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Tytuł :
Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats.
Autorzy :
Li Y; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China. Electronic address: .
Zafar S; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China; University Institute of Physical Therapy, University of Lahore, Lahore, Pakistan.
Salih Ibrahim RM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China.
Chi HL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China.
Xiao T; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China.
Xia WJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China.
Li HB; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China. Electronic address: .
Kang YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119097. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Dietary Supplements*
Physical Conditioning, Animal*
Antioxidants/*administration & dosage
Ascorbic Acid/*administration & dosage
Gastrointestinal Microbiome/*drug effects
Hypertension/*prevention & control
Animals ; Blood Pressure ; Combined Modality Therapy ; Cytokines/metabolism ; Hypertension/etiology ; Hypertension/pathology ; Oxidative Stress ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
The antihypertension effect of hydrogen sulfide (H 2 S) is induced by activating VEGFR2 signaling pathway.
Autorzy :
Zhu ML; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Zhao FR; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China. Electronic address: .
Zhu TT; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China. Electronic address: .
Wang QQ; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Wu ZQ; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Song P; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Xu J; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Wan GR; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Yin YL; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China. Electronic address: .
Li P; College of Pharmacy, Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 15; Vol. 267, pp. 118831. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension/*drug therapy
Hypertension/*metabolism
Morpholines/*pharmacology
Organothiophosphorus Compounds/*pharmacology
Animals ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Hypertension/blood ; Male ; Malondialdehyde/blood ; Oxidative Stress/drug effects ; Protective Agents/pharmacology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Signal Transduction/drug effects ; Superoxide Dismutase/blood ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Therapeutic effects of losartan on prostatic hyperplasia in spontaneously hypertensive rats.
Autorzy :
Shimizu S; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.
Nagao Y; Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Japan.
Shimizu T; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.
Higashi Y; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.
Karashima T; Department of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Saito M; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118924. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antihypertensive Agents/*pharmacology
Hypertension/*complications
Losartan/*pharmacology
Prostatic Hyperplasia/*drug therapy
Animals ; Blood Pressure ; Male ; Malondialdehyde/metabolism ; Oxidative Stress ; Prostatic Hyperplasia/etiology ; Prostatic Hyperplasia/pathology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
The dynamic change of phenotypic markers of smooth muscle cells in an animal model of cerebral small vessel disease.
Autorzy :
Liu N; Department of Neurology, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai 200040, China.
Xue Y; Department of Neurology, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai 200040, China.
Tang J; Department of Neurology, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai 200040, China.
Zhang M; Department of Neurology, North Huashan hospital, Fudan University, No.108 Lu Xiang Road, Shanghai 201900, China.
Ren X; Department of Neurology, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai 200040, China.
Fu J; Department of Neurology, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai 200040, China; Department of Neurology, North Huashan hospital, Fudan University, No.108 Lu Xiang Road, Shanghai 201900, China. Electronic address: .
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Źródło :
Microvascular research [Microvasc Res] 2021 Jan; Vol. 133, pp. 104061. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Small Vessel Diseases/*etiology
Extracellular Matrix/*metabolism
Hypertension/*complications
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Age Factors ; Animals ; Biomarkers/metabolism ; Cells, Cultured ; Cerebral Arteries/metabolism ; Cerebral Arteries/pathology ; Cerebral Arteries/physiopathology ; Cerebral Small Vessel Diseases/metabolism ; Cerebral Small Vessel Diseases/pathology ; Cerebral Small Vessel Diseases/physiopathology ; Disease Models, Animal ; Extracellular Matrix/pathology ; Fibronectins/metabolism ; Hypertension/metabolism ; Hypertension/physiopathology ; Laminin/metabolism ; Male ; Muscle, Smooth, Vascular/pathology ; Muscle, Smooth, Vascular/physiopathology ; Myocytes, Smooth Muscle/pathology ; Phenotype ; Rats, Inbred SHR ; Rats, Inbred WKY ; Vascular Remodeling ; Vasoconstriction
Czasopismo naukowe
Tytuł :
Diets enriched with coconut, fish, or olive oil modify peripheral metabolic effects of ozone in rats.
