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Wyszukujesz frazę ""Reactive oxygen species"" wg kryterium: Temat


Tytuł:
TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40.
Autorzy:
Ibraheem K; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
Yhmed AMA; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.; Department of Medical Laboratory Sciences, Faculty of Medical Technology, Wadi Alshatti University, Wadi Alshatti P.O. Box 68, Libya.
Nasef MM; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
Georgopoulos NT; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
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Źródło:
Cells [Cells] 2022 Oct 18; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
CD40 Antigens*/metabolism
Reactive Oxygen Species*/metabolism
TNF Receptor-Associated Factor 3*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/metabolism
p38 Mitogen-Activated Protein Kinases*/metabolism
MAP Kinase Kinase 4*
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
Humans ; Caspase 10/metabolism ; CD40 Ligand/metabolism ; MAP Kinase Kinase Kinase 5/metabolism ; NADPH Oxidases/metabolism ; BH3 Interacting Domain Death Agonist Protein/metabolism
Czasopismo naukowe
Tytuł:
Novel molecular photosensitizer with simultaneously GSH depletion, aggregation inhibition and accelerated elimination for improved and safe photodynamic therapy.
Autorzy:
Chen J; National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. Electronic address: .
Yan M; National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China.
Huang K; National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China.
Xue J; National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China.
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114938. Date of Electronic Publication: 2022 Nov 21.
Typ publikacji:
Journal Article
MeSH Terms:
Glutathione*/antagonists & inhibitors
Maleimides*/chemistry
Maleimides*/pharmacology
Photosensitizing Agents*/chemistry
Photosensitizing Agents*/pharmacology
Reactive Oxygen Species*/antagonists & inhibitors
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Photochemotherapy/methods ; Humans ; Hep G2 Cells
Czasopismo naukowe
Tytuł:
Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors.
Autorzy:
Zhou J; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Yu LZ; School of Pharmacy, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Fan YL; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Guo CH; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Lv XM; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Zhou ZY; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Huang HD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Miao DD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Zhang SP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Li XY; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
Zhao PP; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
Liu XP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
Hu WH; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
Zhang C; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114860. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase*/antagonists & inhibitors
Reactive Oxygen Species*
Thioredoxin Reductase 1*/antagonists & inhibitors
Colorectal Neoplasms*/enzymology
Cell Line, Tumor ; Humans ; Apoptosis/drug effects
Czasopismo naukowe
Tytuł:
An integrated approach to understand fluid shear stress-driven and reactive oxygen species-mediated metastasis of colon adenocarcinoma through mRNA-miRNA-lncRNA-circRNA networks.
Autorzy:
KrishnaPriya S; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras, Chennai, 600036, India.
Omer S; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras, Chennai, 600036, India.
Banerjee S; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras, Chennai, 600036, India. .; School of Bioscience and Technology, Vellore Institute of Technology, Vellore, India. .
Karunagaran D; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras, Chennai, 600036, India.
Suraishkumar GK; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras, Chennai, 600036, India.
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Źródło:
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2022 Sep; Vol. 297 (5), pp. 1353-1370. Date of Electronic Publication: 2022 Jul 13.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma*/genetics
Colonic Neoplasms*/genetics
Gene Regulatory Networks*/genetics
Reactive Oxygen Species*/metabolism
Shear Strength*/physiology
Humans ; MicroRNAs/genetics ; RNA, Circular/genetics ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; Stress, Physiological/physiology
Czasopismo naukowe
Tytuł:
Metformin-ROS-Nrf2 connection in the host defense mechanism against oxidative stress, apoptosis, cancers, and ageing.
Autorzy:
Udono H; Department of Immunology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Electronic address: .
Nishida M; Department of Immunology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
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Źródło:
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2022 Aug; Vol. 1866 (8), pp. 130171. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Metformin*/pharmacology
NF-E2-Related Factor 2*/immunology
NF-E2-Related Factor 2*/metabolism
Reactive Oxygen Species*/immunology
Reactive Oxygen Species*/metabolism
Apoptosis ; Humans ; Oxidative Stress/immunology
Czasopismo naukowe
Tytuł:
Promoting gene transfection by ROS responsive silicon nanowire arrays.
