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Wyszukujesz frazę ""Receptor, Notch2"" wg kryterium: Temat


Tytuł :
MiR-18a-5p contributes to enhanced proliferation and migration of PASMCs via targeting Notch2 in pulmonary arterial hypertension.
Autorzy :
Miao R; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. Electronic address: .
Liu W; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Qi C; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Song Y; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. Electronic address: .
Zhang Y; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Fu Y; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Liu W; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Lang Y; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Zhang Y; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Zhang Z; Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 117919. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs/*genetics
Pulmonary Arterial Hypertension/*genetics
Receptor, Notch2/*metabolism
Animals ; Apoptosis/physiology ; Cell Hypoxia/physiology ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cells, Cultured ; China ; Familial Primary Pulmonary Hypertension/pathology ; Female ; Humans ; Hypertension, Pulmonary/metabolism ; Hypoxia/physiopathology ; Male ; MicroRNAs/metabolism ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Pulmonary Artery/metabolism ; Pulmonary Artery/pathology ; Rats ; Receptor, Notch2/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Notch - a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis.
Autorzy :
Jakovljevic A; Department of Pathophysiology, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Nikolic N; Department of Biology and Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Carkic J; Department of Biology and Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Andric M; Department of Oral Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Miletic M; Department of Pathophysiology, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Beljic-Ivanovic K; Department of Restorative Odontology and Endodontics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Jovanovic T; Department of Virusology, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Milasin J; Department of Biology and Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
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Źródło :
Acta odontologica Scandinavica [Acta Odontol Scand] 2020 Mar; Vol. 78 (2), pp. 126-131. Date of Electronic Publication: 2019 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Resorption*/virology
Epstein-Barr Virus Infections*
Jagged-1 Protein*/metabolism
Periapical Periodontitis*/metabolism
Periapical Periodontitis*/virology
Receptor, Notch2*/metabolism
Cytokines ; Herpesvirus 4, Human ; Humans ; Interleukin-1/metabolism ; Interleukin-6/metabolism ; Osteoprotegerin ; RANK Ligand/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Inflammation-induced colon cancer in uPA-deficient mice is associated with a deregulated expression of Notch signaling pathway components.
Autorzy :
Afaloniati H; Laboratory of Biochemistry and Toxicology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Karagiannis GS; Department of Anatomy & Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Karavanis E; Histology-Histopathology Laboratory, C' Army Veterinary Hospital, Camp Makri, Thessaloniki, Greece.
Psarra TA; Laboratory of Pharmacology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Karampatzakis-Kouritas A; Laboratory of Biochemistry and Toxicology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Poutahidis T; Laboratory of Pathology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Angelopoulou K; Laboratory of Biochemistry and Toxicology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Jan; Vol. 464 (1-2), pp. 181-191. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Signal Transduction*
Colonic Neoplasms/*metabolism
Neoplasm Proteins/*metabolism
Receptor, Notch1/*biosynthesis
Receptor, Notch2/*biosynthesis
Urokinase-Type Plasminogen Activator/*deficiency
Animals ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; Receptor, Notch1/genetics ; Receptor, Notch2/genetics
Czasopismo naukowe
Tytuł :
Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification.
Autorzy :
Gilbert MA; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Bauer RC; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Rajagopalan R; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Grochowski CM; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Chao G; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
McEldrew D; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Nassur JA; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Rand EB; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Krock BL; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kamath BM; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children and the University of Toronto, Toronto, Canada.
Krantz ID; Division of Human Genetics, Roberts Individualized Medical Genetics Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Piccoli DA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Loomes KM; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Spinner NB; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
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Źródło :
Human mutation [Hum Mutat] 2019 Dec; Vol. 40 (12), pp. 2197-2220. Date of Electronic Publication: 2019 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Loss of Function Mutation*
Mutation, Missense*
Alagille Syndrome/*genetics
Jagged-1 Protein/*genetics
Receptor, Notch2/*genetics
Alagille Syndrome/metabolism ; Female ; Genetic Predisposition to Disease ; Humans ; Jagged-1 Protein/metabolism ; Male ; Mutation Rate ; Pedigree ; Receptor, Notch2/metabolism
Czasopismo naukowe
Tytuł :
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity.
Autorzy :
Newell F; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. .
Wilmott JS; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Johansson PA; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nones K; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Addala V; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Mukhopadhyay P; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Broit N; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Amato CM; Center for Rare Melanomas, University of Colorado Cancer Center, Aurora, Colorado, USA.
Van Gulick R; Center for Rare Melanomas, University of Colorado Cancer Center, Aurora, Colorado, USA.
Kazakoff SH; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Patch AM; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Koufariotis LT; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Lakis V; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Leonard C; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Wood S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Holmes O; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Xu Q; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Lewis K; Center for Rare Melanomas, University of Colorado Cancer Center, Aurora, Colorado, USA.
Medina T; Center for Rare Melanomas, University of Colorado Cancer Center, Aurora, Colorado, USA.
Gonzalez R; Center for Rare Melanomas, University of Colorado Cancer Center, Aurora, Colorado, USA.
Saw RPM; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Spillane AJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal North Shore Hospital, Sydney, NSW, Australia.
Stretch JR; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Rawson RV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal Prince Alfred Hospital, Sydney, NSW, Australia.; New South Wales Health Pathology, Sydney, NSW, Australia.
Ferguson PM; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal Prince Alfred Hospital, Sydney, NSW, Australia.; New South Wales Health Pathology, Sydney, NSW, Australia.
Dodds TJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Thompson JF; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Long GV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal North Shore Hospital, Sydney, NSW, Australia.
Levesque MP; Dermatology Clinic, University Hospital Zürich, University of Zurich, Zurich, Switzerland.
Robinson WA; Center for Rare Melanomas, University of Colorado Cancer Center, Aurora, Colorado, USA.
Pearson JV; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Mann GJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; Centre for Cancer Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, NSW, Australia.
Scolyer RA; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.; Royal Prince Alfred Hospital, Sydney, NSW, Australia.; New South Wales Health Pathology, Sydney, NSW, Australia.
Waddell N; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Hayward NK; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
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Źródło :
Nature communications [Nat Commun] 2020 Oct 16; Vol. 11 (1), pp. 5259. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Melanoma/*genetics
Skin Neoplasms/*genetics
Female ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; Gene Amplification ; Gene Dosage ; Genomics ; Humans ; Male ; Melanoma/metabolism ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mutation ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Receptor, Notch2/genetics ; Receptor, Notch2/metabolism ; Skin Neoplasms/metabolism ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Down-regulation of circ_0061140 attenuates ectopic endometrial cell proliferation, migration and invasion in endometriosis via inactivating Notch2.
Autorzy :
Xu A; Department of Clinical Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jiang M; Department of Clinical Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li S; Department of Clinical Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Fei Q; Outpatient Department, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Oct 05; Vol. 757, pp. 144926. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Cell Proliferation*
Endometriosis/*genetics
RNA, Circular/*genetics
Cells, Cultured ; Down-Regulation ; Endometriosis/metabolism ; Endometriosis/pathology ; Endometrium/metabolism ; Endometrium/pathology ; Female ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/metabolism ; Receptor, Notch2/genetics ; Receptor, Notch2/metabolism
Czasopismo naukowe
Tytuł :
Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation.
Autorzy :
Boucher JM; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Ryzhova L; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Harrington A; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Davis-Knowlton J; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Turner JE; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Cooper E; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Maridas D; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Ryzhov S; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Rosen CJ; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Vary CPH; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
Liaw L; From the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Sep; Vol. 40 (9), pp. 2227-2243. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipogenesis*
Lipogenesis*
Adipocytes, White/*metabolism
Adipose Tissue, White/*metabolism
Obesity/*metabolism
Receptors, Notch/*metabolism
Adipocytes, White/pathology ; Adipose Tissue, White/pathology ; Adiposity ; Animals ; Ataxin-1/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Caloric Restriction ; Diet, High-Fat ; Disease Models, Animal ; Endoglin/metabolism ; Female ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Obesity/genetics ; Obesity/pathology ; Phenotype ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; Proteomics ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Receptor, Notch2/metabolism ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Receptors, Notch/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma.
Autorzy :
Zou Y; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, People's Republic of China.
Yang R; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, People's Republic of China.
Huang ML; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, People's Republic of China.
Kong YG; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, People's Republic of China.
Sheng JF; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, People's Republic of China.
Tao ZZ; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, People's Republic of China.
Gao L; Department of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, Jinan, China.
Chen SM; Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, People's Republic of China. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Nov 07; Vol. 38 (1), pp. 456. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Nasopharyngeal Carcinoma/*metabolism
Nasopharyngeal Carcinoma/*pathology
Proto-Oncogene Proteins c-akt/*metabolism
Receptor, Notch2/*metabolism
TNF Receptor-Associated Factor 6/*metabolism
Adult ; Aged ; Animals ; Biomarkers ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Mice ; Middle Aged ; Models, Molecular ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/mortality ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Protein Binding ; Receptor, Notch2/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α.
Autorzy :
Yu J; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030.; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.
Canalis E; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030 .; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.; Department of Medicine, UConn Health, Farmington, Connecticut 06030.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Sep 27; Vol. 294 (39), pp. 14203-14214. Date of Electronic Publication: 2019 Aug 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mutation*
Hajdu-Cheney Syndrome/*genetics
Osteoclasts/*metabolism
Receptor, Notch2/*genetics
Tumor Necrosis Factor-alpha/*metabolism
Animals ; Cells, Cultured ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Osteoclasts/drug effects ; Osteoclasts/pathology ; Receptor, Notch2/metabolism ; Transcription Factor HES-1/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro.
Autorzy :
González S; Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.
Uhm H; David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Deng SX; Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 Jul 17; Vol. 9 (1), pp. 10373. Date of Electronic Publication: 2019 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adult Stem Cells/*drug effects
Limbus Corneae/*cytology
Receptor, Notch1/*physiology
Receptor, Notch2/*physiology
Adult ; Adult Stem Cells/cytology ; Adult Stem Cells/metabolism ; Aged ; Basic Helix-Loop-Helix Transcription Factors/biosynthesis ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Cycle Proteins/biosynthesis ; Cell Cycle Proteins/genetics ; Cell Differentiation/drug effects ; Cells, Cultured ; Diamines/pharmacology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Middle Aged ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptor, Notch1/antagonists & inhibitors ; Receptor, Notch1/biosynthesis ; Receptor, Notch1/genetics ; Receptor, Notch2/antagonists & inhibitors ; Receptor, Notch2/biosynthesis ; Receptor, Notch2/genetics ; Thiazoles/pharmacology ; Transcription Factor HES-1/biosynthesis ; Transcription Factor HES-1/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors.
Autorzy :
Smith DC; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. .; University of Michigan Health System, 7302 Cancer Center, SPC 5946, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA. .
Chugh R; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Patnaik A; START, San Antonio, TX, USA.
Papadopoulos KP; START, San Antonio, TX, USA.
Wang M; OncoMed Pharmaceuticals, Inc., Redwood City, California, USA.
Kapoun AM; OncoMed Pharmaceuticals, Inc., Redwood City, California, USA.
Xu L; OncoMed Pharmaceuticals, Inc., Redwood City, California, USA.
Dupont J; OncoMed Pharmaceuticals, Inc., Redwood City, California, USA.
Stagg RJ; OncoMed Pharmaceuticals, Inc., Redwood City, California, USA.
Tolcher A; START, San Antonio, TX, USA.
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Źródło :
Investigational new drugs [Invest New Drugs] 2019 Aug; Vol. 37 (4), pp. 722-730. Date of Electronic Publication: 2018 Dec 28.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*administration & dosage
Antineoplastic Agents/*administration & dosage
Neoplasms/*drug therapy
Receptor, Notch2/*antagonists & inhibitors
Receptor, Notch3/*antagonists & inhibitors
Adult ; Aged ; Aged, 80 and over ; Anorexia/chemically induced ; Antibodies/blood ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacokinetics ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/immunology ; Antineoplastic Agents/pharmacokinetics ; Diarrhea/chemically induced ; Fatigue/chemically induced ; Female ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Nausea/chemically induced ; Neoplasms/genetics ; Neoplasms/metabolism ; Receptor, Notch2/genetics ; Receptor, Notch3/genetics ; Transcriptome ; Vomiting/chemically induced
Czasopismo naukowe
Tytuł :
Notch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry.
Autorzy :
Capulli M; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Hristova D; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Valbret Z; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Carys K; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Arjan R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Maurizi A; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Masedu F; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Cappariello A; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Rucci N; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy.
Teti A; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila Via Vetoio - Coppito 2, 67100, L'Aquila, Italy. .
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Źródło :
British journal of cancer [Br J Cancer] 2019 Jul; Vol. 121 (2), pp. 157-171. Date of Electronic Publication: 2019 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*secondary
Breast Neoplasms/*pathology
Hematopoietic Stem Cells/*physiology
Receptor, Notch2/*physiology
Animals ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Dibenzazepines/therapeutic use ; Drug Resistance, Neoplasm ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Osteoblasts/physiology ; Receptor, Notch2/antagonists & inhibitors ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism.
Autorzy :
Jastrzebski S; Department of Medicine, UConn Health, Farmington, CT 06030.
Kalinowski J; Department of Medicine, UConn Health, Farmington, CT 06030.
Mun S; Center on Aging, UConn Health, Farmington, CT 06030.
Shin B; Center on Aging, UConn Health, Farmington, CT 06030.
Adapala NS; Department of Orthopaedic Surgery, UConn Health, Farmington, CT 06030.
Jacome-Galarza CE; Department of Immunology, UConn Health, Farmington, CT 06030; and.
Mirza F; Department of Medicine, UConn Health, Farmington, CT 06030.
Aguila HL; Department of Immunology, UConn Health, Farmington, CT 06030; and.
Drissi H; Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30329.
Sanjay A; Department of Orthopaedic Surgery, UConn Health, Farmington, CT 06030.
Canalis E; Department of Medicine, UConn Health, Farmington, CT 06030.; Department of Orthopaedic Surgery, UConn Health, Farmington, CT 06030.
Lee SK; Center on Aging, UConn Health, Farmington, CT 06030.
Lorenzo JA; Department of Medicine, UConn Health, Farmington, CT 06030; .; Department of Orthopaedic Surgery, UConn Health, Farmington, CT 06030.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Jul 01; Vol. 203 (1), pp. 105-116. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Bone Diseases/*immunology
Inflammation/*immunology
Osteoclasts/*physiology
Receptor, Notch2/*metabolism
Receptor, PAR-1/*metabolism
Animals ; Antibodies, Neutralizing/metabolism ; Cells, Cultured ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Osteogenesis/genetics ; RANK Ligand/metabolism ; Receptor, Notch2/immunology ; Receptor, PAR-1/genetics ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
MiR-431 is a prognostic marker and suppresses cell growth, migration and invasion by targeting NOTCH2 in melanoma.
Autorzy :
Sun YW; Department of Oncology, Intravenous Drug Control Room; People's Hospital of Rizhao, Rizhao, Shandong, China. .
Li XH
Wang H
Wu J
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Źródło :
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2019 May; Vol. 23 (9), pp. 3876-3884.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Melanoma/*pathology
MicroRNAs/*metabolism
Receptor, Notch2/*metabolism
Skin Neoplasms/*pathology
3' Untranslated Regions ; Antagomirs/metabolism ; Apoptosis ; Binding Sites ; Cell Line, Tumor ; Cell Movement ; Female ; Humans ; Male ; Melanoma/genetics ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Middle Aged ; Prognosis ; Receptor, Notch2/chemistry ; Receptor, Notch2/genetics ; Skin Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Autorzy :
Colom B; Wellcome Sanger Institute, Hinxton, UK.
Alcolea MP; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Piedrafita G; Wellcome Sanger Institute, Hinxton, UK.; Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Hall MWJ; Wellcome Sanger Institute, Hinxton, UK.; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Wabik A; Wellcome Sanger Institute, Hinxton, UK.
Dentro SC; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.
Fowler JC; Wellcome Sanger Institute, Hinxton, UK.
Herms A; Wellcome Sanger Institute, Hinxton, UK.
King C; Wellcome Sanger Institute, Hinxton, UK.
Ong SH; Wellcome Sanger Institute, Hinxton, UK.
Sood RK; Wellcome Sanger Institute, Hinxton, UK.
Gerstung M; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.
Martincorena I; Wellcome Sanger Institute, Hinxton, UK.
Hall BA; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK. .
Jones PH; Wellcome Sanger Institute, Hinxton, UK. .; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK. .
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Źródło :
Nature genetics [Nat Genet] 2020 Jun; Vol. 52 (6), pp. 604-614. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Esophagus/*cytology
ADAM10 Protein/genetics ; Amyloid Precursor Protein Secretases/genetics ; Animals ; Cell Lineage ; Diethylnitrosamine/toxicity ; Epithelium/drug effects ; Epithelium/pathology ; Epithelium/physiology ; Esophagus/physiology ; Female ; High-Throughput Nucleotide Sequencing ; Male ; Membrane Proteins/genetics ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptor, Notch1/genetics ; Receptor, Notch2/genetics ; Reproducibility of Results ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Nr5a1 suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling.
Autorzy :
Nomura R; Department of Pediatrics and Developmental Biology, Tokyo Medical Dental University, Tokyo 113-8510, Japan.
Kashimada K; Department of Pediatrics and Developmental Biology, Tokyo Medical Dental University, Tokyo 113-8510, Japan .
Suzuki H; Department of Experimental Animal Model for Human Disease, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Zhao L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Tsuji-Hosokawa A; Department of Pediatrics and Developmental Biology, Tokyo Medical Dental University, Tokyo 113-8510, Japan.
Yagita H; Department of Immunology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Takagi M; Department of Pediatrics and Developmental Biology, Tokyo Medical Dental University, Tokyo 113-8510, Japan.
Kanai Y; Department of Veterinary Anatomy, The University of Tokyo, Tokyo 113-8657, Japan.
Bowles J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Koopman P; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Kanai-Azuma M; Department of Experimental Animal Model for Human Disease, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Morio T; Department of Pediatrics and Developmental Biology, Tokyo Medical Dental University, Tokyo 113-8510, Japan.
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Źródło :
Journal of cell science [J Cell Sci] 2019 Apr 15; Vol. 132 (8). Date of Electronic Publication: 2019 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sexual Development*
Ovary/*physiology
Receptor, Notch2/*physiology
Steroidogenic Factor 1/*physiology
Testis/*physiology
Animals ; Cell Differentiation ; Female ; Gene Expression Regulation, Developmental ; Male ; Mice ; Mice, Transgenic ; Phenotype ; Receptor, Notch2/genetics ; Signal Transduction ; Steroidogenic Factor 1/genetics
Czasopismo naukowe
Tytuł :
Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.
Autorzy :
Tomé M; Department of Biomedicine, Pharmazentrum, University of Basel, 4056 Basel, Switzerland. Electronic address: .
Tchorz J; Department of Biomedicine, Pharmazentrum, University of Basel, 4056 Basel, Switzerland.
Gassmann M; Department of Biomedicine, Pharmazentrum, University of Basel, 4056 Basel, Switzerland.
Bettler B; Department of Biomedicine, Pharmazentrum, University of Basel, 4056 Basel, Switzerland. Electronic address: .
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Źródło :
Stem cell research [Stem Cell Res] 2019 Mar; Vol. 35, pp. 101390. Date of Electronic Publication: 2019 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*metabolism
Drug Resistance, Neoplasm/*drug effects
Etoposide/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Glioblastoma/*metabolism
Neural Stem Cells/*metabolism
Receptor, Fibroblast Growth Factor, Type 1/*biosynthesis
Receptor, Notch2/*metabolism
Signal Transduction/*drug effects
Transcriptional Activation/*drug effects
Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Mice, Transgenic ; Neural Stem Cells/pathology ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Notch2/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization.
Autorzy :
Lin X; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.
Wang S; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.
Sun M; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.
Zhang C; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.
Wei C; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.
Yang C; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.
Dou R; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.
Liu Q; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China.
Xiong B; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China. .; Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China. .; Hubei Key Laboratory of Tumor Biological Behaviors, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China. .; Hubei Cancer Clinical Study Center, No.169 Donghu Road, Wuchang District, Wuhan, 430071, China. .
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Źródło :
Journal of hematology & oncology [J Hematol Oncol] 2019 Feb 26; Vol. 12 (1), pp. 20. Date of Electronic Publication: 2019 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*metabolism
Interleukin-4/*metabolism
Macrophages/*metabolism
MicroRNAs/*metabolism
Receptor, Notch2/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition ; Female ; HCT116 Cells ; Heterografts ; Humans ; Macrophages/pathology ; Mice ; Mice, Nude ; MicroRNAs/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptor, Notch2/biosynthesis ; Receptor, Notch2/genetics ; Transfection ; Tumor Microenvironment ; Up-Regulation
Czasopismo naukowe
Tytuł :
Functional evidence implicating NOTCH2 missense mutations in primary ovarian insufficiency etiology.
Autorzy :
Patiño LC; Center For Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Beau I; Inserm U1185, Faculté de Médecine Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Morel A; Center For Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Delemer B; Service d'Endocrinologie-Diabète-Nutrition, CHU de Reims-Hôpital Robert-Debré, Reims, France.
Young J; Inserm U1185, Faculté de Médecine Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, Department of Reproductive Endocrinology, Université Paris Sud, Le Kremlin-Bicêtre, France.
Binart N; Inserm U1185, Faculté de Médecine Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Laissue P; Center For Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
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Źródło :
Human mutation [Hum Mutat] 2019 Jan; Vol. 40 (1), pp. 25-30. Date of Electronic Publication: 2018 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Mutation, Missense/*genetics
Primary Ovarian Insufficiency/*genetics
Receptor, Notch2/*genetics
Amino Acid Sequence ; Female ; Humans ; Receptor, Notch2/chemistry ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Long non-coding RNA ARAP1-AS1 promotes the progression of bladder cancer by regulating miR-4735-3p/NOTCH2 axis.
Autorzy :
Teng J; a Department of Urology , PLA Army General Hospital , Beijing China.
Ai X; a Department of Urology , PLA Army General Hospital , Beijing China.
Jia Z; a Department of Urology , PLA Army General Hospital , Beijing China.
Wang K; b Department of Urology , Zhejiang Xiaoshan Hospital , Hangzhou , Zhejiang province , China.
Guan Y; a Department of Urology , PLA Army General Hospital , Beijing China.
Guo Y; a Department of Urology , PLA Army General Hospital , Beijing China.
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Źródło :
Cancer biology & therapy 2019; Vol. 20 (4), pp. 552-561. Date of Electronic Publication: 2018 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carrier Proteins/*antagonists & inhibitors
GTPase-Activating Proteins/*antagonists & inhibitors
MicroRNAs/*genetics
RNA, Antisense/*genetics
RNA, Long Noncoding/*genetics
Receptor, Notch2/*metabolism
Urinary Bladder Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Movement ; Cell Proliferation ; Disease Progression ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Receptor, Notch2/genetics ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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