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Wyszukujesz frazę ""Quinazolinones"" wg kryterium: Temat


Tytuł :
Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases.
Autorzy :
Liu K; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Li D; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Zheng W; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Shi M; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Chen Y; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Tang M; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Yang T; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Zhao M; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Deng D; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Zhang C; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Liu J; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Yuan X; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Yang Z; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.; Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu 610041, China.
Chen L; Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.; Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu 610041, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 8951-8970. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Arthritis, Experimental/*drug therapy
Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors
Inflammation/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Quinazolinones/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Arthritis, Experimental/chemically induced ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Dose-Response Relationship, Drug ; Drug Discovery ; Humans ; Inflammation/chemically induced ; Mice ; Mice, Inbred DBA ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinazolinones/administration & dosage ; Quinazolinones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Binding affinity-guided design of a highly sensitive noncompetitive immunoassay for small molecule detection.
Autorzy :
Bai Y; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Wang Y; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China; Agricultural Information Institute, Chinese Academy of Agricultural Sciences, 100081 Beijing, People's Republic of China.
Li Q; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Dou L; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Liu M; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Shao S; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Zhu J; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Shen J; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Wang Z; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China.
Wen K; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China. Electronic address: .
Yu W; College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, Beijing Laboratory for Food Quality and Safety, 100193 Beijing, People's Republic of China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jul 30; Vol. 351, pp. 129270. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Limit of Detection*
Immunoassay/*methods
Piperidines/*analysis
Quinazolinones/*analysis
Antibodies, Monoclonal/immunology ; Epitopes/immunology ; Haptens/immunology ; Piperidines/immunology ; Quinazolinones/immunology
Czasopismo naukowe
Tytuł :
Analysis of the Structural Mechanism of ATP Inhibition at the AAA1 Subunit of Cytoplasmic Dynein-1 Using a Chemical "Toolkit".
Autorzy :
Tati S; School of Pharmacy, Memorial University of Newfoundland, 300 Prince Philip Dr, St. John's, NL A1B 3V6, Canada.
Alisaraie L; School of Pharmacy, Memorial University of Newfoundland, 300 Prince Philip Dr, St. John's, NL A1B 3V6, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 19; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Triphosphate/*metabolism
Dyneins/*chemistry
Quinazolinones/*metabolism
ATPases Associated with Diverse Cellular Activities/metabolism ; Binding Sites ; Biological Transport ; Computer Simulation ; Cytoplasm/metabolism ; Cytoplasmic Dyneins/chemistry ; Cytoplasmic Dyneins/metabolism ; Dyneins/antagonists & inhibitors ; Dyneins/metabolism ; Hydrolysis ; Microtubules/metabolism ; Protein Binding ; Protein Conformation ; Quinazolinones/chemistry ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Sequential Oxidative Fragmentation and Skeletal Rearrangement of Peroxides for the Synthesis of Quinazolinone Derivatives.
Autorzy :
Ubale AS; Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India.
Shaikh MA; Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India.
Gnanaprakasam B; Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Jul 16; Vol. 86 (14), pp. 9621-9636. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peroxides*
Quinazolinones*
Amines ; Oxidation-Reduction ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Synthesis of some quinazolinones inspired from the natural alkaloid L - norephedrine as EGFR inhibitors and radiosensitizers.
Autorzy :
Ghorab MM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Abdel-Kader MS; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.; Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria, Egypt.
Alqahtani AS; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Soliman AM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 218-237.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*chemical synthesis
Phenylpropanolamine/*chemistry
Quinazolinones/*chemical synthesis
Radiation-Sensitizing Agents/*chemical synthesis
Apoptosis/drug effects ; Apoptosis/radiation effects ; Binding Sites ; Cell Line ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/radiation effects ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/chemistry ; ErbB Receptors/metabolism ; Gamma Rays ; HCT116 Cells ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Molecular Docking Simulation ; Phenylpropanolamine/metabolism ; Phenylpropanolamine/pharmacology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Quinazolinones/metabolism ; Quinazolinones/pharmacology ; Radiation-Sensitizing Agents/metabolism ; Radiation-Sensitizing Agents/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity.
Autorzy :
ElZahabi HSA; Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Girls Branch, Cairo, Egypt.
Nafie MS; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.
Osman D; Pharmaceutical Chemistry Department, Faculty of Pharmacy, MSA University, Egypt.
Elghazawy NH; Drug Design and Discovery Lab, Zewail City of Science and Technology, Giza, 12578, Egypt.
Soliman DH; Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Girls Branch, Cairo, Egypt.
El-Helby AAH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Boys Branch, Cairo, Egypt.
Arafa RK; Drug Design and Discovery Lab, Zewail City of Science and Technology, Giza, 12578, Egypt; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12578, Egypt. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113609. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Quinazolinones/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; MCF-7 Cells ; Molecular Structure ; Quinazolinones/chemical synthesis ; Quinazolinones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer.
Autorzy :
Poels KE; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Data Science, Dana Farber Cancer Institute, Boston, MA, USA.
Schoenfeld AJ; Division of Solid Tumor Oncology, Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
Makhnin A; Division of Solid Tumor Oncology, Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
Tobi Y; Division of Solid Tumor Oncology, Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
Wang Y; Oncology Research and Development, Pfizer Inc, La Jolla, CA, USA.
Frisco-Cabanos H; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Chakrabarti S; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Data Science, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Shi M; Oncology Research and Development, Pfizer Inc, La Jolla, CA, USA.
Napoli C; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
McDonald TO; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Data Science, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; The Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA, USA.
Tan W; Clinical Pharmacology Oncology, Global Product Development, Pfizer Inc, San Diego, CA, USA.
Hata A; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; The Ludwig Center at Harvard, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Weinrich SL; Oncology Research and Development, Pfizer Inc, La Jolla, CA, USA.
Yu HA; Division of Solid Tumor Oncology, Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA. .
Michor F; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. .; Department of Data Science, Dana Farber Cancer Institute, Boston, MA, USA. .; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. .; The Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA, USA. .; The Ludwig Center at Harvard, Boston, MA, USA. .; The Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 17; Vol. 12 (1), pp. 3697. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Acrylamides/*administration & dosage
Acrylamides/*pharmacology
Aniline Compounds/*administration & dosage
Aniline Compounds/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*diet therapy
Quinazolinones/*administration & dosage
Quinazolinones/*pharmacology
Acrylamides/pharmacokinetics ; Acrylamides/toxicity ; Aniline Compounds/pharmacokinetics ; Aniline Compounds/toxicity ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/toxicity ; Antineoplastic Combined Chemotherapy Protocols ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/secondary ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Cohort Studies ; Computer Simulation ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Models, Statistical ; Models, Theoretical ; Mutation ; Quinazolinones/pharmacokinetics ; Quinazolinones/toxicity
Czasopismo naukowe
Tytuł :
Cytotoxicity and Antibacterial Evaluation of O-Alkylated/Acylated Quinazolin-4-one Schiff Bases.
Autorzy :
Manhas N; School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
Singh P; School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
Mocktar C; Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
Singh M; Non-Viral Gene Delivery Laboratory, Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.
Koorbanally N; School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
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Źródło :
Chemistry & biodiversity [Chem Biodivers] 2021 May; Vol. 18 (5), pp. e2100096. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Gram-Negative Bacteria/*drug effects
Gram-Positive Bacteria/*drug effects
Quinazolinones/*pharmacology
Acylation ; Alkylation ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Quinazolinones/chemical synthesis ; Quinazolinones/chemistry ; Schiff Bases/chemical synthesis ; Schiff Bases/chemistry ; Schiff Bases/pharmacology
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments.
Autorzy :
Lee JY; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Shin YS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jeon S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Lee SI; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Noh S; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Cho JE; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jang MS; Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.
Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Song JH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kim HR; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Park CM; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea; Korea University of Science and Technology, Daejeon 34114, South Korea. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 01; Vol. 39, pp. 127885. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antiviral Agents/*chemical synthesis
Middle East Respiratory Syndrome Coronavirus/*drug effects
Quinazolinones/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Cell Line ; Cell Survival/drug effects ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; Half-Life ; Humans ; Inhibitory Concentration 50 ; Mice ; Microsomes/metabolism ; Middle East Respiratory Syndrome Coronavirus/isolation & purification ; Quinazolinones/chemistry ; Quinazolinones/metabolism ; Quinazolinones/therapeutic use ; Rats ; SARS-CoV-2/isolation & purification ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors.
Autorzy :
Li P; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Liu Y; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Yang H; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China. Electronic address: .
Liu HM; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113291. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Enzyme Inhibitors/*chemical synthesis
Quinazolinones/*chemistry
Ubiquitin-Specific Peptidase 7/*antagonists & inhibitors
Animals ; Binding Sites ; Catalytic Domain ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Disease Models, Animal ; Down-Regulation/drug effects ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Molecular Docking Simulation ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Quinazolinones/metabolism ; Quinazolinones/pharmacology ; Quinazolinones/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Structure-Activity Relationship ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin-Specific Peptidase 7/metabolism ; Zebrafish
Czasopismo naukowe
Tytuł :
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
Autorzy :
Huestis MP; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Dela Cruz D; Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
DiPasquale AG; Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Durk MR; Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Eigenbrot C; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Gibbons P; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Gobbi A; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Hunsaker TL; Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
La H; Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Leung DH; Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Liu W; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Malek S; Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Merchant M; Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Moffat JG; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Muli CS; Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Orr CJ; Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Parr BT; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Shanahan F; Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Sneeringer CJ; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Wang W; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Yen I; Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Yin J; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Siu M; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Rudolph J; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3940-3955. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms/*drug therapy
Phenylurea Compounds/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
Quinazolinones/*therapeutic use
raf Kinases/*antagonists & inhibitors
Animals ; Azetidines/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Crystallography, X-Ray ; Dogs ; Drug Combinations ; Drug Synergism ; Female ; Humans ; Madin Darby Canine Kidney Cells ; Mice, Nude ; Molecular Structure ; Mutation ; Phenylurea Compounds/chemistry ; Phenylurea Compounds/metabolism ; Piperidines/therapeutic use ; Protein Binding ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Quinazolinones/chemistry ; Quinazolinones/metabolism ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays ; raf Kinases/genetics ; raf Kinases/metabolism
Czasopismo naukowe
Tytuł :
Epigenetic Therapies for Heart Failure: Current Insights and Future Potential.
Autorzy :
Napoli C; Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.
Bontempo P; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.
Palmieri V; Department of Cardiac Surgery and Transplantation, Heart Transplantation Unit in Adults of the 'Ospedali dei Colli Monaldi-Cotugno-CTO', Naples, Italy.
Coscioni E; Department of Cardiac Surgery, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Maiello C; Department of Cardiovascular Surgery and Transplants, Monaldi Hospital, Azienda dei Colli, Naples, Italy.
Donatelli F; Chair of Cardiac Surgery, Department of Cardiothoracic Center, Istituto Clinico Sant'Ambrogio, University of Milan, Milan, Italy.
Benincasa G; Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.
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Źródło :
Vascular health and risk management [Vasc Health Risk Manag] 2021 May 24; Vol. 17, pp. 247-254. Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Repositioning*
Cardiovascular Agents/*therapeutic use
Epigenesis, Genetic/*drug effects
Heart Failure/*drug therapy
Quinazolinones/*therapeutic use
Cardiovascular Agents/adverse effects ; Heart Failure/genetics ; Heart Failure/physiopathology ; Humans ; Quinazolinones/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Outcomes of patients with up to 6 years of follow-up from a phase 2 study of idelalisib for relapsed indolent lymphomas.
