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Wyświetlanie 1-17 z 17
Tytuł :
R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.
Autorzy :
Conboy CB; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Vélez-Reyes GL; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Abrahante JE; University of Minnesota Informatics Institute, Minneapolis, Minnesota, USA.
Temiz NA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Burns MB; Biochemistry, Molecular Biology and Biophysics Department, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Harris RS; Biochemistry, Molecular Biology and Biophysics Department, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Starr TK; Department of Obstetrics, Gynecology and Women's Health and University of Minnesota, Minneapolis, Minnesota, USA.
Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Jan; Vol. 40 (1), pp. 70-79. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*genetics
Breast Neoplasms/*genetics
Colonic Neoplasms/*genetics
Intercellular Signaling Peptides and Proteins/*genetics
Thrombospondins/*genetics
Adenocarcinoma/metabolism ; Breast Neoplasms/metabolism ; Cell Line ; Colonic Neoplasms/metabolism ; Female ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; MCF-7 Cells ; Male ; Receptors, G-Protein-Coupled/metabolism ; Thrombospondins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Up-Regulation ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma.
Autorzy :
Smeester BA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Draper GM; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Slipek NJ; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Larsson AT; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Stratton N; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Pomeroy EJ; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Becklin KL; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Yamamoto K; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Williams KB; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Laoharawee K; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Peterson JJ; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Abrahante JE; UMII, University of Minnesota, Minneapolis, Minnesota.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Mills LJ; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Crosby MR; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Hudson WA; AHCSH Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Rahrmann EP; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, England.
Largaespada DA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Moriarity BS; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota. .
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2020 Dec; Vol. 19 (12), pp. 2528-2541. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.
Autorzy :
Smeester BA; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Slipek NJ; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Pomeroy EJ; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Laoharawee K; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Osum SH; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Larsson AT; Masonic Cancer Center, University of Minnesota, United States of America.
Williams KB; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Stratton N; Department of Pediatrics, University of Minnesota, United States of America.
Yamamoto K; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America.
Peterson JJ; Department of Pediatrics, University of Minnesota, United States of America.
Rathe SK; Department of Pediatrics, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Mills LJ; Department of Pediatrics, University of Minnesota, United States of America; Childhood Cancer Genomics Group, University of Minnesota, United States of America.
Hudson WA; Department of Pediatrics, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Crosby MR; Department of Pediatrics, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Wang M; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America.
Rahrmann EP; Cancer Research UK Cambridge Institute, University of Cambridge, United Kingdom of Great Britain and Northern Ireland.
Moriarity BS; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America. Electronic address: .
Largaespada DA; Department of Pediatrics, University of Minnesota, United States of America; Department of Genetics, Cell Biology and Development, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America. Electronic address: .
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Źródło :
Bone [Bone] 2020 Jul; Vol. 136, pp. 115353. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy.
Autorzy :
Xiong Z; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Ampudia Mesias E; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Pluhar GE; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Largaespada DA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Sham YY; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, Minnesota.
Moertel CL; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Olin MR; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota. .; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Jan 01; Vol. 26 (1), pp. 232-241. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*metabolism
Dendritic Cells/*immunology
Glioblastoma/*drug therapy
Immunotherapy/*methods
Orexin Receptors/*metabolism
Peptide Fragments/*pharmacology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; Antigens, CD/chemistry ; Cells, Cultured ; Glioblastoma/immunology ; Glioblastoma/metabolism ; Humans ; Immune Tolerance ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Orexin Receptors/chemistry ; Peptide Fragments/chemical synthesis ; Programmed Cell Death 1 Receptor/immunology
Czasopismo naukowe
Tytuł :
Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Autorzy :
Rahrmann EP; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota. .; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Wolf NK; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.
Otto GM; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Heltemes-Harris L; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Lab Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, Division of Hematopathology, University of Minnesota, Minneapolis, Minnesota.
Ramsey LB; Department of Laboratory Medicine and Pathology, Division of Hematopathology, University of Minnesota, Minneapolis, Minnesota.
Shu J; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
LaRue RS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Linden MA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Starr TK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Ob-Gyn and Women's Health, University of Minnesota, Minneapolis, Minnesota.
Farrar MA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Lab Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, Division of Hematopathology, University of Minnesota, Minneapolis, Minnesota.
Moriarity BS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Largaespada DA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
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Źródło :
Molecular cancer research : MCR [Mol Cancer Res] 2019 Feb; Vol. 17 (2), pp. 567-582. Date of Electronic Publication: 2018 Oct 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*genetics
Lymphoma, Large B-Cell, Diffuse/*genetics
Transcription Factors/*genetics
Animals ; Cell Line, Tumor ; Humans ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; MAP Kinase Signaling System ; Mice ; Mice, Transgenic ; Mutagenesis, Insertional ; Mutation
Czasopismo naukowe
Tytuł :
Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas.
Autorzy :
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA. .
Popescu FE; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Johnson JE; Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
Watson AL; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Marko TA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Moriarity BS; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Ohlfest JR; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
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Źródło :
Scientific reports [Sci Rep] 2019 Jan 23; Vol. 9 (1), pp. 358. Date of Electronic Publication: 2019 Jan 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm/*genetics
Antigens, Neoplasm/*immunology
Bone Neoplasms/*genetics
Bone Neoplasms/*immunology
Oncogene Proteins, Fusion/*genetics
Oncogene Proteins, Fusion/*immunology
Osteosarcoma/*genetics
Osteosarcoma/*immunology
Animals ; Antiporters/genetics ; Bone Neoplasms/pathology ; CD8-Positive T-Lymphocytes/metabolism ; CLOCK Proteins/genetics ; Cation Transport Proteins/genetics ; Cell Line, Tumor ; Computational Biology/methods ; Epitopes/genetics ; Epitopes/immunology ; Gene Expression Profiling ; Genetic Loci ; Genomic Instability ; High-Throughput Nucleotide Sequencing ; Mice ; Open Reading Frames ; Osteosarcoma/pathology ; Transcription, Genetic ; Transcriptome
Czasopismo naukowe
Tytuł :
Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.
Autorzy :
Scott MC; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Animal Cancer Care and Research Program, University of Minnesota, St. Paul, Minnesota.; Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota.
Temiz NA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota.
Sarver AE; Department of Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota.
LaRue RS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Varshney J; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Wolf NK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Genetics, Cell Biology and Development, University of Minnesota School of Medicine, Minneapolis, Minnesota.
Moriarity BS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Brain Tumor Program, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.; Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota.
O'Brien TD; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Animal Cancer Care and Research Program, University of Minnesota, St. Paul, Minnesota.; Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota.; Stem Cell Institute University of Minnesota, Minneapolis, Minnesota.
Spector LG; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota.
Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Department of Genetics, Cell Biology and Development, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Brain Tumor Program, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Modiano JF; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Animal Cancer Care and Research Program, University of Minnesota, St. Paul, Minnesota.; Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota.; Stem Cell Institute University of Minnesota, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota.
Subramanian S; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota.
Sarver AL; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. .; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota.
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Źródło :
Cancer research [Cancer Res] 2018 Jan 15; Vol. 78 (2), pp. 326-337. Date of Electronic Publication: 2017 Oct 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Transcriptome*
Biomarkers, Tumor/*genetics
Bone Neoplasms/*mortality
Immunity, Cellular/*genetics
Osteosarcoma/*mortality
Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/secondary ; Case-Control Studies ; Dogs ; Gene Expression Profiling ; Humans ; Mice ; Neoplasm Metastasis ; Osteosarcoma/genetics ; Osteosarcoma/secondary ; Prognosis ; Survival Rate
Czasopismo naukowe
Tytuł :
Transcriptomic analysis of gene signatures associated with sickle pain.
Autorzy :
Paul JA; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Aich A; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Abrahante JE; University of Minnesota Informatics Institute, Minneapolis, Minnesota 55455, USA.
Wang Y; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
LaRue RS; Minnesota Super Computing Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Kalland K; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Mittal A; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Jha R; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Peng F; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.; Department of Pediatrics, Division of Hematology, Oncology and Transplantations, University of Minnesota, Minneapolis, Minnesota 55455, USA.; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Bagchi A; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA.; Department of Urology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Gupta K; Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
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Źródło :
Scientific data [Sci Data] 2017 May 16; Vol. 4, pp. 170051. Date of Electronic Publication: 2017 May 16.
Typ publikacji :
Dataset; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ganglia, Spinal*
Gene Expression Profiling*
Anemia, Sickle Cell/*physiopathology
Pain/*genetics
Anemia, Sickle Cell/genetics ; Animals ; Humans ; Mice ; Mice, Transgenic ; RNA/genetics
Czasopismo naukowe
Tytuł :
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.
Autorzy :
Marko TA; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.
Shamsan GA; Department of Biomedical Engineering University of Minnesota, Minneapolis, MN, USA.
Edwards EN; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.
Hazelton PE; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.
Rathe SK; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.
Cornax I; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.; Comparative Pathology Shared Resource, University of Minnesota, Minneapolis, MN, USA.
Overn PR; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.; Comparative Pathology Shared Resource, University of Minnesota, Minneapolis, MN, USA.
Varshney J; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.
Diessner BJ; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Moriarity BS; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
O'Sullivan MG; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.; Comparative Pathology Shared Resource, University of Minnesota, Minneapolis, MN, USA.; College of Veterinary Medicine, Department of Veterinary Population Medicine, University of Minnesota, Minneapolis, MN, USA.
Odde DJ; Department of Biomedical Engineering University of Minnesota, Minneapolis, MN, USA.
Largaespada DA; University of Minnesota, Masonic Cancer Center Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
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Źródło :
Scientific reports [Sci Rep] 2016 Dec 14; Vol. 6, pp. 39059. Date of Electronic Publication: 2016 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Tumor Suppressor*
Bone Neoplasms/*metabolism
GTPase-Activating Proteins/*genetics
GTPase-Activating Proteins/*metabolism
Osteosarcoma/*metabolism
Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Knockout Techniques ; Genetic Testing ; Humans ; Mice ; Neoplasm Grading ; Neoplasm Metastasis ; Osteosarcoma/genetics ; Osteosarcoma/pathology ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML.
Autorzy :
Kurata M; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Bailey NJ; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Aumann NK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Jones JM; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Veldhuijzen GW; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Moriarity BS; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.; Brain Tumor Program, University of Minnesota, Minneapolis, MN, USA.
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Źródło :
Scientific reports [Sci Rep] 2016 Nov 03; Vol. 6, pp. 36199. Date of Electronic Publication: 2016 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Library*
Genetic Testing*
Genome, Human*
Clustered Regularly Interspaced Short Palindromic Repeats/*genetics
Cytarabine/*therapeutic use
Drug Resistance, Neoplasm/*genetics
Leukemia, Myeloid, Acute/*drug therapy
Animals ; Base Sequence ; Cell Line ; Clone Cells ; Cytarabine/pharmacology ; DNA, Complementary/genetics ; Deoxycytidine Kinase/genetics ; Dexamethasone/pharmacology ; Equilibrative Nucleoside Transporter 1/genetics ; Genetic Loci ; Glucocorticoids/pharmacology ; Humans ; Inhibitory Concentration 50 ; Leukemia, Myeloid, Acute/enzymology ; Leukemia, Myeloid, Acute/genetics ; Mice ; Mutation/genetics ; Prednisolone/pharmacology ; RNA, Guide/genetics ; Receptors, Glucocorticoid/metabolism ; Reproducibility of Results ; U937 Cells
Czasopismo naukowe
Tytuł :
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
Autorzy :
Kempema AM; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Widen JC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Hexum JK; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Andrews TE; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Wang D; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Meece FA; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Noble KE; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Sachs Z; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Harki DA; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Aug 01; Vol. 23 (15), pp. 4737-4745. Date of Electronic Publication: 2015 May 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Sesquiterpenes/*chemistry
Alkenes/chemistry ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Crystallography, X-Ray ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/mortality ; Mice ; Molecular Conformation ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Reactive Oxygen Species/metabolism ; Sesquiterpenes/chemical synthesis ; Sesquiterpenes/pharmacology
Czasopismo naukowe
Tytuł :
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.
Autorzy :
Moriarity BS; 1] Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA. [2] Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA. [3] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Otto GM; 1] Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA. [2] Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA. [3] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [4] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Rahrmann EP; 1] Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA. [2] Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA. [3] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [4] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Wolf NK; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [2] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Weg MT; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [2] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Manlove LA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
LaRue RS; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [2] Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Temiz NA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Molyneux SD; Ontario Cancer Institute, Toronto, Ontario, Canada.
Choi K; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Holly KJ; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Sarver AL; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Scott MC; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [2] Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA.
Forster CL; BioNet, Academic Health Center, University of Minnesota, Minneapolis, Minnesota, USA.
Modiano JF; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [2] Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA. [3] Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Khanna C; Tumor and Metastasis Biology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Hewitt SM; Tissue Array Research Program (TARP), Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.
Khokha R; Ontario Cancer Institute, Toronto, Ontario, Canada.
Yang Y; Department of Orthopedic Surgery, Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing, China.
Gorlick R; 1] Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, New York, USA. [2] Department of Molecular Pharmacology, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, New York, USA.
Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Largaespada DA; 1] Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA. [2] Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA. [3] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [4] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
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Źródło :
Nature genetics [Nat Genet] 2015 Jun; Vol. 47 (6), pp. 615-24. Date of Electronic Publication: 2015 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*genetics
Osteosarcoma/*genetics
Animals ; Bone Neoplasms/pathology ; Carcinogenesis/genetics ; Cell Line, Tumor ; DNA Transposable Elements ; Dogs ; Genetic Predisposition to Disease ; Genomic Instability ; Humans ; Mice, Transgenic ; Mutagenesis, Insertional ; Osteosarcoma/secondary ; PTEN Phosphohydrolase/genetics ; Semaphorins/genetics ; Semaphorins/metabolism ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.
Autorzy :
Sachs Z; Division of Hematology, Oncology, and Transplantation, Department of Medicine.
LaRue RS; Division of Hematology, Oncology, and Transplantation, Department of Medicine, Department of Genetics, Cell Biology and Development, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN;
Nguyen HT; Division of Hematology, Oncology, and Transplantation, Department of Medicine.
Sachs K; Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, CA;
Noble KE; Division of Hematology, Oncology, and Transplantation, Department of Medicine.
Mohd Hassan NA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN;
Diaz-Flores E; Department of Pediatrics and Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, CA;
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN;
Sarver AL; Masonic Cancer Center, University of Minnesota, Minneapolis, MN;
Bendall SC; Department of Pathology, Stanford School of Medicine, Stanford, CA; and.
Ha NA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN;
Diers MD; Department of Genetics, Cell Biology and Development, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN;
Nolan GP; Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, CA;
Shannon KM; Department of Pediatrics and Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, CA;
Largaespada DA; Department of Genetics, Cell Biology and Development, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN; Center for Genome Engineering and Department of Pediatrics, University of Minnesota, Minneapolis, MN.
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Źródło :
Blood [Blood] 2014 Nov 20; Vol. 124 (22), pp. 3274-83. Date of Electronic Publication: 2014 Oct 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation/*genetics
GTP Phosphohydrolases/*physiology
Leukemia, Myeloid, Acute/*genetics
Leukemia, Myeloid, Acute/*pathology
Membrane Proteins/*physiology
Amino Acid Substitution ; Animals ; Cell Transformation, Neoplastic/genetics ; Disease Models, Animal ; GTP Phosphohydrolases/genetics ; Gene Expression Regulation, Leukemic ; Glycine/genetics ; Humans ; Membrane Proteins/genetics ; Mice ; Mice, SCID ; Oncogenes/physiology ; Transcriptome ; Tumor Cells, Cultured ; Valine/genetics
Czasopismo naukowe
Tytuł :
Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia.
Autorzy :
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Moriarity BS; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA [2] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA [3] Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
Stoltenberg CB; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Kurata M; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Aumann NK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Rahrmann EP; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA [2] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA [3] Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
Bailey NJ; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Melrose EG; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Beckmann DA; 1] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA [2] Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
Liska CR; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Largaespada DA; 1] Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA [2] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA [3] Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA [4] Brain Tumor Program, University of Minnesota, Minneapolis, MN, USA [5] Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
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Źródło :
Scientific reports [Sci Rep] 2014 Aug 13; Vol. 4, pp. 6048. Date of Electronic Publication: 2014 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytarabine/*pharmacology
Drug Resistance, Neoplasm/*genetics
Leukemia, Myeloid, Acute/*drug therapy
Leukemia, Myeloid, Acute/*genetics
Protein-Serine-Threonine Kinases/*genetics
3T3 Cells ; Animals ; Antimetabolites, Antineoplastic/pharmacology ; Base Sequence ; Cell Line, Tumor ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; High-Throughput Nucleotide Sequencing ; Mice ; RNA Interference ; RNA, Small Interfering ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
MMuFLR: missense mutation and frameshift location reporter.
Autorzy :
Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. />Johnson JE
Silverstein KA
Erdmann JJ
Watson AL
Popescu FE
Ohlfest JR
Largaespada DA
Pokaż więcej
Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2013 Sep 15; Vol. 29 (18), pp. 2353-4. Date of Electronic Publication: 2013 Jul 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Frameshift Mutation*
Mutation, Missense*
Software*
High-Throughput Nucleotide Sequencing ; Humans ; Neoplasm Proteins/genetics ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Deoxycytidine kinase is downregulated in Ara-C-resistant acute myeloid leukemia murine cell lines.
Autorzy :
Rathe SK
Largaespada DA
Pokaż więcej
Źródło :
Leukemia [Leukemia] 2010 Aug; Vol. 24 (8), pp. 1513-5. Date of Electronic Publication: 2010 May 27.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Antimetabolites, Antineoplastic/*pharmacology
Cytarabine/*pharmacology
Deoxycytidine Kinase/*metabolism
Leukemia, Myeloid, Acute/*enzymology
Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Leukemia, Myeloid, Acute/pathology ; Mice
Raport
Tytuł :
A microarray study of altered gene expression after cytarabine resistance in acute myeloid leukemia.
Autorzy :
Yin B
Tsai ML
Hasz DE
Rathe SK
Le Beau MM
Largaespada DA
Pokaż więcej
Źródło :
Leukemia [Leukemia] 2007 May; Vol. 21 (5), pp. 1093-7. Date of Electronic Publication: 2007 Feb 15.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Retracted Publication
MeSH Terms :
Gene Expression Profiling*
Antimetabolites, Antineoplastic/*therapeutic use
Cytarabine/*therapeutic use
Leukemia, Myeloid, Acute/*drug therapy
Leukemia, Myeloid, Acute/*genetics
Oligonucleotide Array Sequence Analysis/*methods
Amyloid beta-Protein Precursor/genetics ; DNA Mismatch Repair ; Drug Resistance, Neoplasm ; Humans ; Proto-Oncogene Proteins c-bcl-2/genetics
Raport
    Wyświetlanie 1-17 z 17

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