Temat: "RNA, Small Interfering" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Autorzy:: Datta D; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Theile CS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Wassarman K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Racie T; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Schmidt K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Sigel R; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Janas MM; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .
Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.
Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. .; Pokaż więcej
Źródło:: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 May 23; Vol. 59 (42), pp. 6347-6350. Date of Electronic Publication: 2023 May 23.
Typ publikacji:: Journal Article
MeSH Terms:: RNA, Small Interfering*/chemistry
RNA-Induced Silencing Complex*/genetics
RNA-Induced Silencing Complex*/metabolism
Animals ; Mice ; Morpholinos/chemistry

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Skocz do pozycji: 2.

Tytuł:: From a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis.
Autorzy:: Yogev O; Eleven Therapeutics, Cambridge, United Kingdom. .
Weissbrod O; Eleven Therapeutics, Tel-Aviv, Israel.
Battistoni G; Eleven Therapeutics, Cambridge, United Kingdom.; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Bressan D; Eleven Therapeutics, Cambridge, United Kingdom.; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Naamati A; Eleven Therapeutics, Cambridge, United Kingdom.
Falciatori I; Eleven Therapeutics, Cambridge, United Kingdom.
Berkyurek AC; Eleven Therapeutics, Cambridge, United Kingdom.
Rasnic R; Eleven Therapeutics, Tel-Aviv, Israel.
Izuagbe R; University of Cambridge, Department of Pathology, Division of Virology, Cambridge, United Kingdom.
Hosmillo M; University of Cambridge, Department of Pathology, Division of Virology, Cambridge, United Kingdom.
Ilan S; Eleven Therapeutics, Tel-Aviv, Israel.
Grossman I; Eleven Therapeutics, Cambridge, MA, USA.
McCormick L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Honeycutt CC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Johnston T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Gagne M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Goodfellow I; University of Cambridge, Department of Pathology, Division of Virology, Cambridge, United Kingdom.
Hannon GJ; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Erlich Y; Eleven Therapeutics, Tel-Aviv, Israel.; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2023 Mar 16; Vol. 6 (1), pp. 277. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: COVID-19*/prevention & control
RNA, Small Interfering*/genetics
RNA, Small Interfering*/therapeutic use
SARS-CoV-2*/genetics
Animals ; Cricetinae ; Administration, Intranasal ; Mesocricetus ; RNA Interference

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Skocz do pozycji: 3.

Tytuł:: Sequence determinant of small RNA production by DICER.
Autorzy:: Lee YY; Center for RNA Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.; School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Kim H; Center for RNA Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.; School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Kim VN; Center for RNA Research, Institute for Basic Science (IBS), Seoul, Republic of Korea. .; School of Biological Sciences, Seoul National University, Seoul, Republic of Korea. .; Pokaż więcej
Źródło:: Nature [Nature] 2023 Mar; Vol. 615 (7951), pp. 323-330. Date of Electronic Publication: 2023 Feb 22.
Typ publikacji:: Journal Article
MeSH Terms:: DEAD-box RNA Helicases*/metabolism
MicroRNAs*/biosynthesis
MicroRNAs*/genetics
MicroRNAs*/metabolism
Ribonuclease III*/metabolism
RNA, Small Interfering*/biosynthesis
RNA, Small Interfering*/genetics
RNA, Small Interfering*/metabolism
RNA Precursors*/biosynthesis
RNA Precursors*/chemistry
RNA Precursors*/genetics
RNA Precursors*/metabolism
Nucleic Acid Conformation*
Humans ; Base Pairing ; RNA Interference ; RNA, Double-Stranded/chemistry ; RNA, Double-Stranded/genetics ; RNA, Double-Stranded/metabolism ; Base Sequence

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Skocz do pozycji: 4.

