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Tytuł :
Spirulina maxima Derived Pectin Nanoparticles Enhance the Immunomodulation, Stress Tolerance, and Wound Healing in Zebrafish.
Autorzy :
Rajapaksha DC; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Korea.
Edirisinghe SL; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Korea.
Nikapitiya C; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Korea.
Dananjaya S; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Korea.
Kwun HJ; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Korea.
Kim CH; Department of Biology, Chungnam National University, Yuseong-gu, Daejeon 34134, Korea.
Oh C; Jeju Marine Research Center, Korea Institute of Ocean Science and Technology (KIOST), Jeju Special Self-Governing Province 63349, Korea.; Department of Ocean Science, University of Science and Technology (UST), Jeju Special Self-Governing Province 63349, Korea.
Kang DH; Jeju Marine Research Center, Korea Institute of Ocean Science and Technology (KIOST), Jeju Special Self-Governing Province 63349, Korea.; Department of Ocean Science, University of Science and Technology (UST), Jeju Special Self-Governing Province 63349, Korea.
De Zoysa M; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Korea.
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Źródło :
Marine drugs [Mar Drugs] 2020 Nov 07; Vol. 18 (11). Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Nanoparticles*
Zebrafish*/embryology
Zebrafish*/genetics
Zebrafish*/immunology
Zebrafish*/microbiology
Immunologic Factors/*pharmacology
Oxidative Stress/*drug effects
Pectins/*pharmacology
RAW 264.7 Cells/*drug effects
Spirulina/*metabolism
Wound Healing/*drug effects
Aeromonas hydrophila/pathogenicity ; Animals ; Gene Expression Regulation ; Immunologic Factors/isolation & purification ; Mice ; Pectins/isolation & purification ; RAW 264.7 Cells/immunology ; RAW 264.7 Cells/metabolism ; Reactive Oxygen Species/metabolism ; Transcriptome ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cytotoxicity of bismuth nanoparticles in the murine macrophage cell line RAW 264.7.
Autorzy :
da Luz JZ; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal do Paraná, Curitiba, PR, CEP 81.531-990, Brazil. .
Machado TN; Laboratório Fotonanobio, Departamento Acadêmico de Física, Universidade Tecnológica Federal do Paraná, Curitiba, PR, CEP 80.230-901, Brazil.
Bezerra AG Jr; Laboratório Fotonanobio, Departamento Acadêmico de Física, Universidade Tecnológica Federal do Paraná, Curitiba, PR, CEP 80.230-901, Brazil.
de Oliveira Ribeiro CA; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal do Paraná, Curitiba, PR, CEP 81.531-990, Brazil.
Neto FF; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal do Paraná, Curitiba, PR, CEP 81.531-990, Brazil. .
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Źródło :
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2020 Oct 31; Vol. 31 (11), pp. 95. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Bismuth/*toxicity
Formazans/*chemistry
Macrophages/*drug effects
Metal Nanoparticles/*chemistry
RAW 264.7 Cells/*drug effects
Animals ; Bismuth/chemistry ; Cell Adhesion ; Cell Cycle ; Cell Proliferation ; Cell Survival ; DNA/drug effects ; DNA Damage/drug effects ; DNA Repair ; Lasers ; Macrophages/cytology ; Mice ; Phagocytosis ; RAW 264.7 Cells/cytology ; Reactive Oxygen Species ; Tetrazolium Salts/chemistry ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Cirsilineol attenuates LPS-induced inflammation in both in vivo and in vitro models via inhibiting TLR-4/NFkB/IKK signaling pathway.
Autorzy :
Ai M; Department of Emergency, First Affiliated Hospital of Air Force Military Medical University (Xijing Hospital), Xian, Shaanxi, China.
Lin S; Department of Intensive Care Unit, Huaian Hospital of Huai'an City, Huai'an, Jiangsu, China.
Zhang M; Department of Nursing, First Affiliated Hospital of Air Force Military Medical University (Xijing Hospital), Xian, Shaanxi, China.
Wu T; Pneumology Department, Jilin Medical College Affiliated Hospital, Jilin, China.
Yang N; Day Observation Ward, First Hospital of Jilin University, Changchun, Jilin, China.
Li Y; Department of Health Examination, Peace Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China.
