Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""RNA"" wg kryterium: Temat


Tytuł :
tRNA-like leader-trailer interaction promotes 3'-end maturation of MALAT1.
Autorzy :
Torabi SF; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06536, USA.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
DeGregorio SJ; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06536, USA.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Steitz JA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06536, USA.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Pokaż więcej
Źródło :
RNA (New York, N.Y.) [RNA] 2021 Oct; Vol. 27 (10), pp. 1140-1147. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA 3' End Processing*
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
RNA, Long Noncoding/*genetics
RNA, Messenger/*genetics
RNA, Transfer/*genetics
Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/pathology ; Base Pairing ; Base Sequence ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Nucleic Acid Conformation ; RNA Stability ; RNA, Long Noncoding/metabolism ; RNA, Messenger/metabolism ; RNA, Transfer/metabolism ; Ribonuclease P/genetics ; Ribonuclease P/metabolism
Czasopismo naukowe
Tytuł :
FLAME: long-read bioinformatics tool for comprehensive spliceome characterization.
Autorzy :
Holmqvist I; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden.
Bäckerholm A; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden.
Tian Y; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden.
Xie G; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden.
Thorell K; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden.
Tang KW; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 46 Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, Sahlgrenska Center for Cancer Research, Västra Götaland Region, Department of Clinical Microbiology, Sahlgrenska University Hospital, 413 46 Gothenburg, Sweden.
Pokaż więcej
Źródło :
RNA (New York, N.Y.) [RNA] 2021 Oct; Vol. 27 (10), pp. 1127-1139. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
Software*
Epstein-Barr Virus Infections/*genetics
Herpesvirus 4, Human/*genetics
Nasopharyngeal Carcinoma/*genetics
Nasopharyngeal Neoplasms/*genetics
RNA, Long Noncoding/*genetics
RNA, Messenger/*genetics
Benchmarking ; Cell Line, Tumor ; Computational Biology/methods ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Infections/pathology ; Epstein-Barr Virus Infections/virology ; Exons ; Herpesvirus 4, Human/pathogenicity ; High-Throughput Nucleotide Sequencing ; Humans ; Introns ; Nanopore Sequencing ; Nasopharyngeal Carcinoma/metabolism ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Carcinoma/virology ; Nasopharyngeal Neoplasms/metabolism ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/virology ; RNA, Long Noncoding/metabolism ; RNA, Messenger/metabolism ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Nucleolar maturation of the human small subunit processome.
Autorzy :
Singh S; Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA.
Vanden Broeck A; Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA.
Miller L; Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA.; Tri-Institutional Training Program in Chemical Biology, The Rockefeller University, New York, NY 10065, USA.
Chaker-Margot M; Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA.; Tri-Institutional Training Program in Chemical Biology, The Rockefeller University, New York, NY 10065, USA.
Klinge S; Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA.
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 10; Vol. 373 (6560), pp. eabj5338. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Folding*
RNA Stability*
Cell Nucleolus/*ultrastructure
RNA, Small Nucleolar/*chemistry
Cell Nucleolus/metabolism ; Cryoelectron Microscopy ; DEAD-box RNA Helicases/chemistry ; Humans ; RNA Cleavage ; RNA Splicing Factors/chemistry
Czasopismo naukowe
Tytuł :
Regulation and functional consequences of mGlu 4 RNA editing.
Autorzy :
Hofmann CS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, USA.
Carrington S; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, USA.
Keller AN; Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Gregory KJ; Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Niswender CM; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
Pokaż więcej
Źródło :
RNA (New York, N.Y.) [RNA] 2021 Oct; Vol. 27 (10), pp. 1220-1240. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Editing*
RNA, Messenger/*genetics
Receptors, Metabotropic Glutamate/*genetics
Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Amino Acid Sequence ; Animals ; Base Pairing ; Base Sequence ; Birds ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Corpus Striatum/cytology ; Corpus Striatum/metabolism ; HEK293 Cells ; Hippocampus/cytology ; Hippocampus/metabolism ; Humans ; Models, Molecular ; Neurons/cytology ; Neurons/metabolism ; Nucleic Acid Conformation ; Point Mutation ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/chemistry ; Receptors, Metabotropic Glutamate/metabolism ; Reptiles ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia.
Autorzy :
Monaghan CE; Department of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093.; HHMI, University of California San Diego, La Jolla, CA 92093.
Adamson SI; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030.; Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT 06030.
