Autorzy :
Raynaud F; IGF, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Homburger V; IGF, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Seveno M; BioCampus Montpellier, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Vigy O; IGF, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Moutin E; IGF, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Fagni L; IGF, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Perroy J; IGF, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
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Źródło :
Journal of molecular cell biology [J Mol Cell Biol] 2018 Oct 01; Vol. 10 (5), pp. 423-436.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Kinesin/*metabolism
Microtubules/*metabolism
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
Receptors, Metabotropic Glutamate/*metabolism
Animals ; Cells, Cultured ; Female ; Hippocampus/cytology ; Kinesin/genetics ; Male ; Mice, Transgenic ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Neurons/metabolism ; Protein Interaction Domains and Motifs ; Protein Transport ; Qb-SNARE Proteins/genetics ; Qc-SNARE Proteins/genetics ; Rats, Wistar ; Receptors, Metabotropic Glutamate/genetics
Czasopismo naukowe
Tytuł :
Turnip Mosaic Virus Uses the SNARE Protein VTI11 in an Unconventional Route for Replication Vesicle Trafficking.
Autorzy :
Cabanillas DG; Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, Québec H7V 1B7, Canada.
Jiang J; Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, Québec H7V 1B7, Canada.
Movahed N; Department of Biology, McGill University, Montréal, Québec H3A 1B1, Canada.
Germain H; Department of Chemistry, Biochemistry, and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec G9A 5H7, Canada.
Yamaji Y; Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 1138657, Japan.
Zheng H; Department of Biology, McGill University, Montréal, Québec H3A 1B1, Canada.
Laliberté JF; Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, Québec H7V 1B7, Canada .
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Źródło :
The Plant cell [Plant Cell] 2018 Oct; Vol. 30 (10), pp. 2594-2615. Date of Electronic Publication: 2018 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arabidopsis/*virology
Arabidopsis Proteins/*metabolism
Host-Pathogen Interactions/*physiology
Potyvirus/*physiology
Qb-SNARE Proteins/*metabolism
Tobacco/*virology
Amino Acid Motifs ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Brefeldin A/pharmacology ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/virology ; Golgi Apparatus/metabolism ; Golgi Apparatus/virology ; Mutagenesis, Site-Directed ; Plant Leaves/virology ; Plants, Genetically Modified ; Potyvirus/pathogenicity ; Qb-SNARE Proteins/genetics ; SNARE Proteins/genetics ; SNARE Proteins/metabolism ; Synaptotagmins/metabolism ; Tobacco/drug effects ; Tobacco/genetics ; Vesicular Transport Proteins/chemistry ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication/physiology
SCR Organism :
Turnip mosaic virus
Czasopismo naukowe
Tytuł :
Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
Autorzy :
Li Y; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Cheng X; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Li M; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Wang Y; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Fu T; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Zhou Z; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Wang Y; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Gong X; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Xu X; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Liu J; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.
Pan L; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China; .; School of Chemistry and Material Sciences, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 310024 Hangzhou, China.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 01; Vol. 117 (35), pp. 21391-21402. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagosomes/*physiology
Lysosomes/*physiology
Qa-SNARE Proteins/*metabolism
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
R-SNARE Proteins/*metabolism
Amino Acid Motifs ; Apoptosis Regulatory Proteins/metabolism ; Autophagy-Related Protein 8 Family/metabolism ; Escherichia coli ; Humans ; Microtubule-Associated Proteins/metabolism
Czasopismo naukowe
Tytuł :
The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2.
Autorzy :
Davidsen J; Department of Science and Environment, Roskilde University, Roskilde, Denmark.; Department of Surgery, Zealand University Hospital, Roskilde, Denmark.
Larsen S; Department of Science and Environment, Roskilde University, Roskilde, Denmark.; Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.
Coskun M; Department of Gastroenterology, Herlev Hospital, Herlev, Denmark.
Gögenur I; Department of Surgery, Zealand University Hospital, Roskilde, Denmark.
Dahlgaard K; Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Bennett EP; Copenhagen Center for Glycomics, Department of Odontology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Troelsen JT; Department of Science and Environment, Roskilde University, Roskilde, Denmark.
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Źródło :
PloS one [PLoS One] 2018 Jul 05; Vol. 13 (7), pp. e0200215. Date of Electronic Publication: 2018 Jul 05 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Wnt Signaling Pathway*
CDX2 Transcription Factor/*genetics
Colonic Neoplasms/*genetics
Oncogene Proteins, Fusion/*genetics
Qb-SNARE Proteins/*genetics
Transcription Factor 7-Like 2 Protein/*genetics
Binding Sites ; CDX2 Transcription Factor/metabolism ; Cell Line, Tumor ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Genes, Reporter ; Humans ; Intestines/pathology ; Oncogene Proteins, Fusion/metabolism ; Promoter Regions, Genetic ; Qb-SNARE Proteins/metabolism ; Transcription Factor 7-Like 2 Protein/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.
Autorzy :
Dodson M; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Liu P; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Jiang T; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Ambrose AJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Luo G; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Rojo de la Vega M; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Cholanians AB; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Wong PK; Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Chapman E; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Zhang DD; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA .; Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2018 May 15; Vol. 38 (11). Date of Electronic Publication: 2018 May 15 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Arsenic/*pharmacology
Autophagy/*drug effects
Lysosomes/*metabolism
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
Animals ; HeLa Cells ; Humans ; Membrane Fusion/physiology ; Mice ; NIH 3T3 Cells ; Phagosomes/metabolism ; Protein Binding ; Qb-SNARE Proteins/genetics ; Qc-SNARE Proteins/genetics
Czasopismo naukowe
Tytuł :
Dynamic cycling of t-SNARE acylation regulates platelet exocytosis.
Autorzy :
Zhang J; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Huang Y; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Chen J; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Zhu H; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536.
Whiteheart SW; From the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Mar 09; Vol. 293 (10), pp. 3593-3606. Date of Electronic Publication: 2018 Jan 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Exocytosis*/drug effects
Protein Processing, Post-Translational*/drug effects
Blood Platelets/*metabolism
Cysteine/*metabolism
Qa-SNARE Proteins/*metabolism
Qb-SNARE Proteins/*metabolism
Qc-SNARE Proteins/*metabolism
Acylation/drug effects ; Acyltransferases/antagonists & inhibitors ; Acyltransferases/metabolism ; Blood Platelets/drug effects ; Blood Platelets/enzymology ; Cysteine/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Hydroxylamine/pharmacology ; Membrane Microdomains/drug effects ; Membrane Microdomains/metabolism ; Oxidation-Reduction ; P-Selectin/metabolism ; Palmitic Acid/metabolism ; Platelet Activation/drug effects ; Platelet Aggregation/drug effects ; Protein Transport/drug effects ; Qa-SNARE Proteins/chemistry ; Qb-SNARE Proteins/chemistry ; Qc-SNARE Proteins/chemistry ; Reducing Agents/pharmacology ; Surface Properties/drug effects ; Thiolester Hydrolases/antagonists & inhibitors ; Thiolester Hydrolases/metabolism ; Tritium
Czasopismo naukowe

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