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Wyszukujesz frazę ""Receptor, Cannabinoid, CB1"" wg kryterium: Temat


Tytuł :
The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species.
Autorzy :
Borgan F; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
Beck K; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
Butler E; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
McCutcheon R; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
Veronese M; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Vernon A; Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
Howes OD; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK. .; Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. .; Psychiatric Imaging Group, Faculty of Medicine, MRC London Institute of Medical Sciences (LMS), Imperial College London, London, UK. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2019 Nov; Vol. 236 (11), pp. 3257-3270. Date of Electronic Publication: 2019 Jun 05.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
Journal Info :
Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl.) Subsets: MEDLINE
MeSH Terms :
Cognition/*drug effects
Cognition/*physiology
Dronabinol/*pharmacology
Memory/*drug effects
Memory/*physiology
Receptor, Cannabinoid, CB1/*physiology
Animals ; Cannabinoids/adverse effects ; Cannabinoids/pharmacology ; Cognition Disorders/chemically induced ; Cognition Disorders/diagnosis ; Dronabinol/adverse effects ; Humans ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Species Specificity ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
Autorzy :
Li X; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Peng Z; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Zhou Y; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Wang J; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Lin X; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Dong X; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Liu X; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Jiang J; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Jiang Y; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Li L; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China; Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Public Security Bureau, Shanghai 200083, China. Electronic address: .
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Źródło :
Toxicology Letters [Toxicol Lett] 2019 Oct 01; Vol. 313, pp. 77-90. Date of Electronic Publication: 2019 Jun 18.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol. Lett.
MeSH Terms :
Antipsychotic Agents/*toxicity
Apoptosis/*drug effects
Cannabinoid Receptor Agonists/*toxicity
Cannabinoid Receptor Antagonists/*toxicity
Cardiomyopathies/*chemically induced
Myocytes, Cardiac/*drug effects
Quetiapine Fumarate/*toxicity
Receptor, Cannabinoid, CB1/*agonists
Receptor, Cannabinoid, CB2/*antagonists & inhibitors
Animals ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Cardiotoxicity ; Cell Line ; Endocannabinoids/metabolism ; Male ; Mice, Inbred BALB C ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Necrosis ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
Autorzy :
Dvorácskó S; A Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvári krt. 62., 6726, Szeged, Hungary.
Keresztes A; A Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvári krt. 62., 6726, Szeged, Hungary.
Mollica A; Dipartimento di Farmacia, Università di Chieti-Pescara 'G. d'Annunzio', Via dei Vestini 31, 66100, Chieti, Italy.
Stefanucci A; Dipartimento di Farmacia, Università di Chieti-Pescara 'G. d'Annunzio', Via dei Vestini 31, 66100, Chieti, Italy.
Macedonio G; Dipartimento di Farmacia, Università di Chieti-Pescara 'G. d'Annunzio', Via dei Vestini 31, 66100, Chieti, Italy.
Pieretti S; Istituto Superiore di Sanità, Centro Nazionale Ricerca e Valutazione Preclinica e Clinica dei Farmaci, Viale Regina Elena 299, 00161, Rome, Italy.
Zádor F; Laboratory of Opioid Research, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvári krt. 62., 6726, Szeged, Hungary.
Walter FR; Biological Barriers Research Group, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Temesvári krt. 62., 6726, Szeged, Hungary.
Deli MA; Biological Barriers Research Group, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Temesvári krt. 62., 6726, Szeged, Hungary.
Kékesi G; Department of Physiology, Faculty of Medicine, University of Szeged, 6720, Szeged, Dóm tér 10., Hungary.
Bánki L; Department of Traumatology, Faculty of Medicine, University of Szeged, 6725, Szeged, Semmelweis u. 6., Hungary.
Tuboly G; Department of Neurology, Faculty of Medicine, University of Szeged, 6725, Szeged, Semmelweis u. 6., Hungary.
Horváth G; Department of Physiology, Faculty of Medicine, University of Szeged, 6720, Szeged, Dóm tér 10., Hungary.
Tömböly C; A Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvári krt. 62., 6726, Szeged, Hungary. Electronic address: .
