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Tytuł :
Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats.
Autorzy :
Nishitani A; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Nagayoshi H; Osaka Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan.
Takenaka S; Department of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, 3-7-30 Habikino, Osaka 583-8555, Japan.
Asano M; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Shimizu S; Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Ohno Y; Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Kuramoto T; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, 1737 Funako, Atsugi, Kanagawa 243-0034, Japan.
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Źródło :
Experimental animals [Exp Anim] 2020 Nov 12; Vol. 69 (4), pp. 388-394. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Amidohydrolases/*genetics
Essential Tremor/*genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*genetics
Potassium Channels/*genetics
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*physiology
Amidohydrolases/metabolism ; Animals ; Brain/metabolism ; Essential Tremor/drug therapy ; Gene Knockout Techniques ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Molecular Targeted Therapy ; Phenols/pharmacology ; Phenols/therapeutic use ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Potassium Channels/metabolism ; Quinoxalines/pharmacology ; Quinoxalines/therapeutic use ; Rats, Inbred F344 ; Rats, Mutant Strains ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Complement C6 deficiency exacerbates pathophysiology after spinal cord injury.
Autorzy :
Su D; Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
Hooshmand MJ; Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, Irvine, CA, USA.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA.
Galvan MD; Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
Nishi RA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA.
Cummings BJ; Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, Irvine, CA, USA.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA.; Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA, USA.
Anderson AJ; Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA. .; Institute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, Irvine, CA, USA. .; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA. .; Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 11; Vol. 10 (1), pp. 19500. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Complement C6/*deficiency
Hereditary Complement Deficiency Diseases/*complications
Spinal Cord Injuries/*metabolism
Spinal Cord Injuries/*physiopathology
Animals ; Behavior, Animal ; Complement C6/genetics ; Complement Membrane Attack Complex/genetics ; Complement Membrane Attack Complex/metabolism ; Disease Models, Animal ; Female ; Genotype ; Glial Fibrillary Acidic Protein/metabolism ; Gray Matter/cytology ; Gray Matter/metabolism ; Hereditary Complement Deficiency Diseases/genetics ; Heterozygote ; Locomotion ; Male ; Myelin Basic Protein/metabolism ; Rats, Mutant Strains ; Selective Breeding ; Spinal Cord Injuries/etiology ; Spinal Cord Injuries/genetics ; Thoracic Vertebrae/injuries ; White Matter/cytology ; White Matter/metabolism
SCR Disease Name :
Complement Component 6 Deficiency
Czasopismo naukowe
Tytuł :
Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction.
Autorzy :
Lin B; Physical Medicine & Rehabilitation, Sue & Bill Gross Stem Cell Research Center, University of California at Irvine, School of Medicine, Irvine, California, United States.
McLelland BT; Physical Medicine & Rehabilitation, Sue & Bill Gross Stem Cell Research Center, University of California at Irvine, School of Medicine, Irvine, California, United States.
Aramant RB; Physical Medicine & Rehabilitation, Sue & Bill Gross Stem Cell Research Center, University of California at Irvine, School of Medicine, Irvine, California, United States.
Thomas BB; USC Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, California, United States.
Nistor G; AIVITA Biomedical Inc., Irvine, California, United States.
Keirstead HS; AIVITA Biomedical Inc., Irvine, California, United States.
Seiler MJ; Physical Medicine & Rehabilitation, Sue & Bill Gross Stem Cell Research Center, University of California at Irvine, School of Medicine, Irvine, California, United States.; Ophthalmology, University of California at Irvine, School of Medicine, Irvine, California, United States.; Anatomy & Neurobiology, University of California at Irvine School of Medicine, Irvine, California, United States.
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Sep 01; Vol. 61 (11), pp. 34.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Photoreceptor Cells/*metabolism
Retinal Degeneration/*metabolism
Retinal Pigment Epithelium/*physiopathology
Animals ; Disease Models, Animal ; Humans ; Organoids/metabolism ; Organoids/transplantation ; Photoreceptor Cells/pathology ; Rats ; Rats, Mutant Strains ; Retinal Degeneration/pathology ; Retinal Degeneration/physiopathology ; Retinal Pigment Epithelium/pathology ; Tomography, Optical Coherence
Czasopismo naukowe
Tytuł :
The deficiency of myelin in the mutant taiep rat induces a differential immune response related to protection from the human parasite Trichinella spiralis.
