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Wyszukujesz frazę ""RNA polymerase III"" wg kryterium: Temat


Tytuł :
Ex vivo visualization of RNA polymerase III-specific gene activity with electron microscopy.
Autorzy :
Manger S; Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
Ermel UH; Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
Frangakis AS; Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany. .
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Źródło :
Communications biology [Commun Biol] 2021 Feb 19; Vol. 4 (1), pp. 234. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Gene Editing*
Microscopy, Electron, Transmission*
Transcription, Genetic*
RNA Polymerase III/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Expression Regulation, Fungal ; Proof of Concept Study ; RNA Polymerase III/genetics ; RNA Polymerase III/ultrastructure ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Functional characterization of Polr3a hypomyelinating leukodystrophy mutations in the S. cerevisiae homolog, RPC160.
Autorzy :
Moir RD; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Lavados C; Graduate Program in Biomedical Science, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lee J; Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Willis IM; Departments of Biochemistry and Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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Źródło :
Gene [Gene] 2021 Feb 05; Vol. 768, pp. 145259. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
DNA-Binding Proteins/*biosynthesis
RNA Polymerase III/*genetics
RNA, Transfer/*biosynthesis
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae/*growth & development
DNA-Binding Proteins/genetics ; DNA-Directed RNA Polymerases/genetics ; Humans ; Pelizaeus-Merzbacher Disease/genetics ; RNA Polymerase III/metabolism ; RNA, Transfer/genetics ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Activation and repression at the heart of human RNA polymerase III.
Autorzy :
Lata E; University of Bordeaux, Inserm U1212, CNRS UMR5320, ARNA, Bordeaux, France.
Teichmann M; University of Bordeaux, Inserm U1212, CNRS UMR5320, ARNA, Bordeaux, France. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Feb; Vol. 28 (2), pp. 124-126.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
RNA Polymerase III*/genetics
Transcription, Genetic*
Humans ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Structural insights into transcriptional regulation of human RNA polymerase III.
Autorzy :
Wang Q; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Precision Medicine, Shanghai, China.
Li S; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Precision Medicine, Shanghai, China.
Wan F; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Precision Medicine, Shanghai, China.
Xu Y; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Wu Z; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Precision Medicine, Shanghai, China.
Cao M; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Precision Medicine, Shanghai, China.
Lan P; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .; Shanghai Institute of Precision Medicine, Shanghai, China. .
Lei M; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .; Shanghai Institute of Precision Medicine, Shanghai, China. .; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
Wu J; State Key Laboratory of Oncogenes and Related Genes, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .; Shanghai Institute of Precision Medicine, Shanghai, China. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Feb; Vol. 28 (2), pp. 220-227. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
RNA Polymerase III/*chemistry
Binding Sites ; Cryoelectron Microscopy ; HEK293 Cells ; Humans ; Protein Conformation ; RNA Polymerase III/ultrastructure ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Autorzy :
Girbig M; European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany.; Candidate for joint PhD degree from EMBL and Heidelberg University, Faculty of Biosciences, Heidelberg, Germany.
Misiaszek AD; European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany.; Candidate for joint PhD degree from EMBL and Heidelberg University, Faculty of Biosciences, Heidelberg, Germany.
Vorländer MK; European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany.
Lafita A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.
Grötsch H; European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany.
Baudin F; European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany.
Bateman A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.
Müller CW; European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Feb; Vol. 28 (2), pp. 210-219. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
RNA Polymerase III/*chemistry
Binding Sites ; Cryoelectron Microscopy ; HEK293 Cells ; Humans ; Protein Conformation ; RNA Polymerase III/ultrastructure ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Structure of human RNA polymerase III.
Autorzy :
Ramsay EP; Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK.
Abascal-Palacios G; Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK.
Daiß JL; Regensburg Center for Biochemistry, University of Regensburg, 93053, Regensburg, Germany.
King H; Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK.
Gouge J; Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK.
Pilsl M; Regensburg Center for Biochemistry, University of Regensburg, 93053, Regensburg, Germany.
Beuron F; Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK.
Morris E; Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK.
Gunkel P; Max Planck Institute for Biophysical Chemistry, Research Group Nuclear Architecture, 37077, Göttingen, Germany.
Engel C; Regensburg Center for Biochemistry, University of Regensburg, 93053, Regensburg, Germany. .
Vannini A; Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK. .; Fondazione Human Technopole, Structural Biology Research Centre, 20157, Milan, Italy. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 17; Vol. 11 (1), pp. 6409. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Polymerase III/*chemistry
Cryoelectron Microscopy ; DNA-Directed RNA Polymerases/genetics ; Enzyme Stability ; HeLa Cells ; Humans ; Models, Molecular ; Mutation ; Protein Conformation ; Protein Subunits ; RNA Polymerase III/genetics ; RNA Polymerase III/metabolism ; Scattering, Small Angle ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.
Autorzy :
Cieśla M; Department of Genetics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
Turowski TW; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh EH9 3BF, Scotland.
Nowotny M; Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, Ks. Trojdena 4, 02-109 Warsaw, Poland.
Tollervey D; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh EH9 3BF, Scotland.
Boguta M; Department of Genetics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 12252-12268.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
Genome, Fungal*
RNA Helicases/*genetics
RNA Polymerase III/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
3' Untranslated Regions ; Amino Acid Sequence ; Conserved Sequence ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Humans ; Nonsense Mediated mRNA Decay ; Protein Binding/radiation effects ; RNA Helicases/metabolism ; RNA Polymerase III/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Unique combination and in silico modeling of biallelic POLR3A variants as a cause of Wiedemann-Rautenstrauch syndrome.
Autorzy :
Temel SG; Bursa Uludag University, Faculty of Medicine, Department of Medical Genetics, Bursa, Turkey. .; Bursa Uludag University, Faculty of Medicine, Department of Histology and Embryology, Bursa, Turkey. .; Bursa Uludag University, Institute of Health Sciences, Department of Translational Medicine, Bursa, Turkey. .
Ergoren MC; Near East University, Faculty of Medicine, Department of Medical Biology, 99138, Nicosia, Cyprus.; Near East University, DESAM Insitute, 99138, Nicosia, Cyprus.
Manara E; MAGI Euregio, Bolzano, Italy.
Paolacci S; MAGI Euregio, Bolzano, Italy.
Tuncel G; Near East University, Faculty of Medicine, Department of Medical Biology, 99138, Nicosia, Cyprus.; Near East University, DESAM Insitute, 99138, Nicosia, Cyprus.
Gul S; Koc University, Faculty of Engineering, Department of Chemical and Biological Engineering, Istanbul, Turkey.
Bertelli M; MAGI's LAB S.r.l., Rovereto, Italy.
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Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2020 Dec; Vol. 28 (12), pp. 1675-1680. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Fetal Growth Retardation/*genetics
Progeria/*genetics
RNA Polymerase III/*genetics
Alleles ; Child ; Female ; Fetal Growth Retardation/pathology ; Humans ; Molecular Dynamics Simulation ; Mutation ; Progeria/pathology ; RNA Polymerase III/chemistry
SCR Disease Name :
Progeroid syndrome, neonatal
Czasopismo naukowe
Tytuł :
Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans.
Autorzy :
Hammerquist AM; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.; Department of Molecular and Computational Biology, Dornsife College of Letters, Arts, and Science, University of Southern California, Los Angeles, CA, USA.
Curran SP; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. .; Department of Molecular and Computational Biology, Dornsife College of Letters, Arts, and Science, University of Southern California, Los Angeles, CA, USA. .; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 09; Vol. 10 (1), pp. 19367. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
RNA Polymerase III/*metabolism
Repressor Proteins/*metabolism
Spermatids/*metabolism
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Male ; RNA Polymerase III/genetics ; Repressor Proteins/genetics
Czasopismo naukowe
Tytuł :
A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.
Autorzy :
Ramanathan A; Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Weintraub M; Brain Injury Clinic, Alyn Rehabilitation Hospital for Children, 91090 Jerusalem, Israel; .
Orlovetskie N; Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Serruya R; Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Mani D; Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Marcu O; Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Stepensky P; Pediatric Hematology-Oncology, Hadassah-Hebrew University Medical Center, 9112102 Jerusalem, Israel.
Weisblum Y; Department of Pathology and Immunology, The Lautenberg Center for Immunology and Cancer Research, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Djian E; Department of Pathology and Immunology, The Lautenberg Center for Immunology and Cancer Research, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Shaag A; Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, 9112102 Jerusalem, Israel.
Revel-Vilk S; Pediatric Hematology/Oncology Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.; The Hebrew University Hadassah Medical School, 9112102 Jerusalem, Israel.
Fried I; Pediatric Hematology/Oncology Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.
Kotler M; Department of Pathology and Immunology, The Lautenberg Center for Immunology and Cancer Research, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Rouvinski A; Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Wolf D; Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, 9112102 Jerusalem, Israel.
Elpeleg O; Department of Genetics, Hadassah-Hebrew University Medical Center, 9112102 Jerusalem, Israel .
Jarrous N; Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22113-22121. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cytomegalovirus/*physiology
Fibroblasts/*immunology
Fibroblasts/*virology
RNA Polymerase III/*metabolism
Animals ; Chlorocebus aethiops ; Cytomegalovirus/immunology ; Dendritic Cells ; Gene Expression Regulation, Enzymologic ; Humans ; Mutation ; RNA Polymerase III/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
From Rare Copy Number Variants to Biological Processes in ADHD.
Autorzy :
Harich B; Department of Human Genetics (Harich, van der Voet, Klein, Fenckova, Schenck, Franke) and Department of Psychiatry (Franke), Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; and Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (Čížek).
van der Voet M; Department of Human Genetics (Harich, van der Voet, Klein, Fenckova, Schenck, Franke) and Department of Psychiatry (Franke), Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; and Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (Čížek).
Klein M; Department of Human Genetics (Harich, van der Voet, Klein, Fenckova, Schenck, Franke) and Department of Psychiatry (Franke), Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; and Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (Čížek).
Čížek P; Department of Human Genetics (Harich, van der Voet, Klein, Fenckova, Schenck, Franke) and Department of Psychiatry (Franke), Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; and Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (Čížek).
Fenckova M; Department of Human Genetics (Harich, van der Voet, Klein, Fenckova, Schenck, Franke) and Department of Psychiatry (Franke), Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; and Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (Čížek).
Schenck A; Department of Human Genetics (Harich, van der Voet, Klein, Fenckova, Schenck, Franke) and Department of Psychiatry (Franke), Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; and Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (Čížek).
Franke B; Department of Human Genetics (Harich, van der Voet, Klein, Fenckova, Schenck, Franke) and Department of Psychiatry (Franke), Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; and Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (Čížek).
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Źródło :
The American journal of psychiatry [Am J Psychiatry] 2020 Sep 01; Vol. 177 (9), pp. 855-866. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Attention Deficit Disorder with Hyperactivity*/genetics
Attention Deficit Disorder with Hyperactivity*/metabolism
RNA Polymerase III*/genetics
RNA Polymerase III*/metabolism
RNA Splicing Factors*/genetics
RNA Splicing Factors*/metabolism
Brain/*metabolism
Gene Expression Profiling/*methods
DNA Copy Number Variations/physiology ; Databases, Genetic ; Genetic Association Studies/methods ; Genetic Predisposition to Disease ; Humans ; Protein Interaction Mapping/methods
Czasopismo naukowe
Tytuł :
A de novo variant of POLR3B causes demyelinating Charcot-Marie-Tooth disease in a Chinese patient: a case report.
Autorzy :
Xue YY; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, China.
Cheng HL; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, China.; Department of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Dong HL; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, China.
Yin HM; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, China.
Yuan Y; Department of Neurology, Peking University First Hospital, Beijing, China.
Meng LC; Department of Neurology, Peking University First Hospital, Beijing, China.
Wu ZY; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, China. .
Yu H; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, China. .
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Źródło :
BMC neurology [BMC Neurol] 2021 Oct 20; Vol. 21 (1), pp. 402. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Charcot-Marie-Tooth Disease*/genetics
Adult ; China ; Heterozygote ; Humans ; Male ; Mutation/genetics ; Phenotype ; RNA Polymerase III ; Young Adult
Czasopismo naukowe
Tytuł :
Interpretation challenges of novel dual-class missense and splice-impacting variant in POLR3A-related late-onset hereditary spastic ataxia.
Autorzy :
Morales-Rosado JA; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Macke EL; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Cousin MA; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Oliver GR; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Dhamija R; Department of Clinical Genomics, Mayo Clinic, Scottsdale, AZ, USA.; Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Klee EW; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
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Źródło :
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Sep; Vol. 8 (9), pp. e1341. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebellar Ataxia/*genetics
Genetic Testing/*standards
RNA Polymerase III/*genetics
Adult ; Cerebellar Ataxia/diagnostic imaging ; Cerebellar Ataxia/pathology ; Female ; Genetic Testing/methods ; Humans ; Mutation, Missense ; Phenotype ; RNA Polymerase III/metabolism ; RNA Splicing
Czasopismo naukowe
Tytuł :
Loss of Function of an RNA Polymerase III Subunit Leads to Impaired Maize Kernel Development.
Autorzy :
Zhao H; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Qin Y
Xiao Z; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Li Q; National Key Laboratory of Plant Molecular Genetics, Chinese Academy of Science Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology & Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Yang N; State Key Laboratory of Plant Genomics, National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
Pan Z; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Gong D; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Sun Q; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Yang F; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Zhang Z; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Wu Y; National Key Laboratory of Plant Molecular Genetics, Chinese Academy of Science Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology & Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Xu C; State Key Laboratory of Plant Genomics, National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
Qiu F; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China .
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Źródło :
Plant physiology [Plant Physiol] 2020 Sep; Vol. 184 (1), pp. 359-373. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Plant Proteins/*metabolism
RNA Polymerase III/*metabolism
Seeds/*growth & development
Seeds/*metabolism
Zea mays/*metabolism
CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/physiology ; Gene Expression Profiling ; Gene Expression Regulation, Plant/genetics ; Gene Expression Regulation, Plant/physiology ; Plant Proteins/genetics ; RNA Polymerase III/genetics ; Zea mays/genetics
Czasopismo naukowe
Tytuł :
The MAF1 Phosphoregulatory Region Controls MAF1 Interaction with the RNA Polymerase III C34 Subunit and Transcriptional Repression in Plants.
Autorzy :
Oliveira Andrade M; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, 13083-100 Campinas, São Paulo, Brazil.
Sforça ML; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, 13083-100 Campinas, São Paulo, Brazil.
Batista FAH; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, 13083-100 Campinas, São Paulo, Brazil.
Figueira ACM; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, 13083-100 Campinas, São Paulo, Brazil.
Benedetti CE; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, 13083-100 Campinas, São Paulo, Brazil .
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Źródło :
The Plant cell [Plant Cell] 2020 Sep; Vol. 32 (9), pp. 3019-3035. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Citrus/*genetics
Plant Proteins/*metabolism
RNA Polymerase III/*metabolism
Citrus/metabolism ; Gene Expression Regulation, Plant ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Protein Interaction Domains and Motifs ; Protein Subunits ; RNA Polymerase III/genetics ; Serine/metabolism ; Transcription, Genetic ; Yeasts/genetics
Czasopismo naukowe
Tytuł :
A small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes.
Autorzy :
Asif-Laidin A; INSERM U944, CNRS UMR 7212, Genomes& Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Université de Paris, Paris, France.
Conesa C; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Gif-sur-Yvette, France.
Bonnet A; INSERM U944, CNRS UMR 7212, Genomes& Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Université de Paris, Paris, France.
Grison C; INSERM U944, CNRS UMR 7212, Genomes& Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Université de Paris, Paris, France.
Adhya I; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Gif-sur-Yvette, France.
Menouni R; INSERM U944, CNRS UMR 7212, Genomes& Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Université de Paris, Paris, France.
Fayol H; INSERM U944, CNRS UMR 7212, Genomes& Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Université de Paris, Paris, France.
Palmic N; INSERM U944, CNRS UMR 7212, Genomes& Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Université de Paris, Paris, France.
Acker J; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Gif-sur-Yvette, France.
Lesage P; INSERM U944, CNRS UMR 7212, Genomes& Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Université de Paris, Paris, France.
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Źródło :
The EMBO journal [EMBO J] 2020 Sep 01; Vol. 39 (17), pp. e104337. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Retroelements*
Integrases/*metabolism
RNA Polymerase I/*metabolism
RNA Polymerase III/*metabolism
RNA, Transfer/*genetics
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Integrases/genetics ; RNA Polymerase I/genetics ; RNA Polymerase III/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates.
Autorzy :
Turowski TW; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK. Electronic address: .
Petfalski E; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.
Goddard BD; School of Mathematics and Maxwell Institute for Mathematical Sciences, The University of Edinburgh, Edinburgh, UK.
French SL; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Helwak A; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.
Tollervey D; Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 06; Vol. 79 (3), pp. 488-503.e11. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Elongation, Genetic*
RNA Polymerase I/*genetics
RNA Polymerase II/*genetics
RNA Polymerase III/*genetics
RNA, Fungal/*chemistry
Saccharomyces cerevisiae/*genetics
Base Composition ; Base Sequence ; Binding Sites ; Chromatin/chemistry ; Chromatin/metabolism ; DNA, Ribosomal/genetics ; DNA, Ribosomal/metabolism ; Gene Expression Regulation, Fungal ; Protein Binding ; RNA Folding ; RNA Polymerase I/metabolism ; RNA Polymerase II/metabolism ; RNA Polymerase III/metabolism ; RNA Splice Sites ; RNA Splicing ; RNA, Fungal/genetics ; RNA, Fungal/metabolism ; Saccharomyces cerevisiae/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
RNA polymerase I (Pol I) passage through nucleosomes depends on Pol I subunits binding its lobe structure.
Autorzy :
Merkl PE; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany.
Pilsl M; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany.
Fremter T; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany.
Schwank K; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany.
Engel C; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany.
Längst G; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany.
Milkereit P; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany .
Griesenbeck J; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany .
Tschochner H; Lehrstuhl Biochemie III, Universität Regensburg, Regensburg Center of Biochemistry (RCB), 93053 Regensburg, Germany .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Apr 10; Vol. 295 (15), pp. 4782-4795. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Chromatin/*metabolism
Nucleosomes/*metabolism
RNA Polymerase I/*metabolism
RNA Polymerase II/*metabolism
RNA Polymerase III/*metabolism
Saccharomyces cerevisiae/*metabolism
Chromatin/genetics ; DNA Replication ; DNA, Ribosomal/genetics ; DNA, Ribosomal/metabolism ; Nucleosomes/genetics ; Promoter Regions, Genetic ; Protein Binding ; Protein Subunits/metabolism ; RNA Polymerase I/chemistry ; RNA Polymerase I/genetics ; RNA Polymerase II/chemistry ; RNA Polymerase II/genetics ; RNA Polymerase III/chemistry ; RNA Polymerase III/genetics ; Ribosomes ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development
Czasopismo naukowe
Tytuł :
RNA Sequence and Structure Determinants of Pol III Transcriptional Termination in Human Cells.
Autorzy :
Verosloff MS; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, 2204 Tech Drive, Evanston, IL 60208, USA; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Corcoran WK; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, 2204 Tech Drive, Evanston, IL 60208, USA; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Dolberg TB; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Bushhouse DZ; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, 2204 Tech Drive, Evanston, IL 60208, USA; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Leonard JN; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. Electronic address: .
Lucks JB; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jun 25; Vol. 433 (13), pp. 166978. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcription Termination, Genetic*
RNA/*genetics
RNA/*metabolism
RNA Polymerase III/*metabolism
Base Sequence ; HEK293 Cells ; Humans ; Nucleic Acid Conformation ; Poly U/genetics ; Promoter Regions, Genetic/genetics ; RNA/chemistry
Czasopismo naukowe

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