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Wyszukujesz frazę ""RNA-Binding Protein FUS"" wg kryterium: Temat


Tytuł :
The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.
Autorzy :
Reber S; United Kingdom Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Jutzi D; United Kingdom Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Lindsay H; Department of Mathematics, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Devoy A; United Kingdom Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Mechtersheimer J; United Kingdom Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Levone BR; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Domanski M; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Bentmann E; Biomedical Center (BMC), Cell Biology, Ludwig Maximilians University Munich, Germany.
Dormann D; Biomedical Center (BMC), Cell Biology, Ludwig Maximilians University Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Mühlemann O; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Barabino SML; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Ruepp MD; United Kingdom Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7713-7731.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA-Binding Protein FUS/*metabolism
Cell Nucleus/metabolism ; Chromatin/metabolism ; Cytoplasm/metabolism ; Cytoplasmic Granules/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Protein Interaction Mapping ; RNA, Messenger/metabolism ; RNA, Small Nuclear/metabolism ; RNA-Binding Protein FUS/chemistry ; RNA-Binding Protein FUS/isolation & purification
Czasopismo naukowe
Tytuł :
Evidence of synergism among three genetic variants in a patient with LMNA-related lipodystrophy and amyotrophic lateral sclerosis leading to a remarkable nuclear phenotype.
Autorzy :
Volkening K; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Farhan SMK; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Kao J; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Leystra-Lantz C; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ang LC; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Pathology and Laboratory Medicine, London Health Sciences Centre-University Hospital, London, ON, Canada.
McIntyre A; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Wang J; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Hegele RA; Department of Pathology and Laboratory Medicine, London Health Sciences Centre-University Hospital, London, ON, Canada.; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Biochemistry, Western University, London, ON, Canada.
Strong MJ; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Jul; Vol. 476 (7), pp. 2633-2650. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/metabolism
Amyotrophic Lateral Sclerosis*/pathology
DNA Helicases*/genetics
DNA Helicases*/metabolism
Lamin Type A*/genetics
Lamin Type A*/metabolism
Lipodystrophy*/genetics
Lipodystrophy*/metabolism
Lipodystrophy*/pathology
Multifunctional Enzymes*/genetics
Multifunctional Enzymes*/metabolism
Mutation, Missense*
RNA Helicases*/genetics
RNA Helicases*/metabolism
RNA-Binding Protein FUS*/genetics
RNA-Binding Protein FUS*/metabolism
Amino Acid Substitution ; Family ; Female ; HEK293 Cells ; Humans ; Male
Czasopismo naukowe
Tytuł :
Wild-Type and Mutant FUS Expression Reduce Proliferation and Neuronal Differentiation Properties of Neural Stem Progenitor Cells.
Autorzy :
Stronati E; Center for Translational Medicine, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
Biagioni S; Dipartimento di Biologia e Biotecnologie 'Charles Darwin', Sapienza Università di Roma, 00185 Rome, Italy.
Fiore M; Istituto di Biologia e Patologia Molecolari (IBPM), Consiglio Nazionale delle Ricerche, 00185 Rome, Italy.
Giorgi M; Dipartimento di Biologia e Biotecnologie 'Charles Darwin', Sapienza Università di Roma, 00185 Rome, Italy.
Poiana G; Dipartimento di Biologia e Biotecnologie 'Charles Darwin', Sapienza Università di Roma, 00185 Rome, Italy.
Toselli C; Dipartimento di Biologia e Biotecnologie 'Charles Darwin', Sapienza Università di Roma, 00185 Rome, Italy.
Cacci E; Dipartimento di Biologia e Biotecnologie 'Charles Darwin', Sapienza Università di Roma, 00185 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 15; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Neural Stem Cells/*cytology
Neuroglia/*cytology
Neurons/*pathology
RNA-Binding Protein FUS/*metabolism
Spinal Cord/*cytology
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Cells, Cultured ; Mice ; Neural Stem Cells/metabolism ; Neural Stem Cells/pathology ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neuroglia/metabolism ; Neuroglia/pathology ; Neurons/metabolism ; RNA-Binding Protein FUS/genetics ; Spinal Cord/embryology ; Spinal Cord/metabolism ; Spinal Cord/pathology
Czasopismo naukowe
Tytuł :
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Autorzy :
Xue YC; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Ng CS; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Mohamud Y; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Fung G; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Liu H; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Bahreyni A; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Zhang J; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Luo H; Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada .; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
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Źródło :
Journal of virology [J Virol] 2021 May 24; Vol. 95 (12). Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Enterovirus B, Human/*immunology
Enterovirus B, Human/*physiology
RNA-Binding Protein FUS/*metabolism
3C Viral Proteases/metabolism ; Animals ; Antiviral Agents/pharmacology ; Autophagy ; Cell Line ; Cysteine Endopeptidases/metabolism ; Cytokines/biosynthesis ; Cytokines/genetics ; Cytoplasm/metabolism ; Cytoplasmic Granules/metabolism ; Gene Knockdown Techniques ; Gene Knockout Techniques ; Genome, Viral ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Interferon Type I/biosynthesis ; Interferon Type I/genetics ; Internal Ribosome Entry Sites ; Mice ; Motor Neurons/virology ; Poly I-C/pharmacology ; Protein Biosynthesis ; RNA, Viral/genetics ; RNA, Viral/metabolism ; RNA-Binding Protein FUS/genetics ; Stress, Physiological ; Transcription, Genetic ; Viral Proteins/biosynthesis ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS.
Autorzy :
Sahadevan S; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland.
Hembach KM; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland.; Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zürich, Switzerland.
Tantardini E; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland.
Pérez-Berlanga M; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland.
Hruska-Plochan M; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland.
Megat S; Inserm, University of Strasbourg, Strasbourg, France.
Weber J; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland.
Schwarz P; Institute of Neuropathology, University Hospital Zurich, Zürich, Switzerland.
Dupuis L; Inserm, University of Strasbourg, Strasbourg, France.
Robinson MD; Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zürich, Switzerland.
De Rossi P; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland.
Polymenidou M; Department of Quantitative Biomedicine, University of Zurich, Zürich, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 May 21; Vol. 12 (1), pp. 3027. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyotrophic Lateral Sclerosis/*metabolism
RNA/*metabolism
RNA-Binding Protein FUS/*metabolism
Synapses/*metabolism
Amyotrophic Lateral Sclerosis/pathology ; Animals ; Cell Nucleus/metabolism ; Cerebral Cortex ; Disease Models, Animal ; Mice ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/metabolism ; RNA, Messenger/metabolism ; RNA-Binding Protein FUS/genetics
SCR Disease Name :
Amyotrophic Lateral Sclerosis 2, Juvenile
Czasopismo naukowe
Tytuł :
Real-time observation of structure and dynamics during the liquid-to-solid transition of FUS LC.
Autorzy :
Berkeley RF; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California.
Kashefi M; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California.
Debelouchina GT; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Apr 06; Vol. 120 (7), pp. 1276-1287. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amyloid*/metabolism
RNA-Binding Protein FUS*/metabolism
Magnetic Resonance Spectroscopy ; Phase Transition ; Protein Domains
Czasopismo naukowe
Tytuł :
Different recognition modes of G-quadruplex RNA between two ALS/FTLD-linked proteins TDP-43 and FUS.
Autorzy :
Ishiguro A; Research Center for Micro-Nano Technology, Hosei University, Koganei, Japan.
Katayama A; Department of Molecular Analysis Laboratory, Nippon Medical School, Bunkyo-ku, Japan.
Ishihama A; Research Center for Micro-Nano Technology, Hosei University, Koganei, Japan.
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Źródło :
FEBS letters [FEBS Lett] 2021 Feb; Vol. 595 (3), pp. 310-323. Date of Electronic Publication: 2020 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G-Quadruplexes*
DNA/*chemistry
DNA-Binding Proteins/*chemistry
RNA, Messenger/*chemistry
RNA-Binding Protein FUS/*chemistry
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Base Sequence ; Binding Sites ; Cloning, Molecular ; DNA/genetics ; DNA/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Frontotemporal Lobar Degeneration/genetics ; Frontotemporal Lobar Degeneration/metabolism ; Frontotemporal Lobar Degeneration/pathology ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HEK293 Cells ; Humans ; Neurons/metabolism ; Neurons/pathology ; Nucleic Acid Conformation ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Protein FUS/genetics ; RNA-Binding Protein FUS/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Broadening the clinical spectrum of FUS mutations: a case with monomelic amyotrophy with a late progression to amyotrophic lateral sclerosis.
Autorzy :
Moglia C; ALS Center, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy. .; Struttura Complessa Neurologia IU, Azienda Ospedaliero Universitaria Città della Salute e della Scienza of Turin, via Cherasco 15, 10126, Turin, Italy. .
Calvo A; ALS Center, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Struttura Complessa Neurologia IU, Azienda Ospedaliero Universitaria Città della Salute e della Scienza of Turin, via Cherasco 15, 10126, Turin, Italy.
Brunetti M; ALS Center, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Struttura Complessa Neurologia IU, Azienda Ospedaliero Universitaria Città della Salute e della Scienza of Turin, via Cherasco 15, 10126, Turin, Italy.
Chiò A; ALS Center, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Struttura Complessa Neurologia IU, Azienda Ospedaliero Universitaria Città della Salute e della Scienza of Turin, via Cherasco 15, 10126, Turin, Italy.; Neuroscience Institute of Torino, Turin, Italy.
Grassano M; ALS Center, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
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Źródło :
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 Mar; Vol. 42 (3), pp. 1207-1209. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyotrophic Lateral Sclerosis*/complications
Amyotrophic Lateral Sclerosis*/genetics
RNA-Binding Protein FUS*/genetics
Spinal Muscular Atrophies of Childhood*
Humans ; Mutation
SCR Disease Name :
Amyotrophy, monomelic
Raport
Tytuł :
The ALS-Associated FUS (P525L) Variant Does Not Directly Interfere with Microtubule-Dependent Kinesin-1 Motility.
Autorzy :
Seifert A; Department of Neurology, Technische Universität Dresden, 01307 Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany.; B CUBE-Center for Molecular Bioengineering and Cluster of Excellence Physics of Life, Technische Universität Dresden, 01307 Dresden, Germany.
Drechsler H; B CUBE-Center for Molecular Bioengineering and Cluster of Excellence Physics of Life, Technische Universität Dresden, 01307 Dresden, Germany.
Japtok J; Department of Neurology, Technische Universität Dresden, 01307 Dresden, Germany.
Korten T; B CUBE-Center for Molecular Bioengineering and Cluster of Excellence Physics of Life, Technische Universität Dresden, 01307 Dresden, Germany.
Diez S; B CUBE-Center for Molecular Bioengineering and Cluster of Excellence Physics of Life, Technische Universität Dresden, 01307 Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Hermann A; Department of Neurology, Technische Universität Dresden, 01307 Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany.; Translational Neurodegeneration Section 'Albrecht-Kossel', Department of Neurology, University Medical Center, University of Rostock, 18147 Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, 18147 Rostock, Germany.; Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center, University of Rostock, 18147 Rostock, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 28; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Axonal Transport*
Mutation*
Amyotrophic Lateral Sclerosis/*metabolism
Microtubules/*metabolism
Motor Neurons/*metabolism
RNA-Binding Protein FUS/*genetics
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/physiopathology ; Cell Line ; Humans ; Kinesin ; Motor Neurons/physiology ; RNA-Binding Protein FUS/metabolism
SCR Disease Name :
Amyotrophic lateral sclerosis 1
Czasopismo naukowe
Tytuł :
Simulation of FUS Protein Condensates with an Adapted Coarse-Grained Model.
Autorzy :
Benayad Z; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, Germany.; Département de Chimie, École Normale Supérieure, PSL University, 75005 Paris, France.
von Bülow S; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, Germany.
Stelzl LS; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, Germany.
Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, Germany.; Institute for Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
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Źródło :
Journal of chemical theory and computation [J Chem Theory Comput] 2021 Jan 12; Vol. 17 (1), pp. 525-537. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
RNA-Binding Protein FUS/*chemistry
Molecular Dynamics Simulation ; Particle Size ; Phase Transition ; Protein Interaction Maps ; RNA-Binding Protein FUS/metabolism ; Surface Tension ; Thermodynamics ; Viscosity
Czasopismo naukowe
Tytuł :
The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity.
Autorzy :
Brunet MA; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada.; PROTEO, Quebec Network for Research on Protein Function, Structure, and Engineering, Quebec, QC, Canada.
Jacques JF; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada.; PROTEO, Quebec Network for Research on Protein Function, Structure, and Engineering, Quebec, QC, Canada.
Nassari S; Immunology and Cell Biology Department, Université de Sherbrooke, Sherbrooke, QC, Canada.
Tyzack GE; The Francis Crick Institute, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
McGoldrick P; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Zinman L; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Jean S; Immunology and Cell Biology Department, Université de Sherbrooke, Sherbrooke, QC, Canada.
Robertson J; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Patani R; The Francis Crick Institute, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Roucou X; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada.; PROTEO, Quebec Network for Research on Protein Function, Structure, and Engineering, Quebec, QC, Canada.
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Źródło :
EMBO reports [EMBO Rep] 2021 Jan 07; Vol. 22 (1), pp. e50640. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyotrophic Lateral Sclerosis*/genetics
RNA-Binding Protein FUS*/genetics
Animals ; Drosophila/genetics ; Humans ; Motor Neurons ; Mutation
Czasopismo naukowe
Tytuł :
Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS.
Autorzy :
Lee M; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0520, USA.
Ghosh U; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0520, USA.
Thurber KR; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0520, USA.
Kato M; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390-9152, USA.; Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Tycko R; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0520, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 12; Vol. 11 (1), pp. 5735. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Amyloid/*chemistry
Amyloid/*metabolism
RNA-Binding Protein FUS/*chemistry
RNA-Binding Protein FUS/*metabolism
Amyloid/genetics ; Amyloid/ultrastructure ; Cryoelectron Microscopy ; Humans ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Conformation ; Protein Domains ; Protein Interaction Domains and Motifs ; RNA-Binding Protein FUS/genetics ; RNA-Binding Protein FUS/ultrastructure ; Sequence Analysis, Protein
Czasopismo naukowe
Tytuł :
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Autorzy :
Jutzi D; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Campagne S; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland.
Schmidt R; Computational and Systems Biology, Biozentrum, University of Basel, CH-4056, Basel, Switzerland.
Reber S; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Mechtersheimer J; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Gypas F; Computational and Systems Biology, Biozentrum, University of Basel, CH-4056, Basel, Switzerland.; Friedrich Miescher Institute for Biomedical Research, CH-4058, Basel, Switzerland.
Schweingruber C; Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden.
Colombo M; Celgene Institute of Translational Research (CITRE), 41092, Seville, Spain.
von Schroetter C; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland.
Loughlin FE; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland.; Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.
Devoy A; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Hedlund E; Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden.
Zavolan M; Computational and Systems Biology, Biozentrum, University of Basel, CH-4056, Basel, Switzerland.
Allain FH; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland. .
Ruepp MD; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 11; Vol. 11 (1), pp. 6341. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyotrophic Lateral Sclerosis/*metabolism
RNA, Small Nuclear/*metabolism
RNA-Binding Protein FUS/*genetics
RNA-Binding Protein FUS/*metabolism
Ribonucleoprotein, U1 Small Nuclear/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Animals ; Cell Line ; Genetic Predisposition to Disease/genetics ; Humans ; Mice ; Mice, Knockout ; Models, Molecular ; Motor Neurons/metabolism ; Mutation ; Protein Interaction Domains and Motifs ; RNA, Small Nuclear/chemistry ; RNA-Binding Protein FUS/chemistry ; Ribonucleoprotein, U1 Small Nuclear/chemistry
Czasopismo naukowe
Tytuł :
RNA as the stone guest of protein aggregation.
Autorzy :
Louka A; UK Dementia Research Institute at the Maurice Wohl Institute of King's College London, London SE5 9RT, UK.
Zacco E; Center for Human Technologies, Central RNA laboratory, Istituto Italiano di Tecnologia, Genova 16152, Italy.
Temussi PA; UK Dementia Research Institute at the Maurice Wohl Institute of King's College London, London SE5 9RT, UK.; University 'Federico II'' Napoli, via Cynthia, Napoli 80100, Italy.
Tartaglia GG; Center for Human Technologies, Central RNA laboratory, Istituto Italiano di Tecnologia, Genova 16152, Italy.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain and ICREA, 23 Passeig Lluıs Companys, Barcelona 08010, Spain.; Charles Darwin department of Biology and Biotechnology, Sapienza University of Rome, Piazzale A. Moro 5, Rome 00185, Italy.
Pastore A; UK Dementia Research Institute at the Maurice Wohl Institute of King's College London, London SE5 9RT, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 11880-11889.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Amyotrophic Lateral Sclerosis/*genetics
DNA-Binding Proteins/*genetics
Prions/*genetics
RNA/*genetics
RNA-Binding Protein FUS/*genetics
RNA-Binding Proteins/*genetics
TATA-Binding Protein Associated Factors/*genetics
Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Binding Sites ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Gene Expression ; Humans ; Models, Molecular ; Prions/chemistry ; Prions/metabolism ; Protein Aggregates ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA/chemistry ; RNA/metabolism ; RNA-Binding Protein FUS/chemistry ; RNA-Binding Protein FUS/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism ; TATA-Binding Protein Associated Factors/chemistry ; TATA-Binding Protein Associated Factors/metabolism
Czasopismo naukowe
Tytuł :
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS.
Autorzy :
Rhine K; Program in Cell, Molecular, Developmental Biology, and Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA.
Makurath MA; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Physics, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Liu J; Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA; Medical Genetics and Ophthalmic Genomics Unit, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Skanchy S; Department of Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA.
Lopez C; Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA.
Catalan KF; Program in Cell, Molecular, Developmental Biology, and Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA.
Ma Y; Department of Biomedical Engineering, Johns Hopkins Medical Institute, 615 N Wolfe St, Baltimore, MD 21231, USA.
Fare CM; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shorter J; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ha T; Program in Cell, Molecular, Developmental Biology, and Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA; Department of Physics, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins Medical Institute, 615 N Wolfe St, Baltimore, MD 21231, USA; Howard Hughes Medical Institute, Baltimore, MD 21218, USA.
Chemla YR; Department of Physics, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Myong S; Program in Cell, Molecular, Developmental Biology, and Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA; Department of Physics, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Nov 19; Vol. 80 (4), pp. 666-681.e8. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mutation*
Amyotrophic Lateral Sclerosis/*pathology
Frontotemporal Dementia/*pathology
Glycine/*metabolism
Neuroblastoma/*pathology
RNA/*metabolism
RNA-Binding Protein FUS/*chemistry
RNA-Binding Protein FUS/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Frontotemporal Dementia/genetics ; Glycine/chemistry ; Glycine/genetics ; Humans ; Inclusion Bodies ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Protein Conformation ; RNA/chemistry ; RNA/genetics ; RNA-Binding Protein FUS/genetics ; Tumor Cells, Cultured
SCR Disease Name :
Frontotemporal Dementia With Motor Neuron Disease
Czasopismo naukowe
Tytuł :
Dissection of FUS domains involved in regulation of SnRNP70 gene expression.
Autorzy :
Nakaya T; School of Pharmacy at Fukuoka, International University of Health and Welfare, Fukuoka, Japan.
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Źródło :
FEBS letters [FEBS Lett] 2020 Nov; Vol. 594 (21), pp. 3518-3529. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Protein Domains*
RNA-Binding Protein FUS/*chemistry
RNA-Binding Protein FUS/*metabolism
Ribonucleoprotein, U1 Small Nuclear/*genetics
Animals ; Glycine/genetics ; Glycine/metabolism ; Humans ; Introns/genetics ; Mice ; Neurons/metabolism ; RNA Splicing ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Protein FUS/genetics ; Ribonucleoprotein, U1 Small Nuclear/biosynthesis ; Ribonucleoprotein, U1 Small Nuclear/metabolism
Czasopismo naukowe
Tytuł :
FUS contributes to mTOR-dependent inhibition of translation.
Autorzy :
Sévigny M; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Bourdeau Julien I; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Venkatasubramani JP; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Hui JB; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Dutchak PA; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Sephton CF; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 18459-18473. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Amyotrophic Lateral Sclerosis/*pathology
Polyribosomes/*metabolism
RNA-Binding Protein FUS/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Cytoplasm/metabolism ; HEK293 Cells ; Humans ; Inclusion Bodies ; Polyribosomes/genetics ; Protein Biosynthesis ; RNA-Binding Protein FUS/genetics ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions.
Autorzy :
Owen I; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
Rhoads S; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
Yee D; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
Wyne H; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
Gery K; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
Hannula I; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
Sundrum M; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
Shewmaker F; Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814.
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Źródło :
Molecular biology of the cell [Mol Biol Cell] 2020 Nov 01; Vol. 31 (23), pp. 2522-2536. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Phase Transition/*drug effects
Prions/*metabolism
RNA-Binding Protein FUS/*metabolism
Cell Nucleus/metabolism ; Cytoplasm/metabolism ; DNA Damage ; Humans ; Mutation ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Prions/genetics ; Protein Aggregation, Pathological ; Protein Processing, Post-Translational ; Proteomics ; RNA-Binding Protein FUS/physiology
Czasopismo naukowe
Tytuł :
LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1.
Autorzy :
Xie P; Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China.
Guo Y; Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Oct 30; Vol. 40 (10).
Typ publikacji :
Journal Article
MeSH Terms :
DNA-Binding Proteins/*metabolism
Lung Neoplasms/*metabolism
RNA, Long Noncoding/*metabolism
RNA-Binding Protein FUS/*metabolism
RNA-Binding Proteins/*metabolism
A549 Cells ; Apoptosis ; Cell Movement ; Cell Proliferation ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Neoplasm Invasiveness ; RNA Stability ; RNA, Long Noncoding/genetics ; RNA-Binding Protein FUS/genetics ; RNA-Binding Proteins/genetics ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity.
Autorzy :
Scarola M; Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie, Laboratorio Nazionale (LNCIB), Padriciano 99, 34149, Trieste, Italy.; Dipartimento di Area Medica (DAME), Università degli Studi di Udine, p.le Kolbe 4, 33100, Udine, Italy.
Comisso E; Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie, Laboratorio Nazionale (LNCIB), Padriciano 99, 34149, Trieste, Italy.; Dipartimento di Area Medica (DAME), Università degli Studi di Udine, p.le Kolbe 4, 33100, Udine, Italy.
Rosso M; Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie, Laboratorio Nazionale (LNCIB), Padriciano 99, 34149, Trieste, Italy.; Dipartimento di Science della Vita, Università degli Studi di Trieste, Via E. Weiss 2, 34127, Trieste, Italy.
Del Sal G; Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie, Laboratorio Nazionale (LNCIB), Padriciano 99, 34149, Trieste, Italy.; Dipartimento di Science della Vita, Università degli Studi di Trieste, Via E. Weiss 2, 34127, Trieste, Italy.
Schneider C; Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie, Laboratorio Nazionale (LNCIB), Padriciano 99, 34149, Trieste, Italy.; Dipartimento di Area Medica (DAME), Università degli Studi di Udine, p.le Kolbe 4, 33100, Udine, Italy.
Schoeftner S; Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie, Laboratorio Nazionale (LNCIB), Padriciano 99, 34149, Trieste, Italy. .; Dipartimento di Science della Vita, Università degli Studi di Trieste, Via E. Weiss 2, 34127, Trieste, Italy. .
Benetti R; Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie, Laboratorio Nazionale (LNCIB), Padriciano 99, 34149, Trieste, Italy. .; Dipartimento di Area Medica (DAME), Università degli Studi di Udine, p.le Kolbe 4, 33100, Udine, Italy. .
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Źródło :
Communications biology [Commun Biol] 2020 Oct 30; Vol. 3 (1), pp. 632. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Pseudogenes*
Methyltransferases/*metabolism
Octamer Transcription Factor-3/*genetics
RNA, Long Noncoding/*genetics
RNA-Binding Protein FUS/*genetics
Repressor Proteins/*metabolism
Animals ; Cell Line, Tumor ; Epigenesis, Genetic ; Female ; Gene Silencing ; Humans ; Methyltransferases/genetics ; Mice ; Multiprotein Complexes/genetics ; Ovarian Neoplasms/genetics ; Promoter Regions, Genetic ; RNA-Binding Protein FUS/metabolism ; Repressor Proteins/genetics
Czasopismo naukowe

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