Kapur M; Department of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093.; HHMI, University of California San Diego, La Jolla, CA 92093.
Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030.; Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT 06030.
Ackerman SL; Department of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093; .; HHMI, University of California San Diego, La Jolla, CA 92093.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 28; Vol. 118 (39).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polyadenylation*
RNA Processing, Post-Transcriptional*
Cerebellar Diseases/*pathology
Neurodegenerative Diseases/*pathology
RNA, Messenger/*metabolism
RNA, Transfer/*metabolism
RNA-Binding Proteins/*physiology
Transcription Factors/*physiology
Animals ; Cerebellar Diseases/genetics ; Cerebellar Diseases/metabolism ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA, Messenger/genetics ; RNA, Transfer/genetics
SCR Disease Name :
Pontocerebellar Hypoplasia
Czasopismo naukowe
Tytuł :
SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
Autorzy :
Kim JH; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Jeong K; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Li J; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Murphy JM; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Vukadin L; Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Stone JK; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Richard A; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Tran J; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Gillespie GY; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Flemington EK; Department of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.
Sobol RW; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA. .; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA. .
Lim SS; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, USA. .
Ahn EE; Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. .; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Sep 21; Vol. 12 (1), pp. 5551. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
RNA Splicing*
Brain Neoplasms/*genetics
DNA-Binding Proteins/*genetics
Glioblastoma/*genetics
Heterogeneous-Nuclear Ribonucleoproteins/*genetics
Minor Histocompatibility Antigens/*genetics
Nerve Tissue Proteins/*genetics
Polypyrimidine Tract-Binding Protein/*genetics
RNA Splicing Factors/*genetics
Repressor Proteins/*genetics
Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/metabolism ; Exons ; Gene Expression Regulation, Neoplastic ; Glioblastoma/metabolism ; Glioblastoma/mortality ; Glioblastoma/pathology ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/metabolism ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Heterografts ; Humans ; Introns ; Mice ; Minor Histocompatibility Antigens/metabolism ; Nerve Tissue Proteins/metabolism ; Neuroglia/metabolism ; Neuroglia/pathology ; Neurons/metabolism ; Neurons/pathology ; Polypyrimidine Tract-Binding Protein/metabolism ; RNA Splicing Factors/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Repressor Proteins/metabolism ; Signal Transduction ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology ; Survival Analysis
Czasopismo naukowe
Tytuł :
Efficient RNA Virus Targeting via CRISPR/CasRx in Fish.
Autorzy :
Wang Q; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Liu Y; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory for Aquatic Economic Animals and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Han C; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory for Aquatic Economic Animals and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Yang M; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Huang F; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.
Duan X; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.
Wang S; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Yu Y; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Liu J; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.
Yang H; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Lu D; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory for Aquatic Economic Animals and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Zhao H; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Zhang Y; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory for Aquatic Economic Animals and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Qin Q; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2021 Sep 09; Vol. 95 (19), pp. e0046121. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
RNA Interference*
CRISPR-Associated Proteins/*metabolism
Fish Diseases/*virology
Nodaviridae/*genetics
Perciformes/*virology
RNA Virus Infections/*veterinary
Animals ; Nodaviridae/physiology ; RNA Virus Infections/virology ; RNA, Viral/genetics
Czasopismo naukowe
Tytuł :
A call for direct sequencing of full-length RNAs to identify all modifications.
Autorzy :
Alfonzo JD; Department of Microbiology; Center for RNA Biology and Ohio State Biochemistry Program, Ohio State University, Columbus, OH, USA.
Brown JA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Byers PH; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.
Cheung VG; Department of Pediatrics, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. .
Maraia RJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Ross RL; Department of Cancer and Cell Biology, Metabolomics Mass Spectrometry Laboratory, University of Cincinnati, Cincinnati, OH, USA.
Pokaż więcej
Źródło :
Nature genetics [Nat Genet] 2021 Aug; Vol. 53 (8), pp. 1113-1116.
Typ publikacji :
Journal Article
MeSH Terms :
RNA*/chemistry
RNA*/genetics
RNA*/metabolism
High-Throughput Nucleotide Sequencing/*methods
Sequence Analysis, RNA/*methods
Drug Development ; Humans ; Mass Spectrometry ; RNA Viruses/genetics ; Sequence Analysis, RNA/standards
Czasopismo naukowe
Tytuł :
SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.
Autorzy :
Fukumura K; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan. .