Autorzy:
Lu B; Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, Department of polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. .
Wang H; Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, Department of polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. .
Shen X; Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, Department of polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. .
Lu K; Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, Department of polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. .
Wang H; Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, Department of polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. .
Yuan L; Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, Department of polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. .
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Źródło:
Journal of materials chemistry. B [J Mater Chem B] 2022 Jul 13; Vol. 10 (27), pp. 5242-5250. Date of Electronic Publication: 2022 Jul 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Metal Nanoparticles*/chemistry
Nanowires*/chemistry
Reactive Oxygen Species*/chemistry
Reactive Oxygen Species*/pharmacology
Silicon*/chemistry
Transfection*/methods
Cell Line ; DNA/genetics ; Gold/chemistry ; Humans ; Plasmids/genetics
Czasopismo naukowe
Tytuł:
CORM-2 prevents human gingival fibroblasts from lipoteichoic acid-induced VCAM-1 and ICAM-1 expression by inhibiting TLR2/MyD88/TRAF6/PI3K/Akt/ROS/NF-κB signaling pathway.
Autorzy:
Cheng CY; Graduate Institute of Health Industry Technology, Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, No. 261, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan; Department of Pulmonary Infection and Immunology, Chang Gung Memorial Hospital at Linkou, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan.
Chen YH; Department of Orthopedic Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Thuy Tien Vo T; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Chui Hong Y; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Wang CS; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Canh Vo Q; Department of Dental Biomaterials Science, Dental Research Institute and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea.
Chou HC; Department of Chinese Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
Huang TW; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Lee IT; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: .
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Źródło:
Biochemical pharmacology [Biochem Pharmacol] 2022 Jul; Vol. 201, pp. 115099. Date of Electronic Publication: 2022 May 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
NF-kappa B*/metabolism
Organometallic Compounds*/pharmacology
Reactive Oxygen Species*/metabolism
TNF Receptor-Associated Factor 6*/metabolism
Toll-Like Receptor 2*/genetics
Toll-Like Receptor 2*/metabolism
Vascular Cell Adhesion Molecule-1*/genetics
Vascular Cell Adhesion Molecule-1*/metabolism
Fibroblasts ; Humans ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Lipopolysaccharides ; Myeloid Differentiation Factor 88/metabolism ; NADPH Oxidases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Teichoic Acids
Czasopismo naukowe
Tytuł:
A Kamm's Circle-Based Potential Risk Estimation Scheme in the Local Dynamic Map Computation Enhanced by Binary Decision Diagrams.
Autorzy:
Kumar A; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology (Kyutech), 2-4 Hibikino, Wakamatsu-Ku, Kitakyushu 808-0196, Japan.
Wagatsuma H; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology (Kyutech), 2-4 Hibikino, Wakamatsu-Ku, Kitakyushu 808-0196, Japan.
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Źródło:
Sensors (Basel, Switzerland) [Sensors (Basel)] 2022 Sep 24; Vol. 22 (19). Date of Electronic Publication: 2022 Sep 24.
Typ publikacji:
Journal Article
MeSH Terms:
Reactive Oxygen Species*
Risk Factors
Czasopismo naukowe
Tytuł:
Impact of calcium and reactive oxygen species on human sperm function: Role of NOX5.
Autorzy:
Keshtgar S; Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Ghani E; Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.; Department of Physiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
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Źródło:
Andrologia [Andrologia] 2022 Sep; Vol. 54 (8), pp. e14470. Date of Electronic Publication: 2022 Jun 09.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium*/metabolism
NADPH Oxidase 5*/genetics
NADPH Oxidase 5*/metabolism
Reactive Oxygen Species*/metabolism
Spermatozoa*/drug effects
Spermatozoa*/metabolism
Calcimycin/pharmacology ; Humans ; Male ; Semen/drug effects ; Semen/metabolism ; Sperm Motility/drug effects ; Sperm Motility/genetics ; Sperm Motility/physiology
Czasopismo naukowe
Tytuł:
Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release.
Autorzy:
Jaén RI; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.
Povo-Retana A; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.
Rosales-Mendoza C; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.
Capillas-Herrero P; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.
Sánchez-García S; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.
Martín-Sanz P; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Mojena M; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.
Prieto P; Departamento de Farmacología, Farmacognosia y Botánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Boscá L; Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 14; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 14.
Typ publikacji:
Journal Article
MeSH Terms:
Atherosclerosis*/metabolism
Macrophages*/metabolism
Proprotein Convertase 9*/genetics
Proprotein Convertase 9*/metabolism
Reactive Oxygen Species*/metabolism
Cholesterol, LDL/metabolism ; Humans ; Receptors, LDL/genetics ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł:
REDD1 interacts with AIF and regulates mitochondrial reactive oxygen species generation in the keratinocyte response to UVB.
Autorzy:
Feehan RP; Department of Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. Electronic address: .
Coleman CS; Department of Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. Electronic address: .
Ebanks S; Department of Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. Electronic address: .
Lang CH; Department of Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. Electronic address: .
Shantz LM; Department of Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Aug 06; Vol. 616, pp. 56-62. Date of Electronic Publication: 2022 May 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis Inducing Factor*/genetics
Apoptosis Inducing Factor*/metabolism
Keratinocytes*/metabolism
Keratinocytes*/radiation effects
Reactive Oxygen Species*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Electron Transport Complex I/genetics ; Electron Transport Complex I/metabolism ; Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
Czasopismo naukowe
Tytuł:
2-hydroxyethyl methacrylate-derived reactive oxygen species stimulate ATP release via TRPA1 in human dental pulp cells.
Autorzy:
Orimoto A; Division of Endodontics and Restorative Dentistry, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, 803-8580, Japan. .
Kitamura C; Division of Endodontics and Restorative Dentistry, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, 803-8580, Japan.
Ono K; Division of Physiology, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, 803-8580, Japan.
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 19; Vol. 12 (1), pp. 12343. Date of Electronic Publication: 2022 Jul 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine Triphosphate*/metabolism
Dental Pulp*/metabolism
Methacrylates*/metabolism
Osteogenesis*
Reactive Oxygen Species*/metabolism
TRPA1 Cation Channel*/metabolism
Cytoskeletal Proteins/metabolism ; Humans
Czasopismo naukowe
Tytuł:
Serum Derivatives of Reactive Oxygen Metabolites are Associated with Severity of Chronic Obstructive Pulmonary Disease and Affected by a p53 Gene Polymorphism.
Autorzy:
Yamamura K; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Nojiri M; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Nishiki K; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Kato R; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Shinomiya S; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Takahara Y; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Oikawa T; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Ishizaki T; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Toga H; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
Mizuno S; Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
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Źródło:
International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2022 Jul 13; Vol. 17, pp. 1589-1600. Date of Electronic Publication: 2022 Jul 13 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Emphysema*/complications
Pulmonary Disease, Chronic Obstructive*/complications
Pulmonary Disease, Chronic Obstructive*/diagnosis
Pulmonary Disease, Chronic Obstructive*/genetics
Pulmonary Emphysema*/blood
Pulmonary Emphysema*/diagnosis
Pulmonary Emphysema*/genetics
Reactive Oxygen Species*/blood
Humans ; Polymorphism, Genetic ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł:
Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I.
Autorzy:
Rodríguez-Nuevo A; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Torres-Sanchez A; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Duran JM; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
De Guirior C; Gynaecology Department, Institute Clinic of Gynaecology, Obstetrics and Neonatology, Hospital Clinic, Barcelona, Barcelona, Spain.; Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Martínez-Zamora MA; Gynaecology Department, Institute Clinic of Gynaecology, Obstetrics and Neonatology, Hospital Clinic, Barcelona, Barcelona, Spain.; Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Böke E; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. .; Universitat Pompeu Fabra (UPF), Barcelona, Spain. .
