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Wyszukujesz frazę ""Rats, Inbred SHR"" wg kryterium: Temat


Tytuł :
Involvement of sex hormones, oxidative stress, ACE and ACE2 activity in the impairment of renal function and remodelling in SHR.
Autorzy :
Melo Junior AF; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Dalpiaz PLM; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Escouto LDS; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Sousa GJ; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Aires R; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Oliveira ND; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Carmona AK; Department of Biophysics, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
Gava ÁL; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Bissoli NS; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118138. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*/physiology
Gonadal Steroid Hormones/*metabolism
Kidney Diseases/*etiology
Peptidyl-Dipeptidase A/*metabolism
Rats, Inbred SHR/*metabolism
Angiotensin-Converting Enzyme 2 ; Animals ; Blotting, Western ; Collagen/metabolism ; Female ; Kidney/enzymology ; Kidney/metabolism ; Kidney/pathology ; Kidney/physiopathology ; Kidney Diseases/pathology ; Kidney Diseases/physiopathology ; Male ; Orchiectomy ; Ovariectomy ; Rats ; Rats, Inbred SHR/physiology ; Reactive Oxygen Species/metabolism ; Sex Factors
Czasopismo naukowe
Tytuł :
CIHH protects the heart against left ventricular remodelling and myocardial fibrosis by balancing the renin-angiotensin system in SHR.
Autorzy :
Yu B; Department of Physiology, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei Province 050017, China; Department of Emergency, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei Province 050011, China.
Chen H; Department of Coronary Care Unit, The Hebei General Hospital, Shijiazhuang, No.348, HepingWest Road, Hebei Province 050051, China.
Guo XQ; Department of Physiology, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei Province 050017, China.
Hua H; Department of Physiology, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei Province 050017, China.
Guan Y; Department of Physiology, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei Province 050017, China.
Cui F; Department of Electron Microscope Laboratory Centre, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang 050017, China.
Tian YM; Department of Physiology, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei Province 050017, China.
Zhang HX; Core Facilities and Centers, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang 050017, China.
Zhang XJ; Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang 050000, China.
Zhang Y; Department of Physiology, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei Province 050017, China; Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang 050000, China. Electronic address: .
Ma HJ; Department of Physiology, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei Province 050017, China; Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang 050000, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119540. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article
MeSH Terms :
Renin-Angiotensin System*
Ventricular Remodeling*
Altitude Sickness/*epidemiology
Hypertension/*epidemiology
Hypertension/*pathology
Myocardium/*pathology
Altitude ; Animals ; Fibrosis ; Hypertension/metabolism ; Male ; Myocardium/metabolism ; Oxygen/metabolism ; Protective Factors ; Rats, Inbred SHR ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.
Autorzy :
Cil O; Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA. Electronic address: .
Chen X; Department of Medicine, University of California, San Francisco, San Francisco, California, USA; Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
Askew Page HR; Vascular Biology Research Centre, Institute of Molecular and Clinical Sciences, St. George's University of London, London, UK.
Baldwin SN; Vascular Biology Research Centre, Institute of Molecular and Clinical Sciences, St. George's University of London, London, UK.
Jordan MC; Department of Physiology, University of California, Los Angeles, Los Angeles, California, USA.
Myat Thwe P; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California, USA.
Anderson MO; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California, USA.
Haggie PM; Department of Medicine, University of California, San Francisco, San Francisco, California, USA; Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
Greenwood IA; Vascular Biology Research Centre, Institute of Molecular and Clinical Sciences, St. George's University of London, London, UK.
Roos KP; Department of Physiology, University of California, Los Angeles, Los Angeles, California, USA.
Verkman AS; Department of Medicine, University of California, San Francisco, San Francisco, California, USA; Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
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Źródło :
Kidney international [Kidney Int] 2021 Aug; Vol. 100 (2), pp. 311-320. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypertension*/drug therapy
Vasoconstriction*
Animals ; Blood Pressure ; Chloride Channels ; Mice ; Muscle, Smooth, Vascular ; Rats ; Rats, Inbred SHR
Czasopismo naukowe
Tytuł :
Effects of a β2-adrenergic receptor blocker on experimental periodontitis in spontaneously hypertensive rats.
