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Tytuł :
Health risks associated with sulfonamide and quinolone residues in cultured Chinese mitten crab (Eriocheir sinensis) in China.
Autorzy :
Fang L; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, Wuxi 214081, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing 100000, PR China.
Huang Z; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, Wuxi 214081, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing 100000, PR China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, PR China.
Fan L; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, Wuxi 214081, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing 100000, PR China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, PR China.
Hu G; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, Wuxi 214081, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing 100000, PR China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, PR China.
Qiu L; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, Wuxi 214081, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing 100000, PR China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, PR China.
Song C; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, Wuxi 214081, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing 100000, PR China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, PR China. Electronic address: .
Chen J; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, Wuxi 214081, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing 100000, PR China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, PR China. Electronic address: .
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Źródło :
Marine pollution bulletin [Mar Pollut Bull] 2021 Apr; Vol. 165, pp. 112184. Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Brachyura*
Quinolones*
Animals ; China ; Sulfanilamide ; Sulfonamides
Czasopismo naukowe
Tytuł :
In vivo and in silico evaluations of survival and cardiac developmental toxicity of quinolone antibiotics in zebrafish embryos (Danio rerio).
Autorzy :
Han Y; Division of Antibiotics, Institute for Chemical Drug Control, National Institutes for Food and Drug Control, Beijing, 102629, China.
Ma Y; Department of Pharmacology, NHC Key Laboratory of Biotechnology of Antibiotics, Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yao S; Division of Antibiotics, Institute for Chemical Drug Control, National Institutes for Food and Drug Control, Beijing, 102629, China.
Zhang J; Department of Pharmacology, NHC Key Laboratory of Biotechnology of Antibiotics, Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: .
Hu C; Division of Antibiotics, Institute for Chemical Drug Control, National Institutes for Food and Drug Control, Beijing, 102629, China. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 May 15; Vol. 277, pp. 116779. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Quinolones*/toxicity
Zebrafish*
Animals ; Anti-Bacterial Agents/toxicity ; China ; Computer Simulation ; Embryo, Nonmammalian
Czasopismo naukowe
Tytuł :
Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human.
Autorzy :
Sasabe H; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Koga T; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Furukawa M; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Matsunaga M; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Kaneko Y; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Koyama N; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Hirao Y; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Akazawa H; Department of CNS research, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Kawabata M; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd, Kainan, Wakayama, Japan.
Kashiyama E; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
Takeuchi K; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 May; Vol. 51 (5), pp. 590-604. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Dopamine*
Quinolones*
Animals ; Haplorhini ; Humans ; Rats ; Serotonin ; Thiophenes
Czasopismo naukowe
Tytuł :
Regulation of biochar mediated catalytic degradation of quinolone antibiotics: Important role of environmentally persistent free radicals.
Autorzy :
Zhang Y; School of Environment, Henan Normal University, Key Laboratory for Yellow River and Huai River Water Environmental and Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, International Joint Laboratory on Key Techniques in Water Treatment, Xinxiang, Henan 453007, PR China. Electronic address: .
Xu M; School of Environment, Henan Normal University, Key Laboratory for Yellow River and Huai River Water Environmental and Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, International Joint Laboratory on Key Techniques in Water Treatment, Xinxiang, Henan 453007, PR China.
Liu X; School of Environment, Henan Normal University, Key Laboratory for Yellow River and Huai River Water Environmental and Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, International Joint Laboratory on Key Techniques in Water Treatment, Xinxiang, Henan 453007, PR China.
Wang M; Beijing Drainage Group Co., Ltd., Beijing 100044, PR China.
Zhao J; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, PR China.
Li S; School of Environment, Henan Normal University, Key Laboratory for Yellow River and Huai River Water Environmental and Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, International Joint Laboratory on Key Techniques in Water Treatment, Xinxiang, Henan 453007, PR China.
Yin M; School of Environment, Henan Normal University, Key Laboratory for Yellow River and Huai River Water Environmental and Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, International Joint Laboratory on Key Techniques in Water Treatment, Xinxiang, Henan 453007, PR China.
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Źródło :
Bioresource technology [Bioresour Technol] 2021 Apr; Vol. 326, pp. 124780. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Hydrogen Peroxide*
Quinolones*
Anti-Bacterial Agents ; Charcoal ; Ecosystem ; Free Radicals
Czasopismo naukowe
Tytuł :
Easily accessed nitroquinolones exhibiting potent and selective anti-tubercular activity.
Autorzy :
Dube PS; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa.
Legoabe LJ; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa.
Jordaan A; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town, Observatory, 7925, South Africa.
Jesumoroti OJ; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa.