Tytuł:: Unusual suspects in flower color evolution.
Autorzy:: Monniaux M; Laboratoire de Reproduction et Développement des Plantes, ENS de Lyon, CNRS, INRAE, UCBL, Lyon, France.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Feb 10; Vol. 379 (6632), pp. 534-535. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Flowers*/growth & development
Flowers*/metabolism
Pigmentation*/genetics
RNA, Small Interfering*/genetics
RNA, Small Interfering*/metabolism
Mimulus*/genetics
Mimulus*/growth & development

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Skocz do pozycji: 5.

Tytuł:: Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-β reveals anticancer effect in breast cancer.
Autorzy:: Şalva E; Department of Pharmaceutical Biotechnology, İnönü University, Faculty of Pharmacy, Malatya, Turkey.
Özbaş S; Department of Pharmaceutical Biotechnology, Marmara University, Faculty of Pharmacy, İstanbul, Turkey.
Alan S; Department of Medical Pathology, İnönü University, Faculty of Medicine, Malatya, Turkey.
Özkan N; Department of Pathology, Marmara University, Vocational Health School, İstanbul, Turkey.
Ekentok-Atıcı C; Department of Pharmaceutical Biotechnology, Marmara University, Faculty of Pharmacy, İstanbul, Turkey.
Kabasakal L; Department of Pharmacology, Marmara University, Faculty of Pharmacy, İstanbul, Turkey.
Akbuğa J; Department of Pharmaceutical Technology, Medipol University, Faculty of Pharmacy, İstanbul, Turkey.; Pokaż więcej
Źródło:: The journal of gene medicine [J Gene Med] 2023 Feb; Vol. 25 (2), pp. e3465. Date of Electronic Publication: 2022 Dec 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Chitosan*/therapeutic use
RNA, Small Interfering*/genetics
RNA, Small Interfering*/therapeutic use
Female ; Humans ; Nanostructures/therapeutic use ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; RNA Interference

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Skocz do pozycji: 6.

Tytuł:: siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
Autorzy:: Chernikov IV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Staroseletz YY; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Tatarnikova IS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Savin IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Markov AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Logashenko EB; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Chernolovskaya EL; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Zenkova MA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Vlassov VV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 13; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 13.
Typ publikacji:: Journal Article
MeSH Terms:: Acute Lung Injury*/genetics
Acute Lung Injury*/metabolism
RNA, Small Interfering*/genetics
RNA, Small Interfering*/pharmacology
Animals ; Humans ; Mice ; Inflammation/genetics ; Inflammation/metabolism ; Lipopolysaccharides/pharmacology ; Lung/drug effects ; Lung/metabolism ; Mice, Inbred C57BL ; Phenotype ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-1/metabolism

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Skocz do pozycji: 7.

Tytuł:: Blood pressure-independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes.
Autorzy:: Cruz-López EO; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Ren L; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Pharmacy, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
Uijl E; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Clahsen-van Groningen MC; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.; Institute of Experimental Medicine and Systems Biology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
van Veghel R; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Garrelds IM; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Domenig O; Attoquant Diagnostics, Vienna, Austria.
Poglitsch M; Attoquant Diagnostics, Vienna, Austria.
Zlatev I; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Rooney T; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Kasper A; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Nioi P; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Foster D; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Danser AHJ; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2023 Jan; Vol. 180 (1), pp. 80-93. Date of Electronic Publication: 2022 Oct 02.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin II*/drug effects
Angiotensin II*/genetics
Diabetes Mellitus, Experimental*/complications
Diabetes Mellitus, Experimental*/drug therapy
Diabetes Mellitus, Experimental*/metabolism
Hypertension*/drug therapy
Kidney Diseases*/drug therapy
Kidney Diseases*/metabolism
Kidney Diseases*/prevention & control
RNA, Small Interfering*/metabolism
RNA, Small Interfering*/pharmacology
RNA, Small Interfering*/therapeutic use
Animals ; Humans ; Rats ; Albuminuria ; Blood Pressure/drug effects ; Blood Pressure/genetics ; Liver/metabolism ; Renin/metabolism ; Renin-Angiotensin System ; Valsartan/pharmacology

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Skocz do pozycji: 8.

