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    Tytuł:
    Cross-species comparative analysis of single presynapses.
    Autorzy:
    Berson E; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    Gajera CR; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
    Phongpreecha T; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    Perna A; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
    Bukhari SA; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
    Becker M; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    Chang AL; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    De Francesco D; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    Espinosa C; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    Ravindra NG; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    Postupna N; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
    Latimer CS; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
    Shively CA; Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Register TC; Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Craft S; Department of Internal Medicine-Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Montine KS; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
    Fox EJ; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
    Keene CD; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
    Bendall SC; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
    Aghaeepour N; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
    Montine TJ; Department of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2023 Aug 24; Vol. 13 (1), pp. 13849. Date of Electronic Publication: 2023 Aug 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
    MeSH Terms:
    Synaptic Transmission*
    Brain*
    Humans ; Animals ; Mice ; Cerebral Cortex ; Lipid Metabolism ; Macaca
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization.
    Autorzy:
    Schultz B; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Zaliani A; ScreeningPort, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune Mediated Diseases, CIMD, External Partner Site, 22525, Hamburg, Germany.
    Ebeling C; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Reinshagen J; ScreeningPort, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune Mediated Diseases, CIMD, External Partner Site, 22525, Hamburg, Germany.
    Bojkova D; Institute for Medical Virology, University Hospital Frankfurt, 60590, Frankfurt am Main, Germany.
    Lage-Rupprecht V; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Karki R; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Lukassen S; Center for Digital Health, Berlin Institute of Health (BIH), Charité Universitätsmedizin Berlin, Berlin, Germany.
    Gadiya Y; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Ravindra NG; Center for Biomedical Data Science, Yale School of Medicine, Yale University, 333 Cedar Street, New Haven, CT, 06510, USA.
    Das S; Unit 8B Bankside, PrecisionLife Ltd., Hanborough Business Park, Long Hanborough, Oxfordshire, OX29 8LJ, UK.
    Baksi S; Causality BioModels Pvt Ltd., Kinfra Hi-Tech Park, Kerala Technology Innovation Zone- KTIZ, Kalamassery, Cochin, 683503, India.
    Domingo-Fernández D; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Lentzen M; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Strivens M; Unit 8B Bankside, PrecisionLife Ltd., Hanborough Business Park, Long Hanborough, Oxfordshire, OX29 8LJ, UK.
    Raschka T; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Cinatl J; Institute for Medical Virology, University Hospital Frankfurt, 60590, Frankfurt am Main, Germany.
    DeLong LN; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Gribbon P; ScreeningPort, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune Mediated Diseases, CIMD, External Partner Site, 22525, Hamburg, Germany.
    Geisslinger G; Fraunhofer Cluster of Excellence for Immune Mediated Diseases, CIMD, External Partner Site, 22525, Hamburg, Germany.; Pharmazentrum Frankfurt/ZAFES, Institut Für Klinische Pharmakologie, Klinikum Der Goethe-Universität Frankfurt, 60590, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596, Frankfurt am Main, Germany.
    Ciesek S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596, Frankfurt am Main, Germany.; Institute for Medical Virology, University Hospital Frankfurt, 60590, Frankfurt am Main, Germany.; DZIF, German Centre for Infection Research, External Partner Site, 60596, Frankfurt am Main, Germany.
    van Dijk D; Center for Biomedical Data Science, Yale School of Medicine, Yale University, 333 Cedar Street, New Haven, CT, 06510, USA.
    Gardner S; Unit 8B Bankside, PrecisionLife Ltd., Hanborough Business Park, Long Hanborough, Oxfordshire, OX29 8LJ, UK.
    Kodamullil AT; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Fröhlich H; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Peitsch M; Philipp Morris International R&D, Biological Systems Research, R&D Innovation Cube T1517.07, Quai Jeanrenaud 5, 2000, Neuchâte, Switzerland.
    Jacobs M; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany.
    Hoeng J; Philipp Morris International R&D, Biological Systems Research, R&D Innovation Cube T1517.07, Quai Jeanrenaud 5, 2000, Neuchâte, Switzerland.
    Eils R; Center for Digital Health, Berlin Institute of Health (BIH), Charité Universitätsmedizin Berlin, Berlin, Germany.
    Claussen C; ScreeningPort, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune Mediated Diseases, CIMD, External Partner Site, 22525, Hamburg, Germany.
    Hofmann-Apitius M; Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Department of Bioinformatics, Institutszentrum Birlinghoven, 53754, Sankt Augustin, Germany. .
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    Źródło:
    Scientific reports [Sci Rep] 2021 May 26; Vol. 11 (1), pp. 11049. Date of Electronic Publication: 2021 May 26.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    COVID-19 Drug Treatment*
    Antiviral Agents/*therapeutic use
    Drug Repositioning/*methods
    SARS-CoV-2/*physiology
    Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Combined Modality Therapy ; Computational Biology ; Drug Synergism ; Drug Therapy, Combination ; GTP Phosphohydrolases/therapeutic use ; Humans ; Knowledge Bases ; Nelfinavir/therapeutic use ; Pandemics ; Raloxifene Hydrochloride/therapeutic use
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.
    Autorzy:
    Ravindra NG; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.
    Alfajaro MM; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
    Gasque V; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.; Universite Claude Bernard Lyon 1, Faculte de Medecine Lyon Est, Lyon, France.; Department de Bioinformatique, Univ Evry, Universite Paris-Saclay, Paris, France.
    Huston NC; Department of Molecular Biophysics & Biochemistry, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Wan H; Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Szigeti-Buck K; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America.
    Yasumoto Y; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America.
    Greaney AM; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America.
    Habet V; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Chow RD; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Chen JS; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
    Wei J; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
    Filler RB; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
    Wang B; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
    Wang G; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Niklason LE; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America.; Department of Anesthesiology, Yale University, New Haven, Connecticut, United States of America.
    Montgomery RR; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Eisenbarth SC; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
    Chen S; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Williams A; The Jackson Laboratory, Farmington, Connecticut, United States of America.
    Iwasaki A; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.
    Horvath TL; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America.
    Foxman EF; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
    Pierce RW; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America.
    Pyle AM; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.
    van Dijk D; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.
    Wilen CB; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
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    Źródło:
    PLoS biology [PLoS Biol] 2021 Mar 17; Vol. 19 (3), pp. e3001143. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression*
    Bronchi/*pathology
    COVID-19/*diagnosis
    SARS-CoV-2/*isolation & purification
    Single-Cell Analysis/*methods
    Adult ; Bronchi/virology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Cells, Cultured ; Epithelium/pathology ; Epithelium/virology ; Humans ; Immunity, Innate ; Longitudinal Studies ; SARS-CoV-2/genetics ; Transcriptome ; Viral Tropism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure.
    Autorzy:
    Mezzacappa C; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
    Ravindra NG; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
    Caraballo C; Center for Outcome Research & Evaluation (CORE), Yale University School of Medicine, New Haven, CT, United States of America.
    Chouairi F; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
    Miller PE; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
    Clarke JD; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
    Gruen J; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
    Mori M; Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, CT, United States of America.
    McCullough M; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
    Mullan C; Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, CT, United States of America.
    Geirsson A; Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, CT, United States of America.
    Rogers JG; Division of Cardiology, Duke University School of Medicine, Durham, NC, United States of America.
    Anwer M; Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, CT, United States of America.
    Desai N; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States of America.; Center for Outcome Research & Evaluation (CORE), Yale University School of Medicine, New Haven, CT, United States of America.
    Ahmad T; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
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    Źródło:
    PloS one [PLoS One] 2020 Dec 03; Vol. 15 (12), pp. e0242928. Date of Electronic Publication: 2020 Dec 03 (Print Publication: 2020).
    Typ publikacji:
    Comparative Study; Journal Article
    MeSH Terms:
    Clinical Trials as Topic*
    Heart-Assist Devices*
    Heart Failure/*therapy
    Aged ; Cohort Studies ; Disease Progression ; Female ; Heart Failure/pathology ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system.
    Autorzy:
    Caraballo C; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States of America.; Center for Outcomes Research & Evaluation (CORE), Yale New Haven Hospital, New Haven, CT, United States of America.
    McCullough M; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America.
    Fuery MA; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America.
    Chouairi F; Yale University School of Medicine, New Haven, CT, United States of America.
    Keating C; Joint Data Analytics Team, Yale New Haven Hospital, New Haven, CT, United States of America.
    Ravindra NG; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States of America.
    Miller PE; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States of America.
    Malinis M; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, United States of America.
    Kashyap N; Joint Data Analytics Team, Yale New Haven Hospital, New Haven, CT, United States of America.
    Hsiao A; Joint Data Analytics Team, Yale New Haven Hospital, New Haven, CT, United States of America.
    Wilson FP; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT, United States of America.
    Curtis JP; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States of America.; Center for Outcomes Research & Evaluation (CORE), Yale New Haven Hospital, New Haven, CT, United States of America.
    Grant M; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America.
    Velazquez EJ; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States of America.
    Desai NR; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States of America.; Center for Outcomes Research & Evaluation (CORE), Yale New Haven Hospital, New Haven, CT, United States of America.
    Ahmad T; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States of America.; Center for Outcomes Research & Evaluation (CORE), Yale New Haven Hospital, New Haven, CT, United States of America.
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    Źródło:
    PloS one [PLoS One] 2020 Sep 30; Vol. 15 (9), pp. e0238829. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Registries*
    Coronavirus Infections/*epidemiology
    Coronavirus Infections/*mortality
    Heart Failure/*epidemiology
    Pneumonia, Viral/*epidemiology
    Pneumonia, Viral/*mortality
    Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Cohort Studies ; Comorbidity ; Connecticut ; Delivery of Health Care, Integrated ; Female ; Heart Failure/mortality ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Pandemics ; Retrospective Studies ; SARS-CoV-2
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-5 z 5

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