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Title:
Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension.
Authors:
Shan R; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Zhang Y; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Shi Y; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Wang X; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Wang X; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Ma G; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Li Q; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.; Cardiovascular Research Platform, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang 050017, China.
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Source:
Biomolecules [Biomolecules] 2024 Mar 11; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 11.
Publication Type:
Journal Article
MeSH Terms:
Cannabinoids*/pharmacology
Hypertension*/drug therapy
Hypertension*/metabolism
Rats ; Mice ; Animals ; Neuroinflammatory Diseases ; Tumor Necrosis Factor-alpha/metabolism ; Microglia/metabolism ; Interleukin-6/metabolism ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Cannabinoid Receptor Agonists/pharmacology ; Rats, Inbred SHR ; Glycolysis ; Lactic Acid/metabolism ; Norepinephrine/metabolism
Academic Journal
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Title:
Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats.
Authors:
Madhyastha S; Department of Anatomy, College of Medicine, Kuwait University, Safat 13110, Kuwait.
Rao MS; Department of Anatomy, College of Medicine, Kuwait University, Safat 13110, Kuwait.
Renno WM; Department of Anatomy, College of Medicine, Kuwait University, Safat 13110, Kuwait.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 15; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 15.
Publication Type:
Journal Article
MeSH Terms:
Attention Deficit Disorder with Hyperactivity*
Humans ; Rats ; Animals ; Child ; Male ; Rats, Inbred SHR ; Adrenergic Agents/therapeutic use ; Serotonin 5-HT2 Receptor Antagonists/therapeutic use ; Serotonin 5-HT1 Receptor Agonists/therapeutic use ; Dopamine/metabolism ; Rats, Inbred WKY
Academic Journal
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Title:
Does Hypertension Affect the Recovery of Renal Functions after Reversal of Unilateral Ureteric Obstruction?
Authors:
Hammad FT; Department of Surgery, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Lubbad L; Department of Surgery, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Al-Salam S; Department of Pathology, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Hammad WF; School of Medicine, University of Jordan, Amman 11942, Jordan.
Yasin J; Department of Internal Medicine, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Meeran MFN; Department of Pharmacology and Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Ojha S; Department of Pharmacology and Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Arunachalam S; Department of Pharmacology and Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Hammad AF; School of Medicine, University of Jordan, Amman 11942, Jordan.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Publication Type:
Journal Article
MeSH Terms:
Ureteral Obstruction*/complications
Ureteral Obstruction*/pathology
Hypertension*
Rats ; Animals ; Rats, Inbred SHR ; Kidney/pathology ; Glomerular Filtration Rate
Academic Journal
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Title:
Function of Presynaptic Inhibitory Cannabinoid CB 1 Receptors in Spontaneously Hypertensive Rats and Its Modification by Enhanced Endocannabinoid Tone.
Authors:
Toczek M; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Mickiewicza Str. 2A, 15-222 Białystok, Poland.
Schlicker E; Department of Pharmacology and Toxicology, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Remiszewski P; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Mickiewicza Str. 2A, 15-222 Białystok, Poland.
Malinowska B; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Mickiewicza Str. 2A, 15-222 Białystok, Poland.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 10; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 10.
Publication Type:
Journal Article
MeSH Terms:
Cannabinoids*
Hypertension*
Carbamates*
Cyclohexanols*
Piperazines*
Succinimides*
Rats ; Animals ; Rats, Inbred WKY ; Endocannabinoids/pharmacology ; Rats, Inbred SHR ; Phenylephrine
Academic Journal
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Title:
Aliskiren-Loaded Nanoparticles Downregulate (Pro)renin Receptor and ACE Gene Expression in the Heart of Spontaneously Hypertensive Rats: Effect on NADPH Oxidase.
Authors:
Barta A; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Cebova M; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Kovac A; Institute of Neuroimunology, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Koneracka M; Institute of Experimental Physics, Slovak Academy of Sciences, 040 01 Kosice, Slovakia.
Zavisova V; Institute of Experimental Physics, Slovak Academy of Sciences, 040 01 Kosice, Slovakia.
Pechanova O; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.; Institute of Pathophysiology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 10; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 10.
