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Wyszukujesz frazę ""RNA, Messenger"" wg kryterium: Temat


Tytuł :
Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases.
Autorzy :
Elkhalifa D; Department of Pharmacy, Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.
Rayan M; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar.
Negmeldin AT; Department of Pharmaceutical Sciences, College of Pharmacy and Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Elhissi A; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar; Office of the Vice President for Research and Graduate Studies, Qatar University, Doha, Qatar.
Khalil A; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Jan; Vol. 145, pp. 112385. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Vaccines, Synthetic*/administration & dosage
Vaccines, Synthetic*/immunology
mRNA Vaccines*/administration & dosage
mRNA Vaccines*/immunology
COVID-19/*prevention & control
Chronic Disease/*prevention & control
Chronic Disease/*therapy
Genetic Therapy/*methods
Immunotherapy/*methods
Pandemics/*prevention & control
RNA, Messenger/*chemistry
SARS-CoV-2/*immunology
Biological Availability ; Drug Carriers ; Forecasting ; Gene Transfer Techniques ; Genetic Vectors/administration & dosage ; Genetic Vectors/therapeutic use ; Humans ; Immunotherapy, Active ; Nanoparticle Drug Delivery System ; RNA Stability ; RNA, Messenger/administration & dosage ; RNA, Messenger/immunology ; RNA, Messenger/therapeutic use ; SARS-CoV-2/genetics ; Vaccine Development
Czasopismo naukowe
Tytuł :
A working model for condensate RNA-binding proteins as matchmakers for protein complex assembly.
Autorzy :
Chen X; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Mayr C; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2022 Jan; Vol. 28 (1), pp. 76-87. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biomolecular Condensates/*chemistry
Molecular Chaperones/*chemistry
RNA, Messenger/*chemistry
RNA-Binding Proteins/*chemistry
Ribonucleoproteins/*chemistry
Binding Sites ; Biomolecular Condensates/metabolism ; Cytoplasm/chemistry ; Cytoplasm/metabolism ; Eukaryota ; Eukaryotic Cells/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Protein Aggregates ; Protein Binding ; Protein Biosynthesis ; Protein Folding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Are stress granules the RNA analogs of misfolded protein aggregates?
Autorzy :
Ripin N; Department of Biochemistry and Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado 80303, USA.
Parker R; Department of Biochemistry and Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado 80303, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2022 Jan; Vol. 28 (1), pp. 67-75. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biomolecular Condensates/*chemistry
Heat-Shock Proteins/*chemistry
Molecular Chaperones/*chemistry
RNA, Messenger/*chemistry
Ribonucleoproteins/*chemistry
Stress Granules/*chemistry
Biomolecular Condensates/metabolism ; Eukaryota ; Eukaryotic Cells/metabolism ; Eukaryotic Initiation Factor-4A/chemistry ; Eukaryotic Initiation Factor-4A/genetics ; Eukaryotic Initiation Factor-4A/metabolism ; Flocculation ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Peptide Chain Initiation, Translational ; Protein Aggregates ; Protein Folding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Stress Granules/genetics ; Stress Granules/metabolism
Czasopismo naukowe
Tytuł :
Design considerations for analyzing protein translation regulation by condensates.
Autorzy :
Roden CA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA.
Gladfelter AS; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2022 Jan; Vol. 28 (1), pp. 88-96. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Biomolecular Condensates/*chemistry
Genetic Engineering/*methods
RNA, Messenger/*chemistry
RNA-Binding Proteins/*chemistry
Ribonucleoproteins/*chemistry
Binding Sites ; Biomolecular Condensates/metabolism ; Eukaryota ; Eukaryotic Cells/metabolism ; Fluorescent Antibody Technique/methods ; Genes, Reporter ; Protein Binding ; Protein Biosynthesis ; Protein Folding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning.
