Temat: "Receptor, Angiotensin, Type 1" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Role of pregnancy on insulin-induced vasorelaxation: the influence of angiotensin II receptors.
Autorzy:: Rodríguez-Reyes B; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.
Tufiño C; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.
López Mayorga RM; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.
Mera Jiménez E; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.
Bobadilla Lugo RA; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, México.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2021 Oct; Vol. 99 (10), pp. 1026-1035. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Aorta, Thoracic/*drug effects
Insulin/*pharmacology
Muscle, Smooth, Vascular/*drug effects
Pregnancy, Animal/*physiology
Receptor, Angiotensin, Type 1/*metabolism
Receptor, Angiotensin, Type 2/*metabolism
Vasodilation/*drug effects
Angiotensin II/metabolism ; Animals ; Aorta, Thoracic/metabolism ; Aorta, Thoracic/physiology ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Female ; Hypoglycemic Agents/pharmacology ; Muscle, Smooth, Vascular/metabolism ; Pregnancy ; Rats ; Rats, Wistar ; Receptor, Angiotensin, Type 1/chemistry ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 2/chemistry ; Receptor, Angiotensin, Type 2/genetics ; Vasodilation/physiology

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Skocz do pozycji: 2.

Tytuł:: Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects.
Autorzy:: Tehrani AY; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada.
White Z; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada.
Tung LW; School of Biomedical Engineering and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Zhao RRY; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada.
Milad N; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada.
Seidman MA; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.
Sauge E; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada.
Theret M; School of Biomedical Engineering and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Rossi FMV; School of Biomedical Engineering and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Esfandiarei M; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada.; Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.
van Breemen C; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada.
Bernatchez P; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada. .; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Room 217, Vancouver, BC, V6T 1Z3, Canada. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jun 13; Vol. 12 (1), pp. 9771. Date of Electronic Publication: 2022 Jun 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers*/pharmacology
Angiotensin Receptor Antagonists*
Angiotensin II/metabolism ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Mice ; Nitric Oxide/metabolism ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 1/metabolism ; Telmisartan/pharmacology ; Vascular Remodeling

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Skocz do pozycji: 3.

Tytuł:: Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia.
Autorzy:: Booz GW; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Kennedy D; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Bowling M; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Robinson T; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Azubuike D; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Fisher B; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Brooks K; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Chinthakuntla P; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Hoang NH; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA.
Hosler JP; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA.
Cunningham MW Jr; Department of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA. .; Pokaż więcej
Źródło:: Biology of sex differences [Biol Sex Differ] 2021 Nov 02; Vol. 12 (1), pp. 58. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hypertension*/drug therapy
Pre-Eclampsia*/drug therapy
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Autoantibodies/*pharmacology
Mitochondria, Heart/*physiology
Animals ; Female ; Placenta ; Postpartum Period ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1

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Skocz do pozycji: 4.

Tytuł:: Discovery of Novel Multi-target Inhibitor of angiotensin type 1 receptor and neprilysin inhibitors from Traditional Chinese Medicine.
Autorzy:: Huo X; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
Qiao L; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
Chen Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
Chen X; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
He Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
Zhang Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Nov 07; Vol. 9 (1), pp. 16205. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Discovery*
Medicine, Chinese Traditional*
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Neprilysin/*antagonists & inhibitors
Receptor, Angiotensin, Type 1/*metabolism
Angiotensin II Type 1 Receptor Blockers/metabolism ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Chronic Disease ; Drug Evaluation, Preclinical ; Heart Failure/drug therapy ; Hypertension/drug therapy ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Targeted Therapy ; Neprilysin/chemistry ; Neprilysin/metabolism ; Protein Conformation ; Receptor, Angiotensin, Type 1/chemistry

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Skocz do pozycji: 5.

Tytuł:: Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes.
Autorzy:: Delaitre C; CITHEFOR, Université de Lorraine, F-54000 Nancy, France.; Biotechnologie et Signalisation Cellulaire, UMR7242 CNRS/Université de Strasbourg, 300 Boulevard Sébastien Brant, CS 10413, CEDEX, 67412 Illkirch-Graffenstaden, France.
Boisbrun M; CNRS, L2CM, Université de Lorraine, F-54000 Nancy, France.
Lecat S; Biotechnologie et Signalisation Cellulaire, UMR7242 CNRS/Université de Strasbourg, 300 Boulevard Sébastien Brant, CS 10413, CEDEX, 67412 Illkirch-Graffenstaden, France.
Dupuis F; CITHEFOR, Université de Lorraine, F-54000 Nancy, France.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 23; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 23.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Cardiovascular Diseases/*drug therapy
Receptor, Angiotensin, Type 1/*chemistry
Receptor, Angiotensin, Type 1/*metabolism
Animals ; Brain Injuries, Traumatic/metabolism ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Humans ; Intracranial Aneurysm/metabolism ; Molecular Targeted Therapy/methods ; Signal Transduction/drug effects ; Stroke/metabolism ; beta-Arrestins/agonists ; beta-Arrestins/metabolism

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Skocz do pozycji: 6.

Tytuł:: Rational Design and Synthesis of AT1R Antagonists.
Autorzy:: Georgiou N; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Gkalpinos VK; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
Katsakos SD; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
Vassiliou S; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Tzakos AG; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.; University Research Center of Ioannina (URCI), Institute of Materials Science and Computing, 45110 Ioannina, Greece.
Mavromoustakos T; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 May 14; Vol. 26 (10). Date of Electronic Publication: 2021 May 14.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Design*
Angiotensin II Type 1 Receptor Blockers/*chemical synthesis
Receptor, Angiotensin, Type 1/*metabolism
Angiotensin II Type 1 Receptor Blockers/chemistry ; Animals ; Humans ; Prodrugs/chemical synthesis ; Prodrugs/chemistry

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Skocz do pozycji: 7.

Tytuł:: AT 1 receptor blocker, but not an ACE inhibitor, prevents kidneys from hypoperfusion during congestive heart failure in normotensive and hypertensive rats.
Autorzy:: Kratky V; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 1958/9 Videnska, 14000, Prague 4, Czech Republic. .; Department of Pathophysiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. .; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. .
Vanourkova Z; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 1958/9 Videnska, 14000, Prague 4, Czech Republic.
Sykora M; Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Bacova BS; Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Hruskova Z; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Kikerlova S; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 1958/9 Videnska, 14000, Prague 4, Czech Republic.
Huskova Z; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 1958/9 Videnska, 14000, Prague 4, Czech Republic.
Kopkan L; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 1958/9 Videnska, 14000, Prague 4, Czech Republic.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Feb 19; Vol. 11 (1), pp. 4271. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Heart Failure/*complications
Renal Insufficiency/*etiology
Renal Insufficiency/*prevention & control
Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Biomarkers ; Blood Pressure ; Disease Models, Animal ; Disease Susceptibility ; Heart Failure/etiology ; Hemodynamics/drug effects ; Hypertension/complications ; Rats ; Receptor, Angiotensin, Type 1/metabolism ; Renal Circulation/drug effects ; Renal Insufficiency/metabolism

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Skocz do pozycji: 8.

Tytuł:: In silico prediction of ARB resistance: A first step in creating personalized ARB therapy.
Autorzy:: Anderson SD; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Tabassum A; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Yeon JK; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Sharma G; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Santos P; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Soong TH; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Thu YW; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Nies I; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Kurita T; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Chandler A; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Alsamarah A; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Kanassatega RS; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Luo YL; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Botello-Smith WM; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.
Andresen BT; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2020 Nov 25; Vol. 16 (11), pp. e1007719. Date of Electronic Publication: 2020 Nov 25 (Print Publication: 2020).
Typ publikacji:: Journal Article
MeSH Terms:: Precision Medicine*
Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Imidazoles/*therapeutic use
Tetrazoles/*therapeutic use
Angiotensin II Type 1 Receptor Blockers/chemistry ; Humans ; Imidazoles/chemistry ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Polymorphism, Single Nucleotide ; Receptor, Angiotensin, Type 1/genetics ; Reproducibility of Results ; Tetrazoles/chemistry

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Skocz do pozycji: 9.

Tytuł:: Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning.
Autorzy:: Hara S; Department of Forensic Medicine, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan. .
Kobayashi M; Department of Legal Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-cho, Kahoku-gun, Ishikawa, 920-0293, Japan.
Kuriiwa F; Department of Forensic Medicine, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan.
Mizukami H; Department of Legal Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-cho, Kahoku-gun, Ishikawa, 920-0293, Japan.
Mukai T; Department of Legal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki City, Kanagawa, 216-8511, Japan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Feb 13; Vol. 10 (1), pp. 2602. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Angiotensin II Type 2 Receptor Blockers/*therapeutic use
Carbon Monoxide Poisoning/*drug therapy
Corpus Striatum/*drug effects
Hydroxyl Radical/*antagonists & inhibitors
Renin-Angiotensin System/*drug effects
Animals ; Carbon Monoxide Poisoning/metabolism ; Corpus Striatum/metabolism ; Hydroxyl Radical/metabolism ; Male ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/metabolism ; Receptor, Angiotensin, Type 2/metabolism

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Skocz do pozycji: 10.

Tytuł:: Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats.
Autorzy:: Luo J; Department of Cardiology, First Affiliated Hospital, Zhong-Shan University, Guangzhou, China.; Department of Geriatrics, Huizhou Municipal Central Hospital, Guangdong, China.
Chen X; Department of Cardiology, First Affiliated Hospital, Zhong-Shan University, Guangzhou, China.
Luo C; Department of Cardiology, First Affiliated Hospital, Zhong-Shan University, Guangzhou, China.
Lu G; Department of Cardiology, First Affiliated Hospital, Zhong-Shan University, Guangzhou, China.
Peng L; Department of Cardiology, First Affiliated Hospital, Zhong-Shan University, Guangzhou, China.
Gao X; Department of Cardiology, First Affiliated Hospital, Zhong-Shan University, Guangzhou, China.
Zuo Z; Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, USA.; Pokaż więcej
Źródło:: Cardiovascular therapeutics [Cardiovasc Ther] 2017 Apr; Vol. 35 (2).
Typ publikacji:: Comparative Study; Journal Article
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Diuretics/*pharmacology
Heart Failure/*drug therapy
Heart Ventricles/*drug effects
Hydrochlorothiazide/*pharmacology
Receptor, Angiotensin, Type 1/*drug effects
Ventricular Function, Left/*drug effects
Ventricular Remodeling/*drug effects
Aldosterone/blood ; Angiotensin II/blood ; Animals ; Animals, Newborn ; Cells, Cultured ; Disease Models, Animal ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis ; Furosemide/pharmacology ; Heart Failure/metabolism ; Heart Failure/pathology ; Heart Failure/physiopathology ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Male ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/metabolism ; Recovery of Function ; Signal Transduction/drug effects ; Smad2 Protein/metabolism ; Stroke Volume/drug effects ; Transforming Growth Factor beta1/metabolism ; Valsartan/pharmacology

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Skocz do pozycji: 11.

Tytuł:: Single-molecule force spectroscopy study of interactions between angiotensin II type 1 receptor and different biased ligands in living cells.
Autorzy:: Li W; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, 2 North First Street, Zhongguancun, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Xu J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, 2 North First Street, Zhongguancun, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Kou X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, 2 North First Street, Zhongguancun, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhao R; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, 2 North First Street, Zhongguancun, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhou W; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, 2 North First Street, Zhongguancun, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Fang X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, 2 North First Street, Zhongguancun, Beijing, 100190, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .; Pokaż więcej
Źródło:: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2018 May; Vol. 410 (14), pp. 3275-3284. Date of Electronic Publication: 2018 Feb 28.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Drug Evaluation, Preclinical/*methods
Receptor, Angiotensin, Type 1/*agonists
Receptor, Angiotensin, Type 1/*metabolism
Angiotensin II Type 1 Receptor Blockers/chemistry ; Cysteine/analogs & derivatives ; Cysteine/pharmacology ; HEK293 Cells ; Humans ; Ligands ; Microscopy, Atomic Force/methods ; Peptides/chemistry ; Peptides/pharmacology ; Spectrum Analysis/methods

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Skocz do pozycji: 12.

Tytuł:: A long-lasting oral preformulation of the angiotensin II AT1 receptor antagonist losartan.
Autorzy:: De Paula WX; a Laboratório de Encapsulamento Molecular e Biomateriais (LEMB), Chemistry Department, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
Denadai ÂML; b Laboratório de Nanotecnologia dos Fluidos Complexos, Pharmacy Department, Universidade Federal de Juiz de Fora (UFJF) , Valadares , MG , Brazil.
Braga ANG; c Biophysics and Physiology Department , Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
Shastri VP; d Department of Chemistry , Pharmacy, and Earth Sciences, Institute for Macromolecular Chemistry and BIOSS Centre for Biological Signalling Studies, University of Freiburg , Freiburg , Germany.
Pinheiro SVB; c Biophysics and Physiology Department , Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
Frezard F; c Biophysics and Physiology Department , Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
Santos RAS; c Biophysics and Physiology Department , Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
Sinisterra RD; a Laboratório de Encapsulamento Molecular e Biomateriais (LEMB), Chemistry Department, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.; Pokaż więcej
Źródło:: Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2018 Sep; Vol. 44 (9), pp. 1498-1505. Date of Electronic Publication: 2018 May 10.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*chemistry
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Receptor, Angiotensin, Type 1/*metabolism
Administration, Oral ; Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Chemistry, Pharmaceutical/methods ; Drug Carriers/chemistry ; Losartan ; Male ; Polymers/chemistry ; Rats ; Rats, Transgenic ; Rats, Wistar ; beta-Cyclodextrins/chemistry ; beta-Cyclodextrins/pharmacology

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Skocz do pozycji: 13.

Tytuł:: Atypical Kinetics and Albumin Effect of Glucuronidation of 5-n-Butyl-4-{4-[2-(1H-tetrazole-5- yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6- dichlorophenyl)-3H-1,2,4-triazol-3-one, a Novel Nonpeptide Angiotensin Type 1 Receptor Antagonist, in Liver Microsomes and UDP-Glucuronosyl-transferase.
Autorzy:: Peng Y; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Zhang X; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Zhu Y; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Wu H; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Gu S; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Chang Q; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Zhou Y; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Wang G; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .
Sun J; Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Pharmaceutical University China, Nanjing 210009, Jiangsu, China. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2018 Mar 19; Vol. 23 (3). Date of Electronic Publication: 2018 Mar 19.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Glucuronides/*metabolism
Glucuronosyltransferase/*metabolism
Microsomes, Liver/*metabolism
Pyrroles/*pharmacology
Receptor, Angiotensin, Type 1/*metabolism
Serum Albumin, Bovine/*metabolism
Triazoles/*pharmacology
Adult ; Aged ; Aged, 80 and over ; Angiotensin II Type 1 Receptor Blockers/chemistry ; Animals ; Humans ; Isoenzymes/metabolism ; Kinetics ; Metabolome/drug effects ; Microsomes, Liver/drug effects ; Middle Aged ; Pyrroles/chemistry ; Recombinant Proteins/metabolism ; Triazoles/chemistry

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension.
Autorzy:: Alhusban A; Program in Clinical and Experimental Therapeutics- Charlie Norwood VA Medical Center and College of Pharmacy, University of Georgia, Augusta, Georgia, United States of America.; College of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Kozak A; Program in Clinical and Experimental Therapeutics- Charlie Norwood VA Medical Center and College of Pharmacy, University of Georgia, Augusta, Georgia, United States of America.
Pillai B; Program in Clinical and Experimental Therapeutics- Charlie Norwood VA Medical Center and College of Pharmacy, University of Georgia, Augusta, Georgia, United States of America.
Ahmed H; Program in Clinical and Experimental Therapeutics- Charlie Norwood VA Medical Center and College of Pharmacy, University of Georgia, Augusta, Georgia, United States of America.
Sayed MA; Program in Clinical and Experimental Therapeutics- Charlie Norwood VA Medical Center and College of Pharmacy, University of Georgia, Augusta, Georgia, United States of America.
Johnson MH; Departments of Biostatistics, Medical College of Georgia, Augusta University, Augusta, Georgia, Unites States of America.
Ishrat T; Program in Clinical and Experimental Therapeutics- Charlie Norwood VA Medical Center and College of Pharmacy, University of Georgia, Augusta, Georgia, United States of America.
Ergul A; Program in Clinical and Experimental Therapeutics- Charlie Norwood VA Medical Center and College of Pharmacy, University of Georgia, Augusta, Georgia, United States of America.; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States of America.
Fagan SC; Departments of Biostatistics, Medical College of Georgia, Augusta University, Augusta, Georgia, Unites States of America.; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Jun 22; Vol. 12 (6), pp. e0178867. Date of Electronic Publication: 2017 Jun 22 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Benzimidazoles/*pharmacology
Blood Vessels/*drug effects
Hypertension/*complications
Neuroprotective Agents/*pharmacology
Receptor, Angiotensin, Type 1/*metabolism
Stroke/*prevention & control
Tetrazoles/*pharmacology
Acute Disease ; Animals ; Biphenyl Compounds ; Blood Vessels/metabolism ; Blood Vessels/pathology ; Blood Vessels/physiopathology ; Brain-Derived Neurotrophic Factor/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Gene Expression Regulation/drug effects ; Male ; Nerve Growth Factors/metabolism ; Nitric Oxide Synthase Type I/metabolism ; Nitric Oxide Synthase Type III/antagonists & inhibitors ; Nitric Oxide Synthase Type III/metabolism ; Nogo Proteins/metabolism ; Oxidative Stress/drug effects ; Protein-Tyrosine Kinases/metabolism ; Rats ; Rats, Inbred SHR ; Reactive Nitrogen Species/metabolism ; Receptor, trkB ; Signal Transduction/drug effects ; Stroke/metabolism ; Stroke/pathology ; Stroke/physiopathology ; Unfolded Protein Response/drug effects