Autorzy :
Snow SJ; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Henriquez AR; Oak Ridge Institute for Science and Education Research Participation Program, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Fenton JI; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48824, United States.
Goeden T; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48824, United States.
Fisher A; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Vallanat B; Center for Computational Toxicology and Exposure, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Angrish M; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Richards JE; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Schladweiler MC; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Cheng WY; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Wood CE; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Tong H; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Kodavanti UP; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115337. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coconut Oil/*metabolism
Dietary Fats, Unsaturated/*metabolism
Fish Oils/*metabolism
Olive Oil/*metabolism
Ozone/*metabolism
Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; Coconut Oil/administration & dosage ; Dietary Fats, Unsaturated/administration & dosage ; Fish Oils/administration & dosage ; Liver/drug effects ; Liver/metabolism ; Male ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Olive Oil/administration & dosage ; Ozone/administration & dosage ; Rats ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response.
Autorzy :
Aleksandrova LR; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Wang YT; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address: .
Phillips AG; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. Electronic address: .
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Źródło :
Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2019 Oct; Vol. 105, pp. 1-23. Date of Electronic Publication: 2019 Jul 20.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Depressive Disorder, Major*/drug therapy
Depressive Disorder, Major*/metabolism
Depressive Disorder, Major*/physiopathology
Disease Models, Animal*
Hippocampus*/drug effects
Hippocampus*/physiopathology
Nerve Net*/drug effects
Nerve Net*/physiopathology
Neuronal Plasticity*/drug effects
Neuronal Plasticity*/physiology
Prefrontal Cortex*/drug effects
Prefrontal Cortex*/physiopathology
Rats, Inbred WKY*
Antidepressive Agents/*pharmacology
Ketamine/*pharmacology
Animals ; Rats
Czasopismo naukowe
Tytuł :
Taxifolin improves disorders of glucose metabolism and water-salt metabolism in kidney via PI3K/AKT signaling pathway in metabolic syndrome rats.
Autorzy :
Gao L; Henan University of Chinese Medicine, Zhengzhou 450046, China.
Yuan P; Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhang Q; Henan University of Chinese Medicine, Zhengzhou 450046, China.
Fu Y; Henan University of Chinese Medicine, Zhengzhou 450046, China.
Hou Y; Henan University of Chinese Medicine, Zhengzhou 450046, China.
Wei Y; Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zheng X; Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. Electronic address: .
Feng W; Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Dec 15; Vol. 263, pp. 118713. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Glucose/*metabolism
Insulin/*metabolism
Metabolic Syndrome/*drug therapy
Quercetin/*analogs & derivatives
Animals ; Blood Pressure/drug effects ; Disease Models, Animal ; Insulin Resistance ; Kidney/cytology ; Kidney/metabolism ; Male ; Metabolic Syndrome/physiopathology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Quercetin/pharmacology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Renin-Angiotensin System/drug effects ; Signal Transduction/drug effects ; Sodium/metabolism ; Water/metabolism ; Water-Electrolyte Balance/drug effects
Czasopismo naukowe
Tytuł :
Fish oil and olive oil-enriched diets alleviate acute ozone-induced cardiovascular effects in rats.
Autorzy :
Tong H; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Chapel Hill, NC 27514, United States. Electronic address: .
Snow SJ; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States.
Chen H; Oak Ridge Institute of Science and Education, Oak Ridge, TN 37830, United States. Electronic address: .
Schladweiler MC; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: .
Carswell G; Biomolecular and Computational Toxicology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: .
Chorley B; Biomolecular and Computational Toxicology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: .
Kodavanti UP; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Dec 15; Vol. 409, pp. 115296. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cardiovascular System/*drug effects
Fish Oils/*pharmacology
Olive Oil/*pharmacology
Ozone/*adverse effects
Animals ; Cardiovascular System/metabolism ; Diet ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Male ; MicroRNAs/metabolism ; Rats ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension.
Autorzy :
Yuan Y; College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Naito H; Department of Public Health, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.; College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Aichi, Japan.
Kitamori K; College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Aichi, Japan.
Hashimoto S; College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Aichi, Japan.
Asano T; College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Aichi, Japan.
Nakajima T; College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
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Źródło :
PloS one [PLoS One] 2020 Dec 14; Vol. 15 (12), pp. e0243846. Date of Electronic Publication: 2020 Dec 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Antihypertensive Agents/*therapeutic use
Extracellular Matrix/*metabolism
Hydralazine/*therapeutic use
Hypertension/*complications
Hypertension/*drug therapy
Liver Cirrhosis/*drug therapy
Non-alcoholic Fatty Liver Disease/*drug therapy
Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Body Weight/drug effects ; Cholesterol, Dietary ; Cytokines/blood ; Diet, High-Fat ; Gene Expression Regulation/drug effects ; Hydralazine/administration & dosage ; Hydralazine/pharmacology ; Hypertension/physiopathology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Liver Cirrhosis/pathology ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Matrix Metalloproteinases/blood ; Models, Biological ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/pathology ; Organ Size/drug effects ; Rats, Inbred SHR ; Rats, Inbred WKY ; Tissue Inhibitor of Metalloproteinase-1/blood
Czasopismo naukowe
Tytuł :
Analyzing the magnitude effect in spontaneously hypertensive (SHR) and wistar Kyoto (WKY) rats.
Autorzy :
Aparicio CF; Salem State University, United States. Electronic address: .
Malonson M; Salem State University, United States.
Hensley J; Salem State University, United States.
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Źródło :
Behavioural processes [Behav Processes] 2020 Dec; Vol. 181, pp. 104258. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Impulsive Behavior*
Animals ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
Study on ferroptosis pathway that operates in hypertensive brain damage.
Autorzy :
Yang J; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin, China.
Wang M; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin, China.
Wang S; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin, China.
Li G; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin, China.
Gao Y; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin, China.
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Źródło :
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2020 Nov 16; Vol. 42 (8), pp. 748-752. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Ferroptosis*
Brain/*pathology
Hypertension/*pathology
Animals ; Blood Pressure ; Brain/metabolism ; Hypertension/metabolism ; Hypertension/physiopathology ; Lipid Peroxidation ; Male ; Oxidative Stress/physiology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
Renoprotective and haemodynamic effects of adiponectin and peroxisome proliferator-activated receptor agonist, pioglitazone, in renal vasculature of diabetic Spontaneously hypertensive rats.
Autorzy :
Afzal S; School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia.; Faculty of Pharmacy, MAHSA University, Selangor, Malaysia.
Abdul Sattar M; School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia.; Faculty of Pharmacy, MAHSA University, Selangor, Malaysia.
Johns EJ; Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria.
Eseyin OA; School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia.; Department of Physiology, University College Cork, Cork, Ireland.
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Źródło :
PloS one [PLoS One] 2020 Nov 10; Vol. 15 (11), pp. e0229803. Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hemodynamics*
Adiponectin/*pharmacology
Diabetes Mellitus, Experimental/*complications
Hypertension/*complications
Kidney Diseases/*prevention & control
Neovascularization, Pathologic/*prevention & control
Pioglitazone/*pharmacology
Animals ; Diabetes Mellitus, Experimental/drug therapy ; Hypertension/drug therapy ; Hypoglycemic Agents/pharmacology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Neovascularization, Pathologic/etiology ; Neovascularization, Pathologic/pathology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Renal Circulation
Czasopismo naukowe
Tytuł :
Association of Neutrophil Extracellular Traps with the Development of Idiopathic Osteonecrosis of the Femoral Head.
