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Wyszukujesz frazę ""RNA, Small Interfering"" wg kryterium: Temat


Tytuł :
Structural basis for piRNA targeting.
Autorzy :
Anzelon TA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Chowdhury S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Hughes SM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Xiao Y; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Lander GC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
MacRae IJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. .
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Źródło :
Nature [Nature] 2021 Sep; Vol. 597 (7875), pp. 285-289. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Conformation*
Porifera*/genetics
Porifera*/metabolism
Porifera*/ultrastructure
RNA, Small Interfering/*chemistry
RNA, Small Interfering/*genetics
Animals ; Argonaute Proteins/chemistry ; Argonaute Proteins/metabolism ; Argonaute Proteins/ultrastructure ; Cryoelectron Microscopy ; Models, Molecular ; RNA, Small Interfering/metabolism ; RNA, Small Interfering/ultrastructure ; Substrate Specificity
Czasopismo naukowe
Tytuł :
siRNA: Mechanism of action, challenges, and therapeutic approaches.
Autorzy :
Alshaer W; Cell Therapy Center, The University of Jordan, Amman, 11942, Jordan. Electronic address: .
Zureigat H; Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan.
Al Karaki A; Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan.
Al-Kadash A; Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan.
Gharaibeh L; Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan.
Hatmal MM; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa 13133, Jordan.
Aljabali AAA; Faculty of Pharmacy, Department of Pharmaceutical Sciences, Yarmouk University, Irbid, 21163, Jordan.
Awidi A; Cell Therapy Center, The University of Jordan, Amman, 11942, Jordan; Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan; Department of Hematology and Oncology, Jordan University Hospital, The University of Jordan, Amman, 11942, Jordan. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Aug 15; Vol. 905, pp. 174178. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
RNA, Small Interfering/*pharmacology
RNA, Small Interfering/*therapeutic use
Animals ; Clinical Trials as Topic ; Drug Delivery Systems ; Gene Silencing ; Gene Targeting ; Humans ; RNA Interference ; RNA, Small Interfering/chemistry
Czasopismo naukowe
Tytuł :
Estimating the annual economic burden for the management of patients with transthyretin amyloid polyneuropathy in Spain.
Autorzy :
Galan L; Neurology, Hospital Clínico San Carlos, Madrid, Spain.
Gonzalez-Moreno J; Internal Medicine Services, Hospital Universitario Son Llàtzer, Palma De Mallorca, Spain.
Martínez-Sesmero JM; Pharmacy Services, Hospital Clínico San Carlos, Madrid, Spain.
Muñoz-Beamud F; Internal Medicine Services, Hospital Universitario Juan Ramón Jiménez, Huelva, Spain.
Santos-Rubio MD; Pharmacy Services, Hospital Juan Ramón Jimenez, Huelva, Spain.
Tran D; Value & Evidence, EVERSANA Life Science Services, Burlington, Canada.
Lebeau P; Value & Evidence, EVERSANA Life Science Services, Burlington, Canada.
Stewart M; Patient & Health Impact, Pfizer Inc, Groton, CT, USA.
Mallaina P; ATTR Amyloidosis/Rare Cardiology, Pfizer S.L.U, Madrid, Spain.
Tarilonte P; Rare Disease Medical Department, Pfizer S.L.U, Alcobendas, Madrid, Spain.
Peral C; Health Economics and Outcomes Research Department, Pfizer S.L.U, Alcobendas, Madrid, Spain.
Rozenbaum MH; Patient & Health Impact, Pfizer Inc, Capelle Aan Den IJssel, The Netherlands.
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Źródło :
Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2021 Oct; Vol. 21 (5), pp. 967-973. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Cost of Illness*
Amyloid Neuropathies, Familial/*therapy
Benzoxazoles/*administration & dosage
Oligonucleotides/*administration & dosage
RNA, Small Interfering/*administration & dosage
Amyloid Neuropathies, Familial/economics ; Benzoxazoles/economics ; Drug Costs/statistics & numerical data ; Health Care Costs/statistics & numerical data ; Hospitalization/economics ; Humans ; Oligonucleotides/economics ; RNA, Small Interfering/economics ; Spain
SCR Disease Name :
Amyloidosis, Hereditary, Transthyretin-Related
Czasopismo naukowe
Tytuł :
Identification of inflammation related lncRNAs and Gm33647 as a potential regulator in septic acute lung injury.
Autorzy :
Zou L; Department of Critical Care Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Yu Q; Department of Critical Care Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Zhang L; Department of Critical Care Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Yuan X; Department of Critical Care Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Fang F; Department of Critical Care Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Xu F; Department of Critical Care Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Oct 01; Vol. 282, pp. 119814. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Lung Injury/*immunology
RNA, Long Noncoding/*immunology
RNA, Small Interfering/*immunology
Sepsis/*immunology
Acute Lung Injury/genetics ; Acute Lung Injury/pathology ; Animals ; Cytokines/genetics ; Cytokines/immunology ; Male ; Mice ; RNA, Long Noncoding/genetics ; RNA, Small Interfering/genetics ; Sepsis/genetics ; Sepsis/pathology
Czasopismo naukowe
Tytuł :
Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics.
Autorzy :
Dammes N; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel.; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel.
Goldsmith M; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel.; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel.
Ramishetti S; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel.; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel.
Dearling JLJ; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Veiga N; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel.; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel.
Packard AB; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Peer D; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. .; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel. .; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel. .; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel. .
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Źródło :
Nature nanotechnology [Nat Nanotechnol] 2021 Sep; Vol. 16 (9), pp. 1030-1038. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Colitis/*therapy
Nanoparticles/*chemistry
RNA, Small Interfering/*pharmacology
Animals ; Colitis/genetics ; Gene Expression Regulation/drug effects ; Humans ; Integrin alpha4/chemistry ; Integrin alpha4/genetics ; Integrin beta Chains/chemistry ; Integrin beta Chains/genetics ; Lipids/chemistry ; Lipids/pharmacology ; Liver/drug effects ; Mice ; Nanoparticles/therapeutic use ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2.
Autorzy :
Shawan MMAK; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh. Electronic address: .
Sharma AR; Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-Do 24252, Republic of Korea. Electronic address: .
Bhattacharya M; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore 756020, Odisha, India.
Mallik B; Department of Applied Science, Galgotias College of Engineering and Technology, Knowledge Park-II, Greater Noida, Uttar Pradesh 201306, India.
Akhter F; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; Government Unani and Ayurvedic Medical College Hospital, Mirpur-13, Dhaka 1221, Bangladesh.
Shakil MS; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; Department of Pharmacology & Toxicology, University of Otago, Dunedin, New Zealand.
Hossain MM; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Banik S; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Lee SS; Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-Do 24252, Republic of Korea. Electronic address: .
Hasan MA; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh. Electronic address: .
Chakraborty C; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Jagannathpur, Kolkata, West Bengal 700126, India. Electronic address: .
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Źródło :
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2021 Sep; Vol. 93, pp. 104951. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus RNA-Dependent RNA Polymerase/*genetics
RNA, Small Interfering/*genetics
SARS-CoV-2/*genetics
Argonaute Proteins/chemistry ; Argonaute Proteins/genetics ; Argonaute Proteins/metabolism ; Base Composition ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Gene Silencing ; Genome, Human ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/chemistry ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Variant PNLDC1 , Defective piRNA Processing, and Azoospermia.
Autorzy :
Nagirnaja L; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Mørup N; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Nielsen JE; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Stakaitis R; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Golubickaite I; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Oud MS; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Winge SB; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Carvalho F; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Aston KI; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Khani F; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
van der Heijden GW; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Marques CJ; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Skakkebaek NE; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Rajpert-De Meyts E; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Schlegel PN; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Jørgensen N; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Veltman JA; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Lopes AM; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Conrad DF; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
Almstrup K; From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).
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Źródło :
The New England journal of medicine [N Engl J Med] 2021 Aug 19; Vol. 385 (8), pp. 707-719. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Azoospermia/*genetics
Exoribonucleases/*genetics
Infertility, Male/*genetics
Meiosis/*physiology
RNA, Small Interfering/*metabolism
Testis/*pathology
Adult ; Azoospermia/physiopathology ; Biopsy ; Gene Expression ; Humans ; Male ; Phenotype ; Polymerase Chain Reaction ; RNA, Small Interfering/ultrastructure ; Sequence Analysis, RNA ; Testis/metabolism ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Effects of Angiotensin II type I receptor shRNA on blood pressure and left ventricular remodeling in spontaneously hypertensive rats.
Autorzy :
Zhang J; Department of Cardiology, Tian Jin Chest Hospital, No. 261 of Taierzhuangnan Road, Jinnan District, Tianjin 300222, P.R. China.
Zhang Y; Department of Cardiology, Tian Jin Chest Hospital, No. 261 of Taierzhuangnan Road, Jinnan District, Tianjin 300222, P.R. China.
Xiao C; Department of Cardiology, Second Hospital of Shan Xi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan 030001, P.R. China.
Liu Y; Department of Cardiology, Tian Jin Chest Hospital, No. 261 of Taierzhuangnan Road, Jinnan District, Tianjin 300222, P.R. China.
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Źródło :
Experimental animals [Exp Anim] 2021 Aug 06; Vol. 70 (3), pp. 293-301. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Pressure/*genetics
RNA, Small Interfering/*genetics
Receptor, Angiotensin, Type 1/*genetics
Ventricular Remodeling/*genetics
Animals ; Male ; RNA, Small Interfering/metabolism ; Random Allocation ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptor, Angiotensin, Type 1/metabolism
Czasopismo naukowe
Tytuł :
Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH.
Autorzy :
Tripathi DM; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Rohilla S; School of Biotechnology, Gautam Buddha University, Greater Noida 201312, India.
Kaur I; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Siddiqui H; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Rawal P; School of Biotechnology, Gautam Buddha University, Greater Noida 201312, India.
Juneja P; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Kumar V; Stem Cell Biology Laboratory, National Institute of Immunology, New Delhi 110067, India.
Kumari A; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Naidu VGM; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Guwahati 781122, India.
Ramakrishna S; Department of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore.
Banerjee S; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Guwahati 781122, India.
Puria R; School of Biotechnology, Gautam Buddha University, Greater Noida 201312, India.
Sarin SK; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Kaur S; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 06; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Interference*
Core Binding Factor Alpha 2 Subunit/*genetics
Inflammation/*genetics
Non-alcoholic Fatty Liver Disease/*genetics
RNA, Small Interfering/*genetics
Animals ; Disease Models, Animal ; Endothelial Cells/metabolism ; Inflammation/therapy ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/therapy ; RNA, Small Interfering/therapeutic use ; RNAi Therapeutics
Czasopismo naukowe
Tytuł :
A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs.
Autorzy :
Gong X; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China.
Wang H; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, P. R. China.
Li R; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China.
Tan K; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China.
Wei J; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China.
Wang J; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China.
Hong C; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China.
Shang J; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China.
Liu X; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China. .
Liu J; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, P. R. China.
Wang F; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 25; Vol. 12 (1), pp. 3953. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Precision Medicine*
Hypoxia/*genetics
RNA, Small Interfering/*genetics
RNA, Small Interfering/*therapeutic use
Animals ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Drug Carriers/therapeutic use ; Extracellular Vesicles/chemistry ; Extracellular Vesicles/transplantation ; Gene Silencing ; Humans ; Mice ; MicroRNAs/genetics ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Prodrugs/chemistry ; Prodrugs/pharmacokinetics ; Prodrugs/therapeutic use ; RNA Interference ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/pharmacokinetics
Czasopismo naukowe
Tytuł :
Antisense drug discovery and development technology considered in a pharmacological context.
Autorzy :
Crooke ST; Ionis Pharmaceuticals, Inc., Carlsbad, CA, USA. Electronic address: .
Liang XH; Ionis Pharmaceuticals, Inc., Carlsbad, CA, USA. Electronic address: .
Crooke RM; Ionis Pharmaceuticals, Inc., Carlsbad, CA, USA. Electronic address: .
Baker BF; Ionis Pharmaceuticals, Inc., Carlsbad, CA, USA. Electronic address: .
Geary RS; Ionis Pharmaceuticals, Inc., Carlsbad, CA, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jul; Vol. 189, pp. 114196. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Development/*methods
Drug Discovery/*methods
Oligonucleotides, Antisense/*chemistry
Oligonucleotides, Antisense/*metabolism
RNA, Small Interfering/*chemistry
RNA, Small Interfering/*metabolism
Animals ; Argonaute Proteins/administration & dosage ; Argonaute Proteins/chemistry ; Argonaute Proteins/metabolism ; Drug Administration Routes ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Oligonucleotides, Antisense/administration & dosage ; RNA, Small Interfering/administration & dosage
Czasopismo naukowe
Tytuł :
The growth of siRNA-based therapeutics: Updated clinical studies.
Autorzy :
Zhang MM; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Bahal R; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Rasmussen TP; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Manautou JE; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Zhong XB; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jul; Vol. 189, pp. 114432. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Clinical Trials as Topic/*methods
Drug Development/*methods
Genetic Therapy/*methods
RNA, Small Interfering/*administration & dosage
RNA, Small Interfering/*genetics
Animals ; Gene Transfer Techniques ; Humans ; Hypercholesterolemia/drug therapy ; Hypercholesterolemia/genetics ; Hypercholesterolemia/metabolism ; Nervous System Diseases/drug therapy ; Nervous System Diseases/genetics ; Nervous System Diseases/metabolism ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
Nucleic acids therapeutics using PolyPurine Reverse Hoogsteen hairpins.
Autorzy :
Noé V; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, & IN2UB, University of Barcelona, 08028 Barcelona, Spain.
Aubets E; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, & IN2UB, University of Barcelona, 08028 Barcelona, Spain.
Félix AJ; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, & IN2UB, University of Barcelona, 08028 Barcelona, Spain.
Ciudad CJ; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, & IN2UB, University of Barcelona, 08028 Barcelona, Spain. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jul; Vol. 189, pp. 114371. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Silencing/*drug effects
Gene Targeting/*methods
Inverted Repeat Sequences/*drug effects
Nucleic Acids/*metabolism
RNA, Small Interfering/*metabolism
Animals ; Gene Silencing/physiology ; Humans ; Immunotherapy/methods ; Inverted Repeat Sequences/physiology ; Nucleic Acids/administration & dosage ; Nucleic Acids/genetics ; RNA, Small Interfering/administration & dosage ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Improved Antiviral Activity of Classical Swine Fever Virus-Targeted siRNA by Tetrahedral Framework Nucleic Acid-Enhanced Delivery.
Autorzy :
Dong H; Clinical Medical College, Jilin Ginseng Academy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Song G; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.; Shanghai Institute of Liver Diseases, Shanghai 200001, China.
Ma D; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.; Shanghai Institute of Liver Diseases, Shanghai 200001, China.
Wang T; College of Animal Science, School of Pharmacy, Jilin University, Changchun 130012, China.
Jing S; College of Animal Science, School of Pharmacy, Jilin University, Changchun 130012, China.
Yang H; Clinical Medical College, Jilin Ginseng Academy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Tao Y; Clinical Medical College, Jilin Ginseng Academy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Tang Y; Clinical Medical College, Jilin Ginseng Academy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Shi Y; College of Animal Science, School of Pharmacy, Jilin University, Changchun 130012, China.
Dai Z; Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Zhu JM; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.; Shanghai Institute of Liver Diseases, Shanghai 200001, China.
Liu T; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.; Shanghai Institute of Liver Diseases, Shanghai 200001, China.
Wang B; Clinical Medical College, Jilin Ginseng Academy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Leng X; Clinical Medical College, Jilin Ginseng Academy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Shen X; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.; Shanghai Institute of Liver Diseases, Shanghai 200001, China.
Zhu C; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.; Shanghai Institute of Liver Diseases, Shanghai 200001, China.
Zhao Y; Clinical Medical College, Jilin Ginseng Academy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jun 30; Vol. 13 (25), pp. 29416-29423. Date of Electronic Publication: 2021 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/chemistry
Antiviral Agents*/metabolism
Antiviral Agents*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/metabolism
RNA, Small Interfering*/chemistry
RNA, Small Interfering*/metabolism
RNA, Small Interfering*/pharmacology
Classical Swine Fever Virus/*drug effects
Nanostructures/*chemistry
Animals ; Cell Line ; Nucleic Acids/chemistry ; Nucleic Acids/metabolism ; Swine ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA.
Autorzy :
Mezghrani B; IBMM, Univ. Montpellier, CNRS, ENSCM; Avenue Charles Flahault, CEDEX 05, 34093 Montpellier, France.; ICGM, Univ Montpellier-CNRS-ENSCM, 34090 Montpellier, France.
Ali LMA; IBMM, Univ. Montpellier, CNRS, ENSCM; Avenue Charles Flahault, CEDEX 05, 34093 Montpellier, France.; Department of Biochemistry, Medical Research Institute, University of Alexandria, Alexandria 21561, Egypt.
Richeter S; ICGM, Univ Montpellier-CNRS-ENSCM, 34090 Montpellier, France.
Durand JO; ICGM, Univ Montpellier-CNRS-ENSCM, 34090 Montpellier, France.
Hesemann P; ICGM, Univ Montpellier-CNRS-ENSCM, 34090 Montpellier, France.
Bettache N; IBMM, Univ. Montpellier, CNRS, ENSCM; Avenue Charles Flahault, CEDEX 05, 34093 Montpellier, France.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jun 30; Vol. 13 (25), pp. 29325-29339. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Photochemotherapy*
Nanoparticles/*chemistry
Photosensitizing Agents/*chemistry
RNA, Small Interfering/*chemistry
Silicon Dioxide/*chemistry
Cells, Cultured ; Gene Silencing ; Human Umbilical Vein Endothelial Cells ; Humans ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
siRNA enrichment in Argonaute 2-depleted Blattella germanica.
Autorzy :
Montañés JC; Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain.
Rojano C; Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain.
Ylla G; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. Electronic address: .
Piulachs MD; Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain. Electronic address: .
Maestro JL; Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2021 Jun-Jul; Vol. 1864 (6-7), pp. 194704. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Animals, Genetically Modified*/genetics
Animals, Genetically Modified*/metabolism
Blattellidae*/genetics
Blattellidae*/metabolism
Gene Silencing*
RNA, Small Interfering*/genetics
RNA, Small Interfering*/metabolism
Argonaute Proteins/*deficiency
Insect Proteins/*deficiency
Animals ; Argonaute Proteins/genetics ; Insect Proteins/genetics
Czasopismo naukowe
Tytuł :
Sustained and targeted delivery of siRNA/DP7-C nanoparticles from injectable thermosensitive hydrogel for hepatocellular carcinoma therapy.
Autorzy :
Zhao B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Zhou B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Shi K; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Zhang R; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Dong C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Xie D; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Tang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Tian Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Qian Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Yang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2481-2492. Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylgalactosamine/*chemistry
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
NIMA-Interacting Peptidylprolyl Isomerase/*antagonists & inhibitors
RNA, Small Interfering/*administration & dosage
Animals ; Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Delayed-Action Preparations ; Drug Compounding ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hydrogels/chemistry ; Injections, Subcutaneous ; Liver Neoplasms/genetics ; Mice ; NIMA-Interacting Peptidylprolyl Isomerase/genetics ; Pore Forming Cytotoxic Proteins/chemistry ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/pharmacology ; Thermodynamics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs.
Autorzy :
Xue C; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Hu S; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Gao ZH; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medicine Genetics, School of Laboratory Medicine and Life Sciences, Institute of Functional Nucleic Acids and Personalized Cancer Theranostics, Wenzhou Medical University, Wenzhou, 325035, China.
Wang L; Hunan Provincial Key Laboratory of Phytohormones and Growth Development, College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410128, China.
Luo MX; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Yu X; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Li BF; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Shen Z; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medicine Genetics, School of Laboratory Medicine and Life Sciences, Institute of Functional Nucleic Acids and Personalized Cancer Theranostics, Wenzhou Medical University, Wenzhou, 325035, China.
Wu ZS; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China. .
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Źródło :
Nature communications [Nat Commun] 2021 May 18; Vol. 12 (1), pp. 2928. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Transfer Techniques*
DNA/*chemistry
Gold/*chemistry
Metal Nanoparticles/*chemistry
Neoplasms/*genetics
RNA, Small Interfering/*genetics
A549 Cells ; Animals ; DNA/genetics ; Gene Silencing ; HeLa Cells ; Humans ; MCF-7 Cells ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms/metabolism ; Neoplasms/therapy ; RNA, Small Interfering/administration & dosage ; RNA, Small Interfering/pharmacokinetics ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
RNase κ promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors.
Autorzy :
Shigematsu M; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Kawamura T; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Morichika K; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Izumi N; Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Kiuchi T; Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Honda S; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Pliatsika V; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Matsubara R; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Rigoutsos I; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Katsuma S; Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Tomari Y; Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Kirino Y; Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 23; Vol. 12 (1), pp. 4498. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoribonucleases/*genetics
Gene Expression Profiling/*methods
Insect Proteins/*genetics
RNA/*genetics
RNA, Small Interfering/*genetics
Animals ; Base Sequence ; Bombyx ; Cell Line ; Endoribonucleases/metabolism ; Female ; Insect Proteins/metabolism ; Male ; Mice, Inbred C57BL ; Mutation ; Phosphatidic Acids/chemistry ; RNA/chemistry ; RNA/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; RNA-Seq/methods ; Testis/metabolism
Czasopismo naukowe
Tytuł :
Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.
Autorzy :
Dong SXM; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Vizeacoumar FS; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Bhanumathy KK; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Alli N; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Gonzalez-Lopez C; Cancer Research, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, SK, Canada.
Gajanayaka N; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Caballero R; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Ali H; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Freywald A; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Cassol E; Department of Health Sciences, Carleton University, Ottawa, ON, Canada.
Angel JB; Department of Medicine, the Ottawa Health Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Vizeacoumar FJ; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. .; Cancer Research, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, SK, Canada. .
Kumar A; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. .; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. .; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. .
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2021 Jul 07; Vol. 21 (1), pp. 655. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Green Fluorescent Proteins*
HIV Infections*/genetics
HIV Infections*/virology
Macrophages*
RNA, Small Interfering*
Apoptosis/*genetics
CD4-Positive T-Lymphocytes/virology ; Genome-Wide Association Study ; HIV-1/physiology ; Humans ; T-Lymphocytes
Czasopismo naukowe

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