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Tytuł :
Renovascular hypertension elevates pulmonary ventilation in rats by carotid body-dependent mechanisms.
Autorzy :
Melo MR; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Gasparini S; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Silva EF; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.; Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
Karlen-Amarante M; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Speretta GF; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Lauar MR; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Pedrino GR; Center for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
Menani JV; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Colombari DSA; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Zoccal DB; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Colombari E; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Apr 01; Vol. 318 (4), pp. R730-R742. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Rats, Sprague-Dawley*
Carotid Body/*physiology
Hypertension, Renovascular/*physiopathology
Angiotensin II/administration & dosage ; Angiotensin II/pharmacology ; Animals ; Hypoglossal Nerve/physiology ; Male ; Phenylephrine/administration & dosage ; Phenylephrine/pharmacology ; Phrenic Nerve/physiology ; Rats ; Sympathetic Nervous System ; Sympathomimetics/pharmacology
Czasopismo naukowe
Tytuł :
An immunocompetent rat model of infection with Cryptosporidium hominis and Cryptosporidium parvum.
Autorzy :
Dayao DA; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, USA.
Sheoran A; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, USA.
Carvalho A; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, USA.
Xu H; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, USA.
Beamer G; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, USA.
Widmer G; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, USA.
Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, USA. Electronic address: .
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Źródło :
International journal for parasitology [Int J Parasitol] 2020 Jan; Vol. 50 (1), pp. 19-22. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Models, Animal*
Antibodies, Protozoan/*biosynthesis
Cryptosporidium/*immunology
Cryptosporidium parvum/*immunology
Rats, Sprague-Dawley/*immunology
Animals ; Antigens, Protozoan ; Cryptosporidiosis/prevention & control ; Female ; Immunity, Humoral ; Immunocompetence ; Rats ; Rats, Sprague-Dawley/parasitology ; Sporozoites/immunology ; Trachea/parasitology ; Vaccination/methods
Czasopismo naukowe
Tytuł :
[Influence of oxidative/antioxidative biomarkers and inflammatory cytokines on rats after sub-acute orally administration of titanium dioxide nanoparticles].
Autorzy :
Zhou D
Chen ZJ
Hu GP
Yan TL
Long CM
Feng HM
Jia G
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Źródło :
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2020 Oct 18; Vol. 52 (5), pp. 821-827.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants*
Nanoparticles*
Animals ; Biomarkers ; Cytokines ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley ; Titanium
Czasopismo naukowe
Tytuł :
Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway.
Autorzy :
Sun RX; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Sun ZH; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Ren Q; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Li L; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Yin L; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Li F; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Su X; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Dec 30; Vol. 763, pp. 145030. Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*
Cell Cycle Proteins/*metabolism
Ocular Hypertension/*metabolism
Retinal Ganglion Cells/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Apoptosis ; Cell Cycle Proteins/genetics ; Cells, Cultured ; Humans ; Male ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in CCI rat models.
Autorzy :
Li L; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Luo Y; Department of Thoracic Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhang Y; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Wei M; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhang M; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Liu H; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Su Z; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Dec 30; Vol. 763, pp. 145069. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs/*metabolism
Neuralgia/*metabolism
Phosphopyruvate Hydratase/*genetics
RNA, Circular/*metabolism
Animals ; Cells, Cultured ; HEK293 Cells ; Humans ; Male ; MicroRNAs/genetics ; Neuralgia/genetics ; Phosphopyruvate Hydratase/metabolism ; RNA, Circular/genetics ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Novel molecular mechanisms underlying the ameliorative effect of N-acetyl-L-cysteine against ϒ-radiation-induced premature ovarian failure in rats.
Autorzy :
Mantawy EM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Said RS; Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt. Electronic address: .
Kassem DH; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Badr AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 15; Vol. 206, pp. 111190. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcysteine/*pharmacology
Gamma Rays/*adverse effects
Ovary/*drug effects
Primary Ovarian Insufficiency/*prevention & control
Radiation-Protective Agents/*pharmacology
Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/metabolism ; Disease Models, Animal ; Female ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/radiation effects ; NADPH Oxidase 4/metabolism ; Ovary/metabolism ; Ovary/radiation effects ; Ovary/ultrastructure ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Primary Ovarian Insufficiency/etiology ; Primary Ovarian Insufficiency/metabolism ; Primary Ovarian Insufficiency/pathology ; Rats ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling.