Li L; Department of Emergency, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China.; Institute of Sepsis, Beijing University of Traditional Chinese Medicine, Beijing, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Aug; Vol. 35 (8), pp. e22799. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Lung Injury/*drug therapy
Flavones/*pharmacology
I-kappa B Kinase/*metabolism
Lipopolysaccharides/*toxicity
NF-kappa B/*metabolism
Signal Transduction/*drug effects
Toll-Like Receptor 4/*metabolism
Acute Lung Injury/chemically induced ; Acute Lung Injury/metabolism ; Animals ; Disease Models, Animal ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Male ; Mice ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Diterpenoids Isolated from Podocarpus macrophyllus Inhibited the Inflammatory Mediators in LPS-Induced HT-29 and RAW 264.7 Cells.
Autorzy :
Kim C; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon-si 57922, Jeonnam, Korea.; Jeonnam Institute of Natural Resources Research, Jangheung-gun 59338, Jeonnam, Korea.
Le D; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon-si 57922, Jeonnam, Korea.
Lee M; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon-si 57922, Jeonnam, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 17; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Tracheophyta*/chemistry
Anti-Inflammatory Agents/*pharmacology
Diterpenes/*pharmacology
Inflammation/*drug therapy
Inflammation Mediators/*antagonists & inhibitors
Lipopolysaccharides/*immunology
Animals ; Anti-Inflammatory Agents/isolation & purification ; Diterpenes/isolation & purification ; HT29 Cells ; Humans ; Inflammation/immunology ; Inflammation Mediators/immunology ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/immunology ; Mice ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Benzimidazole- and Imidazole-Fused Selenazolium and Selenazinium Selenocyanates: Ionic Organoselenium Compounds with Efficient Peroxide Scavenging Activities.
Autorzy :
Banerjee K; Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India.
Bhattacherjee D; Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India.; Centre for the Environment, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India.
Mahato SK; Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India.
Sufian A; Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India.
Bhabak KP; Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India.; Centre for the Environment, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India.
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Źródło :
Inorganic chemistry [Inorg Chem] 2021 Sep 06; Vol. 60 (17), pp. 12984-12999. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*pharmacology
Benzimidazoles/*pharmacology
Organoselenium Compounds/*pharmacology
Animals ; Antioxidants/chemical synthesis ; Benzimidazoles/chemical synthesis ; Cyanates/chemical synthesis ; Cyanates/pharmacology ; Cyclization ; Hydrogen Peroxide/chemistry ; Hydrogen Peroxide/metabolism ; Mice ; Organoselenium Compounds/chemical synthesis ; Oxidation-Reduction ; RAW 264.7 Cells ; Selenium Compounds/chemical synthesis ; Selenium Compounds/pharmacology
Czasopismo naukowe
Tytuł :
Structural characterization and immunomodulatory activity of intracellular polysaccharide from the mycelium of Paecilomyces cicadae TJJ1213.
Autorzy :
Tian J; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Zhang C; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Wang X; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Rui X; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Zhang Q; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Chen X; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Dong M; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Li W; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China. Electronic address: .
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Źródło :
Food research international (Ottawa, Ont.) [Food Res Int] 2021 Sep; Vol. 147, pp. 110515. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mycelium*
Polysaccharides*
Animals ; Cordyceps ; Immunity ; Mice ; RAW 264.7 Cells
SCR Organism :
Cordyceps cicadae
Czasopismo naukowe
Tytuł :
Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice.
Autorzy :
Cao X; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.
Tian Y; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha, China.
Nguyen V; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.
Zhang Y; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.; Department of General Surgery, Third Xiangya Hospital of Central South University, Changsha, China.
Gao C; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.
Yin R; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.
Carver W; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.; Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, SC, USA.
Fan D; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.; Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, SC, USA.
Albrecht H; Department of Internal Medicine, Prisma Health Medical Group, Columbia, SC, USA.; Department of Internal Medicine, School of Medicine, University of South Carolina, Columbia, SC, USA.
Cui T; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.; Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, SC, USA.
