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Wyszukujesz frazę ""Receptor, Cannabinoid, CB1"" wg kryterium: Temat


Tytuł :
Incerta-thalamic Circuit Controls Nocifensive Behavior via Cannabinoid Type 1 Receptors.
Autorzy :
Wang H; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Anesthesiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Dong P; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
He C; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Feng XY; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Huang Y; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yang WW; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Gao HJ; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Shen XF; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Lin S; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Cao SX; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Lian H; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chen J; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yan M; Department of Anesthesiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Li XM; Center for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Joint Institute for Genetics and Genome Medicine between Zhejiang University and University of Toronto, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Aug 05; Vol. 107 (3), pp. 538-551.e7. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
Journal Info :
Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
MeSH Terms :
Neurons/*physiology
Nociception/*physiology
Pain/*physiopathology
Posterior Thalamic Nuclei/*physiology
Receptor, Cannabinoid, CB1/*metabolism
Zona Incerta/*physiology
Animals ; Behavior, Animal ; Endocannabinoids ; Mice ; Neural Inhibition ; Neural Pathways ; Neurons/metabolism ; Pain/metabolism ; Parvalbumins ; Posterior Thalamic Nuclei/cytology ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Zona Incerta/cytology
Czasopismo naukowe
Tytuł :
Glucose metabolism links astroglial mitochondria to cannabinoid effects.
Autorzy :
Jimenez-Blasco D; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Busquets-Garcia A; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.; Integrative Pharmacology and Systems Neuroscience, IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain.
Hebert-Chatelain E; Canada Research Chair in Mitochondrial Signaling and Physiopathology, Université de Moncton, Moncton, New Brunswick, Canada.; Department of Biology, Université de Moncton, Moncton, New Brunswick, Canada.
Serrat R; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Vicente-Gutierrez C; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Ioannidou C; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Gómez-Sotres P; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Lopez-Fabuel I; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Resch-Beusher M; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Resel E; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación Neuroquímica (IUIN) and Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Arnouil D; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Saraswat D; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Varilh M; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Cannich A; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Julio-Kalajzic F; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Bonilla-Del Río I; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Almeida A; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Puente N; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Achicallende S; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Lopez-Rodriguez ML; Department of Organic Chemistry, Complutense University, Madrid, Spain.
Jollé C; Department of Physiology, University of Lausanne, Lausanne, Switzerland.
Déglon N; Department of Clinical Neurosciences, Laboratory of Cellular and Molecular Neurotherapies (LCMN), University of Lausanne, Lausanne, Switzerland.
Pellerin L; Department of Physiology, University of Lausanne, Lausanne, Switzerland.; Centre de Résonance Magnétique des Systèmes Biologiques UMR 5536, CNRS-University of Bordeaux, Bordeaux, France.; INSERM U1082, University of Poitiers, Poitiers, France.
Josephine C; Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.
Bonvento G; Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.
Panatier A; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Lutz B; Institute of Physiological Chemistry, University Medical Center, Mainz, Germany.; Leibniz Institute for Resilience Research (LIR), Mainz, Germany.
Piazza PV; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.; Aelis Farma, Bordeaux, France.
Guzmán M; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación Neuroquímica (IUIN) and Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Bellocchio L; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Bouzier-Sore AK; Centre de Résonance Magnétique des Systèmes Biologiques UMR 5536, CNRS-University of Bordeaux, Bordeaux, France.
Grandes P; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
Bolaños JP; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain. .; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. .; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain. .
Marsicano G; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France. .; University of Bordeaux, Bordeaux, France. .
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Źródło :
Nature [Nature] 2020 Jul; Vol. 583 (7817), pp. 603-608. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
MeSH Terms :
Energy Metabolism*/drug effects
Astrocytes/*metabolism
Glucose/*metabolism
Mitochondria/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Animals ; Astrocytes/cytology ; Astrocytes/drug effects ; Cannabinoid Receptor Agonists/pharmacology ; Cells, Cultured ; Dronabinol/pharmacology ; Electron Transport Complex I/chemistry ; Electron Transport Complex I/metabolism ; Glycolysis/drug effects ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Lactic Acid/metabolism ; Male ; Mice ; Mitochondria/drug effects ; Mitochondrial Membranes/metabolism ; Oxidation-Reduction ; Phosphorylation ; Reactive Oxygen Species/metabolism ; Receptor, Cannabinoid, CB1/agonists ; Social Behavior
Czasopismo naukowe
Tytuł :
Cannabinoid Signaling Selectively Modulates GABAergic Inhibitory Input to OFF Bipolar Cells in Rat Retina.