Autorzy :
Takeguchi A; Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8651, Japan.
Miyazawa K; Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8651, Japan.
Sato T; Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8651, Japan. Electronic address: .
Tabuchi M; Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8651, Japan.
Muramatsu R; Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8651, Japan.
Maeda H; Department of Oral Pathology, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8650, Japan.
Togari A; Department of Pharmacology, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8650, Japan.
Goto S; Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi 464-8651, Japan.
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Źródło :
Life sciences [Life Sci] 2021 Jul 15; Vol. 277, pp. 119593. Date of Electronic Publication: 2021 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Butoxamine/*pharmacology
Periodontitis/*drug therapy
Receptors, Adrenergic, beta-2/*metabolism
Adrenergic beta-2 Receptor Antagonists/pharmacology ; Alveolar Bone Loss/metabolism ; Animals ; Blood Pressure/drug effects ; Bone Density/drug effects ; Bone and Bones/drug effects ; Butoxamine/metabolism ; Female ; Hypertension/metabolism ; Male ; Osteoclasts/drug effects ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptors, Adrenergic/metabolism ; Sympathetic Nervous System/drug effects ; X-Ray Microtomography/methods
Czasopismo naukowe
Tytuł :
Role of chymase in blood pressure control, plasma and tissue angiotensin II, renal Haemodynamics, and excretion in spontaneously hypertensive rats.
Autorzy :
Roszkowska-Chojecka MM; Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Baranowska I; Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Gawrys O; Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Sadowski J; Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Walkowska A; Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Kalisz M; Department of Clinical Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Litwiniuk A; Department of Clinical Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Kompanowska-Jezierska E; Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
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Źródło :
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2021 Jul 04; Vol. 43 (5), pp. 392-401. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Hemodynamics*/drug effects
Angiotensin II/*blood
Blood Pressure/*physiology
Chymases/*metabolism
Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Blood Pressure/drug effects ; Chymases/antagonists & inhibitors ; Glomerular Filtration Rate/drug effects ; Hypertension/physiopathology ; Ilium/blood supply ; Ilium/drug effects ; Kidney/blood supply ; Kidney/drug effects ; Kidney/physiopathology ; Male ; Oligopeptides ; Perfusion ; Potassium/metabolism ; Rats, Inbred SHR ; Rats, Inbred WKY ; Regional Blood Flow/drug effects ; Sodium/metabolism
Czasopismo naukowe
Tytuł :
Cardioprotective effects of transplanted adipose-derived stem cells under Ang II stress with Danggui administration augments cardiac function through upregulation of insulin-like growth factor 1 receptor in late-stage hypertension rats.
Autorzy :
Barik P; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Shibu MA; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Hsieh DJ; School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.
Day CH; Department of Nursing, Mei Ho University, Pingtung, Taiwan.
Chen RJ; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Kuo WW; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Chang YM; The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan.
Padma VV; Department of Biotechnology, Bharathiar University, Coimbatore, India.
Ho TJ; Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan.
Huang CY; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Jul; Vol. 36 (7), pp. 1466-1475. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension*
Insulin-Like Growth Factor I*
Animals ; Rats ; Rats, Inbred SHR ; Stem Cells ; Up-Regulation
Czasopismo naukowe
Tytuł :
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
Autorzy :
Jiang J; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Ding FX; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Zhou X; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Bateman TJ; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Dong S; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Gu X; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Keh deJesus R; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Pio B; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Tang H; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Chobanian HR; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Levorse D; Discovery and Preclinical Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Hu M; Discovery and Preclinical Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Thomas-Fowlkes B; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Margulis M; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Koehler M; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Weinglass A; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Gibson J; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Houle K; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Yudkovitz J; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Hampton C; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Pai LY; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Samuel K; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Cutarelli T; Discovery Process Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Sullivan K; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Parmee ER; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Davies I; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Pasternak A; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7691-7701. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Natriuretic Agents/*chemistry
Potassium Channel Blockers/*chemistry
Potassium Channels, Inwardly Rectifying/*antagonists & inhibitors
Action Potentials/drug effects ; Animals ; Benzofurans/chemistry ; Blood Pressure/drug effects ; Diuretics/chemistry ; Diuretics/metabolism ; Diuretics/pharmacology ; Dogs ; Half-Life ; Haplorhini ; Humans ; Male ; Natriuretic Agents/metabolism ; Natriuretic Agents/pharmacology ; Piperazines/chemistry ; Potassium/urine ; Potassium Channel Blockers/metabolism ; Potassium Channel Blockers/pharmacology ; Potassium Channels, Inwardly Rectifying/metabolism ; Rats ; Rats, Inbred SHR
Czasopismo naukowe
Tytuł :
Time-of-Day-Dependent Effects of Bromocriptine to Ameliorate Vascular Pathology and Metabolic Syndrome in SHR Rats Held on High Fat Diet.
