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Wyszukujesz frazę ""Receptor, IGF Type 1"" wg kryterium: Temat

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Tytuł:
The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities.
Autorzy:
Werner H; Department of Human Molecular Genetics and Biochemistry, School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 04; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Phosphatidylinositol 3-Kinases*/metabolism
Receptor, IGF Type 1*/metabolism
Insulin-Like Growth Factor I/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IGF-1 Stimulates Glycolytic ATP Production in MCF-7L Cells.
Autorzy:
Rajoria B; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Zhang X; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Yee D; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 16; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin-Like Growth Factor I*/metabolism
Receptor, IGF Type 1*/metabolism
Tamoxifen/pharmacology ; Insulin ; Adenosine Triphosphate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circ_0005615 restrains the progression of multiple myeloma through modulating miR-331-3p and IGF1R regulatory cascade.
Autorzy:
Zhang Q; Department of Spinal Surgery, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Duan H; Center for Local Diseases and Chronic Diseases, Dongsheng District Center for Disease Control and Preventio, Ordos, 017000, Inner Mongolia, China.
Yang W; Department of Spinal Surgery, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Liu H; Department of Spinal Surgery, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Tao X; Department of Spinal Surgery, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Zhang Y; Department of Medical Imaging, Ordos Central Hospital, No. 23, Yijinhuoluoxi Street, Dongsheng District, Ordos, 017000, Inner Mongolia, China. .
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Źródło:
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2023 May 12; Vol. 18 (1), pp. 356. Date of Electronic Publication: 2023 May 12.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
Multiple Myeloma*/genetics
Receptor, IGF Type 1*/genetics
RNA, Circular*/genetics
Humans ; Apoptosis/genetics ; Blotting, Western ; Cell Count ; Cell Proliferation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells.
Autorzy:
Gaal OI; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Liu R; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Marginean D; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania.
Badii M; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Cabău G; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania.
Hotea I; Department of Rheumatology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Nica V; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania.
Colcear D; Clinical Infectious Disease Hospital, Cluj-Napoca, Romania.
Pamfil C; Department of Rheumatology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Merriman TR; Department of Microbiology, University of Otago, Dunedin, New Zealand.; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Rednic S; Department of Rheumatology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Popp RA; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania.
Crișan TO; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania. .; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. .
Joosten LAB; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur Nr.6, 400349, Cluj-Napoca, Romania.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
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Corporate Authors:
HINT Consortium
Źródło:
Scientific reports [Sci Rep] 2024 Feb 12; Vol. 14 (1), pp. 3565. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperuricemia*/complications
Gout*/genetics
Gout*/complications
Humans ; Uric Acid/metabolism ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/metabolism ; Leukocytes, Mononuclear/metabolism ; Genome-Wide Association Study ; Inflammation/metabolism ; Cytokines/metabolism ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insulin and IGF-1 have both overlapping and distinct effects on CD4 T cell mitochondria, metabolism, and function.
Autorzy:
Kiernan K; Department of Immunology, Duke University School of Medicine, Durham, NC, USA.
Alwarawrah Y; Department of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Nichols AG; Department of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Danzaki K; Department of Immunology, Duke University School of Medicine, Durham, NC, USA.
MacIver NJ; Department of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. nancie_.; Department of Nutrition, School of Medicine and Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. nancie_.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 21; Vol. 14 (1), pp. 4331. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin-Like Growth Factor I*/metabolism
Insulin*/metabolism
Receptor, IGF Type 1/metabolism ; Receptor, Insulin/metabolism ; Signal Transduction ; Mitochondria/metabolism ; CD4-Positive T-Lymphocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways.
Autorzy:
Cai W; Medical school, Anhui University of Science and Technology, 232001, Huainan, China.; Medical School, Anhui University of Science & Technology, Class 8, Grade 18, Clinical Major, 232001, Huainan, China.
Ma Y; Medical school, Anhui University of Science and Technology, 232001, Huainan, China.
Song L; Medical school, Anhui University of Science and Technology, 232001, Huainan, China.
Cao N; Medical school, Anhui University of Science and Technology, 232001, Huainan, China.
Gao J; Medical school, Anhui University of Science and Technology, 232001, Huainan, China.
Zhou S; Medical school, Anhui University of Science and Technology, 232001, Huainan, China.
Tang X; Medical school, Anhui University of Science and Technology, 232001, Huainan, China. .; Institute of Environment-friendly Materials and Occupational Health of Anhu University of Science and Technology (Wuhu), 241003, Wuhu, China. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Jan 25; Vol. 23 (1), pp. 87. Date of Electronic Publication: 2023 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/drug therapy
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Receptor, IGF Type 1*/metabolism
Humans ; Cell Line, Tumor ; Cell Proliferation ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Sorafenib/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The clinicopathological and prognostic significances of IGF-1R and Livin expression in patients with colorectal cancer.
Autorzy:
Zhang Z; Department of Gastroenterology, the Second Hospital of Dalian Medical University, Dalian, 116023, China.
Zhang Y; Department of Gastroenterology, the Second Hospital of Dalian Medical University, Dalian, 116023, China.
Lao S; Department of Gastroenterology, the Second Hospital of Dalian Medical University, Dalian, 116023, China.
Qiu J; Department of Gastroenterology, the Second Hospital of Dalian Medical University, Dalian, 116023, China.
Pan Z; Department of Pathology, the Second Hospital of Dalian Medical University, Dalian, 116023, China.
Feng X; Department of Gastroenterology, the Second Hospital of Dalian Medical University, Dalian, 116023, China. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Aug 05; Vol. 22 (1), pp. 855. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/pathology
Adaptor Proteins, Signal Transducing/*metabolism
Inhibitor of Apoptosis Proteins/*metabolism
Neoplasm Proteins/*metabolism
Receptor, IGF Type 1/*metabolism
Adaptor Proteins, Signal Transducing/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinogenesis/pathology ; Humans ; Immunohistochemistry ; Inhibitor of Apoptosis Proteins/analysis ; Neoplasm Proteins/analysis ; Neoplasm Staging ; Prognosis ; Receptor, IGF Type 1/analysis ; Receptor, IGF Type 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells.
Autorzy:
Zhu Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.; Traditional Chinese Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Chen S; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Liu W; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Xu F; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Lu J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Hayashi T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.; Department of Chemistry and Life Science, School of Advanced Engineering Kogakuin University, Tokyo, Japan.; Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan.
Mizuno K; Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan.
Hattori S; Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan.
Fujisaki H; Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan.
Ikejima T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2022 Sep; Vol. 63 (5), pp. 498-513. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin*/biosynthesis
Islets of Langerhans*/metabolism
Receptor, IGF Type 1*/metabolism
Signal Transduction*
YAP-Signaling Proteins*/metabolism
Animals ; Collagen Type V/pharmacology ; Phosphorylation ; RNA, Small Interfering/metabolism ; Rats ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway.
Autorzy:
Wu SM; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Tsai JJ; Division of Allergy, Immunology & Rheumatology, Department of Internal Medicine, Asia University Hospital, Taichung, Taiwan.
Pan HC; Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Ph.D. Program in Translational Medicine, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.
Arbiser JL; Department of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta Veterans Administration Health Center, Atlanta, Georgia, USA.
Elia L; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Lombardia, Italy.; Humanitas Clinical and Research Center, IRCCS, Rozzano, Lombardia, Italy.
Sheu ML; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Ph.D. Program in Translational Medicine, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Jul; Vol. 179 (13), pp. 3430-3451. Date of Electronic Publication: 2022 Feb 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Idiopathic Pulmonary Fibrosis*
Lung Injury*/metabolism
Receptor, IGF Type 1*/genetics
Receptor, IGF Type 1*/metabolism
Receptors, Aryl Hydrocarbon*/genetics
Receptors, Aryl Hydrocarbon*/metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors ; Bleomycin ; Humans ; Insulin-Like Growth Factor I/metabolism ; Lung ; Mice ; Mice, Knockout ; Transforming Growth Factor beta1/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance.
Autorzy:
Galal MA; Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.; Department of Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UK.
Alouch SS; Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Alsultan BS; Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Dahman H; Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Alyabis NA; Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Alammar SA; Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Aljada A; Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 09; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
Neoplasms*/genetics
Neoplasms*/metabolism
Somatomedins*
Humans ; Insulin/metabolism ; Receptor, Insulin/metabolism ; Drug Resistance, Neoplasm/genetics ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; Signal Transduction ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Insulin, Regular, Human ; Carcinogenesis/genetics ; Insulin-Like Growth Factor I/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insulin-Like Growth Factor-1 Receptor Targeted Fluorescent Imaging for Gallbladder Cancer in Orthotopic Mouse Models.
Autorzy:
Choi JH; Division of Gastroenterology, Department of Internal Medicine and Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Park JY; Division of Gastroenterology, Department of Internal Medicine and Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
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Źródło:
Gut and liver [Gut Liver] 2022 Jul 15; Vol. 16 (4), pp. 606-612. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji:
Journal Article
MeSH Terms:
Bile Duct Neoplasms*/diagnostic imaging
Gallbladder Neoplasms*/diagnostic imaging
Receptor, IGF Type 1*/metabolism
Animals ; Antibodies ; Cell Line, Tumor ; Disease Models, Animal ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR-6165/IGF1R axis.
Autorzy:
Shen D; Medical School, Southeast University, Nanjing, China.
Zhao H; Department of Clinical Research Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.
Zeng P; Medical School, Southeast University, Nanjing, China.
Ge M; Department of Clinical Research Center, Drum Tower Hospital of Nanjing, Nanjing, China.
Shrestha S; Medical School, Southeast University, Nanjing, China.
Zhao W; Medical School, Southeast University, Nanjing, China.
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2022 Jun; Vol. 1512 (1), pp. 46-60. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/genetics
Liver Neoplasms*/pathology
MicroRNAs*/genetics
RNA, Circular*/genetics
Receptor, IGF Type 1*/genetics
Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; In Situ Hybridization, Fluorescence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential expression of insulin-like growth factor type 1 receptor identifies heterogeneous intrahepatic regulatory T subsets in mouse hepatocellular carcinoma.
Autorzy:
Huang Y; Department of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Huang L; Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, PR China.
Zhu J; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Wu Y; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Shi J; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Dai K; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2022 May 13; Vol. 208 (1), pp. 47-59.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/metabolism
Receptor, IGF Type 1*/genetics
T-Lymphocytes, Regulatory*
Animals ; Disease Models, Animal ; Immune Tolerance ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer.
Autorzy:
Hsu XR; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu JE; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu YY; Clinical Medicine Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsiao SY; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Internal Medicine, Division of Hematology-Oncology, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
Liang JL; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Surgery, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Wu YJ; Department of Pathology, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
Tung CH; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Huang MF; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lin MS; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
Yang PC; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.; YongLin Institute of Health, National Taiwan University, Taipei, Taiwan.
Chen YL; Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .
Hong TM; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .; Clinical Medicine Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Oct 26; Vol. 42 (1), pp. 283. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Lung Neoplasms*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
Exosomes*/metabolism
Humans ; Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation/genetics ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Receptor, IGF Type 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis.
Autorzy:
Chakraborty S; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bhat AM; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mushtaq I; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Incyte Corporation, Wilmington, DE, USA.
Luan H; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Kalluchi A; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mirza S; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, UAE.
Storck MD; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Chaturvedi N; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Lopez-Guerrero JA; Laboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, Valencia, Spain.
Llombart-Bosch A; Department of Pathology, University of Valencia, Avd. Blasco Ibáñez 15, 46010, Valencia, Spain.
Machado I; Department of Pathology, University of Valencia, Avd. Blasco Ibáñez 15, 46010, Valencia, Spain.
Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Meza JL; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Ghosal G; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Coulter DW; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Jordan Rowley M; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Band V; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mohapatra BC; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .
Band H; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Department of Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Jul 20; Vol. 6 (1), pp. 758. Date of Electronic Publication: 2023 Jul 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms:
Sarcoma, Ewing*/genetics
Sarcoma, Ewing*/metabolism
Sarcoma, Ewing*/pathology
Mice ; Animals ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; Cell Membrane/metabolism ; Signal Transduction/physiology ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.
Autorzy:
Li S; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China. .
Liu F; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Zheng K; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Wang W; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Qiu E; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Pei Y; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Wang S; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Zhang J; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
Zhang X; Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, China.
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Źródło:
Molecular cancer [Mol Cancer] 2021 Dec 07; Vol. 20 (1), pp. 161. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Bone Neoplasms/*etiology
MicroRNAs/*genetics
Osteosarcoma/*etiology
RNA, Circular/*genetics
Receptor, IGF Type 1/*genetics
rac GTP-Binding Proteins/*genetics
Animals ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cisplatin/pharmacology ; Disease Models, Animal ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; Mice ; Osteosarcoma/drug therapy ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; RNA Interference ; Receptor, IGF Type 1/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options.
Autorzy:
Mancarella C; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Morrione A; Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
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Źródło:
Cells [Cells] 2021 Aug 13; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Receptor, IGF Type 1/*metabolism
Sarcoma/*pathology
Antibodies, Monoclonal/therapeutic use ; Hippo Signaling Pathway ; Humans ; Protein Kinase Inhibitors/therapeutic use ; Protein Serine-Threonine Kinases/metabolism ; Proteins/metabolism ; Receptor, IGF Type 1/antagonists & inhibitors ; Receptors, CXCR4/metabolism ; Receptors, Eph Family/metabolism ; Sarcoma/drug therapy ; Sarcoma/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis.
Autorzy:
Artico LL; Centro Infantil Boldrini, Campinas 13083-210, SP, Brazil.; Graduate Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, Campinas 13083-862, SP, Brazil.
Ruas JS; Centro Infantil Boldrini, Campinas 13083-210, SP, Brazil.
Teixeira Júnior JR; Centro Infantil Boldrini, Campinas 13083-210, SP, Brazil.; Graduate Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, Campinas 13083-862, SP, Brazil.
Migita NA; Centro Infantil Boldrini, Campinas 13083-210, SP, Brazil.
Seguchi G; Centro Infantil Boldrini, Campinas 13083-210, SP, Brazil.
Shi X; Department of Computer and Information Sciences, Temple University, Philadelphia, PA 19122, USA.
Brandalise SR; Centro Infantil Boldrini, Campinas 13083-210, SP, Brazil.
Castilho RF; Department of Pathology, School of Medical Sciences, University of Campinas, Campinas 13083-887, SP, Brazil.
Yunes JA; Centro Infantil Boldrini, Campinas 13083-210, SP, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*
Proto-Oncogene Proteins c-akt*/metabolism
Insulin-Like Growth Factor Binding Proteins*
Humans ; Cell Line, Tumor ; Cell Proliferation ; Glucose Transporter Type 1/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Receptor, IGF Type 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Asiatic acid in Centella asiatica extract towards morphological development in an intermittent hypoxia intrauterine embryo model and molecular prediction pathway of insulin-like growth factor-1 receptor signalling.
Autorzy:
Ariani A; Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.; Saiful Anwar General Hospital, Malang, Indonesia.
Ghofar IF; Esto Ebhu Hospital, Sumenep, Indonesia.
Khotimah H; Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Nurdiana N; Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Rahayu M; Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
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Źródło:
Open veterinary journal [Open Vet J] 2023 May; Vol. 13 (5), pp. 629-637. Date of Electronic Publication: 2023 May 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin-Like Growth Factor I*
Zebrafish*
Animals ; Female ; Humans ; Pregnancy ; Receptor, IGF Type 1 ; Molecular Docking Simulation ; Hypoxia/veterinary ; Plant Extracts
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor.
Autorzy:
Sheff J; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
Wang P; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada.
Xu P; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada.
Arbour M; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada.
Masson L; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada.
van Faassen H; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
Hussack G; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
Kemmerich K; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
Brunette E; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
Stanimirovic D; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
Hill JJ; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
Kelly J; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
Ni F; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2021 Feb 19; Vol. 11 (1), pp. 4284. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epitope Mapping*
Epitopes*/chemistry
Epitopes*/immunology
Blood-Brain Barrier/*metabolism
Receptor, IGF Type 1/*antagonists & inhibitors
Single-Domain Antibodies/*pharmacology
Amino Acid Sequence ; Antibody Affinity/immunology ; Humans ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Quantitative Structure-Activity Relationship ; Receptor, IGF Type 1/chemistry ; Receptor, IGF Type 1/immunology ; Receptor, IGF Type 1/metabolism ; Single-Domain Antibodies/chemistry ; Single-Domain Antibodies/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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