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Tytuł :
Genomic Alterations in PIK3CA -Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors.
Autorzy :
Cai Y; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York. .
Xu G; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.; National Institute of Biological Sciences (NIBS), Beijing, China.
Wu F; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.
Michelini F; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Chan C; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.
Qu X; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.
Selenica P; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ladewig E; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Castel P; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.
Cheng Y; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Zhao A; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.
Jhaveri K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Toska E; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.
Jimenez M; Unicancer, Paris, France.
Jacquet A; Unicancer, Paris, France.
Tran-Dien A; INSERM UMR981 and Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris Saclay, Le Kremlin-Bicetre, France.
Andre F; INSERM UMR981 and Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris Saclay, Le Kremlin-Bicetre, France.; Department of Medical Oncology, Gustave Roussy, Université Paris Saclay, Villejuif, France.
Chandarlapaty S; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Reis-Filho JS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Razavi P; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Scaltriti M; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, New York. .; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
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Źródło :
Cancer research [Cancer Res] 2021 May 01; Vol. 81 (9), pp. 2470-2480. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.
Autorzy :
Kim JK; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Marco MR; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Choi SH; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Qu X; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, USA.
Chen CT; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Elkabets M; Shraga Segal Department of Microbiology, Immunology and Genetics, University of the Negev, Beer-Sheva, Israel.
Fairchild L; Department of Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, USA.
Chow O; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Barriga FM; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, USA.
Dow LE; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Medicine, Weill-Cornell Medical College, New York, USA.
O'Rourke K; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Medicine, Weill-Cornell Medical College, New York, USA.
Szeglin B; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Yarilin D; Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, USA.
Fujisawa S; Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, USA.
Manova-Todorova K; Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, USA.
Paty PB; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Shia J; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
Leslie C; Department of Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, USA.
Smith JJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Lowe S; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, USA.
Pelossof R; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, USA.
Sanchez-Vega F; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, USA.
Garcia-Aguilar J; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
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Źródło :
Molecular oncology [Mol Oncol] 2021 Apr 04. Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Long, Noncoding RNA Dysregulation in Glioblastoma.
Autorzy :
DeSouza PA; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Qu X; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Chen H; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Department of Neuroscience, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Patel B; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Maher CA; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Kim AH; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
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Źródło :
Cancers [Cancers (Basel)] 2021 Mar 31; Vol. 13 (7). Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
[Effects of Palliative Care Consultation on Medicals in Peking Union Medical College Hospital].
Autorzy :
Zhang Y; School of Nursing,CAMS and PUMC,Beijing 100144,China.
Liu Q; Department of International Medical Services,CAMS and PUMC,Beijing 100730,China.
Dai XY; Department of International Medical Services,CAMS and PUMC,Beijing 100730,China.
Zhao XX; Department of International Medical Services,CAMS and PUMC,Beijing 100730,China.
Ge N; Department of Geriatric,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
Qu X; Department of Geriatric,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
Ning XH; Department of Geriatric,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
Zou H; School of Nursing,CAMS and PUMC,Beijing 100144,China.
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Źródło :
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2021 Feb 28; Vol. 43 (1), pp. 9-14.
Typ publikacji :
Journal Article
MeSH Terms :
Palliative Care*
Referral and Consultation*
Hospitals ; Humans ; Qualitative Research
Czasopismo naukowe
Tytuł :
Alterations in intestinal microbiota diversity, composition, and function in patients with sarcopenia.
Autorzy :
Kang L; Department of Geriatrics, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. .
Li P; Allwegene Technology Inc., Beijing, 102209, China.
Wang D; Department of Geriatrics, Urumqi Friendship Hospital, Urumqi, China.
Wang T; Department of Geriatrics Centre, Hainan General Hospital, Haikou, China.
Hao D; Department of Geriatrics, Liaocheng People's Hospital, Liaocheng, Shandong Province, China.
Qu X; Department of Geriatrics, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
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Źródło :
Scientific reports [Sci Rep] 2021 Feb 25; Vol. 11 (1), pp. 4628. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
NDRG2 ablation reprograms metastatic cancer cells towards glutamine dependence via the induction of ASCT2.
Autorzy :
Ding M; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.; State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, No. 145 Changle Xi Road, Xi'an, 710032, China.
Bu X; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.
Li Z; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jiamusi University, Jiamusi, 154002, China.
Xu H; State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, the Fourth Military Medical University, Xi'an 710032, China.
Feng L; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Hu J; Department of Gastroenterology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Wei X; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jiamusi University, Jiamusi, 154002, China.
Gao J; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Tao Y; Xi'an Peihua University, Xi'an, 710125, China.
Cai B; State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, No. 145 Changle Xi Road, Xi'an, 710032, China.
Liu Y; State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, No. 145 Changle Xi Road, Xi'an, 710032, China.