Autorzy :
Carmody PJ; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Zimmer MH; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Kuntz CP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Harrington HR; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Duckworth KE; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Penn WD; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Mukhopadhyay S; Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Miller TF; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Schlebach JP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Dec 16; Vol. 49 (22), pp. 12943-12954.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Molecular Dynamics Simulation*
Frameshifting, Ribosomal/*genetics
Protein Biosynthesis/*genetics
RNA, Messenger/*genetics
Ribosomes/*genetics
Alphavirus/genetics ; Alphavirus/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Mutation ; Nucleic Acid Conformation ; Polyproteins/genetics ; Polyproteins/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; RNA, Viral/chemistry ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members.
Autorzy :
Adamopoulos PG; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Tsiakanikas P; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Boti MA; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Scorilas A; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 10; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
Gene Expression Profiling*
Neoplasm Proteins*/biosynthesis
Neoplasm Proteins*/genetics
Neoplasms*/enzymology
Neoplasms*/genetics
RNA, Messenger*/biosynthesis
RNA, Messenger*/genetics
RNA, Neoplasm*/biosynthesis
RNA, Neoplasm*/genetics
ras Proteins*/biosynthesis
ras Proteins*/genetics
Cell Line, Tumor ; Humans ; Nanopore Sequencing
Czasopismo naukowe
Tytuł :
Antisense oligonucleotide repress telomerase activity via manipulating alternative splicing or translation.
Autorzy :
Zhou J; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Li T; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Geng X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Sui L; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China. Electronic address: .
Wang F; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Dec 10; Vol. 582, pp. 118-124. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Morpholinos/*genetics
Oligonucleotides, Antisense/*genetics
Phosphorothioate Oligonucleotides/*genetics
RNA, Messenger/*genetics
Telomerase/*genetics
Alternative Splicing/drug effects ; Antineoplastic Agents/pharmacology ; HEK293 Cells ; HeLa Cells ; Humans ; Morpholinos/chemical synthesis ; Morpholinos/metabolism ; Oligonucleotides, Antisense/chemical synthesis ; Oligonucleotides, Antisense/metabolism ; Phosphorothioate Oligonucleotides/chemical synthesis ; Phosphorothioate Oligonucleotides/metabolism ; Protein Biosynthesis/drug effects ; RNA, Messenger/antagonists & inhibitors ; RNA, Messenger/metabolism ; Telomerase/antagonists & inhibitors ; Telomerase/metabolism
Czasopismo naukowe
Tytuł :
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Autorzy :
Poetz F; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, 69120, Heidelberg, Germany.
Corbo J; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD, 21702-1201, USA.
Levdansky Y; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD, 21702-1201, USA.
Spiegelhalter A; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, 69120, Heidelberg, Germany.
Lindner D; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, 69120, Heidelberg, Germany.
Magg V; Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, 69120, Heidelberg, Germany.
Lebedeva S; Berlin Institute for Molecular Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine, 10115, Berlin, Germany.
Schweiggert J; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, 69120, Heidelberg, Germany.
Schott J; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, 69120, Heidelberg, Germany.
Valkov E; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD, 21702-1201, USA. .
Stoecklin G; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany. .; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, 69120, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Dec 09; Vol. 12 (1), pp. 7175. Date of Electronic Publication: 2021 Dec 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA, Messenger/*metabolism
Receptors, CCR4/*metabolism
Transcription Factors/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Adenosine Monophosphate/metabolism ; HeLa Cells ; Humans ; Protein Binding ; RNA Stability ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Receptors, CCR4/genetics ; Transcription Factors/genetics ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Antibody Titers Before and After a Third Dose of the SARS-CoV-2 BNT162b2 Vaccine in Adults Aged ≥60 Years.
Autorzy :
Eliakim-Raz N; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Leibovici-Weisman Y; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Stemmer A; Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel.
Ness A; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Awwad M; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Ghantous N; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
Stemmer SM; Rabin Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel.
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Źródło :
JAMA [JAMA] 2021 Dec 07; Vol. 326 (21), pp. 2203-2204.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Viral/*blood
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
Immunoglobulin G/*blood
RNA, Messenger/*immunology
RNA, Viral/*immunology
SARS-CoV-2/*immunology
Aged ; Aged, 80 and over ; Antibodies, Viral/immunology ; BNT162 Vaccine ; COVID-19/immunology ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Female ; Humans ; Immunoglobulin G/immunology ; Male ; Middle Aged ; RNA, Messenger/administration & dosage ; RNA, Messenger/blood ; RNA, Viral/administration & dosage ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Lipid Nanoparticle-mRNA Formulations for Therapeutic Applications.
Autorzy :
Wang C; Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Zhang Y; Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Dong Y; Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.; Department of Biomedical Engineering, The Center for Clinical and Translational Science, The Comprehensive Cancer Center, Dorothy M. Davis Heart & Lung Research Institute, Department of Radiation Oncology, The Ohio State University, Columbus, Ohio 43210, United States.
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Źródło :
Accounts of chemical research [Acc Chem Res] 2021 Dec 07; Vol. 54 (23), pp. 4283-4293. Date of Electronic Publication: 2021 Nov 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Carriers/*chemistry
Liposomes/*chemistry
Nanoparticles/*chemistry
RNA, Messenger/*chemistry
Animals ; Benzamides/chemistry ; Biomimetic Materials/chemistry ; Communicable Diseases/immunology ; Communicable Diseases/therapy ; Disease Models, Animal ; Genetic Diseases, Inborn/immunology ; Genetic Diseases, Inborn/therapy ; Humans ; Mice ; Neoplasms/immunology ; Neoplasms/therapy ; Phospholipids/chemistry ; RNA, Messenger/metabolism ; RNA, Messenger/therapeutic use ; Untranslated Regions ; Vitamins/chemistry
Czasopismo naukowe
Tytuł :
Carbon starvation-induced synthesis of GDH2 and PEPCK is essential for the survival of Pichia pastoris.
Autorzy :
Dey T; Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India.
Rangarajan PN; Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Dec 03; Vol. 581, pp. 25-30. Date of Electronic Publication: 2021 Oct 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbon/*deficiency
Fungal Proteins/*genetics
Glutamate Dehydrogenase (NADP+)/*genetics
Phosphoenolpyruvate Carboxykinase (ATP)/*genetics
RNA, Messenger/*genetics
Saccharomycetales/*drug effects
Amino Acids/metabolism ; Autophagy/genetics ; Autophagy-Related Proteins ; Carbon/pharmacology ; Fungal Proteins/agonists ; Fungal Proteins/biosynthesis ; Gene Expression Regulation, Fungal ; Glutamate Dehydrogenase (NADP+)/biosynthesis ; Metabolism/genetics ; Microbial Viability ; Phosphoenolpyruvate Carboxykinase (ATP)/biosynthesis ; Protein Biosynthesis ; RNA, Messenger/agonists ; RNA, Messenger/biosynthesis ; Saccharomycetales/enzymology ; Saccharomycetales/genetics ; Saccharomycetales/growth & development
SCR Organism :
Komagataella pastoris
Czasopismo naukowe
Tytuł :
The functions of fluoxetine and identification of fluoxetine-mediated circular RNAs and messenger RNAs in cerebral ischemic stroke.
Autorzy :
He Y; Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Zhang H; Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Deng J; Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Cai Z; Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Gu M; Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Zhao C; Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Guo Y; Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2364-2376.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ischemic Stroke*/blood
Ischemic Stroke*/genetics
Ischemic Stroke*/metabolism
RNA, Circular*/blood
RNA, Circular*/genetics
RNA, Messenger*/blood
RNA, Messenger*/genetics
Fluoxetine/*pharmacology
Animals ; Cerebral Cortex/drug effects ; High-Throughput Nucleotide Sequencing ; Infarction, Middle Cerebral Artery/blood ; Infarction, Middle Cerebral Artery/genetics ; Infarction, Middle Cerebral Artery/metabolism ; Rats ; Sequence Analysis, RNA ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Alterations of long non-coding RNA and mRNA profiles associated with extracellular matrix homeostasis and vascular aging in rats.