Autorzy :
Vielma AH
Tapia F
Alcaino A
Fuenzalida M; .
Schmachtenberg O
Chávez AE
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Mar 09; Vol. 61 (3), pp. 3.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Subsets: MEDLINE
MeSH Terms :
Receptor, Cannabinoid, CB1/*physiology
Retinal Bipolar Cells/*physiology
Amacrine Cells/metabolism ; Amacrine Cells/physiology ; Animals ; Benzoxazines/pharmacology ; Cell Polarity/drug effects ; Cell Polarity/physiology ; Endocannabinoids/metabolism ; Feedback, Physiological/drug effects ; Feedback, Physiological/physiology ; Female ; GABA-A Receptor Antagonists/pharmacology ; Glutamic Acid/pharmacology ; Inhibitory Postsynaptic Potentials/drug effects ; Inhibitory Postsynaptic Potentials/physiology ; Male ; Morpholines/pharmacology ; Naphthalenes/pharmacology ; Patch-Clamp Techniques/methods ; Phosphinic Acids/pharmacology ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/drug effects ; Retina ; Retinal Bipolar Cells/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Hydrodynamics-based liver transfection achieves gene silencing of CB1 using short hairpin RNA plasmid in cirrhotic rats.
Autorzy :
Díaz-Rivera A; Institute of Molecular Biology in Medicine, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Meza-Ríos A; Tecnologico de Monterrey, Campus Guadalajara, Guadalajara, Mexico.
Chagoya de Sánchez V; Cellular Physiology Institute, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Velasco-Loyden G; Cellular Physiology Institute, Universidad Nacional Autónoma de México, Mexico City, Mexico.
García-Benavides L; Biomedical Sciences Department, Centro Universitario de Tonala, Universidad de Guadalajara, Tonala, Mexico.
Jave-Suarez LF; Immunology Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social.
Monroy-Ramirez HC; Institute of Molecular Biology in Medicine, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Santos-García A; Tecnologico de Monterrey, Campus Guadalajara, Guadalajara, Mexico.
Armendáriz-Borunda J; Institute of Molecular Biology in Medicine, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.; Tecnologico de Monterrey, Campus Guadalajara, Guadalajara, Mexico.
Sandoval-Rodríguez A; Institute of Molecular Biology in Medicine, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
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Źródło :
PloS one [PLoS One] 2020 Feb 13; Vol. 15 (2), pp. e0228729. Date of Electronic Publication: 2020 Feb 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS ONE Subsets: MEDLINE
MeSH Terms :
Gene Silencing*
Hydrodynamics*
Liver Cirrhosis/*pathology
RNA, Small Interfering/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Actins/genetics ; Actins/metabolism ; Alanine Transaminase/blood ; Alanine Transaminase/metabolism ; Animals ; Aspartate Aminotransferases/blood ; Aspartate Aminotransferases/metabolism ; Brain/metabolism ; Cells, Cultured ; Disease Models, Animal ; Hepatic Stellate Cells/cytology ; Hepatic Stellate Cells/metabolism ; Liver/metabolism ; Male ; Plasmids/metabolism ; RNA, Small Interfering/administration & dosage ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/genetics ; Transfection ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB 1 receptor in the ventromedial hypothalamus.
Autorzy :
Khan AU; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.; Department of Eastern Medicine and Surgery, School of Medical and Health Sciences, The University of Poonch Rawalakot, Hajira Road, Shamsabad, Rawalakot, Azad Jammu & Kashmir, 12350, Pakistan.; Neurobiology of Emotions (NAP-USP-NuPNE) Research Centre, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Falconi-Sobrinho LL; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.; Neurobiology of Emotions (NAP-USP-NuPNE) Research Centre, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.; Behavioural Neurosciences Institute (INeC), Avenida do Café, 2450, Ribeirão Preto, São Paulo, 4220-030, Brazil.
Dos Anjos-Garcia T; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.; Neurobiology of Emotions (NAP-USP-NuPNE) Research Centre, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
de Fátima Dos Santos Sampaio M; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
de Souza Crippa JA; Department of Neuroscience and Behavioural Sciences, Division of Psychiatry, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Menescal-de-Oliveira L; Neurobiology of Emotions (NAP-USP-NuPNE) Research Centre, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.; Laboratory of Neurophysiology, Department of Physiology, Ribeirão Preto Medical School of the University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Coimbra NC; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. .; Neurobiology of Emotions (NAP-USP-NuPNE) Research Centre, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. .; Behavioural Neurosciences Institute (INeC), Avenida do Café, 2450, Ribeirão Preto, São Paulo, 4220-030, Brazil. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Apr; Vol. 237 (4), pp. 1063-1079. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl.) Subsets: MEDLINE
MeSH Terms :
Cannabidiol/*toxicity
Fear/*physiology
Pain Measurement/*methods
Panic Disorder/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Ventromedial Hypothalamic Nucleus/*metabolism
Animals ; Cannabidiol/administration & dosage ; Fear/drug effects ; Fear/psychology ; Injections, Intraventricular ; Male ; N-Methylaspartate/administration & dosage ; Pain Measurement/drug effects ; Pain Measurement/psychology ; Panic Disorder/chemically induced ; Piperidines/administration & dosage ; Pyrazoles/administration & dosage ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Ventromedial Hypothalamic Nucleus/drug effects
Czasopismo naukowe
Tytuł :
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G i Complex Structures.
Autorzy :
Hua T; iHuman Institute, ShanghaiTech University, Shanghai 201210, China. Electronic address: .
Li X; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Wu L; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Iliopoulos-Tsoutsouvas C; Center for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Wang Y; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Wu M; iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Shen L; iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Johnston CA; Departments of Molecular Medicine and Neuroscience, Scripps Research, Jupiter, FL 33458, USA.
Nikas SP; Center for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Song F; School of Life Science, Dezhou University, Dezhou 253023, Shandong Province, China.
Song X; Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Yuan S; The Research Center for Computer-aided Drug Discovery, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Sun Q; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Wu Y; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Jiang S; Center for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Grim TW; Departments of Molecular Medicine and Neuroscience, Scripps Research, Jupiter, FL 33458, USA.
Benchama O; Center for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Stahl EL; Departments of Molecular Medicine and Neuroscience, Scripps Research, Jupiter, FL 33458, USA.
Zvonok N; Center for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Zhao S; iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Bohn LM; Departments of Molecular Medicine and Neuroscience, Scripps Research, Jupiter, FL 33458, USA.
Makriyannis A; Center for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; Center for Drug Discovery and Departments of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Liu ZJ; iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming 650500, Yunnan Province, China. Electronic address: .
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Źródło :
Cell [Cell] 2020 Feb 20; Vol. 180 (4), pp. 655-665.e18. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
MeSH Terms :
Signal Transduction*
Cannabinoid Receptor Agonists/*pharmacology
GTP-Binding Protein alpha Subunits, Gi-Go/*chemistry
Receptor, Cannabinoid, CB1/*chemistry
Receptor, Cannabinoid, CB2/*chemistry
Allosteric Regulation ; Allosteric Site ; Animals ; CHO Cells ; Cannabinoid Receptor Agonists/chemistry ; Cannabinoids/chemistry ; Cannabinoids/pharmacology ; Cell Line, Tumor ; Cholesterol/chemistry ; Cholesterol/pharmacology ; Cricetinae ; Cricetulus ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; Humans ; Molecular Dynamics Simulation ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Sf9 Cells ; Spodoptera
Czasopismo naukowe
Tytuł :
Allosteric modulators restore orthosteric agonist binding to mutated CB 1 receptors.
Autorzy :
Dopart R; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
Kendall DA; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2020 Jan; Vol. 72 (1), pp. 84-91. Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Wiley Country of Publication: England NLM ID: 0376363 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-7158 (Electronic) Linking ISSN: 00223573 NLM ISO Abbreviation: J. Pharm. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Cannabinoid Receptor Agonists/*pharmacology
Cyclohexanols/*pharmacology
Indoles/*pharmacology
Phenylurea Compounds/*pharmacology
Piperidines/*pharmacology
Pyridines/*pharmacology
Receptor, Cannabinoid, CB1/*agonists
Rimonabant/*pharmacology
Binding Sites ; Cannabinoid Receptor Agonists/metabolism ; Cyclohexanols/metabolism ; HEK293 Cells ; Humans ; Indoles/metabolism ; Ligands ; Mutation ; Phenylurea Compounds/metabolism ; Piperidines/metabolism ; Protein Binding ; Protein Conformation ; Pyridines/metabolism ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB1/metabolism ; Rimonabant/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos.
Autorzy :
Zuccarini G; Department of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy.; Department of Molecular Biotechnologies and Health Sciences, University of Torino, 10126 Torino, Italy.
D'Atri I; Department of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy.; Department of Molecular Biotechnologies and Health Sciences, University of Torino, 10126 Torino, Italy.; Wellcome Wolfson Centre for Medical Research, University of Exeter, Exeter EX2 5DW, UK.
Cottone E; Department of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy.
Mackie K; Department of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405, USA.
Shainer I; Department of Neurobiology, The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 6997801, Israel.
Gothilf Y; Department of Neurobiology, The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 6997801, Israel.
Provero P; Department of Molecular Biotechnologies and Health Sciences, University of Torino, 10126 Torino, Italy.
Bovolin P; Department of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy.
Merlo GR; Department of Molecular Biotechnologies and Health Sciences, University of Torino, 10126 Torino, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 25; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 25.
Typ publikacji :
Journal Article
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
MeSH Terms :
Agouti-Related Protein/*metabolism
Axons/*metabolism
Gonadotropin-Releasing Hormone/*metabolism
Pyrrolidonecarboxylic Acid/*analogs & derivatives
Receptor, Cannabinoid, CB1/*metabolism
Zebrafish/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Benzoxazines/pharmacology ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/metabolism ; Embryonic Development/drug effects ; Morpholines/pharmacology ; Morpholinos/metabolism ; Naphthalenes/pharmacology ; Neurons/drug effects ; Neurons/metabolism ; Pyrrolidonecarboxylic Acid/metabolism ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/genetics ; Zebrafish/growth & development ; Zebrafish Proteins/antagonists & inhibitors ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis.
Autorzy :
Suárez J; Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain. Electronic address: .
Rivera P; Department of Endocrinology, Fundación Investigación Biomédica del Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Aparisi Rey A; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.
Pérez-Martín M; Departamento de Biología Celular, Genética y Fisiología, IBIMA, Universidad de Málaga, Málaga, Spain.
Arrabal S; Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain.
Rodríguez de Fonseca F; Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain.
Ruiz de Azua I; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany; German Resilience Center (DRZ), Mainz, Germany.
Lutz B; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany; German Resilience Center (DRZ), Mainz, Germany. Electronic address: .
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Źródło :
Psychoneuroendocrinology [Psychoneuroendocrinology] 2019 Dec; Vol. 110, pp. 104418. Date of Electronic Publication: 2019 Aug 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE
MeSH Terms :
Adipocytes/*metabolism
Depression/*genetics
Diet, High-Fat/*adverse effects
Memory Disorders/*etiology
Neuritis/*genetics
Neurogenesis/*genetics
Receptor, Cannabinoid, CB1/*genetics
Adult Stem Cells/physiology ; Animals ; Behavior, Animal/physiology ; Brain/cytology ; Brain/physiology ; Depression/metabolism ; Gene Deletion ; Male ; Memory Disorders/genetics ; Memory Disorders/metabolism ; Memory Disorders/psychology ; Mice ; Mice, Knockout ; Neural Stem Cells/physiology ; Neuritis/metabolism ; Neuritis/pathology ; Organ Specificity/genetics ; Receptor, Cannabinoid, CB1/deficiency ; Receptor, Cannabinoid, CB1/metabolism
Czasopismo naukowe
Tytuł :
Allosteric Modulation of Cannabinoid Receptor 1-Current Challenges and Future Opportunities.
Autorzy :
Hryhorowicz S; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.
Kaczmarek-Ryś M; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.
Andrzejewska A; Department of Structure and Function of Retrotransposons, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznań, Poland.
Staszak K; Department of Integrative Genomics, Institute of Anthropology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.
Hryhorowicz M; Department of Biochemistry and Biotechnology, University of Life Sciences, Dojazd 11, 60-632 Poznań, Poland.
Korcz A; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.
Słomski R; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.; Department of Biochemistry and Biotechnology, University of Life Sciences, Dojazd 11, 60-632 Poznań, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Nov 22; Vol. 20 (23). Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
MeSH Terms :
Receptor, Cannabinoid, CB1*/chemistry
Receptor, Cannabinoid, CB1*/genetics
Receptor, Cannabinoid, CB1*/metabolism
Cannabinoid Receptor Agonists/*chemistry
Allosteric Regulation ; Animals ; Cannabinoid Receptor Agonists/therapeutic use ; Crystallography, X-Ray ; Humans ; Mutagenesis, Site-Directed ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Pain/drug therapy ; Pain/genetics ; Pain/metabolism ; Structure-Activity Relationship ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/genetics ; Substance-Related Disorders/metabolism
Czasopismo naukowe
Tytuł :
The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species.
Autorzy :
Borgan F; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
Beck K; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
Butler E; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
McCutcheon R; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.
Veronese M; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Vernon A; Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
Howes OD; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK. .; Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. .; Psychiatric Imaging Group, Faculty of Medicine, MRC London Institute of Medical Sciences (LMS), Imperial College London, London, UK. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2019 Nov; Vol. 236 (11), pp. 3257-3270. Date of Electronic Publication: 2019 Jun 05.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
Journal Info :
Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl.) Subsets: MEDLINE
MeSH Terms :
Cognition/*drug effects
Cognition/*physiology
Dronabinol/*pharmacology
Memory/*drug effects
Memory/*physiology
Receptor, Cannabinoid, CB1/*physiology
Animals ; Cannabinoids/adverse effects ; Cannabinoids/pharmacology ; Cognition Disorders/chemically induced ; Cognition Disorders/diagnosis ; Dronabinol/adverse effects ; Humans ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Species Specificity ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Probing the CB 1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist.
Autorzy :
Laprairie RB; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Vemuri K; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Stahl EL; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Korde A; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Ho JH; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Grim TW; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Hua T; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Wu Y; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Stevens RC; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Liu ZJ; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Makriyannis A; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.).
Bohn LM; Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida (R.B.L., E.L.S., J.-H.H., T.W.G., L.M.B.); Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (K.V., A.K., A.M.); iHuman Institute, ShanghaiTech University, Shanghai, China (T.H., Y.W., Z.-J.L.); and Departments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California (R.C.S.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2019 Nov; Vol. 96 (5), pp. 619-628. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Cannabinoid Receptor Antagonists/*metabolism
Cannabinoid Receptor Antagonists/*pharmacology
Nitrates/*metabolism
Nitrates/*pharmacology
Piperidines/*metabolism
Piperidines/*pharmacology
Pyrazoles/*metabolism
Pyrazoles/*pharmacology
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Receptor, Cannabinoid, CB1/*metabolism
Animals ; Binding Sites/drug effects ; Binding Sites/physiology ; CHO Cells ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Protein Binding/drug effects ; Protein Binding/physiology ; Protein Structure, Secondary ; Receptor, Cannabinoid, CB1/chemistry
Czasopismo naukowe
Tytuł :
Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.
Autorzy :
Garai S; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.
Kulkarni PM; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.
Schaffer PC; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.
Leo LM; Center for Substance Abuse Research, Lewis Katz School of Medicine , Temple University , Philadelphia , Pennsylvania 19140 , United States.
Brandt AL; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.
Zagzoog A; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.
Black T; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.
Lin X; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
Hurst DP; Center for Drug Discovery , University of North Carolina Greensboro , Greensboro , North Carolina 27402 , United States.
Janero DR; Department of Pharmaceutical Sciences, Bouvé College of Health Sciences, Department of Chemistry and Chemical Biology, College of Science, and Health Sciences Entrepreneurs , Northeastern University , Boston , Massachusetts 02115 , United States.
Abood ME; Center for Substance Abuse Research, Lewis Katz School of Medicine , Temple University , Philadelphia , Pennsylvania 19140 , United States.
Zimmowitch A; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
Straiker A; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
Pertwee RG; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences , University of Aberdeen , Aberdeen AB25 2ZD , Scotland, U.K.
Kelly M; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
Szczesniak AM; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
Denovan-Wright EM; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
Mackie K; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
Hohmann AG; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
Reggio PH; Center for Drug Discovery , University of North Carolina Greensboro , Greensboro , North Carolina 27402 , United States.
Laprairie RB; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
Thakur GA; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jan 23; Vol. 63 (2), pp. 542-568. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J. Med. Chem. Subsets: MEDLINE
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis
Fluorine/*chemistry
Indoles/*chemistry
Nitrogen/*chemistry
Receptor, Cannabinoid, CB1/*drug effects
Allosteric Regulation/drug effects ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Biotransformation ; Freund's Adjuvant ; HEK293 Cells ; Humans ; Indoles/pharmacokinetics ; Indoles/pharmacology ; Inflammation/chemically induced ; Inflammation/prevention & control ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Receptor, Cannabinoid, CB1/agonists ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation.
Autorzy :
Thapa D; Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Cairns EA; Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Szczesniak AM; Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Kulkarni PM; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Straiker AJ; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
Thakur GA; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Kelly MEM; Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2020 Jan 20.
Typ publikacji :
Journal Article
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
MeSH Terms :
Corneal Injuries/*drug therapy
Dronabinol/*analogs & derivatives
Hyperalgesia/*drug therapy
Indoles/*administration & dosage
Inflammation/*drug therapy
Receptor, Cannabinoid, CB1/*metabolism
Allosteric Regulation/drug effects ; Animals ; Cautery ; Corneal Injuries/complications ; Corneal Injuries/etiology ; Disease Models, Animal ; Dronabinol/administration & dosage ; Dronabinol/pharmacology ; Drug Synergism ; Gene Knockout Techniques ; Hyperalgesia/metabolism ; Indoles/pharmacology ; Inflammation/etiology ; Inflammation/metabolism ; Ligands ; Mice ; Receptor, Cannabinoid, CB1/chemistry ; Receptor, Cannabinoid, CB2/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Activation of Cannabinoid Receptors Attenuates Endothelin-1-Induced Mitochondrial Dysfunction in Rat Ventricular Myocytes.
Autorzy :
Lu Y; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.
Lee DI; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.
Roy Chowdhury S; Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.
Lu P; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Winnipeg Health Sciences Centre and Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Kamboj A; Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.
Anderson CM; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Winnipeg Health Sciences Centre and Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Fernyhough P; Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.; Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Anderson HD; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.; Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
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Źródło :
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2020 Jan; Vol. 75 (1), pp. 54-63.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Print Cited Medium: Internet ISSN: 1533-4023 (Electronic) Linking ISSN: 01602446 NLM ISO Abbreviation: J. Cardiovasc. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Cannabinoid Receptor Agonists/*pharmacology
Endothelin-1/*toxicity
Mitochondria, Heart/*drug effects
Myocytes, Cardiac/*drug effects
Naphthalenes/*pharmacology
Receptor, Cannabinoid, CB1/*agonists
Receptor, Cannabinoid, CB2/*agonists
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Animals, Newborn ; Cells, Cultured ; Energy Metabolism/drug effects ; Fatty Acids/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidation-Reduction ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
5F-MDMB-PICA metabolite identification and cannabinoid receptor activity.
Autorzy :
Truver MT; Department of Forensic Science, College of Criminal Justice, Sam Houston State University, Huntsville, TX, USA.
Watanabe S; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.
Åstrand A; Divison of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Vikingsson S; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.; Divison of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Green H; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.; Divison of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Swortwood MJ; Department of Forensic Science, College of Criminal Justice, Sam Houston State University, Huntsville, TX, USA.
Kronstrand R; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.; Divison of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
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Źródło :
Drug testing and analysis [Drug Test Anal] 2020 Jan; Vol. 12 (1), pp. 127-135. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article
Journal Info :
Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-7611 (Electronic) Linking ISSN: 19427603 NLM ISO Abbreviation: Drug Test Anal Subsets: MEDLINE
MeSH Terms :
Cannabinoids/*metabolism
Designer Drugs/*metabolism
Hepatocytes/*metabolism
Receptor, Cannabinoid, CB1/*agonists
Cannabinoids/pharmacology ; Cell Line ; Designer Drugs/pharmacology ; Halogenation ; Hepatocytes/drug effects ; Humans ; Hydrolysis ; Indazoles/metabolism ; Indazoles/pharmacology ; Male ; Middle Aged ; Oxidation-Reduction ; Psychotropic Drugs/metabolism ; Psychotropic Drugs/pharmacology ; Receptor, Cannabinoid, CB1/metabolism
Czasopismo naukowe
Tytuł :
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
Autorzy :
Shao Z; Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Yan W; Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Chapman K; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ramesh K; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ferrell AJ; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yin J; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wang X; Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Xu Q; GM/CA, Advanced Photon Source, Argonne National Laboratory, Argonne, IL, USA.
Rosenbaum DM; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2019 Dec; Vol. 15 (12), pp. 1199-1205. Date of Electronic Publication: 2019 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat. Chem. Biol. Subsets: MEDLINE
MeSH Terms :
Receptor, Cannabinoid, CB1/*metabolism
Allosteric Regulation ; Crystallization ; Cyclohexanols/pharmacology ; Humans ; Protein Binding ; Receptor, Cannabinoid, CB1/agonists
Czasopismo naukowe
Tytuł :
Inhibitory Control Deficits Associated with Upregulation of CB 1 R in the HIV-1 Tat Transgenic Mouse Model of Hand.
Autorzy :
Jacobs IR; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .
Xu C; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Hermes DJ; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
League AF; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Xu C; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Nath B; Department of Chemistry & Biochemistry, North Carolina Central University, Durham, NC, 27707, USA.
Jiang W; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 29425, USA.; Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Niphakis MJ; The Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Cravatt BF; The Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Mackie K; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
Mukhopadhyay S; Department of Chemistry & Biochemistry, North Carolina Central University, Durham, NC, 27707, USA.
Lichtman AH; Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Ignatowska-Jankowska BM; Neuronal Rhythms in Movement Unit, Okinawa Institute of Science and Technology, Okinawa, 904-0495, Japan.
Fitting S; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .
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Źródło :
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2019 Dec; Vol. 14 (4), pp. 661-678. Date of Electronic Publication: 2019 Aug 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE
MeSH Terms :
Disease Models, Animal*
HIV-1*
Inhibition, Psychological*
AIDS Dementia Complex/*metabolism
Receptor, Cannabinoid, CB1/*biosynthesis
tat Gene Products, Human Immunodeficiency Virus/*biosynthesis
AIDS Dementia Complex/genetics ; AIDS Dementia Complex/psychology ; Animals ; Female ; Limbic Lobe/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurocognitive Disorders/genetics ; Neurocognitive Disorders/metabolism ; Psychomotor Performance/physiology ; Receptor, Cannabinoid, CB1/genetics ; Up-Regulation/physiology ; tat Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
In vitro determination of the efficacy of illicit synthetic cannabinoids at CB 1 receptors.
Autorzy :
Sachdev S; Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
Vemuri K; Center for Drug Discovery, Department of Pharmaceutical Sciences and Chemical Biology, Northeastern University, Boston, Massachusetts.
Banister SD; The Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.; School of Chemistry, The University of Sydney, NSW, Australia.
Longworth M; School of Chemistry, The University of Sydney, NSW, Australia.
Kassiou M; School of Chemistry, The University of Sydney, NSW, Australia.
Santiago M; Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
Makriyannis A; Center for Drug Discovery, Department of Pharmaceutical Sciences and Chemical Biology, Northeastern University, Boston, Massachusetts.
Connor M; Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2019 Dec; Vol. 176 (24), pp. 4653-4665. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br. J. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Cannabinoid Receptor Agonists/*pharmacology
Cannabinoid Receptor Antagonists/*pharmacology
Cyclohexanols/*pharmacology
Illicit Drugs/*pharmacology
Receptor, Cannabinoid, CB1/*agonists
Animals ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Humans ; Mice ; Receptor, Cannabinoid, CB1/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.
Autorzy :
Nguyen T; Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Gamage TF; Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Decker AM; Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Barrus D; Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Langston TL; Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Li JX; Department of Pharmacology and Toxicology , University of Buffalo, the State University of New York , Buffalo , New York 14214 , United States.
Thomas BF; Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Zhang Y; Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2019 Nov 14; Vol. 62 (21), pp. 9806-9823. Date of Electronic Publication: 2019 Oct 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J. Med. Chem. Subsets: MEDLINE
MeSH Terms :
Phenylurea Compounds/*chemical synthesis
Phenylurea Compounds/*pharmacology
Receptor, Cannabinoid, CB1/*metabolism
Allosteric Regulation/drug effects ; Chemistry Techniques, Synthetic ; Cyclic AMP/metabolism ; HEK293 Cells ; Humans ; Phenylurea Compounds/chemistry ; Receptor, Cannabinoid, CB1/chemistry ; Structure-Activity Relationship
Czasopismo naukowe

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