Tytuł:: Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways.
Autorzy:: Kandasamy P; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Mori S; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Matsuda S; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Erande N; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Datta D; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Willoughby JLS; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Taneja N; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
O'Shea J; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Bisbe A; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Manoharan RM; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Yucius K; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Nguyen T; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Indrakanti R; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Gupta S; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Gilbert JA; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Racie T; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Chan A; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Liu J; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Hutabarat R; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Nair JK; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Charisse K; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Maier MA; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Rajeev KG; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.
Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States.
Manoharan M; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2023 Feb 23; Vol. 66 (4), pp. 2506-2523. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Asialoglycoprotein Receptor*/metabolism
Galactosamine*
RNA, Small Interfering*/metabolism
RNA-Induced Silencing Complex*/metabolism
Animals ; Mice ; Acetylgalactosamine/chemistry ; Glycoside Hydrolases/metabolism ; Glycosides/metabolism ; Hepatocytes/metabolism ; Ligands

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Skocz do pozycji: 9.

Tytuł:: Development of Novel siRNA Therapeutics: A Review with a Focus on Inclisiran for the Treatment of Hypercholesterolemia.
Autorzy:: Ebenezer O; Department of Chemistry, Faculty of Natural Science, Mangosuthu University of Technology, Umlazi 4031, South Africa.
Comoglio P; Department of Mechanical and Aerospace Engineering (DIMEAS), Politecnico di Torino, 10129 Turin, Italy.
Wong GK; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Tuszynski JA; Department of Mechanical and Aerospace Engineering (DIMEAS), Politecnico di Torino, 10129 Turin, Italy.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Physics, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Anticholesteremic Agents*/therapeutic use
Cardiovascular Diseases*/drug therapy
Hypercholesterolemia*/metabolism
Hypercholesterolemia*/therapy
RNA, Small Interfering*/therapeutic use
Humans ; Antibodies, Monoclonal/therapeutic use ; Cholesterol, LDL ; Proprotein Convertase 9/genetics

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Skocz do pozycji: 10.

Tytuł:: Taxon-specific, phased siRNAs underlie a speciation locus in monkeyflowers.
Autorzy:: Liang M; Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.
Chen W; Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.; Qinghai Provincial Key Laboratory of Crop Molecular Breeding and Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, Qinghai, China.
LaFountain AM; Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.
Liu Y; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, Guangdong 510642, China.
Peng F; Department of Biology, University of Washington, Seattle, WA 98195, USA.; Department of Biology, Haverford College, Haverford, PA 19041, USA.
Xia R; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, Guangdong 510642, China.
Bradshaw HD; Department of Biology, University of Washington, Seattle, WA 98195, USA.
Yuan YW; Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Feb 10; Vol. 379 (6632), pp. 576-582. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Carotenoids*/metabolism
Flowers*/genetics
Flowers*/growth & development
Mimulus*/genetics
Mimulus*/growth & development
Pigmentation*/genetics
RNA, Small Interfering*/genetics
Gene Expression Regulation, Plant*
Gene Expression Regulation, Developmental*
Genetic Loci

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Skocz do pozycji: 11.

Tytuł:: CNS Delivery of Nucleic Acid Therapeutics: Beyond the Blood-Brain Barrier and Towards Specific Cellular Targeting.
Autorzy:: D'Souza A; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA.; Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, 20115, USA.
Nozohouri S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA.
Bleier BS; Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, 20115, USA.
Amiji MM; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA. .; Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, 02115, USA. .; Pokaż więcej
Źródło:: Pharmaceutical research [Pharm Res] 2023 Jan; Vol. 40 (1), pp. 77-105. Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: MicroRNAs*/therapeutic use
Nucleic Acids*/therapeutic use
RNA, Small Interfering*/therapeutic use
Drug Delivery Systems*
Humans ; Blood-Brain Barrier ; Brain ; Oligonucleotides, Antisense/therapeutic use

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Skocz do pozycji: 12.

