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Tytuł :
tRFtarget: a database for transfer RNA-derived fragment targets.
Autorzy :
Li N; SJTU-Yale Joint Center for Biostatistics and Data Science, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA.
Shan N; Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA.; Center for Statistical Science, Department of Industrial Engineering, Tsinghua University, Beijing 100084, China.
Lu L; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06520, USA.
Wang Z; SJTU-Yale Joint Center for Biostatistics and Data Science, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D254-D260.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Databases, Nucleic Acid*
RNA, Messenger/*genetics
RNA, Small Untranslated/*genetics
RNA, Transfer/*genetics
Animals ; Base Pairing ; Base Sequence ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Gene Ontology ; Humans ; Mice ; Molecular Sequence Annotation ; Nucleic Acid Conformation ; Nucleic Acid Hybridization ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA, Small Untranslated/chemistry ; RNA, Small Untranslated/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; Rhodobacter sphaeroides/genetics ; Rhodobacter sphaeroides/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Thermodynamics ; Xenopus/genetics ; Xenopus/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants.
Autorzy :
Zhao L; Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang J; Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Li Y; Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Song T; Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Wu Y; Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
Fang S; Beijing University of Chinese Medicine, Chaoyang District, Beijing 100029, China.
Bu D; Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
Li H; Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
Sun L; Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
Pei D; State Key Laboratory of Tree Genetics and Breeding, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China.
Zheng Y; Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Huang J; Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang A & F University, Lin'an, Hangzhou 311300, China.
Xu M; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 518102, China.
Chen R; Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Guangdong Geneway Decoding Bio-Tech Co. Ltd, Foshan 528316, China.; National Genomics Data Center, Chinese Academy of Sciences, Beijing 100101, China.
Zhao Y; Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
He S; Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; National Genomics Data Center, Chinese Academy of Sciences, Beijing 100101, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D165-D171.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Databases, Nucleic Acid*
Software*
Transcriptome*
Neoplasms/*genetics
RNA, Long Noncoding/*genetics
RNA, Messenger/*genetics
Animals ; Base Sequence ; Conserved Sequence ; Exons ; Gene Expression Profiling ; Humans ; Internet ; Mice ; Molecular Sequence Annotation ; Neoplasms/classification ; Neoplasms/metabolism ; Neoplasms/pathology ; Plants/genetics ; RNA, Long Noncoding/classification ; RNA, Long Noncoding/metabolism ; RNA, Messenger/classification ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
An RNA pseudoknot is essential for standby-mediated translation of the tisB toxin mRNA in Escherichia coli.
Autorzy :
Romilly C; Department of Cell and Molecular Biology, Uppsala University, Uppsala S-75124, Sweden.
Lippegaus A; Department of Cell and Molecular Biology, Uppsala University, Uppsala S-75124, Sweden.
Wagner EGH; Department of Cell and Molecular Biology, Uppsala University, Uppsala S-75124, Sweden.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 12336-12347.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Bacterial*
Protein Biosynthesis*
Bacterial Toxins/*genetics
Escherichia coli/*genetics
Escherichia coli Proteins/*genetics
RNA, Bacterial/*genetics
RNA, Messenger/*genetics
Toxin-Antitoxin Systems/*genetics
Bacterial Toxins/metabolism ; Base Pairing ; Base Sequence ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Nucleic Acid Conformation ; Point Mutation ; Protein Binding ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Bacterial/chemistry ; RNA, Bacterial/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosome Subunits, Small, Bacterial/genetics ; Ribosome Subunits, Small, Bacterial/metabolism
Czasopismo naukowe
Tytuł :
Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs.
