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Wyszukujesz frazę ""RNA, Transfer, Met"" wg kryterium: Temat


Tytuł :
Synthesis and properties of the anticodon stem-loop of human mitochondrial tRNA G nucleosides at position 37.
Autorzy :
Podskoczyj K; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, Lodz 90-924, Poland. .
Kulik K; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Division of Bioorganic Chemistry, Sienkiewicza 112, Lodz 90-363, Poland.
Wasko J; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, Lodz 90-924, Poland. .
Nawrot B; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Division of Bioorganic Chemistry, Sienkiewicza 112, Lodz 90-363, Poland.
Suzuki T; Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Leszczynska G; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, Lodz 90-924, Poland. .
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Nov 23; Vol. 57 (93), pp. 12540-12543. Date of Electronic Publication: 2021 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Guanosine/*analogs & derivatives
Guanosine/*chemistry
Mitochondria/*metabolism
RNA, Transfer, Met/*genetics
Codon ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Humans ; Hypertension/genetics ; Hypertension/pathology ; Nucleic Acid Conformation ; Optic Atrophy, Hereditary, Leber/genetics ; Optic Atrophy, Hereditary, Leber/pathology ; RNA, Transfer, Met/chemistry
Czasopismo naukowe
Tytuł :
Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA.
Autorzy :
Mukhopadhyay S; Department of Biochemistry and Molecular Biology, Southern Illinois University, Carbondale, Illinois 62901-4413, USA.
Deogharia M; Department of Biochemistry and Molecular Biology, Southern Illinois University, Carbondale, Illinois 62901-4413, USA.
Gupta R; Department of Biochemistry and Molecular Biology, Southern Illinois University, Carbondale, Illinois 62901-4413, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Jan; Vol. 27 (1), pp. 66-79. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Nucleus/*genetics
Cytoplasm/*genetics
Hydro-Lyases/*genetics
Mitochondria/*genetics
Pseudouridine/*metabolism
RNA, Transfer, Ala/*genetics
RNA, Transfer, Met/*genetics
RNA, Transfer, Trp/*genetics
Animals ; Binding Sites ; Cell Compartmentation ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Gene Expression ; HEK293 Cells ; Humans ; Hydro-Lyases/metabolism ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mitochondria/metabolism ; PC-3 Cells ; Protein Binding ; RNA, Transfer, Ala/metabolism ; RNA, Transfer, Met/metabolism ; RNA, Transfer, Trp/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sf9 Cells ; Spodoptera
Czasopismo naukowe
Tytuł :
Identification and characterization of VapBC toxin-antitoxin system in Bosea sp. PAMC 26642 isolated from Arctic lichens.
Autorzy :
Jeon H; Department of Microbiology, Pusan National University, Busan 46241, Republic of Korea.
Choi E; Department of Microbiology, Pusan National University, Busan 46241, Republic of Korea.; Microbiological Resource Research Institute, Pusan National University, Busan 46241, Republic of Korea.
Hwang J; Department of Microbiology, Pusan National University, Busan 46241, Republic of Korea.; Microbiological Resource Research Institute, Pusan National University, Busan 46241, Republic of Korea.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Nov; Vol. 27 (11), pp. 1374-1389. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Bacterial*
Antitoxins/*metabolism
Bacterial Toxins/*metabolism
Bradyrhizobiaceae/*growth & development
Escherichia coli/*growth & development
RNA, Transfer, Met/*metabolism
Toxin-Antitoxin Systems/*genetics
Antitoxins/genetics ; Bacterial Proteins ; Bacterial Toxins/genetics ; Bradyrhizobiaceae/genetics ; Bradyrhizobiaceae/isolation & purification ; Bradyrhizobiaceae/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Lichens/physiology ; Operon ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA.
Autorzy :
Tang DJ; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Du X; Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Shi Q; Endoscopy Center, Zhongshan Hospital of Fudan University, Shanghai, China.
Zhang JL; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.; School of Public Health, Zunyi Medical University, 563000, Zunyi, Guizhou, China.
He YP; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Chen YM; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Ming Z; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Wang D; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Zhong WY; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Liang YW; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Liu JY; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China.
Huang JM; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Zhong YS; Endoscopy Center, Zhongshan Hospital of Fudan University, Shanghai, China.
An SQ; National Biofilms Innovation Centre (NBIC), Biological Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK.
Gu H; Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China. .; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China. .; Endoscopy Center, Zhongshan Hospital of Fudan University, Shanghai, China. .
Tang JL; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Guangxi, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 03; Vol. 11 (1), pp. 2794. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Riboswitch*
RNA, Transfer, Met/*metabolism
S-Adenosylmethionine/*metabolism
Base Sequence ; Genetic Loci ; Models, Biological ; Nucleic Acid Conformation ; Operon/genetics ; Protein Biosynthesis ; RNA, Transfer, Met/chemistry ; RNA, Transfer, Met/genetics
Czasopismo naukowe
Tytuł :
Direct Measurements of Erythromycin's Effect on Protein Synthesis Kinetics in Living Bacterial Cells.
Autorzy :
Seefeldt AC; Department of Cell and Molecular Biology, Uppsala University, Sweden.
Aguirre Rivera J; Department of Cell and Molecular Biology, Uppsala University, Sweden.
Johansson M; Department of Cell and Molecular Biology, Uppsala University, Sweden. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 May 14; Vol. 433 (10), pp. 166942. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Erythromycin/*pharmacology
Escherichia coli/*drug effects
Protein Biosynthesis/*drug effects
Protein Synthesis Inhibitors/*pharmacology
Ribosomes/*drug effects
Amino Acid Sequence ; Anti-Bacterial Agents/metabolism ; Carbocyanines/chemistry ; Codon ; Erythromycin/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fluorescent Dyes/chemistry ; Peptides/chemistry ; Peptides/genetics ; Peptides/metabolism ; Protein Binding ; Protein Synthesis Inhibitors/metabolism ; RNA, Bacterial/chemistry ; RNA, Bacterial/genetics ; RNA, Bacterial/metabolism ; RNA, Transfer, Met/chemistry ; RNA, Transfer, Met/genetics ; RNA, Transfer, Met/metabolism ; RNA, Transfer, Phe/chemistry ; RNA, Transfer, Phe/genetics ; RNA, Transfer, Phe/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Ribosomes/ultrastructure ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
Global phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control.
Autorzy :
Dokládal L; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Stumpe M; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Pillet B; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Hu Z; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Garcia Osuna GM; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Kressler D; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Dengjel J; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
De Virgilio C; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 May 06; Vol. 81 (9), pp. 1879-1889.e6. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Proteomics*
Amino Acids/*deficiency
Protein Serine-Threonine Kinases/*metabolism
Saccharomyces cerevisiae/*enzymology
Saccharomyces cerevisiae Proteins/*metabolism
Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Feedback, Physiological ; Gene Expression Regulation, Fungal ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; RNA, Transfer, Met/genetics ; RNA, Transfer, Met/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
The dynamic cycle of bacterial translation initiation factor IF3.
Autorzy :
Nakamoto JA; Laboratory of Applied Biophysics and Biochemistry, Centre for Research and Innovation, Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas (UPC), Lima 15023, Peru.
Evangelista W; Laboratory of Applied Biophysics and Biochemistry, Centre for Research and Innovation, Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas (UPC), Lima 15023, Peru.
Vinogradova DS; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', Gatchina 188300, Russia.; NanoTemper Technologies Rus, Saint Petersburg 191167, Russia.
Konevega AL; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', Gatchina 188300, Russia.; NRC 'Kurchatov Institute', Moscow 123182, Russia.; Peter the Great St. Petersburg Polytechnic University, Saint Petersburg 195251, Russia.
Spurio R; Laboratory of Genetics, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino 62032, Italy.
Fabbretti A; Laboratory of Genetics, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino 62032, Italy.
Milón P; Laboratory of Applied Biophysics and Biochemistry, Centre for Research and Innovation, Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas (UPC), Lima 15023, Peru.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 09; Vol. 49 (12), pp. 6958-6970.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Initiation, Translational*
Bacterial Proteins/*metabolism
Prokaryotic Initiation Factor-3/*metabolism
Bacterial Proteins/chemistry ; Binding Sites ; Fluorescence Resonance Energy Transfer ; Kinetics ; Models, Molecular ; Prokaryotic Initiation Factor-1/metabolism ; Prokaryotic Initiation Factor-2/metabolism ; Prokaryotic Initiation Factor-3/chemistry ; Protein Binding ; Protein Conformation ; Protein Domains ; RNA, Transfer, Met/metabolism ; Ribosome Subunits, Small, Bacterial/metabolism
Czasopismo naukowe
Tytuł :
A novel pathogenic m.4412G>A MT-TM mitochondrial DNA variant associated with childhood-onset seizures, myopathy and bilateral basal ganglia changes.
Autorzy :
Lim AZ; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Blakely EL; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4HH, UK.
Baty K; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4HH, UK.
He L; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4HH, UK.
Hopton S; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4HH, UK.
Falkous G; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4HH, UK.
McWilliam K; Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh EH9 1LF, UK.
Cozens A; Inherited Metabolic Disorders Scotland, NHS National Services Scotland, Glasgow G2 6QE, UK.
McFarland R; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Taylor RW; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4HH, UK. Electronic address: .
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Źródło :
Mitochondrion [Mitochondrion] 2019 Jul; Vol. 47, pp. 18-23. Date of Electronic Publication: 2019 Apr 22.
Typ publikacji :
Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basal Ganglia*/metabolism
Basal Ganglia*/pathology
DNA, Mitochondrial*/genetics
DNA, Mitochondrial*/metabolism
Mitochondrial Myopathies*/genetics
Mitochondrial Myopathies*/metabolism
Mitochondrial Myopathies*/pathology
Mitochondrial Myopathies*/physiopathology
Point Mutation*
Seizures*/genetics
Seizures*/metabolism
Seizures*/pathology
Seizures*/physiopathology
RNA, Mitochondrial/*genetics
RNA, Transfer, Met/*genetics
Child ; Female ; Humans ; RNA, Mitochondrial/metabolism ; RNA, Transfer, Met/metabolism
Czasopismo naukowe
Tytuł :
The structural basis of translational control by eIF2 phosphorylation.
Autorzy :
Adomavicius T; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.
Guaita M; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.
Zhou Y; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.; The Jenner Institute, Old Road Campus Research Building Roosevelt Drive, Oxford, OX3 7DQ, UK.
Jennings MD; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.
Latif Z; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Roseman AM; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK. .
Pavitt GD; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK. .
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Źródło :
Nature communications [Nat Commun] 2019 May 13; Vol. 10 (1), pp. 2136. Date of Electronic Publication: 2019 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eukaryotic Initiation Factor-2/*ultrastructure
Eukaryotic Initiation Factor-2B/*ultrastructure
RNA, Transfer, Met/*ultrastructure
Saccharomyces cerevisiae Proteins/*ultrastructure
Computer Simulation ; Cryoelectron Microscopy ; Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factor-2B/metabolism ; Models, Molecular ; Nucleotides/metabolism ; Phosphorylation/physiology ; Protein Binding/physiology ; Protein Biosynthesis/physiology ; RNA, Transfer, Met/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
In vivo structure of the Ty1 retrotransposon RNA genome.
Autorzy :
Andrzejewska A; Department of Structure and Function of Retrotransposons, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Zawadzka M; Department of Structure and Function of Retrotransposons, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Gumna J; Department of Structure and Function of Retrotransposons, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Garfinkel DJ; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Pachulska-Wieczorek K; Department of Structure and Function of Retrotransposons, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2878-2893.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Retroelements*
RNA, Viral/*chemistry
Base Pairing ; Dimerization ; Nucleic Acid Conformation ; Protein Biosynthesis ; RNA, Transfer, Met/metabolism ; RNA, Viral/metabolism ; Saccharomyces/virology ; Terminal Repeat Sequences
Czasopismo naukowe
Tytuł :
Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNA .
Autorzy :
Franco LVR; Departamento de Microbiologia - Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
Moda BS; Departamento de Microbiologia - Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
Soares MAKM; Departamento de Microbiologia - Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
Barros MH; Departamento de Microbiologia - Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
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Źródło :
The FEBS journal [FEBS J] 2019 Apr; Vol. 286 (7), pp. 1407-1419. Date of Electronic Publication: 2019 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Initiation, Translational*
Protein Processing, Post-Translational*
RNA, Transfer, Met*
Mitochondria/*metabolism
RNA, Transfer/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Eukaryotic Initiation Factors/genetics ; Eukaryotic Initiation Factors/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Rapid formylation of the cellular initiator tRNA population makes a crucial contribution to its exclusive participation at the step of initiation.
Autorzy :
Shah RA; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Varada R; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Sah S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Shetty S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Lahry K; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Singh S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Varshney U; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Feb 28; Vol. 47 (4), pp. 1908-1919.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Conformation*
Anticodon/*genetics
RNA, Transfer, Met/*chemistry
Ribosomes/*chemistry
Anticodon/chemistry ; Escherichia coli/chemistry ; Escherichia coli/genetics ; Plasmids/genetics ; RNA, Transfer, Met/genetics ; Ribosome Subunits, Small, Bacterial/chemistry ; Ribosome Subunits, Small, Bacterial/genetics ; Ribosomes/genetics
Czasopismo naukowe
Tytuł :
MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2.
Autorzy :
Young-Baird SK; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.; National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
Shin BS; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Dever TE; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Jan 25; Vol. 47 (2), pp. 855-867.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Mutation*
Epilepsy/*genetics
Eukaryotic Initiation Factor-2/*genetics
Genitalia/*abnormalities
Hypogonadism/*genetics
Mental Retardation, X-Linked/*genetics
Microcephaly/*genetics
Obesity/*genetics
RNA, Transfer, Met/*metabolism
Saccharomyces cerevisiae Proteins/*genetics
Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Codon, Initiator ; Eukaryotic Initiation Factor-2/chemistry ; HEK293 Cells ; Humans ; RNA, Transfer, Met/chemistry ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/metabolism
SCR Disease Name :
MEHMO syndrome
Czasopismo naukowe
Tytuł :
eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.
Autorzy :
Kim E; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.
Kim JH; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.
Seo K; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.
Hong KY; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.
An SWA; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.
Kwon J; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.
Lee SV; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea.
Jang SK; PBC, Department of Life Sciences, Pohang University of Science and Technology, Cheongam-ro 77, Nam-gu, Pohang-si, Gyeongsangbuk-do, 37673, Republic of Korea. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2018 Dec; Vol. 75 (23), pp. 4287-4300. Date of Electronic Publication: 2018 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Caenorhabditis elegans Proteins/*metabolism
Eukaryotic Initiation Factor-2/*metabolism
Eukaryotic Initiation Factors/*metabolism
RNA, Transfer, Met/*metabolism
eIF-2 Kinase/*metabolism
Amino Acid Sequence ; Animals ; Blotting, Western ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factors/genetics ; HEK293 Cells ; Humans ; Mutation ; Protein Binding ; RNA Interference ; RNA, Transfer, Met/genetics ; Sequence Homology, Amino Acid ; eIF-2 Kinase/genetics
Czasopismo naukowe
Tytuł :
Sustenance of Escherichia coli on a single tRNAMet.
Autorzy :
Govindan A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Ayyub SA; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Varshney U; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2018 Nov 30; Vol. 46 (21), pp. 11566-11574.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
RNA, Transfer, Met*
Escherichia coli/*genetics
Base Pairing ; Escherichia coli/growth & development ; Escherichia coli Proteins/genetics ; Peptide Chain Initiation, Translational ; Peptide Elongation Factor Tu/genetics ; Prokaryotic Initiation Factor-2/genetics
Czasopismo naukowe
Tytuł :
SARS-CoV-2 has the advantage of competing the iMet-tRNAs with human hosts to allow efficient translation.
Autorzy :
Wang Y; Department of Respiration, Qingdao Central Hospital, Qingdao, China.
Gai Y; Department of Respiration, Qingdao Central Hospital, Qingdao, China.
Li Y; Department of Respiration, Qingdao Central Hospital, Qingdao, China.
Li C; Department of Respiration, Qingdao Central Hospital, Qingdao, China.
Li Z; Department of Respiration, Qingdao Central Hospital, Qingdao, China.
Wang X; Department of Respiration, Qingdao Central Hospital, Qingdao, China. .
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Źródło :
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2021 Jan; Vol. 296 (1), pp. 113-118. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Peptide Chain Initiation, Translational*
RNA, Transfer, Met/*metabolism
SARS-CoV-2/*physiology
COVID-19/virology ; Codon ; Evolution, Molecular ; Genome, Human ; Host-Pathogen Interactions ; Humans ; Mutation ; Protein Biosynthesis ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł :
Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex.
Autorzy :
Wang J; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Wang J; Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, NY, USA.
Shin BS; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Kim JR; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Dever TE; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA. .
Puglisi JD; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. .
Fernández IS; Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 06; Vol. 11 (1), pp. 5003. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Peptide Chain Elongation, Translational*
Peptide Chain Initiation, Translational*
Eukaryotic Initiation Factors/*chemistry
Eukaryotic Initiation Factors/*metabolism
Ribosome Subunits, Large/*metabolism
Acylation ; Anticodon ; Cryoelectron Microscopy ; Eukaryotic Initiation Factors/genetics ; Guanosine Diphosphate/metabolism ; Models, Molecular ; Nucleic Acid Conformation ; RNA, Transfer, Met/chemistry ; RNA, Transfer, Met/metabolism ; Ribosome Subunits, Large/chemistry ; Ribosome Subunits, Large/genetics ; Ribosome Subunits, Large, Eukaryotic ; Ribosome Subunits, Small, Eukaryotic ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Serine/metabolism
Czasopismo naukowe
Tytuł :
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.
Autorzy :
Minton DR; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
Nam M; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
McLaughlin DJ; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
Shin J; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
Bayraktar EC; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Alvarez SW; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
Sviderskiy VO; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
Papagiannakopoulos T; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
Sabatini DM; Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, MA 02142, USA.
Birsoy K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: .
Possemato R; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2018 Feb 15; Vol. 69 (4), pp. 610-621.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Initiation, Translational*
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Glycine Hydroxymethyltransferase/*metabolism
Mitochondria/*genetics
RNA, Transfer, Met/*chemistry
Serine/*chemistry
Animals ; Apoptosis ; Breast Neoplasms/metabolism ; CRISPR-Cas Systems ; Cell Proliferation ; Cytosol/metabolism ; Female ; Glycine Hydroxymethyltransferase/antagonists & inhibitors ; Glycine Hydroxymethyltransferase/genetics ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mitochondria/drug effects ; Mitochondria/metabolism ; Protein Processing, Post-Translational ; RNA, Transfer, Met/genetics ; RNA, Transfer, Met/metabolism ; Serine/genetics ; Serine/metabolism ; Tetrahydrofolates/pharmacology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
miR-34a directly targets tRNA i precursors and affects cellular proliferation, cell cycle, and apoptosis.
Autorzy :
Wang B; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.; Department of Biochemistry, Qiqihar Medical University, Qiqihar, 161006 Heilongjiang, China.
Li D; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.
Kovalchuk I; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.
Apel IJ; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Chinnaiyan AM; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Wóycicki RK; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.
Cantor CR; Department of Biomedical Engineering, Boston University, Boston, MA 02215 .
Kovalchuk O; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 10; Vol. 115 (28), pp. 7392-7397. Date of Electronic Publication: 2018 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Gene Expression Regulation, Neoplastic*
RNA Processing, Post-Transcriptional*
Breast Neoplasms/*metabolism
MicroRNAs/*biosynthesis
RNA Precursors/*biosynthesis
RNA, Neoplasm/*biosynthesis
RNA, Transfer, Met/*biosynthesis
Argonaute Proteins/genetics ; Argonaute Proteins/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Cycle ; Female ; Humans ; MCF-7 Cells ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; RNA Precursors/genetics ; RNA, Neoplasm/genetics ; RNA, Transfer, Met/genetics
Czasopismo naukowe
Tytuł :
Mutations in MARS identified in a specific type of pulmonary alveolar proteinosis alter methionyl-tRNA synthetase activity.
Autorzy :
Comisso M; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
Hadchouel A; Service de Pneumologie et d'Allergologie Pédiatriques, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.; U955, Equipe 4, INSERM, Créteil, France.; Université Paris Descartes-Sorbonne Paris Cité, France.
de Blic J; Service de Pneumologie et d'Allergologie Pédiatriques, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.; Université Paris Descartes-Sorbonne Paris Cité, France.
Mirande M; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
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Źródło :
The FEBS journal [FEBS J] 2018 Jul; Vol. 285 (14), pp. 2654-2661. Date of Electronic Publication: 2018 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Methionine/*chemistry
Methionine-tRNA Ligase/*chemistry
Pulmonary Alveolar Proteinosis/*metabolism
RNA, Transfer, Met/*metabolism
Amino Acid Sequence ; Animals ; Binding Sites ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Methionine/metabolism ; Methionine-tRNA Ligase/genetics ; Methionine-tRNA Ligase/metabolism ; Models, Molecular ; Mutagenesis, Site-Directed ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Pulmonary Alveolar Proteinosis/genetics ; Pulmonary Alveolar Proteinosis/pathology ; RNA, Transfer, Met/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Substrate Specificity ; Transfer RNA Aminoacylation
Czasopismo naukowe

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