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Wyszukujesz frazę ""Receptor, Interferon alpha-beta"" wg kryterium: Temat


Tytuł :
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine.
Autorzy :
Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Michailidis E; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Chbihi M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Le Voyer T; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Rosain J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Philippot Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Seeleuthner Y; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.
Gervais A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Materna M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
de Oliveira PMN; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil.
Maia MLS; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil.
Dinis Ano Bom AP; Laboratory of Immunological Techniques, Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil.
Azamor T; Laboratory of Immunological Techniques, Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil.
Araújo da Conceição D; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil.
Goudouris E; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Homma A; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil.
Slesak G; Tropical Medicine Department, Tropenklinik Paul-Lechler-Krankenhaus, Tübingen, Germany.
Schäfer J; Tropical Medicine Department, Tropenklinik Paul-Lechler-Krankenhaus, Tübingen, Germany.
Pulendran B; Emory Vaccine Center and the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.; Institute for Immunity, Transplantation and Infection, Department of Pathology, Department of Microbiology and Immunology, Stanford University, Stanford, CA.
Miller JD; Emory Vaccine Center and the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.; Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Scientific Resources, Atlanta, GA.
Huits R; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Rosen LB; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Bizien L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Lorenzo L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Chrabieh M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.
Erazo LV; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.
Rozenberg F; Laboratory of Virology, University of Paris, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Jeljeli MM; Laboratory of Immunology, University of Paris, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Béziat V; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Holland SM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Su HC; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Ahmed R; Emory Vaccine Center and the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Seligman SJ; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; New York Medical College, Valhalla, NY.
Zhang Q; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Howard Hughes Medical Institute, New York, NY.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Apr 05; Vol. 218 (4).
Typ publikacji :
Journal Article
MeSH Terms :
Autoimmune Diseases*/genetics
Autoimmune Diseases*/immunology
COVID-19*/genetics
COVID-19*/immunology
Genetic Diseases, Inborn*/genetics
Genetic Diseases, Inborn*/immunology
Interferon-alpha*/genetics
Interferon-alpha*/immunology
Receptor, Interferon alpha-beta*/deficiency
Receptor, Interferon alpha-beta*/immunology
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
Yellow Fever Vaccine*/adverse effects
Yellow Fever Vaccine*/genetics
Yellow Fever Vaccine*/immunology
Yellow fever virus*/genetics
Yellow fever virus*/immunology
Antibodies, Neutralizing/*immunology
Autoantibodies/*immunology
Adolescent ; Adult ; Aged ; Female ; HEK293 Cells ; Humans ; Male ; Middle Aged ; Vaccines, Attenuated/genetics ; Vaccines, Attenuated/immunology
Czasopismo naukowe
Tytuł :
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway.
Autorzy :
Alicea-Torres K; The Wistar Institute, Philadelphia, PA, USA.
Sanseviero E; The Wistar Institute, Philadelphia, PA, USA.; AstraZeneca, Gaithersburg, MD, USA.
Gui J; Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania, Philadelphia, PA, USA.; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China.
Chen J; Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania, Philadelphia, PA, USA.
Veglia F; The Wistar Institute, Philadelphia, PA, USA.; H. Lee Moffitt Cancer Center, Tampa, FL, USA.
Yu Q; Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania, Philadelphia, PA, USA.
Donthireddy L; The Wistar Institute, Philadelphia, PA, USA.
Kossenkov A; The Wistar Institute, Philadelphia, PA, USA.
Lin C; The Wistar Institute, Philadelphia, PA, USA.
Fu S; The Wistar Institute, Philadelphia, PA, USA.
Mulligan C; Helen F. Graham Cancer Center and Research Institute, Newark, DE, USA.
Nam B; Helen F. Graham Cancer Center and Research Institute, Newark, DE, USA.
Masters G; Helen F. Graham Cancer Center and Research Institute, Newark, DE, USA.
Denstman F; Helen F. Graham Cancer Center and Research Institute, Newark, DE, USA.
Bennett J; Helen F. Graham Cancer Center and Research Institute, Newark, DE, USA.
Hockstein N; Helen F. Graham Cancer Center and Research Institute, Newark, DE, USA.
Rynda-Apple A; Department of Microbiology and Immunology, Montana State University, Bozeman, MT, USA.
Nefedova Y; The Wistar Institute, Philadelphia, PA, USA.
Fuchs SY; Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania, Philadelphia, PA, USA.
Gabrilovich DI; AstraZeneca, Gaithersburg, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1717. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Interferon Type I/*metabolism
Myeloid-Derived Suppressor Cells/*immunology
Neoplasms/*metabolism
Receptor, Interferon alpha-beta/*metabolism
Adult ; Aged ; Aged, 80 and over ; Animals ; Antineoplastic Agents/pharmacology ; Bone Marrow ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Monocytes/immunology ; Neutrophils/immunology ; Receptor, Interferon alpha-beta/genetics ; p38 Mitogen-Activated Protein Kinases/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge.
Autorzy :
Krolik M; Institute of Immunobiology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland.
Csepregi L; Institute of Immunobiology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland.
Hartmann F; Institute of Immunobiology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland.
Engetschwiler C; Institute of Immunobiology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland.
Flatz L; Institute of Immunobiology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland; Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland; Department of Oncology and Hematology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland; Department of Dermatology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland. Electronic address: .
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Źródło :
Vaccine [Vaccine] 2021 Feb 22; Vol. 39 (8), pp. 1257-1264. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocytic choriomeningitis virus*
Receptor, Interferon alpha-beta*/genetics
Viral Vaccines*
Animals ; CD8-Positive T-Lymphocytes ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Vaccines, Synthetic/genetics
Czasopismo naukowe
Tytuł :
Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads.
Autorzy :
Zanin N; NDORMS, The Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.
Viaris de Lesegno C; Institut Curie-Centre de Recherche, PSL Research University, Membrane Dynamics and Mechanics of Intracellular Signalling Laboratory, Paris, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.; Centre National de la Recherche Scientifique (CNRS), UMR 3666, Paris, France.
Lamaze C; Institut Curie-Centre de Recherche, PSL Research University, Membrane Dynamics and Mechanics of Intracellular Signalling Laboratory, Paris, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.; Centre National de la Recherche Scientifique (CNRS), UMR 3666, Paris, France.
Blouin CM; Institut Curie-Centre de Recherche, PSL Research University, Membrane Dynamics and Mechanics of Intracellular Signalling Laboratory, Paris, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.; Centre National de la Recherche Scientifique (CNRS), UMR 3666, Paris, France.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jan 20; Vol. 11, pp. 615603. Date of Electronic Publication: 2021 Jan 20 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Receptor, Interferon alpha-beta/*metabolism
Signal Transduction/*physiology
Animals ; Cell Membrane/metabolism ; Cytosol/metabolism ; Endocytosis ; Endosomal Sorting Complexes Required for Transport/metabolism ; Endosomes/metabolism ; Glycosylation ; Humans ; Interferons/metabolism ; Lysosomes/metabolism ; Membrane Proteins/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Domains ; Protein Processing, Post-Translational ; Protein Transport ; Protein-Tyrosine Kinases/metabolism ; Rats ; Receptor, Interferon alpha-beta/chemistry ; STAT Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Partial Protection From Lupus-Like Disease by B-Cell Specific Type I Interferon Receptor Deficiency.
Autorzy :
Keller EJ; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.; Cleveland Clinic Lerner College of Medicine, Dept. of Molecular Medicine, Case Western Reserve University, Cleveland, OH, United States.
Patel NB; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
Patt M; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
Nguyen JK; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, United States.
Jørgensen TN; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jan 08; Vol. 11, pp. 616064. Date of Electronic Publication: 2021 Jan 08 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
B-Lymphocytes/*immunology
Lupus Erythematosus, Systemic/*immunology
Receptor, Interferon alpha-beta/*immunology
Animals ; Germinal Center/immunology ; Interferon-alpha/immunology ; Interferon-beta/immunology ; Mice ; Mice, Knockout ; Receptor, Interferon alpha-beta/deficiency ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Early type I IFN blockade improves the efficacy of viral vaccines.
Autorzy :
Palacio N; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Dangi T; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Chung YR; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Wang Y; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Loredo-Varela JL; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Zhang Z; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Penaloza-MacMaster P; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 Dec 07; Vol. 217 (12).
Typ publikacji :
Journal Article
MeSH Terms :
Immunogenicity, Vaccine/*immunology
Interferon Type I/*antagonists & inhibitors
Interferon-alpha/*immunology
Receptor, Interferon alpha-beta/*immunology
Viral Vaccines/*immunology
Zika Virus/*immunology
Zika Virus Infection/*immunology
Animals ; Antibodies, Blocking/immunology ; Antibodies, Blocking/pharmacology ; Antibodies, Viral/immunology ; Antigen Presentation/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Dendritic Cells/immunology ; Disease Models, Animal ; Gene Expression/immunology ; HEK293 Cells ; Humans ; Immunologic Memory ; Interferon-alpha/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Receptor, Interferon alpha-beta/genetics ; Transfection ; Zika Virus Infection/virology
Czasopismo naukowe
Tytuł :
Structural integrity with functional plasticity: what type I IFN receptor polymorphisms reveal.
Autorzy :
de Weerd NA; Centre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, Victoria, Australia.
Vivian JP; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute and Australian Research Council Centre for Excellence for Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Lim SS; Centre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, Victoria, Australia.
Huang SU; Centre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, Victoria, Australia.
Hertzog PJ; Centre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, Victoria, Australia.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Sep; Vol. 108 (3), pp. 909-924.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Polymorphism, Single Nucleotide*
Receptor, Interferon alpha-beta/*genetics
Alternative Splicing ; Amino Acid Sequence ; Animals ; Codon, Nonsense/genetics ; Crystallography, X-Ray ; Disease Susceptibility ; Humans ; Immunity, Innate ; Immunogenicity, Vaccine ; Ligands ; Macrophages/immunology ; Mammals/genetics ; Mice ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Domains ; Receptor, Interferon alpha-beta/chemistry ; Receptor, Interferon alpha-beta/physiology ; Sequence Alignment ; Sequence Homology, Amino Acid ; Signal Transduction ; Structure-Activity Relationship ; Tuberculosis/immunology
Czasopismo naukowe
Tytuł :
Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis.
Autorzy :
Cho C; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mukherjee R; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Peck AR; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Sun Y; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
McBrearty N; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Katlinski KV; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Gui J; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Govindaraju PK; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Puré E; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Rui H; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Fuchs SY; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .
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Źródło :
Oncogene [Oncogene] 2020 Sep; Vol. 39 (38), pp. 6129-6137. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Tumor Microenvironment*/genetics
Cancer-Associated Fibroblasts/*metabolism
Neoplasms/*genetics
Neoplasms/*metabolism
Receptor, Interferon alpha-beta/*genetics
Animals ; Biomarkers, Tumor ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Immunohistochemistry ; Interferon Type I/metabolism ; Mice ; Neoplasms/pathology ; Receptor, Interferon alpha-beta/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Zika virus infection in chemosensory cells.
Autorzy :
Ozdener MH; Monell Chemical Senses Center, Philadelphia, PA, 19104, USA. .
Donadoni M; Department of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA.
Cicalese S; Department of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA.
Spielman AI; New York University College of Dentistry, New York, NY, 10010, USA.
Garcia-Blanco A; Monell Chemical Senses Center, Philadelphia, PA, 19104, USA.
Gordon J; Department of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA.
Sariyer IK; Department of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA. .
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Źródło :
Journal of neurovirology [J Neurovirol] 2020 Jun; Vol. 26 (3), pp. 371-381. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Chemoreceptor Cells/*virology
Receptor, Interferon alpha-beta/*immunology
Virus Replication/*physiology
Zika Virus/*pathogenicity
Zika Virus Infection/*virology
Animals ; Cell Line ; Chemoreceptor Cells/immunology ; Chemoreceptor Cells/pathology ; Female ; Gene Expression ; Host-Pathogen Interactions/immunology ; Humans ; Male ; Mice ; Mice, Knockout ; Organ Specificity ; Receptor, Interferon alpha-beta/deficiency ; Receptor, Interferon alpha-beta/genetics ; Smell/physiology ; Taste/physiology ; Zika Virus/growth & development ; Zika Virus/immunology ; Zika Virus Infection/immunology ; Zika Virus Infection/pathology
Czasopismo naukowe
Tytuł :
Cloning and characterisation of type I interferon receptor 1 in orange-spotted grouper (Epinephelus coioides) for response to nodavirus infection.
Autorzy :
Tang ZZ; Laboratory of Molecular Genetics, Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Agriculture Biotechnology Research Center, National Cheng Kung University, Tainan, 70101, Taiwan.
Wang TY; Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Agriculture Biotechnology Research Center, National Cheng Kung University, Tainan, 70101, Taiwan.
Chen YM; Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Agriculture Biotechnology Research Center, National Cheng Kung University, Tainan, 70101, Taiwan; University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Bachelor Degree Program in Marine Biotechnology, College of Life Sciences, National Taiwan Ocean University, Keelung, 20224, Taiwan; Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung, 20224, Taiwan.
Chen TY; Laboratory of Molecular Genetics, Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan; Agriculture Biotechnology Research Center, National Cheng Kung University, Tainan, 70101, Taiwan; University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan. Electronic address: .
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Źródło :
Fish & shellfish immunology [Fish Shellfish Immunol] 2020 Jun; Vol. 101, pp. 302-311. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Bass/*genetics
Bass/*immunology
Fish Diseases/*immunology
Gene Expression Regulation/*immunology
Immunity, Innate/*genetics
Receptor, Interferon alpha-beta/*genetics
Receptor, Interferon alpha-beta/*immunology
Amino Acid Sequence ; Animals ; Base Sequence ; Cytokines/metabolism ; Fish Diseases/virology ; Fish Proteins/chemistry ; Fish Proteins/genetics ; Fish Proteins/immunology ; Gene Expression Profiling/veterinary ; Lipopolysaccharides/administration & dosage ; Nodaviridae/physiology ; Phylogeny ; Poly I-C/administration & dosage ; RNA Virus Infections/immunology ; RNA Virus Infections/veterinary ; RNA Virus Infections/virology ; Receptor, Interferon alpha-beta/chemistry ; Sequence Alignment/veterinary
Czasopismo naukowe
Tytuł :
Loss of type I IFN responsiveness impairs natural killer cell antitumor activity in breast cancer.
Autorzy :
Zanker DJ; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Owen KL; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Baschuk N; Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia.
Spurling AJ; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Parker BS; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia. .; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia. .; Department of Biochemistry and Genetics, La Trobe Institute from Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Aug; Vol. 70 (8), pp. 2125-2138. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*immunology
Interferon Type I/*immunology
Killer Cells, Natural/*immunology
Animals ; Carcinogenesis/immunology ; Cell Line, Tumor ; Female ; Lymphocyte Activation/immunology ; Lymphocytes/immunology ; Mice ; Mice, Inbred C57BL ; Receptor, Interferon alpha-beta/immunology ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age.
Autorzy :
McGarry N; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Murray CL; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Garvey S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Wilkinson A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Tortorelli L; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Ryan L; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Hayden L; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Healy D; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Griffin EW; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Hennessy E; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Arumugam M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Skelly DT; Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.
Mitchell KJ; Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
Cunningham C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Jul; Vol. 95, pp. 413-428. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*
Cognitive Dysfunction*
Animals ; Humans ; Illness Behavior ; Immunity, Innate ; Mice ; Poly I-C ; RNA, Double-Stranded ; Receptor, Interferon alpha-beta/genetics ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.
Autorzy :
Ma Y; Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Huang Y; Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Zhao S; Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Key laboratory of big data for spinal deformities, Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Yao Y; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China.
Zhang Y; Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Qu J; Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Wu N; Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Key laboratory of big data for spinal deformities, Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Su J; Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2021 Jun 17; Vol. 30 (13), pp. 1247-1258.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes, Human, Pair 21*
COVID-19/*genetics
Interleukin-10 Receptor beta Subunit/*genetics
Receptor, Interferon alpha-beta/*genetics
Alleles ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; COVID-19/immunology ; Cytokines/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genomics/methods ; Humans ; Molecular Targeted Therapy ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci
Czasopismo naukowe
Tytuł :
Spondweni virus causes fetal harm in Ifnar1 mice and is transmitted by Aedes aegypti mosquitoes.
Autorzy :
Jaeger AS; Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, United States.
Weiler AM; Wisconsin National Primate Research Center, University of Wisconsin-Madison, United States.
Moriarty RV; Wisconsin National Primate Research Center, University of Wisconsin-Madison, United States.
Rybarczyk S; Wisconsin National Primate Research Center, University of Wisconsin-Madison, United States.
O'Connor SL; Wisconsin National Primate Research Center, University of Wisconsin-Madison, United States; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, United States.
O'Connor DH; Wisconsin National Primate Research Center, University of Wisconsin-Madison, United States; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, United States.
Seelig DM; Department of Veterinary Clinical Sciences, University of Minnesota, Twin Cities, United States.
Fritsch MK; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, United States.
Friedrich TC; Wisconsin National Primate Research Center, University of Wisconsin-Madison, United States; Department of Pathobiological Sciences, University of Wisconsin-Madison, United States.
Aliota MT; Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, United States. Electronic address: .
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Źródło :
Virology [Virology] 2020 Aug; Vol. 547, pp. 35-46. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aedes/*virology
Flavivirus/*physiology
Flavivirus Infections/*virology
Mosquito Vectors/*virology
Receptor, Interferon alpha-beta/*genetics
Aedes/physiology ; Animals ; Disease Models, Animal ; Female ; Flavivirus/genetics ; Flavivirus Infections/genetics ; Flavivirus Infections/metabolism ; Flavivirus Infections/mortality ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mosquito Vectors/physiology ; Receptor, Interferon alpha-beta/deficiency
Czasopismo naukowe
Tytuł :
Persistent Zika Virus Clinical Susceptibility despite Reduced Viral Burden in Mice with Expanded Virus-Specific CD8 T Cells Primed by Recombinant Listeria monocytogenes .
Autorzy :
Burg AR; Center for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, OH 45229.; Division of Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229; and.
Erickson JJ; Division of Neonatology, Cincinnati Children's Hospital, Cincinnati, OH 45229.
Turner LH; Center for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, OH 45229.; Division of Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229; and.
Pham G; Center for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, OH 45229.; Division of Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229; and.
Kinder JM; Center for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, OH 45229.; Division of Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229; and.
Way SS; Center for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, OH 45229; .; Division of Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229; and.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Jul 15; Vol. 205 (2), pp. 447-453. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Listeria monocytogenes/*physiology
Listeriosis/*immunology
Receptor, Interferon alpha-beta/*metabolism
Zika Virus/*physiology
Zika Virus Infection/*immunology
Animals ; Antibodies, Blocking/administration & dosage ; Cells, Cultured ; Disease Resistance ; Disease Susceptibility ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Peptides/immunology ; Receptor, Interferon alpha-beta/genetics ; Viral Envelope Proteins/immunology ; Viral Load
Czasopismo naukowe
Tytuł :
Type I interferon receptors and interferon-τ-stimulated genes in peripheral blood mononuclear cells and polymorphonuclear leucocytes during early pregnancy in beef heifers.
Autorzy :
Melo GD; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, Avenida Duque de Caxias Norte, 225, Campus Fernando Costa, University of São Paulo, 13635-900, Pirassununga, SP, Brazil.
Pinto LMF; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, Avenida Duque de Caxias Norte, 225, Campus Fernando Costa, University of São Paulo, 13635-900, Pirassununga, SP, Brazil.
Rocha CC; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, Avenida Duque de Caxias Norte, 225, Campus Fernando Costa, University of São Paulo, 13635-900, Pirassununga, SP, Brazil.
Motta IG; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, Avenida Duque de Caxias Norte, 225, Campus Fernando Costa, University of São Paulo, 13635-900, Pirassununga, SP, Brazil.
Silva LA; Department of Veterinary Medicine, School of Animal Science and Food Engineering, Avenida Duque de Caxias Norte, 225, Campus Fernando Costa, University of São Paulo, 13635-900, Pirassununga, SP, Brazil.
da Silveira JC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, Avenida Duque de Caxias Norte, 225, Campus Fernando Costa, University of São Paulo, 13635-900, Pirassununga, SP, Brazil.
Gonella-Diaza AM; North Florida Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Marianna, 4932 Highway 162, Marianna, FL 32446, USA.
Binelli M; Department of Animal Sciences, University of Florida, 2250 Shealy Drive, Gainesville, FL 32608, USA.
Pugliesi G; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, Avenida Duque de Caxias Norte, 225, Campus Fernando Costa, University of São Paulo, 13635-900, Pirassununga, SP, Brazil; and Corresponding author. Email: .
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Źródło :
Reproduction, fertility, and development [Reprod Fertil Dev] 2020 Jul; Vol. 32 (11), pp. 953-966.
Typ publikacji :
Journal Article
MeSH Terms :
2',5'-Oligoadenylate Synthetase/*metabolism
Leukocytes, Mononuclear/*metabolism
Myxovirus Resistance Proteins/*metabolism
Neutrophils/*metabolism
Receptor, Interferon alpha-beta/*metabolism
Ubiquitins/*metabolism
2',5'-Oligoadenylate Synthetase/genetics ; Animals ; Cattle ; Female ; Myxovirus Resistance Proteins/genetics ; Pregnancy ; Progesterone/blood ; Receptor, Interferon alpha-beta/genetics ; Ubiquitins/genetics
Czasopismo naukowe
Tytuł :
A high yielding IFNAR1 ECD mammalian expression process for use in autoimmune disease drug development.
Autorzy :
Kittinger C; Process Purification Sciences, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA. Electronic address: .
Barnes A; Antibody Discovery and Protein Engineering, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Hunter A; Process Purification Sciences, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Machiesky L; Analytical Sciences, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Phipps S; Antibody Discovery and Protein Engineering, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Shannon A; Analytical Sciences, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Stadelman R; Cell Culture and Fermentation Sciences, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Wilson S; Antibody Discovery and Protein Engineering, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
O'Connor E; Process Purification Sciences, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
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Źródło :
Protein expression and purification [Protein Expr Purif] 2020 Mar; Vol. 167, pp. 105528. Date of Electronic Publication: 2019 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Receptor, Interferon alpha-beta*/biosynthesis
Receptor, Interferon alpha-beta*/genetics
Receptor, Interferon alpha-beta*/isolation & purification
Autoimmune Diseases/*drug therapy
Animals ; Baculoviridae ; Batch Cell Culture Techniques ; Bioreactors ; CHO Cells ; Cloning, Molecular/methods ; Cricetulus ; Drug Development/methods ; HEK293 Cells ; Humans ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Autorzy :
Hayn M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Hirschenberger M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Koepke L; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Nchioua R; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Straub JH; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Klute S; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Hunszinger V; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Zech F; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Prelli Bozzo C; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Aftab W; Biomedical Center, Zentrallabor für Proteinanalytik (Protein Analysis Unit), Medical Faculty, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany; Graduate School for Quantitative Biosciences (QBM), Ludwig-Maximilians-University of Munich, 81377 Munich, Germany.
Christensen MH; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Conzelmann C; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Müller JA; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Srinivasachar Badarinarayan S; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, 72076 Tübingen, Germany.
Stürzel CM; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Forne I; Biomedical Center, Zentrallabor für Proteinanalytik (Protein Analysis Unit), Medical Faculty, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
Stenger S; Institute for Medical Microbiology and Hygiene, Ulm University Medical Center, 89081 Ulm, Germany.
Conzelmann KK; Max von Pettenkofer-Institute of Virology, Medical Faculty, and Gene Center, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
Münch J; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Schmidt FI; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Sauter D; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, 72076 Tübingen, Germany.
Imhof A; Biomedical Center, Zentrallabor für Proteinanalytik (Protein Analysis Unit), Medical Faculty, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2021 May 18; Vol. 35 (7), pp. 109126. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*virology
SARS-CoV-2/*immunology
Viral Proteins/*immunology
Animals ; Antiviral Agents/pharmacology ; Autophagosomes/immunology ; Autophagy/immunology ; COVID-19/immunology ; Cell Line ; Chlorocebus aethiops ; Exoribonucleases/immunology ; HEK293 Cells ; HeLa Cells ; Humans ; Immune Evasion ; Immunity, Innate ; Interferon Type I/metabolism ; Interferons/metabolism ; Receptor, Interferon alpha-beta/antagonists & inhibitors ; Receptor, Interferon alpha-beta/immunology ; SARS-CoV-2/pathogenicity ; Vero Cells ; Viral Nonstructural Proteins/immunology
Czasopismo naukowe
Tytuł :
Critical role of interferons in gastrointestinal injury repair.
Autorzy :
McElrath C; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; School of Graduate Studies, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Espinosa V; Pediatrics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Lin JD; School of Graduate Studies, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
Peng J; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; School of Graduate Studies, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Sridhar R; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; School of Graduate Studies, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Dutta O; School of Graduate Studies, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Pediatrics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Tseng HC; School of Graduate Studies, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Smirnov SV; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Risman H; Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Sandoval MJ; Department of Pathology, New York University School of Medicine, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
Davra V; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; School of Graduate Studies, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Chang YJ; Office of Advance Research Computing, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Pollack BP; Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.; Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
Birge RB; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Center for Cell Signaling, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Cancer Institute of New Jersey, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Galan M; Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Rivera A; Pediatrics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Durbin JE; Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.; Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Kotenko SV; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA. .; Center for Cell Signaling, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA. .; Cancer Institute of New Jersey, Rutgers-The State University of New Jersey, Newark, NJ, USA. .; Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2624. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Colitis, Ulcerative/*immunology
Interferons/*metabolism
Intestinal Mucosa/*pathology
Re-Epithelialization/*immunology
Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/pathology ; Dextran Sulfate/administration & dosage ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Epithelial Cells ; Female ; Humans ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Male ; Mice ; Mice, Knockout ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/metabolism ; Receptors, Interferon/genetics ; Receptors, Interferon/metabolism ; Signal Transduction/genetics ; Signal Transduction/immunology ; Specific Pathogen-Free Organisms
Czasopismo naukowe
Tytuł :
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Autorzy :
Gaziano L; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Giambartolomei C; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.; Genetics Department, Harvard Medical School, Harvard University, Boston, MA, USA.
Gaulton A; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Swanson SA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Iyengar SK; Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University and Louis Stoke, Cleveland VA, Cleveland, OH, USA.
Kosik NM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Vujkovic M; The Corporal Michael J. Crescenz VA Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Gagnon DR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Bento AP; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Barrio-Hernandez I; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Rönnblom L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Hagberg N; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Lundtoft C; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Langenberg C; Berlin Institute of Health, Charité University Medicine Berlin, Berlin, Germany.; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Pietzner M; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Valentine D; Institute of Health Informatics, University College London, London, UK.; Health Data Research, University College London, London, UK.
Gustincich S; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.
Tartaglia GG; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.
Allara E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Surendran P; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Burgess S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Zhao JH; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Peters JE; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College, London, UK.
Prins BP; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
Angelantonio ED; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
Devineni P; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Shi Y; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Lynch KE; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA.
DuVall SL; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA.
Garcon H; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Thomann LO; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Zhou JJ; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.; Phoenix VA Health Care System, Phoenix, AZ, USA.
Gorman BR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Huffman JE; Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
O'Donnell CJ; Cardiology, VA Boston Healthcare System, Boston, MA, USA.; Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Tsao PS; Epidemiology Research and Information Center (ERIC), VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Beckham JC; MIRECC, Durham VA Medical Center, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Pyarajan S; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Muralidhar S; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA.
Huang GD; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA.
Ramoni R; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA.
Beltrao P; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Danesh J; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
Hung AM; VA Tennessee Valley Healthcare System, Nashville, TN, USA.; Nephrology & Hypertension, Vanderbilt University, Nashville, TN, USA.
Chang KM; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Sun YV; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Joseph J; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Medicine, Cardiovascular, VA Boston Healthcare System and Brigham & Women's Hospital, Boston, MA, USA.
Leach AR; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Edwards TL; Department of Veterans Affairs, Tennessee Valley Healthcare System, Vanderbilt University, Nashville, TN, USA.; Medicine, Epidemiology, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Butterworth AS; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. .; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK. .; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. .; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. .; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. .
Casas JP; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. .; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. .
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Corporate Authors :
VA Million Veteran Program COVID-19 Science Initiative
Źródło :
Nature medicine [Nat Med] 2021 Apr; Vol. 27 (4), pp. 668-676. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Drug Repositioning*
SARS-CoV-2*
COVID-19/*genetics
Mendelian Randomization Analysis/*methods
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/physiology ; COVID-19/drug therapy ; Genome-Wide Association Study ; Humans ; Interleukin-10 Receptor beta Subunit/genetics ; Interleukin-10 Receptor beta Subunit/physiology ; Quantitative Trait Loci ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/physiology
Czasopismo naukowe

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