Autorzy :
Pierce JB; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Simion V; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Icli B; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Pérez-Cremades D; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cheng HS; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Feinberg MW; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Genes [Genes (Basel)] 2020 Nov 16; Vol. 11 (11). Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Angiotensin-Converting Enzyme 2/*genetics
Interferons/*genetics
MicroRNAs/*genetics
RNA, Messenger/*genetics
SARS-CoV-2/*genetics
Serine Endopeptidases/*genetics
Angiotensin-Converting Enzyme 2/metabolism ; Computational Biology/methods ; Gene Silencing ; Humans ; Interferons/metabolism ; MicroRNAs/chemistry ; MicroRNAs/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Serine Endopeptidases/metabolism ; Transcriptome ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
ArfB can displace mRNA to rescue stalled ribosomes.
Autorzy :
Carbone CE; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, Massachusetts, 01605, United States.
Demo G; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, Massachusetts, 01605, United States.; Central European Institute of Technology, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic.
Madireddy R; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, Massachusetts, 01605, United States.; Medicago Inc., 7 Triangle drive, Durham, NC, 27713, USA.
Svidritskiy E; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, Massachusetts, 01605, United States. .; Sanofi, 49 New York Ave, Suite 3660, Framingham, MA, 01701, USA. .
Korostelev AA; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, Massachusetts, 01605, United States. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 03; Vol. 11 (1), pp. 5552. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Escherichia coli Proteins/*metabolism
RNA, Messenger/*metabolism
Ribosomes/*metabolism
Biocatalysis ; Dimerization ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/ultrastructure ; Models, Biological ; Protein Conformation ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/ultrastructure ; Ribosome Subunits/metabolism ; Ribosomes/ultrastructure
Czasopismo naukowe
Tytuł :
The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.
Autorzy :
Smith EM; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
Benbahouche NEH; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
Morris K; MRC Toxicology Unit, University of Cambridge, Leicester LE1 9HN, UK.
Wilczynska A; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK.
Gillen S; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
Schmidt T; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
Meijer HA; Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Jukes-Jones R; MRC Toxicology Unit, University of Cambridge, Leicester LE1 9HN, UK.
Cain K; MRC Toxicology Unit, University of Cambridge, Leicester LE1 9HN, UK.
Jones C; MRC Toxicology Unit, University of Cambridge, Leicester LE1 9HN, UK.
Stoneley M; MRC Toxicology Unit, University of Cambridge, Leicester LE1 9HN, UK.
Waldron JA; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
Bell C; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK.
Fonseca BD; PrimerGen Ltd, Viseu, Portugal.
Blagden S; Department of Oncology, University of Oxford, Oxford, OX3 7LE, UK.
Willis AE; MRC Toxicology Unit, University of Cambridge, Leicester LE1 9HN, UK.
Bushell M; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 458-478.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoantigens/*physiology
Poly(A)-Binding Protein I/*physiology
Polyribosomes/*metabolism
Protein Biosynthesis/*physiology
RNA, Messenger/*metabolism
Ribonucleoproteins/*physiology
TOR Serine-Threonine Kinases/*physiology
5' Untranslated Regions/genetics ; Autoantigens/genetics ; Gene Expression Regulation ; Genes, Reporter ; HeLa Cells ; Humans ; Mechanistic Target of Rapamycin Complex 1/antagonists & inhibitors ; Mechanistic Target of Rapamycin Complex 2/antagonists & inhibitors ; Mutagenesis, Site-Directed ; Mutation, Missense ; Naphthyridines/pharmacology ; Point Mutation ; Protein Biosynthesis/genetics ; RNA Interference ; RNA, Messenger/genetics ; RNA-Binding Proteins/isolation & purification ; RNA-Binding Proteins/metabolism ; Recombinant Fusion Proteins/metabolism ; Ribonucleoproteins/genetics
Czasopismo naukowe
Tytuł :
Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.
Autorzy :
Kalinina M; Skolkovo Institute of Science and Technology, Center of Life Sciences, Moscow 143026, Russia.
Skvortsov D; Moscow State University, Faculty of Chemistry, Moscow 119991, Russia.
Kalmykova S; Skolkovo Institute of Science and Technology, Center of Life Sciences, Moscow 143026, Russia.
Ivanov T; Skolkovo Institute of Science and Technology, Center of Life Sciences, Moscow 143026, Russia.
Dontsova O; Skolkovo Institute of Science and Technology, Center of Life Sciences, Moscow 143026, Russia.; Moscow State University, Faculty of Chemistry, Moscow 119991, Russia.
Pervouchine DD; Skolkovo Institute of Science and Technology, Center of Life Sciences, Moscow 143026, Russia.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 479-490.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Conformation*
RNA Folding*
Alternative Splicing/*genetics
Aminoacyltransferases/*genetics
Oligonucleotides/*pharmacology
Oligonucleotides, Antisense/*pharmacology
RNA Precursors/*genetics
RNA, Messenger/*genetics
A549 Cells ; Base Sequence ; Cell Line, Tumor ; Conserved Sequence ; Exons/genetics ; Gene Expression Regulation/drug effects ; Humans ; Introns/genetics ; Mutagenesis, Site-Directed ; Neoplasm Proteins/genetics ; Oligonucleotides/genetics ; Oligonucleotides, Antisense/genetics ; Organ Specificity ; RNA, Messenger/metabolism ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Transcription Elongation, Genetic
Czasopismo naukowe
Tytuł :
MeDAS: a Metazoan Developmental Alternative Splicing database.
Autorzy :
Li Z; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Zhang Y; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Bush SJ; Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, UK.
Tang C; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Chen L; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Zhang D; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Urrutia AO; Instituto de Ecologia, UNAM, Ciudad de Mexico 04510, Mexico.; Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
Lin JW; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Chen L; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu 610041, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D144-D150.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Databases, Genetic*
Gene Expression Regulation, Developmental*
Genome*
Transcriptome*
RNA, Messenger/*genetics
Amphibians/genetics ; Amphibians/growth & development ; Amphibians/metabolism ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans/metabolism ; Cephalochordata/genetics ; Cephalochordata/growth & development ; Cephalochordata/metabolism ; Exons ; High-Throughput Nucleotide Sequencing ; Humans ; Internet ; Introns ; Mammals/genetics ; Mammals/growth & development ; Mammals/metabolism ; RNA, Messenger/metabolism ; Reptiles/genetics ; Reptiles/growth & development ; Reptiles/metabolism ; Software ; Urochordata/genetics ; Urochordata/growth & development ; Urochordata/metabolism ; Zebrafish/genetics ; Zebrafish/growth & development ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome.
Autorzy :
Tang Y; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L7 8TX Liverpool, UK.
Chen K; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.; Institute of Ageing & Chronic Disease, University of Liverpool, L7 8TX Liverpool, UK.
Song B; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L7 8TX Liverpool, UK.; Department of Mathematical Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.
Ma J; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.
Wu X; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.; Institute of Ageing & Chronic Disease, University of Liverpool, L7 8TX Liverpool, UK.
Xu Q; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.
Wei Z; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.
Su J; Department of Mathematical Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.
Liu G; Department of Mathematical Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.
Rong R; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L7 8TX Liverpool, UK.
Lu Z; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L7 8TX Liverpool, UK.
de Magalhães JP; Institute of Ageing & Chronic Disease, University of Liverpool, L7 8TX Liverpool, UK.
Rigden DJ; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L7 8TX Liverpool, UK.
Meng J; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L7 8TX Liverpool, UK.; AI University Research Centre, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D134-D143.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Knowledge Bases*
Transcriptome*
Adenosine/*analogs & derivatives
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
RNA, Messenger/*genetics
Adenosine/metabolism ; Animals ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Atlases as Topic ; Datasets as Topic ; Dengue Virus/genetics ; Dengue Virus/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; HIV/genetics ; HIV/metabolism ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/metabolism ; Humans ; Mice ; MicroRNAs/metabolism ; Pan troglodytes/genetics ; Pan troglodytes/metabolism ; RNA, Long Noncoding/metabolism ; RNA, Messenger/metabolism ; Rats ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Swine ; Zebrafish
Czasopismo naukowe
Tytuł :
cncRNAdb: a manually curated resource of experimentally supported RNAs with both protein-coding and noncoding function.