Publication Type:
Journal Article
MeSH Terms:
Prorenin Receptor*
Nanoparticles*
Amides*
Fumarates*
Male ; Animals ; Rats ; Rats, Inbred SHR ; NADPH Oxidases/genetics ; Myocytes, Cardiac ; Polyenes ; Gene Expression
Academic Journal
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Title:
Impact of exercise training associated with enalapril treatment on blood pressure variability and renal dysfunctions in an experimental model of arterial hypertension and postmenopause.
Authors:
Dos Santos Ferreira Silva MP; Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.
Ferreira MJ; Exercise Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Shecaira TP; Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.; Exercise Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
da Silva Dias D; Exercise Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.; Hypertension Unit, Heart Institute (InCor), School of Medicine, Universidade de São Paulo (USP), São Paulo, SP, Brazil.; Postgraduate Program in Physical Education, Universidade Federal do Maranhão, São Luís, MA, Brazil.
Kimura DC; Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Irigoyen MC; Postgraduate Program in Physical Education, Universidade Federal do Maranhão, São Luís, MA, Brazil.
Gomes GN; Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
De Angelis K; Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.; Exercise Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
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Source:
PloS one [PLoS One] 2024 Jan 10; Vol. 19 (1), pp. e0296687. Date of Electronic Publication: 2024 Jan 10 (Print Publication: 2024).
Publication Type:
Journal Article
MeSH Terms:
Hypertension*/drug therapy
Nephritis*
Renal Insufficiency*
Female ; Animals ; Rats ; Blood Pressure ; Postmenopause ; Enalapril/pharmacology ; Rats, Inbred SHR ; Models, Theoretical
Academic Journal
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Title:
Antihypertensive effects of the combined extract of Sorghum bicolor, Vigna angularis, and Eleusine coracana in spontaneously hypertensive rats.
Authors:
Jeong E; Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Yun D; Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Baek Y; Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Kim HJ; Department of Central Area Crop Science, National Institute of Crop Science, Wanju-Gun, 55365, Korea.
Lee HG; Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea. .
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Source:
Scientific reports [Sci Rep] 2024 Jan 08; Vol. 14 (1), pp. 803. Date of Electronic Publication: 2024 Jan 08.
Publication Type:
Journal Article
MeSH Terms:
Eleusine*
Sorghum*
Vigna*
Rats ; Animals ; Rats, Inbred WKY ; Rats, Inbred SHR ; Antihypertensive Agents/pharmacology ; Dietary Supplements ; Plant Extracts/pharmacology
Academic Journal
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Title:
Hypertensive rats show increased renal excretion and decreased tissue concentrations of glycine betaine, a protective osmolyte with diuretic properties.
Authors:
Mogilnicka I; Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Jaworska K; Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Koper M; Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Maksymiuk K; Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Szudzik M; Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Radkiewicz M; Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Chabowski D; Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Ufnal M; Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
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Source:
PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0294926. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
Publication Type:
Journal Article
MeSH Terms:
Betaine*/pharmacology
Betaine*/metabolism
Hypertension*/genetics
Rats ; Animals ; Rats, Inbred WKY ; Diuretics/pharmacology ; Renal Elimination ; Kidney/metabolism ; Rats, Inbred SHR ; Blood Pressure ; Electrolytes/metabolism
Academic Journal
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Title:
Paeonol improves renal and vascular angiotensin II type 1 receptor function via inhibiting oxidative stress in spontaneously hypertensive rats.
Authors:
Wu T; Guangzhou University of Chinese Medicine, Guangzhou, China.; Department of Cardiology, The Second Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China.
Zheng Y; Department of Cardiology, The Second Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China.
Huang Q; Department of Cardiology, The Second Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China.
Tian S; Department of Cardiology, Guizhou Provincial People's Hospital, Guiyang, China.
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Source:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2023 Dec 31; Vol. 45 (1), pp. 2182884.
Publication Type:
Journal Article
MeSH Terms:
Renin*
Hypertension*/drug therapy
Rats ; Animals ; Rats, Inbred WKY ; Rats, Inbred SHR ; Receptor, Angiotensin, Type 1 ; Angiotensin II ; Kidney ; Oxidative Stress ; Vasoconstrictor Agents
Academic Journal
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Title:
Inhibition of endoplasmic reticulum stress restores the balance of renal RAS components and lowers blood pressure in the spontaneously hypertensive rats.
Authors:
Zhu J; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.; Department of Cardiology, Shanghai Hospital Wanzhou District, Chongqing, China.
Shao A; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.
Wang C; Department of Surgery, Third People's Hospital, Kaizhou District, Chongqing, China.
Zeng C; Department of Hematology, Chongqing Cancer Hospital, Chongqing, China.
Wang H; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.
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Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2023 Dec 31; Vol. 45 (1), pp. 2202367.
Publication Type:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/metabolism
Angiotensin-Converting Enzyme 2*/pharmacology
Hypertension*
Rats ; Animals ; Blood Pressure ; Rats, Inbred SHR ; Rats, Inbred WKY ; Kidney/metabolism ; Endoplasmic Reticulum Stress
Academic Journal
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Title:
Follistatin-like 1 protects endothelial function in the spontaneously hypertensive rat by inhibition of endoplasmic reticulum stress through AMPK-dependent mechanism.
Authors:
Liu H; Department of Neurosurgery, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
Li Y; Department of Neurosurgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Li M; Department of Neurosurgery, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
Xie L; Department of Neurosurgery, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
Li F; Department of Neurosurgery, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
Pan R; Operating room, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, China.
Pei F; Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
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Source:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2023 Dec 31; Vol. 45 (1), pp. 2277654. Date of Electronic Publication: 2023 Nov 14.
Publication Type:
Journal Article
MeSH Terms:
Follistatin-Related Proteins*/metabolism
Follistatin-Related Proteins*/pharmacology
Hypertension*
Rats ; Animals ; Rats, Inbred SHR ; AMP-Activated Protein Kinases/metabolism ; Follistatin/metabolism ; Follistatin/pharmacology ; Rats, Inbred WKY ; Reactive Oxygen Species/metabolism ; Endothelium, Vascular ; Mesenteric Arteries ; Endoplasmic Reticulum Stress
Academic Journal
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Title:
Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states.
Authors:
Morton L; Institute of Inflammation and Neurodegeneration, Medical Faculty, Health Campus Immunology, Infectiology, and Inflammation (GC-I3), Otto-von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.
Arndt P; Department of Neurology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; German Center for Neurodegenerative Diseases (DZNE) Helmholtz Association, Magdeburg, Germany.
Garza AP; Institute of Inflammation and Neurodegeneration, Medical Faculty, Health Campus Immunology, Infectiology, and Inflammation (GC-I3), Otto-von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.
Henneicke S; Department of Neurology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; German Center for Neurodegenerative Diseases (DZNE) Helmholtz Association, Magdeburg, Germany.
Mattern H; German Center for Neurodegenerative Diseases (DZNE) Helmholtz Association, Magdeburg, Germany.; Faculty of Natural Sciences, Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.
Gonzalez M; Institute of Inflammation and Neurodegeneration, Medical Faculty, Health Campus Immunology, Infectiology, and Inflammation (GC-I3), Otto-von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.
Dityatev A; German Center for Neurodegenerative Diseases (DZNE) Helmholtz Association, Magdeburg, Germany.; Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.
Yilmazer-Hanke D; Clinical Neuroanatomy, Department of Neurology, Institute for Biomedical Research, Ulm University, Ulm, Germany.
Schreiber S; Department of Neurology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; German Center for Neurodegenerative Diseases (DZNE) Helmholtz Association, Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Jena-Magdeburg-Halle, Germany.
Dunay IR; Institute of Inflammation and Neurodegeneration, Medical Faculty, Health Campus Immunology, Infectiology, and Inflammation (GC-I3), Otto-von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany. .; Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany. .; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany. .; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Jena-Magdeburg-Halle, Germany. .
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Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Dec 19; Vol. 11 (1), pp. 204. Date of Electronic Publication: 2023 Dec 19.
Publication Type:
Journal Article; Review
MeSH Terms:
Hypertension*/complications
Hypertension*/pathology
Cerebral Small Vessel Diseases*/pathology
Rats ; Humans ; Mice ; Animals ; Microglia/metabolism ; Rats, Inbred SHR ; Phenotype
Academic Journal
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Title:
In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys.
Authors:
Lee B; Department of Biomedicine, The University of Copenhagen, 2100, Copenhagen, Denmark. .
