Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Quinolizines"" wg kryterium: Temat


Tytuł :
Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways.
Autorzy :
Zhu L; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China; Lung Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Huang S; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China.
Li J; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China.
Chen J; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China.
Yao Y; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China.
Li L; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China.
Guo H; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China.
Xiang X; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China. Electronic address: .
Deng J; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China. Electronic address: .
Xiong J; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China. Electronic address: .
Pokaż więcej
Źródło :
Gene [Gene] 2020 Jun 05; Vol. 742, pp. 144556. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE
MeSH Terms :
Alkaloids/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cisplatin/*pharmacology
Lung Neoplasms/*drug therapy
Quinolizines/*pharmacology
Alkaloids/therapeutic use ; Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation ; Cell Survival/drug effects ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Female ; Humans ; Lung/pathology ; Lung Neoplasms/pathology ; Male ; Mice ; Protein-Serine-Threonine Kinases/metabolism ; Quinolizines/therapeutic use ; Signal Transduction/drug effects ; Sophora/chemistry ; Tumor Burden/drug effects ; Tumor Suppressor Protein p53/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
In vitro inhibitory effects of phellodendrine on human liver cytochrome P450 enzymes.
Autorzy :
Li J; Department of Pharmacy, Binzhou People's Hospital, Binzhou, Shandong Province, China.
Wen H; Department of Pharmacy, Zouping Traditional Chinese Hospital, Binzhou, Shandong Province, China.
Gao Z; Department of Pharmacy, Weifang No. 2 People's Hospital, Weifang, Shandong Province, China.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Feb; Vol. 50 (2), pp. 231-236. Date of Electronic Publication: 2019 May 15.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE
MeSH Terms :
Cytochrome P-450 Enzyme Inhibitors/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Quinolizines/*metabolism
Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Humans ; Liver/metabolism ; Quinolizines/pharmacology
Czasopismo naukowe
Tytuł :
A Validated Ultra-Performance Liquid Chromatographic Method for the Simultaneous Determination of Nadifloxacin, Mometasone Furoate and Miconazole Nitrate in Their Combined Dosage Form and Spiked Human Plasma Samples.
Autorzy :
Tarek M; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo 11837, Egypt.; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo 11837, Egypt.
Wagdy HA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo 11837, Egypt.; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo 11837, Egypt.
Elzanfaly ES; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, Cairo 11562, Egypt.
Amer SM; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, Cairo 11562, Egypt.
Pokaż więcej
Źródło :
Journal of chromatographic science [J Chromatogr Sci] 2020 Jan 17; Vol. 57 (10), pp. 867-873.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Oxford University Press Country of Publication: United States NLM ID: 0173225 Publication Model: Print Cited Medium: Internet ISSN: 1945-239X (Electronic) Linking ISSN: 00219665 NLM ISO Abbreviation: J Chromatogr Sci Subsets: MEDLINE
MeSH Terms :
Chromatography, High Pressure Liquid/*methods
Fluoroquinolones/*analysis
Miconazole/*analysis
Mometasone Furoate/*analysis
Quinolizines/*analysis
Chromatography, Reverse-Phase ; Fluoroquinolones/blood ; Fluoroquinolones/chemistry ; Humans ; Limit of Detection ; Linear Models ; Miconazole/blood ; Miconazole/chemistry ; Mometasone Furoate/blood ; Mometasone Furoate/chemistry ; Quinolizines/blood ; Quinolizines/chemistry ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Concentrations of medetomidine enantiomers and vatinoxan, an α 2 -adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs.
Autorzy :
Honkavaara JM; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland. Electronic address: .
Raekallio MR; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Syrja PM; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Pypendop BH; Department of Radiological and Surgical Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Knych HK; Kenneth L. Maddy Equine Analytical Chemistry Laboratory, School of Veterinary Medicine, University of California, Davis, CA, USA.