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Źródło :
European Journal Of Medicinal Chemistry [Eur J Med Chem] 2019 Sep 15; Vol. 178, pp. 571-588. Date of Electronic Publication: 2019 May 21.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
MeSH Terms :
Analgesics, Opioid/*pharmacology
Enkephalins/*pharmacology
Indoles/*pharmacology
Naphthalenes/*pharmacology
Oxycodone/*pharmacology
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Receptor, Cannabinoid, CB2/*antagonists & inhibitors
Receptors, Opioid, mu/*antagonists & inhibitors
Analgesics, Opioid/chemical synthesis ; Analgesics, Opioid/chemistry ; Animals ; Dose-Response Relationship, Drug ; Enkephalins/chemistry ; Indoles/chemistry ; Mice ; Molecular Structure ; Naphthalenes/chemistry ; Oxycodone/chemistry ; Rats ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Receptors, Opioid, mu/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Opposing roles of dorsomedial hypothalamic CB1 and TRPV1 receptors in anandamide signaling during the panic-like response elicited in mice by Brazilian rainbow Boidae snakes.
Autorzy :
Dos Anjos-Garcia T; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.; NAP-USP-Neurobiology of Emotions Research Centre (NuPNE), Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.; Ophidiarium LNN-FMRP-USP/INeC, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Coimbra NC; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. .; NAP-USP-Neurobiology of Emotions Research Centre (NuPNE), Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. .; Ophidiarium LNN-FMRP-USP/INeC, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. .; Behavioural Neuroscience Institute (INeC), Av. do Café, 2450, Ribeirão Preto, São Paulo, 14050-220, Brazil. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2019 Jun; Vol. 236 (6), pp. 1863-1874. Date of Electronic Publication: 2019 Jan 29.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl.) Subsets: MEDLINE
MeSH Terms :
Arachidonic Acids/*administration & dosage
Cannabinoid Receptor Agonists/*administration & dosage
Dorsomedial Hypothalamic Nucleus/*metabolism
Endocannabinoids/*administration & dosage
Panic/*physiology
Polyunsaturated Alkamides/*administration & dosage
Receptor, Cannabinoid, CB1/*biosynthesis
TRPV Cation Channels/*biosynthesis
Animals ; Boidae ; Brazil ; Dorsomedial Hypothalamic Nucleus/drug effects ; Dose-Response Relationship, Drug ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred C57BL ; Panic/drug effects ; Piperidines/administration & dosage ; Pyrazoles/administration & dosage ; Rats ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; TRPV Cation Channels/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease.
Autorzy :
Martínez-Pinilla E; Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Julián Clavería s/n, 33006, Oviedo, Asturias, Spain. .; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Asturias, Spain. .; Instituto de Salud del Principado de Asturias (ISPA), Oviedo, Asturias, Spain. .
Aguinaga D; Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Diagonal 643, Prevosti Building, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona. IBUB, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Navarro G; Institut de Biomedicina de la Universitat de Barcelona. IBUB, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Rico AJ; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Neurosciences Division, Centre for Applied Medical Research, CIMA, University of Navarra, Avenida Pío XII, 55, 31008, Pamplona, Spain.; Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
Oyarzábal J; Small Molecule Discovery Platform, Molecular Therapeutics Program, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Sánchez-Arias JA; Small Molecule Discovery Platform, Molecular Therapeutics Program, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Lanciego JL; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. .; Neurosciences Division, Centre for Applied Medical Research, CIMA, University of Navarra, Avenida Pío XII, 55, 31008, Pamplona, Spain. .; Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain. .
Franco R; Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Diagonal 643, Prevosti Building, 08028, Barcelona, Spain. .; Institut de Biomedicina de la Universitat de Barcelona. IBUB, Barcelona, Spain. .; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. .
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Źródło :
Molecular Neurobiology [Mol Neurobiol] 2019 Aug; Vol. 56 (8), pp. 5900-5910. Date of Electronic Publication: 2019 Jan 28.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol. Neurobiol. Subsets: MEDLINE
MeSH Terms :
Molecular Targeted Therapy*
Neuroprotective Agents/*therapeutic use
Parkinson Disease/*drug therapy
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Cell Line, Tumor ; Humans ; Ligands ; Models, Biological ; Neuroprotection/drug effects ; Neuroprotective Agents/pharmacology ; Oxygen Consumption/drug effects ; Receptor, Cannabinoid, CB1/metabolism ; Receptors, Cannabinoid/metabolism
Czasopismo naukowe
Tytuł :
Functional characterization of the cannabinoid receptors 1 and 2 in zebrafish larvae using behavioral analysis.
Autorzy :
Luchtenburg FJ; Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Schaaf MJM; Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Richardson MK; Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2019 Jul; Vol. 236 (7), pp. 2049-2058. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl.) Subsets: MEDLINE
MeSH Terms :
Dark Adaptation/*physiology
Larva/*metabolism
Locomotion/*physiology
Receptor, Cannabinoid, CB1/*physiology
Receptor, Cannabinoid, CB2/*physiology
Zebrafish Proteins/*physiology
Animals ; Arachidonic Acids/pharmacology ; Cannabinoids/pharmacology ; Dark Adaptation/drug effects ; Dose-Response Relationship, Drug ; Endocannabinoids/pharmacology ; Glycerides/pharmacology ; Larva/drug effects ; Locomotion/drug effects ; Piperidines/pharmacology ; Polyunsaturated Alkamides/pharmacology ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB2/agonists ; Zebrafish ; Zebrafish Proteins/agonists
Czasopismo naukowe
Tytuł :
Role of Endocannabinoid System in the Peripheral Antinociceptive Action of Aripiprazole.
Autorzy :
Ferreira RCM; From the Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Almeida-Santos AF
Duarte IDG
Aguiar DC
Moreira FA
Romero TRL
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Źródło :
Anesthesia And Analgesia [Anesth Analg] 2019 Jul; Vol. 129 (1), pp. 263-268.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1310650 Publication Model: Print Cited Medium: Internet ISSN: 1526-7598 (Electronic) Linking ISSN: 00032999 NLM ISO Abbreviation: Anesth. Analg. Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Analgesics/*pharmacology
Aripiprazole/*pharmacology
Cannabinoid Receptor Agonists/*pharmacology
Endocannabinoids/*metabolism
Hyperalgesia/*prevention & control
Nociceptive Pain/*prevention & control
Receptor, Cannabinoid, CB1/*agonists
Receptor, Cannabinoid, CB2/*agonists
Animals ; Dinoprostone ; Disease Models, Animal ; Hyperalgesia/chemically induced ; Hyperalgesia/metabolism ; Hyperalgesia/physiopathology ; Male ; Mice ; Nociceptive Pain/chemically induced ; Nociceptive Pain/metabolism ; Nociceptive Pain/physiopathology ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Divergent Response to Cannabinoid Receptor Stimulation in High and Low Stress-Induced Analgesia Mouse Lines Is Associated with Differential G-Protein Activation.
Autorzy :
Lesniak A; Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Warsaw, Poland. Electronic address: .
Chmielewska D; Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Warsaw, Poland.
Poznanski P; Laboratory of Neurogenomics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland.
Bujalska-Zadrozny M; Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Warsaw, Poland.
Strzemecka J; Institute of Health Sciences, Pope John Paul II State School of Higher Education, Biala Podlaska, Poland.
Sacharczuk M; Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Warsaw, Poland; Laboratory of Neurogenomics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland; Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.
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Źródło :
Neuroscience [Neuroscience] 2019 Apr 15; Vol. 404, pp. 246-258. Date of Electronic Publication: 2019 Feb 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
MeSH Terms :
Brain/*physiology
Pain/*genetics
Receptor, Cannabinoid, CB1/*genetics
Receptor, Cannabinoid, CB2/*genetics
Stress, Psychological/*genetics
Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Brain/drug effects ; GTP-Binding Proteins/agonists ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism ; Mice ; Pain/drug therapy ; Pain/metabolism ; Pain Measurement/drug effects ; Pain Measurement/methods ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/metabolism ; Species Specificity ; Stress, Psychological/metabolism
Czasopismo naukowe
Tytuł :
Structural Insights into CB1 Receptor Biased Signaling.
Autorzy :
Al-Zoubi R; Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science & Technology, P.O.BOX 3030, Irbid 22110, Jordan. .
Morales P; Departamento de Química-Física Biológica, Instituto de Química Física Rocasolano (IQFR-CSIC), Serrano 119, 28006 Madrid, Spain. .
Reggio PH; Chemistry and Biochemistry Department, UNC Greensboro, Greensboro, NC 27412, USA. .
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Źródło :
International Journal Of Molecular Sciences [Int J Mol Sci] 2019 Apr 13; Vol. 20 (8). Date of Electronic Publication: 2019 Apr 13.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci
MeSH Terms :
Protein Conformation*
Signal Transduction*
Receptor, Cannabinoid, CB1/*chemistry
Receptor, Cannabinoid, CB1/*metabolism
Animals ; Humans ; Ligands ; Mutation ; Phosphorylation ; Protein Binding ; Protein Interaction Domains and Motifs ; Receptor, Cannabinoid, CB1/genetics ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Identification of novel mouse and rat CB1R isoforms and in silico modeling of human CB1R for peripheral cannabinoid therapeutics.
Autorzy :
Liu QR; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA. .
Huang NS; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA.
Qu H; Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China.
O'Connell JF; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA.
Gonzalez-Mariscal I; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA.
Santa-Cruz-Calvo S; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA.
Doyle ME; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA.
Xi ZX; Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, USA.
Wang Y; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.
Onaivi ES; Department of Biology, William Paterson University, Wayne, NJ, USA.
Egan JM; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA.
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Źródło :
Acta Pharmacologica Sinica [Acta Pharmacol Sin] 2019 Mar; Vol. 40 (3), pp. 387-397. Date of Electronic Publication: 2018 Sep 10.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol. Sin. Subsets: MEDLINE
MeSH Terms :
Receptor, Cannabinoid, CB1/*genetics
Receptor, Cannabinoid, CB1/*metabolism
Amino Acid Sequence ; Animals ; Arachidonic Acids/chemistry ; Cannabinoid Receptor Agonists/chemistry ; Cerebral Cortex/metabolism ; Endocannabinoids/chemistry ; Exons ; Glycerides/chemistry ; Humans ; Male ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Promoter Regions, Genetic ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Pyrazoles/chemistry ; Rats, Long-Evans ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/chemistry ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells
Autorzy :
Gholizadeh F; Department of Toxicology and Pharmacology, Faculty of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ghahremani MH; Department of Toxicology and Pharmacology, Faculty of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Aliebrahimi S; Department of Cellular and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Shadboorestan A; Department of Toxicology and Pharmacology, Faculty of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ostad SN; Department of Toxicology and Pharmacology, Faculty of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło :
Iranian Biomedical Journal [Iran Biomed J] 2019 Mar; Vol. 23 (2), pp. 153-8. Date of Electronic Publication: 2018 Jun 09.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Pasteur Institute of Iran Country of Publication: Iran NLM ID: 9814853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2008-823X (Electronic) Linking ISSN: 1028852X NLM ISO Abbreviation: Iran. Biomed. J. Subsets: MEDLINE
MeSH Terms :
Benzoxazines/*pharmacology
Cannabinoids/*pharmacology
Morpholines/*pharmacology
Naphthalenes/*pharmacology
Piperidines/*pharmacology
Pyrazoles/*pharmacology
Receptor, Cannabinoid, CB1/*agonists
Receptor, Cannabinoid, CB1/*analysis
Dose-Response Relationship, Drug ; Humans ; K562 Cells ; Neoplasm Invasiveness/pathology ; Receptor, Cannabinoid, CB1/metabolism
Czasopismo naukowe
Tytuł :
Role of microRNA in CB1 antagonist-mediated regulation of adipose tissue macrophage polarization and chemotaxis during diet-induced obesity.
Autorzy :
Mehrpouya-Bahrami P; From the Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208.
Miranda K; From the Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208.
Singh NP; From the Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208.
Zumbrun EE; From the Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208.
Nagarkatti M; From the Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208.
Nagarkatti PS; From the Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208 .
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Źródło :
The Journal Of Biological Chemistry [J Biol Chem] 2019 May 10; Vol. 294 (19), pp. 7669-7681. Date of Electronic Publication: 2019 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J. Biol. Chem. Subsets: MEDLINE
MeSH Terms :
Adipose Tissue/*metabolism
Chemotaxis/*drug effects
Dietary Fats/*adverse effects
Macrophages/*metabolism
MicroRNAs/*metabolism
Obesity/*metabolism
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Rimonabant/*pharmacology
Adipose Tissue/pathology ; Animals ; Dietary Fats/pharmacology ; Gene Expression Regulation/drug effects ; Kruppel-Like Transcription Factors/biosynthesis ; Macrophages/pathology ; Male ; Mice ; Obesity/chemically induced ; Obesity/drug therapy ; Receptor, Cannabinoid, CB1/metabolism ; STAT6 Transcription Factor/biosynthesis
Czasopismo naukowe
Tytuł :
Synergistic action of CB1 and 5-HT2B receptors in preventing pilocarpine-induced status epilepticus in rats.
Autorzy :
Colangeli R; Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. Electronic address: .
Di Maio R; Pittsburgh Inst. for Neurodegenerative Dis., Dept. of Neurology, Univ. of Pittsburgh, PA, USA.
Pierucci M; Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Deidda G; Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Casarrubea M; Department of Experimental Biomedicine and Clinical Neurosciences, Human Physiology Section 'Giuseppe Pagano', University of Palermo, Palermo, Italy.
Di Giovanni G; Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; School of Biosciences, Cardiff University, Cardiff, UK. Electronic address: .
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Źródło :
Neurobiology Of Disease [Neurobiol Dis] 2019 May; Vol. 125, pp. 135-145. Date of Electronic Publication: 2019 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol. Dis. Subsets: MEDLINE
MeSH Terms :
Receptor, Cannabinoid, CB1/*metabolism
Receptor, Serotonin, 5-HT2B/*metabolism
Status Epilepticus/*metabolism
Animals ; Benzoxazines/pharmacology ; Calcium Channel Blockers/pharmacology ; Male ; Morpholines/pharmacology ; Muscarinic Agonists/toxicity ; Naphthalenes/pharmacology ; Pilocarpine/toxicity ; Rats ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/drug effects ; Receptor, Serotonin, 5-HT2B/drug effects ; Serotonin 5-HT2 Receptor Agonists/pharmacology ; Status Epilepticus/chemically induced
Czasopismo naukowe
Tytuł :
Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Autorzy :
Navarro-Romero A; Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.
Vázquez-Oliver A; Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.
Gomis-González M; Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.
Garzón-Montesinos C; Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cell Biology, University Pablo de Olavide, Ctra Utrera km. 1, 41013 Seville, Spain.
Falcón-Moya R; Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cell Biology, University Pablo de Olavide, Ctra Utrera km. 1, 41013 Seville, Spain.
Pastor A; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain; CIBER Pathophysiology of Obesity and Nutrition, Institute of Health Carlos III, 28029 Madrid, Spain.
Martín-García E; Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain.
Pizarro N; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain.
Busquets-Garcia A; Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.
Revest JM; INSERM U1215, Neurocentre Magendie, Physiopathology and Therapeutic Approaches of Stress-Related Diseases, 33077 Bordeaux, France.
Piazza PV; INSERM U1215, Neurocentre Magendie, Physiopathology and Therapeutic Approaches of Stress-Related Diseases, 33077 Bordeaux, France.
Bosch F; Center of Animal Biotechnology and Gene Therapy (CBATEG), Spain; Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain; CIBER Diabetes and Associated Metabolic Disorders (CIBERDEM), 08017 Madrid, Spain.
Dierssen M; Cellular & Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; CIBER Rare Disorders (CIBERER), Spain; Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain.
de la Torre R; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain; CIBER Pathophysiology of Obesity and Nutrition, Institute of Health Carlos III, 28029 Madrid, Spain.
Rodríguez-Moreno A; Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cell Biology, University Pablo de Olavide, Ctra Utrera km. 1, 41013 Seville, Spain.
Maldonado R; Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.
Ozaita A; Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain. Electronic address: .
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Źródło :
Neurobiology Of Disease [Neurobiol Dis] 2019 May; Vol. 125, pp. 92-106. Date of Electronic Publication: 2019 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol. Dis. Subsets: MEDLINE
MeSH Terms :
Brain/*drug effects
Cannabinoid Receptor Antagonists/*pharmacology
Cognition/*drug effects
Down Syndrome/*metabolism
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Animals ; Brain/metabolism ; Cognitive Dysfunction/genetics ; Disease Models, Animal ; Female ; Male ; Mice ; Mice, Transgenic ; Neurogenesis/drug effects ; Phenotype ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/drug effects ; Rimonabant/pharmacology
Czasopismo naukowe
Tytuł :
Development of Oxygen-Bridged Pyrazole-Based Structures as Cannabinoid Receptor 1 Ligands.
Autorzy :
Murineddu G; Department of Chemistry and Pharmacy, University of Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy. .
Asproni B; Department of Chemistry and Pharmacy, University of Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy. .
Corona P; Department of Chemistry and Pharmacy, University of Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy. .
Piras S; Department of Chemistry and Pharmacy, University of Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy. .
Lazzari P; KemoTech SrL, Build 3, Loc. Piscinamanna, 09010 Pula, Italy. .
Ruiu S; National Research Council (C.N.R.)-Institute of Translational Pharmacology, U.O.S. of Cagliari, Science and Technology Park of Sardinia Polaris, 09010 Pula, Italy. .
Legnani L; Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. .
Toma L; Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy. .
Pinna GA; Department of Chemistry and Pharmacy, University of Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy. .
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Apr 27; Vol. 24 (9). Date of Electronic Publication: 2019 Apr 27.
Typ publikacji :
Journal Article
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules
MeSH Terms :
Drug Development*
Oxygen/*chemistry
Pyrazoles/*chemistry
Receptor, Cannabinoid, CB1/*chemistry
Animals ; Biomarkers ; Cell Line ; Dose-Response Relationship, Drug ; Ligands ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Models, Molecular ; Molecular Structure ; Organ Specificity/drug effects ; Phosphorylation/drug effects ; Protein Binding ; Pyrazoles/chemical synthesis ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Ketamine induces central antinociception mediated by endogenous cannabinoids and activation of CB1 receptors.
Autorzy :
Pacheco DDF; Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. Antônio Carlos, 6627, 31.270.100, Belo Horizonte, Brazil. Electronic address: .
Romero TRL; Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. Antônio Carlos, 6627, 31.270.100, Belo Horizonte, Brazil. Electronic address: .
Duarte IDG; Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. Antônio Carlos, 6627, 31.270.100, Belo Horizonte, Brazil. Electronic address: .
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Źródło :
Neuroscience Letters [Neurosci Lett] 2019 Apr 23; Vol. 699, pp. 140-144. Date of Electronic Publication: 2019 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci. Lett. Subsets: MEDLINE
MeSH Terms :
Analgesics/*pharmacology
Cannabinoids/*metabolism
Ketamine/*pharmacology
Receptor, Cannabinoid, CB1/*agonists
Animals ; Arachidonic Acids/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Indoles/pharmacology ; Infusions, Intraventricular ; Ketamine/administration & dosage ; Ketamine/antagonists & inhibitors ; Male ; Mice ; Organophosphonates/pharmacology ; Pain Measurement/drug effects ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Mice Missing Cnr1 and Cnr2 Show Implantation Defects.
Autorzy :
Li Y; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Bian F; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Sun X; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Dey SK; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
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Źródło :
Endocrinology [Endocrinology] 2019 Apr 01; Vol. 160 (4), pp. 938-946.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Embryo Implantation/*genetics
Infertility, Female/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Receptor, Cannabinoid, CB2/*metabolism
Uterus/*metabolism
Animals ; Female ; Infertility, Female/genetics ; Mice ; Mice, Knockout ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB2/genetics ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Cannabinoid Receptor Type 1 Agonist ACEA Improves Cognitive Deficit on STZ-Induced Neurotoxicity Through Apoptosis Pathway and NO Modulation.
Autorzy :
Crunfli F; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil. .
Vrechi TA; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Costa AP; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Torrão AS; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
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Źródło :
Neurotoxicity Research [Neurotox Res] 2019 Apr; Vol. 35 (3), pp. 516-529. Date of Electronic Publication: 2019 Jan 03.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE
MeSH Terms :
Arachidonic Acids/*pharmacology
Cannabinoid Receptor Agonists/*pharmacology
Cognition Disorders/*drug therapy
Neuroprotective Agents/*pharmacology
Nootropic Agents/*pharmacology
Receptor, Cannabinoid, CB1/*agonists
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Cognition Disorders/metabolism ; Male ; Mice ; Nerve Degeneration/drug therapy ; Nerve Degeneration/metabolism ; Nitric Oxide/metabolism ; Rats, Wistar ; Receptor, Cannabinoid, CB1/metabolism ; Streptozocin
Czasopismo naukowe
Tytuł :
A patent update on cannabinoid receptor 1 antagonists (2015-2018).
Autorzy :
Amato G; a Center for Drug Discovery , RTI International , RTP , NC , USA.
Khan NS; a Center for Drug Discovery , RTI International , RTP , NC , USA.
Maitra R; a Center for Drug Discovery , RTI International , RTP , NC , USA.
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Źródło :
Expert Opinion On Therapeutic Patents [Expert Opin Ther Pat] 2019 Apr; Vol. 29 (4), pp. 261-269. Date of Electronic Publication: 2019 Apr 08.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Informa Healthcare Country of Publication: England NLM ID: 9516419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7674 (Electronic) Linking ISSN: 13543776 NLM ISO Abbreviation: Expert Opin Ther Pat Subsets: MEDLINE
MeSH Terms :
Cannabinoid Receptor Antagonists/*pharmacology
Endocannabinoids/*metabolism
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Animals ; Cannabinoid Receptor Antagonists/immunology ; Drug Development/methods ; Humans ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/physiopathology ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/physiopathology ; Obesity/drug therapy ; Obesity/physiopathology ; Patents as Topic ; Receptor, Cannabinoid, CB1/metabolism
Czasopismo naukowe
Tytuł :
Additive effect of 5-HT2C and CB1 receptor blockade on the regulation of sleep-wake cycle.
Autorzy :
Bogáthy E; Department of Pharmacodynamics, Semmelweis University, Budapest, Nagyvárad tér 4, 1089, Hungary.
Papp N; Department of Pharmacodynamics, Semmelweis University, Budapest, Nagyvárad tér 4, 1089, Hungary.
Tóthfalusi L; Department of Pharmacodynamics, Semmelweis University, Budapest, Nagyvárad tér 4, 1089, Hungary.
Vas S; Department of Pharmacodynamics, Semmelweis University, Budapest, Nagyvárad tér 4, 1089, Hungary.; MTA-SE, Neuropsychopharmacology and Neurochemistry Research Group, Budapest, 1089, Hungary.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK.
Bagdy G; Department of Pharmacodynamics, Semmelweis University, Budapest, Nagyvárad tér 4, 1089, Hungary. .; MTA-SE, Neuropsychopharmacology and Neurochemistry Research Group, Budapest, 1089, Hungary. .; NAP-A-SE, New Antidepressant Target Research Group, Budapest, 1089, Hungary. .; NAP-2-SE, New Antidepressant Target Research Group, Budapest, 1089, Hungary. .
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Źródło :
BMC Neuroscience [BMC Neurosci] 2019 Mar 20; Vol. 20 (1), pp. 14. Date of Electronic Publication: 2019 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: BioMed Central Country of Publication: England NLM ID: 100966986 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2202 (Electronic) Linking ISSN: 14712202 NLM ISO Abbreviation: BMC Neurosci
MeSH Terms :
Cannabinoid Receptor Antagonists/*pharmacology
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Serotonin 5-HT2 Receptor Antagonists/*pharmacology
Sleep/*drug effects
Wakefulness/*drug effects
Wakefulness-Promoting Agents/*pharmacology
Aminopyridines/pharmacology ; Animals ; Drug Synergism ; Electroencephalography ; Electromyography ; Indoles/pharmacology ; Male ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Rats, Wistar ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Serotonin, 5-HT2C/metabolism ; Sleep/physiology ; Wakefulness/physiology
Czasopismo naukowe

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