Postnov DD; CFIN Department of Clinical Medicine, Aarhus University, 1710, Aarhus, Denmark.
Sørensen CM; Department of Biomedicine, The University of Copenhagen, 2100, Copenhagen, Denmark.
Sosnovtseva O; Department of Biomedicine, The University of Copenhagen, 2100, Copenhagen, Denmark.
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Source:
Scientific reports [Sci Rep] 2023 Dec 11; Vol. 13 (1), pp. 21954. Date of Electronic Publication: 2023 Dec 11.
Publication Type:
Journal Article
MeSH Terms:
Kidney Glomerulus*
Hypertension*
Rats ; Animals ; Blood Pressure ; Feedback ; Renal Circulation ; Rats, Sprague-Dawley ; Kidney ; Hemodynamics/physiology ; Glomerular Filtration Rate ; Rats, Inbred SHR ; Kidney Tubules/blood supply
Academic Journal
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Title:
Qiqilian ameliorates vascular endothelial dysfunction by inhibiting NLRP3-ASC inflammasome activation in vivo and in vitro .
Authors:
Luo Y; The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, P.R. China.
Tan Z; Guangxi Medical University, Nanning, P.R. China.
Ye Y; No. 923 Hospital of the PLA Joint Logistics Support Force, Nanning, P.R. China.
Ma X; Guangxi University of Chinese Medicine, Nanning, P.R. China.
Yue G; Guangxi Internation Zhuang Medicine Hospital to Guangxi University of Chinese Medicine, Nanning, P.R. China.; Guangxi Internation Zhuang Medicine Hospital, Nanning, P.R. China.
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Source:
Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 815-824.
Publication Type:
Journal Article
MeSH Terms:
Hypertension*/drug therapy
Inflammasomes*
Animals ; Humans ; Rats ; Human Umbilical Vein Endothelial Cells ; Interleukin-18/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Rats, Inbred SHR ; Rats, Inbred WKY
Academic Journal
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Title:
Role of K Channels in the Vasodilator Effects of Plectranthus barbatus (Brazilian Boldo) in Hypertensive Rats.
Authors:
Moser JC; Postgraduate Program in Pharmaceutical Sciences, Nucleus of Chemical-Pharmaceutical Investigations, University of Vale do Itajaí, Itajaí, Brazil.
da Silva RCV; Postgraduate Program in Pharmaceutical Sciences, Nucleus of Chemical-Pharmaceutical Investigations, University of Vale do Itajaí, Itajaí, Brazil.
Costa P; Postgraduate Program in Pharmaceutical Sciences, Nucleus of Chemical-Pharmaceutical Investigations, University of Vale do Itajaí, Itajaí, Brazil.
da Silva LM; Postgraduate Program in Pharmaceutical Sciences, Nucleus of Chemical-Pharmaceutical Investigations, University of Vale do Itajaí, Itajaí, Brazil.
Cassemiro NS; Laboratory of Natural Products and Mass Spectrometry, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Gasparotto Junior A; Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Silva DB; Laboratory of Natural Products and Mass Spectrometry, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
de Souza P; Postgraduate Program in Pharmaceutical Sciences, Nucleus of Chemical-Pharmaceutical Investigations, University of Vale do Itajaí, Itajaí, Brazil.
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Source:
Cardiovascular therapeutics [Cardiovasc Ther] 2023 Nov 17; Vol. 2023, pp. 9948707. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).
Publication Type:
Journal Article
MeSH Terms:
Plectranthus*
Peumus*
Hypertension*
Rats ; Animals ; Vasodilator Agents/pharmacology ; Vasodilation ; Brazil ; Rats, Inbred SHR ; Enzyme Inhibitors/pharmacology ; Endothelium, Vascular
Academic Journal
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Title:
Bioactive Peptides from Ruditapes philippinarum Attenuate Hypertension and Cardiorenal Damage in Deoxycorticosterone Acetate-Salt Hypertensive Rats.
Authors:
Sun Z; College of Life Sciences, Qingdao University, Qingdao 266071, China.
Wang W; Qingdao Chenlan Pharmaceutical Co., Ltd., Qingdao 266061, China.
Liu J; Qingdao Chenlan Pharmaceutical Co., Ltd., Qingdao 266061, China.
Zou S; Qingdao Chenlan Pharmaceutical Co., Ltd., Qingdao 266061, China.
Yin D; Qingdao Chenlan Pharmaceutical Co., Ltd., Qingdao 266061, China.
Lyu C; Qingdao Chenlan Pharmaceutical Co., Ltd., Qingdao 266061, China.
Yu J; College of Life Sciences, Qingdao University, Qingdao 266071, China.
Wei Y; College of Life Sciences, Qingdao University, Qingdao 266071, China.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2023 Nov 15; Vol. 28 (22). Date of Electronic Publication: 2023 Nov 15.
Publication Type:
Journal Article
MeSH Terms:
Desoxycorticosterone*/adverse effects
Hypertension*/chemically induced
Hypertension*/drug therapy
Humans ; Rats ; Animals ; Rats, Inbred SHR ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Peptides/pharmacology ; Acetates/pharmacology
Academic Journal
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Title:
Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke.
Authors:
Telianidis J; Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Hunter A; Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Widdop R; Department Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Kemp-Harper B; Department Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Pham V; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
McCarthy C; Department Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Chai SY; Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. .
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Source:
Scientific reports [Sci Rep] 2023 Nov 13; Vol. 13 (1), pp. 19722. Date of Electronic Publication: 2023 Nov 13.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cystinyl Aminopeptidase*/antagonists & inhibitors
Cystinyl Aminopeptidase*/metabolism
Ischemic Stroke*/drug therapy
Animals ; Mice ; Rats ; Infarction ; Neuroprotection ; Rats, Inbred SHR
Academic Journal
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Title:
Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents.
Authors:
Prieto I; Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.
Segarra AB; Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.
Banegas I; Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.
Martínez-Cañamero M; Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.
Durán R; Department of Physiology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.
Vives F; Department of Physiology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.
Domínguez-Vías G; Department of Physiology, Faculty of Health Sciences, Ceuta Campus, University of Granada, 18071 Granada, Spain.
Ramírez-Sánchez M; Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 06; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 06.
Publication Type:
Journal Article
MeSH Terms:
Captopril*/pharmacology
Hypertension*/drug therapy
Rats ; Animals ; Rats, Inbred SHR ; NG-Nitroarginine Methyl Ester/pharmacology ; Blood Pressure ; Hypothalamus ; Aminopeptidases ; Frontal Lobe
Academic Journal
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Title:
Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway.
Authors:
Liang Y; Department of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Zhou Y; Department of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Wang J; Health Management Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
He Y; Department of Geriatrics Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
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Source:
Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Oct; Vol. 11 (10), pp. e1003.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atrial Fibrillation*/genetics
Atrial Fibrillation*/drug therapy
Atrial Fibrillation*/pathology
Animals ; Rats ; Collagen ; Down-Regulation ; Fibromodulin/genetics ; Fibromodulin/metabolism ; Fibrosis ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Myeloid Differentiation Factor 88/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Rats, Inbred SHR ; RNA, Messenger/metabolism ; Signal Transduction ; Stroke Volume ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Transforming Growth Factor beta1/metabolism ; Ventricular Function, Left
Academic Journal
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Title:
Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway.
Authors:
Yuan W; Department of Neurosurgery, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China.
Fan H; Department of Neurosurgery, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China.
Yang H; Department of Cardiology, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China.
Tang L; Department of Cardiology, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China.
Liu Z; Department of Neurosurgery, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China.
Ouyang F; Department of Cardiology, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China. .
Luo W; Department of Neurosurgery, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China. .
Yan Y; Department of Neurosurgery, Central Hospital of Zhuzhou, No. 116, Changjiang South Road, Tianyuan District, 412000, Zhuzhou, Hunan, China. .
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Source:
Diagnostic pathology [Diagn Pathol] 2023 Sep 28; Vol. 18 (1), pp. 108. Date of Electronic Publication: 2023 Sep 28.
Publication Type:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use
Humans ; Rats ; Animals ; Aged ; Atorvastatin/pharmacology ; Janus Kinases ; Rats, Inbred SHR ; Signal Transduction ; STAT Transcription Factors ; Essential Hypertension/drug therapy ; Amlodipine ; Hydroxymethylglutaryl CoA Reductases
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Showing 1-20 from 1613 results

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