Autorzy :
Nava-Castro KE; Laboratorio de Genotoxicología y Mutagénesis Ambientales, Departamento de Genotoxicología y Medicina Ambientales, Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Ciudad de México, México.
Cortes C; Institute of Physiology, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Eguibar JR; Institute of Physiology, Benemérita Universidad Autónoma de Puebla, Puebla, México.; Research Office of the Vice-Rectory of Research and Postgraduate Studies, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Del Rio-Araiza VH; Departamento de Parasitología, Facultad de Veterinaria, Universidad Nacional Autónoma de México, Ciudad de México, México.
Hernández-Bello R; Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
Morales-Montor J; Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México.
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Źródło :
PloS one [PLoS One] 2020 Aug 20; Vol. 15 (8), pp. e0231803. Date of Electronic Publication: 2020 Aug 20 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Myelin Sheath/*genetics
Myelin Sheath/*metabolism
Trichinella spiralis/*pathogenicity
Animals ; Demyelinating Diseases/pathology ; Disease Models, Animal ; Male ; Parasites ; Rats ; Rats, Mutant Strains/immunology ; Rats, Sprague-Dawley/genetics ; Rats, Sprague-Dawley/immunology ; Tremor/pathology ; Trichinella spiralis/metabolism
Czasopismo naukowe
Tytuł :
Postnatal morphological lung development of wild type and CD26/DPP4 deficient rat pups in dependency of LPS exposure.
Autorzy :
Wagener I; Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Electronic address: .
Jungen M; Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Electronic address: .
von Hörsten S; Franz-Penzoldt-Centre, Experimental Therapy, Friedrich-Alexander-University of Erlangen, Germany. Electronic address: .
Stephan M; Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany; Clinic for Psychosomatics and Psychotherapy, Hannover Medical School, 30625 Hannover, Germany. Electronic address: .
Schmiedl A; Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Electronic address: .
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Źródło :
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft [Ann Anat] 2020 May; Vol. 229, pp. 151423. Date of Electronic Publication: 2019 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Dipeptidyl Peptidase 4/*deficiency
Lipopolysaccharides/*pharmacology
Lung/*growth & development
Rats, Inbred F344/*growth & development
Animals ; Body Weight ; Lung/drug effects ; Lung Volume Measurements ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/growth & development ; Rats ; Rats, Mutant Strains
Czasopismo naukowe
Tytuł :
Age-related behavioral, morphological and physiological changes in the hippocampus of zitter rats.
Autorzy :
Ehara A; Department of Histology and Neurobiology, Dokkyo Medical University School of Medicine, Mibu, Tochigi, 321-0293, Japan.
Maekawa M; Department of Physiology and Biological Information, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Hori Y; Department of Physiology and Biological Information, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Nakadate K; Department of Basic Biology, Educational and Research Center for Pharmacy, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.
Ueda S; Department of Histology and Neurobiology, Dokkyo Medical University School of Medicine, Mibu, Tochigi, 321-0293, Japan. .
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Źródło :
Anatomical science international [Anat Sci Int] 2018 Jun; Vol. 93 (3), pp. 332-339. Date of Electronic Publication: 2017 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Rats, Mutant Strains*
Aging/*pathology
Aging/*physiology
Hippocampus/*pathology
Hippocampus/*physiopathology
Seizures/*etiology
Animals ; Female ; Male ; Nerve Degeneration ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Porous gold layer coated silver nanoplates with efficient antimicrobial activity.
Autorzy :
Zhu J; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China; Shenzhen Research Institute of Nanjing University, Shenzhen, 518057, China.
Liu S; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China; Shenzhen Research Institute of Nanjing University, Shenzhen, 518057, China.
Zhang T; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China; Shenzhen Research Institute of Nanjing University, Shenzhen, 518057, China.
Zhang Y; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.
Zhang X; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.
Liu X; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.
Tie Z; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.
Dou Y; Department of Chemical Engineering and Food Processing, Xuancheng Campus, Hefei University of Technology, Xuancheng, 242000 Anhui, China.
Lu Z; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China. Electronic address: .