Autorzy :
Chen M; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Zhao S; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Guo WH; Pathology Center, Shanghai General Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Zhu YP; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Pan L; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Xie ZW; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Sun WL; Department of Geriatrics, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China. Electronic address: .
Jiang JT; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111154. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*chemically induced
Diabetes, Gestational/*chemically induced
Dibutyl Phthalate/*toxicity
Endocrine Disruptors/*toxicity
Forkhead Box Protein M1/*metabolism
Maternal Exposure/*adverse effects
STAT1 Transcription Factor/*metabolism
Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/metabolism ; Diabetes, Gestational/metabolism ; Female ; Forkhead Box Protein M1/genetics ; Gene Expression/drug effects ; Humans ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Phosphorylation ; Pregnancy ; Primary Cell Culture ; Rats ; Rats, Sprague-Dawley ; STAT1 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway.
Autorzy :
Cuiqiong W; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
Chao X; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
Xinling F; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
Yinyan J; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 473-478.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Carbon Tetrachloride Poisoning*/drug therapy
Carbon Tetrachloride Poisoning*/metabolism
Carbon Tetrachloride Poisoning*/pathology
Liver Cirrhosis*/chemically induced
Liver Cirrhosis*/drug therapy
Liver Cirrhosis*/metabolism
Liver Cirrhosis*/pathology
Lignans/*pharmacology
MicroRNAs/*metabolism
Polycyclic Compounds/*pharmacology
Signal Transduction/*drug effects
Transforming Growth Factor beta/*metabolism
Animals ; Cyclooctanes/pharmacology ; Humans ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
New application for assessment of dry eye syndrome induced by particulate matter exposure.
Autorzy :
Song SJ; Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.
Hyun SW; Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.
Lee TG; Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.
Park B; Non-clinical Research Collaboration Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.
Jo K; Non-clinical Research Collaboration Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.
Kim CS; Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea; Korean Convergence Medicine, University of Science and Technology (UST), Daejeon, 34054, Republic of Korea. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111125. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Air Pollutants/*toxicity
Conjunctiva/*drug effects
Cornea/*drug effects
Dry Eye Syndromes/*chemically induced
Particulate Matter/*toxicity
Aerosols ; Air Pollutants/analysis ; Animals ; Conjunctiva/metabolism ; Cornea/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Dry Eye Syndromes/metabolism ; Female ; Humans ; Mucin-4/metabolism ; Particle Size ; Particulate Matter/analysis ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism.
Autorzy :
Xing H; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Luo X; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Li Y; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Fan C; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Liu N; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Cui C; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Li W; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 152-156.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacokinetics
Calcium Channel Blockers/*pharmacology
Camptothecin/*analogs & derivatives
Verapamil/*pharmacology
Administration, Oral ; Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Biological Availability ; Biological Transport ; Caco-2 Cells ; Calcium Channel Blockers/administration & dosage ; Camptothecin/administration & dosage ; Camptothecin/pharmacokinetics ; Drug Interactions ; Humans ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Rats ; Rats, Sprague-Dawley ; Verapamil/administration & dosage
Czasopismo naukowe
Tytuł :
MiR-122-5p and miR-326-3p promote cadmium-induced NRK-52E cell apoptosis by downregulating PLD1.
Autorzy :
Yuan W; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Liang L; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Huang K; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Deng Y; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Dong M; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, China.
Wang G; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Zou F; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Dec; Vol. 35 (12), pp. 1334-1342. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cadmium/*toxicity
Epithelial Cells/*drug effects
MicroRNAs/*genetics
Phospholipase D/*genetics
3' Untranslated Regions ; Animals ; Apoptosis/genetics ; Cell Line ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Dose-Response Relationship, Drug ; Down-Regulation ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Gene Expression Regulation/drug effects ; Humans ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Synthesis, activity and mechanism of alkoxy-, carbamato-, sulfonamido-, thioureido-, and ureido-derivatives of 2,4,5-trimethylpyridin-3-ol against inflammatory bowel disease.
Autorzy :
Chaudhary CL; College of Pharmacy and Institute for Drug Research, Yeungnam University , Gyeongsan , Republic of Korea.
Gurung P; College of Pharmacy and Institute for Drug Research, Yeungnam University , Gyeongsan , Republic of Korea.
Jang S; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , Republic of Korea.
Banskota S; College of Pharmacy and Institute for Drug Research, Yeungnam University , Gyeongsan , Republic of Korea.