Autorzy :
Huang Y; Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528308, China.
Wang J; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Zhao Y; School of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Hangzhou 310053, China.
Wang H; Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528308, China.
Liu T; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Li Y; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Cui T; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Li W; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Feng Y; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Luo J; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Gong J; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Ning L; Dermatology Hospital, Southern Medical University, Guangzhou 510091, China.
Zhang Y; Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528308, China.
Wang D; Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528308, China.; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.; Dermatology Hospital, Southern Medical University, Guangzhou 510091, China.
Zhang Y; Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528308, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D65-D70.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Nucleic Acid/*organization & administration
MicroRNAs/*genetics
RNA, Circular/*genetics
RNA, Long Noncoding/*genetics
RNA, Messenger/*genetics
RNA, Ribosomal/*genetics
RNA, Small Interfering/*genetics
RNA, Transfer/*genetics
3' Untranslated Regions ; 5' Untranslated Regions ; Animals ; Drosophila melanogaster/genetics ; Humans ; Mice ; MicroRNAs/classification ; Pan troglodytes/genetics ; RNA, Circular/classification ; RNA, Long Noncoding/classification ; RNA, Messenger/classification ; RNA, Ribosomal/classification ; RNA, Small Interfering/classification ; RNA, Transfer/classification ; Software ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
DIGGER: exploring the functional role of alternative splicing in protein interactions.
Autorzy :
Louadi Z; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany.
Yuan K; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany.
Gress A; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany.
Tsoy O; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany.
Kalinina OV; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany.; Faculty of Medicine, Saarland University, 66421 Homburg, Germany.
Baumbach J; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany.; Department of Mathematics and Computer Science, University of Southern Denmark, 5230 Odense M, Denmark.
Kacprowski T; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany.
List M; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D309-D318.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Databases, Protein*
Exons*
Protein Interaction Mapping/*methods
Proteome/*chemistry
RNA, Messenger/*genetics
Binding Sites ; Computational Biology/methods ; Humans ; Internet ; Models, Molecular ; Protein Binding ; Protein Biosynthesis ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Isoforms ; Proteome/genetics ; Proteome/metabolism ; RNA, Messenger/metabolism ; Software ; Thermodynamics
Czasopismo naukowe
Tytuł :
RJunBase: a database of RNA splice junctions in human normal and cancerous tissues.
Autorzy :
Li Q; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Lai H; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Li Y; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Chen B; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Chen S; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Li Y; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Huang Z; Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, China.
Meng Z; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Wang P; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Hu Z; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Huang S; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D201-D211.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Databases, Nucleic Acid*
Gene Expression Regulation, Neoplastic*
RNA Splice Sites*
Neoplasms/*genetics
RNA, Messenger/*genetics
Exons ; Gene Expression Profiling ; Humans ; Internet ; Introns ; Neoplasms/diagnosis ; Neoplasms/mortality ; Neoplasms/pathology ; RNA, Messenger/metabolism ; Sequence Analysis, RNA ; Software ; Survival Analysis
Czasopismo naukowe
Tytuł :
RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics?
Autorzy :
Sandbrink JB; Medical School, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Shattock RJ; Department of Infectious Diseases, Imperial College London, London, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 22; Vol. 11, pp. 608460. Date of Electronic Publication: 2020 Dec 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
RNA, Messenger*
Vaccines, DNA*
Pandemics/*prevention & control
Animals ; Humans
Czasopismo naukowe
Tytuł :
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Autorzy :
Yuan S; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
Peng L; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Systems Biology Institute, Yale University, West Haven, CT 06516, USA.
Park JJ; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Systems Biology Institute, Yale University, West Haven, CT 06516, USA.
Hu Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
Devarkar SC; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
Dong MB; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Systems Biology Institute, Yale University, West Haven, CT 06516, USA.
Shen Q; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
Wu S; Department of Pharmacology, Yale University, West Haven, CT 06516, USA.
