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Tytuł:
EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma.
Autorzy:
Li CF; Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.; National Cancer Research Institute, National Health Research Institutes, Tainan, Taiwan.; Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.
Chan TC; Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.; National Cancer Research Institute, National Health Research Institutes, Tainan, Taiwan.
Pan CT; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan.
Vejvisithsakul PP; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.; Section for Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Lai JC; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.
Chen SY; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.
Hsu YW; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.
Shiao MS; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Shiue YL; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan. .; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Oct; Vol. 44 (5), pp. 1133-1150. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*genetics
Carcinoma, Transitional Cell/*genetics
Cell Proliferation/*genetics
Membrane Glycoproteins/*genetics
Proteins/*genetics
Receptors, Purinergic P2X7/*genetics
Urinary Bladder Neoplasms/*genetics
Animals ; Carcinoma, Transitional Cell/metabolism ; Carcinoma, Transitional Cell/pathology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Immunoblotting ; Membrane Glycoproteins/metabolism ; Mice, Inbred NOD ; Mice, SCID ; Proteins/metabolism ; Receptors, Purinergic P2X7/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Smad Proteins/genetics ; Smad Proteins/metabolism ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Transplantation, Heterologous ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology ; Mice
Czasopismo naukowe
Tytuł:
Circular RNA hsa_circ_0081343 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-210-5p/DLX3 axis.
Autorzy:
Wang H; Department of Obstetrics and Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.
Luo C; Department of Obstetrics and Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.
Wu X; Department of Obstetrics and Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.
Zhang J; Institute of Maternal and Child Medicine, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.
Xu Z; Medical genetic center, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.
Liu Y; Medical genetic center, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.
Li B; Medical genetic center, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.
Li J; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. .
Xie J; Department of Obstetrics and Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China. .; Medical genetic center, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China. .
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Źródło:
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2021 Aug 09; Vol. 19 (1), pp. 123. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*genetics
Cell Movement/*genetics
Fetal Growth Retardation/*genetics
MicroRNAs/*genetics
Placenta/*metabolism
RNA, Circular/*genetics
Trophoblasts/*metabolism
Adult ; Case-Control Studies ; Cell Line ; Female ; Fetal Growth Retardation/metabolism ; Humans ; MicroRNAs/metabolism ; Pregnancy ; RNA, Circular/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Trophoblasts/physiology ; Young Adult
Czasopismo naukowe
Tytuł:
MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy.
Autorzy:
Li L; Department of Endocrinology and Metabolism, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
Chen X; Department of Endocrinology and Metabolism, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
Zhang H; Department of Endocrinology and Metabolism, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
Wang M; Department of Endocrinology and Metabolism, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
Lu W; Department of Endocrinology and Metabolism, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
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Źródło:
Analytical cellular pathology (Amsterdam) [Anal Cell Pathol (Amst)] 2021 Apr 28; Vol. 2021, pp. 6619870. Date of Electronic Publication: 2021 Apr 28 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Disease Models, Animal*
Gene Expression Regulation*
Apoptosis/*genetics
Cell Proliferation/*genetics
Diabetic Nephropathies/*genetics
Mannose-Binding Lectins/*genetics
Membrane Glycoproteins/*genetics
Receptors, Cell Surface/*genetics
Animals ; Blotting, Western ; Cell Cycle/genetics ; Cells, Cultured ; Diabetic Nephropathies/metabolism ; Female ; Humans ; Male ; Mannose-Binding Lectins/metabolism ; Membrane Glycoproteins/metabolism ; Mesangial Cells/cytology ; Mesangial Cells/metabolism ; Mice ; Middle Aged ; Receptors, Cell Surface/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Delivery of miR-424-5p via Extracellular Vesicles Promotes the Apoptosis of MDA-MB-231 TNBC Cells in the Tumor Microenvironment.
