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Wyszukujesz frazę ""Radiation-Sensitizing Agents"" wg kryterium: Temat


Tytuł :
Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas.
Autorzy :
Minea RO; Department of Neurological Surgery, Keck School of Medicine (KSOM), University of Southern California (USC), Los Angeles, California (CA), United States of America.
Duc TC; Haiphong University School of Pharmacy, Haiphong, Vietnam.
Swenson SD; Department of Neurological Surgery, Keck School of Medicine (KSOM), University of Southern California (USC), Los Angeles, California (CA), United States of America.
Cho HY; Department of Neurological Surgery, Keck School of Medicine (KSOM), University of Southern California (USC), Los Angeles, California (CA), United States of America.
Huang M; Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA, United States of America.
Hartman H; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
Hofman FM; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
Schönthal AH; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
Chen TC; Department of Neurological Surgery, Keck School of Medicine (KSOM), University of Southern California (USC), Los Angeles, California (CA), United States of America.; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0238238. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*/genetics
Dacarbazine/*analogs & derivatives
Glioma/*drug therapy
Radiation-Sensitizing Agents/*therapeutic use
Temozolomide/*therapeutic use
Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Damage/drug effects ; Dacarbazine/analysis ; Dacarbazine/metabolism ; Dacarbazine/pharmacology ; Dacarbazine/therapeutic use ; Gas Chromatography-Mass Spectrometry ; Glioma/pathology ; Humans ; Mice ; Mice, Inbred C57BL ; O(6)-Methylguanine-DNA Methyltransferase/metabolism ; Radiation-Sensitizing Agents/analysis ; Radiation-Sensitizing Agents/metabolism ; Radiation-Sensitizing Agents/pharmacology ; Temozolomide/analysis ; Temozolomide/metabolism ; Temozolomide/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro .
Autorzy :
Petrovic M; Clinical Center of Kragujevac, Kragujevac, Serbia.
Popovic S; Department of Immunology and Microbiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Baskic D; Department of Immunology and Microbiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Todorovic M; Department of Forensic Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Djurdjevic P; Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Ristic-Fira A; Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Keta O; Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Petkovic V; Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Koricanac L; Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Stojkovic D; Institute for Information Technologies, University of Kragujevac, Kragujevac, Serbia.
Jevtic V; Faculty of Science, University of Kragujevac, Kragujevac, Serbia.
Trifunovic S; Faculty of Science, University of Kragujevac, Kragujevac, Serbia.
Todorovic D; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia .
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Źródło :
Anticancer research [Anticancer Res] 2020 Sep; Vol. 40 (9), pp. 5001-5013.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Organoplatinum Compounds/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Cisplatin/pharmacology ; Dose-Response Relationship, Drug ; Edetic Acid/analogs & derivatives ; Edetic Acid/chemistry ; Gamma Rays ; Humans ; Inhibitory Concentration 50 ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Radiation-Sensitizing Agents/chemical synthesis ; Radiation-Sensitizing Agents/chemistry
Czasopismo naukowe
Tytuł :
Increased local tumor control through nanoparticle-mediated, radiation-triggered release of nitrite, an important precursor for reactive nitrogen species.
Autorzy :
Kim AS; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States of America.
Melemenidis S
Gustavsson AK
Abid D
Wu Y
Liu F
Hristov D
Schüler E
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Źródło :
Physics in medicine and biology [Phys Med Biol] 2020 Sep 25; Vol. 65 (19), pp. 195003. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gamma Rays*
Breast Neoplasms/*therapy
Gold/*chemistry
Metal Nanoparticles/*administration & dosage
Nitrites/*metabolism
Radiation-Sensitizing Agents/*administration & dosage
Reactive Nitrogen Species/*metabolism
Animals ; Apoptosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Combined Modality Therapy ; Female ; Humans ; Metal Nanoparticles/chemistry ; Mice ; Mice, Nude ; Radiation-Sensitizing Agents/chemistry ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.
Autorzy :
Hatami E; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Jaggi M; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.
Chauhan SC; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.
Yallapu MM; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2020 Aug; Vol. 1874 (1), pp. 188381. Date of Electronic Publication: 2020 May 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents, Phytogenic/*administration & dosage
Nanomedicine/*methods
Neoplasms/*therapy
Radiation-Sensitizing Agents/*administration & dosage
Xanthones/*administration & dosage
Animals ; Antineoplastic Agents, Phytogenic/economics ; Chemoradiotherapy/economics ; Chemoradiotherapy/methods ; Clinical Trials, Phase II as Topic ; Dose-Response Relationship, Drug ; Drug Carriers/chemistry ; Drug Costs ; Garcinia/chemistry ; Humans ; Nanomedicine/economics ; Nanoparticles/chemistry ; Neoplasms/economics ; Radiation-Sensitizing Agents/economics ; Resins, Plant/chemistry ; Treatment Outcome ; Xanthones/economics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Analysis of photoreactivity and phototoxicity of riboflavin's analogue 3MeTARF.
Autorzy :
Wolnicka-Glubisz A; Department of Biophysics Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland. Electronic address: .
Pawlak A; Department of Biophysics Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Insinska-Rak M; Faculty of Chemistry, Adam Mickiewicz University in Poznan, Uniwersytetu Poznanskiego 8, 61-614 Poznań, Poland.
Zadlo A; Department of Biophysics Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2020 Apr; Vol. 205, pp. 111820. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Radiation-Sensitizing Agents*/chemistry
Radiation-Sensitizing Agents*/radiation effects
Radiation-Sensitizing Agents*/toxicity
Riboflavin*/analogs & derivatives
Riboflavin*/chemistry
Riboflavin*/radiation effects
Riboflavin*/toxicity
Cell Line, Tumor ; Cell Survival/drug effects ; Dermatitis, Phototoxic ; Humans ; Hydrogen Peroxide/metabolism ; Light ; Singlet Oxygen/chemistry
Czasopismo naukowe
Tytuł :
BiO 2- x Nanosheets as Radiosensitizers with Catalase-Like Activity for Hypoxia Alleviation and Enhancement of the Radiotherapy of Tumors.
Autorzy :
Liu H; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Cheng R; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Dong X; Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Zhu S; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Zhou R; Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Yan L; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Zhang C; Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Wang Q; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China.
Gu Z; Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100049, China.
Zhao Y; Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100190, China.
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Źródło :
Inorganic chemistry [Inorg Chem] 2020 Mar 16; Vol. 59 (6), pp. 3482-3493. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Bismuth/*therapeutic use
Nanostructures/*therapeutic use
Neoplasms/*drug therapy
Radiation-Sensitizing Agents/*therapeutic use
Tumor Hypoxia/*drug effects
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/radiation effects ; Bismuth/chemistry ; Catalase/chemistry ; Cell Line, Tumor ; DNA/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrogen Peroxide/metabolism ; Mice, Inbred BALB C ; Nanostructures/chemistry ; Nanostructures/radiation effects ; Oxygen/metabolism ; Radiation-Sensitizing Agents/chemical synthesis ; Radiation-Sensitizing Agents/radiation effects ; X-Rays ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy.
Autorzy :
Dong C; Department of Ultrasound, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. , No. 180 Fenglin Road, Shanghai, 200032, China.
Jiang Q; State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. .
Qian X; Department of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212002, China.
Wu W; State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. .
Wang W; Department of Ultrasound, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. , No. 180 Fenglin Road, Shanghai, 200032, China.
Yu L; State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. .
Chen Y; State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. .
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Źródło :
Nanoscale [Nanoscale] 2020 Mar 05; Vol. 12 (9), pp. 5587-5600.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*chemistry
Nanoparticles/*chemistry
Paclitaxel/*chemistry
Porphyrins/*chemistry
Radiation-Sensitizing Agents/*chemistry
Theranostic Nanomedicine/*methods
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Endocytosis ; Female ; Fluorescent Dyes/chemistry ; Humans ; Mice ; Mice, Inbred BALB C ; Nanoparticles/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Porphyrins/pharmacology ; Porphyrins/therapeutic use ; Radiation-Sensitizing Agents/pharmacology ; Radiation-Sensitizing Agents/therapeutic use ; Singlet Oxygen/metabolism ; Tissue Distribution ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Doxorubicin-loaded pH-responsive nanoparticles coated with chlorin e6 for drug delivery and synergetic chemo-photodynamic therapy.
Autorzy :
Liang J; Department of Polymer Materials, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
Jin X
Chen B
Hu J
Huang Q
Wan J
Hu Z
Wang B
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Źródło :
Nanotechnology [Nanotechnology] 2020 May 08; Vol. 31 (19), pp. 195103. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*pharmacology
Doxorubicin/*pharmacology
Porphyrins/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Antibiotics, Antineoplastic/chemistry ; Capsules ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Doxorubicin/chemistry ; Drug Synergism ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Nanoparticles ; Particle Size ; Photochemotherapy ; Photosensitizing Agents ; Porphyrins/chemistry ; Radiation-Sensitizing Agents/chemistry ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Development of Novel Radiosensitizers through the National Cancer Institute's Small Business Innovation Research Program.
Autorzy :
Zakeri K; Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Narayanan D; Department of Small Business Innovation Research (SBIR) Development Center, National Cancer Institute, Bethesda, Maryland.
Prasanna PGS; Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland.
Vikram B; Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland.
Buchsbaum JC; Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland.
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Źródło :
Radiation research [Radiat Res] 2020 May; Vol. 193 (5), pp. 425-434. Date of Electronic Publication: 2020 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
National Cancer Institute (U.S.)*
Radiation-Sensitizing Agents*
Research*
Small Business*
Drug Discovery/*methods
United States
Czasopismo naukowe
Tytuł :
The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo.
Autorzy :
Paillas S; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom.
Then CK; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom.
Kilgas S; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom.
Ruan JL; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom.
Thompson J; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom.
Elliott A; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom.
Smart S; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom.
Kiltie AE; Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom. Electronic address: .
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Źródło :
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2020 May 01; Vol. 107 (1), pp. 212-221. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depsipeptides/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Urinary Bladder Neoplasms/*pathology
Acetylation/drug effects ; Acetylation/radiation effects ; Cell Line, Tumor ; DNA Breaks, Double-Stranded/drug effects ; DNA Breaks, Double-Stranded/radiation effects ; DNA Repair/drug effects ; DNA Repair/radiation effects ; Depsipeptides/adverse effects ; Histone Deacetylase Inhibitors/adverse effects ; Histones/metabolism ; Humans ; Organs at Risk/radiation effects ; Radiation-Sensitizing Agents/adverse effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Enhancement radiation-induced apoptosis in C6 glioma tumor-bearing rats via pH-responsive magnetic graphene oxide nanocarrier.
Autorzy :
Shirvalilou S; Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Khoei S; Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: .
Khoee S; Department of Polymer Chemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Mahdavi SR; Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Raoufi NJ; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Motevalian M; Razi Drug Research Centre, Iran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Karimi MY; Razi Drug Research Centre, Iran University of Medical Sciences, Tehran, Iran.
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2020 Apr; Vol. 205, pp. 111827. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Neoplasms/*drug therapy
Glioma/*drug therapy
Graphite/*administration & dosage
Idoxuridine/*administration & dosage
Nanoparticles/*administration & dosage
Polylactic Acid-Polyglycolic Acid Copolymer/*administration & dosage
Radiation-Sensitizing Agents/*administration & dosage
Animals ; Brain/metabolism ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Drug Liberation ; Glioma/metabolism ; Glioma/pathology ; Graphite/chemistry ; Graphite/pharmacokinetics ; Hydrogen-Ion Concentration ; Idoxuridine/pharmacokinetics ; Magnetic Phenomena ; Male ; Nanoparticles/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/pharmacokinetics ; Rabbits ; Radiation-Sensitizing Agents/pharmacokinetics ; Rats, Wistar ; Tumor Burden/drug effects
Czasopismo naukowe
Tytuł :
Uptake and excretion dynamics of gold nanoparticles in cancer cells and fibroblasts.
Autorzy :
Ivošev V; ISMO (UMR 8214), University Paris-Saclay, University Paris Sud, CNRS, F-91405 Orsay Cedex, France.
Sánchez GJ
Stefancikova L
Haidar DA
González Vargas CR
Yang X
Bazzi R
Porcel E
Roux S
Lacombe S
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Źródło :
Nanotechnology [Nanotechnology] 2020 Mar 27; Vol. 31 (13), pp. 135102. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
Fibroblasts/*cytology
Gold/*pharmacokinetics
Radiation-Sensitizing Agents/*pharmacokinetics
Cell Line, Tumor ; Cell Proliferation/drug effects ; Fibroblasts/chemistry ; Gold/chemistry ; HeLa Cells ; Humans ; Metal Nanoparticles/chemistry ; PC-3 Cells ; Pentetic Acid/chemistry ; Radiation-Sensitizing Agents/chemistry
Czasopismo naukowe
Tytuł :
Overcoming Radioresistance in Tumor Therapy by Alleviating Hypoxia and Using the HIF-1 Inhibitor.
Autorzy :
Zhou X; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
Liu H; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
Zheng Y; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
Han Y; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
Wang T; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
Zhang H; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
Sun Q; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
Li Z; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , P. R. China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Jan 29; Vol. 12 (4), pp. 4231-4240. Date of Electronic Publication: 2020 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
Acriflavine*/chemistry
Acriflavine*/pharmacology
Hypoxia-Inducible Factor 1, alpha Subunit*/antagonists & inhibitors
Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism
Metal Nanoparticles*/chemistry
Metal Nanoparticles*/therapeutic use
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Neoplasms*/metabolism
Neoplasms*/pathology
Neoplasms*/radiotherapy
Radiation-Sensitizing Agents*/chemistry
Radiation-Sensitizing Agents*/pharmacology
Radiation Tolerance/*drug effects
3T3 Cells ; Animals ; Cell Hypoxia/drug effects ; Cell Line, Tumor ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; X-Ray Therapy
Czasopismo naukowe
Tytuł :
Poly(vinyl alcohol) boosting therapeutic potential of p -boronophenylalanine in neutron capture therapy by modulating metabolism.
Autorzy :
Nomoto T; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Inoue Y; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Yao Y; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Suzuki M; Division of Particle Radiation Oncology, Particle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
Kanamori K; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Takemoto H; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Matsui M; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Tomoda K; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Nishiyama N; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.; Innovation Center of Nanomedicine, Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan.
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Źródło :
Science advances [Sci Adv] 2020 Jan 22; Vol. 6 (4), pp. eaaz1722. Date of Electronic Publication: 2020 Jan 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Boron Neutron Capture Therapy*
Boron Compounds/*pharmacology
Energy Metabolism/*drug effects
Phenylalanine/*analogs & derivatives
Polyvinyl Alcohol/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Animals ; Boron Compounds/chemistry ; Boron Compounds/pharmacokinetics ; Cell Line, Tumor ; Disease Models, Animal ; Drug Synergism ; Humans ; Mass Spectrometry ; Mice ; Neoplasms/therapy ; Phenylalanine/chemistry ; Phenylalanine/pharmacokinetics ; Phenylalanine/pharmacology ; Polyvinyl Alcohol/chemistry ; Polyvinyl Alcohol/pharmacokinetics ; Radiation-Sensitizing Agents/chemistry ; Radiation-Sensitizing Agents/pharmacokinetics ; Signal Transduction/drug effects ; Tissue Distribution ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Dual pH-triggered catalytic selective Mn clusters for cancer radiosensitization and radioprotection.
Autorzy :
Lv S; The Affiliated Da Yi Hospital of Shanxi Medical University; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China. .
Long W
Chen J
Ren Q
Wang J
Mu X
Liu H
Zhang XD
Zhang R
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Źródło :
Nanoscale [Nanoscale] 2020 Jan 02; Vol. 12 (2), pp. 548-557.
Typ publikacji :
Journal Article
MeSH Terms :
Manganese*
Neoplasms/*radiotherapy
Radiation-Protective Agents/*therapeutic use
Radiation-Sensitizing Agents/*therapeutic use
Animals ; CHO Cells ; Catalysis ; Cell Line, Tumor ; Cell Survival/radiation effects ; Cricetulus ; Hydrogen-Ion Concentration ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; Oxidation-Reduction ; Radiation-Protective Agents/chemical synthesis ; Radiation-Protective Agents/chemistry ; Radiation-Sensitizing Agents/chemical synthesis ; Radiation-Sensitizing Agents/chemistry ; Reactive Oxygen Species/metabolism ; Treatment Outcome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
RGD-functionalized magnetosomes are efficient tumor radioenhancers for X-rays and protons.
Autorzy :
Hafsi M; Laboratoire TIRO, UMRE 4320, BIAM, DRT, CEA, Nice Côte d'Azur University, France.
Preveral S; Laboratoire de Bioénergétique Cellulaire, Institute of Biosciences and Biotechnologies of Aix Marseille (BIAM), Saint-Paul-lez-Durance, France.
Hoog C; Department of Radiology, Centre Antoine Lacassagne, Nice Côte d'Azur University, France; Federation Claude Lalanne, Nice Côte d'Azur University, France.
Hérault J; Department of Radiation Therapy, Proton Therapy Center, Centre Antoine Lacassagne, Nice Côte d'Azur University, France; Federation Claude Lalanne, Nice Côte d'Azur University, France.
Perrier GA; Laboratoire de Bioénergétique Cellulaire, Institute of Biosciences and Biotechnologies of Aix Marseille (BIAM), Saint-Paul-lez-Durance, France.
Lefèvre CT; Laboratoire de Bioénergétique Cellulaire, Institute of Biosciences and Biotechnologies of Aix Marseille (BIAM), Saint-Paul-lez-Durance, France.
Michel H; Institut de Chimie de Nice, UMR7272, Nice Côte d'Azur University, France.
Pignol D; Laboratoire de Bioénergétique Cellulaire, Institute of Biosciences and Biotechnologies of Aix Marseille (BIAM), Saint-Paul-lez-Durance, France.
Doyen J; Department of Radiation Therapy, Proton Therapy Center, Centre Antoine Lacassagne, Nice Côte d'Azur University, France; Federation Claude Lalanne, Nice Côte d'Azur University, France.
Pourcher T; Laboratoire TIRO, UMRE 4320, BIAM, DRT, CEA, Nice Côte d'Azur University, France; Federation Claude Lalanne, Nice Côte d'Azur University, France.
Humbert O; Laboratoire TIRO, UMRE 4320, BIAM, DRT, CEA, Nice Côte d'Azur University, France; Department of Nuclear Medicine, Centre Antoine Lacassagne, Nice Côte d'Azur University, France.
Thariat J; Department of Radiology, Centre Antoine Lacassagne, Nice Côte d'Azur University, France; Department of Radiation Therapy, Proton Therapy Center, Centre Antoine Lacassagne, Nice Côte d'Azur University, France; Department of Radiation Oncology, Centre François Baclesse, Université de Normandie, France.
Cambien B; Laboratoire TIRO, UMRE 4320, BIAM, DRT, CEA, Nice Côte d'Azur University, France; Federation Claude Lalanne, Nice Côte d'Azur University, France. Electronic address: .
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Źródło :
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2020 Jan; Vol. 23, pp. 102084. Date of Electronic Publication: 2019 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oligopeptides*/chemistry
Oligopeptides*/pharmacology
Radiation-Sensitizing Agents*/chemistry
Radiation-Sensitizing Agents*/pharmacology
Magnetosomes/*chemistry
Magnetospirillum/*chemistry
Neoplasms, Experimental/*radiotherapy
Animals ; Cell Line, Tumor ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Proton Therapy ; X-Ray Therapy
SCR Organism :
Magnetospirillum magneticum
Czasopismo naukowe
Tytuł :
Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications.
Autorzy :
Boateng F; TIDTAC LLC, Orlando, FL 32828, USA.
Ngwa W; TIDTAC LLC, Orlando, FL 32828, USA.; Department of Physics and Applied Physics, University of Massachusetts Lowell Lowell, MA 01854, USA.; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Radiation Oncology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 31; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chemoradiotherapy*
Drug Delivery Systems*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Radiation-Sensitizing Agents*/chemistry
Radiation-Sensitizing Agents*/therapeutic use
Lung Neoplasms/*therapy
Animals ; Humans
Czasopismo naukowe
Tytuł :
A bioactivatable self-quenched nanogel for targeted photodynamic therapy.
Autorzy :
He H; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. .
Nieminen AL; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, 70 President Street, MSC 140, Charleston, SC 29425, USA.
Xu P; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. .
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Źródło :
Biomaterials science [Biomater Sci] 2019 Dec 01; Vol. 7 (12), pp. 5143-5149. Date of Electronic Publication: 2019 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Chlorophyll/*analogs & derivatives
Head and Neck Neoplasms/*therapy
Radiation-Sensitizing Agents/*administration & dosage
Squamous Cell Carcinoma of Head and Neck/*therapy
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chlorophyll/administration & dosage ; Chlorophyll/chemistry ; Chlorophyll/therapeutic use ; ErbB Receptors/antagonists & inhibitors ; HeLa Cells ; Head and Neck Neoplasms/metabolism ; Humans ; Ligands ; Mice ; Molecular Targeted Therapy ; Nanogels/chemistry ; Photochemotherapy ; Radiation-Sensitizing Agents/chemistry ; Radiation-Sensitizing Agents/therapeutic use ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Novel sulphonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers.
Autorzy :
Soliman AM; a Department of Drug Radiation Research , National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA) , Nasr City , Egypt.
Alqahtani AS; b Department of Medicinal , Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University , Riyadh , Saudi Arabia.; c Department of Pharmacognosy , College of Pharmacy, King Saud University , Riyadh , Saudi Arabia.
Ghorab M; a Department of Drug Radiation Research , National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA) , Nasr City , Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 1030-1040.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Quinazolinones/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Receptor, ErbB-2/*antagonists & inhibitors
Sulfonamides/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinazolinones/chemical synthesis ; Quinazolinones/chemistry ; Radiation-Sensitizing Agents/chemical synthesis ; Radiation-Sensitizing Agents/chemistry ; Receptor, ErbB-2/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy.
Autorzy :
Zong Z; a Nanjing Medical University , Nanjing , China.; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.; c Department of Neurosurgery , Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.
Hua L; a Nanjing Medical University , Nanjing , China.; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.; c Department of Neurosurgery , Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.
Wang Z; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.
Xu H; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.
Ye C; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.
Pan B; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.
Zhao Z; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.
Zhang L; d Department of Radiation Oncology , Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.
Lu J; e Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life Science , Jiangsu Normal University , Xuzhou , China.
Mei LH; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.; c Department of Neurosurgery , Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.; f Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy , Cancer Institute, Xuzhou Medical University , Xuzhou , China.
Rutong Y; a Nanjing Medical University , Nanjing , China.; b Institute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , China.; c Department of Neurosurgery , Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.; f Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy , Cancer Institute, Xuzhou Medical University , Xuzhou , China.
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Źródło :
Drug delivery [Drug Deliv] 2019 Dec; Vol. 26 (1), pp. 34-44.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Alkylating/*administration & dosage
Glioma/*therapy
Nanoparticles/*administration & dosage
Peptides/*administration & dosage
Radiation-Sensitizing Agents/*administration & dosage
Temozolomide/*administration & dosage
Animals ; Antineoplastic Agents, Alkylating/chemical synthesis ; Antineoplastic Agents, Alkylating/metabolism ; Cell Line, Tumor ; Combined Modality Therapy/methods ; Drug Delivery Systems/methods ; Glioma/metabolism ; Humans ; Male ; Mice ; Mice, Inbred ICR ; Mice, Nude ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Peptides/chemical synthesis ; Peptides/metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage ; Polylactic Acid-Polyglycolic Acid Copolymer/chemical synthesis ; Polylactic Acid-Polyglycolic Acid Copolymer/metabolism ; Prodrugs/administration & dosage ; Prodrugs/chemistry ; Prodrugs/metabolism ; Radiation-Sensitizing Agents/chemical synthesis ; Radiation-Sensitizing Agents/metabolism ; Radiotherapy/methods ; Temozolomide/chemical synthesis ; Temozolomide/metabolism ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe

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