Tytuł:: Hyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy.
Autorzy:: Chen D; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.
Zhang P; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.
Li M; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.
Li C; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.
Lu X; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.
Sun Y; Shandong International Biotechnology Park Development Co. Ltd, Yantai, P.R. China.
Sun K; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.; Pokaż więcej
Źródło:: Drug delivery [Drug Deliv] 2022 Dec; Vol. 29 (1), pp. 574-587.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Non-Small-Cell Lung/*pathology
Lung Neoplasms/*pathology
Nanoparticles/*chemistry
RNA, Small Interfering/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Chemistry, Pharmaceutical ; Dendrimers/chemistry ; Drug Carriers/chemistry ; Drug Liberation ; Hyaluronic Acid/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nylons/chemistry ; Oxidation-Reduction ; Particle Size ; RNA, Small Interfering/administration & dosage ; RNA, Small Interfering/pharmacokinetics ; Surface Properties

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Skocz do pozycji: 13.

Tytuł:: The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation.
Autorzy:: Hunter EJ; Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, UK.; Stem Cell and Brain Research Institute, Université Lyon 1, INSERM U1208, 18 Avenue Doyen Lépine, 69500, Bron, France.
Hamaia SW; Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, UK.
Kim PS; Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, UK.
Malcor JM; Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, UK.; Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMS3444 BioSciences Gerland-Lyon Sud, UMR5305, CNRS/Université Lyon 1, Lyon, France.
Farndale RW; Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, UK. .; CambCol Laboratories Ltd, 18 Oak Lane, Littleport, Ely, CB6 1QZ, UK. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Dec 14; Vol. 12 (1), pp. 21601. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Human Umbilical Vein Endothelial Cells*/metabolism
Integrin alpha1beta1*/genetics
Integrin alpha1beta1*/metabolism
Integrin alpha2beta1*/genetics
Integrin alpha2beta1*/metabolism
RNA, Small Interfering*/genetics
Humans ; Cell Adhesion/genetics ; Cell Movement/genetics ; Cell Movement/physiology ; Collagen/genetics ; Collagen/metabolism ; Integrins/genetics ; Integrins/metabolism

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Skocz do pozycji: 14.

Tytuł:: Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC.
Autorzy:: Su C; Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, Lanzhou, China.; Department of Pain, Lanzhou University Second Hospital, Lanzhou, China.
Ren X; Department of Pediatric Orthopedics, Lanzhou University Second Hospital, Lanzhou, China.
Yang F; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China.
Li B; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China.
Wu H; Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, Lanzhou, China.
Li H; Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, Lanzhou, China.
Nie F; Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, Lanzhou, China.; Pokaż więcej
Źródło:: Drug delivery [Drug Deliv] 2022 Dec; Vol. 29 (1), pp. 99-110.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing/*genetics
Carcinoma, Non-Small-Cell Lung/*pathology
LIM Domain Proteins/*genetics
Lung Neoplasms/*pathology
Nanoparticles/*chemistry
RNA, Small Interfering/*pharmacology
Ultrasonic Therapy/*methods
Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival ; Chemistry, Pharmaceutical ; Drug Carriers/chemistry ; Drug Resistance, Neoplasm ; Humans ; Microbubbles ; Particle Size ; RNA, Small Interfering/administration & dosage ; Surface Properties ; Transfection/methods

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Skocz do pozycji: 15.

Tytuł:: Utilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA.
Autorzy:: Guo L; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Shi D; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Shang M; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Sun X; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Meng D; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Liu X; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Zhou X; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Li J; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.; Pokaż więcej
Źródło:: Drug delivery [Drug Deliv] 2022 Dec; Vol. 29 (1), pp. 316-327.
Typ publikacji:: Journal Article
MeSH Terms:: Aptamers, Nucleotide/*pharmacology
Cationic Amino Acid Transporter 1/*pharmacology
Chitosan/*analogs & derivatives
Nanoparticle Drug Delivery System/*chemistry
RNA, Small Interfering/*pharmacology
Ultrasonography, Interventional/*methods
Aptamers, Nucleotide/administration & dosage ; Bacillus Phages/drug effects ; Cationic Amino Acid Transporter 1/administration & dosage ; Cell Line, Tumor ; Cell Movement/drug effects ; Chemistry, Pharmaceutical ; Chitosan/chemistry ; Drug Carriers/chemistry ; Drug Liberation ; Humans ; Particle Size ; Prostate-Specific Antigen/drug effects ; RNA, Small Interfering/administration & dosage ; Surface Properties