Tan W; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.; Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, SC, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21801.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Macrophages/*immunology
Pneumonia, Viral/*immunology
Pneumonia, Viral/*pathology
Spike Glycoprotein, Coronavirus/*immunology
Acute Disease ; Alveolar Epithelial Cells/virology ; Animals ; B7-1 Antigen ; Cell Line ; Inflammation Mediators ; Interleukin-10 ; Interleukin-6 ; Lentivirus/genetics ; Lentivirus/isolation & purification ; Lentivirus/metabolism ; Lung/immunology ; Lung/pathology ; Lung/virology ; Macrophages/virology ; Male ; Membrane Glycoproteins ; Mice ; Mice, Inbred C57BL ; PPAR gamma ; RAW 264.7 Cells ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Envelope Proteins
Czasopismo naukowe
Tytuł :
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury.
Autorzy :
Pan XY; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.; The key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.; Institute for Liver Diseases of Anhui Medical University, Hefei, China.
Wang L; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.; The key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.; Institute for Liver Diseases of Anhui Medical University, Hefei, China.
You HM; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.; The key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.; Institute for Liver Diseases of Anhui Medical University, Hefei, China.
Cheng M; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.; The key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.; Institute for Liver Diseases of Anhui Medical University, Hefei, China.
Yang Y; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.; The key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.; Institute for Liver Diseases of Anhui Medical University, Hefei, China.
Huang C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.; The key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.; Institute for Liver Diseases of Anhui Medical University, Hefei, China.
Li J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China. .; The key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China. .; Institute for Liver Diseases of Anhui Medical University, Hefei, China. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2021 Sep; Vol. 101 (9), pp. 1210-1224. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 Enzyme System*/genetics
Cytochrome P-450 Enzyme System*/metabolism
Cytochrome P-450 Enzyme System*/pharmacology
Intramolecular Oxidoreductases*/genetics
Intramolecular Oxidoreductases*/metabolism
Intramolecular Oxidoreductases*/pharmacology
Macrophage Activation*/drug effects
Macrophage Activation*/genetics
Macrophages*/drug effects
Macrophages*/metabolism
Chemical and Drug Induced Liver Injury/*metabolism
Animals ; Cells, Cultured ; Ethanol/adverse effects ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; RAW 264.7 Cells ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis.
Autorzy :
Nie L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhao P; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yue Z; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhang P; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Ji N; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Chen Q; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Chengdu, China.
Wang Q; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Chengdu, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Sep; Vol. 110 (3), pp. 497-510. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pyroptosis*/drug effects
Cytoplasm/*metabolism
DNA/*metabolism
DNA-Binding Proteins/*metabolism
Diabetes Mellitus, Experimental/*pathology
Macrophages/*pathology
Aging/pathology ; Animals ; Antigen Presentation/drug effects ; Chemotaxis/drug effects ; Cytokines/metabolism ; Glucose/toxicity ; Hyperglycemia/complications ; Inflammation Mediators/metabolism ; Macrophages/drug effects ; Metformin/pharmacology ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Periodontium/pathology ; Phagocytosis/drug effects ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Eupomatenes A - E: Neolignans isolated from the leaves of Australian rainforest plant Eupomatia laurina.
Autorzy :
Raju R; Department of Pharmacology, Western Sydney University, Campbelltown Campus, Sydney, Australia. Electronic address: .
Cullen JK; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Bruce ZC; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Reddell P; QBiotics Ltd, PO Box 1, Yungaburra, Queensland, Australia.
Münch G; Department of Pharmacology, Western Sydney University, Campbelltown Campus, Sydney, Australia.
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Źródło :
Fitoterapia [Fitoterapia] 2021 Sep; Vol. 153, pp. 104972. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Lignans/*pharmacology
Magnoliopsida/*chemistry
Animals ; Anti-Inflammatory Agents/isolation & purification ; Lignans/isolation & purification ; Macrophages/drug effects ; Mice ; Molecular Structure ; Nitric Oxide ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Leaves/chemistry ; Queensland ; RAW 264.7 Cells ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation.
Autorzy :
Liang B; Department of Implantology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, P. R. China.
Wang H; Department of Pathology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, P. R. China.
Wu D; Department of Implantology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, P. R. China.