Yoshimoto R; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan.; Department of Applied Biological Sciences, Faculty of Agriculture, Setsunan University, Hirakata, Osaka, Japan.
Sperotto L; Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.; Bavarian NMR Center (BNMRZ), Chemistry Department, Technical University of Munich, Garching, Germany.
Kang HS; Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.; Bavarian NMR Center (BNMRZ), Chemistry Department, Technical University of Munich, Garching, Germany.
Hirose T; Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Inoue K; Department of Biology, Graduate School of Science, Kobe University, Kobe, Hyogo, Japan.
Sattler M; Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.; Bavarian NMR Center (BNMRZ), Chemistry Department, Technical University of Munich, Garching, Germany.
Mayeda A; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Aug 13; Vol. 12 (1), pp. 4910. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
Introns/*genetics
RNA Splicing Factors/*metabolism
Splicing Factor U2AF/*metabolism
Base Sequence ; Binding Sites/genetics ; Humans ; Models, Genetic ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Binding ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA Splicing Factors/genetics ; Ribonucleoprotein, U2 Small Nuclear/genetics ; Ribonucleoprotein, U2 Small Nuclear/metabolism ; Spliceosomes/genetics ; Spliceosomes/metabolism ; Splicing Factor U2AF/genetics
Czasopismo naukowe
Tytuł :
POINT technology illuminates the processing of polymerase-associated intact nascent transcripts.
Autorzy :
Sousa-Luís R; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisbon, Portugal.
Dujardin G; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Zukher I; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Kimura H; Cell Biology Centre, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Weldon C; Wellcome Trust Center for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Carmo-Fonseca M; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisbon, Portugal. Electronic address: .
Proudfoot NJ; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Electronic address: .
Nojima T; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK; Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: .
Pokaż więcej
Źródło :
Molecular cell [Mol Cell] 2021 May 06; Vol. 81 (9), pp. 1935-1950.e6. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nanotechnology*
RNA Splicing*
RNA-Seq*
Transcription, Genetic*
RNA Polymerase II/*metabolism
RNA Precursors/*biosynthesis
RNA, Messenger/*biosynthesis
Exoribonucleases/genetics ; Exoribonucleases/metabolism ; HCT116 Cells ; HeLa Cells ; Humans ; Kinetics ; Polyadenylation ; RNA Caps ; RNA Polymerase II/genetics ; RNA Precursors/genetics ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
Autorzy :
Poirier EZ; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK. .
Buck MD; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK.
Chakravarty P; Bioinformatics and Biostatistics, Francis Crick Institute, London NW1 1AT, UK.
Carvalho J; Experimental Histopathology, Francis Crick Institute, London NW1 1AT, UK.
Frederico B; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK.
Cardoso A; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK.
Healy L; Human Embryo and Stem Cell Unit, Francis Crick Institute, London NW1 1AT, UK.
Ulferts R; Cell Biology of Infection Laboratory, Francis Crick Institute, London NW1 1AT, UK.
Beale R; Cell Biology of Infection Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Division of Medicine, University College London, London WC1E 6BT, UK.
Reis E Sousa C; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK. .
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2021 Jul 09; Vol. 373 (6551), pp. 231-236.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Interference*
DEAD-box RNA Helicases/*genetics
DEAD-box RNA Helicases/*metabolism
RNA Viruses/*physiology
RNA, Viral/*metabolism
Ribonuclease III/*genetics
Ribonuclease III/*metabolism
Stem Cells/*enzymology
Stem Cells/*virology
Alternative Splicing ; Animals ; Brain/enzymology ; Brain/virology ; Cell Line ; DEAD-box RNA Helicases/chemistry ; Humans ; Immunity, Innate ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mice ; Organoids/enzymology ; Organoids/virology ; RNA Virus Infections/enzymology ; RNA Virus Infections/immunology ; RNA Virus Infections/virology ; RNA Viruses/genetics ; RNA Viruses/immunology ; RNA, Double-Stranded/metabolism ; RNA, Small Interfering/metabolism ; Ribonuclease III/chemistry ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Virus Replication ; Zika Virus/genetics ; Zika Virus/immunology ; Zika Virus/physiology ; Zika Virus Infection/enzymology ; Zika Virus Infection/immunology ; Zika Virus Infection/virology
Czasopismo naukowe
Tytuł :
The Exon Junction Complex Core Represses Cancer-Specific Mature mRNA Re-splicing: A Potential Key Role in Terminating Splicing.