Autorzy:
Zhou Y; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Yamamoto Y; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Takeshita F; Department of Functional Analysis, FIOC, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Yamamoto T; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Xiao Z; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Ochiya T; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 15; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Tumor Microenvironment*
Extracellular Vesicles/*metabolism
Mesenchymal Stem Cells/*metabolism
MicroRNAs/*genetics
Triple Negative Breast Neoplasms/*genetics
Animals ; B7-H1 Antigen/genetics ; Base Sequence ; Cell Line, Tumor ; Cytokines/metabolism ; Exosomes/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Leukocytes, Mononuclear/cytology ; Mice ; Mice, Inbred BALB C ; Neoplasm Recurrence, Local ; Particle Size ; Reverse Transcriptase Polymerase Chain Reaction ; Triple Negative Breast Neoplasms/metabolism
Czasopismo naukowe
Tytuł:
Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE Mice by Activating Autophagy and Reducing ER Stress and Apoptosis.
Autorzy:
Nasiri-Ansari N; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Nikolopoulou C; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Papoutsi K; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kyrou I; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.; Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK.; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Mantzoros CS; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA 02215, USA.
Kyriakopoulos G; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Department of Pathology, Evangelismos Hospital, 10676 Athens, Greece.
Chatzigeorgiou A; Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kalotychou V; 1st Department of Internal Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Randeva MS; Human Metabolism Research Unit, WISDEM Centre, NHS Trust, Coventry CV2 2DX, UK.
Chatha K; Department of Biochemistry & Immunology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.
Kontzoglou K; Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, Athens University Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kaltsas G; Endocrine Oncology Unit, 1st Department of Propaupedic Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Papavassiliou AG; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Randeva HS; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.; Human Metabolism Research Unit, WISDEM Centre, NHS Trust, Coventry CV2 2DX, UK.; Division of Translational and Experimental Medicine-Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Kassi E; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Endocrine Oncology Unit, 1st Department of Propaupedic Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 15; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E/*deficiency
Apoptosis/*drug effects
Autophagy/*drug effects
Benzhydryl Compounds/*pharmacology
Endoplasmic Reticulum Stress/*drug effects
Glucosides/*pharmacology
Non-alcoholic Fatty Liver Disease/*prevention & control
Animals ; Apolipoproteins E/genetics ; Apoptosis/genetics ; Autophagy/genetics ; Benzhydryl Compounds/administration & dosage ; Diet, High-Fat/adverse effects ; Endoplasmic Reticulum Chaperone BiP ; Endoplasmic Reticulum Stress/genetics ; Gene Expression Regulation/drug effects ; Glucosides/administration & dosage ; Immunoblotting ; Lipogenesis/drug effects ; Lipogenesis/genetics ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sodium-Glucose Transporter 2 Inhibitors/administration & dosage ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Mice
Czasopismo naukowe
Tytuł:
Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome.
Autorzy:
Gong Y; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, People's Republic of China.; Reproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and children's Hospital of Chengdu Medical College, Chengdu, Sichuan, People's Republic of China.
Luo S; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, People's Republic of China.
Fan P; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.; Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, People's Republic of China.
Zhu H; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, People's Republic of China.
Li Y; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, People's Republic of China.
Huang W; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China. .; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, People's Republic of China. .; Department of Reproductive Medicine, West China Second University Hospital of Sichuan University, #1416 Chenglong Road, JinJiang District, Chengdu, Sichuan, 610041, People's Republic of China. .
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Źródło:
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2020 Dec 07; Vol. 18 (1), pp. 121. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Apoptosis/*drug effects
Granulosa Cells/*drug effects
Growth Hormone/*administration & dosage
Phosphatidylinositol 3-Kinases/*metabolism
Polycystic Ovary Syndrome/*drug therapy
Proto-Oncogene Proteins c-akt/*metabolism
Reactive Oxygen Species/*antagonists & inhibitors
Apoptosis/genetics ; Blotting, Western ; Caspase 3/metabolism ; Cells, Cultured ; Female ; Gene Expression Regulation/drug effects ; Granulosa Cells/cytology ; Granulosa Cells/metabolism ; Humans ; Oocyte Retrieval ; Phosphatidylinositol 3-Kinases/genetics ; Polycystic Ovary Syndrome/metabolism ; Polycystic Ovary Syndrome/pathology ; Prospective Studies ; Proto-Oncogene Proteins c-akt/genetics ; Reactive Oxygen Species/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł:
Cannabinoid-Induced Autophagy and Heme Oxygenase-1 Determine the Fate of Adipose Tissue-Derived Mesenchymal Stem Cells under Stressful Conditions.
