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Tytuł :
Tunable Anticancer Activity of Furoylthiourea-Based Ru -Arene Complexes and Their Mechanism of Action.
Autorzy :
Swaminathan S; Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620015, Tamil Nadu, India.
Haribabu J; Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620015, Tamil Nadu, India.
Kalagatur NK; DRDO-BU Centre for Life Sciences, Bharathiar University Campus, Coimbatore, 641046, Tamil Nadu, India.
Nikhil M; Centre for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore, 560012, Karnataka, India.
Balakrishnan N; Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620015, Tamil Nadu, India.
Bhuvanesh NSP; Department of Chemistry, Texas A & M University, College station, Texas, 77842, USA.
Kadirvelu K; DRDO-BU Centre for Life Sciences, Bharathiar University Campus, Coimbatore, 641046, Tamil Nadu, India.
Kolandaivel P; Periyar University, Salem, 636011, Tamil Nadu, India.
Karvembu R; Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620015, Tamil Nadu, India.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 May 06; Vol. 27 (26), pp. 7418-7433. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/pharmacology
Coordination Complexes*/toxicity
Ruthenium*
Cell Line, Tumor ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor A
Czasopismo naukowe
Tytuł :
Influence of ruthenium doping on UV- and visible-light photoelectrocatalytic color removal from dye solutions using a TiO 2 nanotube array photoanode.
Autorzy :
García-Ramírez P; Posgrado de Doctorado en Ingeniería y Ciencias Aplicadas, Centro de Investigación en Ingeniería y Ciencias Aplicadas, Universidad Autónoma Del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca, Morelos, C.P. 62209, Mexico.
Ramírez-Morales E; División Académica de Ingeniería y Arquitectura, Universidad Juárez Autónoma de Tabasco, Av. Universidad S/N, Col. Magisterial, C.P. 86040, Villahermosa, Tabasco, Mexico.
Solis Cortazar JC; Posgrado en Ciencias en Ingeniería, Universidad Juárez Autónoma de Tabasco, Av. Universidad S/N, Col. Magisterial, C.P. 86040, Villahermosa, Tabasco, Mexico.
Sirés I; Laboratori d'Electroquímica dels Materials i del Medi Ambient, Departament de Química Física, Facultat de Química, Universitat de Barcelona, Martí I Franquès 1-11, 08028, Barcelona, Spain. Electronic address: .
Silva-Martínez S; Centro de Investigación en Ingeniería y Ciencias Aplicadas, Universidad Autónoma Del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, C.P. 62209, Cuernavaca, Morelos, Mexico. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Mar; Vol. 267, pp. 128925. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Doping in Sports*
Nanotubes*
Ruthenium*
Catalysis ; Light ; Titanium ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Heterofunctional ruthenium(II) carbosilane dendrons, a new class of dendritic molecules to fight against prostate cancer.
Autorzy :
Sanz Del Olmo N; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University of Alcalá, Madrid, Spain; Biomaterials and Nanomedicine (CIBER-BBN), Spain, Institute 'Ramón y Cajal' for Health Research (IRYCIS), Spain.
Maroto-Diaz M; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University of Alcalá, Madrid, Spain.
Quintana S; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University of Alcalá, Madrid, Spain; Biomaterials and Nanomedicine (CIBER-BBN), Spain, Institute 'Ramón y Cajal' for Health Research (IRYCIS), Spain.
Gómez R; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University of Alcalá, Madrid, Spain; Biomaterials and Nanomedicine (CIBER-BBN), Spain, Institute 'Ramón y Cajal' for Health Research (IRYCIS), Spain.
Holota M; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236, Lodz, Poland.
Ionov M; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236, Lodz, Poland.
Bryszewska M; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236, Lodz, Poland.
Carmena MJ; Department of Biology of Systems, Biochemistry and Molecular Biology Unit, University of Alcalá, Madrid, Spain.
Ortega P; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University of Alcalá, Madrid, Spain; Biomaterials and Nanomedicine (CIBER-BBN), Spain, Institute 'Ramón y Cajal' for Health Research (IRYCIS), Spain. Electronic address: .
Javier de la Mata F; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University of Alcalá, Madrid, Spain; Biomaterials and Nanomedicine (CIBER-BBN), Spain, Institute 'Ramón y Cajal' for Health Research (IRYCIS), Spain. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Dec 01; Vol. 207, pp. 112695. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Prostatic Neoplasms/*drug therapy
Ruthenium/*chemistry
Ruthenium/*pharmacology
Silanes/*chemistry
Silanes/*pharmacology
Animals ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Dendrimers/chemistry ; Dendrimers/pharmacology ; Dendrimers/therapeutic use ; HeLa Cells ; Humans ; Male ; Mice ; Mice, Nude ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Organometallic Compounds/therapeutic use ; PC-3 Cells ; Prostatic Neoplasms/pathology ; Ruthenium/therapeutic use ; Silanes/therapeutic use
Czasopismo naukowe
Tytuł :
Anticancer Ruthenium Complexes with HDAC Isoform Selectivity.
Autorzy :
Cross JM; Department of Chemistry, Durham University, Lower Mountjoy, South Road, Durham DH1 3LE, UK.
Blower TR; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
Kingdon ADH; Department of Chemistry, Durham University, Lower Mountjoy, South Road, Durham DH1 3LE, UK.
Pal R; Department of Chemistry, Durham University, Lower Mountjoy, South Road, Durham DH1 3LE, UK.
Picton DM; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
Walton JW; Department of Chemistry, Durham University, Lower Mountjoy, South Road, Durham DH1 3LE, UK.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 May 21; Vol. 25 (10). Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation/*drug effects
Histone Deacetylase Inhibitors/*pharmacology
Neoplasms/*drug therapy
Ruthenium Compounds/*pharmacology
Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; HeLa Cells ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/ultrastructure ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/genetics ; Histone Deacetylase 6/ultrastructure ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Neoplasms/genetics ; Protein Conformation/drug effects ; Protein Isoforms/genetics ; Ruthenium/chemistry ; Ruthenium/pharmacology ; Ruthenium Compounds/chemistry
Czasopismo naukowe
Tytuł :
A photoactivatable Ru (II) complex bearing 2,9-diphenyl-1,10-phenanthroline: A potent chemotherapeutic drug inducing apoptosis in triple negative human breast adenocarcinoma cells.
Autorzy :
Mansour N; Faculty of Health and Medical Sciences, Department of Microbial and Cellular Sciences, University of Surrey, UK; Department of Natural Sciences, Lebanese American University, Chouran, Beirut, 1102-2801, Lebanon.
Bodman-Smith K; Faculty of Health and Medical Sciences, Department of Microbial and Cellular Sciences, University of Surrey, UK.
Khnayzer RS; Department of Natural Sciences, Lebanese American University, Chouran, Beirut, 1102-2801, Lebanon.
Daher CF; Department of Natural Sciences, Lebanese American University, Chouran, Beirut, 1102-2801, Lebanon. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Feb 25; Vol. 336, pp. 109317. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Coordination Complexes/*pharmacology
Phenanthrolines/*pharmacology
Ruthenium/*pharmacology
Triple Negative Breast Neoplasms/*drug therapy
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Drug Screening Assays, Antitumor ; Humans ; Phenanthrolines/chemistry ; Photochemical Processes ; Ruthenium/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Bis(bipyridine)ruthenium(II) Ferrocenyl β-Diketonate Complexes: Exhibiting Nanomolar Potency against Human Cancer Cell Lines.
Autorzy :
Allison M; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
Caramés-Méndez P; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.; Department of Pharmacy, University of Huddersfield, Huddersfield, HD1 3DH, UK.
Pask CM; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
Phillips RM; Department of Pharmacy, University of Huddersfield, Huddersfield, HD1 3DH, UK.
Lord RM; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
McGowan PC; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Feb 19; Vol. 27 (11), pp. 3737-3744. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Coordination Complexes/*chemistry
Coordination Complexes/*pharmacology
Neoplasms/*drug therapy
Neoplasms/*pathology
Ruthenium/*chemistry
Cell Line, Tumor ; Comet Assay ; Humans ; Microbial Sensitivity Tests ; Ruthenium/pharmacology
Czasopismo naukowe
Tytuł :
Monitoring Contractile Cardiomyocytes via Impedance Using Multipurpose Thin Film Ruthenium Oxide Electrodes.
Autorzy :
Tanumihardja E; BIOS Lab on a Chip Group, Max Planck Centre for Complex Fluid Dynamics and Technical Medical Centre, MESA+ Institute for Nanotechnology, University of Twente, 7500 AE Enschede, The Netherlands.
de Bruijn DS; BIOS Lab on a Chip Group, Max Planck Centre for Complex Fluid Dynamics and Technical Medical Centre, MESA+ Institute for Nanotechnology, University of Twente, 7500 AE Enschede, The Netherlands.
Slaats RH; Applied Stem Cell Technologies Group, Technical Medical Centre, University of Twente, 7500 AE Enschede, The Netherlands.
Olthuis W; BIOS Lab on a Chip Group, Max Planck Centre for Complex Fluid Dynamics and Technical Medical Centre, MESA+ Institute for Nanotechnology, University of Twente, 7500 AE Enschede, The Netherlands.
van den Berg A; BIOS Lab on a Chip Group, Max Planck Centre for Complex Fluid Dynamics and Technical Medical Centre, MESA+ Institute for Nanotechnology, University of Twente, 7500 AE Enschede, The Netherlands.
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Źródło :
Sensors (Basel, Switzerland) [Sensors (Basel)] 2021 Feb 18; Vol. 21 (4). Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Electrodes*
Myocytes, Cardiac*/physiology
Oxides*
Ruthenium*
Electric Impedance ; Humans
Czasopismo naukowe
Tytuł :
Ruthenium arene complexes in the treatment of 3D models of head and neck squamous cell carcinomas.
Autorzy :
Santi M; Center for Nanotechnology , Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56126, Pisa, Italy; Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy.
Mapanao AK; Center for Nanotechnology , Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56126, Pisa, Italy; NEST-Scuola Normale Superiore, Piazza San Silvestro, 12-56126, Pisa, Italy.
Biancalana L; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.
Marchetti F; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy. Electronic address: .
Voliani V; Center for Nanotechnology , Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56126, Pisa, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 113143. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Coordination Complexes/*pharmacology
Ruthenium/*pharmacology
Squamous Cell Carcinoma of Head and Neck/*drug therapy
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Ruthenium/chemistry ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
One- and Two-Photon Phototherapeutic Effects of Ru Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumor Spheroids and Tumor-Bearing Mice*.
Autorzy :
Karges J; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.
Kuang S; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, 510275, Guangzhou, People's Republic of China.
Ong YC; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.
Chao H; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, 510275, Guangzhou, People's Republic of China.
Gasser G; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jan 04; Vol. 27 (1), pp. 362-370. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article
MeSH Terms :
Organometallic Compounds*/chemistry
Organometallic Compounds*/pharmacology
Photochemotherapy*
Photosensitizing Agents*/pharmacology
Ruthenium*/chemistry
Ruthenium*/pharmacology
Adenocarcinoma, Bronchiolo-Alveolar/drug therapy ; Adenocarcinoma, Bronchiolo-Alveolar/metabolism ; Animals ; HeLa Cells ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Mice ; Neoplasms, Basal Cell/drug therapy ; Neoplasms, Basal Cell/metabolism ; Photons/therapeutic use ; Pyridines/chemistry ; Pyridines/pharmacology ; Singlet Oxygen/metabolism ; Spheroids, Cellular ; Tumor Hypoxia ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
One-pot synthesis of sorbitol via hydrolysis-hydrogenation of cellulose in the presence of Ru-containing composites.
Autorzy :
Gromov NV; Boreskov Institute of Catalysis SB RAS, 630090, Lavrentiev Av. 5, Novosibirsk, Russia; Novosibirsk State Technical University, 630092, Karl Marx Av. 20, Novosibirsk, Russia. Electronic address: .
Medvedeva TB; Boreskov Institute of Catalysis SB RAS, 630090, Lavrentiev Av. 5, Novosibirsk, Russia.
Rodikova YA; Boreskov Institute of Catalysis SB RAS, 630090, Lavrentiev Av. 5, Novosibirsk, Russia.
Timofeeva MN; Boreskov Institute of Catalysis SB RAS, 630090, Lavrentiev Av. 5, Novosibirsk, Russia; Novosibirsk State Technical University, 630092, Karl Marx Av. 20, Novosibirsk, Russia.
Panchenko VN; Boreskov Institute of Catalysis SB RAS, 630090, Lavrentiev Av. 5, Novosibirsk, Russia; Novosibirsk State Technical University, 630092, Karl Marx Av. 20, Novosibirsk, Russia.
Taran OP; Boreskov Institute of Catalysis SB RAS, 630090, Lavrentiev Av. 5, Novosibirsk, Russia; Institute of Chemistry and Chemical Technology SB RAS, FRC Krasnoyarsk Science Center SB RAS, 660036, Akademgorodok 50/24, Krasnoyarsk, Russia.
Kozhevnikov IV; University of Liverpool, Liverpool, United Kingdom.
Parmon VN; Boreskov Institute of Catalysis SB RAS, 630090, Lavrentiev Av. 5, Novosibirsk, Russia.
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Źródło :
Bioresource technology [Bioresour Technol] 2021 Jan; Vol. 319, pp. 124122. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Ruthenium*
Sorbitol*
Catalysis ; Cellulose ; Hydrogenation ; Hydrolysis
Czasopismo naukowe
Tytuł :
Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors.
Autorzy :
Bertolini MS; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30606, USA.
Docampo R; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30606, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 07; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Channel Blockers/*pharmacology
Calcium Channels/*metabolism
Protozoan Proteins/*metabolism
Ruthenium Red/*pharmacology
Trypanosoma cruzi/*metabolism
Calcium/metabolism ; Calcium Channel Blockers/chemistry ; Calcium Channels/genetics ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/genetics ; Ruthenium Red/chemistry ; Trypanosoma cruzi/drug effects
Czasopismo naukowe
Tytuł :
Large-Scale Synthesis of a Niche Olefin Metathesis Catalyst Bearing an Unsymmetrical N-Heterocyclic Carbene (NHC) Ligand and its Application in a Green Pharmaceutical Context.
Autorzy :
Nienałtowski T; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.; Polpharma SA Pharmaceutical Works, Pelplinska 19, 83-200, Starogard Gdanski, Poland.
Szczepanik P; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
Małecki P; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
Czajkowska-Szczykowska D; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
Czarnocki S; Apeiron Synthesis SA, Duńska 9, 54-427, Wrocław, Poland.
Pawłowska J; Polpharma SA Pharmaceutical Works, Pelplinska 19, 83-200, Starogard Gdanski, Poland.
Kajetanowicz A; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
Grela K; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 01; Vol. 26 (67), pp. 15708-15717. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Organometallic Compounds*/chemistry
Ruthenium*/chemistry
Alkenes/chemistry ; Green Chemistry Technology ; Ligands ; Methane/analogs & derivatives ; Methane/chemistry
Czasopismo naukowe
Tytuł :
DNA-Targeting Ru -Polypyridyl Complex with a Long-Lived Intraligand Excited State as a Potential Photodynamic Therapy Agent.
Autorzy :
Hua W; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research and Pharmaceutical Research Center, School of Chemistry and Chemical, Engineering, Southeast University, Nanjing, 211189, P.R. China.
Xu G; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research and Pharmaceutical Research Center, School of Chemistry and Chemical, Engineering, Southeast University, Nanjing, 211189, P.R. China.
Zhao J; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research and Pharmaceutical Research Center, School of Chemistry and Chemical, Engineering, Southeast University, Nanjing, 211189, P.R. China.
Wang Z; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research and Pharmaceutical Research Center, School of Chemistry and Chemical, Engineering, Southeast University, Nanjing, 211189, P.R. China.
Lu J; Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota, 58108-6050, USA.
Sun W; Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota, 58108-6050, USA.
Gou S; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research and Pharmaceutical Research Center, School of Chemistry and Chemical, Engineering, Southeast University, Nanjing, 211189, P.R. China.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 23; Vol. 26 (72), pp. 17495-17503. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Photochemotherapy*
Ruthenium*
DNA/*chemistry
Intercalating Agents/pharmacology ; Ligands
Czasopismo naukowe
Tytuł :
Unexpected reversible and controllable nuclear uptake and efflux of the DNA "light-switching" Ru(ii)-polypyridyl complex in living cells via ion-pairing with chlorophenolate counter-anions.
Autorzy :
Huang R; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. , Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Zhu JQ; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. .
Tang M; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. .
Huang CH; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. .
Zhang ZH; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. and Department of Stomatology, Peking University Third Hospital, Beijing, 100191, China.
Sheng ZG; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. .
Liu S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. .
Zhu BZ; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, China. and Joint Institute for Environmental Science, Research Center for Eco-Environmental Sciences and Hong Kong Baptist University, Beijing, Hong Kong, China.
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2020 Dec 07; Vol. 8 (45), pp. 10327-10336. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleus/*metabolism
Coordination Complexes/*metabolism
Pyridines/*metabolism
Ruthenium/*metabolism
A549 Cells ; ATP-Binding Cassette Transporters/metabolism ; Biological Transport ; Chlorophenols/metabolism ; Coordination Complexes/analysis ; DNA/metabolism ; HeLa Cells ; Humans ; Ions/metabolism ; Pyridines/analysis ; Ruthenium/analysis
Czasopismo naukowe
Tytuł :
New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer.
Autorzy :
Wang Y; The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.; Department of Chemical Engineering, Zhejiang University, Hangzhou, 310027, P.R. China.
Jin J; Xingzhi College, Zhejiang Normal University, Jinhua, 321004, P.R. China.
Shu L; The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
Li T; The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
Lu S; Department of Laboratory Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
Subarkhan MKM; The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
Chen C; College of Life Sciences, Huzhou University, Huzhou, 313000, P.R. China.
Wang H; The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Nov 26; Vol. 26 (66), pp. 15170-15182. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/pharmacology
Organometallic Compounds*/metabolism
Ovarian Neoplasms*
Ruthenium*/pharmacology
Cisplatin/*chemistry
Animals ; Cell Line, Tumor ; Female ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II.
Autorzy :
Xiong K; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Qian C; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Yuan Y; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Wei L; College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Liao X; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
He L; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Rees TW; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Chen Y; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Wan J; College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Ji L; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Chao H; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.; College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518071, P. R. China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Sep 14; Vol. 59 (38), pp. 16631-16637. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coordination Complexes/*pharmacology
DNA Topoisomerases, Type I/*metabolism
Necroptosis/*drug effects
Poly-ADP-Ribose Binding Proteins/*antagonists & inhibitors
Ruthenium/*pharmacology
Topoisomerase Inhibitors/*pharmacology
Animals ; Biocatalysis/drug effects ; Cell Death/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; DNA Topoisomerases, Type II/metabolism ; Humans ; Mice ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Poly-ADP-Ribose Binding Proteins/metabolism ; Ruthenium/chemistry ; Topoisomerase Inhibitors/chemical synthesis ; Topoisomerase Inhibitors/chemistry
Czasopismo naukowe
Tytuł :
Ruthenium (II) complex cis-[Ru -O 2 CC 7 H 7 O 2 )(dppm) 2 ]PF 6 -hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity.
Autorzy :
Costa MS; Laboratório de Bioquímica e Toxinas Animais, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Pará avenue, 1720, Uberlândia, MG, CEP 38400-902, Brazil. .
Gonçalves YG; Instituto de Química, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
Borges BC; Laboratório de Osteoimunologia e Imunologia dos Tumores, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
Silva MJB; Laboratório de Osteoimunologia e Imunologia dos Tumores, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
Amstalden MK; Departamento de Análises Clínicas, Toxicologia e Ciências Alimentares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, CEP 14040-903, Brazil.
Costa TR; Laboratório de Bioquímica e Toxinas Animais, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Pará avenue, 1720, Uberlândia, MG, CEP 38400-902, Brazil.
Antunes LMG; Departamento de Análises Clínicas, Toxicologia e Ciências Alimentares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, CEP 14040-903, Brazil.
Rodrigues RS; Laboratório de Bioquímica e Toxinas Animais, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Pará avenue, 1720, Uberlândia, MG, CEP 38400-902, Brazil.
Rodrigues VM; Laboratório de Bioquímica e Toxinas Animais, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Pará avenue, 1720, Uberlândia, MG, CEP 38400-902, Brazil.
de Faria Franca E; Laboratório de Cristalografia e Química Computacional, Instituto de Química, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
Zoia MAP; Laboratório de Nanobiotecnologia, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
de Araújo TG; Laboratório de Nanobiotecnologia, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
Goulart LR; Laboratório de Nanobiotecnologia, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
Von Poelhsitz G; Instituto de Química, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil.
Yoneyama KAG; Laboratório de Bioquímica e Toxinas Animais, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Pará avenue, 1720, Uberlândia, MG, CEP 38400-902, Brazil. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 21; Vol. 10 (1), pp. 15410. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coordination Complexes/*pharmacology
Lung Neoplasms/*drug therapy
Ruthenium Compounds/*pharmacology
A549 Cells ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coordination Complexes/chemistry ; DNA Damage ; Humans ; Leishmania/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Membrane Potential, Mitochondrial/drug effects ; Reactive Oxygen Species/metabolism ; Ruthenium Compounds/chemistry
Czasopismo naukowe
Tytuł :
Homo- and Hetero-dinuclear Arene-Linked Osmium(II) and Ruthenium(II) Organometallics: Probing the Impact of Metal Variation on Reactivity and Biological Activity.
Autorzy :
Wilson CS; Department of Chemistry and Biochemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Prior TJ; Department of Chemistry and Biochemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Sandland J; Department of Chemistry and Biochemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Savoie H; Department of Chemistry and Biochemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Boyle RW; Department of Chemistry and Biochemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Murray BS; Department of Chemistry and Biochemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Sep 04; Vol. 26 (50), pp. 11593-11603. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/pharmacology
Organometallic Compounds*/pharmacology
Osmium*
Ruthenium*
Cell Line, Tumor ; HEK293 Cells ; HT29 Cells ; Humans ; Ligands ; Magnetic Resonance Spectroscopy ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Reduced amino acid Schiff base containing ruthenium(III) complexes: Synthesis, characterization, DNA interaction, and in vitro cytotoxicity.
Autorzy :
Zhang Z; Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Yang Z; Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Wu Y; Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Yuan Z; Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Du J; Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Li L; Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2020 Aug; Vol. 34 (8), pp. e22510. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Coordination Complexes*/chemistry
Coordination Complexes*/pharmacology
Cytotoxins*/chemistry
Cytotoxins*/pharmacology
Ruthenium*/chemistry
Ruthenium*/pharmacology
DNA/*biosynthesis
A549 Cells ; HeLa Cells ; Humans ; MCF-7 Cells ; Schiff Bases/chemistry ; Schiff Bases/pharmacology
Czasopismo naukowe
Tytuł :
Light-Triggered Trafficking to the Cell Nucleus of a Cationic Polyamidoamine Functionalized with Ruthenium Complexes.
Autorzy :
Mascheroni L; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.; Department of Nanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Francia V; Department of Nanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Rossotti B; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.; Department of Nanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Ranucci E; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.
Ferruti P; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.
Maggioni D; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.
Salvati A; Department of Nanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Aug 05; Vol. 12 (31), pp. 34576-34587. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Light*
Cell Nucleus/*drug effects
Coordination Complexes/*pharmacology
Photosensitizing Agents/*pharmacology
Polyamines/*pharmacology
Ruthenium/*pharmacology
Cations/chemistry ; Cations/pharmacology ; Cell Nucleus/metabolism ; Cell Survival/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; HeLa Cells ; Humans ; Molecular Structure ; Optical Imaging ; Photosensitizing Agents/chemical synthesis ; Photosensitizing Agents/chemistry ; Polyamines/chemistry ; Ruthenium/chemistry ; Singlet Oxygen/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe

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