Temat: "Quinones" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Dihydrotanshinone I exhibits antitumor effects via β-catenin downregulation in papillary thyroid cancer cell lines.
Autorzy:: Molteni E; Department of Medicine, University of Udine, 33100, Udine, Italy.
Baldan F; Department of Medicine, University of Udine, 33100, Udine, Italy. .
Damante G; Department of Medicine, University of Udine, 33100, Udine, Italy.; Institute of Medical Genetics, Academic Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy.
Allegri L; Department of Medicine, University of Udine, 33100, Udine, Italy.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Apr 03; Vol. 14 (1), pp. 7853. Date of Electronic Publication: 2024 Apr 03.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Papillary*/drug therapy
Carcinoma, Papillary*/genetics
Carcinoma, Papillary*/metabolism
Thyroid Neoplasms*/drug therapy
Thyroid Neoplasms*/genetics
Thyroid Neoplasms*/metabolism
Furans*
Phenanthrenes*
Quinones*
Humans ; Thyroid Cancer, Papillary/drug therapy ; Thyroid Cancer, Papillary/pathology ; beta Catenin/genetics ; beta Catenin/metabolism ; Down-Regulation ; Cell Line, Tumor ; Wnt Signaling Pathway/genetics ; Cell Proliferation/physiology ; Cell Movement/genetics

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Skocz do pozycji: 2.

Tytuł:: Streptomyces iakyrus TA 36 as First-Reported Source of Quinone Antibiotic γ-Rubromycin.
Autorzy:: Charousová I; Clinical Microbiology Laboratory, Unilabs Slovensko, s.r.o., J. Bellu 66, SK-03495 Likavka, Slovakia.; Institute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Nitra, Tr. A. Hlinku 2, SK-94976 Nitra, Slovakia.
Hlebová M; Department of Biology, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava, Slovakia.
Hleba L; Institute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Nitra, Tr. A. Hlinku 2, SK-94976 Nitra, Slovakia.
Medo J; Institute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Nitra, Tr. A. Hlinku 2, SK-94976 Nitra, Slovakia.
Wink J; Microbial Strain Collection Group, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Aug 09; Vol. 28 (16). Date of Electronic Publication: 2023 Aug 09.
Typ publikacji:: Journal Article
MeSH Terms:: Quinones*/pharmacology
Streptomyces*
Phylogeny ; RNA, Ribosomal, 16S/genetics ; Anti-Bacterial Agents/pharmacology
SCR Organism:: Streptomyces iakyrus

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Skocz do pozycji: 3.

Tytuł:: It Takes Two to Tango, Part II: Synthesis of A-Ring Functionalised Quinones Containing Two Redox-Active Centres with Antitumour Activities.
Autorzy:: Oliveira JC; Institute of Exact Sciences, Department of Chemistry, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 31270-901, Brazil.
de Carvalho RL; Institute of Exact Sciences, Department of Chemistry, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 31270-901, Brazil.
Sampaio HGS; Institute of Exact Sciences, Department of Chemistry, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 31270-901, Brazil.
Honorato J; São Carlos Institute of Physics, Physics and Interdisciplinary Sciences Department, Universidade de São Paulo, USP, São Carlos 13560-970, Brazil.
Ellena JA; São Carlos Institute of Physics, Physics and Interdisciplinary Sciences Department, Universidade de São Paulo, USP, São Carlos 13560-970, Brazil.
Martins FT; Chemistry Institute, Universidade Federal de Goiás, UFG, Goiânia 74690-900, Brazil.
Pereira JVM; Department of Physiology and Pharmacology, Universidade Federal de Ceará, UFC, Fortaleza 60430-270, Brazil.
Costa PMS; Department of Physiology and Pharmacology, Universidade Federal de Ceará, UFC, Fortaleza 60430-270, Brazil.
Pessoa C; Department of Physiology and Pharmacology, Universidade Federal de Ceará, UFC, Fortaleza 60430-270, Brazil.
Ferreira RS; Biological Sciences Institute, Biochemistry and Immunology Department, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 31270-901, Brazil.
Araújo MH; Institute of Exact Sciences, Department of Chemistry, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 31270-901, Brazil.
Jacob C; Division of Bioorganic Chemistry, School of Pharmacy, University of Saarland, 66123 Saarbruecken, Germany.
da Silva Júnior EN; Institute of Exact Sciences, Department of Chemistry, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 31270-901, Brazil.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 27; Vol. 28 (5). Date of Electronic Publication: 2023 Feb 27.
Typ publikacji:: Journal Article
MeSH Terms:: Quinones*/chemistry
Naphthoquinones*/chemistry
Animals ; Mice ; Benzoquinones ; Oxidation-Reduction ; Click Chemistry ; Cycloaddition Reaction

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Skocz do pozycji: 4.