Nam TG; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , Republic of Korea.
Kim JA; College of Pharmacy and Institute for Drug Research, Yeungnam University , Gyeongsan , Republic of Korea.
Jeong BS; College of Pharmacy and Institute for Drug Research, Yeungnam University , Gyeongsan , Republic of Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1-20.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Inflammatory Bowel Diseases/*drug therapy
Pyridines/*pharmacology
Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Cells, Cultured ; Colitis/chemically induced ; Colitis/drug therapy ; Cytokines/antagonists & inhibitors ; Cytokines/metabolism ; Dose-Response Relationship, Drug ; Female ; HT29 Cells ; Humans ; Inflammatory Bowel Diseases/pathology ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Trinitrobenzenesulfonic Acid ; U937 Cells
Czasopismo naukowe
Tytuł :
Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.
Autorzy :
Ren Z; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P. R. China, Zhengzhou, China.
Li J; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P. R. China, Zhengzhou, China.
Shen J; First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Yu H; First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Mei X; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
Zhao P; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P. R. China, Zhengzhou, China.
Xiao Z; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
Wu W; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 116-123.
Typ publikacji :
Journal Article
MeSH Terms :
Pneumonia, Bacterial/*drug therapy
Pulmonary Disease, Chronic Obstructive/*drug therapy
Sildenafil Citrate/*pharmacology
Smoke/*adverse effects
Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Klebsiella Infections/drug therapy ; Klebsiella pneumoniae/isolation & purification ; Lung/drug effects ; Lung/physiopathology ; Phosphodiesterase 5 Inhibitors/administration & dosage ; Phosphodiesterase 5 Inhibitors/pharmacology ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/pathology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Rats ; Rats, Sprague-Dawley ; Sildenafil Citrate/administration & dosage ; Tobacco/adverse effects
Czasopismo naukowe
Tytuł :
Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress.
Autorzy :
Berk A; Department of Pharmacy, Elazığ Fethi Sekin City Hospital, Elazığ, Turkey.
Yılmaz İ; Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Turkey.
Abacıoğlu N; Department of Pharmacology, Faculty of Pharmacy, Near East University, Mersin, Turkey.
Kaymaz MB; Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Turkey.
Karaaslan MG; Department of Chemistry, Faculty of Art and Science, Inonu University, Malatya, Turkey.
Kuyumcu Savan E; Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, İnönü University, Malatya, Turkey.
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Źródło :
The Libyan journal of medicine [Libyan J Med] 2020 Dec; Vol. 15 (1), pp. 1725991.
Typ publikacji :
Journal Article
MeSH Terms :
Depression/*drug therapy
Gentiana/*adverse effects
Medicine, Traditional/*adverse effects
Plant Extracts/*pharmacology
Stress, Psychological/*drug therapy
Animals ; Antidepressive Agents, Tricyclic/pharmacology ; Antioxidants/pharmacology ; Case-Control Studies ; Corticosterone/blood ; Cytokines/blood ; Cytokines/drug effects ; Hippocampus/drug effects ; Humans ; Imipramine/pharmacology ; Liver/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/drug effects
Czasopismo naukowe
Tytuł :
A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats.
Autorzy :
Chen Y; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, and Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University, Xi'an, China; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
Zong C; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, and Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University, Xi'an, China; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
Jia J; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
Liu Y; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, and Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
Zhang Z; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
Cai B; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, and Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University, Xi'an, China; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
Tian L; State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, and Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University, Xi'an, China. Electronic address: .
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Źródło :
International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2020 Dec; Vol. 49 (12), pp. 1648-1654. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells*
Osteoradionecrosis*/prevention & control
Animals ; Bone Marrow Cells ; Hydrogen ; Rats ; Rats, Sprague-Dawley ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
Apigenin-7- O -β-d-(6″- p -coumaroyl)-glucopyranoside reduces myocardial ischaemia/reperfusion injury in an experimental model via regulating the inflammation response.
Autorzy :
Quan W; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an, China.; Xi'an Mental Health Center, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
Ma S; Department of Pharmacy, Xijing Hospital, Air Force Medical University, Xi'an, China.
Zhu Y; Department of Pharmacy, Xijing Hospital, Air Force Medical University, Xi'an, China.
Shao Q; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an, China.; Xi'an Mental Health Center, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
Hou J; Xi'an Mental Health Center, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
Li X; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an, China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 80-88.
Typ publikacji :
Journal Article
MeSH Terms :
Apigenin/*pharmacology
Cardiotonic Agents/*pharmacology
Glucosides/*pharmacology
Inflammation/*drug therapy
Myocardial Reperfusion Injury/*drug therapy
Animals ; Animals, Newborn ; Apigenin/isolation & purification ; Apoptosis/drug effects ; Cardiotonic Agents/isolation & purification ; Cell Survival/drug effects ; Clematis/chemistry ; Cytokines/metabolism ; Disease Models, Animal ; Glucosides/isolation & purification ; Inflammation/pathology ; Male ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/physiopathology ; Myocardial Reperfusion Injury/physiopathology ; Myocytes, Cardiac/drug effects ; NF-kappa B/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury.
Autorzy :
Kang J; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Zhang C; Department of Orthopedics, School of Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.
Zhi Z; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Wang Y; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Liu J; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Wu F; Shanghai Clinical Research Center for Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xu G; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 627-638.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes/*transplantation
MicroRNAs/*genetics
Spinal Cord Injuries/*therapy
Stem Cells/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 3/metabolism ; Cells, Cultured ; Culture Media, Conditioned/metabolism ; Culture Media, Conditioned/pharmacology ; Exosomes/genetics ; Exosomes/metabolism ; Gene Expression Regulation ; Humans ; Locomotion/physiology ; Male ; Neuroepithelial Cells/cytology ; Neuroepithelial Cells/metabolism ; Neurons/metabolism ; Neurons/pathology ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/physiopathology ; Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Nanocomplexes loaded with miR-128-3p for enhancing chemotherapy effect of colorectal cancer through dual-targeting silence the activity of PI3K/AKT and MEK/ERK pathway.
Autorzy :
Liu X; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Dong C; Department of the Second Medical Oncology, The 3rd Affiliated Hospital of Kunming Medical University, Yunnan Tumor Hospital, Kunming, China.
Ma S; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Wang Y; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Lin T; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Li Y; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Yang S; Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
Zhang W; Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
Zhang R; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Zhao G; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.; Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 323-333.
Typ publikacji :
Journal Article
MeSH Terms :
Nanoparticles*
Colorectal Neoplasms/*therapy
Fluorouracil/*pharmacology
MicroRNAs/*genetics
Animals ; Antimetabolites, Antineoplastic ; Colorectal Neoplasms/genetics ; Humans ; MAP Kinase Signaling System/genetics ; Male ; Methacrylates/chemistry ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nylons/chemistry ; Phosphatidylinositol 3-Kinase/metabolism ; Polyethylene Glycols/chemistry ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology.
Autorzy :
Hu B; College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, P, R. China.
Yan H; School of Mechanical Engineering, Hebei University of Science and Technology, Shijiazhuang, P. R. China.
Sun Y; College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, P, R. China.
Chen X; College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, P, R. China.
Sun Y; College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, P, R. China.
Li S; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Jing Y; College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, P, R. China.
Li H; School of Pharmacy, China Medical University, Shenyang, P. R. China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 266-275.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Liberation*
Amino Acids/*chemistry
Drug Carriers/*chemistry
Animals ; Gels ; Hydrophobic and Hydrophilic Interactions ; Male ; Rats ; Rats, Sprague-Dawley ; Rheology ; Risperidone/chemistry ; Risperidone/pharmacokinetics ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Effects of naringenin on the pharmacokinetics of tofacitinib in rats.
Autorzy :
Wang B; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Shen J; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Zhou Q; The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Meng D; School of Medicine, Yichun University, Yichun, China.
He Y; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Chen F; The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
Wang S; The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.; School of Pharmaceutical Science, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Ji W; Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 225-230.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacokinetics
Anti-Inflammatory Agents/*pharmacology
Flavanones/*pharmacology
Piperidines/*pharmacokinetics
Piperidines/*pharmacology
Pyrimidines/*pharmacokinetics
Pyrimidines/*pharmacology
Pyrroles/*pharmacokinetics
Pyrroles/*pharmacology
Administration, Oral ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Area Under Curve ; Arthritis, Rheumatoid/drug therapy ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Flavanones/administration & dosage ; Piperidines/administration & dosage ; Piperidines/blood ; Pyrimidines/administration & dosage ; Pyrimidines/blood ; Pyrroles/administration & dosage ; Pyrroles/blood ; Rats, Sprague-Dawley ; Signal-To-Noise Ratio
Czasopismo naukowe

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