Kallio-Kujala IJ; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Vainio OM; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Pokaż więcej
Źródło :
Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2020 Jan; Vol. 47 (1), pp. 47-52. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article; Observational Study, Veterinary
Journal Info :
Publisher: Elsevier Country of Publication: United States NLM ID: 100956422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-2995 (Electronic) Linking ISSN: 14672987 NLM ISO Abbreviation: Vet Anaesth Analg Subsets: MEDLINE
MeSH Terms :
Adrenergic alpha-2 Receptor Antagonists/*pharmacokinetics
Dogs/*metabolism
Hypnotics and Sedatives/*pharmacokinetics
Medetomidine/*pharmacokinetics
Quinolizines/*pharmacokinetics
Adrenergic alpha-2 Receptor Antagonists/administration & dosage ; Adrenergic alpha-2 Receptor Antagonists/blood ; Animals ; Brain/metabolism ; Drug Therapy, Combination/veterinary ; Female ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/blood ; Infusions, Intravenous/veterinary ; Male ; Medetomidine/administration & dosage ; Medetomidine/blood ; Nerve Tissue/metabolism ; Quinolizines/administration & dosage ; Quinolizines/blood
Czasopismo naukowe
Tytuł :
Pharmacokinetics of vatinoxan in male neutered cats anesthetized with isoflurane.
Autorzy :
Pypendop BH; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address: .
Ahokoivu H; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Honkavaara J; Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA.
Pokaż więcej
Źródło :
Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2020 Jan; Vol. 47 (1), pp. 70-75. Date of Electronic Publication: 2019 Oct 24.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: United States NLM ID: 100956422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-2995 (Electronic) Linking ISSN: 14672987 NLM ISO Abbreviation: Vet Anaesth Analg Subsets: MEDLINE
MeSH Terms :
Anesthesia/*veterinary
Cats/*metabolism
Quinolizines/*pharmacokinetics
Anesthetics, Inhalation/therapeutic use ; Animals ; Infusions, Intravenous ; Isoflurane/therapeutic use ; Male ; Orchiectomy ; Quinolizines/administration & dosage ; Quinolizines/blood
Czasopismo naukowe
Tytuł :
Pharmacokinetics of dexmedetomidine during administration of vatinoxan in male neutered cats anesthetized with isoflurane.
Autorzy :
Pypendop BH; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Ahokoivu H; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Honkavaara J; School of Veterinary Medicine, Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
Pokaż więcej
Źródło :
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2020 Jan; Vol. 43 (1), pp. 1-5. Date of Electronic Publication: 2019 Jul 18.
Typ publikacji :
Clinical Trial, Veterinary; Journal Article
Journal Info :
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7910920 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2885 (Electronic) Linking ISSN: 01407783 NLM ISO Abbreviation: J Vet Pharmacol Ther Subsets: MEDLINE
MeSH Terms :
Anesthesia/*veterinary
Cats/*physiology
Dexmedetomidine/*pharmacokinetics
Isoflurane/*pharmacology
Quinolizines/*pharmacokinetics
Anesthetics, Inhalation/administration & dosage ; Anesthetics, Inhalation/pharmacology ; Animals ; Dexmedetomidine/administration & dosage ; Dexmedetomidine/pharmacology ; Drug Interactions ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/pharmacokinetics ; Hypnotics and Sedatives/pharmacology ; Isoflurane/administration & dosage ; Male ; Quinolizines/administration & dosage ; Quinolizines/pharmacology
Czasopismo naukowe
Tytuł :
Cardiopulmonary effects of dexmedetomidine, with and without vatinoxan, in isoflurane-anesthetized cats.
Autorzy :
Jaeger AT; William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA.
Pypendop BH; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address: .
Ahokoivu H; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Honkavaara J; William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA.
Pokaż więcej
Źródło :
Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2019 Nov; Vol. 46 (6), pp. 753-764. Date of Electronic Publication: 2019 Jun 17.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
Journal Info :
Publisher: Elsevier Country of Publication: United States NLM ID: 100956422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-2995 (Electronic) Linking ISSN: 14672987 NLM ISO Abbreviation: Vet Anaesth Analg Subsets: MEDLINE
MeSH Terms :
Cats*
Blood Pressure/*drug effects
Dexmedetomidine/*pharmacokinetics
Isoflurane/*pharmacology
Quinolizines/*pharmacokinetics
Adrenergic alpha-2 Receptor Antagonists/administration & dosage ; Adrenergic alpha-2 Receptor Antagonists/pharmacokinetics ; Adrenergic alpha-2 Receptor Antagonists/pharmacology ; Anesthetics, Inhalation/administration & dosage ; Anesthetics, Inhalation/pharmacokinetics ; Anesthetics, Inhalation/pharmacology ; Animals ; Cross-Over Studies ; Dexmedetomidine/administration & dosage ; Dexmedetomidine/blood ; Dexmedetomidine/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Heart Rate/drug effects ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/pharmacokinetics ; Hypnotics and Sedatives/pharmacology ; Hypotension/chemically induced ; Hypotension/veterinary ; Isoflurane/administration & dosage ; Male ; Quinolizines/administration & dosage ; Quinolizines/pharmacology ; Vascular Resistance/drug effects
Czasopismo naukowe
Tytuł :
Targeting ERK/COX-2 signaling pathway in permethrin-induced testicular toxicity: a possible modulating effect of matrine.
