Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""RNA, Small Interfering"" wg kryterium: Temat


Tytuł :
Codelivery of HIF-1α siRNA and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression.
Autorzy :
Izadi S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Moslehi A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Kheiry H; Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
Karoon Kiani F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ahmadi A; Department of Chemical and Materials Engineering, The University of Alabama in Huntsville, Huntsville, Alabama, 35899, USA.
Masjedi A; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ghani S; Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rafiee B; Department of Biology, Faculty of Basic Science, Payame Noor University, Tehran, Iran.
Karpisheh V; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hajizadeh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Atyabi F; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Assali A; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Mirzazadeh Tekie FS; Department of radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Namdar A; Department of Oncology, Cross Cancer Institute, The University of Alberta, Edmonton, Alberta, Canada.
Ghalamfarsa G; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Sojoodi M; Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, USA. .
Jadidi-Niaragh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. .
Pokaż więcej
Źródło :
Pharmaceutical research [Pharm Res] 2020 Sep 17; Vol. 37 (10), pp. 196. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE
MeSH Terms :
Bridged Bicyclo Compounds, Heterocyclic/*administration & dosage
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
Neoplasms, Experimental/*therapy
Pyridinium Compounds/*administration & dosage
RNA, Small Interfering/*administration & dosage
Animals ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/pharmacokinetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Chitosan/chemistry ; Graphite/chemistry ; Hyaluronic Acid/chemistry ; Mice ; Nanoparticles/chemistry ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Pyridinium Compounds/chemistry ; Pyridinium Compounds/pharmacokinetics ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacokinetics
Czasopismo naukowe
Tytuł :
A universal method for the rapid isolation of all known classes of functional silencing small RNAs.
Autorzy :
Grentzinger T; Department of Biology, Swiss Federal Institute of Technology (ETH), Zürich, 8092, Switzerland.
Oberlin S; Department of Biology, Swiss Federal Institute of Technology (ETH), Zürich, 8092, Switzerland.
Schott G; Department of Biology, Swiss Federal Institute of Technology (ETH), Zürich, 8092, Switzerland.
Handler D; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, 1030, Austria.
Svozil J; Department of Biology, Swiss Federal Institute of Technology (ETH), Zürich, 8092, Switzerland.
Barragan-Borrero V; Department of Biology, Swiss Federal Institute of Technology (ETH), Zürich, 8092, Switzerland.
Humbert A; Institut Jacques Monod, Université de Paris, CNRS, Paris, 75013, France.
Duharcourt S; Institut Jacques Monod, Université de Paris, CNRS, Paris, 75013, France.
Brennecke J; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, 1030, Austria.
Voinnet O; Department of Biology, Swiss Federal Institute of Technology (ETH), Zürich, 8092, Switzerland.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Aug 20; Vol. 48 (14), pp. e79.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res. Subsets: MEDLINE
MeSH Terms :
Argonaute Proteins/*metabolism
Chromatography, Liquid/*methods
RNA, Small Interfering/*isolation & purification
RNA-Induced Silencing Complex/*chemistry
Animals ; Anion Exchange Resins ; Argonaute Proteins/isolation & purification ; Cell Line, Tumor ; Gene Library ; Mice ; Mice, Inbred C57BL ; Polynucleotide 5'-Hydroxyl-Kinase ; RNA, Fungal/isolation & purification ; RNA, Helminth/isolation & purification ; RNA, Neoplasm/isolation & purification ; RNA, Plant/isolation & purification ; RNA, Protozoan/isolation & purification ; RNA, Small Interfering/blood ; RNA, Small Interfering/metabolism ; Sepharose ; Silicon Dioxide ; Ultracentrifugation
Czasopismo naukowe
Tytuł :
Engineering DNA nanostructures for siRNA delivery in plants.
Autorzy :
Zhang H; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA.
Zhang H; California Institute for Quantitative Biosciences (QB3), University of California Berkeley, Berkeley, CA, USA.
Demirer GS; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA.
González-Grandío E; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA.
Fan C; School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Landry MP; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA. .; California Institute for Quantitative Biosciences (QB3), University of California Berkeley, Berkeley, CA, USA. .; Chan-Zuckerberg Biohub, San Francisco, CA, USA. .
Pokaż więcej
Źródło :
Nature protocols [Nat Protoc] 2020 Sep; Vol. 15 (9), pp. 3064-3087. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE
MeSH Terms :
Engineering*
DNA/*chemistry
Drug Carriers/*chemistry
Nanostructures/*chemistry
RNA, Small Interfering/*metabolism
Tobacco/*metabolism
DNA/metabolism ; Drug Carriers/metabolism ; RNA, Small Interfering/genetics ; Tobacco/genetics
Czasopismo naukowe
Tytuł :
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
Autorzy :
Suen KM; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
Braukmann F; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
Butler R; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.
Bensaddek D; Laboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.; Bioscience Core labs, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.
Akay A; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.; School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
Lin CC; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
Milonaitytė D; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
Doshi N; University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Sapetschnig A; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK.
Lamond A; Laboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
Ladbury JE; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
Miska EA; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK. .; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. .; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Aug 25; Vol. 11 (1), pp. 4242. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Gene Silencing*
Argonaute Proteins/*metabolism
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
RNA, Small Interfering/*metabolism
Animals ; Argonaute Proteins/genetics ; Binding Sites ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/genetics ; Cytoplasmic Granules/metabolism ; Germ Cells/metabolism ; Mutation ; Protein Binding ; Proteomics ; RNA Interference ; RNA, Double-Stranded/metabolism ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
NATpare: a pipeline for high-throughput prediction and functional analysis of nat-siRNAs.
Autorzy :
Thody J; School of Computing Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Folkes L; School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Moulton V; School of Computing Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jul 09; Vol. 48 (12), pp. 6481-6490.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res. Subsets: MEDLINE
MeSH Terms :
Software*
RNA, Plant/*genetics
RNA, Small Interfering/*chemistry
Sequence Analysis, RNA/*methods
Arabidopsis ; RNA Interference ; RNA, Plant/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
Phase 3 Multicenter Study of Revusiran in Patients with Hereditary Transthyretin-Mediated (hATTR) Amyloidosis with Cardiomyopathy (ENDEAVOUR).
Autorzy :
Judge DP; Johns Hopkins Hospital, Baltimore, MD, USA.; Medical University of South Carolina, Charleston, SC, USA.
Kristen AV; Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
Grogan M; Mayo Clinic, Rochester, MN, USA.
Maurer MS; Columbia University Medical Center, New York, NY, USA.
Falk RH; Brigham and Women's Hospital, Boston, MA, USA.
Hanna M; Cleveland Clinic, Cleveland, OH, USA.
Gillmore J; National Amyloidosis Centre, Division of Medicine, UCL Medical School Royal Free Hospital Rowland Hill Street, NW3 2PF, London, UK.
Garg P; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Vaishnaw AK; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Harrop J; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Powell C; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Karsten V; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Zhang X; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Sweetser MT; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Vest J; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Hawkins PN; National Amyloidosis Centre, Division of Medicine, UCL Medical School Royal Free Hospital Rowland Hill Street, NW3 2PF, London, UK. .
Pokaż więcej
Źródło :
Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2020 Jun; Vol. 34 (3), pp. 357-370.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE
MeSH Terms :
RNAi Therapeutics*/adverse effects
Amyloid Neuropathies, Familial/*therapy
Cardiomyopathies/*drug therapy
Prealbumin/*genetics
RNA, Small Interfering/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Amyloid Neuropathies, Familial/blood ; Amyloid Neuropathies, Familial/genetics ; Amyloid Neuropathies, Familial/physiopathology ; Canada ; Cardiomyopathies/blood ; Cardiomyopathies/genetics ; Cardiomyopathies/physiopathology ; Cause of Death ; Disease Progression ; Early Termination of Clinical Trials ; Europe ; Exercise Tolerance/drug effects ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Mutation ; Phenotype ; Prealbumin/metabolism ; RNA, Small Interfering/adverse effects ; RNA, Small Interfering/pharmacokinetics ; Recovery of Function ; Time Factors ; Treatment Outcome ; United States
SCR Disease Name :
Amyloidosis, Hereditary, Transthyretin-Related
Czasopismo naukowe
Tytuł :
Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference.
Autorzy :
Habibian M; Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada.
Harikrishna S; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India.
Fakhoury J; Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada.
Barton M; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL, USA.
Ageely EA; Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL, USA.
Cencic R; Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3G 1Y6, Canada.
Fakih HH; Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada.
Katolik A; Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada.
Takahashi M; Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Rossi J; Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Pelletier J; Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3G 1Y6, Canada.
Gagnon KT; Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL, USA.; Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL, USA.
Pradeepkumar PI; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India.
Damha MJ; Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 May 21; Vol. 48 (9), pp. 4643-4657.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res. Subsets: MEDLINE
MeSH Terms :
RNA Interference*
RNA, Small Interfering/*chemistry
Argonaute Proteins/metabolism ; Carbohydrate Conformation ; HeLa Cells ; Humans ; Luciferases, Firefly/genetics ; Molecular Dynamics Simulation ; Nucleic Acid Conformation ; RNA, Small Interfering/chemical synthesis ; RNA, Small Interfering/immunology ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Fine-tune control of targeted RNAi efficacy by plant artificial small RNAs.
Autorzy :
López-Dolz L; Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universitat Politècnica de València, 46022 Valencia, Spain.
Spada M; Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universitat Politècnica de València, 46022 Valencia, Spain.
Daròs JA; Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universitat Politècnica de València, 46022 Valencia, Spain.
Carbonell A; Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universitat Politècnica de València, 46022 Valencia, Spain.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 19; Vol. 48 (11), pp. 6234-6250.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res. Subsets: MEDLINE
MeSH Terms :
Gene Expression Regulation, Plant*
RNA Interference*
Arabidopsis/*genetics
RNA, Small Interfering/*genetics
Base Pairing ; Base Sequence ; Genetic Vectors ; RNA, Small Interfering/metabolism ; Tobacco/genetics ; Tobacco/virology
Czasopismo naukowe
Tytuł :
Generation and validation of structurally defined antibody-siRNA conjugates.
Autorzy :
Nanna AR; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.; Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA.
Kel'in AV; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Theile C; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Pierson JM; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Voo ZX; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Garg A; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Nair JK; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Maier MA; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Fitzgerald K; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Rader C; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 04; Vol. 48 (10), pp. 5281-5293.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
MeSH Terms :
RNA Interference*
Immunoglobulin Variable Region/*chemistry
RNA, Small Interfering/*chemistry
Antibodies/chemistry ; Cell Line, Tumor ; Humans ; RNA, Small Interfering/pharmacokinetics ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitro.
Autorzy :
Li CC; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Wang XJ; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. .
Pokaż więcej
Źródło :
Virology journal [Virol J] 2020 Jun 03; Vol. 17 (1), pp. 71. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol. J. Subsets: MEDLINE
MeSH Terms :
Antiviral Agents/*pharmacology
Homoharringtonine/*pharmacology
Hydroxychloroquine/*pharmacology
Porcine epidemic diarrhea virus/*drug effects
RNA, Small Interfering/*pharmacology
Animals ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Drug Synergism ; Nucleocapsid Proteins/genetics ; Peptides/pharmacology ; RNA, Small Interfering/genetics ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/chemistry ; Vero Cells ; Viral Load/drug effects ; Viral Matrix Proteins/genetics
Czasopismo naukowe
Tytuł :
A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest.
Autorzy :
Liu M; Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Li Y; Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China; Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
Gao S; Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yan S; Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Zhang Q; Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Liu G; Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Ji B; Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. Electronic address: .
Pokaż więcej
Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2020 Jun; Vol. 159 (6), pp. 2431-2444.e7. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Webcast
Journal Info :
Publisher: Mosby Country of Publication: United States NLM ID: 0376343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-685X (Electronic) Linking ISSN: 00225223 NLM ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
RNA Interference*
Circulatory Arrest, Deep Hypothermia Induced/*adverse effects
Cold Shock Proteins and Peptides/*metabolism
Encephalitis/*prevention & control
Hippocampus/*metabolism
Microglia/*metabolism
Neurons/*metabolism
RNA, Small Interfering/*metabolism
RNA-Binding Proteins/*metabolism
Animals ; Cell Death ; Cell Line, Tumor ; Cold Shock Proteins and Peptides/deficiency ; Cold Shock Proteins and Peptides/genetics ; Disease Models, Animal ; Encephalitis/genetics ; Encephalitis/metabolism ; Encephalitis/pathology ; Hippocampus/pathology ; Humans ; Male ; Mice ; Microglia/pathology ; NF-kappa B/metabolism ; Neurons/pathology ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/genetics ; Rats, Sprague-Dawley ; Rats, Transgenic ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Plant 22-nt siRNAs mediate translational repression and stress adaptation.
Autorzy :
Wu H; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.
Li B; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.
Iwakawa HO; Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), Saitama, Japan.
Pan Y; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.; Key Laboratory of Plant Ecology, Northeast Forestry University, Harbin, China.
Tang X; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.; Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Ling-Hu Q; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.
Liu Y; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.
Sheng S; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.
Feng L; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.
Zhang H; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.
Zhang X; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.; Lingnan Guangdong Laboratory of Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Tang Z; Key Laboratory of Plant Ecology, Northeast Forestry University, Harbin, China.
Xia X; Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Zhai J; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China.
Guo H; Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, China. .
Pokaż więcej
Źródło :
Nature [Nature] 2020 May; Vol. 581 (7806), pp. 89-93. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
MeSH Terms :
Gene Expression Regulation, Plant*
Acclimatization/*genetics
Arabidopsis/*genetics
Protein Biosynthesis/*genetics
RNA, Plant/*genetics
RNA, Small Interfering/*genetics
Arabidopsis/growth & development ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Argonaute Proteins/metabolism ; Cell Cycle Proteins ; Gene Silencing ; Mutation ; Nitrate Reductase/genetics ; Plant Diseases/genetics ; RNA Stability ; RNA, Messenger/genetics ; RNA, Small Interfering/biosynthesis ; Ribonuclease III/metabolism
Czasopismo naukowe
Tytuł :
Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs.
Autorzy :
Lü J; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Zhao Q; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Ding X; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Guo Y; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Li Y; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Xu Z; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.; Wenzhou Medical University, Wenzhou City, Zhejiang, China.
Li S; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Wang Z; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Shen L; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Chen HW; Computational Medicine Center, Thomas Jefferson University, 233 South 10th St. Philadelphia PA 19107, U.S.A.
Yu Z; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.; Wenzhou Medical University, Wenzhou City, Zhejiang, China.
Pestell RG; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center, 3805 Old Easton Road, Doylestown, PA 18902, U.S.A.
Pokaż więcej
Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Apr 17; Vol. 134 (7), pp. 791-805.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin. Sci. Subsets: MEDLINE
MeSH Terms :
Breast Neoplasms/*metabolism
Cyclin D1/*metabolism
MicroRNAs/*metabolism
Neoplastic Stem Cells/*metabolism
RNA, Small Interfering/*metabolism
Animals ; Argonaute Proteins/genetics ; Argonaute Proteins/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Cellular Microenvironment ; Cyclin D1/genetics ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MCF-7 Cells ; Mice, Transgenic ; MicroRNAs/genetics ; MicroRNAs/immunology ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/pathology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.
Autorzy :
Ray KK; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Wright RS; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Kallend D; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Koenig W; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Leiter LA; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Raal FJ; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Bisch JA; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Richardson T; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Jaros M; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Wijngaard PLJ; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Kastelein JJP; From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).
Pokaż więcej
Corporate Authors :
ORION-10 and ORION-11 Investigators
Źródło :
The New England journal of medicine [N Engl J Med] 2020 Apr 16; Vol. 382 (16), pp. 1507-1519. Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Anticholesteremic Agents/*therapeutic use
Cholesterol, LDL/*blood
Coronary Artery Disease/*drug therapy
Hypercholesterolemia/*drug therapy
Proprotein Convertase 9/*antagonists & inhibitors
RNA, Small Interfering/*therapeutic use
Aged ; Aged, 80 and over ; Anticholesteremic Agents/adverse effects ; Anticholesteremic Agents/pharmacokinetics ; Cardiovascular Diseases ; Coronary Artery Disease/complications ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypercholesterolemia/blood ; Hypercholesterolemia/complications ; Injections, Subcutaneous/adverse effects ; Liver Function Tests ; Male ; Middle Aged ; RNA, Small Interfering/adverse effects ; RNA, Small Interfering/pharmacokinetics ; Risk Factors
Czasopismo naukowe
Tytuł :
Chronic Microangiopathy Due to DCR-MYC, a Myc-Targeted Short Interfering RNA.
Autorzy :
Miller AJ; Department of Pathology, University of Chicago, Chicago, IL.
Chang A; Department of Pathology, University of Chicago, Chicago, IL.
Cunningham PN; Department of Medicine, University of Chicago, Chicago, IL. Electronic address: .
Pokaż więcej
Źródło :
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2020 Apr; Vol. 75 (4), pp. 513-516. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :
Case Reports
Journal Info :
Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8110075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-6838 (Electronic) Linking ISSN: 02726386 NLM ISO Abbreviation: Am. J. Kidney Dis. Subsets: MEDLINE
MeSH Terms :
Proto-Oncogene Proteins c-myc/*genetics
RNA, Small Interfering/*adverse effects
RNA, Small Interfering/*genetics
Thrombotic Microangiopathies/*chemically induced
Thrombotic Microangiopathies/*genetics
Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Chronic Disease ; Drug Delivery Systems/adverse effects ; Drug Delivery Systems/methods ; Fatal Outcome ; Female ; Gene Targeting/adverse effects ; Gene Targeting/methods ; Humans ; Proto-Oncogene Proteins c-myc/antagonists & inhibitors ; RNA, Small Interfering/administration & dosage ; Thrombotic Microangiopathies/diagnosis
Raport
Tytuł :
siRNA therapeutics: a clinical reality.
Autorzy :
Saw PE; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Song EW; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Zhongshan School of Medicine, Breast Surgery, Guangzhou, 510080, China. .
Pokaż więcej
Źródło :
Science China. Life sciences [Sci China Life Sci] 2020 Apr; Vol. 63 (4), pp. 485-500. Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE
MeSH Terms :
RNA, Small Interfering/*administration & dosage
RNA, Small Interfering/*therapeutic use
Animals ; Biological Transport ; Drug Approval ; Gene Silencing ; Gene Transfer Techniques ; Genetic Therapy ; Humans ; Nanocapsules/chemistry ; Polyneuropathies/genetics ; Polyneuropathies/therapy ; RNA Interference ; RNA, Small Interfering/chemistry ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer.
Autorzy :
Zhang Q; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Zhang H; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Ning T; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Liu D; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Deng T; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Liu R; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Bai M; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Zhu K; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Li J; Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease; Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai 200001, People's Republic of China.
Fan Q; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Ying G; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Ba Y; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, People's Republic of China.
Pokaż więcej
Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Apr 01; Vol. 15, pp. 2323-2335. Date of Electronic Publication: 2020 Apr 01 (Print Publication: 2020).
Typ publikacji :
Journal Article
Journal Info :
Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
MeSH Terms :
Cisplatin/*pharmacology
Drug Delivery Systems/*methods
Drug Resistance, Neoplasm/*genetics
RNA, Small Interfering/*administration & dosage
Stomach Neoplasms/*drug therapy
c-Mer Tyrosine Kinase/*genetics
Animals ; Apoptosis/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Exosomes/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice, Nude ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Stomach Neoplasms/genetics ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Xenograft Model Antitumor Assays ; c-Mer Tyrosine Kinase/metabolism
Czasopismo naukowe
Tytuł :
[Research progress in transdermal delivery for small interfering RNA].
Autorzy :
Chen Y; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, Zhejiang, China.
Xu N; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, Zhejiang, China.
Hu Z; Institute of Life Sciences, Wenzhou University, Wenzhou 325035, Zhejiang, China.
Pokaż więcej
Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2020 Apr 25; Vol. 36 (4), pp. 622-631.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Ke xue chu ban she Country of Publication: China NLM ID: 9426463 Publication Model: Print Cited Medium: Internet ISSN: 1872-2075 (Electronic) Linking ISSN: 10003061 NLM ISO Abbreviation: Sheng Wu Gong Cheng Xue Bao Subsets: MEDLINE
MeSH Terms :
Administration, Cutaneous*
RNA, Small Interfering*/administration & dosage
Skin Diseases*/therapy
Genetic Vectors/administration & dosage ; Humans
Czasopismo naukowe
Tytuł :
p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis.
Autorzy :
Shin HJ; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Park H; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Shin N; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Shin J; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Gwon DH; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Kwon HH; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Pediatrics.
Yin Y; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Hwang JA; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Hong J; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Heo JY; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Biochemistry.; Infection Control Convergence Research Center.
Kim CS; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Physiology Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Joo Y; Department of Orthopedics, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Kim Y; Department of Orthopedics, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Kim J; Division of Rheumatology, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Beom J; Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Republic of Korea.
Kim DW; Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.; Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Pokaż więcej
Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Apr 08; Vol. 15, pp. 2379-2390. Date of Electronic Publication: 2020 Apr 08 (Print Publication: 2020).
Typ publikacji :
Journal Article
Journal Info :
Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
MeSH Terms :
Mitochondria/*pathology
Osteoarthritis/*drug therapy
RNA, Small Interfering/*pharmacology
Src Homology 2 Domain-Containing, Transforming Protein 1/*genetics
Src Homology 2 Domain-Containing, Transforming Protein 1/*metabolism
Animals ; Cartilage, Articular/metabolism ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Iodoacetic Acid/toxicity ; Knee Joint/diagnostic imaging ; Knee Joint/drug effects ; Male ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use ; Osteoarthritis/chemically induced ; Osteoarthritis/pathology ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; RNA, Small Interfering/administration & dosage ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis.
Autorzy :
Li F; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Yuan P; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Rao M; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Jin CH; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.
Tang W; The Animal Core Facility, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Rong YF; Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China.
Hu YP; Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang F; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Wei T; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Yin Q; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Liang T; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Wu L; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Li J; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Li D; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Liu Y; Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lou W; Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China.
Zhao S; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China. .
Liu MF; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China. .; School of Life Science and Technology, Shanghai Tech University, Shanghai, China. .
Pokaż więcej
Źródło :
Nature cell biology [Nat Cell Biol] 2020 Apr; Vol. 22 (4), pp. 425-438. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat. Cell Biol. Subsets: MEDLINE
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adenocarcinoma/*genetics
Argonaute Proteins/*genetics
Carcinoma, Pancreatic Ductal/*genetics
Cell Adhesion Molecules/*genetics
Nuclear Proteins/*genetics
Pancreatic Neoplasms/*genetics
RNA, Small Interfering/*genetics
Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Anaphase ; Anaphase-Promoting Complex-Cyclosome/genetics ; Anaphase-Promoting Complex-Cyclosome/metabolism ; Animals ; Argonaute Proteins/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Adhesion Molecules/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Lymphatic Metastasis ; Male ; Mice ; Mice, Knockout ; Mice, Nude ; Nuclear Proteins/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; RNA, Small Interfering/metabolism ; Signal Transduction ; Spermatogenesis/genetics ; Ubiquitination ; Xenograft Model Antitumor Assays
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies