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Wyszukujesz frazę ""Receptor, Angiotensin, Type 1"" wg kryterium: Temat


Tytuł :
Angiotensin II type 1 receptor variants alter endosomal receptor-β-arrestin complex stability and MAPK activation.
Autorzy :
Cao Y; Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada.
Kumar S; Department of Medicine, McGill University Health Center, McGill University, Montréal, Québec, Canada.
Namkung Y; Department of Medicine, McGill University Health Center, McGill University, Montréal, Québec, Canada.
Gagnon L; Department of Medicine, McGill University Health Center, McGill University, Montréal, Québec, Canada.
Cho A; Department of Medicine, McGill University Health Center, McGill University, Montréal, Québec, Canada.
Laporte SA; Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada .; Department of Medicine, McGill University Health Center, McGill University, Montréal, Québec, Canada.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Sep 18; Vol. 295 (38), pp. 13169-13180. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Endosomes/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Receptor, Angiotensin, Type 1/*metabolism
beta-Arrestins/*metabolism
Amino Acid Substitution ; Angiotensin II/pharmacology ; Endosomes/genetics ; Enzyme Activation ; HEK293 Cells ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Mutation, Missense ; Receptor, Angiotensin, Type 1/genetics ; beta-Arrestins/genetics
Czasopismo naukowe
Tytuł :
Unraveling the Prevalence of Angiotensin II Type 1 Receptor Antibodies in Hypertension.
Autorzy :
Philippe A; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Medical Intensive Care, CVK, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Cardiovascular Research, AG Dragun, Berlin, Germany.
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Źródło :
American journal of hypertension [Am J Hypertens] 2020 Aug 04; Vol. 33 (8), pp. 711-712.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Hypertension*
Receptor, Angiotensin, Type 1*
Antibodies ; Blood Pressure ; Humans ; Prevalence
Czasopismo naukowe
Tytuł :
RhoA/ROCK Pathway Activation is Regulated by AT1 Receptor and Participates in Smooth Muscle Migration and Dedifferentiation via Promoting Actin Cytoskeleton Polymerization.
Autorzy :
Qi Y; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Liang X; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Dai F; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Guan H; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Sun J; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Yao W; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 29; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Actin Cytoskeleton/*drug effects
Angiotensin II/*pharmacology
Cell Dedifferentiation/*drug effects
Myocytes, Smooth Muscle/*drug effects
Receptor, Angiotensin, Type 1/*genetics
rho-Associated Kinases/*genetics
rhoA GTP-Binding Protein/*genetics
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Actin Cytoskeleton/genetics ; Actin Cytoskeleton/metabolism ; Actins/genetics ; Actins/metabolism ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Cell Line ; Cell Movement/drug effects ; Gene Expression Regulation ; Humans ; Irbesartan/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; Polymerization/drug effects ; Protein Kinase Inhibitors/pharmacology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction ; Vasodilator Agents/pharmacology ; rho-Associated Kinases/metabolism ; rhoA GTP-Binding Protein/antagonists & inhibitors ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Training-Induced Deactivation of the AT 1 Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats.
Autorzy :
da Costa TSR; Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo.
Masson GS; Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo.
Eichler RADS; Department of Pharmacology, Biomedical Sciences Institute, University of Sao Paulo.
Silva JCS; Department of Anatomy, Biomedical Sciences Institute, University of Sao Paulo.
Lacchini S; Department of Anatomy, Biomedical Sciences Institute, University of Sao Paulo.
Michelini LC; Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo.
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Źródło :
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2020 Jul 22; Vol. 84 (8), pp. 1294-1303. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Exercise Therapy*
Ventricular Function, Left*
Ventricular Remodeling*
Heart/*innervation
Hypertension/*prevention & control
Prehypertension/*therapy
Receptor, Angiotensin, Type 1/*metabolism
Sympathetic Nervous System/*physiopathology
Animals ; Blood Pressure ; Disease Models, Animal ; Down-Regulation ; Hypertension/genetics ; Hypertension/metabolism ; Hypertension/physiopathology ; Prehypertension/genetics ; Prehypertension/metabolism ; Prehypertension/physiopathology ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptor, Angiotensin, Type 1/genetics ; Signal Transduction ; Time Factors
Czasopismo naukowe
Tytuł :
Withaferin A: a potential therapeutic agent against COVID-19 infection.
Autorzy :
Straughn AR; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA.
Kakar SS; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA. .; Department of Physiology, University of Louisville School of Medicine, 500 South Floyd Street, Louisville, KY, 40202, USA. .
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Źródło :
Journal of ovarian research [J Ovarian Res] 2020 Jul 19; Vol. 13 (1), pp. 79. Date of Electronic Publication: 2020 Jul 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Angiotensin II/*drug effects
Coronavirus Infections/*drug therapy
Peptidyl-Dipeptidase A/*drug effects
Pneumonia, Viral/*drug therapy
Receptor, Angiotensin, Type 1/*drug effects
Withanolides/*pharmacology
Angiotensin II/metabolism ; Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/metabolism ; COVID-19 ; Cachexia/metabolism ; Female ; Humans ; Mice ; Ovarian Neoplasms/drug therapy ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Receptor, Angiotensin, Type 1/genetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism ; Xenograft Model Antitumor Assays
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Immobilized angiotensin II type I receptor: A powerful method of high throughput screening for antihypertensive compound identification through binding interaction analysis.
Autorzy :
Liang Q; College of Life Sciences, Northwest University, Xi'an 710069, China; College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.
Fu X; College of Life Sciences, Northwest University, Xi'an 710069, China.
Zhang J; Department of Pharmacy, Eighth Hospital of Xi'an City, Xi'an 710061, China.
Hao J; College of Life Sciences, Northwest University, Xi'an 710069, China.
Feng G; College of Life Sciences, Northwest University, Xi'an 710069, China.
Wang J; College of Life Sciences, Northwest University, Xi'an 710069, China.
Li Q; College of Life Sciences, Northwest University, Xi'an 710069, China.
Ahmad F; College of Life Sciences, Northwest University, Xi'an 710069, China.
Zhao X; College of Life Sciences, Northwest University, Xi'an 710069, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2020 Jun 07; Vol. 1620, pp. 461003. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antihypertensive Agents/*metabolism
High-Throughput Screening Assays/*methods
Receptor, Angiotensin, Type 1/*metabolism
Antihypertensive Agents/chemistry ; Benzimidazoles/chemistry ; Benzimidazoles/metabolism ; Binding Sites ; Chromatography, Affinity ; Cinnamates/metabolism ; Depsides/metabolism ; Imidazoles/chemistry ; Imidazoles/metabolism ; Immobilized Proteins/chemistry ; Immobilized Proteins/metabolism ; Isoflavones/metabolism ; Kinetics ; Ligands ; Molecular Docking Simulation ; Oxadiazoles/chemistry ; Oxadiazoles/metabolism ; Receptor, Angiotensin, Type 1/chemistry ; Receptor, Angiotensin, Type 1/genetics ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Tetrazoles/chemistry ; Tetrazoles/metabolism ; Thermodynamics ; Valsartan/chemistry ; Valsartan/metabolism
Czasopismo naukowe
Tytuł :
Purinergic P2X 1 receptor, purinergic P2X 7 receptor, and angiotensin II type 1 receptor interactions in the regulation of renal afferent arterioles in angiotensin II-dependent hypertension.
Autorzy :
Kulthinee S; Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Science Center, New Orleans, Louisiana.; Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Shao W; Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Science Center, New Orleans, Louisiana.
Franco M; Department of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología 'Ignacio Chávez,' México City, México.
Navar LG; Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Science Center, New Orleans, Louisiana.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Jun 01; Vol. 318 (6), pp. F1400-F1408. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Pressure*/drug effects
Arterioles/*metabolism
Hypertension/*metabolism
Kidney/*blood supply
Receptor, Angiotensin, Type 1/*metabolism
Receptors, Purinergic P2X1/*metabolism
Receptors, Purinergic P2X7/*metabolism
Angiotensin II ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Antihypertensive Agents/pharmacology ; Arterioles/drug effects ; Arterioles/physiopathology ; Disease Models, Animal ; Hypertension/chemically induced ; Hypertension/drug therapy ; Hypertension/physiopathology ; Male ; Purinergic P2X Receptor Antagonists/pharmacology ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/drug effects ; Receptors, Purinergic P2X1/drug effects ; Receptors, Purinergic P2X7/drug effects ; Signal Transduction
Czasopismo naukowe
Tytuł :
Anomalous AMPK-regulated angiotensin AT 1 R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Autorzy :
Chao YM; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.
Wu KLH; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.
Tsai PC; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.
Tain YL; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung Univeristy College of Medicine, Kaohsiung, 83301, Taiwan.
Leu S; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.
Lee WC; Division of Urology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.
Chan JYH; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan. .
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Źródło :
Journal of biomedical science [J Biomed Sci] 2020 May 23; Vol. 27 (1), pp. 68. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
AMP-Activated Protein Kinases/*genetics
Fructose/*administration & dosage
Mitochondria/*physiology
Receptor, Angiotensin, Type 1/*genetics
Sirtuin 1/*genetics
AMP-Activated Protein Kinases/metabolism ; Animals ; Female ; Hypertension/genetics ; Maternal Exposure ; Organelle Biogenesis ; Rats ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/metabolism ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
Exploring the role of the membrane bilayer in the recognition of candesartan by its GPCR AT1 receptor.
Autorzy :
Kiriakidi S; National and Kapodistrian University of Athens, Department of Chemistry, Athens, Greece.
Chatzigiannis C; University of Ioannina, Department of Chemistry, Section of Organic Chemistry and Biochemistry, Ioannina, Greece.
Papaemmanouil C; University of Ioannina, Department of Chemistry, Section of Organic Chemistry and Biochemistry, Ioannina, Greece.
Tzakos AG; University of Ioannina, Department of Chemistry, Section of Organic Chemistry and Biochemistry, Ioannina, Greece.
Mavromoustakos T; National and Kapodistrian University of Athens, Department of Chemistry, Athens, Greece. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Mar 01; Vol. 1862 (3), pp. 183142. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzimidazoles/*chemistry
Benzimidazoles/*pharmacology
Receptor, Angiotensin, Type 1/*drug effects
Tetrazoles/*chemistry
Tetrazoles/*pharmacology
Angiotensin II Type 1 Receptor Blockers/chemistry ; Angiotensin II Type 1 Receptor Blockers/metabolism ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Humans ; Hypertension/drug therapy ; Lipid Bilayers/metabolism ; Magnetic Resonance Spectroscopy ; Membranes/metabolism ; Molecular Conformation ; Molecular Dynamics Simulation ; Receptor, Angiotensin, Type 1/metabolism ; Receptor, Angiotensin, Type 1/ultrastructure ; Receptors, G-Protein-Coupled/drug effects ; Receptors, G-Protein-Coupled/metabolism ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology
Czasopismo naukowe
Tytuł :
Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors.
Autorzy :
Azushima K; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Morisawa N; Department of Pharmacology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa, Japan.
Tamura K; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Nishiyama A; Department of Pharmacology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa, Japan. .
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Źródło :
Current hypertension reports [Curr Hypertens Rep] 2020 Feb 29; Vol. 22 (3), pp. 22. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hypertension*
Receptor, Angiotensin, Type 1*/drug effects
Receptor, Angiotensin, Type 1*/physiology
Receptor, Angiotensin, Type 2*/drug effects
Receptor, Angiotensin, Type 2*/physiology
Renin-Angiotensin System*/drug effects
Angiotensin II ; Angiotensin II Type 1 Receptor Blockers ; Angiotensin II Type 2 Receptor Blockers ; Humans
Czasopismo naukowe
Tytuł :
Lipoxin A 4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1.
Autorzy :
Liu H; Department of Rheumatology and Immunology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430033, PR China.
Cheng F; Department of Clinical Laboratory, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430033, PR China.
Xu Q; Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China.
Huang W; Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China.
Wang S; Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China.
Sun R; Department of Oncology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430033, PR China.
Ye D; Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China. .
Zhang D; Department of Clinical Laboratory, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430033, PR China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2020 Jan 30; Vol. 11 (1), pp. 78. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoantibodies/*metabolism
Caspase 1/*metabolism
Lipoxins/*pharmacology
Pre-Eclampsia/*immunology
Pyroptosis/*drug effects
Receptor, Angiotensin, Type 1/*immunology
Trophoblasts/*drug effects
Angiotensin Receptor Antagonists ; Animals ; Autoantibodies/genetics ; Autoantibodies/immunology ; Caspase 1/blood ; Caspase 1/deficiency ; Caspase 1/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Cells, Cultured ; Cytokines/metabolism ; Female ; Humans ; Lipopolysaccharides/pharmacology ; Lipoxins/blood ; Lipoxins/deficiency ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Pre-Eclampsia/blood ; Pre-Eclampsia/metabolism ; Pregnancy ; Pyroptosis/genetics ; Pyroptosis/immunology ; RNA, Small Interfering ; Receptor, Angiotensin, Type 1/blood ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 1/metabolism ; Spleen/growth & development ; Spleen/immunology ; Spleen/pathology ; Trophoblasts/metabolism
Czasopismo naukowe
Tytuł :
Relationship between A1166C polymorphism of angiotensin II type 1 receptor gene and arteriosclerosis: A protocol for systematic review and meta-analysis.
Autorzy :
Shi Z; Wenzhou Central Hospital, Wenzhou, Zhejiang Province, China.
Wang J
Chen S
Dai H
Huang Y
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 29; Vol. 100 (4), pp. e24407.
Typ publikacji :
Journal Article
MeSH Terms :
Arteriosclerosis/*genetics
Genetic Predisposition to Disease/*genetics
Polymorphism, Genetic/*genetics
Receptor, Angiotensin, Type 1/*genetics
Humans ; Meta-Analysis as Topic ; Observational Studies as Topic ; Research Design ; Systematic Reviews as Topic
Czasopismo naukowe
Tytuł :
Cutaneous inflammation differentially regulates the expression and function of Angiotensin-II types 1 and 2 receptors in rat primary sensory neurons.
Autorzy :
Benitez SG; Laboratorio de Neurobiología del Dolor, Instituto de Histología y Embriología de Mendoza (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Seltzer AM; Laboratorio de Neurobiología, Instituto de Embriología e Histología (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Messina DN; Laboratorio de Neurobiología del Dolor, Instituto de Histología y Embriología de Mendoza (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Foscolo MR; Laboratorio de Neurobiología del Dolor, Instituto de Histología y Embriología de Mendoza (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Patterson SI; Departamento de Morfofisiología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.; Instituto de Histología y Embriología - CONICET, Universidad Nacional de Cuyo, Mendoza, Argentina.
Acosta CG; Laboratorio de Neurobiología del Dolor, Instituto de Histología y Embriología de Mendoza (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Mar; Vol. 152 (6), pp. 675-696. Date of Electronic Publication: 2019 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dermatitis/*physiopathology
Receptor, Angiotensin, Type 1/*physiology
Receptor, Angiotensin, Type 2/*physiology
Sensory Receptor Cells/*physiology
Animals ; Cells, Cultured ; Dermatitis/etiology ; Female ; Freund's Adjuvant/administration & dosage ; Ganglia, Spinal/cytology ; Neurites/physiology ; Pain/physiopathology ; Rats ; Rats, Wistar ; Receptor, Angiotensin, Type 1/analysis ; Receptor, Angiotensin, Type 2/analysis ; Sensory Receptor Cells/chemistry ; Skin/innervation
Czasopismo naukowe
Tytuł :
Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays.
Autorzy :
Qu L; Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang J; Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; DICP-CMC Innovation Institute of Medicine, Taizhou 225300, China.
Hou T; Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Zhou H; Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Wang Z; DICP-CMC Innovation Institute of Medicine, Taizhou 225300, China.
Zhang X; College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, China; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China. Electronic address: .
Liang X; Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; DICP-CMC Innovation Institute of Medicine, Taizhou 225300, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China. Electronic address: .
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Źródło :
Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2020 Mar - Apr; Vol. 102, pp. 106682. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II/*metabolism
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Antihypertensive Agents/*pharmacology
Receptor, Angiotensin, Type 1/*drug effects
Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Antihypertensive Agents/administration & dosage ; Binding, Competitive ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; Protein Binding ; Receptor, Angiotensin, Type 1/metabolism
Czasopismo naukowe
Tytuł :
Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling.
Autorzy :
Binz-Lotter J; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; and.
Jüngst C; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Rinschen MM; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; and.
Koehler S; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; and.
Zentis P; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Schauss A; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Schermer B; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; and.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Benzing T; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; and.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Hackl MJ; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; and .
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Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2020 Mar; Vol. 31 (3), pp. 532-542. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Calcium Signaling/*drug effects
Intracellular Signaling Peptides and Proteins/*metabolism
Losartan/*pharmacology
Membrane Proteins/*metabolism
Receptor, Angiotensin, Type 1/*metabolism
Animals ; Cells, Cultured ; Disease Models, Animal ; Glomerulonephritis/metabolism ; Glomerulonephritis/physiopathology ; Humans ; Kidney Glomerulus/drug effects ; Kidney Glomerulus/metabolism ; Male ; Mice ; Podocytes/drug effects ; Podocytes/metabolism ; Proteinuria/metabolism ; Proteinuria/physiopathology ; Random Allocation ; Receptor, Angiotensin, Type 1/drug effects ; Reference Values
Czasopismo naukowe
Tytuł :
A male-specific association between AGTR1 hypermethylation and coronary heart disease.
Autorzy :
Li X; Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University, Ningbo, China.
Wu N; Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University, Ningbo, China.
Ji H; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.
Huang Y; Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University, Ningbo, China.
Hu H; Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University, Ningbo, China.
Li J; Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University, Ningbo, China.
Mi S; Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University, Ningbo, China.
Duan S; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China. .
Chen X; Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University, Ningbo, China. .
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Źródło :
Bosnian journal of basic medical sciences [Bosn J Basic Med Sci] 2020 Feb 05; Vol. 20 (1), pp. 31-36. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Asian Continental Ancestry Group/*genetics
Coronary Disease/*genetics
DNA Methylation/*genetics
Receptor, Angiotensin, Type 1/*genetics
Aged ; Case-Control Studies ; China ; Coronary Disease/diagnosis ; Coronary Disease/metabolism ; Female ; Humans ; Male ; Middle Aged ; Receptor, Angiotensin, Type 1/metabolism ; Sex Factors
Czasopismo naukowe
Tytuł :
Hyperacute graft dysfunction in an orthotopic heart transplant in the presence of non-HLA antibodies.
Autorzy :
Villa C; HLA Lab, Vitalant, Spokane, Washington.
Mesa K; Mechanical Heart Program, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, Washington.
Cristy Smith M; Center for Advanced Heart Disease and Transplantation, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, Washington.
Mooney DM; Center for Advanced Heart Disease and Transplantation, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, Washington.
Coletti A; Center for Advanced Heart Disease and Transplantation, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, Washington.
Klohe E; HLA Lab, Vitalant, Spokane, Washington.
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Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2020 Feb; Vol. 20 (2), pp. 593-599. Date of Electronic Publication: 2019 Sep 09.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heart Transplantation*
Graft Rejection/*etiology
Receptor, Angiotensin, Type 1/*agonists
Adult ; Aged ; Blood Grouping and Crossmatching ; Extracorporeal Membrane Oxygenation ; Graft Rejection/immunology ; HLA Antigens/immunology ; Histocompatibility Testing ; Humans ; Male ; Primary Graft Dysfunction/etiology ; Receptor, Angiotensin, Type 1/immunology
Czasopismo naukowe
Tytuł :
Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia.
Autorzy :
Vaka VR; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Cunningham MW; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Deer E; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Franks M; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Ibrahim T; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Amaral LM; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Usry N; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Cornelius DC; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Dechend R; Experimental and Clinical Research Center, HELIOS Clinic, Berlin, Germany.
Wallukat G; Experimental and Clinical Research Center, Charité Campus Buch, Max-Delbrück Center for Molecular Medicine, Berlin, Germany.
LaMarca BD; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.; Department of Obstetrics & Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2020 Feb 01; Vol. 318 (2), pp. R256-R262. Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antihypertensive Agents/*pharmacology
Autoantibodies/*metabolism
Blood Pressure/*drug effects
Kidney/*drug effects
Mitochondria/*drug effects
Peptides/*pharmacology
Pre-Eclampsia/*drug therapy
Reactive Oxygen Species/*metabolism
Receptor, Angiotensin, Type 1/*immunology
Animals ; Cells, Cultured ; Disease Models, Animal ; Female ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Kidney/immunology ; Kidney/metabolism ; Kidney/physiopathology ; Mitochondria/immunology ; Mitochondria/metabolism ; Oxidative Stress/drug effects ; Pre-Eclampsia/immunology ; Pre-Eclampsia/metabolism ; Pre-Eclampsia/physiopathology ; Pregnancy ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo.
Autorzy :
Pollard CM; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Ghandour J; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Cora N; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Perez A; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Parker BM; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Desimine VL; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Wertz SL; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Pereyra JM; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Ferraino KE; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Patel JJ; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Lymperopoulos A; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 16; Vol. 21 (2). Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Aldosterone/*metabolism
G-Protein-Coupled Receptor Kinase 2/*metabolism
Receptor, Angiotensin, Type 1/*metabolism
Receptors, Adrenergic, beta/*metabolism
Zona Glomerulosa/*cytology
Zona Glomerulosa/*metabolism
Angiotensin II/genetics ; Angiotensin II/metabolism ; Blotting, Western ; Cell Line ; G-Protein-Coupled Receptor Kinase 2/genetics ; Humans ; Real-Time Polymerase Chain Reaction ; Receptor, Angiotensin, Type 1/genetics ; Receptors, Adrenergic, beta/genetics
Czasopismo naukowe
Tytuł :
Angiotensin II type I receptor agonistic autoantibodies are associated with poor allograft survival in liver retransplantation.
Autorzy :
Xu Q; Department of Pathology and Lab Medicine, London Health Sciences Centre, London, ON, Canada.; Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada.
McAlister VC; Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada.
Leckie S; Department of Pathology and Lab Medicine, London Health Sciences Centre, London, ON, Canada.
House AA; Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada.
Skaro A; Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada.
Marotta P; Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada.
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Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2020 Jan; Vol. 20 (1), pp. 282-288. Date of Electronic Publication: 2019 Sep 06.
Typ publikacji :
Journal Article
MeSH Terms :
Graft Survival*
Autoantibodies/*adverse effects
Graft Rejection/*mortality
Liver Diseases/*mortality
Liver Transplantation/*mortality
Receptor, Angiotensin, Type 1/*immunology
Adult ; Female ; Follow-Up Studies ; Graft Rejection/etiology ; Graft Rejection/pathology ; Humans ; Liver Diseases/surgery ; Liver Transplantation/adverse effects ; Male ; Prognosis ; Receptor, Angiotensin, Type 1/agonists ; Reoperation ; Retrospective Studies ; Risk Factors ; Survival Rate ; Transplantation, Homologous
Czasopismo naukowe

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