Hu Y; College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China; Shenzhen Research Institute of Nanjing University, Shenzhen, 518057, China. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Feb; Vol. 186, pp. 110727. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Gold/*pharmacology
Metal Nanoparticles/*chemistry
Silver/*pharmacology
Staphylococcus aureus/*drug effects
Animals ; Anti-Bacterial Agents/chemistry ; Cell Survival/drug effects ; Female ; Gold/chemistry ; Hep G2 Cells ; Humans ; Microbial Sensitivity Tests ; Particle Size ; Porosity ; Rats ; Rats, Mutant Strains ; Silver/chemistry ; Surface Properties ; Wound Healing/drug effects
Czasopismo naukowe
Tytuł :
Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca channel.
Autorzy :
Kuramoto T; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan. Electronic address: .
Yokoe M; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Kunisawa N; Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, 569-1094, Japan.
Ohashi K; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Miyake T; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Higuchi Y; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Yoshimi K; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Mashimo T; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Tanaka M; Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka, 598-8531, Japan.
Kuwamura M; Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka, 598-8531, Japan.
Kaneko S; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Shimizu S; Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, 569-1094, Japan.
Serikawa T; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan; Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, 569-1094, Japan.
Ohno Y; Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, 569-1094, Japan.
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Źródło :
Brain research [Brain Res] 2017 Dec 01; Vol. 1676, pp. 38-45. Date of Electronic Publication: 2017 Sep 13.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Mutation, Missense*
Rats, Inbred F344*
Rats, Mutant Strains*
Small-Conductance Calcium-Activated Potassium Channels/*genetics
Tremor/*genetics
Animals ; Anti-Dyskinesia Agents/pharmacology ; Brain/metabolism ; Brain/pathology ; Chromosome Mapping ; Disease Models, Animal ; Essential Tremor/drug therapy ; Essential Tremor/genetics ; Essential Tremor/metabolism ; Essential Tremor/pathology ; HEK293 Cells ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Patch-Clamp Techniques ; Phenotype ; Small-Conductance Calcium-Activated Potassium Channels/metabolism ; Transfection ; Tremor/drug therapy ; Tremor/metabolism ; Tremor/pathology
Czasopismo naukowe
Tytuł :
The Quinpirole Hypolocomotive Effects are Strain and Route of Administration Dependent in SHR and SLA16 Isogenic Rats.
Autorzy :
Pértile RAN; Laboratory of Behavior Genetics, Department of Cellular Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil.; Queensland Brain Institute, University of Queensland, Brisbane, QLD, 4072, Australia.
Corvino ME; Laboratory of Behavior Genetics, Department of Cellular Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil.
Marchette RCN; Laboratory of Behavior Genetics, Department of Cellular Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil.; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil.
Pavesi E; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil.
Cavalli J; Laboratory of Behavior Genetics, Department of Cellular Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil.
Ramos A; Laboratory of Behavior Genetics, Department of Cellular Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil.
Izídio GS; Laboratory of Behavior Genetics, Department of Cellular Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil. .; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil. .
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Źródło :
Behavior genetics [Behav Genet] 2017 Sep; Vol. 47 (5), pp. 552-563. Date of Electronic Publication: 2017 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Behavior, Animal/*drug effects
Locomotion/*drug effects
Rats, Mutant Strains/*metabolism
Animals ; Anxiety ; Dopamine/metabolism ; Dopamine D2 Receptor Antagonists/metabolism ; Drug Administration Routes ; Haloperidol/pharmacology ; Hippocampus/drug effects ; Male ; Motor Activity/physiology ; Quinpirole/metabolism ; Quinpirole/pharmacology ; Rats ; Rats, Inbred SHR/genetics ; Rats, Inbred SHR/metabolism ; Rats, Mutant Strains/genetics ; Receptors, Dopamine D2/drug effects ; Receptors, Dopamine D2/metabolism
Czasopismo naukowe
Tytuł :
An Overview of Rodent Models of Obesity and Type 2 Diabetes.
Autorzy :
Lutz TA; Institute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2128, pp. 11-24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*genetics
Diabetes Mellitus, Type 2/*metabolism
Obesity/*genetics
Obesity/*metabolism
Animals ; Animals, Genetically Modified ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diet/adverse effects ; Disease Models, Animal ; Leptin/genetics ; Leptin/metabolism ; Mice ; Mice, Mutant Strains/metabolism ; Rats ; Rats, Mutant Strains/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA-24 protects retina from degeneration in rats by down-regulating chitinase-3-like protein 1.
Autorzy :
Lian C; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Lou H; Department of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Zhang J; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tian H; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Ou Q; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Xu JY; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Jin C; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Gao F; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Zhang J; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Wang J; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.
Li W; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China; Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, 19129, USA.
Xu G; Department of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. Electronic address: .
Lu L; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China. Electronic address: .
Xu GT; Department of Ophthalmology of Shanghai Tenth People's Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200092, China; Laboratory of Clinical Visual Science, Department of Regenerative Medicine, and Stem Cell Research Center, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China; Collaborative Innovation Center for Brain Science, Tongji University, Shanghai, 200092, China. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2019 Nov; Vol. 188, pp. 107791. Date of Electronic Publication: 2019 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chitinase-3-Like Protein 1/*metabolism
MicroRNAs/*physiology
Retina/*metabolism
Retinal Degeneration/*prevention & control
Retinal Pigment Epithelium/*metabolism
Animals ; Autophagy ; Blotting, Western ; Cell Line ; Disease Models, Animal ; Down-Regulation ; Electroretinography ; In Situ Nick-End Labeling ; Male ; Microscopy, Electron, Transmission ; Rats ; Rats, Mutant Strains ; Rats, Sprague-Dawley ; Retina/physiopathology ; Retinal Degeneration/enzymology ; Retinal Degeneration/physiopathology ; Retinal Pigment Epithelium/physiopathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9 system.
Autorzy :
Goto T; Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Hara H; Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan.
Nakauchi H; Japan Science Technology Agency, ERATO, Nakauchi Stem Cell and Organ Regeneration Project, Minato-ku, Tokyo, Japan.; The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
Hochi S; Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano, Japan.
Hirabayashi M; Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi, 444-8787, Japan. .
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Źródło :
Transgenic research [Transgenic Res] 2016 Aug; Vol. 25 (4), pp. 533-44. Date of Electronic Publication: 2016 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Rats, Mutant Strains*
Forkhead Transcription Factors/*genetics
Thymus Gland/*physiopathology
Animals ; Female ; Forkhead Transcription Factors/metabolism ; Homozygote ; Male ; Phenotype ; Rats, Wistar ; T-Lymphocytes/physiology
Czasopismo naukowe
Tytuł :
SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis.
Autorzy :
Jing Y; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
Zhou Y; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
Zhou F; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
Wang X; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
Tao B; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
Sun L; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
Liu J; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
Zhao H; Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
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Źródło :
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2019 Sep 30; Vol. 65 (7), pp. 66-71. Date of Electronic Publication: 2019 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Osteogenesis/*physiology
Osteoporosis/*metabolism
Osteoporosis/*prevention & control
Sirtuin 2/*deficiency
Animals ; Blotting, Western ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cell Survival/genetics ; Cell Survival/physiology ; Female ; Osteoclasts/cytology ; Osteoclasts/metabolism ; Osteogenesis/genetics ; Osteoporosis/genetics ; Rats ; Rats, Mutant Strains ; Sirtuin 2/genetics
Czasopismo naukowe
Tytuł :
Oncolytic Activity of the Vaccine Strain of Type 3 Poliovirus on the Model of Rat Glioma C6 Cells.
Autorzy :
Sosnovtseva AO; V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia. .; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, Russia. .
Zheltukhin AO; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, Russia.
Lipatova AV; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, Russia.
Chumakov PM; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, Russia.; M. P. Chumakov Federal Research Center for Research and Development of Immunobiological Products, Russian Academy of Sciences, Moscow, Russia.
Chekhonin VP; V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
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Źródło :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 May; Vol. 167 (1), pp. 111-115. Date of Electronic Publication: 2019 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Glioma/*therapy
Glioma/*virology
Oncolytic Virotherapy/*methods
Poliovirus/*physiology
Animals ; Cell Line, Tumor ; Glioma/metabolism ; Interferon-alpha/genetics ; Interferon-beta/genetics ; Mice ; Oncolytic Viruses/physiology ; Rats ; Rats, Mutant Strains ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/metabolism
Czasopismo naukowe
Tytuł :
Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts.
Autorzy :
Wang H; From the Section of Hematology/Oncology and.
Lu J; From the Section of Hematology/Oncology and.
Kulkarni S; From the Section of Hematology/Oncology and.
Zhang W; From the Section of Hematology/Oncology and.
Gorka JE; From the Section of Hematology/Oncology and.
Mandel JA; From the Section of Hematology/Oncology and.
Goetzman ES; Division of Medical Genetics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224.
Prochownik EV; From the Section of Hematology/Oncology and .; the Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.; the The Hillman Cancer Center of UPMC, Pittsburgh, Pennsylvania 15232.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Apr 05; Vol. 294 (14), pp. 5466-5486. Date of Electronic Publication: 2019 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Citric Acid Cycle*
Membrane Potential, Mitochondrial*
Oxygen Consumption*
Fibroblasts/*metabolism
Pyruvate Dehydrogenase Complex/*genetics
Animals ; Cell Line, Tumor ; Cell Proliferation ; Fibroblasts/pathology ; Humans ; Pyruvate Dehydrogenase Complex/metabolism ; Rats ; Rats, Mutant Strains
Czasopismo naukowe
Tytuł :
Active caspase-3 upregulation is augmented in at-risk cerebellar Purkinje cells following inferior olive chemoablation in the shaker mutant rat: an immunofluorescence study.
Autorzy :
Erekat NS; a Department of Anatomy, Faculty of Medicine , Jordan University of Science and Technology (JUST) , Irbid , Jordan.
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Źródło :
Neurological research [Neurol Res] 2019 Mar; Vol. 41 (3), pp. 234-241. Date of Electronic Publication: 2018 Nov 21.
Typ publikacji :
Journal Article
MeSH Terms :
Caspase 3/*metabolism
Cerebellar Vermis/*enzymology
Neurodegenerative Diseases/*metabolism
Olivary Nucleus/*physiopathology
Purkinje Cells/*enzymology
Animals ; Cerebellar Vermis/pathology ; Disease Models, Animal ; Gene Expression Regulation ; Neurodegenerative Diseases/pathology ; Purkinje Cells/pathology ; Random Allocation ; Rats, Mutant Strains
Czasopismo naukowe
Tytuł :
Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.
Autorzy :
Hautefort A; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Mendes-Ferreira P; Department of Surgery and Physiology, Faculty of Medicine, UnICCardiovascular Research and Development Centre, University of Porto, Portugal (P.M.-F., R.A., C.B.-S.).; Respiratory Division, Department of Department of Chronic Diseases, Metabolism & Aging, KU Leuven-University of Leuven, Belgium (P.M.-F.).
Sabourin J; Signalisation et Physiopathologie Cardiovasculaire, UMR-S 1180, Université Paris-Sud, INSERM, Université Paris-Saclay, 92296, Châtenay-Malabry, France (J.S., B.M., A.M.G.).
Manaud G; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Bertero T; Université Côte d'Azur, CNRS, IRCAN, Nice, France (T.B.).
Rucker-Martin C; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Riou M; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Adão R; Department of Surgery and Physiology, Faculty of Medicine, UnICCardiovascular Research and Development Centre, University of Porto, Portugal (P.M.-F., R.A., C.B.-S.).
Manoury B; Signalisation et Physiopathologie Cardiovasculaire, UMR-S 1180, Université Paris-Sud, INSERM, Université Paris-Saclay, 92296, Châtenay-Malabry, France (J.S., B.M., A.M.G.).
Lambert M; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Boet A; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Lecerf F; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Domergue V; Animal Facility, Institut Paris Saclay d'Innovation Thérapeutique (UMS IPSIT), Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France (V.D.).
Brás-Silva C; Department of Surgery and Physiology, Faculty of Medicine, UnICCardiovascular Research and Development Centre, University of Porto, Portugal (P.M.-F., R.A., C.B.-S.).
Gomez AM; Signalisation et Physiopathologie Cardiovasculaire, UMR-S 1180, Université Paris-Sud, INSERM, Université Paris-Saclay, 92296, Châtenay-Malabry, France (J.S., B.M., A.M.G.).
Montani D; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Girerd B; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Humbert M; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Antigny F; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).
Perros F; Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie et Réanimation Respiratoire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; UMRS 999, INSERM and Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (A.H., G.M., C.R.-M., M.R., M.L., A.B., F.L., D.M., B.G., M.H., F.A., F.P.).; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, QC, Canada (F.P.).
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Źródło :
Circulation [Circulation] 2019 Feb 12; Vol. 139 (7), pp. 932-948.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Arterial Pressure/*genetics
Bone Morphogenetic Protein Receptors, Type II/*genetics
Hypertension, Pulmonary/*genetics
Hypertension, Pulmonary/*physiopathology
Myocardial Contraction/*genetics
Pulmonary Artery/*physiopathology
Ventricular Function, Right/*genetics
Action Potentials ; Animals ; Bone Morphogenetic Protein Receptors, Type II/metabolism ; Calcium Signaling ; Disease Models, Animal ; Genetic Predisposition to Disease ; Hypertension, Pulmonary/metabolism ; Hypoxia/complications ; Myocytes, Cardiac/metabolism ; Nerve Tissue Proteins/metabolism ; Phenotype ; Phosphorylation ; Potassium Channels, Tandem Pore Domain/metabolism ; Pulmonary Artery/metabolism ; Rats, Mutant Strains ; Smad Proteins/metabolism
Czasopismo naukowe
Tytuł :
Retinal Deficits Precede Cognitive and Motor Deficits in a Rat Model of Type II Diabetes.
Autorzy :
Allen RS; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.
Feola A; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.
Motz CT; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.
Ottensmeyer AL; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.; Department of Ophthalmology, Emory University, Atlanta, Georgia, United States.
Chesler KC; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.
Dunn R; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.
Thulé PM; Section Endocrinology & Metabolism, Atlanta VA Health Care System & Emory University School of Medicine, Decatur, Georgia, United States.
Pardue MT; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2019 Jan 02; Vol. 60 (1), pp. 123-133.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Disease Models, Animal*
Cognition Disorders/*diagnosis
Diabetes Mellitus, Type 2/*diagnosis
Diabetic Retinopathy/*diagnosis
Motor Disorders/*diagnosis
Animals ; Blood Glucose/metabolism ; Cognition Disorders/physiopathology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Retinopathy/physiopathology ; Electroretinography ; Exploratory Behavior/physiology ; Female ; Glucose Tolerance Test ; Hyperglycemia/diagnosis ; Hyperglycemia/physiopathology ; Male ; Motor Disorders/physiopathology ; Rats ; Rats, Mutant Strains ; Rats, Wistar ; Retina/physiopathology ; Tomography, Optical Coherence
Czasopismo naukowe
Tytuł :
Evaluation of visual function in Royal College of Surgeon rats using a depth perception visual cliff test.
Autorzy :
Tzameret A; Goldschleger Eye Research Institute, Sheba Medical Center, Tel HaShomer, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sher I; Goldschleger Eye Institute, Sheba Medical Center, Tel HaShomer, Israel.
Edelstain V; Goldschleger Eye Institute, Sheba Medical Center, Tel HaShomer, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Belkin M; Goldschleger Eye Research Institute, Sheba Medical Center, Tel HaShomer, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Kalter-Leibovici O; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Unit of Cardiovascular Epidemiology, Gertner Institute for Epidemiology and Health Policy Research, Ramat Gan, Israel.
Solomon AS; Goldschleger Eye Research Institute, Sheba Medical Center, Tel HaShomer, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Rotenstreich Y; Goldschleger Eye Institute, Sheba Medical Center, Tel HaShomer, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Źródło :
Visual neuroscience [Vis Neurosci] 2019 Jan; Vol. 36, pp. E002.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depth Perception/*physiology
Retina/*physiopathology
Retinal Degeneration/*physiopathology
Visual Acuity/*physiology
Aging/physiology ; Animals ; Cone Opsins/metabolism ; Electroretinography ; Microscopy, Fluorescence ; Rats ; Rats, Long-Evans ; Rats, Mutant Strains ; Retina/metabolism ; Retinal Degeneration/metabolism ; Rhodopsin/metabolism ; Vision Tests
Czasopismo naukowe
Tytuł :
Letter to the editor announcing the availability of RCS and transgenic rats with P23H and S334ter rhodopsin mutations with inherited retinal degenerations.
Autorzy :
Bryda EC; Department of Veterinary Pathobiology and RRRC, University of Missouri, Columbia, MO, 65201, USA.
LaVail MM; Beckman Vision Center, UCSF School of Medicine, San Francisco, CA, 94143-0730, USA. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2019 Jan; Vol. 178, pp. 176. Date of Electronic Publication: 2018 Oct 06.
Typ publikacji :
Letter
MeSH Terms :
Disease Models, Animal*
Retinal Degeneration/*genetics
Rhodopsin/*genetics
Animals ; Rats ; Rats, Mutant Strains ; Rats, Transgenic
Opinia redakcyjna

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