Autorzy :
Wagner-Johnston ND; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
Schuster SJ; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
deVos S; David Geffen School of Medicine at UCLA, Santa Monica, CA, USA.
Salles G; Hospices Civils de Lyon, University Claude Bernard, Lyon, France.
Jurczak WJ; Maria Sklodowska-Curie National Research Institute of Oncology, Kraków, Poland.
Flowers CR; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Viardot A; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.
Flinn IW; Hematologic Malignancies Research Program, Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA.
Martin P; Division of Hematology/Oncology, Weill Cornell Medical College, New York, NY, USA.
Xing G; Gilead Sciences, Inc., Foster City, CA, USA.
Rajakumaraswamy N; Gilead Sciences, Inc., Foster City, CA, USA.
Gopal AK; University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2021 May; Vol. 62 (5), pp. 1077-1087. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphoma, Non-Hodgkin*/drug therapy
Quinazolinones*/adverse effects
Antineoplastic Combined Chemotherapy Protocols ; Follow-Up Studies ; Humans ; Purines/adverse effects ; Rituximab/adverse effects
Czasopismo naukowe
Tytuł :
Mdivi-1 alleviates brain damage and synaptic dysfunction after intracerebral hemorrhage in mice.
Autorzy :
Zhang Y; Institute of Forensic Science, Changzhou De'an Hospital, Changzhou, 213003, Jiangsu, China.
Rui T; Department of Forensic Medicine, Medical College of Soochow University, Suzhou, 215123, Jiangsu, China.
Luo C; Department of Forensic Medicine, Medical College of Soochow University, Suzhou, 215123, Jiangsu, China. .
Li Q; School of Forensic Medicine, Wannan Medical College, Wuhu, 241002, Anhui, China. .
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Źródło :
Experimental brain research [Exp Brain Res] 2021 May; Vol. 239 (5), pp. 1581-1593. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Injuries*
Quinazolinones*/pharmacology
Animals ; Blood-Brain Barrier ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/drug therapy ; Mice ; Mitochondrial Dynamics
Czasopismo naukowe
Tytuł :
Idelalisib in indolent NHL - has it finally found its niche?
Autorzy :
Sekar A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2021 May; Vol. 62 (5), pp. 1029-1030. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Lymphoma, Non-Hodgkin*
Quinazolinones*/adverse effects
Follow-Up Studies ; Humans ; Purines
Czasopismo naukowe
Tytuł :
Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones.
Autorzy :
Einsiedler M; Department of Chemistry and Food Chemistry, Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069, Dresden, Germany.
Jamieson CS; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095-1569, USA.
Maskeri MA; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095-1569, USA.
Houk KN; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095-1569, USA.
Gulder TAM; Department of Chemistry and Food Chemistry, Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069, Dresden, Germany.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Apr 06; Vol. 60 (15), pp. 8297-8302. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Dioxygenases/*metabolism
Quinazolinones/*metabolism
Quinolones/*metabolism
Aspergillus nidulans/enzymology ; Biocatalysis ; Molecular Structure ; Quinazolinones/chemistry ; Quinolones/chemistry
Czasopismo naukowe
Tytuł :
Antioxidant, Cytotoxic, Genotoxic, and DNA-Protective Potential of 2,3-Substituted Quinazolinones: Structure-Activity Relationship Study.
Autorzy :
Hricovíniová J; Cancer Research Institute BMC, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia.
Hricovíniová Z; Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia.
Kozics K; Cancer Research Institute BMC, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 09; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antimutagenic Agents/*pharmacology
Antioxidants/*pharmacology
DNA Damage/*drug effects
Quinazolinones/*pharmacology
Antimutagenic Agents/chemistry ; Antimutagenic Agents/toxicity ; Antioxidants/chemistry ; Antioxidants/toxicity ; Cell Line ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA/genetics ; Humans ; Hydrogen Peroxide/toxicity ; Mutagens/toxicity ; Oxidants/toxicity ; Quinazolinones/chemistry ; Quinazolinones/toxicity ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive molecules.
Autorzy :
Plescia F; Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche - Sezione di Chimica e Tecnologie Farmaceutiche - Università Degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy.
Maggio B; Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche - Sezione di Chimica e Tecnologie Farmaceutiche - Università Degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy.
Daidone G; Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche - Sezione di Chimica e Tecnologie Farmaceutiche - Università Degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy.
Raffa D; Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche - Sezione di Chimica e Tecnologie Farmaceutiche - Università Degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113070. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Quinazolinones/*chemistry
Animals ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anticonvulsants/chemistry ; Anticonvulsants/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Benzothiazoles/chemistry ; Bronchodilator Agents/chemistry ; Bronchodilator Agents/pharmacology ; Humans ; Molecular Structure ; Nitrogen/chemistry ; Oxygen/chemistry ; Quinazolinones/pharmacology ; Sulfur/chemistry ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Design, synthesis, characterization, enzymatic inhibition evaluations, and docking study of novel quinazolinone derivatives.
Autorzy :
Pedrood K; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Sherafati M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadi-Khanaposhtani M; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Asgari MS; Department of Chemistry, Iran University of Science and Technology, Tehran, Iran.
Hosseini S; Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rastegar H; Cosmetic Products Research Center, Iranian Food and Drug Administration, MOHE, Tehran, Iran.
Larijani B; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
Taslimi P; Department of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, Turkey. Electronic address: .
Erden Y; Department of Molecular Biology and Genetics, Faculty of Science, Bartin University, 74100 Bartin, Turkey.
Günay S; Department of Molecular Biology and Genetics, Faculty of Science, Bartin University, 74100 Bartin, Turkey.
Gulçin İ; Department of Chemistry, Faculty of Sciences, Ataturk University, 25240, Erzurum, Turkey.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Feb 15; Vol. 170, pp. 1-12. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji :
Journal Article
MeSH Terms :
Carbonic Anhydrase Inhibitors/*chemistry
Cholinesterase Inhibitors/*chemistry
Glycoside Hydrolase Inhibitors/*chemistry
Quinazolinones/*chemistry
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/toxicity ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/pharmacology ; Carbonic Anhydrase Inhibitors/toxicity ; Cell Line, Tumor ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/toxicity ; Drug Design ; Drug Screening Assays, Antitumor ; Female ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/toxicity ; Humans ; Kinetics ; MCF-7 Cells ; Male ; Molecular Docking Simulation ; Molecular Structure ; Prostatic Neoplasms/pathology ; Quinazolinones/chemical synthesis ; Quinazolinones/pharmacology ; Quinazolinones/toxicity ; Structure-Activity Relationship ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma.
Autorzy :
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: .
Ibrahim MK; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Metwaly AM; Pharmacognosy Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Belal A; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Mehany ABM; Zoology Department, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt.
Abdelhady AA; Department of Anatomy, Faculty of Medicine, Helwan University, Cairo, Egypt.
Elhendawy MA; National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Department of Agriculture Chemistry, Faculty of Agriculture, Damietta University, Damietta, Egypt.
Radwan MM; National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
ElSohly MA; National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Department of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Feb; Vol. 107, pp. 104532. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Quinazolinones/*therapeutic use
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; G1 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase Cell Cycle Checkpoints/drug effects ; Hep G2 Cells ; Humans ; Liver Neoplasms/pathology ; Male ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacokinetics ; Quinazolinones/chemical synthesis ; Quinazolinones/metabolism ; Quinazolinones/pharmacokinetics ; Rats ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe

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