Tytuł:: Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure.
Autorzy:: Stanley S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Wang X; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Liu Q; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Kwon YY; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Frey AM; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Hicks ND; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Vickers AJ; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Hui S; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Fortune SM; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2024 Feb 29; Vol. 20 (2), pp. e1012050. Date of Electronic Publication: 2024 Feb 29 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Mycobacterium tuberculosis*/metabolism
Humans ; L-Lactate Dehydrogenase ; Lactic Acid/metabolism ; Pyruvates/metabolism ; Quinones/metabolism ; Phosphates/metabolism

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Skocz do pozycji: 5.

Tytuł:: Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core.
Autorzy:: Ţînţaş ML; INSA Rouen Normandie, Univ. Rouen Normandie, CNRS UMR 6014 COBRA, FR 3038, F-76000 Rouen, France.
Peauger L; VFP Therapies, 15 rue François Couperin, 76000 Rouen, France.
Alix F; VFP Therapies, 15 rue François Couperin, 76000 Rouen, France.
Papamicaël C; INSA Rouen Normandie, Univ. Rouen Normandie, CNRS UMR 6014 COBRA, FR 3038, F-76000 Rouen, France.
Besson T; INSA Rouen Normandie, Univ. Rouen Normandie, CNRS UMR 6014 COBRA, FR 3038, F-76000 Rouen, France.
Sopková-de Oliveira Santos J; UNICAEN, CERMN (Centre d'Etudes et de Recherche sur le Médicament de Normandie), Normandie Univ., Bd Becquerel, F-14032 Caen, France.
Gembus V; VFP Therapies, 15 rue François Couperin, 76000 Rouen, France.
Levacher V; INSA Rouen Normandie, Univ. Rouen Normandie, CNRS UMR 6014 COBRA, FR 3038, F-76000 Rouen, France.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 21; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Kinase Inhibitors*/chemistry
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/therapeutic use
Quinones*/chemistry
Quinones*/pharmacology
Quinones*/therapeutic use
Humans ; Alzheimer Disease/drug therapy ; Down Syndrome/drug therapy ; Glycogen Synthase Kinase 3/metabolism ; Molecular Docking Simulation ; Phosphorylation ; Dyrk Kinases

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Skocz do pozycji: 6.

Tytuł:: Quinones as an Efficient Molecular Scaffold in the Antibacterial/Antifungal or Antitumoral Arsenal.
Autorzy:: Dahlem Junior MA; Aix-Marseille Université, CNRS, CINaM, 13009 Marseille, France.
Nguema Edzang RW; Aix-Marseille Université, CNRS, CINaM, 13009 Marseille, France.; Department of Chemistry and Biochemistry, University of Health Science (USS), Libreville 18231, Gabon.
Catto AL; Aix-Marseille Université, CNRS, CINaM, 13009 Marseille, France.; Center for Exact and Technological Sciences (CETEC), University of Taquari Valley, Lajeado 95914-014, RS, Brazil.
Raimundo JM; Aix-Marseille Université, CNRS, CINaM, 13009 Marseille, France.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 15; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antifungal Agents*
Quinones*/pharmacology
Anti-Bacterial Agents/pharmacology ; Biofilms

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Skocz do pozycji: 7.

Tytuł:: A 3D-Predicted Structure of the Amine Oxidase Domain of Lysyl Oxidase-Like 2.
Autorzy:: Meier AA; Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
Kuczera K; Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.; Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
Mure M; Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 02; Vol. 23 (21). Date of Electronic Publication: 2022 Nov 02.
Typ publikacji:: Journal Article
MeSH Terms:: Protein-Lysine 6-Oxidase*/chemistry
Quinones*/chemistry
Models, Molecular ; Monoamine Oxidase ; Amines ; Amino Acid Oxidoreductases/chemistry

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Skocz do pozycji: 8.

Tytuł:: Construction of C-N Atropisomers by Aminocatalytic Enantioselective Addition of Indole-2-carboxaldehydes to o-Quinone Derivatives.
Autorzy:: Corti V; Department of Chemistry, Aarhus University, Aarhus, 8000 Aarhus C, Denmark.
Thøgersen MK; Department of Chemistry, Aarhus University, Aarhus, 8000 Aarhus C, Denmark.
Enemaerke VJ; Department of Chemistry, Aarhus University, Aarhus, 8000 Aarhus C, Denmark.
Rezayee NM; Department of Chemistry, Aarhus University, Aarhus, 8000 Aarhus C, Denmark.
Barløse CL; Department of Chemistry, Aarhus University, Aarhus, 8000 Aarhus C, Denmark.
Anker Jørgensen K; Department of Chemistry, Aarhus University, Aarhus, 8000 Aarhus C, Denmark.; Pokaż więcej
Źródło:: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Oct 26; Vol. 28 (60), pp. e202202395. Date of Electronic Publication: 2022 Aug 23.
Typ publikacji:: Journal Article
MeSH Terms:: Indoles*/chemistry
Quinones*
Stereoisomerism ; Amines/chemistry ; Complex Mixtures

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Skocz do pozycji: 9.

Tytuł:: Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330.
Autorzy:: Silva LL; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indiana, Indianapolis, USA.
Stratford RE; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indiana, Indianapolis, USA.
Messmann R; Apexian Pharmaceuticals, Indianapolis, Indiana, USA.
Kelley MR; Departments of Biochemistry and Molecular Biology, and Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Quinney SK; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indiana, Indianapolis, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Jan; Vol. 13 (1), pp. 106-117. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:: Journal Article
MeSH Terms:: Hydroquinones*
Neoplasms*
Humans ; Male ; Administration, Oral ; Angiogenesis Inhibitors ; Quinones

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Skocz do pozycji: 10.

Tytuł:: Oxidation of Mesalamine under Phenoloxidase- or Peroxidase-like Enzyme Catalysis.
Autorzy:: El Zein R; Department of Chemistry and Center CERMO-FC, Université du Québec à Montréal, Downtown Branch, P.O. Box 8888, Montréal, QC H3C 3P8, Canada.
Ispas-Szabo P; Department of Chemistry and Center CERMO-FC, Université du Québec à Montréal, Downtown Branch, P.O. Box 8888, Montréal, QC H3C 3P8, Canada.
Jafari M; Department of Chemistry and Center CERMO-FC, Université du Québec à Montréal, Downtown Branch, P.O. Box 8888, Montréal, QC H3C 3P8, Canada.
Siaj M; Department of Chemistry and Center CERMO-FC, Université du Québec à Montréal, Downtown Branch, P.O. Box 8888, Montréal, QC H3C 3P8, Canada.
Mateescu MA; Department of Chemistry and Center CERMO-FC, Université du Québec à Montréal, Downtown Branch, P.O. Box 8888, Montréal, QC H3C 3P8, Canada.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 15; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:: Journal Article
MeSH Terms:: Mesalamine*/chemistry
Colitis, Ulcerative*/drug therapy
Humans ; Monophenol Monooxygenase ; Hydroquinones ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Peroxidase ; Oxidation-Reduction ; Peroxidases ; Quinones/therapeutic use ; Catalysis ; Imines

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Skocz do pozycji: 11.

Tytuł:: Poncirus trifoliata Aqueous Extract Protects Cardiomyocytes against Doxorubicin-Induced Toxicity through Upregulation of NAD(P)H Dehydrogenase Quinone Acceptor Oxidoreductase 1.
Autorzy:: Kim MS; Korea Food Research Institute, Wanju 55365, Republic of Korea.
Choi HK; Korea Food Research Institute, Wanju 55365, Republic of Korea.
Park SH; Korea Food Research Institute, Wanju 55365, Republic of Korea.
Lee JI; Korea Food Research Institute, Wanju 55365, Republic of Korea.
Lee J; Korea Food Research Institute, Wanju 55365, Republic of Korea.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 14; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:: Journal Article
MeSH Terms:: Myocytes, Cardiac*
Poncirus*/metabolism
Rats ; Mice ; Humans ; Animals ; NAD/metabolism ; Up-Regulation ; Oxidative Stress ; Mice, Inbred C57BL ; Doxorubicin/toxicity ; Cardiotoxicity/drug therapy ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Oxidoreductases/metabolism ; Quinones/pharmacology

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Skocz do pozycji: 12.

Tytuł:: Biotinylated Quinone as a Chemiluminescence Sensor for Biotin-Avidin Interaction and Biotin Detection Application.
Autorzy:: Kaladari F; Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
El-Maghrabey M; Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Kawazato M; Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
Kishikawa N; Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
Kuroda N; Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.; Pokaż więcej
Źródło:: Sensors (Basel, Switzerland) [Sensors (Basel)] 2023 Dec 04; Vol. 23 (23). Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:: Journal Article
MeSH Terms:: Avidin*
Naphthoquinones*
Animals ; Biotin ; Luminescence ; Quinones ; Vitamins/analysis ; Mammals/metabolism

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Skocz do pozycji: 13.

Tytuł:: Oxidation of flavonoids by tyrosinase and by o -quinones-comment on "Flavonoids as tyrosinase inhibitors in in silico and in vitro models: basic framework of SAR using a statistical modelling approach" published by K. Jakimiuk, S. Sari, R. Milewski, C.T. Supuran, D. Şöhretoğlu, and M. Tomczyk (J Enzyme Inhib Med Chem 2022;37:427-436).
Autorzy:: Wojtasek H; Institute of Chemistry, Opole University, Opole, Poland.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2269611. Date of Electronic Publication: 2023 Oct 16.
Typ publikacji:: Journal Article; Comment
MeSH Terms:: Monophenol Monooxygenase*
Flavonoids*/pharmacology
Quinones ; Oxidation-Reduction ; Enzyme Inhibitors/pharmacology

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Skocz do pozycji: 14.

Tytuł:: Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury.
Autorzy:: Hu E; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Li T; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Li Z; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Su H; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Yan Q; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Wang L; Department of Respiratory Diseases, Xiangxiang People's Hospital, Xiangxiang, PR China.
Li H; Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, PR China.
Zhang W; The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, PR China.
Tang T; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Wang Y; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; Pokaż więcej
Źródło:: Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 1054-1064.
Typ publikacji:: Journal Article
MeSH Terms:: Brain Injuries, Traumatic*/drug therapy
Chalcone*/pharmacology
Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Brain-Derived Neurotrophic Factor ; Axons ; Nerve Regeneration ; Quinones/pharmacology ; Metabolomics

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Skocz do pozycji: 15.

Tytuł:: Phase 1 Study to Investigate the Safety, Tolerability, and Pharmacokinetics of EPI-589 in Healthy Participants.
Autorzy:: Noda N; Clinical Research, Drug Development Division, Sumitomo Pharma Co., Ltd., Osaka, Japan.
Hamatani T; Clinical Research, Drug Development Division, Sumitomo Pharma Co., Ltd., Osaka, Japan.
Shibue Y; Clinical Research, Drug Development Division, Sumitomo Pharma Co., Ltd., Osaka, Japan.
Takagaki T; Clinical Research, Drug Development Division, Sumitomo Pharma Co., Ltd., Osaka, Japan.
Kitamura A; Clinical Research, Drug Development Division, Sumitomo Pharma Co., Ltd., Osaka, Japan.
Haranaka M; SOUSEIKAI Hakata Clinic, Fukuoka, Japan.
Ogama Y; SOUSEIKAI Sumida Hospital, Tokyo, Japan.
Kakuyama H; Clinical Research, Drug Development Division, Sumitomo Pharma Co., Ltd., Osaka, Japan.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Oct; Vol. 11 (10), pp. 1136-1146. Date of Electronic Publication: 2022 Aug 21.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Oxidoreductases*
Quinones*
Administration, Oral ; Area Under Curve ; Drug Administration Schedule ; Healthy Volunteers ; Humans

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Skocz do pozycji: 16.

Tytuł:: Biosensing firefly luciferin synthesis in bacteria reveals a cysteine-dependent quinone detoxification route in Coleoptera.
Autorzy:: de Souza DR; Graduate Program of Biotechnology and Environmental Monitoring, Federal University of São Carlos, Sorocaba, Brazil.
Silva JR; Departament of Physics, Chemistry and Mathematics, Federal University of São Carlos, Sorocaba, Brazil.
Moreira A; Departament of Physics, Chemistry and Mathematics, Federal University of São Carlos, Sorocaba, Brazil.
Viviani VR; Graduate Program of Biotechnology and Environmental Monitoring, Federal University of São Carlos, Sorocaba, Brazil. .; Departament of Physics, Chemistry and Mathematics, Federal University of São Carlos, Sorocaba, Brazil. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Aug 31; Vol. 12 (1), pp. 14815. Date of Electronic Publication: 2022 Aug 31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Coleoptera*/metabolism
Firefly Luciferin*/metabolism
Luciferases, Firefly*/metabolism
Quinones*/metabolism
Animals ; Cysteine/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fireflies/genetics ; Luciferases/genetics ; Luciferases/metabolism ; Luciferins ; Luminescent Measurements ; Saccharomycetales/metabolism
SCR Organism:: Komagataella pastoris

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Skocz do pozycji: 17.

Tytuł:: Hydroxysafflor yellow A protects against ulcerative colitis via suppressing TLR4/NF-κB signaling pathway.
Autorzy:: Feng Z; Department of Anorectal, Jiangxi Province Hospital of Integrated Chinese Western Medicine, Nanchang, China.
Zhou P; Department of Anorectal, Jiangxi Province Hospital of Integrated Chinese Western Medicine, Nanchang, China.
Wu X; Department of Anorectal, Jiangxi Province Hospital of Integrated Chinese Western Medicine, Nanchang, China.
Zhang J; Department of Anorectal, Jiangxi Province Hospital of Integrated Chinese Western Medicine, Nanchang, China.
Zhang M; Department of Anorectal, Jiangxi Province Hospital of Integrated Chinese Western Medicine, Nanchang, China.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2022 Jun; Vol. 99 (6), pp. 897-907. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji:: Journal Article
MeSH Terms:: Chalcone*/analogs & derivatives
Chalcone*/pharmacology
Colitis, Ulcerative*/chemically induced
Colitis, Ulcerative*/drug therapy
Colitis, Ulcerative*/metabolism
NF-kappa B*/antagonists & inhibitors
NF-kappa B*/metabolism
Quinones*/pharmacology
Toll-Like Receptor 4*/antagonists & inhibitors
Toll-Like Receptor 4*/metabolism
Animals ; Body Weight/drug effects ; Colon/metabolism ; Colon/pathology ; Disease Models, Animal ; Lipopolysaccharides/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects

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Skocz do pozycji: 18.

Tytuł:: Unraveling the Antioxidant Activity of 2R , 3R -dihydroquercetin.
Autorzy:: Xu Y; College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.
Li Z; School of Pharmacy, Chengdu University, 2025 Chengluo Avenue, Chengdu 610106, China.
Wang Y; Department of Pharmacology and Personalized Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands.
Li C; Department of Pharmacology and Personalized Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands.
Zhang M; College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.
Chen H; College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.
Chen W; College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.
Zhong Q; College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.
Pei J; College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.
Chen W; College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.
Haenen GRMM; Department of Pharmacology and Personalized Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands.
Moalin M; Research Centre Material Sciences, Zuyd University of Applied Science, 6400 AN Heerlen, The Netherlands.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 18; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants*/pharmacology
Quercetin*/pharmacology
Hydrogen Peroxide ; Ascorbic Acid ; Glutathione ; Quinones

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Skocz do pozycji: 19.

Tytuł:: Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research.
Autorzy:: Zhang X; School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China.
Shen D; School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China.
Feng Y; School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China.
Li Y; Department of Pharmacy, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan 030012, China.
Liao H; Department of Pharmacy, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan 030012, China.; Pokaż więcej
Źródło:: Journal of immunology research [J Immunol Res] 2021 Dec 13; Vol. 2021, pp. 4560012. Date of Electronic Publication: 2021 Dec 13 (Print Publication: 2021).
Typ publikacji:: Journal Article; Review
MeSH Terms:: Research*
Chalcone/*analogs & derivatives
Hypoglycemic Agents/*pharmacology
Quinones/*pharmacology
Animals ; Apoptosis/drug effects ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Biomarkers ; Carthamus tinctorius ; Chalcone/chemistry ; Chalcone/pharmacology ; Chalcone/therapeutic use ; Clinical Studies as Topic ; Drug Administration Routes ; Drug Evaluation, Preclinical ; Drug Monitoring ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/therapeutic use ; Quinones/chemistry ; Quinones/therapeutic use ; Signal Transduction/drug effects

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Skocz do pozycji: 20.

Tytuł:: Differential Pattern of Cell Death and ROS Production in Human Airway Epithelial Cells Exposed to Quinones Combined with Heated-PM2.5 and/or Asian Sand Dust.
Autorzy:: Honda A; Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan.
Inoue KI; School of Nursing, University of Shizuoka, Shizuoka 422-8526, Japan.
Higashihara M; Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan.
Ichinose T; Graduate School of Global Environmental Studies, Kyoto University, Kyoto 615-8540, Japan.; Department of Health Science, Oita University of Nursing and Health Sciences, Oita 870-1201, Japan.
Ueda K; Department of Hygiene, Graduate School of Medicine, Hokkaido University, Hokkaido 060-8638, Japan.
Takano H; Graduate School of Global Environmental Studies, Kyoto University, Kyoto 615-8540, Japan.; Institute for International Academic Research, Kyoto University of Advanced Science, Kyoto 615-8577, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 23; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 23.
Typ publikacji:: Journal Article
MeSH Terms:: Dust*/analysis
Naphthoquinones*/pharmacology
Humans ; Quinones/metabolism ; Reactive Oxygen Species/metabolism ; Sand ; Particulate Matter/toxicity ; Epithelial Cells/metabolism ; Cell Death

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