Autorzy :
Li Q; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China.
Xiao Z; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China.
Wang Y; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China.
Liu X; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China.
Liu H; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China.
Luo Z; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China.
Zheng S; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 832-843.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Extracellular Matrix*/genetics
Extracellular Matrix*/metabolism
RNA, Long Noncoding*/analysis
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
RNA, Messenger*/analysis
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
Aging/*genetics
Transcriptome/*genetics
Animals ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Homeostasis/genetics ; Male ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas.
Autorzy :
Zou D; Department of Radiology, The First Hospital of Qinhuangdao , Qinhuangdao, Hebei, China.
Wang Y; Department of MRI, The Third Hospital of Qinhuangdao , Qinhuangdao, Hebei, China.
Wang M; Department of Clinical Laboratory, The First Hospital of Qinhuangdao , Qinhuangdao, Hebei, China.
Zhao B; Department of Radiology, The First Hospital of Qinhuangdao , Qinhuangdao, Hebei, China.
Hu F; Department of Radiology, The First Hospital of Qinhuangdao , Qinhuangdao, Hebei, China.
Li Y; Department of Radiology, The First Hospital of Qinhuangdao , Qinhuangdao, Hebei, China.
Zhang B; Department of Radiology, The First Hospital of Qinhuangdao , Qinhuangdao, Hebei, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 496-506.
Typ publikacji :
Journal Article
MeSH Terms :
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
RNA, Untranslated*/genetics
RNA, Untranslated*/metabolism
Sarcoma*/diagnosis
Sarcoma*/genetics
Sarcoma*/metabolism
Tumor Microenvironment/*genetics
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Computational Biology ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Protein Interaction Maps/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming.
Autorzy :
Hansen CB; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jarlhelt I; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hasselbalch RB; Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Emergency medicine, Herlev and Gentofte Hospital, University of Copenhagen, Denmark.
Hamm SR; Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Fogh K; Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Emergency medicine, Herlev and Gentofte Hospital, University of Copenhagen, Denmark.
Pries-Heje MM; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Møller DL; Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Heftdal LD; Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Haematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Pérez-Alós L; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Sørensen E; Department of Clinical Immunology, Section 2034, Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Larsen MAH; Department of Clinical Immunology, Section 2034, Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Skjoedt MO; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ostrowski SR; Department of Clinical Immunology, Section 2034, Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Frikke-Schmidt R; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bayarri-Olmos R; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hilsted LM; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bundgaard H; Department of Haematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nielsen SD; Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Iversen KK; Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Emergency medicine, Herlev and Gentofte Hospital, University of Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Garred P; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
Journal of internal medicine [J Intern Med] 2021 Dec; Vol. 290 (6), pp. 1272-1274. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Letter
MeSH Terms :
Antibodies, Neutralizing*
Antibodies, Viral/*immunology
COVID-19/*immunology
COVID-19/*prevention & control
COVID-19 Vaccines/*immunology
RNA, Messenger/*immunology
SARS-CoV-2/*immunology
Antibody Formation ; BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/genetics ; Denmark ; Health Personnel ; Humans ; Immunogenicity, Vaccine ; Immunoglobulin G/immunology ; RNA, Messenger/administration & dosage ; RNA, Messenger/genetics ; SARS-CoV-2/genetics
Opinia redakcyjna
Tytuł :
Identification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer.
Autorzy :
Wang J; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Zhang C; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 898-913.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA, Messenger*/analysis
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
RNA, Untranslated*/analysis
RNA, Untranslated*/genetics
RNA, Untranslated*/metabolism
Uterine Cervical Neoplasms*/genetics
Uterine Cervical Neoplasms*/metabolism
Uterine Cervical Neoplasms*/mortality
Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Gene Regulatory Networks/genetics ; Humans ; Prognosis
Czasopismo naukowe
Tytuł :
Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.