Wang Z; Department of Implantology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, P. R. China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Sep; Vol. 110 (3), pp. 433-447. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Remodeling*
Cell Polarity*
Cellular Microenvironment*
Dental Implantation*
Alveolar Process/*pathology
Macrophages/*pathology
Animals ; Bone Regeneration ; Cell Differentiation ; Cell Proliferation ; Male ; Mesenchymal Stem Cells/metabolism ; Mice ; Models, Animal ; Osteoclasts/metabolism ; Osteogenesis ; Phenotype ; RAW 264.7 Cells ; Rats, Sprague-Dawley ; Titanium ; Tooth Extraction
Czasopismo naukowe
Tytuł :
Analysis of the microRNA and mRNA expression profile of ricin toxin-treated RAW264.7 cells reveals that miR-155-3p suppresses cell inflammation by targeting GAB2.
Autorzy :
Liu Z; College of Life Science, Jilin Agricultural University, Changchun, 130118, PR China.
Zhang X; Department of Cardiology, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Dong M; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, PR China.
Liu Z; Department of Cardiology, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Wang Y; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, PR China.
Yu H; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, PR China.
Yu K; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, PR China.
Xu N; Jilin Medical University, Jilin, 132013, PR China. Electronic address: .
Liu W; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, PR China. Electronic address: .
Song H; College of Life Science, Jilin Agricultural University, Changchun, 130118, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Sep 01; Vol. 347, pp. 67-77. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptome*
Adaptor Proteins, Signal Transducing/*metabolism
Inflammation/*chemically induced
Inflammation Mediators/*metabolism
Macrophages/*drug effects
MicroRNAs/*metabolism
RNA, Messenger/*metabolism
Ricin/*toxicity
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Inflammation/genetics ; Inflammation/metabolism ; Macrophages/metabolism ; Mice ; MicroRNAs/genetics ; RAW 264.7 Cells ; RNA, Messenger/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Neutrophil elastase-regulated macrophage sheddome/secretome and phagocytic failure.
Autorzy :
Ma J; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
Kummarapurugu AB; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
Hawkridge A; Department of Pharmaceutics/Department of Pharmacotherapy & Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia.
Ghosh S; Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Zheng S; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
Voynow JA; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Sep 01; Vol. 321 (3), pp. L555-L565. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phagocytosis*
Leukocyte Elastase/*metabolism
Lysosomes/*metabolism
Macrophages/*metabolism
Phagosomes/*metabolism
Adolescent ; Adult ; Animals ; Child ; Child, Preschool ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Female ; Humans ; Leukocyte Elastase/genetics ; Lysosomes/genetics ; Lysosomes/pathology ; Macrophages/physiology ; Male ; Mice ; Mice, Mutant Strains ; Phagosomes/genetics ; Phagosomes/pathology ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Machine learning identifies molecular regulators and therapeutics for targeting SARS-CoV2-induced cytokine release.
Autorzy :
Chan M; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Vijay S; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
McNevin J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Holland EC; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gujral TS; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA.
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Źródło :
Molecular systems biology [Mol Syst Biol] 2021 Sep; Vol. 17 (9), pp. e10426.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Cytokines/*metabolism
Host-Pathogen Interactions/*physiology
Animals ; Azetidines/pharmacology ; Host-Pathogen Interactions/drug effects ; Humans ; Imidazoles/pharmacology ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Janus Kinase 1/metabolism ; Lipopolysaccharides/toxicity ; Machine Learning ; Male ; Mice ; Mice, Inbred C57BL ; Neutrophils/virology ; Protein Kinase Inhibitors/pharmacology ; Purines/pharmacology ; Pyrazoles/pharmacology ; Pyridazines/pharmacology ; RAW 264.7 Cells ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi.
Autorzy :
Li LC; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China. Electronic address: .
Ning DS; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China. Electronic address: .
Fu YX; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China.
Pan ZH; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China. Electronic address: .
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Źródło :
Fitoterapia [Fitoterapia] 2021 Sep; Vol. 153, pp. 104949. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Illicium/*chemistry
Lignans/*pharmacology
Animals ; Anti-Inflammatory Agents/isolation & purification ; China ; Interleukin-6 ; Lignans/isolation & purification ; Mice ; Molecular Structure ; NF-kappa B ; Nitric Oxide ; Nitric Oxide Synthase Type II ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Leaves/chemistry ; Plants, Medicinal/chemistry ; RAW 264.7 Cells ; Signal Transduction ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
CITED2 inhibits STAT1-IRF1 signaling and atherogenesis.
Autorzy :
Zafar A; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Pong Ng H; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Diamond-Zaluski R; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Kim GD; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Ricky Chan E; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Dunwoodie SL; Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Faculties of Medicine and Science, UNSW Sydney, Sydney, NSW, Australia.
Smith JD; Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA.
Mahabeleshwar GH; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21833.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*genetics
Interferon Regulatory Factor-1/*genetics
Repressor Proteins/*genetics
STAT1 Transcription Factor/*genetics
Signal Transduction/*genetics
Trans-Activators/*genetics
Animals ; Female ; Inflammation/genetics ; Macrophages/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Promoter Regions, Genetic/genetics ; RAW 264.7 Cells ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Nicotinamide riboside, an NAD precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages.
Autorzy :
Kang H; Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
Park YK; Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
Lee JY; Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2021 Sep; Vol. 101 (9), pp. 1225-1237. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Macrophages*/drug effects
Macrophages*/metabolism
Inflammation/*metabolism
Niacinamide/*analogs & derivatives
Oxidative Stress/*drug effects
Pyridinium Compounds/*pharmacology
Sirtuin 1/*metabolism
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Ethanol/adverse effects ; Mice ; Niacinamide/pharmacology ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Chlorinated disinfection byproducts of diazepam perturb cell metabolism and induce behavioral toxicity in zebrafish larvae.
Autorzy :
Huang X; Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China; College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China; College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Zhao X; College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Zhang X; Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China.
Wang P; College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Zhu K; College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Shao B; Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Sep 01; Vol. 220, pp. 112416. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Behavior, Animal/*drug effects
Diazepam/*toxicity
Disinfectants/*toxicity
Water Pollutants, Chemical/*toxicity
Zebrafish/*physiology
Animals ; Diazepam/chemistry ; Disinfectants/chemistry ; Halogenation ; Hippocampus/drug effects ; Hippocampus/pathology ; Metabolome/drug effects ; Mice ; Neurons/drug effects ; RAW 264.7 Cells ; Rats ; Swimming/physiology ; Water Pollutants, Chemical/chemistry ; Zebrafish/growth & development ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA-146a inhibits autophagy to maintain the intracellular survival of Burkholderia pseudomallei by targeting LIPA.
Autorzy :
Hu ZQ; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China; Shigatse Branch, Xinqiao Hospital, Army 953 Hospital, Army Medical University, Shigatse, 857000, PR China.
Li Q; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China.
Hu ZH; Department of Respiratory, General Hospital of Center Theater of PLA, PLA's Health Service Scientific Research Plan, Wuhan, PR China.
Liu HC; Department of Respiratory, General Hospital of Center Theater of PLA, PLA's Health Service Scientific Research Plan, Wuhan, PR China.
Rao CL; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China.
Zhang MJ; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China.
Xia YP; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China.
Deng L; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China.
Mao XH; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China. Electronic address: .
Fang Y; Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Third Military Medical University (Army Medical University), Chongqing, PR China; Department of Respiratory, General Hospital of Center Theater of PLA, PLA's Health Service Scientific Research Plan, Wuhan, PR China. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2021 Sep; Vol. 158, pp. 104969. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Burkholderia pseudomallei*/genetics
Melioidosis*
MicroRNAs*/genetics
Sterol Esterase*
Macrophages/*microbiology
Animals ; Autophagy ; HEK293 Cells ; Humans ; Mice ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction.
Autorzy :
Zhang J; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Wu Q; Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yin C; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Jia X; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Zhao Z; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Zhang X; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.; Department of Dental Implantology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Yuan G; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Hu H; Department of Oral Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
Zhao Q; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Sep; Vol. 110 (3), pp. 485-496. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Polarity*/drug effects
Osseointegration*/drug effects
Calcium/*metabolism
Ceramics/*pharmacology
Macrophages/*cytology
Macrophages/*metabolism
Receptors, Calcium-Sensing/*metabolism
Animals ; Female ; Hydroxyapatites/pharmacology ; Ions ; Macrophages/drug effects ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Osteogenesis/drug effects ; RAW 264.7 Cells
Czasopismo naukowe

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