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Źródło:
Nature [Nature] 2022 Jul; Vol. 607 (7920), pp. 756-761. Date of Electronic Publication: 2022 Jul 20.
Typ publikacji:
Journal Article
MeSH Terms:
Electron Transport Complex I*/antagonists & inhibitors
Electron Transport Complex I*/metabolism
Mitochondria*/metabolism
Oocytes*/cytology
Oocytes*/enzymology
Oocytes*/metabolism
Reactive Oxygen Species*
Animals ; Electron Transport ; Female ; Humans ; Proteomics ; Unfolded Protein Response ; Xenopus laevis
Czasopismo naukowe
Tytuł:
Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport.
Autorzy:
Roca FJ; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Whitworth LJ; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
Murphy MP; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
Ramakrishnan L; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jun 24; Vol. 376 (6600), pp. eabh2841. Date of Electronic Publication: 2022 Jun 24.
Typ publikacji:
Journal Article
MeSH Terms:
Electron Transport Complex I*/antagonists & inhibitors
Electron Transport Complex I*/metabolism
Macrophages*/metabolism
Macrophages*/microbiology
Macrophages*/pathology
Metformin*/pharmacology
Mycobacterium tuberculosis*/metabolism
Reactive Oxygen Species*/metabolism
Tuberculosis*/metabolism
Tuberculosis*/microbiology
Tuberculosis*/pathology
Tumor Necrosis Factor-alpha*/metabolism
Animals ; Citric Acid Cycle/drug effects ; Electron Transport ; Humans ; Necrosis ; Succinic Acid/metabolism ; Zebrafish
Czasopismo naukowe
Tytuł:
Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence, and Inflammation via Toll-like Receptor 4, Reactive Oxygen Species, and p38 MAPK Signaling.
Autorzy:
Tong M; Yale School of Medicine, New Haven, Connecticut.
Kayani T; Yale School of Medicine, New Haven, Connecticut.
Jones DM; The University of Auckland, New Zealand.
Salmon JE; Weill Cornell Medicine, New York, New York.
Whirledge S; Yale School of Medicine, New Haven, Connecticut.
Chamley LW; The University of Auckland, New Zealand.
Abrahams VM; Yale School of Medicine, New Haven, Connecticut.
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Źródło:
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2022 Jun; Vol. 74 (6), pp. 1001-1012. Date of Electronic Publication: 2022 Apr 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Antiphospholipid*/metabolism
MAP Kinase Signaling System*
Reactive Oxygen Species*/metabolism
Stromal Cells*/metabolism
Toll-Like Receptor 4*/metabolism
p38 Mitogen-Activated Protein Kinases*/metabolism
Animals ; Endometrium/metabolism ; Female ; Heparin, Low-Molecular-Weight/pharmacology ; Immunoglobulin G/metabolism ; Inflammation/metabolism ; Mice ; Pregnancy
Czasopismo naukowe
Tytuł:
Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of Waltheria indica .
Autorzy:
Liu F; Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.; School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Mallick S; Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.
O'Donnell TJ; Department of Chemistry, 2545 McCarthy Mall, University of Hawai'i at Manoa, Honolulu, HI 96822, USA.
Rouzimaimaiti R; Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.
Luo Y; Department of Chemistry, 2545 McCarthy Mall, University of Hawai'i at Manoa, Honolulu, HI 96822, USA.
Sun R; Department of Chemistry, 2545 McCarthy Mall, University of Hawai'i at Manoa, Honolulu, HI 96822, USA.
Wall M; Daniel K. Inouye U.S. Pacific Basin Agricultural Research Center, USDA-ARS, Hilo, HI 96720, USA.
Wongwiwatthananukit S; Department of Pharmacy Practice, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.
Date A; Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.; Department of Pharmacology and Toxicology, R. K. Coit College of Pharmacy, University of Arizona, Tucson, AZ 85715, USA.
Silva DK; Hale Ola Pono, LLC, Keaau, HI 96749, USA.
Williams PG; Department of Chemistry, 2545 McCarthy Mall, University of Hawai'i at Manoa, Honolulu, HI 96822, USA.
Chang LC; Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 May 19; Vol. 27 (10). Date of Electronic Publication: 2022 May 19.
Typ publikacji:
Journal Article
MeSH Terms:
Coumarins*/chemistry
Coumarins*/pharmacology
Lignans*/chemistry
Lignans*/pharmacology
Malvaceae*/chemistry
NF-kappa B*/antagonists & inhibitors
Reactive Oxygen Species*/antagonists & inhibitors
HEK293 Cells ; HeLa Cells ; Humans ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł:
An Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils.
Autorzy:
Ellson CD; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Riça IG; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Kim JS; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Huang YM; Department of Chemistry, University of California, Riverside CA92521, USA.
Lim D; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Mitra T; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Hsu A; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Wei EX; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215 USA.
Barrett CD; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA. Electronic address: https://twitter.com/ChrisBarrettMD.
Otterbein LE; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA.
Hauser CJ; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA.
Wahl M; Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Delbrück H; Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Heinemann U; Chemistry and Biochemistry Institute, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA.
Oschkinat H; Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany; Chemistry and Biochemistry Institute, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
Chang CA; Department of Chemistry, University of California, Riverside CA92521, USA. Electronic address: https://twitter.com/ChiaenChang1.
Yaffe MB; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 May 15; Vol. 434 (9), pp. 167533. Date of Electronic Publication: 2022 Mar 18.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Class I Phosphatidylinositol 3-Kinases*/metabolism
NADPH Oxidases*/genetics
NADPH Oxidases*/metabolism
Neutrophils*/enzymology
Reactive Oxygen Species*/metabolism
Animals ; Enzyme Activation ; Inflammation ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł:
Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.
Autorzy:
Kim D; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155, Gaetbeol-ro, Yeonsu-gu, Incheon, 21999, Republic of Korea.
Nam GY; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191, Hambangmoe-ro, Yeonsu-gu, Incheon, 21936, Republic of Korea.
Seo E; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155, Gaetbeol-ro, Yeonsu-gu, Incheon, 21999, Republic of Korea.; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191, Hambangmoe-ro, Yeonsu-gu, Incheon, 21936, Republic of Korea.
Jun HS; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155, Gaetbeol-ro, Yeonsu-gu, Incheon, 21999, Republic of Korea. .; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191, Hambangmoe-ro, Yeonsu-gu, Incheon, 21936, Republic of Korea. .; Gachon Medical Research Institute, Gil Hospital, 21, Namdong-daero 774beon-gil, Namdong-gu, Incheon, 21565, Republic of Korea. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2022 May 10; Vol. 29 (1), pp. 31. Date of Electronic Publication: 2022 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/metabolism
Diabetic Nephropathies*/metabolism
Diabetic Nephropathies*/pathology
Lysophospholipids*
Mesangial Cells*/drug effects
Mesangial Cells*/metabolism
Mesangial Cells*/pathology
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Reactive Oxygen Species*/metabolism
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Animals ; Down-Regulation ; Female ; Fibronectins/metabolism ; Fibrosis ; Male ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; TNF Receptor-Associated Factor 4/metabolism ; Transforming Growth Factor beta/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł:
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
Autorzy:
Feng S; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
Wan S; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
Liu S; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
Wang W; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
Tang M; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
Bai L; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education) and Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
Zhu Y; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education) and Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
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Źródło:
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 May 09; Vol. 2022, pp. 5501346. Date of Electronic Publication: 2022 May 09 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Amino Acyl-tRNA Synthetases*/metabolism
Endoplasmic Reticulum Stress*
Mitochondria*/enzymology
Primary Ovarian Insufficiency*/metabolism
Primary Ovarian Insufficiency*/pathology
Reactive Oxygen Species*/metabolism
Apoptosis ; Female ; Granulosa Cells/metabolism ; Humans
Czasopismo naukowe

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