Qu X; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Shen L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.
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Źródło :
International journal of biological sciences [Int J Biol Sci] 2020 Oct 16; Vol. 16 (16), pp. 3100-3115. Date of Electronic Publication: 2020 Oct 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults.
Autorzy :
Levy M; Research and Development Department, USANA Health Science, Inc., Salt Lake City, UT, 84121, USA.
Wu JR; Elegant and Olive Health Clinic, Markham, ON, L3R 5V6, Canada.
Shi JP; Elegant and Olive Health Clinic, Markham, ON, L3R 5V6, Canada.
Cheng HJ; Research and Development Department, USANA Health Science, Inc., Salt Lake City, UT, 84121, USA.
Qu XQ; Elegant and Olive Health Clinic, Markham, ON, L3R 5V6, Canada.
Bernstein I; Department of Family and Community Medicine, Humber River Hospital, Toronto, ON, M1V 2W7, Canada.
Sinnott R; Research and Development Department, USANA Health Science, Inc., Salt Lake City, UT, 84121, USA.
Tian JQ; Research and Development Department, USANA Health Science, Inc., Salt Lake City, UT, 84121, USA. .
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Źródło :
Chinese journal of integrative medicine [Chin J Integr Med] 2020 Aug 19. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells.
Autorzy :
Kalchiem-Dekel O; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Yao X; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Barochia AV; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Kaler M; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Figueroa DM; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Karkowsky WB; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Gordon EM; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Gao M; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Fergusson MM; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Qu X; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
Liu P; DNA Sequencing and Genomics Core Facility, and.
Li Y; DNA Sequencing and Genomics Core Facility, and.
Seifuddin F; Bioinformatics and Computational Core Facility, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Pirooznia M; Bioinformatics and Computational Core Facility, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Levine SJ; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch.
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2020 Aug; Vol. 63 (2), pp. 185-197.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Apolipoproteins E/*metabolism
Asthma/*metabolism
Chemokine CXCL5/*metabolism
Epithelial Cells/*metabolism
Respiratory System/*metabolism
Signal Transduction/*physiology
Toll-Like Receptor 4/*metabolism
Chemokines/metabolism ; Humans ; Inflammation/metabolism ; Neutrophils/metabolism ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Factors associated with health-related quality of life in community-dwelling elderly people in China.
Autorzy :
Wang Q; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Liu X; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhu M; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Pang H; Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; Central Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Kang L; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zeng P; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Ge N; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Qu X; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Chen W; Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Hong X; Department of Psychology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
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Źródło :
Geriatrics & gerontology international [Geriatr Gerontol Int] 2020 May; Vol. 20 (5), pp. 422-429. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Geriatric Assessment*
Quality of Life*
Activities of Daily Living ; Aged ; Aged, 80 and over ; China ; Chronic Disease/epidemiology ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Independent Living ; Male ; Nutritional Status ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
BRAF dictates cell survival via c-Myc-dependent induction of Skp2 in human melanoma.
Autorzy :
Feng L; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Li J; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Bu X; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.
Zuo Y; Affiliated Hospital of Xizang Minzu University, Xianyang, 712082, China.
Shen L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
Qu X; Shaanxi University of Chinese Medicine, Xianyang, 712046, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Mar 26; Vol. 524 (1), pp. 28-35. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Melanoma/*metabolism
Protein Kinase Inhibitors/*chemistry
Proto-Oncogene Proteins B-raf/*antagonists & inhibitors
Proto-Oncogene Proteins c-myc/*metabolism
S-Phase Kinase-Associated Proteins/*metabolism
Vemurafenib/*chemistry
Cell Line, Tumor ; Cell Proliferation ; Cell Survival/genetics ; Drug Resistance, Neoplasm/drug effects ; Gene Expression Regulation, Neoplastic ; Humans ; Mutation ; Protein Kinase Inhibitors/metabolism ; Proto-Oncogene Proteins B-raf/genetics ; RNA, Small Interfering/metabolism ; Vemurafenib/metabolism
Czasopismo naukowe
Tytuł :
ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer.
Autorzy :
Xu G; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chhangawala S; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Physiology, Biophysics, and Systems Biology Program, Weill Cornell Graduate School, New York, NY, USA.
Cocco E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Razavi P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cai Y; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Otto JE; Depatment of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Ferrando L; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Internal Medicine, Università degli Studi di Genova, Genova, Italy.
Selenica P; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ladewig E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chan C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Da Cruz Paula A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Witkin M; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cheng Y; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Park J; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Serna-Tamayo C; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhao H; Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wu F; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sallaku M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Qu X; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zhao A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Collings CK; Depatment of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
D'Avino AR; Depatment of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Jhaveri K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Koche R; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Reis-Filho JS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kadoch C; Depatment of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Scaltriti M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .
Baselga J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Research & Development Oncology, AstraZeneca Pharmaceuticals, Gaithersburg, MD, USA. .
Toska E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .
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Źródło :
Nature genetics [Nat Genet] 2020 Feb; Vol. 52 (2), pp. 198-207. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
DNA-Binding Proteins/*genetics
Drug Resistance, Neoplasm/*genetics
Receptors, Estrogen/*metabolism
Transcription Factors/*genetics
Animals ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Case-Control Studies ; Cell Line, Tumor ; Chromatin/genetics ; Chromatin/metabolism ; DNA-Binding Proteins/metabolism ; Female ; GATA3 Transcription Factor/genetics ; GATA3 Transcription Factor/metabolism ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Humans ; Mice ; Mutation ; Receptors, Estrogen/genetics ; Transcription Factors/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review).
Autorzy :
Li M; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
Bu X; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
Cai B; State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
Liang P; The State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
Li K; Department of Clinical Laboratory, General Hospital of Xinjiang Military Command, Xinjiang 830000, P.R. China.
Qu X; School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China.
Shen L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2019 Feb; Vol. 41 (2), pp. 727-741. Date of Electronic Publication: 2018 Nov 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Biomarkers, Tumor/*metabolism
Epithelial-Mesenchymal Transition/*drug effects
Metabolic Networks and Pathways/*drug effects
Neoplasms/*drug therapy
Amino Acids/metabolism ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/antagonists & inhibitors ; Disease Progression ; Energy Metabolism/drug effects ; Glucose/metabolism ; Glycolysis/drug effects ; Humans ; Lipid Metabolism/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Nucleic Acids/metabolism
Czasopismo naukowe
Tytuł :
Physicians' Perception of Palliative Care Consultation Service in a Major General Hospital in China.
Autorzy :
Qu X; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Jiang N; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Ge N; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Ning XH; Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
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Źródło :
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih [Chin Med Sci J] 2018 Dec 30; Vol. 33 (4), pp. 228-233.
Typ publikacji :
Journal Article
MeSH Terms :
Palliative Care/*organization & administration
Physicians/*psychology
China ; Hospitals, General ; Humans ; Referral and Consultation ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
c-Myc-driven glycolysis via TXNIP suppression is dependent on glutaminase-MondoA axis in prostate cancer.
Autorzy :
Qu X; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Sun J; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Zhang Y; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Li J; Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Hu J; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Li K; Department of Clinical Laboratory, General Hospital of Xinjiang Military Command, 830000, China.
Gao L; Department of Urology, Wuhan General Hospital of Guangzhou Military Region, Wuhan, Hubei, 430070, China. Electronic address: .
Shen L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Oct 02; Vol. 504 (2), pp. 415-421. Date of Electronic Publication: 2018 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycolysis*
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Carrier Proteins/*metabolism
Glutaminase/*metabolism
Prostatic Neoplasms/*metabolism
Proto-Oncogene Proteins c-myc/*metabolism
Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Ketoglutaric Acids/metabolism ; Male ; Phenotype ; Principal Component Analysis ; Prostatic Hyperplasia/metabolism
Czasopismo naukowe
Tytuł :
Low-density lipoprotein receptor-related protein 1 attenuates house dust mite-induced eosinophilic airway inflammation by suppressing dendritic cell-mediated adaptive immune responses.
Autorzy :
Mishra A; Laboratory of Asthma and Lung Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Yao X; Laboratory of Asthma and Lung Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Saxena A; Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Gordon EM; Laboratory of Asthma and Lung Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Kaler M; Laboratory of Asthma and Lung Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Cuento RA; Laboratory of Asthma and Lung Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Barochia AV; Laboratory of Asthma and Lung Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Dagur PK; Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
McCoy JP; Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Keeran KJ; Animal Surgery and Resources Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Jeffries KR; Animal Surgery and Resources Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Qu X; Pathology Core Facility, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Yu ZX; Pathology Core Facility, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Levine SJ; Laboratory of Asthma and Lung Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2018 Oct; Vol. 142 (4), pp. 1066-1079.e6. Date of Electronic Publication: 2017 Dec 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Asthma/*immunology
Dendritic Cells/*immunology
Dermatophagoides pteronyssinus/*immunology
Eosinophilia/*immunology
Low Density Lipoprotein Receptor-Related Protein-1/*immunology
Adaptive Immunity ; Adult ; Allergens/immunology ; Animals ; Antigens, Dermatophagoides/immunology ; Asthma/blood ; Asthma/physiopathology ; Bronchoalveolar Lavage Fluid/cytology ; Eosinophilia/blood ; Eosinophilia/physiopathology ; Female ; Humans ; Immunoglobulin E/blood ; Immunoglobulin G/blood ; Male ; Mice, Transgenic ; Middle Aged
Czasopismo naukowe
Tytuł :
[Needs of Continuing Education on Hospice and Palliative Care in China:A Questionnaire-based Survey].
Autorzy :
Ge N; Department of Geriatric,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Qu X; Department of Geriatric,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Ning XH; Department of Geriatric,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Liu XH; Department of Geriatric,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
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Źródło :
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2018 Jun 28; Vol. 40 (3), pp. 390-394.
Typ publikacji :
Journal Article
MeSH Terms :
Education, Medical, Continuing*
Education, Nursing, Continuing*
Hospices*
Palliative Care*
China ; Humans ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis.
Autorzy :
Shen L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China. .
Qu X; Shaanxi University of Chinese Medicine, Xianyang, China.
Li H; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Xu C; Department of General Surgery, No.537 Hospital of PLA, Baoji, China.
Wei M; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Wang Q; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Ru Y; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Liu B; Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Xu Y; The State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Li K; Department of Clinical Laboratory, General Hospital of Xinjiang Military Command, Xinjiang, China.
Hu J; Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wang L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Ma Y; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Li M; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Lai X; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Gao L; Department of Urology, Wuhan General Hospital of Guangzhou Military Region, Wuhan, Hubei, China.
Wu K; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
Yao L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Zheng J; State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China. .
Zhang J; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China. .
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Źródło :
Oncogene [Oncogene] 2018 Mar; Vol. 37 (13), pp. 1759-1774. Date of Electronic Publication: 2018 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*pathology
Cell Differentiation/*genetics
Colorectal Neoplasms/*pathology
S-Phase Kinase-Associated Proteins/*genetics
Tumor Suppressor Proteins/*physiology
Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Animals ; Biomarkers, Tumor/physiology ; Caco-2 Cells ; Cell Proliferation/genetics ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; HT29 Cells ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Nude ; S-Phase Kinase-Associated Proteins/metabolism ; Signal Transduction/genetics ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Tg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation.
Autorzy :
Huang Q; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Pu M; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Zhao G; Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Dai B; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Bian Z; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Tang H; Department of Thyroid, Breast and Vascular Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China.
Chen C; Department of Neurosurgery, 451 Hospital of PLA, Xi'an 710055, Shaanxi Province, China.
Liu W; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Qu X; Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
Shen L; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China. Electronic address: .
Tao K; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2017 Aug 28; Vol. 402, pp. 52-60. Date of Electronic Publication: 2017 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition*
Carcinoma, Hepatocellular/*metabolism
Cell Transformation, Neoplastic/*metabolism
Hepatocyte Nuclear Factor 4/*metabolism
Liver/*metabolism
Liver Neoplasms/*metabolism
Neoplastic Stem Cells/*metabolism
Snail Family Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
Animals ; Apoptosis ; Carcinoma, Hepatocellular/chemically induced ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line ; Cell Proliferation ; Cell Transformation, Neoplastic/chemically induced ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Diethylnitrosamine ; Feedback, Physiological ; Gene Expression Regulation, Neoplastic ; Hepatocyte Nuclear Factor 4/genetics ; Liver/pathology ; Liver Neoplasms/chemically induced ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Mice, Inbred BALB C ; Neoplastic Stem Cells/pathology ; Phenotype ; RNA Interference ; Rats, Inbred F344 ; Snail Family Transcription Factors/genetics ; Time Factors ; Transfection ; Tumor Suppressor Proteins/genetics ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches.
Autorzy :
Dickinson PS; Biology and Neuroscience, Bowdoin College, 6500 College Station, Brunswick, ME 04011, USA. Electronic address: .
Qu X; Neuroscience, Bowdoin College, 6500 College Station, Brunswick, ME 04011, USA.
Stanhope ME; Neuroscience, Bowdoin College, 6500 College Station, Brunswick, ME 04011, USA.
Pokaż więcej
Źródło :
Current opinion in neurobiology [Curr Opin Neurobiol] 2016 Dec; Vol. 41, pp. 149-157. Date of Electronic Publication: 2016 Sep 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Crustacea/*physiology
Neuropeptides/*physiology
Animals ; Biological Evolution
Czasopismo naukowe
Tytuł :
Hollow Porous VO x /C Nanoscrolls as High-Performance Anodes for Lithium-Ion Batteries.
Autorzy :
Jia BR; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Qin ML; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Zhang ZL; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Li SM; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Zhang DY; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Wu HY; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Zhang L; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Lu X; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Qu XH; Institute for Advanced Materials and Technology, University of Science and Technology Beijing , 30 Xueyuan Road, Haidian District, 100083, Beijing, P. R. China.
Pokaż więcej
Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2016 Oct 05; Vol. 8 (39), pp. 25954-25961. Date of Electronic Publication: 2016 Sep 20.
Typ publikacji :
Journal Article
Czasopismo naukowe

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