Autorzy :
Li Y; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA.
Li J; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA.
Wang J; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA.
Lynch DR; Division of Neurology and Pediatrics, Children's Hospital of Philadelphia, Abramson Research Center, Room 502, Philadelphia, PA 19104, USA.
Shen X; Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Corey DR; Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Parekh D; Translate Bio, 29 Hartwell Avenue, Lexington, MA 02421, USA.
Bhat B; Translate Bio, 29 Hartwell Avenue, Lexington, MA 02421, USA.
Woo C; Translate Bio, 29 Hartwell Avenue, Lexington, MA 02421, USA.
Cherry JJ; Translate Bio, 29 Hartwell Avenue, Lexington, MA 02421, USA.
Napierala JS; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA.
Napierala M; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Nov 18; Vol. 49 (20), pp. 11560-11574.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Stability*
Friedreich Ataxia/*therapy
Genetic Therapy/*methods
Iron-Binding Proteins/*genetics
RNA, Messenger/*metabolism
3' Untranslated Regions ; 5' Untranslated Regions ; Cells, Cultured ; Humans ; Iron-Binding Proteins/metabolism ; Oligonucleotides, Antisense/chemistry ; Oligonucleotides, Antisense/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
TERA-Seq: true end-to-end sequencing of native RNA molecules for transcriptome characterization.
Autorzy :
Ibrahim F; Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Oppelt J; Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maragkakis M; Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Mourelatos Z; Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Nov 18; Vol. 49 (20), pp. e115.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Transcriptome*
RNA, Messenger/*genetics
Sequence Analysis, RNA/*methods
HeLa Cells ; Humans ; Polyadenylation ; RNA Splicing ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Sequence Analysis, RNA/standards
Czasopismo naukowe
Tytuł :
Identification of Potential Long Non-Coding RNA Candidates that Contribute to Triple-Negative Breast Cancer in Humans through Computational Approach.
Autorzy :
Rahman MM; Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh.; Department of Chemistry, Binghamton University, State University of New York, Vestal, New York, NY 13902, USA.
Hossain MT; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing 100049, China.; Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Department of Statistics, Bangabandhu Sheikh Mujibur Rahaman Science and Technology University, Gopalganj 8100, Bangladesh.
Reza MS; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing 100049, China.; Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Peng Y; Department of Pathology, The Shenzhen University School of Medicine, Shenzhen 518060, China.
Feng S; Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Wei Y; Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 16; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
RNA, Messenger/*genetics
RNA, Neoplasm/*genetics
Triple Negative Breast Neoplasms/*genetics
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Computational Biology/methods ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Mammary Glands, Human/metabolism ; Mammary Glands, Human/pathology ; MicroRNAs/classification ; MicroRNAs/metabolism ; Molecular Sequence Annotation ; RNA, Long Noncoding/classification ; RNA, Long Noncoding/metabolism ; RNA, Messenger/classification ; RNA, Messenger/metabolism ; RNA, Neoplasm/classification ; RNA, Neoplasm/metabolism ; Triple Negative Breast Neoplasms/diagnosis ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers.
Autorzy :
Zhang D; Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Atochina-Vasserman EN; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Maurya DS; Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Liu M; Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Xiao Q; Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Lu J; Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Lauri G; Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Ona N; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Reagan EK; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ni H; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Weissman D; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Percec V; Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Nov 03; Vol. 143 (43), pp. 17975-17982. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendrimers/*chemistry
RNA, Messenger/*chemistry
Amines/chemistry ; Animals ; Esters/chemistry ; Hydrophobic and Hydrophilic Interactions ; Ions/chemistry ; Mice ; Nanoparticles/chemistry ; RNA, Messenger/immunology ; RNA, Messenger/metabolism ; Vaccines, Synthetic/chemistry ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/metabolism
Czasopismo naukowe

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