Autorzy:
Bublitz K; Institute of Pharmacology and Toxicology, Rostock University Medical Center, Schillingallee 70, D-18057 Rostock, Germany.
Böckmann S; Institute of Pharmacology and Toxicology, Rostock University Medical Center, Schillingallee 70, D-18057 Rostock, Germany.
Peters K; Department of Cell Biology, Rostock University Medical Center, Schillingallee 69, D-18057 Rostock, Germany.
Hinz B; Institute of Pharmacology and Toxicology, Rostock University Medical Center, Schillingallee 70, D-18057 Rostock, Germany.
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Źródło:
Cells [Cells] 2020 Oct 15; Vol. 9 (10). Date of Electronic Publication: 2020 Oct 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Autophagy/*drug effects
Cannabinoids/*pharmacology
Heme Oxygenase-1/*physiology
Mesenchymal Stem Cells/*cytology
Mesenchymal Stem Cells/*drug effects
Arachidonic Acids/pharmacology ; Cannabidiol/pharmacology ; Caspase 3/physiology ; Cells, Cultured ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation ; Gene Knockdown Techniques ; Humans ; Macrolides/pharmacology ; Metalloporphyrins/pharmacology ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Oxidative Stress ; Protoporphyrins/pharmacology ; RNA, Small Interfering/genetics ; Receptors, Cannabinoid/physiology ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Action of Akt Pathway on La-Induced Hippocampal Neuron Apoptosis of Rats in the Growth Stage.
Autorzy:
Wang J; Institute of Molecular Medicine, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.; Department of Nursing, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.
Wu T; Institute of Molecular Medicine, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.; Department of Nursing, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.
Ma L; Institute of Molecular Medicine, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.; Department of Nursing, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.
Guo Y; Institute of Molecular Medicine, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.; Department of Nursing, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.
Huang Y; Institute of Molecular Medicine, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.; Department of Nursing, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China.
Zheng L; Institute of Molecular Medicine, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China. .; Department of Nursing, School of medicine, Eastern Liaoning University, Dandong, 118003, Liaoning, People's Republic of China. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2020 Aug; Vol. 38 (2), pp. 434-446. Date of Electronic Publication: 2020 May 08.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Lanthanum/*toxicity
Memory/*drug effects
Neurons/*drug effects
Proto-Oncogene Proteins c-akt/*drug effects
Animals ; Caspase 3/drug effects ; Caspase 3/metabolism ; Caspase 9/drug effects ; Caspase 9/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Learning/drug effects ; Neurons/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/drug effects ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Wistar ; Reverse Transcriptase Polymerase Chain Reaction ; bcl-2-Associated X Protein/drug effects ; bcl-2-Associated X Protein/metabolism ; bcl-Associated Death Protein/drug effects ; bcl-Associated Death Protein/metabolism ; bcl-X Protein/drug effects ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł:
Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner.
Autorzy:
Urata Y; Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine, Interdisciplinary School of Health Sciences, University of Ottawa; Chronic Disease Program, Ottawa Hospital Research Institute, Critical Care Wing, 3rd floor, Room W3107, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada. .; Department of Obstetrics and Gynecology, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. .
Salehi R; Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine, Interdisciplinary School of Health Sciences, University of Ottawa; Chronic Disease Program, Ottawa Hospital Research Institute, Critical Care Wing, 3rd floor, Room W3107, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
Lima PDA; Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine, Interdisciplinary School of Health Sciences, University of Ottawa; Chronic Disease Program, Ottawa Hospital Research Institute, Critical Care Wing, 3rd floor, Room W3107, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Queen's Cardiopulmonary Unit, Queen's University, BioSciences Complex, Room 1605, 116 Barrie Street, Kingston, ON, K7L 3N6, Canada.
Osuga Y; Department of Obstetrics and Gynecology, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Tsang BK; Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine, Interdisciplinary School of Health Sciences, University of Ottawa; Chronic Disease Program, Ottawa Hospital Research Institute, Critical Care Wing, 3rd floor, Room W3107, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
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Źródło:
Journal of ovarian research [J Ovarian Res] 2020 Jan 08; Vol. 13 (1), pp. 5. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation*
Apoptosis/*genetics
Cell Proliferation/*genetics
Granulosa Cells/*metabolism
Neuropeptide Y/*genetics
Ovarian Follicle/*metabolism
Animals ; Blotting, Western ; Cells, Cultured ; Female ; Granulosa Cells/cytology ; MAP Kinase Signaling System ; Neuropeptide Y/metabolism ; Ovarian Follicle/cytology ; Ovary/cytology ; Ovary/metabolism ; Rats, Sprague-Dawley ; Receptors, Neuropeptide Y/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Stability of selected reference genes in Sf9 cells treated with extrinsic apoptotic agents.
Autorzy:
Shu B; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Zhongkai University of Agriculture and Engineering, Guangzhou, China.; Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, China.; Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, China.
Zhang J; Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, China.; Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, China.
Zeng J; Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, China.; Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, China.
Cui G; Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, China.; Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, China.
Zhong G; Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, China. .; Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, China. .
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14147. Date of Electronic Publication: 2019 Oct 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Insect*
Apoptosis/*genetics
Real-Time Polymerase Chain Reaction/*standards
Reverse Transcriptase Polymerase Chain Reaction/*standards
Animals ; Apoptosis/drug effects ; Apoptosis/radiation effects ; Camptothecin/toxicity ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/genetics ; Insect Proteins/genetics ; Limonins/toxicity ; Peptide Elongation Factors/genetics ; Reference Standards ; Ribosomal Proteins/genetics ; Sf9 Cells ; Spodoptera ; Tubulin/genetics ; Ultraviolet Rays
Czasopismo naukowe
Tytuł:
[PDCD4 enhances the inhibitory effect of As(2)O(3) on the growth and NF-κB signaling pathway in neuroblastoma cells].
Autorzy:
Liu HJ; Department of Pediatrics, Henan Provincial People's Hospital, Zhengzhou 450000, China.
Li GL; Department of Pediatrics, Henan Provincial People's Hospital, Zhengzhou 450000, China.
Lei PC; Department of Hematology, Henan Provincial People's Hospital, Zhengzhou 450000, China.
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Źródło:
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2019 Sep 23; Vol. 41 (9), pp. 675-680.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Apoptosis Regulatory Proteins/*genetics
Arsenic Trioxide/*pharmacology
NF-kappa B/*physiology
Neuroblastoma/*drug therapy
RNA-Binding Proteins/*genetics
Signal Transduction/*drug effects
Antineoplastic Agents ; Apoptosis Regulatory Proteins/metabolism ; Cell Differentiation/drug effects ; Cell Survival/drug effects ; Humans ; RNA-Binding Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
[Effects of miR-144 on proliferation, apoptosis and cisplatin resistance by targeting MYCN in pediatric neuroblastoma].
Autorzy:
Liu HJ; Department of Pediatrics, Henan People's Hospital, Zhengzhou 450000, China.
Li GL; Department of Pediatrics, Henan People's Hospital, Zhengzhou 450000, China.
Lei PC; Department of Hematology, Henan People's Hospital, Zhengzhou 450000, China.
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Źródło:
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2019 Jul 23; Vol. 41 (7), pp. 516-521.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*genetics
Cell Proliferation/*genetics
Cisplatin/*pharmacology
Drug Resistance, Neoplasm/*genetics
MicroRNAs/*genetics
N-Myc Proto-Oncogene Protein/*therapeutic use
Neuroblastoma/*drug therapy
Neuroblastoma/*genetics
Antineoplastic Agents/pharmacology ; Apoptosis/physiology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Child ; Gene Expression Regulation, Neoplastic ; Humans ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/pathology ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Knockdown expression of MECR, a novel gene of mitochondrial FAS II inhibits growth and colony-formation, promotes apoptosis of hepatocelluar carcinoma cells.
Autorzy:
Cai Y; Department of Biliary Surgery, West China Hospital, Sichuan University.
Lin Y; Department of Biliary Surgery, West China Hospital, Sichuan University.
Xiong X; Department of Biliary Surgery, West China Hospital, Sichuan University.
Lu J; Department of Biliary Surgery, West China Hospital, Sichuan University.
Zhou R; Department of Biliary Surgery, West China Hospital, Sichuan University.
Jin Y; Department of Biliary Surgery, West China Hospital, Sichuan University.
You Z; Department of Biliary Surgery, West China Hospital, Sichuan University.
Ye H; Department of Biliary Surgery, West China Hospital, Sichuan University.
Li F; Department of Biliary Surgery, West China Hospital, Sichuan University.
Cheng N; Department of Biliary Surgery, West China Hospital, Sichuan University.
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Źródło:
Bioscience trends [Biosci Trends] 2019 Jul 22; Vol. 13 (3), pp. 234-244. Date of Electronic Publication: 2019 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*physiology
Carcinoma, Hepatocellular/*metabolism
Cell Cycle/*physiology
Liver Neoplasms/*metabolism
Oxidoreductases Acting on CH-CH Group Donors/*metabolism
Apoptosis/genetics ; Blotting, Western ; Carcinoma, Hepatocellular/genetics ; Cell Cycle/genetics ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/physiology ; Humans ; Liver Neoplasms/genetics ; Mitochondria/genetics ; Mitochondria/metabolism ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł:
Transplantation of neural stem cells in the mouse model of ischemic brain stroke and expression of genes involved in programmed cell death.
Autorzy:
Hribljan V
Salamon I
Đemaili A
Alić I
Mitrečić D; Dinko Mitrečić, Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 12, Zagreb, Croatia, .
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Źródło:
Croatian medical journal [Croat Med J] 2018 Oct 31; Vol. 59 (5), pp. 203-212.
Typ publikacji:
Journal Article
MeSH Terms:
Disease Models, Animal*
Stem Cell Transplantation*
Apoptosis/*genetics
Brain Ischemia/*therapy
Gene Expression Regulation/*physiology
Neural Stem Cells/*transplantation
Stroke/*therapy
Animals ; Apoptosis Inducing Factor/genetics ; Brain Ischemia/genetics ; Caspases/genetics ; Cell Differentiation ; Cyclophilin A/genetics ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Protein Kinases/genetics ; RNA, Messenger/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Stroke/genetics ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł:
Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17.
Autorzy:
Urriola-Muñoz P; Instituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile. .; Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago 7820436, Chile. .
Lagos-Cabré R; Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago 7820436, Chile. .
Patiño-García D; Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago 7820436, Chile. .
Reyes JG; Instituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile. .
Moreno RD; Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago 7820436, Chile. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Jul 31; Vol. 19 (8). Date of Electronic Publication: 2018 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
ADAM17 Protein/*metabolism
Apoptosis/*drug effects
Benzhydryl Compounds/*toxicity
Endocrine Disruptors/*toxicity
Phenols/*toxicity
Alkaline Phosphatase/metabolism ; Blotting, Western ; Cell Line, Tumor ; Flow Cytometry ; Humans ; Immunohistochemistry ; Male ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Porphyromonas gingivalis Induces Apoptosis and Autophagy via ER Stress in Human Umbilical Vein Endothelial Cells.
Autorzy:
Hirasawa M; Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Matsudo-shi, Chiba-ken, Japan.
Kurita-Ochiai T; Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Matsudo-shi, Chiba-ken, Japan.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2018 Jul 29; Vol. 2018, pp. 1967506. Date of Electronic Publication: 2018 Jul 29 (Print Publication: 2018).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*physiology
Autophagy/*physiology
Cell Survival/*physiology
Human Umbilical Vein Endothelial Cells/*cytology
Human Umbilical Vein Endothelial Cells/*microbiology
Porphyromonas gingivalis/*pathogenicity
Caspase 12/genetics ; Caspase 12/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 8/genetics ; Caspase 8/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cell Death/physiology ; Cell Proliferation/physiology ; DNA Fragmentation ; Endoplasmic Reticulum Chaperone BiP ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factor CHOP/genetics ; Transcription Factor CHOP/metabolism
Czasopismo naukowe
Tytuł:
Involvement of oncogenic tyrosine kinase NPM-ALK in trifluoperazine-induced cell cycle arrest and apoptosis in ALK anaplastic large cell lymphoma.
Autorzy:
Hu L; a State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai , People's Republic of China.; b Key Laboratory of Organofluorine Chemistry, Chinese Academy of Sciences , Shanghai Institute of Organic Chemistry , Shanghai , People's Republic of China.
Zhang X; a State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai , People's Republic of China.
Wang J; a State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai , People's Republic of China.
Wang S; a State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai , People's Republic of China.
Amin HM; c Department of Hematopathology , The University of Texas M. D. Anderson Cancer Center , Houston , TX , USA.
Shi P; a State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai , People's Republic of China.; b Key Laboratory of Organofluorine Chemistry, Chinese Academy of Sciences , Shanghai Institute of Organic Chemistry , Shanghai , People's Republic of China.
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Źródło:
Hematology (Amsterdam, Netherlands) [Hematology] 2018 Jun; Vol. 23 (5), pp. 284-290. Date of Electronic Publication: 2017 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Cell Cycle Checkpoints/*drug effects
Protein-Tyrosine Kinases/*metabolism
Trifluoperazine/*pharmacology
Anaplastic Lymphoma Kinase ; Antipsychotic Agents/pharmacology ; Apoptosis/genetics ; Blotting, Western ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Humans ; Lymphoma, Large-Cell, Anaplastic/genetics ; Lymphoma, Large-Cell, Anaplastic/metabolism ; Lymphoma, Large-Cell, Anaplastic/pathology ; Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts.
Autorzy:
Teoh PL; a Biotechnology Research Institute, Universiti Malaysia Sabah , Jalan UMS , Kota Kinabalu , Sabah , Malaysia.
Cheng AY; a Biotechnology Research Institute, Universiti Malaysia Sabah , Jalan UMS , Kota Kinabalu , Sabah , Malaysia.
Liau M
Lem FF; a Biotechnology Research Institute, Universiti Malaysia Sabah , Jalan UMS , Kota Kinabalu , Sabah , Malaysia.
Kaling GP; a Biotechnology Research Institute, Universiti Malaysia Sabah , Jalan UMS , Kota Kinabalu , Sabah , Malaysia.
Chua FN; b Faculty of Science & Natural Resources, Universiti Malaysia Sabah , Jalan UMS, Kota Kinabalu , Sabah , Malaysia.
Cheong BE; a Biotechnology Research Institute, Universiti Malaysia Sabah , Jalan UMS , Kota Kinabalu , Sabah , Malaysia.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2017 Dec; Vol. 55 (1), pp. 394-401.
Typ publikacji:
Journal Article
MeSH Terms:
Acanthaceae/*chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Breast Neoplasms/*drug therapy
Cell Proliferation/*drug effects
Plant Extracts/*pharmacology
Plant Roots/*chemistry
Uterine Cervical Neoplasms/*drug therapy
Animals ; Antineoplastic Agents, Phytogenic/isolation & purification ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Nucleus Shape/drug effects ; Chromatin Assembly and Disassembly/drug effects ; Dose-Response Relationship, Drug ; Female ; Flow Cytometry ; Gas Chromatography-Mass Spectrometry ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Membrane Potential, Mitochondrial/drug effects ; Mice ; NIH 3T3 Cells ; Phytotherapy ; Plant Extracts/isolation & purification ; Plants, Medicinal ; Reverse Transcriptase Polymerase Chain Reaction ; Solvents/chemistry ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
Czasopismo naukowe

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