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: IGT mediated Nanog siRNA delivery in prostate cancer cells improves chemosensitization of Epirubicin in vitro.
Autorzy:: Gupta S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India.
Das U; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India.
Sinha S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Nov 15; Vol. 76, pp. 129017. Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Epirubicin*/pharmacology
Nanog Homeobox Protein*/genetics
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/genetics
RNA, Small Interfering*/administration & dosage
Drug Resistance, Neoplasm*/genetics
Organic Cation Transport Proteins*
Humans ; Male ; Cell Line, Tumor ; Guanidine/metabolism ; Morpholinos ; Peptides/administration & dosage

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 17.

Tytuł:: Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB.
Autorzy:: Yuen MF; Department of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address: .
Locarnini S; Victorian Infectious Diseases Reference Laboratory, Victoria, Australia.
Lim TH; Department of Gastroenterology, Middlemore Hospital, Auckland, New Zealand.
Strasser SI; AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.
Sievert W; Department of Gastroenterology, Monash Health and Monash University, Melbourne, Australia.
Cheng W; Department of Gastroenterology and Hepatology, Royal Perth Hospital, Perth, Australia; Linear Clinical Research, Perth, Australia.
Thompson AJ; Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Australia.
Given BD; Arrowhead Pharmaceuticals, Pasadena, CA, USA.
Schluep T; Arrowhead Pharmaceuticals, Pasadena, CA, USA.
Hamilton J; Arrowhead Pharmaceuticals, Pasadena, CA, USA.
Biermer M; Janssen Pharmaceuticals NV, Beerse, Belgium.
Kalmeijer R; Janssen Research & Development, Titusville, NJ, USA.
Beumont M; Janssen Research & Development, Titusville, NJ, USA.
Lenz O; Janssen Pharmaceuticals NV, Beerse, Belgium.
De Ridder F; Janssen Pharmaceuticals NV, Beerse, Belgium.
Cloherty G; Abbott Diagnostics, Abbott Park, IL, USA.
Ka-Ho Wong D; Department of Medicine, The University of Hong Kong, Hong Kong, China.
Schwabe C; Auckland Clinical Studies, Auckland, New Zealand.
Jackson K; Victorian Infectious Diseases Reference Laboratory, Victoria, Australia.
Lai CL; Department of Medicine, The University of Hong Kong, Hong Kong, China.
Gish RG; Hepatitis B Foundation, Doylestown, PA, USA.
Gane E; Auckland Clinical Studies, Auckland, New Zealand.; Pokaż więcej
Źródło:: Journal of hepatology [J Hepatol] 2022 Nov; Vol. 77 (5), pp. 1287-1298. Date of Electronic Publication: 2022 Jul 20.
Typ publikacji:: Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hepatitis B, Chronic*/drug therapy
RNA, Small Interfering*/therapeutic use
Humans ; Antiviral Agents/therapeutic use ; Hepatitis B e Antigens ; Hepatitis B Surface Antigens ; Hepatitis B virus/genetics ; Organic Chemicals ; Treatment Outcome ; Drug Therapy, Combination/adverse effects

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 18.

Tytuł:: Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production.
Autorzy:: Wu GR; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Zhou M; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Wang Y; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Zhou Q; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Zhang L; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
He L; Department of Clinical Laboratory, Shanghai East Hospital; School of Medicine, Tongji University, Shanghai, China.
Zhang S; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Yu Q; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Xu Y; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Zhao J; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Xiong W; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.; Department of Respiratory and Critical Care Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Wang CY; Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.; Pokaż więcej
Źródło:: Frontiers in immunology [Front Immunol] 2022 Aug 25; Vol. 13, pp. 930103. Date of Electronic Publication: 2022 Aug 25 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Asthma*/chemically induced
Asthma*/genetics
Asthma*/metabolism
Asthma*/prevention & control
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Liposomes*/administration & dosage
Liposomes*/therapeutic use
Macrophages*/metabolism
RNA, Small Interfering*/administration & dosage
RNA, Small Interfering*/therapeutic use
Animals ; Humans ; Inflammation/chemically induced ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/prevention & control ; Mice ; Mice, Knockout ; Ovalbumin/adverse effects

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na półce

Szczegóły

Skocz do pozycji: 19.

Tytuł:: Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5' to 3' Exoribonucleases.
Autorzy:: Balaratnam S; Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.; Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.
Hoque ME; Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
West N; Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Basu S; Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.; Pokaż więcej
Źródło:: ACS chemical biology [ACS Chem Biol] 2022 Jul 15; Vol. 17 (7), pp. 1723-1732. Date of Electronic Publication: 2022 Jun 10.
Typ publikacji:: Journal Article
MeSH Terms:: Exoribonucleases*/metabolism
RNA Stability*
RNA, Small Interfering*/genetics
RNA, Small Interfering*/metabolism
Argonaute Proteins/metabolism ; Humans

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 20.

Tytuł:: Functionalized Macrophage Exosomes with Panobinostat and PPM1D-siRNA for Diffuse Intrinsic Pontine Gliomas Therapy.
Autorzy:: Shan S; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering & School of Engineering Medicine & Shenzhen Institute of Beihang University, Beihang University, Beijing, 100083, P. R. China.; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Chen J; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering & School of Engineering Medicine & Shenzhen Institute of Beihang University, Beihang University, Beijing, 100083, P. R. China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Sun Y; Pediatric Epilepsy Center, Peking University First Hospital, No.1 Xi'an Men Street, Xicheng District, Beijing, 100034, P. R. China.
Wang Y; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Xia B; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Tan H; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Pan C; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.
Gu G; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.
Zhong J; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Qing G; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Zhang Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Wang J; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Wang Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Wang Y; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.
Zuo P; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.
Xu C; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.
Li F; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
Guo W; Department of Minimally Invasive Interventional Radiology, College of Biomedical Engineering & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, P. R. China.
Xu L; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering & School of Engineering Medicine & Shenzhen Institute of Beihang University, Beihang University, Beijing, 100083, P. R. China.
Chen M; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, P. R. China.
Fan Y; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering & School of Engineering Medicine & Shenzhen Institute of Beihang University, Beihang University, Beijing, 100083, P. R. China.
Zhang L; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering & School of Engineering Medicine & Shenzhen Institute of Beihang University, Beihang University, Beijing, 100083, P. R. China.; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, P. R. China.; China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100070, P. R. China.
Liang XJ; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.; Pokaż więcej
Źródło:: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Jul; Vol. 9 (21), pp. e2200353. Date of Electronic Publication: 2022 May 18.
Typ publikacji:: Journal Article
MeSH Terms:: Diffuse Intrinsic Pontine Glioma*/drug therapy
Diffuse Intrinsic Pontine Glioma*/genetics
Exosomes*/chemistry
Exosomes*/genetics
Glioma*/drug therapy
Glioma*/genetics
Protein Phosphatase 2C*/genetics
Protein Phosphatase 2C*/therapeutic use
RNA, Small Interfering*/genetics
RNA, Small Interfering*/therapeutic use
Animals ; Astrocytoma/drug therapy ; Astrocytoma/genetics ; Brain Stem Neoplasms/drug therapy ; Brain Stem Neoplasms/genetics ; Humans ; Macrophages/chemistry ; Macrophages/metabolism ; Mice ; Panobinostat/therapeutic use

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