Tshiwawa T; Faculty of Science, Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.
Warner DF; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town, Observatory, 7925, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, 7701, South Africa; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Faculty of Health Sciences, University of Cape Town, Rondebosch, 7701, South Africa.
Beteck RM; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113207. Date of Electronic Publication: 2021 Jan 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents/*pharmacology
Mycobacterium tuberculosis/*drug effects
Nitro Compounds/*pharmacology
Quinolones/*pharmacology
Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Nitro Compounds/chemical synthesis ; Nitro Compounds/chemistry ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Easy-To-Access Quinolone Derivatives Exhibiting Antibacterial and Anti-Parasitic Activities.
Autorzy :
Beteck RM; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa.
Jordaan A; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
Seldon R; SAMRC Drug Discovery and Development Research Unit, University of Cape Town, Cape Town 7700, South Africa.
Laming D; Centre for Chemico- and Biomedicinal Research, Rhodes University, Makhanda 6140, South Africa.
Hoppe HC; Centre for Chemico- and Biomedicinal Research, Rhodes University, Makhanda 6140, South Africa.; Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.
Warner DF; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town 7925, South Africa.
Khanye SD; Centre for Chemico- and Biomedicinal Research, Rhodes University, Makhanda 6140, South Africa.; Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 20; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antiprotozoal Agents/*pharmacology
Quinolones/*pharmacology
Acinetobacter baumannii/drug effects ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium falciparum/drug effects ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Staphylococcus aureus/drug effects ; Trypanosoma brucei brucei/drug effects
Czasopismo naukowe
Tytuł :
Design, synthesis and inhibitory activity of novel 2, 3-dihydroquinolin-4(1H)-one derivatives as potential succinate dehydrogenase inhibitors.
Autorzy :
Cheng W; School of Science, Xihua University, Chengdu, 610039, PR China.
Yan Y; School of Science, Xihua University, Chengdu, 610039, PR China.
Xiao T; School of Science, Xihua University, Chengdu, 610039, PR China.
Zhang G; School of Science, Xihua University, Chengdu, 610039, PR China.
Zhang T; School of Science, Xihua University, Chengdu, 610039, PR China.
Lu T; School of Science, Xihua University, Chengdu, 610039, PR China.
Jiang W; School of Science, Xihua University, Chengdu, 610039, PR China.
Wang J; School of Science, Xihua University, Chengdu, 610039, PR China.
Tang X; School of Science, Xihua University, Chengdu, 610039, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 15; Vol. 214, pp. 113246. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antifungal Agents/*pharmacology
Quinolones/*pharmacology
Succinate Dehydrogenase/*antagonists & inhibitors
Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Ascomycota/drug effects ; Bipolaris/drug effects ; Botrytis/drug effects ; Botrytis/enzymology ; Dose-Response Relationship, Drug ; Ligands ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Rhizoctonia/drug effects ; Structure-Activity Relationship ; Succinate Dehydrogenase/metabolism ; Thermodynamics
SCR Organism :
Bipolaris maydis; Botrytis cinerea; Rhizoctonia solani; Sclerotinia sclerotiorum
Czasopismo naukowe
Tytuł :
Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
Autorzy :
Zhang W; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Liu LL; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Lun S; Center for Tuberculosis Research, Department of Medicine, Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD, 21231-1044, United States.
Wang SS; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Xiao S; Center for Tuberculosis Research, Department of Medicine, Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD, 21231-1044, United States.
Gunosewoyo H; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, Perth, WA, 6102, Australia.
Yang F; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Tang J; Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Bishai WR; Center for Tuberculosis Research, Department of Medicine, Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD, 21231-1044, United States. Electronic address: .
Yu LF; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113202. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antitubercular Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Mycobacterium tuberculosis/*drug effects
Polyketide Synthases/*antagonists & inhibitors
Quinolones/*pharmacology
Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Bacterial Proteins/metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/growth & development ; Polyketide Synthases/metabolism ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Modulators of CFTR. Updates on clinical development and future directions.
Autorzy :
Bardin E; Institut Necker Enfants Malades. INSERM U1151, Paris, France.
Pastor A; LCBPT, UMR CNRS 8601, Paris, France; Université de Paris, Paris, France.
Semeraro M; Centre d'Investigation Clinique, Unité de Recherche Clinique-CIC P1419, Hôpital Necker Enfants Malades, Université de Paris, Paris, France.
Golec A; Institut Necker Enfants Malades. INSERM U1151, Paris, France.
Hayes K; Clinical Trial Network, European Cystic Fibrosis Society, Belfast, Ireland.
Chevalier B; Institut Necker Enfants Malades. INSERM U1151, Paris, France.
Berhal F; LCBPT, UMR CNRS 8601, Paris, France; Université de Paris, Paris, France.
Prestat G; LCBPT, UMR CNRS 8601, Paris, France; Université de Paris, Paris, France.
Hinzpeter A; Institut Necker Enfants Malades. INSERM U1151, Paris, France.
Gravier-Pelletier C; LCBPT, UMR CNRS 8601, Paris, France; Université de Paris, Paris, France.
Pranke I; Institut Necker Enfants Malades. INSERM U1151, Paris, France.
Sermet-Gaudelus I; Institut Necker Enfants Malades. INSERM U1151, Paris, France; Université de Paris, Paris, France; Clinical Trial Network, European Cystic Fibrosis Society, Belfast, Ireland; Centre de Référence Maladies Rares, Mucoviscidose et Maladies de CFTR, Hôpital Necker Enfants Malades, Paris, France; European Respiratory Network Lung, Paris, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113195. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Development*
Aminophenols/*pharmacology
Aminopyridines/*pharmacology
Benzodioxoles/*pharmacology
Cystic Fibrosis/*drug therapy
Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism
Indoles/*pharmacology
Quinolones/*pharmacology
Aminophenols/chemical synthesis ; Aminophenols/chemistry ; Aminopyridines/chemical synthesis ; Benzodioxoles/chemical synthesis ; Clinical Trials as Topic ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Indoles/chemical synthesis ; Quinolones/chemical synthesis ; Quinolones/chemistry
Czasopismo naukowe
Tytuł :
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.
Autorzy :
Relitti N; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Chemi G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Brindisi M; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Brogi S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Schmidtkunz K; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Saccoccia F; Institute of Biochemistry and Cell Biology, CNR, Campus A. Buzzati-Traverso. Via E. Ramarini 32, 00015, Monterotondo, Rome, Italy.
Ruberti G; Institute of Biochemistry and Cell Biology, CNR, Campus A. Buzzati-Traverso. Via E. Ramarini 32, 00015, Monterotondo, Rome, Italy.
Ulivieri C; Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Vanni F; Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Sarno F; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138, Naples, Italy.
Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138, Naples, Italy.
Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 112998. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Histone Deacetylase 6/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*pharmacology
Quinolones/*pharmacology
Animals ; Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Histone Deacetylase 6/metabolism ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Mice ; Models, Molecular ; Molecular Structure ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Recombinant Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Copper(I)-Catalyzed Nitrile-Addition/ N -Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6 H -indolo[3,2- c ]quinolin-6-ones as Potent Topoisomerase-I Inhibitors.
Autorzy :
Hsueh WY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lee YE; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Huang MS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lai CH; Department of Applied Chemistry, Chung Shan Medical University, Taichung 40201, Taiwan.
Gao YS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lin JC; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chen YF; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chang CL; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chou SY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chen SF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lu YY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chang LH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lin SF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lin YH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Hsu PC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Wei WY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Huang YC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Kao YF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Teng LW; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Liu HH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chen YC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Yuan TT; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chan YW; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang PH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chao YT; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang SY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Jian BH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang HY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Yang SC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lo TH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang GR; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Wang SY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lin HS; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chuang SH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Huang JJ; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Feb 11; Vol. 64 (3), pp. 1435-1453. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Copper/*chemistry
Nitriles/*chemistry
Quinolones/*chemical synthesis
Quinolones/*pharmacology
Topoisomerase I Inhibitors/*chemical synthesis
Topoisomerase I Inhibitors/*pharmacology
Animals ; Catalysis ; DNA Topoisomerases, Type I/chemistry ; Drug Design ; Drug Screening Assays, Antitumor ; Female ; Humans ; Male ; Mice ; Mice, Nude ; Models, Molecular ; Molecular Docking Simulation ; Quinolones/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Topoisomerase I Inhibitors/pharmacokinetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters.
Autorzy :
Ben Taleb A; Faculty of Engineering, Department of Bio and Nanotechnology, Istanbul University-Cerrahpasa, Istanbul, Turkey. .
Karakuş S; Faculty of Engineering, Department of Bio and Nanotechnology, Istanbul University-Cerrahpasa, Istanbul, Turkey.; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Tan E; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Ilgar M; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Kutlu Ö; Nanotechnology Research andApplication Center (SUNUM),Sabanci University, Istanbul, Turkey.
Gözüaçık D; Koç University Hospital, School of Medicine and Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Zeytinburnu 34010, Istanbul, Turkey.
Kutlu HM; Department of Biology, Faculty of Science, Eskişehir Technical University, Eskişehir, Turkey.
Kilislioğlu A; Faculty of Engineering, Department of Bio and Nanotechnology, Istanbul University-Cerrahpasa, Istanbul, Turkey.; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2207, pp. 199-220.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacokinetics
Antineoplastic Agents*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Neoplasms*/drug therapy
Neoplasms*/metabolism
Neoplasms*/pathology
Quinolones*/chemistry
Quinolones*/pharmacokinetics
Quinolones*/pharmacology
Polyethylene Glycols/*chemistry
Resins, Plant/*chemistry
HeLa Cells ; Humans
Czasopismo naukowe
Tytuł :
Combined toxicity characteristics and regulation of residual quinolone antibiotics in water environment.
Autorzy :
Ren Z; College of Forestry, Northeast Forestry University, No. 26 Hexing Road, Harbin, 150040, China. Electronic address: .
Xu H; Appraisal Center for Environmental & Engineering Ministry of Ecology and Environment, No. 28 Beiyuan Road, Beijing, 100012, China. Electronic address: .
Wang Y; College of Forestry, Northeast Forestry University, No. 26 Hexing Road, Harbin, 150040, China. Electronic address: .
Li Y; College of Forestry, Northeast Forestry University, No. 26 Hexing Road, Harbin, 150040, China. Electronic address: .
Han S; College of Forestry, Northeast Forestry University, No. 26 Hexing Road, Harbin, 150040, China. Electronic address: .
Ren J; Jilin Branch of China Kunlun Contracting Engineering Corporation, No. 888 Binjiangxi Road, Jilin, 132013, China. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Jan; Vol. 263, pp. 128301. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents*/analysis
Anti-Bacterial Agents*/toxicity
Quinolones*/toxicity
Ciprofloxacin ; Molecular Docking Simulation ; Water
Czasopismo naukowe
Tytuł :
Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in central Iran.
Autorzy :
Abbasi E; Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran.
Ghaznavi-Rad E; Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran. .; Molecular and Medicine Research Center, Faculty of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran. .; Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Arak University of Medical Sciences, Arak, Iran. .
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Źródło :
BMC gastroenterology [BMC Gastroenterol] 2021 Mar 30; Vol. 21 (1), pp. 140. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Quinolones*/pharmacology
Anti-Bacterial Agents/pharmacology ; Child ; Diarrhea/drug therapy ; Diarrhea/epidemiology ; Humans ; Integrons ; Iran/epidemiology ; Microbial Sensitivity Tests ; Salmonella/genetics
Czasopismo naukowe
Tytuł :
[Cystic fibrosis prognosis in Europa : chronicle of an announced dilemma].
Autorzy :
Lebecque P; Unité de Pneumologie pédiatrique et Mucoviscidose, MontLégia, Liège, Belgique.
Thimmesch M; Unité de Pneumologie pédiatrique et Mucoviscidose, MontLégia, Liège, Belgique.
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Transliterated Title :
Modulateurs et pronostic de la mucoviscidose en Europe : chronique d’un dilemme annoncé.
Źródło :
Revue medicale de Liege [Rev Med Liege] 2021 Mar; Vol. 76 (3), pp. 202-207.
Typ publikacji :
Journal Article
MeSH Terms :
Cystic Fibrosis*/diagnosis
Cystic Fibrosis*/therapy
Quinolones*
Aminophenols ; Aminopyridines ; Benzodioxoles ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Europe ; Humans ; Mutation ; Prognosis
Czasopismo naukowe
Tytuł :
Rebamipide potentially mitigates methotrexate-induced nephrotoxicity via inhibition of oxidative stress and inflammation: A molecular and histochemical study.
Autorzy :
Elmansy RA; Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.; Anatomy Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Seleem HS; Histology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.; Histology Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Mahmoud AR; Anatomy Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
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Źródło :
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2021 Mar; Vol. 304 (3), pp. 647-661. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alanine/*analogs & derivatives
Antioxidants/*therapeutic use
Inflammation/*metabolism
Kidney/*drug effects
Kidney Diseases/*drug therapy
Methotrexate/*adverse effects
Oxidative Stress/*drug effects
Quinolones/*pharmacology
Alanine/pharmacology ; Alanine/therapeutic use ; Animals ; Antimetabolites, Antineoplastic/adverse effects ; Antioxidants/pharmacology ; Kidney/metabolism ; Kidney Diseases/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; Quinolones/therapeutic use ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Ivacaftor in Infants Aged 4 to <12 Months with Cystic Fibrosis and a Gating Mutation. Results of a Two-Part Phase 3 Clinical Trial.
Autorzy :
Davies JC; National Heart & Lung Institute, Imperial College London and Royal Brompton Hospital, London, United Kingdom.
Wainwright CE; Queensland Children's Hospital, University of Queensland, Brisbane, Queensland, Australia.
Sawicki GS; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Higgins MN; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts; and.
Campbell D; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts; and.
Harris C; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts; and.
Panorchan P; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts; and.
Haseltine E; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts; and.
Tian S; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts; and.
Rosenfeld M; Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Mar 01; Vol. 203 (5), pp. 585-593.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminophenols/*therapeutic use
Chloride Channel Agonists/*therapeutic use
Cystic Fibrosis/*drug therapy
Quinolones/*therapeutic use
Aminophenols/pharmacokinetics ; Chloride Channel Agonists/pharmacokinetics ; Chlorides/metabolism ; Cough/epidemiology ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Exocrine Pancreatic Insufficiency/metabolism ; Female ; Fever/epidemiology ; Genotype ; Humans ; Infant ; Ion Channel Gating/genetics ; Male ; Mutation ; Otitis Media/epidemiology ; Pancreatic Elastase/metabolism ; Quinolones/pharmacokinetics ; Respiratory Tract Infections/epidemiology ; Rhinorrhea/epidemiology ; Sweat/metabolism ; Treatment Outcome ; Vomiting/epidemiology
Czasopismo naukowe
Tytuł :
Quinolone immediate hypersensitivity due to topical ophthalmic preparations: a case report and review of literature.
Autorzy :
Ajima S; Department of Dermatology, Iwata City Hospital, Iwata, Japan.
Sano Y; Department of Dermatology, Iwata City Hospital, Iwata, Japan.
Hashizume H; Department of Dermatology, Iwata City Hospital, Iwata, Japan.
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Źródło :
The Journal of dermatology [J Dermatol] 2021 Mar; Vol. 48 (3), pp. 389-391. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Drug Hypersensitivity*/diagnosis
Drug Hypersensitivity*/etiology
Hypersensitivity, Immediate*/chemically induced
Hypersensitivity, Immediate*/diagnosis
Quinolones*/adverse effects
Adult ; Female ; Humans ; Skin Tests ; Young Adult
Czasopismo naukowe
Tytuł :
Synthesis of 3,3'-methylenebis(4-hydroxyquinolin-2(1H)-ones) of prospective anti-COVID-19 drugs.
Autorzy :
Aly AA; Department of Chemistry, Faculty of Science, Minia University, Minia, 61519, Egypt. .
Hassan AA; Department of Chemistry, Faculty of Science, Minia University, Minia, 61519, Egypt.
Mohamed AH; Department of Chemistry, Faculty of Science, Minia University, Minia, 61519, Egypt.
Osman EM; Department of Chemistry, Faculty of Science, Minia University, Minia, 61519, Egypt.
Bräse S; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany.; Institute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Nieger M; Department of Chemistry, University of Helsinki, A. I. Virtasenaukio I, P.O. Box 55, 00014, Helsinki, Finland.
Ibrahim MAA; Department of Chemistry, Faculty of Science, Minia University, Minia, 61519, Egypt.
Mostafa SM; Department of Chemistry, Faculty of Science, Minia University, Minia, 61519, Egypt.
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Źródło :
Molecular diversity [Mol Divers] 2021 Feb; Vol. 25 (1), pp. 461-471. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemical synthesis
COVID-19/*drug therapy
Protease Inhibitors/*chemical synthesis
Quinolones/*chemical synthesis
SARS-CoV-2/*drug effects
Antiviral Agents/pharmacology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Darunavir/pharmacology ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation/methods ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacology ; Quinolones/pharmacology ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
Polypharmacological drug actions of recently FDA approved antibiotics.
Autorzy :
Wetzel C; Mount Marty University, 1105 W. 8th Street, Yankton, SD, 57078, USA.
Lonneman M; Mount Marty University, 1105 W. 8th Street, Yankton, SD, 57078, USA.
Wu C; Mount Marty University, 1105 W. 8th Street, Yankton, SD, 57078, USA. Electronic address: cwu@@mountmarty.edu.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 01; Vol. 209, pp. 112931. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Lipoglycopeptides/*chemistry
Quinolones/*chemistry
Small Molecule Libraries/*chemistry
beta-Lactams/*chemistry
Anti-Bacterial Agents/pharmacology ; Drug Approval ; Drug Evaluation, Preclinical ; Drug Resistance, Microbial ; Humans ; Lipoglycopeptides/pharmacology ; Pharmaceutical Preparations ; Polypharmacology ; Quinolones/pharmacology ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; United States ; United States Food and Drug Administration ; beta-Lactams/pharmacology
Czasopismo naukowe

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