Autorzy :
Atef MM; Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt. .
El-Deeb OS; Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Sadek MT; Histology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abo El Gheit RE; Physiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Emam MN; Physiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Hafez YM; Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
El-Esawy RO; Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Pokaż więcej
Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Jan; Vol. 47 (1), pp. 247-259. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol. Biol. Rep. Subsets: MEDLINE
MeSH Terms :
Alkaloids/*metabolism
Phosphoproteins/*metabolism
Quinolizines/*metabolism
Testis/*drug effects
Alkaloids/pharmacology ; Animals ; Antioxidants/metabolism ; Cyclooxygenase 2/metabolism ; Glutathione Peroxidase/metabolism ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology ; Male ; Malondialdehyde/analysis ; Permethrin/adverse effects ; Permethrin/toxicity ; Phosphoproteins/genetics ; Quinolizines/pharmacology ; Rats ; Rats, Wistar ; Signal Transduction ; Spermatozoa/cytology ; Spermatozoa/drug effects ; Testis/cytology ; Testis/metabolism ; Testosterone/analysis
Czasopismo naukowe
Tytuł :
Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence.
Autorzy :
Bhagwat SS; Department of Microbiology, Wockhardt Research Centre, Aurangabad, India.
Nandanwar M; Department of Toxicology, Wockhardt Research Centre, Aurangabad, India.
Kansagara A; Department of Toxicology, Wockhardt Research Centre, Aurangabad, India.
Patel A; Department of Safety Pharmacology, Wockhardt Research Centre, Aurangabad, India.
Takalkar S; Department of Microbiology, Wockhardt Research Centre, Aurangabad, India.
Chavan R; Department of Drug Metabolism and Pharmacokinetics, Wockhardt Research Centre, Aurangabad, India.
Periasamy H; Department of Microbiology, Wockhardt Research Centre, Aurangabad, India.
Yeole R; Department of Analytical Chemistry, Wockhardt Research Centre, Aurangabad, India.
Deshpande PK; Department of Medicinal Chemistry, Wockhardt Research Centre, Aurangabad, India.
Bhavsar S; Department of Medicinal Chemistry, Wockhardt Research Centre, Aurangabad, India.
Bhatia A; Global Clinical Operations, Wockhardt Ltd, Mumbai, India.
Ahdal J; Department of Medical Affairs, Wockhardt Ltd, Mumbai, India.
Jain R; Department of Medical Affairs, Wockhardt Ltd, Mumbai, India.
Patel M; Drug Discovery Research, Wockhardt Research Centre, Aurangabad, India.
Pokaż więcej
Źródło :
Drug design, development and therapy [Drug Des Devel Ther] 2019 Dec 24; Vol. 13, pp. 4351-4365. Date of Electronic Publication: 2019 Dec 24 (Print Publication: 2019).
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Methicillin-Resistant Staphylococcus aureus/*drug effects
Quinolizines/*pharmacology
Animals ; Anti-Bacterial Agents/chemistry ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Quinolizines/chemistry
Czasopismo naukowe
Tytuł :
Preparation of Matrinic/Oxymatrinic Amide Derivatives as Insecticidal/Acaricidal Agents and Study on the Mechanisms of Action against Tetranychus cinnabarinus .
Autorzy :
Xu H; Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi Province 712100 , China.; School of Pharmacy , Liaocheng University , Liaocheng , Shandong Province 252059 , China.
Xu M; Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi Province 712100 , China.
Sun Z; Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi Province 712100 , China.
Li S; Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi Province 712100 , China.
Pokaż więcej
Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2019 Nov 06; Vol. 67 (44), pp. 12182-12190. Date of Electronic Publication: 2019 Oct 25.
Typ publikacji :
Journal Article
Journal Info :
Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J. Agric. Food Chem. Subsets: MEDLINE
MeSH Terms :
Acaricides/*chemistry
Alkaloids/*chemistry
Amides/*chemistry
Insecticides/*chemistry
Quinolizines/*chemistry
Acaricides/chemical synthesis ; Acaricides/pharmacology ; Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Alkaloids/pharmacology ; Amides/pharmacology ; Animals ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Female ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Insecticides/chemical synthesis ; Insecticides/pharmacology ; Molecular Structure ; Moths/drug effects ; Moths/genetics ; Moths/growth & development ; Moths/metabolism ; Quinolizines/pharmacology ; Structure-Activity Relationship ; Tetranychidae/drug effects ; Tetranychidae/genetics ; Tetranychidae/growth & development ; Tetranychidae/metabolism
Czasopismo naukowe
Tytuł :
Total Synthesis of (-)-Himeradine A.
Autorzy :
Burtea A; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, CA, 92697, USA.
DeForest J; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, CA, 92697, USA.
Li X; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, CA, 92697, USA.
Rychnovsky SD; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, CA, 92697, USA.
Pokaż więcej
Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Nov 04; Vol. 58 (45), pp. 16193-16197. Date of Electronic Publication: 2019 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Subsets: MEDLINE
MeSH Terms :
Piperidines/*chemistry
Pyridines/*chemistry
Quinolizines/*chemical synthesis
Catalysis ; Cyclization ; Molecular Structure ; Quinolizines/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Oxymatrine may represent an additional therapeutic tool in severe plaque psoriasis management.
Autorzy :
Groma G; University of Szeged, Department of Dermatology and Allergology, Szeged, Hungary.; MTA-SZTE Dermatological Research Group, Szeged, Hungary.
Pokaż więcej
Źródło :
The British journal of dermatology [Br J Dermatol] 2019 Nov; Vol. 181 (5), pp. 891-892. Date of Electronic Publication: 2019 Aug 07.
Typ publikacji :
Journal Article; Comment
Journal Info :
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0004041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2133 (Electronic) Linking ISSN: 00070963 NLM ISO Abbreviation: Br. J. Dermatol. Subsets: MEDLINE
MeSH Terms :
Psoriasis*
Quinolizines*
Alkaloids ; Apoptosis ; Cell Proliferation ; Humans
Czasopismo naukowe
Tytuł :
Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy.
Autorzy :
Wang MR; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, Henan, China.
Zhang XJ; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Liu HC; Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Ma WD; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Zhang ML; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Zhang Y; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, Shaanxi, China.
Li X; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, Shaanxi, China.
Dou MM; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, Henan, China.
Jing YL; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, Henan, China.
Chu YJ; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Zhu L; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China. Electronic address: .
Pokaż więcej
Źródło :
Brain research bulletin [Brain Res Bull] 2019 Nov; Vol. 153, pp. 30-38. Date of Electronic Publication: 2019 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res. Bull. Subsets: MEDLINE
MeSH Terms :
Alkaloids/*pharmacology
Oligodendroglia/*drug effects
Quinolizines/*pharmacology
Alkaloids/metabolism ; Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Central Nervous System/metabolism ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Mitochondria/metabolism ; Multiple Sclerosis/pathology ; Oligodendroglia/metabolism ; Quinolizines/metabolism ; Rats ; Rats, Wistar ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Pharmacological Approach to Smoking Cessation: An Updated Review for Daily Clinical Practice.
Autorzy :
Giulietti F; Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Pulmonology and Respiratory Medicine Clinic, Centre for Smoking Cessation, IRCCS INRCA, Ancona, Italy.; Department of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy.
Filipponi A; Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Pulmonology and Respiratory Medicine Clinic, Centre for Smoking Cessation, IRCCS INRCA, Ancona, Italy.; Department of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy.
Rosettani G; Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Pulmonology and Respiratory Medicine Clinic, Centre for Smoking Cessation, IRCCS INRCA, Ancona, Italy.; Department of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy.
Giordano P; Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Pulmonology and Respiratory Medicine Clinic, Centre for Smoking Cessation, IRCCS INRCA, Ancona, Italy.
Iacoacci C; Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Pulmonology and Respiratory Medicine Clinic, Centre for Smoking Cessation, IRCCS INRCA, Ancona, Italy.
Spannella F; Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Pulmonology and Respiratory Medicine Clinic, Centre for Smoking Cessation, IRCCS INRCA, Ancona, Italy.; Department of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy.
Sarzani R; Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Pulmonology and Respiratory Medicine Clinic, Centre for Smoking Cessation, IRCCS INRCA, Ancona, Italy. .; Department of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy. .
Pokaż więcej
Źródło :
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension [High Blood Press Cardiovasc Prev] 2020 Oct; Vol. 27 (5), pp. 349-362. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9421087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1985 (Electronic) Linking ISSN: 11209879 NLM ISO Abbreviation: High Blood Press Cardiovasc Prev Subsets: MEDLINE
MeSH Terms :
Smoking Cessation*
Alkaloids/*therapeutic use
Bupropion/*therapeutic use
Smoking/*adverse effects
Smoking Cessation Agents/*therapeutic use
Tobacco Use Disorder/*drug therapy
Varenicline/*therapeutic use
Alkaloids/adverse effects ; Azocines/adverse effects ; Azocines/therapeutic use ; Bupropion/adverse effects ; Clinical Decision-Making ; Electronic Nicotine Delivery Systems ; Humans ; Quinolizines/adverse effects ; Quinolizines/therapeutic use ; Recurrence ; Risk Factors ; Smoking Cessation Agents/adverse effects ; Tobacco Use Cessation Devices ; Tobacco Use Disorder/diagnosis ; Tobacco Use Disorder/physiopathology ; Tobacco Use Disorder/psychology ; Treatment Outcome ; Varenicline/adverse effects
Czasopismo naukowe
Tytuł :
Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways.
Autorzy :
Zhang X; Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hou G; Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu A; Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xu H; Ultrastructural Pathology Laboratory, Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Guan Y; Ultrastructural Pathology Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Wu Y; The Institute of Cancer Molecular Mechanisms & Drug Targets, Henan University of Traditional Chinese Medicine, Zhengzhou, 450046, China.
Deng J; Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Cao X; Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .
Pokaż więcej
Źródło :
Cell death & disease [Cell Death Dis] 2019 Oct 10; Vol. 10 (10), pp. 770. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
MeSH Terms :
Alkaloids/*therapeutic use
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Ovarian Neoplasms/*drug therapy
Ovarian Neoplasms/*metabolism
Quinolizines/*therapeutic use
Alkaloids/adverse effects ; Alkaloids/pharmacology ; Animals ; Apoptosis/drug effects ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagosomes/ultrastructure ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Female ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Focal Adhesion Kinase 1/chemistry ; Focal Adhesion Kinase 1/metabolism ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neovascularization, Pathologic/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/chemistry ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/chemistry ; Proto-Oncogene Proteins c-akt/metabolism ; Quinolizines/adverse effects ; Quinolizines/pharmacology ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/chemistry ; TOR Serine-Threonine Kinases/metabolism ; Transplantation, Heterologous ; rhoA GTP-Binding Protein/antagonists & inhibitors ; rhoA GTP-Binding Protein/chemistry ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine.
Autorzy :
Tapio HA; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014, Finland. Electronic address: .
Raekallio MR; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014, Finland.
Mykkänen AK; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014, Finland.
Al-Ramahi D; Bioanalytical Laboratory, Institute of Biomedicine, Kiinamyllynkatu 10, 20520 Turku, Finland; Unit of Clinical Pharmacology, Turku University Hospital, P.O. Box 52, 20521 Turku, Finland.
Scheinin M; Bioanalytical Laboratory, Institute of Biomedicine, Kiinamyllynkatu 10, 20520 Turku, Finland; Unit of Clinical Pharmacology, Turku University Hospital, P.O. Box 52, 20521 Turku, Finland.
Hautajärvi HJ; Admescope Ltd., Typpitie 1, 90620 Oulu, Finland.
Männikkö S; 4Pharma Ltd., Tykistökatu 4D, 20520 Turku, Finland.
Vainio O; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014, Finland.
Pokaż więcej
Źródło :
Veterinary journal (London, England : 1997) [Vet J] 2019 Sep; Vol. 251, pp. 105345. Date of Electronic Publication: 2019 Jul 27.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Balliere Tindall Country of Publication: England NLM ID: 9706281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2971 (Electronic) Linking ISSN: 10900233 NLM ISO Abbreviation: Vet. J. Subsets: MEDLINE
MeSH Terms :
Gastrointestinal Motility/*drug effects
Isoflurane/*pharmacology
Medetomidine/*pharmacology
Quinolizines/*pharmacology
Adrenergic alpha-2 Receptor Antagonists ; Anesthesia, Inhalation/veterinary ; Anesthetics, Inhalation/administration & dosage ; Anesthetics, Inhalation/pharmacology ; Animals ; Blood Pressure/drug effects ; Cardiovascular Physiological Phenomena/drug effects ; Cross-Over Studies ; Female ; Heart Rate/drug effects ; Horses ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/pharmacology ; Isoflurane/administration & dosage ; Male ; Medetomidine/administration & dosage ; Quinolizines/blood ; Quinolizines/pharmacokinetics
Czasopismo naukowe
Tytuł :
Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models.
Autorzy :
Halim CE; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
Xinjing SL; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
Fan L; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
Bailey Vitarbo J; Narula Research, Chapel Hill, NC, 27516, USA.
Arfuso F; Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, 6102, Australia.
Tan CH; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
Narula AS; Narula Research, Chapel Hill, NC, 27516, USA.
Kumar AP; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore; Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore; Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address: .
Ahn KS; College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Pharmacological research [Pharmacol Res] 2019 Sep; Vol. 147, pp. 104327. Date of Electronic Publication: 2019 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol. Res. Subsets: MEDLINE
MeSH Terms :
Alkaloids/*therapeutic use
Antineoplastic Agents, Phytogenic/*therapeutic use
Neoplasms/*drug therapy
Quinolizines/*therapeutic use
Alkaloids/chemistry ; Alkaloids/pharmacology ; Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Disease Models, Animal ; Humans ; Quinolizines/chemistry ; Quinolizines/pharmacology
Czasopismo naukowe
Tytuł :
Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease.
Autorzy :
Zhang H; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China.
Yang L; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China.
Wang Y; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China.
Huang W; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China.
Li Y; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China.
Chen S; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China.
Song G; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China.
Ren L; Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, China. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118090. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Alkaloids/*pharmacology
Lipid Metabolism/*drug effects
MicroRNAs/*genetics
Non-alcoholic Fatty Liver Disease/*drug therapy
Quinolizines/*pharmacology
Animals ; Body Weight/drug effects ; Diet, High-Fat ; Gene Knockdown Techniques ; Hep G2 Cells ; Humans ; Insulin Resistance ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/physiopathology ; Palmitic Acid/administration & dosage ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Levonadifloxacin arginine salt to treat acute bacterial skin and skin structure infection due to S. aureus including MRSA.
Autorzy :
Saxena D; Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Kaul G; Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Dasgupta A; Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Chopra S; Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India. .
Pokaż więcej
Źródło :
Drugs of today (Barcelona, Spain : 1998) [Drugs Today (Barc)] 2020 Sep; Vol. 56 (9), pp. 583-598.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Clarivate Analytics Country of Publication: Spain NLM ID: 101160518 Publication Model: Print Cited Medium: Print ISSN: 1699-3993 (Print) Linking ISSN: 16993993 NLM ISO Abbreviation: Drugs Today (Barc) Subsets: MEDLINE
MeSH Terms :
Anti-Bacterial Agents/*therapeutic use
Quinolizines/*therapeutic use
Quinolones/*therapeutic use
Staphylococcal Skin Infections/*drug therapy
Clinical Trials as Topic ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Staphylococcus aureus/drug effects
Czasopismo naukowe
Tytuł :
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
Autorzy :
Liu Y; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China; College of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu Province, 210009, PR China.
Wang H; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China.
Liu N; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China.
Du J; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China.
Lan X; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China.
Qi X; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China.
Zhuang C; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China; College of Pharmacy, the Second Military Medical University, Shanghai, 200433, PR China.
Sun T; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China.
Li Y; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China.
Yu J; College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China; Ningxia Hui Medicine Modern Engineering Research Center, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China; Collaborative Innovation Center, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, PR China. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Aug 01; Vol. 254, pp. 116444. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Alkaloids/*pharmacology
Glycogen Synthase Kinase 3 beta/*metabolism
Hypoxia-Ischemia, Brain/*prevention & control
Neuroprotective Agents/*pharmacology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Quinolizines/*pharmacology
Animals ; Animals, Newborn ; Behavior, Animal/drug effects ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies