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Wyświetlanie 1-15 z 15
Tytuł :
Impact of mRNA chemistry and manufacturing process on innate immune activation.
Autorzy :
Nelson J; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Sorensen EW; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Mintri S; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Rabideau AE; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Zheng W; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Besin G; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Khatwani N; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Su SV; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Miracco EJ; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Issa WJ; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Hoge S; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Stanton MG; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Joyal JL; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
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Źródło :
Science advances [Sci Adv] 2020 Jun 24; Vol. 6 (26), pp. eaaz6893. Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids.
Autorzy :
Lu Z; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Paolella BR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02139, United States.
Truex NL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Loftis AR; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Liao X; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Rabideau AE; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Brown MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02139, United States.
Busanovich J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02139, United States.
Beroukhim R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02139, United States.
Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2020 Jun 19; Vol. 15 (6), pp. 1358-1369. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antigens, Bacterial/*chemistry
Bacterial Toxins/*chemistry
Drug Carriers/*chemistry
Oligonucleotides, Antisense/*administration & dosage
Peptide Nucleic Acids/*administration & dosage
Cell Line, Tumor ; Cell Survival/drug effects ; Drug Delivery Systems ; Genetic Therapy ; Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Oligonucleotides, Antisense/pharmacology ; Peptide Nucleic Acids/pharmacology ; Phosphoproteins/genetics ; RNA Splicing Factors/genetics
Czasopismo naukowe
Tytuł :
Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase.
Autorzy :
Biancucci M; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine , Chicago, Illinois 60611, United States.
Rabideau AE; Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
Lu Z; Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
Loftis AR; Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
Satchell KJF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine , Chicago, Illinois 60611, United States.
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Źródło :
Biochemistry [Biochemistry] 2017 May 30; Vol. 56 (21), pp. 2747-2757. Date of Electronic Publication: 2017 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Toxins/*chemistry
Bacterial Toxins/*metabolism
Endopeptidases/*chemistry
Endopeptidases/*metabolism
Vibrio vulnificus/*enzymology
rap1 GTP-Binding Proteins/*metabolism
ras Proteins/*metabolism
Humans ; Models, Molecular ; Substrate Specificity ; rap1 GTP-Binding Proteins/chemistry ; ras Proteins/chemistry
Czasopismo naukowe
Tytuł :
Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin.
Autorzy :
Rabideau AE; Massachusetts Institute of Technology , Department of Chemistry, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Pentelute BL; Massachusetts Institute of Technology , Department of Chemistry, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2016 Jun 17; Vol. 11 (6), pp. 1490-501. Date of Electronic Publication: 2016 May 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Antigens, Bacterial/*chemistry
Bacterial Toxins/*chemistry
Drug Carriers/*chemistry
Proteins/*metabolism
Aminoacyltransferases/chemistry ; Animals ; Bacterial Proteins/chemistry ; Cell Line, Tumor ; Cysteine Endopeptidases/chemistry ; Cytosol/metabolism ; Humans ; Membrane Transport Proteins/metabolism ; Protein Transport ; Proteins/chemistry
Czasopismo naukowe
Tytuł :
A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway.
Autorzy :
Rabideau AE; Department of Chemistry, Massachusetts Institute of Technology , 18-596, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology , 18-596, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
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Źródło :
ACS central science [ACS Cent Sci] 2015 Nov 25; Vol. 1 (8), pp. 423-430. Date of Electronic Publication: 2015 Nov 11.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen.
Autorzy :
Rabideau AE; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18-596, Cambridge, MA 02139.
Liao X; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18-596, Cambridge, MA 02139.
Akçay G; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18-596, Cambridge, MA 02139.
Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18-596, Cambridge, MA 02139.
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Źródło :
Scientific reports [Sci Rep] 2015 Jul 16; Vol. 5, pp. 11944. Date of Electronic Publication: 2015 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antigens, Bacterial/*metabolism
Bacterial Toxins/*metabolism
Peptides/*metabolism
Amino Acid Sequence ; Cytosol/metabolism ; Peptides/chemistry ; Protein Transport
Czasopismo naukowe
Tytuł :
Delivery of mirror image polypeptides into cells.
Autorzy :
Rabideau AE; Department of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Ave. 18-596 , Cambridge , MA 02139 , USA . Email: .
Liao X; Department of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Ave. 18-596 , Cambridge , MA 02139 , USA . Email: .
Pentelute BL; Department of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Ave. 18-596 , Cambridge , MA 02139 , USA . Email: .
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Źródło :
Chemical science [Chem Sci] 2015 Jan 01; Vol. 6 (1), pp. 648-653. Date of Electronic Publication: 2014 Sep 25.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Delivery of antibody mimics into mammalian cells via anthrax toxin protective antigen.
Autorzy :
Liao X; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18-596, Cambridge, MA 02193 (USA).
Rabideau AE
Pentelute BL
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2014 Nov 03; Vol. 15 (16), pp. 2458-66. Date of Electronic Publication: 2014 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies/*metabolism
Antigens/*metabolism
Antigens, Bacterial/*chemistry
Bacterial Toxins/*chemistry
Biocompatible Materials/*chemistry
Animals ; Antibodies/chemistry ; Antigens/chemistry ; Biocompatible Materials/metabolism ; CHO Cells ; Cell-Penetrating Peptides/chemistry ; Cell-Penetrating Peptides/metabolism ; Cricetinae ; Cricetulus ; Fusion Proteins, bcr-abl/antagonists & inhibitors ; Fusion Proteins, bcr-abl/metabolism ; HEK293 Cells ; Humans ; Immunoprecipitation ; K562 Cells ; MAP Kinase Signaling System ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; raf Kinases/antagonists & inhibitors ; raf Kinases/metabolism ; ras Proteins/antagonists & inhibitors ; ras Proteins/metabolism
Czasopismo naukowe
Tytuł :
Flow-based enzymatic ligation by sortase A.
Autorzy :
Policarpo RL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).
Kang H
Liao X
Rabideau AE
Simon MD
Pentelute BL
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Aug 25; Vol. 53 (35), pp. 9203-8. Date of Electronic Publication: 2014 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Aminoacyltransferases/*metabolism
Bacterial Proteins/*metabolism
Cysteine Endopeptidases/*metabolism
Enzymes, Immobilized/*metabolism
Proteins/*chemistry
Proteins/*metabolism
Models, Molecular ; Molecular Structure
Czasopismo naukowe
Tytuł :
Protein thioester synthesis enabled by sortase.
Autorzy :
Ling JJ; Department of Chemistry, Massachusetts Institute of Technology, 16-573a, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Policarpo RL
Rabideau AE
Liao X
Pentelute BL
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2012 Jul 04; Vol. 134 (26), pp. 10749-52. Date of Electronic Publication: 2012 Jun 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Aminoacyltransferases/*metabolism
Bacterial Proteins/*metabolism
Cysteine Endopeptidases/*metabolism
Esters/*chemistry
Proteins/*chemical synthesis
Sulfhydryl Compounds/*chemistry
Antigens, Bacterial/chemistry ; Bacterial Toxins/chemistry ; Inteins ; Peptides/chemical synthesis ; Protein Transport ; Recombinant Proteins/chemistry ; Sulfur Compounds
Czasopismo naukowe
Tytuł :
A water soluble vitamin B12-ReI fluorescent conjugate for cell uptake screens: use in the confirmation of cubilin in the lung cancer line A549.
Autorzy :
Vortherms AR; Department of Chemistry, Centre for Science and Technology, Syracuse University, Syracuse, NY 13244, USA.
Kahkoska AR
Rabideau AE
Zubieta J
Andersen LL
Madsen M
Doyle RP
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2011 Sep 21; Vol. 47 (35), pp. 9792-4. Date of Electronic Publication: 2011 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms/*pathology
Receptors, Cell Surface/*genetics
Rhenium/*chemistry
Vitamin B 12/*chemistry
Vitamin B 12/*metabolism
Water/*chemistry
Biological Transport ; Cell Line, Tumor ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Solubility
Czasopismo naukowe
Tytuł :
Trifluoracetic acid-assisted crystallization of vitamin B12 results in protonation of the phosphate group of the nucleotide loop: insight into the influence of crystal packing forces on vitamin B12 structures.
Autorzy :
Marino N; Department of Chemistry, Syracuse University, Syracuse, New York 13244-4100, USA.
Rabideau AE
Doyle RP
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Źródło :
Inorganic chemistry [Inorg Chem] 2011 Jan 03; Vol. 50 (1), pp. 220-30. Date of Electronic Publication: 2010 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Conformation*
Vitamin B 12*/chemistry
Trifluoroacetic Acid/*chemistry
Cobalt/chemistry ; Corrinoids/chemistry ; Crystallization ; Crystallography, X-Ray ; Drug Delivery Systems ; Hydrogen Bonding ; Models, Molecular ; Nucleotides/chemistry ; Phosphates/chemistry ; Protons
Czasopismo naukowe
Tytuł :
Hepatoma cell uptake of cationic multifluorescent quantum dot liposomes.
Autorzy :
Bothun GD; Department of Chemical Engineering, University of Rhode Island, 205 Crawford Hall, Kingston, Rhode Island 02881, USA. />Rabideau AE
Stoner MA
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2009 Jun 04; Vol. 113 (22), pp. 7725-8.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Quantum Dots*
Cadmium Compounds/*analysis
Liposomes/*metabolism
Selenium Compounds/*analysis
Sulfides/*analysis
Zinc Compounds/*analysis
Cadmium Compounds/administration & dosage ; Carcinoma, Hepatocellular/diagnosis ; Cations/chemistry ; Cell Line, Tumor ; Cell Membrane Permeability ; Humans ; Liposomes/analysis ; Microscopy, Fluorescence ; Selenium Compounds/administration & dosage ; Sulfides/administration & dosage ; Transition Temperature ; Zinc Compounds/administration & dosage
Czasopismo naukowe
Tytuł :
Targeting the folate receptor (FR): imaging and cytotoxicity of ReI conjugates in FR-overexpressing cancer cells.
Autorzy :
Viola-Villegas N; Department of Chemistry, Syracuse University, Syracuse, NY 13244-4100, USA.
Rabideau AE
Cesnavicious J
Zubieta J
Doyle RP
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Źródło :
ChemMedChem [ChemMedChem] 2008 Sep; Vol. 3 (9), pp. 1387-94.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carrier Proteins/*biosynthesis
Carrier Proteins/*drug effects
Folic Acid/*chemistry
Organometallic Compounds/*pharmacology
Ovarian Neoplasms/*drug therapy
Receptors, Cell Surface/*biosynthesis
Receptors, Cell Surface/*drug effects
Rhenium/*chemistry
Animals ; CHO Cells ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cricetinae ; Cricetulus ; DNA/chemistry ; DNA/drug effects ; DNA Topoisomerases, Type I/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Electrophoretic Mobility Shift Assay/methods ; Female ; Folate Receptors, GPI-Anchored ; Folic Acid/analogs & derivatives ; Folic Acid/chemical synthesis ; Humans ; Inhibitory Concentration 50 ; Intercalating Agents/chemical synthesis ; Intercalating Agents/chemistry ; Intercalating Agents/pharmacology ; Microscopy, Confocal ; Molecular Structure ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Reverse Transcriptase Polymerase Chain Reaction ; Structure-Activity Relationship ; Topoisomerase I Inhibitors
Czasopismo naukowe
    Wyświetlanie 1-15 z 15

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