Autorzy :
Ezrokhi M; VeroScience LLC, Tiverton, RI 02878, USA.
Zhang Y; VeroScience LLC, Tiverton, RI 02878, USA.
Luo S; VeroScience LLC, Tiverton, RI 02878, USA.
Cincotta AH; VeroScience LLC, Tiverton, RI 02878, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 07; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Circadian Rhythm*
Bromocriptine/*pharmacology
Cardiovascular Diseases/*drug therapy
Diet, High-Fat/*adverse effects
Hormone Antagonists/*pharmacology
Hypertension/*complications
Metabolic Syndrome/*drug therapy
Animals ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/pathology ; Insulin Resistance ; Male ; Metabolic Syndrome/etiology ; Metabolic Syndrome/pathology ; Rats ; Rats, Inbred SHR ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Targeted Metabolic Profiling and PRM Analysis of Proteins Revealed Impaired Polyunsaturated Fatty Acid Metabolism and GTP Metabolism in the Brainstem of Spontaneously Hypertensive Rats.
Autorzy :
Zhou W; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; Shanghai Zhulian Intelligent Technology Ltd. Co., Shanghai 201323, China.
Zhu B; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Kou F; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Qi S; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Lv C; Shanghai Zhulian Intelligent Technology Ltd. Co., Shanghai 201323, China.
Cheng Y; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Wei H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
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Źródło :
Journal of proteome research [J Proteome Res] 2021 Jun 04; Vol. 20 (6), pp. 3305-3314. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension*
Animals ; Brain Stem ; Fatty Acids, Unsaturated ; Guanosine Triphosphate ; Rats ; Rats, Inbred SHR ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
Autorzy :
Liu S; The Second Clinical College, Dalian Medical University, Dalian, P.R. China.; Health Management Center, First Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.
Wang C; Health Management Center, First Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.
Lu J; Department of Ophthalmology, First Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.
Dai G; Clinical Research Center, He Eye Specialists Hospitals, Shenyang, P.R. China.
Che H; Clinical Research Center, He Eye Specialists Hospitals, Shenyang, P.R. China.
He W; The Second Clinical College, Dalian Medical University, Dalian, P.R. China.; Clinical Research Center, He Eye Specialists Hospitals, Shenyang, P.R. China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2021 Jun; Vol. 49 (6), pp. 3000605211020641.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension*/drug therapy
Retinal Diseases*/drug therapy
Retinal Diseases*/genetics
Animals ; Blood Pressure ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reactive Oxygen Species ; Ubiquitin Thiolesterase/genetics
Czasopismo naukowe
Tytuł :
A single episode of stress during adolescence impairs short-term memory and increases risk behaviour in an animal model of attention-deficit/hyperactivity disorder.
Autorzy :
Raony Í; Laboratory of Neurobiology of Animal Behaviour, Department of Neurobiology, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil. Electronic address: .
Geraldo A; Laboratory of Neurobiology of Animal Behaviour, Department of Neurobiology, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil. Electronic address: .
Pandolfo P; Laboratory of Neurobiology of Animal Behaviour, Department of Neurobiology, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil. Electronic address: .
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Źródło :
Behavioural processes [Behav Processes] 2021 Jun; Vol. 187, pp. 104395. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Attention Deficit Disorder with Hyperactivity*
Adolescent ; Animals ; Disease Models, Animal ; Humans ; Memory, Short-Term ; Rats ; Rats, Inbred SHR ; Risk-Taking
Czasopismo naukowe
Tytuł :
Identification, Characterization and Antihypertensive Effect In Vivo of a Novel ACE-Inhibitory Heptapeptide from Defatted Areca Nut Kernel Globulin Hydrolysates.
Autorzy :
Liu X; College of Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030619, China.
Li G; College of Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030619, China.
Wang H; College of Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030619, China.
Qin N; College of Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030619, China.
Guo L; College of Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030619, China.
Wang X; College of Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030619, China.
Shen S; Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 31; Vol. 26 (11). Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme Inhibitors/*chemistry
Areca/*metabolism
Globulins/*pharmacology
Amino Acid Sequence/genetics ; Animals ; Antihypertensive Agents/chemistry ; Blood Pressure/drug effects ; Globulins/metabolism ; Hypertension/metabolism ; Male ; Molecular Docking Simulation/methods ; Nuts/metabolism ; Peptide Fragments/pharmacology ; Peptides/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Protein Hydrolysates/chemistry ; Protein Hydrolysates/metabolism ; Rats ; Rats, Inbred SHR ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats.
Autorzy :
Cao P; Department of Cardiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University.; Department of Geriatrics, Taian City Central Hospital.
Zhang W; Department of Geriatrics, Taian City Central Hospital.
Wang G; Department of Geriatrics, Taian City Central Hospital.
Zhao X; Department of Cardiology, People's Hospital of Dongying.
Gao N; Department of Cardiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University.
Liu Z; Department of Geriatrics, Taian City Central Hospital.
Xu R; Department of Cardiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University.; Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University.
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Źródło :
International heart journal [Int Heart J] 2021 May 29; Vol. 62 (3), pp. 627-635. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Folic Acid/*therapeutic use
Heart Diseases/*prevention & control
Hematinics/*therapeutic use
Hyperhomocysteinemia/*complications
Hypertension/*complications
Animals ; Diastole ; Drug Evaluation, Preclinical ; Fibrosis ; Heart/physiopathology ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Male ; Myocardium/pathology ; Random Allocation ; Rats, Inbred SHR
Czasopismo naukowe
Tytuł :
Contrasting Roles of Ang II and ACEA in the Regulation of IL10 and IL1β Gene Expression in Primary SHR Astroglial Cultures.
Autorzy :
Haspula D; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
Clark MA; Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 19; Vol. 26 (10). Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II/*pharmacology
Arachidonic Acids/*pharmacology
Gene Expression/*drug effects
Interleukin-10/*genetics
Interleukin-18/*genetics
Animals ; Astrocytes/drug effects ; Cerebellum/cytology ; Cerebellum/drug effects ; Cerebellum/metabolism ; Male ; RNA, Messenger/genetics ; Rats ; Rats, Inbred SHR ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Soluble guanylate cyclase chronic stimulation effects on cardiovascular reactivity in cafeteria diet-induced rat model of metabolic syndrome.
Autorzy :
Doghri Y; UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France.
Dubreil L; UMR PAnTher 703 INRA/Oniris Animal Pathophysiology and Bio Therapy for Muscle and Nervous System Diseases, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France.
Lalanne V; UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France.
Hélissen O; UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France.
Fleurisson R; UMR PAnTher 703 INRA/Oniris Animal Pathophysiology and Bio Therapy for Muscle and Nervous System Diseases, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France.
Thorin C; UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France.
Desfontis JC; UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France.
Mallem MY; UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, Nantes-Atlantic College of Veterinary Medicine Food Sciences and Engineering, 44307, Nantes Cedex 03, France. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 May 15; Vol. 899, pp. 173978. Date of Electronic Publication: 2021 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiovascular Diseases/*prevention & control
Enzyme Activators/*pharmacology
Metabolic Syndrome/*prevention & control
Pyrazoles/*pharmacology
Pyridines/*pharmacology
Soluble Guanylyl Cyclase/*metabolism
Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/enzymology ; Aorta, Thoracic/physiopathology ; Cardiovascular Diseases/enzymology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Coronary Circulation/drug effects ; Cyclic GMP/metabolism ; Disease Models, Animal ; Enzyme Activation ; Glucose Intolerance/enzymology ; Glucose Intolerance/etiology ; Glucose Intolerance/physiopathology ; Glucose Intolerance/prevention & control ; Hypertension/enzymology ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertension/prevention & control ; Hypertriglyceridemia/enzymology ; Hypertriglyceridemia/etiology ; Hypertriglyceridemia/physiopathology ; Hypertriglyceridemia/prevention & control ; Isolated Heart Preparation ; Male ; Metabolic Syndrome/enzymology ; Metabolic Syndrome/etiology ; Metabolic Syndrome/physiopathology ; Nitric Oxide Synthase Type II/metabolism ; Obesity, Abdominal/enzymology ; Obesity, Abdominal/etiology ; Obesity, Abdominal/physiopathology ; Obesity, Abdominal/prevention & control ; Rats, Inbred SHR ; Vasoconstriction/drug effects ; Vasodilation/drug effects ; Ventricular Function, Left/drug effects ; Ventricular Pressure/drug effects
Czasopismo naukowe
Tytuł :
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042).
Autorzy :
Hahn MG; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Lampe T; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
El Sheikh S; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Griebenow N; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Woltering E; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Schlemmer KH; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Dietz L; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Gerisch M; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Wunder F; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Becker-Pelster EM; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Mondritzki T; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.; University of Witten/Herdecke, 58455 Witten, Germany.
Tinel H; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Knorr A; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Kern A; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Lang D; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Hueser J; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Schomber T; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Benardeau A; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Eitner F; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.; Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany.
Truebel H; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.; University of Witten/Herdecke, 58455 Witten, Germany.
Mittendorf J; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Kumar V; Department of Biochemistry, Case Western Reserve University, 44106 Cleveland, Ohio, United States.
van den Akker F; Department of Biochemistry, Case Western Reserve University, 44106 Cleveland, Ohio, United States.
Schaefer M; Lead Discovery-Structural Biology, Nuvisan ICB GmbH, 13353 Berlin, Germany.
Geiss V; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Sandner P; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.; Institute of Pharmacology, Hannover Medical School, 30625 Hannover, Germany.
Stasch JP; Research and Development, Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.; Institute of Pharmacy, University Halle-Wittenberg, 06120 Halle, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5323-5344. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Enzyme Activators/*chemistry
Soluble Guanylyl Cyclase/*chemistry
Animals ; Binding Sites ; Crystallography, X-Ray ; Cytochrome P-450 CYP3A/chemistry ; Cytochrome P-450 CYP3A/metabolism ; Dogs ; Enzyme Activators/metabolism ; Enzyme Activators/pharmacology ; Enzyme Activators/therapeutic use ; Half-Life ; Heart Rate/drug effects ; Hemodynamics/drug effects ; Hypertension/drug therapy ; Hypertension/pathology ; Molecular Dynamics Simulation ; Rats ; Rats, Inbred SHR ; Solubility ; Soluble Guanylyl Cyclase/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties.
Autorzy :
Grujić-Milanović J; Laboratory for Experimental Hypertension, Institute for Medical Research, Department for Cardiovascular Research, University of Belgrade, National Institute of the Republic Serbia, 11000 Belgrade, Serbia.
Jaćević V; Department for Experimental Toxicology and Pharmacology, National Poison Control Centre, Military Medical Academy, 11000 Belgrade, Serbia.; Medical Faculty of the Military Medical Academy, University of Defence, 11000 Belgrade, Serbia.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 500 30 Hradec Kralove, Czech Republic.
Miloradović Z; Laboratory for Experimental Hypertension, Institute for Medical Research, Department for Cardiovascular Research, University of Belgrade, National Institute of the Republic Serbia, 11000 Belgrade, Serbia.
Jovović D; Laboratory for Experimental Hypertension, Institute for Medical Research, Department for Cardiovascular Research, University of Belgrade, National Institute of the Republic Serbia, 11000 Belgrade, Serbia.
Milosavljević I; Institute of Pathology and Forensic Medicine, Military Medical Academy, 11000 Belgrade, Serbia.
Milanović SD; Institute for Medical Research, Department for Biomedical Engineering and Biophysics, University of Belgrade, National Institute of the Republic Serbia, 11000 Belgrade, Serbia.
Mihailović-Stanojević N; Laboratory for Experimental Hypertension, Institute for Medical Research, Department for Cardiovascular Research, University of Belgrade, National Institute of the Republic Serbia, 11000 Belgrade, Serbia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 08; Vol. 22 (9). Date of Electronic Publication: 2021 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Anti-Inflammatory Agents/*therapeutic use
Antioxidants/*therapeutic use
Cardiotonic Agents/*therapeutic use
Hypertension, Malignant/*drug therapy
Resveratrol/*therapeutic use
Animals ; Anti-Inflammatory Agents/pharmacology ; Body Weight/drug effects ; Cardiotonic Agents/pharmacology ; Female ; Heart Ventricles/drug effects ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Hemodynamics/drug effects ; Hypertension, Malignant/enzymology ; Hypertension, Malignant/pathology ; Hypertension, Malignant/physiopathology ; Inflammation/complications ; Inflammation/drug therapy ; Myocardium/pathology ; NG-Nitroarginine Methyl Ester/chemistry ; NG-Nitroarginine Methyl Ester/pharmacology ; Organ Size/drug effects ; Oxidation-Reduction ; Rats, Inbred SHR ; Resveratrol/chemistry ; Resveratrol/pharmacology ; Thiobarbituric Acid Reactive Substances/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597.
Autorzy :
Baranowska-Kuczko M; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.; Department of Clinical Pharmacy, Medical University of Białystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.
Kozłowska H; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.
Kloza M; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.
Harasim-Symbor E; Department of Physiology, Medical University of Białystok, ul. Mickiewicza 2C, 15-222 Białystok, Poland.
Biernacki M; Department of Analytical Chemistry, Medical University of Białystok, ul. Mickiewicza 2D, 15-222 Białystok, Poland.
Kasacka I; Department of Histology and Cytophysiology, Medical University of Białystok, ul. Mickiewicza 2C, 15-222 Białystok, Poland.
Malinowska B; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 02; Vol. 22 (9). Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article
MeSH Terms :
Amidohydrolases/*drug effects
Amidohydrolases/*metabolism
Benzamides/*pharmacology
Carbamates/*pharmacology
Endocannabinoids/*metabolism
Essential Hypertension/*metabolism
Essential Hypertension/*therapy
Acetylcholine ; Animals ; Aorta ; Arachidonic Acids ; Hypertension/metabolism ; Male ; Mesenteric Arteries/drug effects ; Nitroprusside ; Polyunsaturated Alkamides ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptors, Cannabinoid ; Vasoconstriction ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats.
Autorzy :
Hasegawa Y; Departments of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Kumamoto, Japan; Department of Pharmaceutical Science, School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1, Enokizu, Okawa, Fukuoka 8318501, Japan. Electronic address: .
Takemoto Y; Departments of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Kumamoto, Japan.
Hayashi K; Departments of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Kumamoto, Japan.
Kameno K; Departments of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Kumamoto, Japan.
Kim-Mitsuyama S; Departments of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Kumamoto, Japan.
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 May; Vol. 147, pp. 111286. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypertension*/drug therapy
Stroke*
Animals ; Blood Pressure ; Brain-Derived Neurotrophic Factor ; Humans ; Male ; Rats ; Rats, Inbred SHR ; Sodium Chloride, Dietary
Czasopismo naukowe
Tytuł :
Antihypertensive effect of rapeseed peptides and their potential in improving the effectiveness of captopril.
Autorzy :
Wang Y; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Li Y; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Ruan S; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Lu F; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Tian W; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Ma H; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
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Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2021 May; Vol. 101 (7), pp. 3049-3055. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antihypertensive Agents/*administration & dosage
Brassica napus/*chemistry
Hypertension/*drug therapy
Peptides/*administration & dosage
Angiotensin-Converting Enzyme Inhibitors/metabolism ; Animals ; Blood Pressure/drug effects ; Captopril/administration & dosage ; Drug Synergism ; Humans ; Hypertension/enzymology ; Hypertension/metabolism ; Hypertension/physiopathology ; Male ; Mice ; Mice, Inbred ICR ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Plant Proteins/chemistry ; Rats ; Rats, Inbred SHR
Czasopismo naukowe

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