Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Receptor, trkB"" wg kryterium: Temat


Tytuł :
LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer's disease.
Autorzy :
Fan CH; Department of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan.
Lin CW; Department of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan.
Huang HJ; Department of Nursing, Mackay Junior College of Medicine, Nursing and Management, Taipei, 11260, Taiwan.
Lee-Chen GJ; Department of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan.
Sun YC; Department of Chemistry, National Taiwan Normal University, Taipei, 11677, Taiwan.
Lin W; Department of Chemistry, National Taiwan Normal University, Taipei, 11677, Taiwan.
Chen CM; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, 33305, Taiwan.
Chang KH; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, 33305, Taiwan.
Su MT; Department of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan. .
Hsieh-Li HM; Department of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan. .
Pokaż więcej
Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Oct; Vol. 237 (10), pp. 3173-3190. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*chemically induced
Alzheimer Disease/*prevention & control
Amyloid beta-Peptides/*toxicity
Nerve Growth Factors/*therapeutic use
Neuroprotective Agents/*therapeutic use
Peptide Fragments/*toxicity
Receptor, trkB/*agonists
Alzheimer Disease/metabolism ; Animals ; Cells, Cultured ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Growth Factors/pharmacology ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/physiology ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotective Agents/pharmacology ; Random Allocation ; Receptor, trkB/metabolism
Czasopismo naukowe
Tytuł :
STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.
Autorzy :
Paris AJ; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hayer KE; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Oved JH; Division of Hematology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Avgousti DC; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Toulmin SA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zepp JA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zacharias WJ; Division of Pulmonary Biology, Perinatal Institute, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Katzen JB; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Basil MC; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kremp MM; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Slamowitz AR; Department of Pediatrics, Children's National, Washington, DC, USA.
Jayachandran S; Division of Cardiology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sivakumar A; Division of Cardiology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dai N; Division of Neonatology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wang P; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Frank DB; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Cardiology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eisenlohr LC; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Cantu E 3rd; Division of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Beers MF; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Weitzman MD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Morrisey EE; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for Regenerative Medicine, Perelman School of Medicine, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Worthen GS; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .; Division of Neonatology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
Pokaż więcej
Źródło :
Nature cell biology [Nat Cell Biol] 2020 Oct; Vol. 22 (10), pp. 1197-1210. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Regeneration*
Alveolar Epithelial Cells/*cytology
Brain-Derived Neurotrophic Factor/*metabolism
Lung Injury/*prevention & control
Membrane Glycoproteins/*metabolism
Protein-Tyrosine Kinases/*metabolism
Receptor, trkB/*metabolism
STAT3 Transcription Factor/*metabolism
Alveolar Epithelial Cells/metabolism ; Animals ; Brain-Derived Neurotrophic Factor/genetics ; Female ; Humans ; Lung Injury/etiology ; Lung Injury/pathology ; Male ; Membrane Glycoproteins/genetics ; Protein-Tyrosine Kinases/genetics ; Receptor, trkB/genetics ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors.
Autorzy :
Vukojevic V; Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland; .; Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland.; University Psychiatric Clinics, University of Basel, CH-4055 Basel, Switzerland.; Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland.
Coynel D; Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland.; Department of Psychology, Division of Cognitive Neuroscience, University of Basel, 4055 Basel, Switzerland.
Ghaffari NR; Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland.; Department of Psychology, Division of Cognitive Neuroscience, University of Basel, 4055 Basel, Switzerland.; Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800.
Freytag V; Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland.; Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland.; University Psychiatric Clinics, University of Basel, CH-4055 Basel, Switzerland.
Elbert T; Clinical Psychology, University of Konstanz, D-78457 Konstanz, Germany.
Kolassa IT; Clinical & Biological Psychology, Institute for Psychology & Education, Ulm University, D-89069 Ulm, Germany.
Wilker S; Department for Psychology and Sports Science, University Bielefeld, D-33501 Bielefeld, Germany.
McGaugh JL; Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800; .
Papassotiropoulos A; Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland.; Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland.; University Psychiatric Clinics, University of Basel, CH-4055 Basel, Switzerland.; Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland.
de Quervain DJ; Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland; .; University Psychiatric Clinics, University of Basel, CH-4055 Basel, Switzerland.; Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland.; Department of Psychology, Division of Cognitive Neuroscience, University of Basel, 4055 Basel, Switzerland.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 01; Vol. 117 (35), pp. 21667-21672. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Membrane Glycoproteins/*genetics
Receptor, trkB/*genetics
Stress Disorders, Post-Traumatic/*genetics
Adult ; Aged ; Brain/metabolism ; DNA Methylation/genetics ; Epigenesis, Genetic/genetics ; Female ; Glucocorticoids/metabolism ; Humans ; Male ; Membrane Glycoproteins/metabolism ; Memory/physiology ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Receptor, trkB/metabolism ; Receptors, Glucocorticoid/metabolism ; Risk Factors ; Rwanda/epidemiology ; Stress Disorders, Post-Traumatic/metabolism ; Survivors ; Uganda/epidemiology
Czasopismo naukowe
Tytuł :
Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms.
Autorzy :
Joshi SK; Knight Cancer Institute.; Department of Physiology and Pharmacology, School of Medicine, and.; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR.
Qian K; Knight Cancer Institute.
Bisson WH; Knight Cancer Institute.; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR; and.
Watanabe-Smith K; Knight Cancer Institute.
Huang A; Knight Cancer Institute.
Bottomly D; Knight Cancer Institute.
Traer E; Knight Cancer Institute.; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR.; Department of Cell, Development, and Cancer Biology.
Tyner JW; Knight Cancer Institute.; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR.; Department of Cell, Development, and Cancer Biology.
McWeeney SK; Knight Cancer Institute.; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology.
Davare MA; Department of Cell, Development, and Cancer Biology.; Papé Pediatric Research Institute.; Division of Pediatric Hematology and Oncology, Department of Pediatrics, and.
Druker BJ; Knight Cancer Institute.; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR.; Department of Cell, Development, and Cancer Biology.; Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR.
Tognon CE; Knight Cancer Institute.; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR.; Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR.
Pokaż więcej
Źródło :
Blood [Blood] 2020 Jun 11; Vol. 135 (24), pp. 2159-2170.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Point Mutation*
Hematologic Neoplasms/*genetics
Membrane Glycoproteins/*genetics
Receptor, trkB/*genetics
Receptor, trkC/*genetics
Animals ; Base Sequence ; Benzamides/therapeutic use ; Cell Line ; Drug Resistance, Neoplasm/genetics ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/metabolism ; Humans ; Indazoles/therapeutic use ; Lipid Metabolism ; Membrane Glycoproteins/chemistry ; Membrane Glycoproteins/metabolism ; Mice ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Oncogenes ; Protein Kinase Inhibitors/therapeutic use ; Protein Multimerization/genetics ; RNA, Small Interfering/genetics ; Receptor, trkB/chemistry ; Receptor, trkB/metabolism ; Receptor, trkC/chemistry ; Receptor, trkC/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Expression and Localization of BDNF/TrkB System in the Zebrafish Inner Ear.
Autorzy :
Germanà A; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Guerrera MC; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Laurà R; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Levanti M; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Aragona M; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Mhalhel K; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Germanà G; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Montalbano G; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Abbate F; Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 12; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Brain-Derived Neurotrophic Factor/*metabolism
Ear, Inner/*metabolism
Receptor, trkB/*metabolism
Zebrafish/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Brain-Derived Neurotrophic Factor/genetics ; Ear, Inner/anatomy & histology ; Ear, Inner/ultrastructure ; Gene Expression Regulation, Developmental ; Larva/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, trkB/genetics ; Zebrafish/genetics ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.
Autorzy :
Pattwell SS; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.
Arora S; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.
Cimino PJ; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.; Department of Pathology, University of Washington School of Medicine, 325 9th Avenue, Box 359791, Seattle, WA, 98104, USA.
Ozawa T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Szulzewsky F; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.
Hoellerbauer P; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.; Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195, USA.
Bonifert T; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.
Hoffstrom BG; Antibody Technology Resource, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, 98109, USA.
Boiani NE; Antibody Technology Resource, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, 98109, USA.
Bolouri H; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.; Systems Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA, 98101, USA.
Correnti CE; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, 98109, USA.
Oldrini B; Seve Ballesteros Foundation Brain Tumor Group, Spanish National Cancer Research Centre, 28209, Madrid, Spain.
Silber JR; Department of Neurological Surgery, Alvord Brain Tumor Center, University of Washington School of Medicine, Seattle, WA, 98104, USA.
Squatrito M; Seve Ballesteros Foundation Brain Tumor Group, Spanish National Cancer Research Centre, 28209, Madrid, Spain.
Paddison PJ; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.; Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195, USA.
Holland EC; Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA. .; Department of Neurological Surgery, Alvord Brain Tumor Center, University of Washington School of Medicine, Seattle, WA, 98104, USA. .; Seattle Tumor Translational Research Center, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, 98109, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Jun 12; Vol. 11 (1), pp. 2977. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
Brain Neoplasms/*genetics
Glioma/*genetics
Membrane Glycoproteins/*genetics
Oncogenes/*genetics
RNA Isoforms/*genetics
Receptor, trkB/*genetics
Animals ; Brain/metabolism ; Brain/pathology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Carcinogenesis/genetics ; Cells, Cultured ; Gene Expression Profiling ; Gene Ontology ; Glioma/metabolism ; Glioma/pathology ; High-Throughput Nucleotide Sequencing ; Humans ; Membrane Glycoproteins/metabolism ; Mice ; NIH 3T3 Cells ; Neural Stem Cells/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; RNA Isoforms/metabolism ; Receptor, trkB/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Electroacupuncture ameliorates post-traumatic stress disorder in rats via a mechanism involving the BDNF-TrkB signaling pathway.
Autorzy :
Li M; Chinese medicine College, Hainan Medical University, No.3, Xueyuan Road, Longhua District, Haikou City, Hainan Province, China.
Xie Y; Chinese medicine College, Hainan Medical University, No.3, Xueyuan Road, Longhua District, Haikou City, Hainan Province, China.
Niu K; Chinese medicine College, Hainan Medical University, No.3, Xueyuan Road, Longhua District, Haikou City, Hainan Province, China.
Li K; Chinese medicine College, Hainan Medical University, No.3, Xueyuan Road, Longhua District, Haikou City, Hainan Province, China.
Pokaż więcej
Źródło :
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2020 Jun 05; Vol. 66 (3), pp. 165-170. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Electroacupuncture*
Signal Transduction*
Brain-Derived Neurotrophic Factor/*metabolism
Receptor, trkB/*metabolism
Stress Disorders, Post-Traumatic/*metabolism
Stress Disorders, Post-Traumatic/*therapy
Animals ; Brain-Derived Neurotrophic Factor/genetics ; Conditioning, Classical ; Cues ; Extinction, Psychological ; Fear ; Male ; Motor Activity ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Receptor, trkB/genetics ; Stress Disorders, Post-Traumatic/genetics ; Stress Disorders, Post-Traumatic/physiopathology
Czasopismo naukowe
Tytuł :
Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.
Autorzy :
Fang X; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Yang C; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Li S; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Zhan G; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Zhang J; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Huang N; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Du X; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Xu H; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Hashimoto K; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. .
Luo A; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China. .
Pokaż więcej
Źródło :
European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2020 Mar; Vol. 270 (2), pp. 195-205. Date of Electronic Publication: 2018 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Anhedonia/*physiology
Behavior, Animal/*physiology
Brain-Derived Neurotrophic Factor/*metabolism
Neuralgia/*metabolism
Neuralgia/*physiopathology
Prefrontal Cortex/*metabolism
Receptor, trkB/*metabolism
Signal Transduction/*physiology
Anhedonia/drug effects ; Animals ; Behavior, Animal/drug effects ; Disease Models, Animal ; Male ; Neuralgia/etiology ; Nucleus Accumbens/metabolism ; Peripheral Nerve Injuries/complications ; Peripheral Nerve Injuries/physiopathology ; Phenotype ; Rats ; Rats, Sprague-Dawley ; Receptor, trkB/agonists ; Receptor, trkB/antagonists & inhibitors ; Signal Transduction/drug effects ; Sucrose
Czasopismo naukowe
Tytuł :
Parkinson's Disease-Associated Changes in the Expression of Neurotrophic Factors and their Receptors upon Neuronal Differentiation of Human Induced Pluripotent Stem Cells.
Autorzy :
Novosadova EV; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Nenasheva VV; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia. .
Makarova IV; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Dolotov OV; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Inozemtseva LS; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Arsenyeva EL; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Chernyshenko SV; Moscow State Region University, Moscow, Russia.
Sultanov RI; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Illarioshkin SN; Research Center of Neurology, Moscow, Russia.
Grivennikov IA; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Tarantul VZ; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Pokaż więcej
Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2020 Apr; Vol. 70 (4), pp. 514-521. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Brain-Derived Neurotrophic Factor/*genetics
Dopaminergic Neurons/*metabolism
Glial Cell Line-Derived Neurotrophic Factor/*genetics
Induced Pluripotent Stem Cells/*metabolism
Parkinson Disease/*metabolism
Receptor, trkB/*genetics
Brain-Derived Neurotrophic Factor/metabolism ; Cell Line ; Cells, Cultured ; Dopaminergic Neurons/cytology ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mutation ; Neurogenesis ; Parkinson Disease/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, trkB/metabolism
Czasopismo naukowe
Tytuł :
Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders.
Autorzy :
Chen L; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Chen Y; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Zhang C; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Jiao B; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Liang S; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Tan Q; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Chai H; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Yu W; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Qian Y; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Yang H; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Yao W; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Yu J; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Luo Y; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.
Plewe M; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.
Wang J; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Han XR; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.
Liu J; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 10; Vol. 63 (23), pp. 14562-14575. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Kinase Inhibitors/*pharmacology
Pyridazines/*pharmacology
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Thalidomide/*analogs & derivatives
Thalidomide/*pharmacology
Animals ; Cell Line, Tumor ; Down-Regulation/drug effects ; Drug Design ; Drug Discovery ; Humans ; Male ; Mice, Inbred ICR ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/pharmacokinetics ; Proteolysis/drug effects ; Pyridazines/chemical synthesis ; Pyridazines/pharmacokinetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor, trkA/antagonists & inhibitors ; Receptor, trkA/metabolism ; Receptor, trkB/antagonists & inhibitors ; Receptor, trkB/metabolism ; Receptor, trkC/antagonists & inhibitors ; Receptor, trkC/metabolism ; Structure-Activity Relationship ; Thalidomide/pharmacokinetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Low-Level Inhibition of GABAergic Synapses Enhances Gene Expressions Crucial for Neuronal Plasticity in the Hippocampus After Ischemic Stroke.
Autorzy :
Okamura M; Graduate School of Health Sciences, Hokkaido University, Kita 12 Nishi 5, Kita-ku, Sapporo 060-0812, Japan. Electronic address: .
Inoue T; Graduate School of Health Sciences, Hokkaido University, Kita 12 Nishi 5, Kita-ku, Sapporo 060-0812, Japan; Research Fellow of Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan. Electronic address: .
Takamatsu Y; Department of Rehabilitation Science, Faculty of Health Sciences, Hokkaido University, Kita 12 Nishi 5, Kita-ku, Sapporo 060-0812, Japan. Electronic address: .
Maejima H; Department of Rehabilitation Science, Faculty of Health Sciences, Hokkaido University, Kita 12 Nishi 5, Kita-ku, Sapporo 060-0812, Japan. Electronic address: .
Pokaż więcej
Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Dec; Vol. 29 (12), pp. 105316. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Bicuculline/*pharmacology
GABA-A Receptor Antagonists/*pharmacology
GABAergic Neurons/*drug effects
Hippocampus/*drug effects
Infarction, Middle Cerebral Artery/*drug therapy
Infarction, Middle Cerebral Artery/*genetics
Neural Inhibition/*drug effects
Neuronal Plasticity/*drug effects
Synaptic Transmission/*drug effects
Animals ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Disease Models, Animal ; Disks Large Homolog 4 Protein/genetics ; Disks Large Homolog 4 Protein/metabolism ; GABAergic Neurons/metabolism ; GABAergic Neurons/pathology ; Gene Expression Regulation ; Hippocampus/metabolism ; Hippocampus/pathology ; Hippocampus/physiopathology ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/physiopathology ; Male ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Rats, Sprague-Dawley ; Receptor, trkB/genetics ; Receptor, trkB/metabolism ; Receptors, Growth Factor/genetics ; Receptors, Growth Factor/metabolism ; Synaptophysin/genetics ; Synaptophysin/metabolism
Czasopismo naukowe
Tytuł :
Immunity against cancer cells may promote their proliferation and metastasis.
Autorzy :
Lin CW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Xie J; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Zhang D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Han KH; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Grande G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Wu NC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Yang Z; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Yea K; Department of New Biology, DGIST (Daegu Gyeongbuk Institute of Science and Technology), 42988 Daegu, Republic of Korea.
Lerner RA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 07; Vol. 117 (1), pp. 426-431. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoantibodies/*immunology
Autoantigens/*immunology
Breast Neoplasms/*pathology
Membrane Glycoproteins/*immunology
Neoplasm Metastasis/*immunology
Receptor, trkB/*immunology
Animals ; Autoantibodies/blood ; Autoantibodies/isolation & purification ; Autoantibodies/metabolism ; Autoantigens/blood ; Autoantigens/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Brain-Derived Neurotrophic Factor/immunology ; Brain-Derived Neurotrophic Factor/metabolism ; Breast Neoplasms/blood ; Breast Neoplasms/immunology ; Cell Line, Tumor ; Cell Movement/immunology ; Cell Proliferation ; Female ; Humans ; Membrane Glycoproteins/agonists ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/blood ; Mice ; Receptor, trkB/agonists ; Receptor, trkB/antagonists & inhibitors ; Receptor, trkB/blood ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Mixed response and mechanisms of resistance to larotrectinib in metastatic carcinoma ex pleomorphic adenoma of the parotid harboring an NTRK2 fusion: A case report.
Autorzy :
Pircher M; Onkozentrum Zürich.
Briner HR; ORL-Zentrum Klinik Hirslanden, Zurich.
Bonomo M; Clinica Luganese Moncucco, Lugano.
Horcic M; Institut für Histologische und Zytologische Diagnostik AG, Aarau.
Petrausch U; Onkozentrum Zürich.
Helbling D; Onkozentrum Zürich.
Winder T; Swiss Tumor Molecular Institute, Zurich, Switzerland.
Pokaż więcej
Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 29; Vol. 100 (4), pp. e24463.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Adenoma, Pleomorphic/*drug therapy
Parotid Neoplasms/*drug therapy
Pharyngeal Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Pyrazoles/*therapeutic use
Pyrimidines/*therapeutic use
Adenoma, Pleomorphic/genetics ; Adenoma, Pleomorphic/surgery ; Drug Resistance, Neoplasm ; Humans ; Male ; Membrane Glycoproteins ; Middle Aged ; Neoplasm Recurrence, Local ; Oncogene Proteins, Fusion/genetics ; Parotid Neoplasms/genetics ; Parotid Neoplasms/surgery ; Pharyngeal Neoplasms/genetics ; Pharyngeal Neoplasms/pathology ; Receptor, trkB
Czasopismo naukowe
Tytuł :
A Systematic Analysis Revealed the Potential Gene Regulatory Processes of ATRA-Triggered Neuroblastoma Differentiation and Identified a Novel RA Response Sequence in the NTRK2 Gene.
Autorzy :
Guo L; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Lin W; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang Y; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Wang J; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Pokaż więcej
Źródło :
BioMed research international [Biomed Res Int] 2020 Feb 19; Vol. 2020, pp. 6734048. Date of Electronic Publication: 2020 Feb 19 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Membrane Glycoproteins/*genetics
Neuroblastoma/*genetics
Neuroblastoma/*metabolism
Receptor, trkB/*genetics
Tretinoin/*metabolism
Binding Sites ; Cell Differentiation ; Cell Line, Tumor ; Gene Regulatory Networks ; Humans ; Membrane Glycoproteins/metabolism ; Neurites/metabolism ; Receptor, trkB/metabolism ; Receptors, Retinoic Acid/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
Optogenetic Modulation of TrkB Signaling in the Mouse Brain.
Autorzy :
Hong J; Department of Biological Science, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.
Heo WD; Department of Biological Science, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea; Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, 305-701, Republic of Korea; KAIST Institute for the BioCentury, KAIST, Daejeon, 305-701, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Journal of molecular biology [J Mol Biol] 2020 Feb 14; Vol. 432 (4), pp. 815-827. Date of Electronic Publication: 2020 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hippocampus/*metabolism
Receptor, trkB/*metabolism
Animals ; Axons/metabolism ; Brain/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Entorhinal Cortex/metabolism ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Optogenetics ; Promoter Regions, Genetic/genetics ; Promoter Regions, Genetic/physiology ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Receptor, trkB/genetics ; Signal Transduction/genetics ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex.
Autorzy :
Kedra M; Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland.
Banasiak K; Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland.
Kisielewska K; Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland.
Wolinska-Niziol L; Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland.
Jaworski J; Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland .
Zmorzynska J; Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 28; Vol. 117 (4), pp. 2170-2179. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anxiety/*metabolism
Epilepsy/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Receptor, trkB/*metabolism
Tuberous Sclerosis/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Anxiety/genetics ; Anxiety/psychology ; Disease Models, Animal ; Epilepsy/genetics ; Epilepsy/psychology ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Receptor, trkB/genetics ; Seizures/genetics ; Seizures/metabolism ; Seizures/psychology ; Tuberous Sclerosis/genetics ; Tuberous Sclerosis/psychology ; Zebrafish ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target.
Autorzy :
Gambella A; Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Senetta R; Pathology Unit, Department of Oncology, University of Turin, 10126 Turin, Italy.
Collemi G; Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Vallero SG; Pediatric Onco-Hematology Unit, Department of Pediatric and Public Health Sciences, University of Turin, 10126 Turin, Italy.
Monticelli M; Neurosurgery Unit, Department of Neurosciences, University of Turin, 10126 Turin, Italy.
Cofano F; Neurosurgery Unit, Department of Neurosciences, University of Turin, 10126 Turin, Italy.
Zeppa P; Neurosurgery Unit, Department of Neurosciences, University of Turin, 10126 Turin, Italy.
Garbossa D; Neurosurgery Unit, Department of Neurosciences, University of Turin, 10126 Turin, Italy.
Pellerino A; Department of Neuro-Oncology, University and City of Health and Science Hospital, 10126 Turin, Italy.
Rudà R; Department of Neuro-Oncology, University and City of Health and Science Hospital, 10126 Turin, Italy.
Soffietti R; Department of Neuro-Oncology, University and City of Health and Science Hospital, 10126 Turin, Italy.
Fagioli F; Pediatric Onco-Hematology Unit, Department of Pediatric and Public Health Sciences, University of Turin, 10126 Turin, Italy.
Papotti M; Pathology Unit, Department of Oncology, University of Turin, 10126 Turin, Italy.
Cassoni P; Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Bertero L; Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 23; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Fusion*
Central Nervous System Neoplasms/*genetics
Central Nervous System Neoplasms/*metabolism
Membrane Glycoproteins/*genetics
Protein Kinase Inhibitors/*therapeutic use
Receptor, trkA/*genetics
Receptor, trkB/*genetics
Receptor, trkC/*genetics
Animals ; Biomarkers, Tumor/genetics ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/drug therapy ; Humans ; Membrane Glycoproteins/metabolism ; Precision Medicine ; Receptor, trkA/metabolism ; Receptor, trkB/metabolism ; Receptor, trkC/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Brain-derived Neurotrophic Factor and TrkB Levels in Mice that Lack Vesicular Zinc: Effects of Age and Sex.
Autorzy :
McAllister BB; Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada; Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
Bihelek N; Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada; Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
Mychasiuk R; Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada; Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada; Alberta Children's Hospital Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
Dyck RH; Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada; Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada. Electronic address: .
Pokaż więcej
Źródło :
Neuroscience [Neuroscience] 2020 Jan 15; Vol. 425, pp. 90-100. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain-Derived Neurotrophic Factor/*metabolism
Receptor, trkB/*metabolism
Aging ; Animals ; Carrier Proteins/metabolism ; Hippocampus/metabolism ; Mice ; Mice, Knockout ; Neurons/metabolism ; Receptor, trkB/genetics ; Sex Factors ; Synapses/metabolism ; Synaptic Vesicles/metabolism ; Zinc/deficiency ; Zinc/metabolism
Czasopismo naukowe
Tytuł :
Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain.
Autorzy :
Gowler PRW; Pain Centre Versus Arthritis, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Li L; Pain Centre Versus Arthritis, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Woodhams SG; Pain Centre Versus Arthritis, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Bennett AJ; FRAME, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Suzuki R; Neusentis Ltd, Cambridge, United Kingdom.
Walsh DA; Pain Centre Versus Arthritis, Academic Rheumatology, City Hospital, University of Nottingham, Nottingham, United Kingdom.
Chapman V; Pain Centre Versus Arthritis, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Pokaż więcej
Źródło :
Pain [Pain] 2020 Jan; Vol. 161 (1), pp. 61-73.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthralgia/*metabolism
Brain-Derived Neurotrophic Factor/*metabolism
Chronic Pain/*metabolism
Membrane Glycoproteins/*metabolism
Osteoarthritis, Knee/*metabolism
Receptor, trkB/*metabolism
Synovial Membrane/*metabolism
Aged ; Animals ; Arthralgia/genetics ; Arthritis, Experimental/genetics ; Arthritis, Experimental/metabolism ; Brain-Derived Neurotrophic Factor/genetics ; Chronic Pain/genetics ; Female ; Humans ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Osteoarthritis, Knee/genetics ; Pain Measurement ; Rats ; Rats, Sprague-Dawley ; Receptor, trkB/genetics
Czasopismo naukowe
Tytuł :
The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception.
Autorzy :
Cappoli N; Università Cattolica del Sacro Cuore, Dipartimento di Sicurezza e Bioetica, Sezione di Farmacologia, Rome, Italy.
Tabolacci E; Università Cattolica del Sacro Cuore, Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Medicina Genomica, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Aceto P; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Rome, Italy; Università Cattolica del Sacro Cuore, Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Rome, Italy. Electronic address: .
Dello Russo C; Università Cattolica del Sacro Cuore, Dipartimento di Sicurezza e Bioetica, Sezione di Farmacologia, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Pokaż więcej
Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2020 Dec 15; Vol. 349, pp. 577406. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain-Derived Neurotrophic Factor/*biosynthesis
Membrane Glycoproteins/*biosynthesis
Pain Perception/*physiology
Receptor, trkB/*biosynthesis
Signal Transduction/*physiology
Animals ; Biomarkers/metabolism ; Brain-Derived Neurotrophic Factor/pharmacology ; Brain-Derived Neurotrophic Factor/therapeutic use ; Humans ; Pain Perception/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies