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Wyszukujesz frazę ""Quinazolines"" wg kryterium: Temat


Tytuł :
The quinazoline derivative, 04NB-03, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells in a reactive oxygen species-dependent manner.
Autorzy :
Wang R; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Zhu Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Chen J; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Wang Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Song X; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Wu Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Jin F; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, China. Electronic address: .
Wang Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, 510632, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Apr 01; Vol. 338, pp. 109371. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*pathology
Cell Cycle Checkpoints/*drug effects
Liver Neoplasms/*pathology
Quinazolines/*pharmacology
Reactive Oxygen Species/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Inhibitory Concentration 50 ; M Phase Cell Cycle Checkpoints/drug effects ; Mice, Inbred BALB C ; Mice, Nude ; Quinazolines/chemistry
Czasopismo naukowe
Tytuł :
In-silico driven design and development of spirobenzimidazo-quinazolines as potential DNA gyrase inhibitors.
Autorzy :
Korrapati SB; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
Yedla P; Division of Applied Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 085, India.
Pillai GG; Discovery Chemistry, Nyro Research India, Kochi, Kerala, 682 021, India.
Mohammad F; Surfactants Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. Electronic address: .
Ch VRR; Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500 085, India.
Bhamidipati P; School of Chemistry, University of Hyderabad, 500 046, India.
Amanchy R; Division of Applied Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 085, India. Electronic address: .
Syed R; Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500 085, India. Electronic address: .
Kamal A; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India; School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, 110 062, India. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Feb; Vol. 134, pp. 111132. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Computer-Aided Design*
Drug Design*
Anti-Bacterial Agents/*pharmacology
Bacteria/*drug effects
Benzimidazoles/*pharmacology
DNA Gyrase/*metabolism
Quinazolines/*pharmacology
Topoisomerase II Inhibitors/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Bacteria/growth & development ; Benzimidazoles/chemical synthesis ; Binding Sites ; Biofilms/drug effects ; Biofilms/growth & development ; DNA Gyrase/chemistry ; Green Chemistry Technology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Quantitative Structure-Activity Relationship ; Quinazolines/chemical synthesis ; Topoisomerase II Inhibitors/chemical synthesis
Czasopismo naukowe
Tytuł :
Cost-effectiveness analysis of fruquintinib versus regorafenib as the third-line therapy for metastatic colorectal cancer in China.
Autorzy :
Guan X; School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.; Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, China.
Li H; School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.; Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, China.
Xiong X; School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.; Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, China.
Peng C; Eli Lilly China Drug Development and Medical Affairs Center, Shanghai, China.
Wang N; Eli Lilly China Drug Development and Medical Affairs Center, Shanghai, China.
Ma X; Eli Lilly China Drug Development and Medical Affairs Center, Shanghai, China.
Ma A; School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.; Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, China.
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Źródło :
Journal of medical economics [J Med Econ] 2021 Jan-Dec; Vol. 24 (1), pp. 339-344.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*economics
Benzofurans/*economics
Benzofurans/*therapeutic use
Colorectal Neoplasms/*drug therapy
Phenylurea Compounds/*economics
Phenylurea Compounds/*therapeutic use
Pyridines/*economics
Pyridines/*therapeutic use
Quinazolines/*economics
Quinazolines/*therapeutic use
Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Benzofurans/adverse effects ; China ; Colorectal Neoplasms/pathology ; Cost-Benefit Analysis ; Health Expenditures/statistics & numerical data ; Health Resources/economics ; Health Resources/statistics & numerical data ; Humans ; Markov Chains ; Models, Economic ; Neoplasm Metastasis ; Phenylurea Compounds/adverse effects ; Pyridines/adverse effects ; Quality-Adjusted Life Years ; Quinazolines/adverse effects
Czasopismo naukowe
Tytuł :
Discovery of 5-methyl- N -(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors.
Autorzy :
Im D; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
Moon H; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
Kim J; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
Oh Y; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
Jang M; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
Hah JM; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1110-1115.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Isoxazoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Quinazolines/*pharmacology
fms-Like Tyrosine Kinase 3/*antagonists & inhibitors
Dose-Response Relationship, Drug ; Humans ; Isoxazoles/chemical synthesis ; Isoxazoles/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinazolines/chemical synthesis ; Quinazolines/chemistry ; Structure-Activity Relationship ; fms-Like Tyrosine Kinase 3/metabolism
Czasopismo naukowe
Tytuł :
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools.
Autorzy :
Sebastian-Perez V; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.
García-Rubia A; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.
Seif El-Din SH; Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Sabra AA; Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
El-Lakkany NM; Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
William S; Parasitology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Blundell TL; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Maes L; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
Martinez A; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.
Campillo NE; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.
Botros SS; Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Gil C; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 511-523.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehyde Reductase/*antagonists & inhibitors
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Quinazolines/*chemistry
Quinazolines/*pharmacology
Schistosoma mansoni/*drug effects
Aldehyde Reductase/metabolism ; Animals ; Anthelmintics ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Male ; Mice ; Models, Molecular ; Molecular Structure ; Quinazolines/chemical synthesis ; Schistosoma mansoni/enzymology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors.
Autorzy :
El-Azab AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abdel-Aziz AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ahmed HEA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo, Egypt.; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.
Bua S; Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
Nocentini A; Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
AlSaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Hefnawy MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Supuran CT; Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 598-609.
Typ publikacji :
Journal Article
MeSH Terms :
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Quinazolines/*pharmacology
Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Quinazolines/chemical synthesis ; Quinazolines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers.
Autorzy :
Gao C; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong AgriculturalUniversity, Wuhan, 430070, China.; College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Liu Z; National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Hou H; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, China.
Ding J; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, China.
Chen X; College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Xie C; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, China.
Song Z; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, China.
Hu Z; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Feng M; College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Mohamed HI; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Chemistry Department, Faculty of Science, Benha University, Benha 13518, Egypt.
Xu S; Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, China.
Parkinson GN; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Haider S; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Wei D; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong AgriculturalUniversity, Wuhan, 430070, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 18; Vol. 48 (20), pp. 11259-11269.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G-Quadruplexes*
Nucleic Acid Conformation*
Cell Proliferation/*drug effects
Quinazolines/*chemistry
Quinazolines/*pharmacology
Telomere/*chemistry
Telomere/*metabolism
Animals ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Circular Dichroism ; DNA Damage ; Fluorescence Resonance Energy Transfer ; Humans ; Inhibitory Concentration 50 ; Ligands ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms/drug therapy ; Quinazolines/therapeutic use ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis.
Autorzy :
El-Azab AS; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: .
Abdel-Aziz AA; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
AlSaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
Eskandrani RO; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
Alharbi A; Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104345. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Quinazolines/*pharmacology
Sulfonamides/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Quinazolines/chemical synthesis ; Quinazolines/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors.
Autorzy :
Elsocht M; Research Group of Organic Chemistry, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Giron P; Laboratory of Medical and Molecular Oncology and Center of Medical Genetics, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.; Laboratory of Pathophysiological Cell Signalling (PACS), Department of Biology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Maes L; VIB-VUB Center for Structural Biology, Pleinlaan 2, 1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Versées W; VIB-VUB Center for Structural Biology, Pleinlaan 2, 1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Gutierrez GJ; Laboratory of Pathophysiological Cell Signalling (PACS), Department of Biology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
De Grève J; Laboratory of Medical and Molecular Oncology and Center of Medical Genetics, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Ballet S; Research Group of Organic Chemistry, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 10; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Benzylamines/*pharmacology
Carcinoma, Non-Small-Cell Lung/*enzymology
Lung Neoplasms/*enzymology
NIMA-Related Kinases/*antagonists & inhibitors
Quinazolines/*pharmacology
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Benzylamines/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Molecular Targeted Therapy ; Mutation ; Neoplasm Proteins/antagonists & inhibitors ; Quinazolines/therapeutic use ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System.
Autorzy :
Skubalova Z; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Rex S; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Sukupova M; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.
Zahalka M; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.
Skladal P; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Pribyl J; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Michalkova H; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Weerasekera A; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Adam V; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Heger Z; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Jan 06; Vol. 16, pp. 1-14. Date of Electronic Publication: 2021 Jan 06 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Ferritins/*chemistry
Folic Acid/*chemistry
Phenylurea Compounds/*pharmacology
Piperidines/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Quinazolines/*pharmacology
Quinolines/*pharmacology
Animals ; Antineoplastic Agents/pharmacology ; Biocompatible Materials/chemistry ; Cell Death/drug effects ; Cell Line ; Cell Movement/drug effects ; Clone Cells ; Diffusion ; Drug Carriers/chemistry ; Horses ; Humans ; Hydrogen-Ion Concentration ; Phenylurea Compounds/chemistry ; Piperidines/chemistry ; Quinazolines/chemistry ; Quinolines/chemistry ; Surface Properties
Czasopismo naukowe
Tytuł :
Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers.
Autorzy :
Amin NH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: .
Elsaadi MT; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Sinai University-Kantra Branch, Egypt.
Zaki SS; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Abdel-Rahman HM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104358. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
ErbB Receptors/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemical synthesis
Quinazolines/*chemical synthesis
A549 Cells ; Aniline Compounds/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/pharmacology ; Quinazolines/pharmacology ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Modelling the structural and reactivity landscapes of tucatinib with special reference to its wavefunction-dependent properties and screening for potential antiviral activity.
Autorzy :
Alsalme A; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Pooventhiran T; Department of Chemistry, St. Berchmans College (Autonomous), Changanassery, Kerala, India.
Al-Zaqri N; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Rao DJ; Department of Physics, Dr. Lankapalli Bullayya College, Visakhapatnam, Andhra Pradesh, India.
Rao SS; Department of Physics, Mrs. A.V.N.College, Visakhapatnam, Andhra Pradesh, India.
Thomas R; Department of Chemistry, St. Berchmans College (Autonomous), Changanassery, Kerala, India. .
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Źródło :
Journal of molecular modeling [J Mol Model] 2020 Nov 16; Vol. 26 (12), pp. 341. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Electrons*
Antineoplastic Agents/*chemistry
Antiviral Agents/*chemistry
Betacoronavirus/*chemistry
Oxazoles/*chemistry
Protease Inhibitors/*chemistry
Pyridines/*chemistry
Quinazolines/*chemistry
Viral Nonstructural Proteins/*antagonists & inhibitors
Antineoplastic Agents/metabolism ; Antiviral Agents/metabolism ; Betacoronavirus/enzymology ; Binding Sites ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/metabolism ; Drug Repositioning ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Oxazoles/metabolism ; Protease Inhibitors/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Pyridines/metabolism ; Quantum Theory ; Quinazolines/metabolism ; SARS-CoV-2 ; Thermodynamics ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Evodiamine: A review of its pharmacology, toxicity, pharmacokinetics and preparation researches.
Autorzy :
Sun Q; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.
Xie L; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.
Song J; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.
Li X; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Nov 15; Vol. 262, pp. 113164. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Drugs, Chinese Herbal/*therapeutic use
Ethnopharmacology/*methods
Medicine, Chinese Traditional/*methods
Quinazolines/*therapeutic use
Analgesics/isolation & purification ; Analgesics/therapeutic use ; Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/therapeutic use ; Drugs, Chinese Herbal/isolation & purification ; Ethnopharmacology/trends ; Humans ; Medicine, Chinese Traditional/trends ; Quinazolines/isolation & purification
Czasopismo naukowe
Tytuł :
Combination of Fruquintinib and Anti-PD-1 for the Treatment of Colorectal Cancer.
Autorzy :
Wang Y; Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.; Department of Oncology, Cancer Rehabilitation Center, Jiangsu Province Hospital, Nanjing 210029, China.
Wei B; Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.; Department of Oncology, Cancer Rehabilitation Center, Jiangsu Province Hospital, Nanjing 210029, China.; The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an 223001, China; and.
Gao J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Cai X; Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.; Department of Oncology, Cancer Rehabilitation Center, Jiangsu Province Hospital, Nanjing 210029, China.
Xu L; Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.; Department of Oncology, Cancer Rehabilitation Center, Jiangsu Province Hospital, Nanjing 210029, China.
Zhong H; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Wang B; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Sun Y; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Guo W; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China .
Xu Q; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China .
Gu Y; Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China; .; Department of Oncology, Cancer Rehabilitation Center, Jiangsu Province Hospital, Nanjing 210029, China.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Nov 15; Vol. 205 (10), pp. 2905-2915. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Benzofurans/*pharmacology
Colorectal Neoplasms/*therapy
Quinazolines/*pharmacology
Tumor Microenvironment/*drug effects
Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzofurans/therapeutic use ; CD8 Antigens/genetics ; Cell Line, Tumor/transplantation ; Chemotherapy, Adjuvant/methods ; Colectomy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/immunology ; Disease Models, Animal ; Drug Synergism ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Mice ; Mice, Knockout ; Microsatellite Instability ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Quinazolines/therapeutic use ; Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Treatment Outcome ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors.
Autorzy :
Lee JY; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Shin YS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Lee J; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Kwon S; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea; Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.
Jin YH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea; KM Application Center, Korea Institute of Oriental Medicine, Dong-gu, Daegu 41062, South Korea.
Jang MS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea; Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.
Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Song JH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kim HR; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Park CM; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Oct 15; Vol. 30 (20), pp. 127472. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds/*pharmacology
Antiviral Agents/*pharmacology
Middle East Respiratory Syndrome Coronavirus/*drug effects
Quinazolines/*pharmacology
Aniline Compounds/chemical synthesis ; Aniline Compounds/pharmacokinetics ; Aniline Compounds/toxicity ; Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/toxicity ; Cell Line ; Chlorocebus aethiops ; Cricetulus ; Humans ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; Quinazolines/chemical synthesis ; Quinazolines/pharmacokinetics ; Quinazolines/toxicity ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.
Autorzy :
Zhang T; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China.; Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, North Carolina 27599-7260, United States.
Lai Z; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China.; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Yuan S; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China.
Huang YY; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China.
Dong G; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Sheng C; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Ke H; Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, North Carolina 27599-7260, United States.
Luo HB; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China.; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Sep 10; Vol. 63 (17), pp. 9828-9837. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclic Nucleotide Phosphodiesterases, Type 5/*metabolism
Phosphodiesterase 5 Inhibitors/*metabolism
Quinazolines/*metabolism
Allosteric Site ; Amino Acid Sequence ; Animals ; Cyclic Nucleotide Phosphodiesterases, Type 5/chemistry ; Drug Discovery ; Male ; Mice ; Molecular Docking Simulation ; Phosphodiesterase 5 Inhibitors/chemistry ; Phosphodiesterase 5 Inhibitors/pharmacokinetics ; Protein Binding ; Quinazolines/chemistry ; Quinazolines/pharmacokinetics ; Rats, Sprague-Dawley ; Sequence Alignment ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis and Antiplasmodial Evaluation of 4-Carboxamido- and 4-Alkoxy-2-Trichloromethyl Quinazolines.
Autorzy :
Amrane D; Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille Univ, CNRS, ICR UMR 7273, 13385 Marseille CEDEX 05, France.
Gellis A; Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille Univ, CNRS, ICR UMR 7273, 13385 Marseille CEDEX 05, France.
Hutter S; IHU Méditerranée Infection, UMR VITROME, IRD, SSA, Mycology & Tropical Eucaryotic Pathogens, Aix Marseille Univ, 13005 Marseille CEDEX 05, France.
Prieri M; Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille Univ, CNRS, ICR UMR 7273, 13385 Marseille CEDEX 05, France.
Verhaeghe P; LCC-CNRS Université de Toulouse, CNRS, UPS, 31400 Toulouse, France.
Azas N; IHU Méditerranée Infection, UMR VITROME, IRD, SSA, Mycology & Tropical Eucaryotic Pathogens, Aix Marseille Univ, 13005 Marseille CEDEX 05, France.
Vanelle P; Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille Univ, CNRS, ICR UMR 7273, 13385 Marseille CEDEX 05, France.
Primas N; Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille Univ, CNRS, ICR UMR 7273, 13385 Marseille CEDEX 05, France.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Aug 27; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials*/chemical synthesis
Antimalarials*/pharmacology
Quinazolines*/chemical synthesis
Quinazolines*/pharmacology
Plasmodium falciparum/*drug effects
Hep G2 Cells ; Humans ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Copanlisib for the treatment of adults with relapsed follicular lymphoma.
Autorzy :
Magagnoli M; Department of Oncology and Hematology, Humanitas Clinical and Research Center - IRCCS , Rozzano, Milan, Italy.
Carlo-Stella C; Department of Oncology and Hematology, Humanitas Clinical and Research Center - IRCCS , Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan, Italy.
Santoro A; Department of Oncology and Hematology, Humanitas Clinical and Research Center - IRCCS , Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan, Italy.
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Źródło :
Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2020 Aug; Vol. 13 (8), pp. 813-823. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Lymphoma, Follicular/*drug therapy
Phosphoinositide-3 Kinase Inhibitors/*administration & dosage
Pyrimidines/*administration & dosage
Quinazolines/*administration & dosage
Administration, Intravenous ; Adult ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacology ; Humans ; Lymphoma, Follicular/pathology ; Molecular Targeted Therapy ; Phosphoinositide-3 Kinase Inhibitors/adverse effects ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Pyrimidines/adverse effects ; Pyrimidines/pharmacology ; Quinazolines/adverse effects ; Quinazolines/pharmacology ; Recurrence
Czasopismo naukowe
Tytuł :
Vandetanib inhibits cell growth in EGFR-expressing cutaneous squamous cell carcinoma.
Autorzy :
Kitamura S; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan.
Maeda T; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan.
Yanagi T; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Oct 20; Vol. 531 (3), pp. 396-401. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Squamous Cell/*metabolism
Carcinoma, Squamous Cell/*pathology
ErbB Receptors/*metabolism
Piperidines/*pharmacology
Quinazolines/*pharmacology
Skin Neoplasms/*metabolism
Skin Neoplasms/*pathology
Aged ; Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Phosphorylation/drug effects ; Piperidines/administration & dosage ; Quinazolines/administration & dosage
Czasopismo naukowe
Tytuł :
[Evodiamine Promotes Apoptosis of Glioma SHG-44 Cells and Its Mechanism].
Autorzy :
Liu L; Stroke Epilepsy Wards,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
Wang X; Stroke Epilepsy Wards,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
Wang Y; Stroke Epilepsy Wards,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
Xi H; Stroke Epilepsy Wards,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
Guo J; Stroke Epilepsy Wards,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
Huang Q; Stroke Epilepsy Wards,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
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Źródło :
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2020 Oct; Vol. 42 (5), pp. 591-595.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Glioma*
Quinazolines*/pharmacology
Caspase 3/genetics ; Caspase 9/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation/drug effects ; Humans
Czasopismo naukowe

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