- Tytuł:
- Targeting the folate receptor (FR): imaging and cytotoxicity of ReI conjugates in FR-overexpressing cancer cells.
- Autorzy:
- Źródło:
- ChemMedChem [ChemMedChem] 2008 Sep; Vol. 3 (9), pp. 1387-94.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Carrier Proteins/*biosynthesis
Carrier Proteins/*drug effects
Folic Acid/*chemistry
Organometallic Compounds/*pharmacology
Ovarian Neoplasms/*drug therapy
Receptors, Cell Surface/*biosynthesis
Receptors, Cell Surface/*drug effects
Rhenium/*chemistry
Animals ; CHO Cells ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cricetinae ; Cricetulus ; DNA/chemistry ; DNA/drug effects ; DNA Topoisomerases, Type I/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Electrophoretic Mobility Shift Assay/methods ; Female ; Folate Receptors, GPI-Anchored ; Folic Acid/analogs & derivatives ; Folic Acid/chemical synthesis ; Humans ; Inhibitory Concentration 50 ; Intercalating Agents/chemical synthesis ; Intercalating Agents/chemistry ; Intercalating Agents/pharmacology ; Microscopy, Confocal ; Molecular Structure ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Reverse Transcriptase Polymerase Chain Reaction ; Structure-Activity Relationship ; Topoisomerase I Inhibitors
Czasopismo naukowe