Autorzy :
Nonokawa M; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Shimizu T; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yoshinari M; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Hashimoto Y; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Nakamura Y; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Takahashi D; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Asano T; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Nishibata Y; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Masuda S; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Nakazawa D; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Tanaka S; Center for Cause of Death Investigation, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Tomaru U; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Iwasaki N; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Ishizu A; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Nov; Vol. 190 (11), pp. 2282-2289. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Extracellular Traps/*metabolism
Femur Head/*metabolism
Femur Head Necrosis/*metabolism
Neutrophils/*metabolism
Aged ; Aged, 80 and over ; Animals ; Disease Models, Animal ; Female ; Femur Head/blood supply ; Femur Head/pathology ; Femur Head Necrosis/pathology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male ; Middle Aged ; Neutrophils/pathology ; Rats ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
A novel time-dimension and circadian rhythm-dependent strategy for pharmacodynamic evaluation of Uncaria in the regulation of neurotransmitter circadian metabolic homeostasis in spontaneously hypertensive rats.
Autorzy :
Sun M; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Wang H; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Gong L; Experiment Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China.
Qi D; Experiment Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China.
Wang X; Experiment Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China. Electronic address: .
Li Y; TCM Clinical Research Base for Hypertension, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, China. Electronic address: .
Jiang H; Experiment Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110704. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Homeostasis*
Uncaria*
Circadian Rhythm/*physiology
Hypertension/*drug therapy
Metabolomics/*methods
Neurotransmitter Agents/*metabolism
Plant Extracts/*pharmacology
Animals ; Blood Pressure/drug effects ; Hypertension/metabolism ; Male ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
Tyrosine hydroxylase and β2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity.
Autorzy :
Nisimura LM; Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.; Laboratório de Investigação Cardiovascular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Bousquet P; Department of Pharmacology, Faculty of Medicine, University of Strasbourg, Strasbourg, France.
Muccillo F; Instituto Nacional de Cardiologia, Ministério da Saúde, Rio de Janeiro, RJ, Brasil.
Tibirica E; Laboratório de Investigação Cardiovascular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.; Instituto Nacional de Cardiologia, Ministério da Saúde, Rio de Janeiro, RJ, Brasil.
Garzoni LR; Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
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Źródło :
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2020 Oct 30; Vol. 53 (12), pp. e9615. Date of Electronic Publication: 2020 Oct 30 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension*/drug therapy
Animals ; Blood Pressure ; Leukocytes ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptors, Adrenergic, beta-2 ; Sympathetic Nervous System ; Tyrosine 3-Monooxygenase
Czasopismo naukowe
Tytuł :
Comprehensive characterisation of phenolics from Nitraria sibirica leaf extracts by UHPLC-quadrupole-orbitrap- MS and evaluation of their anti-hypertensive activity.
Autorzy :
Turghun C; The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of the Chinese Academy of Sciences, 100049, Beijing, China.
Bakri M; The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
Abdulla R; The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
Ma Q; The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
Aisa HA; The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Oct 28; Vol. 261, pp. 113019. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid*
Magnoliopsida*/chemistry
Plant Leaves*/chemistry
Tandem Mass Spectrometry*
Antihypertensive Agents/*pharmacology
Blood Pressure/*drug effects
Hypertension/*drug therapy
Phenols/*pharmacology
Animals ; Antihypertensive Agents/isolation & purification ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Biomarkers/blood ; Disease Models, Animal ; Hypertension/blood ; Hypertension/physiopathology ; Kidney/drug effects ; Kidney/metabolism ; Lipids/blood ; Male ; Oxidative Stress/drug effects ; Phenols/isolation & purification ; Rats, Inbred SHR ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
Age- and Phenotype-Dependent Changes in Circulating MMP-2 and MMP-9 Activities in Normotensive and Hypertensive Rats.
Autorzy :
Kollarova M; Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovakia.
Puzserova A; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal and Pathological Physiology, 813 71 Bratislava, Slovakia.
Balis P; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal and Pathological Physiology, 813 71 Bratislava, Slovakia.
Radosinska D; Faculty of Natural Sciences, Comenius University in Bratislava, 842 15 Bratislava, Slovakia.
Tothova L; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovakia.
Bartekova M; Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovakia.; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute for Heart Research, 841 04 Bratislava, Slovakia.
Barancik M; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute for Heart Research, 841 04 Bratislava, Slovakia.
Radosinska J; Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovakia.; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute for Heart Research, 841 04 Bratislava, Slovakia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 02; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Aging/*blood
Hypertension/*blood
Matrix Metalloproteinase 2/*blood
Matrix Metalloproteinase 9/*blood
Age Factors ; Aging/pathology ; Animals ; Antioxidants/metabolism ; Blood Pressure ; Humans ; Hypertension/genetics ; Hypertension/pathology ; Oxidative Stress/genetics ; Phenotype ; Rats ; Rats, Inbred SHR/blood ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
Quercetin improves vascular endothelial function through promotion of autophagy in hypertensive rats.
Autorzy :
Lin X; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an 710004, Shaanxi, China; Department of Neurology, The First Hospital of Xi'an, No. 30, Fengxiang Road, South Street, Xi'an 710002, Shaanxi, China.
Han T; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an 710004, Shaanxi, China.
Fan Y; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an 710004, Shaanxi, China.
Wu S; Department of Neurology, The First Hospital of Xi'an, No. 30, Fengxiang Road, South Street, Xi'an 710002, Shaanxi, China.
Wang F; Department of Neurology, The First Hospital of Xi'an, No. 30, Fengxiang Road, South Street, Xi'an 710002, Shaanxi, China.
Wang C; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an 710004, Shaanxi, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118106. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*drug effects
Endothelium, Vascular/*pathology
Endothelium, Vascular/*physiopathology
Hypertension/*physiopathology
Quercetin/*pharmacology
Animals ; Blood Pressure/drug effects ; Endothelium, Vascular/drug effects ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/physiopathology ; Oxidative Stress/drug effects ; Rats, Inbred SHR ; Rats, Inbred WKY
Czasopismo naukowe
Tytuł :
A "Western Diet" promotes symptoms of hepatic steatosis in spontaneously hypertensive rats.
Autorzy :
Cartland SP; Heart Research Institute, Sydney, NSW, Australia.; Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia.
Tamer N; Heart Research Institute, Sydney, NSW, Australia.
Patil MS; Heart Research Institute, Sydney, NSW, Australia.
Di Bartolo BA; Heart Research Institute, Sydney, NSW, Australia.; Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia.; Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, NSW, Australia.
Kavurma MM; Heart Research Institute, Sydney, NSW, Australia.; Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia.
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Źródło :
International journal of experimental pathology [Int J Exp Pathol] 2020 Oct; Vol. 101 (5), pp. 152-161. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet, High-Fat/*adverse effects
Fatty Liver/*etiology
Hypertension/*complications
Non-alcoholic Fatty Liver Disease/*complications
Non-alcoholic Fatty Liver Disease/*etiology
Animals ; Blood Pressure ; Cholesterol/blood ; Fatty Liver/physiopathology ; Hypertension/physiopathology ; Liver/physiopathology ; Male ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Triglycerides/blood
Czasopismo naukowe
Tytuł :
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Autorzy :
Ye C; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiong W; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lei CT; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tang H; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Su H; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yi F; Department of Pharmacology, School of Basic Medical Science, Shandong University, Jinan, China.
Zhang C; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Oct 01; Vol. 319 (4), pp. F636-F646. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*/drug effects
Epithelial Cells/*metabolism
Glomerulonephritis/*enzymology
Kidney Glomerulus/*metabolism
Mad2 Proteins/*metabolism
S-Phase Kinase-Associated Proteins/*metabolism
Animals ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Etanercept/pharmacology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Gene Expression Regulation ; Glomerulonephritis/drug therapy ; Glomerulonephritis/genetics ; Glomerulonephritis/pathology ; Glucocorticoids/pharmacology ; Humans ; Kidney Glomerulus/drug effects ; Kidney Glomerulus/pathology ; Mad2 Proteins/genetics ; Male ; Mice ; Prednisolone/analogs & derivatives ; Prednisolone/pharmacology ; RAW 264.7 Cells ; Rats, Inbred WKY ; S-Phase Kinase-Associated Proteins/genetics ; Signal Transduction
Czasopismo naukowe

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