Autorzy :
Otani Y; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Aichi, Japan.; Laboratories of Discovery Research, Nippon Shinyaku Co., Ltd., Kyoto 601-8550, Kyoto, Japan.
Fujita KI; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Aichi, Japan.
Kameyama T; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Aichi, Japan.; Department of Physiology, School of Medicine, Fujita Health University, Toyoake 470-1192, Aichi, Japan.
Mayeda A; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Aichi, Japan.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 17; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Exons*
Gene Expression Regulation, Neoplastic*
RNA Splicing*
Neoplasms/*genetics
RNA Precursors/*genetics
RNA, Messenger/*genetics
Cell Line, Tumor ; Eukaryotic Initiation Factor-4A/genetics ; Eukaryotic Initiation Factor-4A/metabolism ; Humans ; Models, Biological ; Neoplasms/metabolism ; Protein Binding ; RNA Transport ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
A single m A modification in U6 snRNA diversifies exon sequence at the 5' splice site.
Autorzy :
Ishigami Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Ohira T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Isokawa Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa-shi, Chiba, Japan.
Suzuki T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 May 28; Vol. 12 (1), pp. 3244. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
RNA Splicing*
RNA, Fungal/*metabolism
RNA, Small Nuclear/*metabolism
Schizosaccharomyces/*genetics
3' Untranslated Regions/genetics ; 5' Untranslated Regions/genetics ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Exons/genetics ; Mass Spectrometry ; Methyltransferases/genetics ; Methyltransferases/isolation & purification ; Methyltransferases/metabolism ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA Splice Sites/genetics ; RNA, Fungal/genetics ; RNA, Small Nuclear/genetics ; RNA-Seq ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Ribonucleoprotein, U4-U6 Small Nuclear ; Ribonucleoprotein, U5 Small Nuclear ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/isolation & purification ; Schizosaccharomyces pombe Proteins/metabolism
Czasopismo naukowe
Tytuł :
Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.
Autorzy :
Yeh FL; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Chang SL; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Ahmed GR; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Liu HI; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Tung L; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Yeh CS; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Lanier LS; Department of Biology, Washington and Lee University, Lexington, VA, USA.
Maeder C; Department of Chemistry, Trinity University, San Antonio, TX, USA.
Lin CM; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Tsai SC; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Hsiao WY; Genomics Research Center, Academia Sinica, Taipei, Taiwan.; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chang WH; Institute of Chemistry, Academia Sinica, Taipei, Taiwan.
Chang TH; Genomics Research Center, Academia Sinica, Taipei, Taiwan. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 May 25; Vol. 12 (1), pp. 3082. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
DEAD-box RNA Helicases/*metabolism
Nuclear Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Spliceosomes/*metabolism
Adenosine Triphosphate/metabolism ; DEAD-box RNA Helicases/genetics ; Humans ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Mutation ; Nuclear Proteins/genetics ; Phosphorylation ; Protein Binding ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA-Binding Proteins/genetics ; Ribonuclease H/metabolism ; Ribonucleoproteins, Small Nuclear/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Spliceosomes/genetics
Czasopismo naukowe
Tytuł :
Rapidly Growing Protein-Centric Technologies to Extensively Identify Protein-RNA Interactions: Application to the Analysis of Co-Transcriptional RNA Processing.
Autorzy :
Masuda A; Center for Neurological Diseases and Cancer, Division of Neurogenetics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Kawachi T; Center for Neurological Diseases and Cancer, Division of Neurogenetics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Ohno K; Center for Neurological Diseases and Cancer, Division of Neurogenetics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 18; Vol. 22 (10). Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
RNA Processing, Post-Transcriptional*
Immunoprecipitation/*methods
RNA, Messenger/*genetics
RNA, Messenger/*metabolism
RNA-Binding Proteins/*metabolism
Binding Sites ; Gene Expression Profiling ; Humans ; Immunoprecipitation/trends ; Protein Binding ; RNA Polymerase II/metabolism ; Transcription, Genetic ; Transcriptome
Czasopismo naukowe
Tytuł :
The RNA binding protein FgRbp1 regulates specific pre-mRNA splicing via interacting with U2AF23 in Fusarium.
Autorzy :
Wang M; State Key Laboratory of Rice Biology, the Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Ma T; State Key Laboratory of Rice Biology, the Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Wang H; State Key Laboratory of Rice Biology, the Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Liu J; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
Chen Y; State Key Laboratory of Rice Biology, the Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China. .
Shim WB; Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA. .
Ma Z; State Key Laboratory of Rice Biology, the Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2661. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
Fungal Proteins/*metabolism
Fusarium/*metabolism
RNA Precursors/*metabolism
RNA-Binding Proteins/*metabolism
Splicing Factor U2AF/*metabolism
Base Sequence ; Binding Sites/genetics ; Edible Grain/microbiology ; Fungal Proteins/genetics ; Fusarium/genetics ; Fusarium/pathogenicity ; Humans ; Introns/genetics ; Protein Binding ; RNA Precursors/genetics ; RNA Splice Sites ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; Virulence
Czasopismo naukowe
Tytuł :
The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection.
Autorzy :
Vlachogiannis NI; First Department of Propaedeutic Internal Medicine and Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Verrou KM; Center of New Biotechnologies & Precision Medicine, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Stellos K; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Sfikakis PP; First Department of Propaedeutic Internal Medicine and Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece; Center of New Biotechnologies & Precision Medicine, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Paraskevis D; Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens Medical School, Athens, Greece. Electronic address: .
Pokaż więcej
Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 May; Vol. 226, pp. 108699. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunity, Innate*
RNA Editing*
APOBEC Deaminases/*metabolism
Adenosine Deaminase/*metabolism
COVID-19/*immunology
RNA Viruses/*genetics
RNA-Binding Proteins/*metabolism
SARS-CoV-2/*genetics
APOBEC Deaminases/genetics ; Adenosine Deaminase/genetics ; COVID-19/enzymology ; COVID-19/virology ; Humans ; Mutation ; RNA Viruses/pathogenicity ; RNA, Double-Stranded/metabolism ; RNA-Binding Proteins/genetics ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code.
Autorzy :
Saha K; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
Fernandez MM; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
Biswas T; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
Joseph S; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
Ghosh G; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 09; Vol. 49 (12), pp. 7103-7121.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
RNA Splicing*
RNA Precursors/*chemistry
RNA, Messenger/*chemistry
HeLa Cells ; Humans ; Introns ; Mutation ; Nucleic Acid Conformation ; Protein Domains ; RNA Precursors/metabolism ; RNA Splice Sites ; RNA, Messenger/metabolism ; Ribonucleoprotein, U1 Small Nuclear/metabolism ; Serine-Arginine Splicing Factors/chemistry ; Serine-Arginine Splicing Factors/metabolism ; Splicing Factor U2AF/metabolism
Czasopismo naukowe
Tytuł :
DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination.
Autorzy :
Chakraborty P; Division of Cellular Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Scotland, United Kingdom.
Hiom K; Division of Cellular Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Scotland, United Kingdom. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Jul 05; Vol. 12 (1), pp. 4126. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA*
Homologous Recombination*
RNA*
BRCA1 Protein/*metabolism
DEAD-box RNA Helicases/*metabolism
Neoplasm Proteins/*metabolism
BRCA1 Protein/genetics ; DEAD-box RNA Helicases/genetics ; DNA Damage ; DNA Helicases ; DNA Repair ; DNA Replication ; DNA-Binding Proteins/metabolism ; Humans ; Phthalazines ; Piperazines ; RNA Helicases ; RNA, Messenger ; Rad51 Recombinase ; Recombinational DNA Repair
Czasopismo naukowe
Tytuł :
Human prefoldin modulates co-transcriptional pre-mRNA splicing.
Autorzy :
Payán-Bravo L; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.
Fontalva S; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.
Peñate X; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.
Cases I; Centro Andaluz de Biología del Desarrollo, CSIC-Universidad Pablo de Olavide, Seville, Spain.
Guerrero-Martínez JA; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.
Pareja-Sánchez Y; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.
Odriozola-Gil Y; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.
Lara E; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.
Jimeno-González S; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.
Suñé C; Department of Molecular Biology, Institute of Parasitology and Biomedicine 'López Neyra' IPBLN-CSIC, PTS, Granada, Spain.
Muñoz-Centeno MC; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.
Reyes JC; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.
Chávez S; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario V. del Rocío, Seville, Spain.; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jun 21; Vol. 49 (11), pp. 6267-6280.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
Transcription, Genetic*
Molecular Chaperones/*physiology
RNA, Messenger/*metabolism
Cell Line ; Humans ; Introns ; RNA Polymerase II/metabolism ; RNA Precursors/metabolism ; RNA Splicing Factors/metabolism ; Repressor Proteins/physiology ; Transcriptome
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies