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Tytuł :
The gammaherpesviral TATA-box-binding protein directly interacts with the CTD of host RNA Pol II to direct late gene transcription.
Autorzy :
Castañeda AF; Department of Plant and Microbial Biology, University of California, Berkeley, CA, United States of America.
Didychuk AL; Department of Plant and Microbial Biology, University of California, Berkeley, CA, United States of America.
Louder RK; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States of America.; Biophysics Graduate Group, University of California, Berkeley, CA, United States of America.
McCollum CO; Department of Molecular and Cell Biology, University of California Berkeley, CA, United States of America.
Davis ZH; Division of Infectious Diseases and Immunity, School of Public Health, University of California, Berkeley, CA, United States of America.
Nogales E; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States of America.; Department of Molecular and Cell Biology, University of California Berkeley, CA, United States of America.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA, United States of America.; Howard Hughes Medical Institute, Berkeley, CA, United States of America.
Glaunsinger BA; Department of Plant and Microbial Biology, University of California, Berkeley, CA, United States of America.; Department of Molecular and Cell Biology, University of California Berkeley, CA, United States of America.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA, United States of America.; Howard Hughes Medical Institute, Berkeley, CA, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 04; Vol. 16 (9), pp. e1008843. Date of Electronic Publication: 2020 Sep 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Herpesvirus 8, Human/*metabolism
RNA Polymerase II/*metabolism
TATA-Box Binding Protein/*metabolism
Viral Proteins/*metabolism
Amino Acid Motifs ; HEK293 Cells ; Herpesvirus 8, Human/genetics ; Humans ; Protein Binding ; Protein Domains ; RNA Polymerase II/genetics ; TATA-Box Binding Protein/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
A G(enomic)P(ositioning)S(ystem) for Plant RNAPII Transcription.
Autorzy :
Leng X; Copenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, Bülowsvej 34, 1870 Frederiksberg C, Denmark.
Thomas Q; Copenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, Bülowsvej 34, 1870 Frederiksberg C, Denmark.
Rasmussen SH; Copenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, Bülowsvej 34, 1870 Frederiksberg C, Denmark.
Marquardt S; Copenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, Bülowsvej 34, 1870 Frederiksberg C, Denmark. Electronic address: .
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Źródło :
Trends in plant science [Trends Plant Sci] 2020 Aug; Vol. 25 (8), pp. 744-764. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Arabidopsis*/genetics
Arabidopsis*/metabolism
RNA Polymerase II*/genetics
RNA Polymerase II*/metabolism
Histones/genetics ; Histones/metabolism ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation.
Autorzy :
Yague-Sanz C; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
Vanrobaeys Y; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
Fernandez R; Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, Connecticut 06520, USA.; Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Duval M; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
Larochelle M; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
Beaudoin J; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
Berro J; Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, Connecticut 06520, USA.; Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Labbé S; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
Jacques PÉ; Department of Biology, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada.
Bachand F; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
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Źródło :
Genes & development [Genes Dev] 2020 Jul 01; Vol. 34 (13-14), pp. 883-897. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation/*drug effects
RNA Polymerase II/*genetics
Schizosaccharomyces/*enzymology
Schizosaccharomyces/*genetics
Enzyme Activation/drug effects ; Genes, Fungal/genetics ; Mutation ; Peptide Chain Elongation, Translational/drug effects ; Phosphates/pharmacology ; Polyadenylation ; Promoter Regions, Genetic/genetics ; RNA Polymerase II/chemistry ; RNA Polymerase II/metabolism ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
JMJD5 couples with CDK9 to release the paused RNA polymerase II.
Autorzy :
Liu H; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Ramachandran S; RNA Bioscience Initiative and Department of Genetics and Biochemistry, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Fong N; RNA Bioscience Initiative and Department of Genetics and Biochemistry, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Phang T; Department of Biostatistics and Informatics, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Lee S; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Parsa P; NanoTemper Technologies, Inc., South San Francisco, CA 94080.
Liu X; Department of Hematology, Duke University, Durham, NC 27710.
Harmacek L; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Danhorn T; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Song T; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Oh S; Department of Cell Biology, University of Oklahoma, Oklahoma City, OK 73104.
Zhang Q; School of Life Science, China Agricultural University, 100101 Beijing, People's Republic of China.
Chen Z; School of Life Science, China Agricultural University, 100101 Beijing, People's Republic of China.
Zhang Q; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
Tu TH; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Happoldt C; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
O'Conner B; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Janknecht R; Department of Cell Biology, University of Oklahoma, Oklahoma City, OK 73104.
Li CY; Department of Hematology, Duke University, Durham, NC 27710.
Marrack P; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Kappler J; Department of Biomedical Research, National Jewish Health, Denver, CO 80206; .; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Leach S; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Zhang G; Department of Biomedical Research, National Jewish Health, Denver, CO 80206; .; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 18; Vol. 117 (33), pp. 19888-19895. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Cyclin-Dependent Kinase 9/*metabolism
Histone Demethylases/*metabolism
RNA Polymerase II/*metabolism
Cell Line, Tumor ; Cyclin-Dependent Kinase 9/genetics ; Histone Demethylases/chemistry ; Histone Demethylases/genetics ; Humans ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Phosphorylation ; Positive Transcriptional Elongation Factor B/genetics ; Positive Transcriptional Elongation Factor B/metabolism ; Promoter Regions, Genetic ; Protein Binding ; Protein Domains ; RNA Polymerase II/genetics
Czasopismo naukowe
Tytuł :
Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors.
Autorzy :
Parua PK; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fisher RP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Jul; Vol. 16 (7), pp. 716-724. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Cyclin-Dependent Kinases/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
RNA Polymerase II/*genetics
Small Molecule Libraries/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/genetics ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Disease Models, Animal ; Humans ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/pathology ; Proteasome Endopeptidase Complex/metabolism ; Protein Kinase Inhibitors/chemistry ; Proteolysis ; RNA Polymerase II/antagonists & inhibitors ; RNA Polymerase II/metabolism ; Signal Transduction ; Small Molecule Libraries/chemistry ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs.
Autorzy :
Bacon CW; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Biological Chemistry Graduate Program, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Challa A; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Hyder U; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Shukla A; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Borkar AN; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Bayo J; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET, Universidad Austral, Derqui-Pilar, Buenos Aires 1629, Argentina.
Liu J; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Wu SY; Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chiang CM; Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kutateladze TG; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
D'Orso I; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jun 18; Vol. 78 (6), pp. 1133-1151.e14. Date of Electronic Publication: 2020 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
RNA Polymerase II/*metabolism
Tripartite Motif-Containing Protein 28/*metabolism
Acetylation ; Cell Line, Tumor ; Chromatin/genetics ; Chromatin/metabolism ; Cyclin-Dependent Kinase 9/metabolism ; Gene Expression Regulation/genetics ; Histones/metabolism ; Humans ; Oncogenes/genetics ; Promoter Regions, Genetic/genetics ; Protein Processing, Post-Translational/genetics ; RNA Polymerase II/genetics ; Smad2 Protein/metabolism ; Transcription Factors/metabolism ; Transcription, Genetic ; Tripartite Motif-Containing Protein 28/genetics
Czasopismo naukowe
Tytuł :
Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II.
Autorzy :
Parua PK; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
Kalan S; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
Benjamin B; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
Sansó M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
Fisher RP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 28; Vol. 11 (1), pp. 4338. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cyclin-Dependent Kinase 9/*metabolism
RNA Polymerase II/*metabolism
Transcription, Genetic/*physiology
Cyclin-Dependent Kinase 9/antagonists & inhibitors ; HCT116 Cells ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphorylation ; Positive Transcriptional Elongation Factor B/metabolism ; RNA Interference ; RNA Polymerase II/genetics ; Receptors, Neuropeptide Y/metabolism ; Transcriptional Elongation Factors/genetics ; Transcriptional Elongation Factors/metabolism
Czasopismo naukowe
Tytuł :
CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation.
Autorzy :
Tellier M; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Zaborowska J; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Caizzi L; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 Göttingen, Germany.
Mohammad E; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 Göttingen, Germany.
Velychko T; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 Göttingen, Germany.
Schwalb B; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 Göttingen, Germany.
Ferrer-Vicens I; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Blears D; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nojima T; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Cramer P; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 Göttingen, Germany.
Murphy S; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Aug 20; Vol. 48 (14), pp. 7712-7727.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Elongation, Genetic*
Cyclin-Dependent Kinases/*physiology
RNA Polymerase II/*metabolism
Chromatin/metabolism ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; HEK293 Cells ; Humans ; Mutation ; Phosphorylation ; RNA/biosynthesis ; RNA Polymerase II/chemistry ; Sequence Analysis, RNA ; Serine/metabolism ; Transcriptional Elongation Factors/metabolism
Czasopismo naukowe
Tytuł :
Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates.
Autorzy :
Turowski TW; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK. Electronic address: .
Petfalski E; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.
Goddard BD; School of Mathematics and Maxwell Institute for Mathematical Sciences, The University of Edinburgh, Edinburgh, UK.
French SL; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Helwak A; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.
Tollervey D; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 06; Vol. 79 (3), pp. 488-503.e11. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Elongation, Genetic*
RNA Polymerase I/*genetics
RNA Polymerase II/*genetics
RNA Polymerase III/*genetics
RNA, Fungal/*chemistry
Saccharomyces cerevisiae/*genetics
Base Composition ; Base Sequence ; Binding Sites ; Chromatin/chemistry ; Chromatin/metabolism ; DNA, Ribosomal/genetics ; DNA, Ribosomal/metabolism ; Gene Expression Regulation, Fungal ; Protein Binding ; RNA Folding ; RNA Polymerase I/metabolism ; RNA Polymerase II/metabolism ; RNA Polymerase III/metabolism ; RNA Splice Sites ; RNA Splicing ; RNA, Fungal/genetics ; RNA, Fungal/metabolism ; Saccharomyces cerevisiae/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Primary Role of the Nucleosome.
Autorzy :
Kornberg RD; Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA.
Lorch Y; Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 06; Vol. 79 (3), pp. 371-375.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Transcription, Genetic*
Chromosomal Proteins, Non-Histone/*genetics
Nucleosomes/*metabolism
RNA Polymerase II/*genetics
Saccharomyces cerevisiae/*genetics
Transcription Factors/*genetics
Animals ; Binding Sites ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/metabolism ; Evolution, Molecular ; Gene Expression Regulation ; Histones/genetics ; Histones/metabolism ; Humans ; Nucleosomes/ultrastructure ; Promoter Regions, Genetic ; RNA Polymerase II/metabolism ; Saccharomyces cerevisiae/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
RNA Pol II Length and Disorder Enable Cooperative Scaling of Transcriptional Bursting.
Autorzy :
Quintero-Cadena P; California Institute of Technology, Division of Biology and Biological Engineering, Pasadena, CA, USA.
Lenstra TL; The Netherlands Cancer Institute, Oncode Institute, Division of Gene Regulation, Amsterdam, the Netherlands.
Sternberg PW; California Institute of Technology, Division of Biology and Biological Engineering, Pasadena, CA, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jul 16; Vol. 79 (2), pp. 207-220.e8. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
Transcription, Genetic*
RNA Polymerase II/*metabolism
Saccharomycetales/*enzymology
Saccharomycetales/*genetics
Amino Acid Sequence ; Models, Genetic ; RNA Polymerase II/chemistry ; RNA-Seq ; Structure-Activity Relationship ; Transcriptome
Czasopismo naukowe
Tytuł :
Tyrosine kinase inhibitors induce alternative spliced BCR-ABL variant via inhibition of RNA polymerase II on genomic BCR-ABL.
Autorzy :
Yuda J; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Odawara J; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Minami M; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Muta T; Department of Hematology and Oncology, Japan Community Health Care Organization Kyushu Hospital, Fukuoka, Japan.
Kohno K; Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Tanimoto K; Department of Haematology and Oncology, Japanese Red Cross Society Fukuoka Red Cross Hospital, Fukuoka, Japan.
Eto T; Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
Shima T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Kikushige Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Kato K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Takenaka K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Iwasaki H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Minami Y; Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan.
Ohkawa Y; Department of Advanced Medical Initiatives, Kyushu University, Fukuoka, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Jul; Vol. 111 (7), pp. 2361-2373. Date of Electronic Publication: 2020 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Mutation*
Fusion Proteins, bcr-abl/*genetics
Protein Kinase Inhibitors/*pharmacology
RNA Polymerase II/*metabolism
Adult ; Aged ; Female ; Gene Expression Regulation, Leukemic/drug effects ; Genetic Loci ; High-Throughput Nucleotide Sequencing ; Humans ; Introns ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Male ; Middle Aged ; Protein Kinase Inhibitors/therapeutic use ; RNA Polymerase II/antagonists & inhibitors ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
Autorzy :
Vos SM; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany.; Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
Farnung L; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany.
Linden A; Max Planck Institute for Biophysical Chemistry, Bioanalytical Mass Spectrometry, Göttingen, Germany.; University Medical Center Göttingen, Institute of Clinical Chemistry, Bioanalytics Group, Göttingen, Germany.
Urlaub H; Max Planck Institute for Biophysical Chemistry, Bioanalytical Mass Spectrometry, Göttingen, Germany.; University Medical Center Göttingen, Institute of Clinical Chemistry, Bioanalytics Group, Göttingen, Germany.
Cramer P; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Jul; Vol. 27 (7), pp. 668-677. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Multiprotein Complexes/*chemistry
RNA Polymerase II/*metabolism
Transcription Factors/*chemistry
Allosteric Regulation ; Cryoelectron Microscopy ; Humans ; Models, Molecular ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Nuclear Proteins/chemistry ; Nuclear Proteins/metabolism ; Protein Binding ; Protein Conformation ; RNA Polymerase II/chemistry ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Transcriptional Elongation Factors/chemistry ; Transcriptional Elongation Factors/metabolism
Czasopismo naukowe
Tytuł :
TFIID Enables RNA Polymerase II Promoter-Proximal Pausing.
Autorzy :
Fant CB; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Levandowski CB; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Gupta K; School of Biochemistry, Bristol Research Centre for Synthetic Biology, University of Bristol, Bristol, UK.
Maas ZL; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Moir J; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Rubin JD; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Sawyer A; Department of Biology, Brandeis University, Waltham, MA, USA.
Esbin MN; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Rimel JK; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Luyties O; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Marr MT; Department of Biology, Brandeis University, Waltham, MA, USA.
Berger I; School of Biochemistry, Bristol Research Centre for Synthetic Biology, University of Bristol, Bristol, UK.
Dowell RD; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Taatjes DJ; Department of Biochemistry, University of Colorado, Boulder, CO, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 May 21; Vol. 78 (4), pp. 785-793.e8. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Promoter Regions, Genetic*
Transcription, Genetic*
Drosophila/*metabolism
Drosophila Proteins/*metabolism
RNA Polymerase II/*genetics
Transcription Factor TFIID/*metabolism
Animals ; Drosophila/genetics ; Drosophila Proteins/genetics ; HCT116 Cells ; Humans ; Protein Binding ; RNA Polymerase II/metabolism ; Transcription Factor TFIID/genetics
Czasopismo naukowe
Tytuł :
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Autorzy :
Nakazawa Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hara Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Oka Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Komine O; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
van den Heuvel D; Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
Guo C; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Daigaku Y; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan; Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Isono M; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
He Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shimada M; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kato K; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Jia N; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hashimoto S; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kotani Y; Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan; Genome Editing Research and Development (R&D) Center, Graduate School of Medicine, Osaka University, Osaka, Japan.
Miyoshi Y; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tanaka M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sobue A; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Mitsutake N; Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Suganami T; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masuda A; Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ohno K; Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nakada S; Department of Bioregulation and Cellular Response, Graduate School of Medicine, Osaka University, Osaka, Japan; Institute for Advanced Co-Creation Studies, Osaka University, Osaka, Japan.
Mashimo T; Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan; Genome Editing Research and Development (R&D) Center, Graduate School of Medicine, Osaka University, Osaka, Japan; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yamanaka K; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Luijsterburg MS; Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
Ogi T; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: .
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Źródło :
Cell [Cell] 2020 Mar 19; Vol. 180 (6), pp. 1228-1244.e24. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair/*physiology
RNA Polymerase II/*metabolism
Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; DNA/metabolism ; DNA Damage/physiology ; DNA Helicases/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Female ; HCT116 Cells ; HEK293 Cells ; HeLa Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA Polymerase II/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
Gene-Specific Control of tRNA Expression by RNA Polymerase II.
Autorzy :
Gerber A; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HZ Amsterdam, Netherlands. Electronic address: .
Ito K; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Chu CS; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Roeder RG; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 May 21; Vol. 78 (4), pp. 765-778.e7. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Transcription, Genetic*
RNA Polymerase II/*metabolism
RNA Polymerase III/*metabolism
RNA, Transfer/*metabolism
Repressor Proteins/*metabolism
Retinol-Binding Proteins, Cellular/*metabolism
HeLa Cells ; Humans ; Protein Processing, Post-Translational ; RNA Polymerase II/genetics ; RNA Polymerase III/genetics ; RNA, Transfer/genetics ; Repressor Proteins/genetics ; Retinol-Binding Proteins, Cellular/genetics
Czasopismo naukowe
Tytuł :
The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS.
Autorzy :
Bae HJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Dubarry M; Cancer Research Center of Marseille (CRCM), U1068 Inserm, UMR7258 CNRS, Aix Marseille University (AMU), Institut Paoli-Calmettes. Equipe labellisée Ligue contre le cancer, Marseille, 13009, France.
Jeon J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Soares LM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Foghorn Therapeutics, Cambridge, MA, 02142, USA.
Dargemont C; Institute of Human Genetics, UMR 9002 CNRS, Montpellier, 34396, France.
Kim J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Geli V; Cancer Research Center of Marseille (CRCM), U1068 Inserm, UMR7258 CNRS, Aix Marseille University (AMU), Institut Paoli-Calmettes. Equipe labellisée Ligue contre le cancer, Marseille, 13009, France. .
Buratowski S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 May 01; Vol. 11 (1), pp. 2181. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*metabolism
Histone-Lysine N-Methyltransferase/*metabolism
RNA Polymerase II/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Chromatin Immunoprecipitation Sequencing ; Histone-Lysine N-Methyltransferase/genetics ; Histones/chemistry ; Histones/metabolism ; Lysine/metabolism ; Methylation ; Point Mutation ; Protein Binding ; Protein Domains ; Protein Processing, Post-Translational ; RNA Polymerase II/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-π and CH-π interactions.
Autorzy :
Oh J; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093.; Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093.
Fleming AM; Department of Chemistry, University of Utah, Salt Lake City, UT 84112.
Xu J; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093.; Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093.
Chong J; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093.; Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093.
Burrows CJ; Department of Chemistry, University of Utah, Salt Lake City, UT 84112.
Wang D; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093; .; Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 28; Vol. 117 (17), pp. 9338-9348. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Guanidines/*chemistry
Guanosine/*analogs & derivatives
Hydantoins/*chemistry
RNA Polymerase II/*metabolism
Spiro Compounds/*chemistry
Base Pairing ; DNA/chemistry ; DNA/metabolism ; DNA Damage/physiology ; DNA Repair/physiology ; Guanidines/metabolism ; Guanine/metabolism ; Guanosine/chemistry ; Guanosine/metabolism ; Hydantoins/metabolism ; Oxidation-Reduction ; Oxidative Stress/physiology ; Purines/metabolism ; RNA Polymerase II/physiology ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Spiro Compounds/metabolism ; Transcription, Genetic/physiology ; Transcriptional Activation/physiology
Czasopismo naukowe
Tytuł :
Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II.
Autorzy :
Li M; Departments of Internal Medicine and Epidemiology, University of Iowa and Iowa City Veterans Affairs Health Care System, Iowa City, IA, United States of America.; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Ball CB; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Collins G; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Hu Q; Departments of Internal Medicine and Epidemiology, University of Iowa and Iowa City Veterans Affairs Health Care System, Iowa City, IA, United States of America.
Luse DS; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America.
Price DH; Department of Biochemistry, University of Iowa, Iowa City, IA, United States of America.
Meier JL; Departments of Internal Medicine and Epidemiology, University of Iowa and Iowa City Veterans Affairs Health Care System, Iowa City, IA, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Apr 06; Vol. 16 (4), pp. e1008402. Date of Electronic Publication: 2020 Apr 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Replication*
Promoter Regions, Genetic*
Cytomegalovirus/*metabolism
Cytomegalovirus Infections/*virology
Immediate-Early Proteins/*metabolism
RNA Polymerase II/*metabolism
Trans-Activators/*metabolism
Viral Proteins/*genetics
Cytomegalovirus/genetics ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/metabolism ; DNA, Viral/genetics ; Gene Expression Regulation, Viral ; Humans ; Immediate-Early Proteins/genetics ; RNA Polymerase II/genetics ; Trans-Activators/genetics ; Transcription Initiation, Genetic ; Viral Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation.
Autorzy :
Son K; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Schärer OD; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. Electronic address: .
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Źródło :
Cell [Cell] 2020 Mar 19; Vol. 180 (6), pp. 1039-1041.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
RNA Polymerase II*
Transcription, Genetic*
DNA Damage ; DNA Repair ; Ubiquitination
Czasopismo naukowe

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