Chen S; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Systems Biology Institute, Yale University, West Haven, CT 06516, USA. Electronic address: .
Lomakin IB; Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: .
Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Dec 17; Vol. 80 (6), pp. 1055-1066.e6. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Protein Biosynthesis*
COVID-19/*metabolism
RNA, Messenger/*metabolism
RNA, Viral/*metabolism
SARS-CoV-2/*metabolism
SARS-CoV-2/*pathogenicity
Viral Nonstructural Proteins/*metabolism
Animals ; COVID-19/genetics ; COVID-19/pathology ; Chlorocebus aethiops ; Cryoelectron Microscopy ; Humans ; RNA, Messenger/genetics ; RNA, Viral/genetics ; Ribosome Subunits, Small, Eukaryotic/genetics ; Ribosome Subunits, Small, Eukaryotic/metabolism ; Ribosome Subunits, Small, Eukaryotic/ultrastructure ; Ribosome Subunits, Small, Eukaryotic/virology ; SARS-CoV-2/genetics ; SARS-CoV-2/ultrastructure ; Vero Cells ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2.
Autorzy :
Hassert M; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Geerling E; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Stone ET; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Steffen TL; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Feldman MS; Department of Biomedical Engineering, Saint Louis University, St. Louis, Missouri, United States of America.
Dickson AL; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Class J; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, United States of America.
Richner JM; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, United States of America.
Brien JD; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Pinto AK; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Dec 16; Vol. 16 (12), pp. e1009163. Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Adaptive Immunity/*immunology
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*immunology
RNA, Messenger/*metabolism
SARS-CoV-2/*immunology
T-Lymphocytes/*immunology
Angiotensin-Converting Enzyme 2/genetics ; Animals ; COVID-19/metabolism ; COVID-19/virology ; Chlorocebus aethiops ; Epitopes, T-Lymphocyte/immunology ; Humans ; Mice ; Mice, Knockout ; Mice, Transgenic ; RNA, Messenger/genetics ; Receptor, Interferon alpha-beta/physiology ; T-Lymphocytes/virology ; Vero Cells
Czasopismo naukowe
Tytuł :
High resolution biosensor to test the capping level and integrity of mRNAs.
Autorzy :
Moya-Ramírez I; Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK.; Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.
Bouton C; Department of Infectious Disease, Imperial College London, London W2 1NY, UK.
Kontoravdi C; Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK.
Polizzi K; Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK.; Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 16; Vol. 48 (22), pp. e129.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biosensing Techniques*
Transcription, Genetic*
RNA Caps/*genetics
RNA, Messenger/*isolation & purification
Protein Biosynthesis/genetics ; RNA Stability ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
RNA structure-wide discovery of functional interactions with multiplexed RNA motif library.
Autorzy :
Komatsu KR; Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan.
Taya T; Twist Bioscience, 681 Gateway Blvd South, San Francisco, CA, 94080, USA.
Matsumoto S; Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan.
Miyashita E; Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan.
Kashida S; Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan. .
Saito H; Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 08; Vol. 11 (1), pp. 6275. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G-Quadruplexes*
MicroRNAs/*metabolism
Protein Biosynthesis/*genetics
RNA Precursors/*metabolism
RNA, Messenger/*metabolism
5' Untranslated Regions/genetics ; Computer Simulation ; Datasets as Topic ; Electrophoretic Mobility Shift Assay ; Eukaryotic Initiation Factor-3/metabolism ; Gene Library ; Genome, Viral/genetics ; HEK293 Cells ; HIV-1/genetics ; Humans ; MicroRNAs/ultrastructure ; Nucleotide Motifs ; Proof of Concept Study ; Protein Binding/genetics ; RNA Folding/genetics ; RNA Precursors/ultrastructure ; RNA, Messenger/ultrastructure ; RNA, Viral/metabolism ; RNA, Viral/ultrastructure ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Post-transcriptional control of cellular differentiation by the RNA exosome complex.
Autorzy :
Fraga de Andrade I; Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 4009 WIMR, Madison, WI 53705, USA.
Mehta C; Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 4009 WIMR, Madison, WI 53705, USA.
Bresnick EH; Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 4009 WIMR, Madison, WI 53705, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 11913-11928.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Protein Processing, Post-Translational*
Chromatin/*chemistry
Erythrocytes/*metabolism
Exosome Multienzyme Ribonuclease Complex/*metabolism
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Animals ; Cell Differentiation ; Chromatin/metabolism ; Chromatin/ultrastructure ; DNA Repair ; Erythrocytes/ultrastructure ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosome Multienzyme Ribonuclease Complex/ultrastructure ; Genomic Instability ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/ultrastructure ; Humans ; Mice ; Organ Specificity ; Protein Subunits/genetics ; Protein Subunits/metabolism ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
RiboDiPA: a novel tool for differential pattern analysis in Ribo-seq data.
Autorzy :
Li K; Department of Statistics, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.; NSF-Simons Center for Quantitative Biology, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.
Hope CM; NSF-Simons Center for Quantitative Biology, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.; Department of Molecular Biosciences, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.
Wang XA; NSF-Simons Center for Quantitative Biology, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.; Department of Molecular Biosciences, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.
Wang JP; Department of Statistics, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.; NSF-Simons Center for Quantitative Biology, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 12016-12029.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Fungal*
Protein Biosynthesis*
Software*
RNA, Fungal/*genetics
RNA, Messenger/*genetics
Ribosomes/*genetics
Saccharomyces cerevisiae/*genetics
Base Sequence ; Benchmarking ; Codon/chemistry ; Codon/metabolism ; High-Throughput Nucleotide Sequencing ; RNA, Fungal/metabolism ; RNA, Messenger/metabolism ; Ribosomes/metabolism ; Saccharomyces cerevisiae/metabolism ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases.
Autorzy :
Jansen Y; Department of Medical Oncology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium. .
Kruse V; Department of Medical Oncology, Universitair Ziekenhuis Gent (UZ Gent), Ghent, Belgium.
Corthals J; Laboratory of Molecular and Cellular Therapy and Dendritic Cell-bank, Vrije Universiteit Brussel, Brussels, Belgium.
Schats K; Histogenex NV, Antwerp, Belgium.
van Dam PJ; Histogenex NV, Antwerp, Belgium.
Seremet T; Department of Medical Oncology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
Heirman C; Laboratory of Molecular and Cellular Therapy and Dendritic Cell-bank, Vrije Universiteit Brussel, Brussels, Belgium.
Brochez L; Department of Medical Oncology, Universitair Ziekenhuis Gent (UZ Gent), Ghent, Belgium.
Kockx M; Histogenex NV, Antwerp, Belgium.
Thielemans K; Laboratory of Molecular and Cellular Therapy and Dendritic Cell-bank, Vrije Universiteit Brussel, Brussels, Belgium.
Neyns B; Department of Medical Oncology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Dec; Vol. 69 (12), pp. 2589-2598. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms :
Dendritic Cells/*transplantation
Melanoma/*therapy
Neoplasm Recurrence, Local/*epidemiology
RNA, Messenger/*immunology
Skin Neoplasms/*therapy
Adult ; Aged ; Aged, 80 and over ; CD27 Ligand/genetics ; CD27 Ligand/immunology ; CD40 Ligand/genetics ; CD40 Ligand/immunology ; Combined Modality Therapy/methods ; Dendritic Cells/metabolism ; Disease-Free Survival ; Electroporation ; Female ; Follow-Up Studies ; Humans ; Immunotherapy/methods ; Male ; Melanoma/immunology ; Melanoma/mortality ; Melanoma/secondary ; Middle Aged ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Staging ; RNA, Messenger/genetics ; Skin Neoplasms/immunology ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Surgical Procedures, Operative ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology ; Transplantation, Autologous/methods ; Young Adult
Czasopismo naukowe

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