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Tytuł :
[Clinical and molecular pathological features of uterine inflammatory myofibroblastic tumor].
Autorzy :
Zhang Y; Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Dong W; Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Li SX; Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Zhao JJ; Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Du B; Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
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Źródło :
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2021 Sep 08; Vol. 50 (9), pp. 1020-1023.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*
Receptor Protein-Tyrosine Kinases*/genetics
Adolescent ; Adult ; Aged ; Anaplastic Lymphoma Kinase/genetics ; China ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Middle Aged ; Pregnancy ; Young Adult
Czasopismo naukowe
Tytuł :
Pancreatic Adenocarcinoma Therapeutics Targeting RTK and TGF Beta Receptor.
Autorzy :
Yang HH; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
Liu JW; Everfront Biotech Inc., New Taipei City 221, Taiwan.
Lee JH; Everfront Biotech Inc., New Taipei City 221, Taiwan.
Harn HJ; Bioinnovation Center, Tzu Chi Foundation, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.; Department of Pathology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
Chiou TW; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 29; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Carcinoma, Pancreatic Ductal/*drug therapy
Pancreatic Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Receptors, Transforming Growth Factor beta/*antagonists & inhibitors
Signal Transduction/*drug effects
Cancer-Associated Fibroblasts/metabolism ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Pancreatic Neoplasms/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptors, Transforming Growth Factor beta/metabolism ; Treatment Outcome ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Activation of Muscle-Specific Kinase (MuSK) Reduces Neuromuscular Defects in the Delta7 Mouse Model of Spinal Muscular Atrophy (SMA).
Autorzy :
Feng Z; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Lam S; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Tenn ES; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Ghosh AS; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Cantor S; Department of Neuroscience, Skirball Institute of Biomolecular Medicine, New York University, New York City, NY 10016, USA.
Zhang W; Department of Neuroscience, Skirball Institute of Biomolecular Medicine, New York University, New York City, NY 10016, USA.
Yen PF; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Chen KS; Spinal Muscular Atrophy Foundation, P.O. Box 9214, Jackson, WY 83002, USA.
Burden S; Department of Neuroscience, Skirball Institute of Biomolecular Medicine, New York University, New York City, NY 10016, USA.
Paushkin S; Spinal Muscular Atrophy Foundation, P.O. Box 9214, Jackson, WY 83002, USA.
Ayalon G; Ultragenyx Pharmaceutical, Novato, CA 94949, USA.
Ko CP; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 27; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article
MeSH Terms :
Motor Neurons/*enzymology
Muscular Atrophy, Spinal/*enzymology
Neuromuscular Junction/*enzymology
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Disease Models, Animal ; Enzyme Activation ; Mice ; Mice, Transgenic ; Motor Neurons/pathology ; Muscular Atrophy, Spinal/genetics ; Muscular Atrophy, Spinal/pathology ; Neuromuscular Junction/genetics ; Neuromuscular Junction/pathology ; Receptor Protein-Tyrosine Kinases/genetics ; Survival of Motor Neuron 1 Protein/genetics ; Survival of Motor Neuron 1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Biparatopic single-domain antibodies against Axl achieve ultra-high affinity through intramolecular engagement.
Autorzy :
Henry KA; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada.
Nguyen TD; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada.
Baral TN; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada.
Hussack G; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada.
Raphael S; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada.
Arbabi-Ghahroudi M; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada.
Robert A; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montréal, Québec, H4P 2R2, Canada.
Durocher Y; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montréal, Québec, H4P 2R2, Canada.
Wu C; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montréal, Québec, H4P 2R2, Canada.
Jaramillo ML; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montréal, Québec, H4P 2R2, Canada.
MacKenzie CR; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jul 12; Vol. 562, pp. 154-161. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody Affinity/*immunology
Receptor Protein-Tyrosine Kinases/*immunology
Single-Domain Antibodies/*immunology
Animals ; CHO Cells ; Camelids, New World ; Cell Death ; Cell Line, Tumor ; Cricetulus ; HEK293 Cells ; Humans ; Immunoglobulin Heavy Chains/immunology ; Kinetics ; Protein Binding ; Protein Domains ; Protein Multimerization ; Receptor Protein-Tyrosine Kinases/chemistry ; Recombinant Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
Folding and Intrinsic Disorder of the Receptor Tyrosine Kinase KIT Insert Domain Seen by Conventional Molecular Dynamics Simulations.
Autorzy :
Ledoux J; Centre Borelli, CNRS, ENS Paris-Saclay, Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.
Trouvé A; Centre Borelli, CNRS, ENS Paris-Saclay, Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.
Tchertanov L; Centre Borelli, CNRS, ENS Paris-Saclay, Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 09; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Amino Acid Sequence/*genetics
Receptor Protein-Tyrosine Kinases/*chemistry
Tyrosine/*chemistry
Allosteric Regulation ; Catalytic Domain ; Entropy ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Protein Conformation ; Protein Conformation, alpha-Helical ; Protein Domains ; Protein Folding ; Receptor Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł :
MDMX/MDM4 is highly expressed and contributes to cell growth and survival in anaplastic large cell lymphoma.
Autorzy :
Sinatkas V; Department of Pathology, University of Crete, Medical School, Heraklion, Greece.
Stathopoulou K; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Xagoraris I; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Ye J; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Vyrla D; Department of Pathology, University of Crete, Medical School, Heraklion, Greece.
Atsaves V; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Leventaki V; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
Medeiros LJ; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rassidakis GZ; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Drakos E; Department of Pathology, University of Crete, Medical School, Heraklion, Greece.; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2021 Jul; Vol. 62 (7), pp. 1563-1573. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphoma, Large-Cell, Anaplastic*/genetics
Proto-Oncogene Proteins*
Receptor Protein-Tyrosine Kinases*/genetics
Anaplastic Lymphoma Kinase/genetics ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Humans
Czasopismo naukowe
Tytuł :
AXL is crucial for E1A-enhanced therapeutic efficiency of EGFR tyrosine kinase inhibitors through NFI in breast cancer.
Autorzy :
Su CM; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University, Taipei City, Taiwan.
Hsu TW; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei City, Taiwan.
Sung SY; Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, New Taipei City, Taiwan.
Huang MT; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University, Taipei City, Taiwan.
Chen KC; Department of sport and physical education, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
Huang CY; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Chiang CY; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Su YH; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University, Taipei City, Taiwan.
Chen HA; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University, Taipei City, Taiwan.
Liao PH; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Jul; Vol. 36 (7), pp. 1278-1287. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Receptor Protein-Tyrosine Kinases*/genetics
Cell Line, Tumor ; Drug Resistance, Neoplasm ; ErbB Receptors/genetics ; Humans ; NFI Transcription Factors ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins/genetics
Czasopismo naukowe
Tytuł :
Oncogenic signaling of RTK fusions becomes more granular.
Autorzy :
Cuneo MJ; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mittag T; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jun 17; Vol. 81 (12), pp. 2504-2506.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Receptor Protein-Tyrosine Kinases*/genetics
Receptor Protein-Tyrosine Kinases*/metabolism
Signal Transduction*
Carcinogenesis ; Humans ; Oncogenes/genetics ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
All Good Things Must End: Termination of Receptor Tyrosine Kinase Signal.
Autorzy :
Margiotta A; Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 65691 Brno, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 14; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Signal Transduction*
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Down-Regulation ; Humans ; Lysosomes/metabolism ; Mutation/genetics ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis-New insight and futuristic vision.
Autorzy :
Huang XL; School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China.
Khan MI; Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: .
Wang J; First Affiliated Hospital of University of Science and Technology of China Hefei, Anhui 230036, China.
Ali R; Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China.
Ali SW; Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China.
Zahra QU; Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China.
Kazmi A; Department of Pathology, Al-Nafees Medical College and Hospital, Isra University, Islamabad 45600, Pakistan.
Lolai A; School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China.
Huang YL; School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China.
Hussain A; Department of Laboratory Medicine, Karolinska Institutet, Karolinska Hospital, Huddinge, SE 141 86 Stockholm, Sweden; Department of Biosciences, COMSATS Institute of Information Technology, Chak Shahzad Campus, Islamabad 44000, Pakistan.
Bilal M; School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China.
Li F; Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: .
Qiu B; Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 01; Vol. 180, pp. 739-752. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Neoplasms/*genetics
Neovascularization, Pathologic/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
Signal Transduction/*genetics
Animals ; Disease Progression ; Humans ; Mutation ; Neoplasms/blood supply ; Neoplasms/metabolism ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/prevention & control ; Protein Kinase Inhibitors/therapeutic use ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Breaking Oncogene Addiction: Getting RTK/RAS-Mutated Cancers off the SOS.
Autorzy :
Sheffels E; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, United States.
Kortum RL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 27; Vol. 64 (10), pp. 6566-6568. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Receptor Protein-Tyrosine Kinases/*metabolism
SOS1 Protein/*metabolism
ras Proteins/*metabolism
Drug Resistance, Neoplasm/drug effects ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/genetics ; SOS1 Protein/antagonists & inhibitors ; Signal Transduction/drug effects ; ras Proteins/antagonists & inhibitors ; ras Proteins/genetics
Czasopismo naukowe
Tytuł :
TAM kinases as regulators of cell death.
Autorzy :
Post SM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America; Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
DiNardo C; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Khoury JD; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Ruvolo PP; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America; Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 May; Vol. 1868 (6), pp. 118992. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Death*
Immunity*
Receptor Protein-Tyrosine Kinases/*immunology
Virus Diseases/*immunology
Animals ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/metabolism ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/metabolism ; Mutation ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Virus Diseases/genetics ; Virus Diseases/metabolism
Czasopismo naukowe
Tytuł :
Axl is related to inflammation in hemodialysis patients.
Autorzy :
Li M; Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai, 200072, China.
Xue W; Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai, 200072, China.
Li X; Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai, 200072, China.
Song Y; Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai, 200072, China.
Liu X; Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai, 200072, China. Electronic address: .
Qin L; Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai, 200072, China. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 May; Vol. 133, pp. 146-153. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*pathology
Intercellular Signaling Peptides and Proteins/*metabolism
Proto-Oncogene Proteins/*blood
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*blood
Receptor Protein-Tyrosine Kinases/*metabolism
Renal Dialysis/*adverse effects
ADAM10 Protein/metabolism ; ADAM17 Protein/metabolism ; Adult ; Amyloid Precursor Protein Secretases/metabolism ; B-Lymphocytes/metabolism ; Female ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Intercellular Signaling Peptides and Proteins/blood ; Interferon-gamma/blood ; Interleukin-6/blood ; Leukocytes, Mononuclear/metabolism ; Male ; Membrane Proteins/metabolism ; Middle Aged ; Proto-Oncogene Proteins/genetics ; Real-Time Polymerase Chain Reaction ; Receptor Protein-Tyrosine Kinases/genetics ; STAT1 Transcription Factor/metabolism ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Tumor Necrosis Factor-alpha/blood
Czasopismo naukowe
Tytuł :
Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer's Disease (Mouse Model) through Autophagy Induced by Activating Axl.
Autorzy :
Qi LF; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Liu S; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.
Liu YC; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Li P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Xu X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 24; Vol. 22 (11). Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Autophagy/*drug effects
Heptanoic Acids/*pharmacology
Lanosterol/*analogs & derivatives
Microglia/*drug effects
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagy/genetics ; Cell Line ; Disease Models, Animal ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Immunohistochemistry ; Lanosterol/pharmacology ; Lysosomes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/metabolism ; Microglia/pathology ; Morris Water Maze Test/drug effects ; Phosphorylation ; Proto-Oncogene Proteins/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/drug effects ; Signal Transduction/genetics ; p21-Activated Kinases/antagonists & inhibitors ; p21-Activated Kinases/metabolism
Czasopismo naukowe
Tytuł :
A pan-cancer analysis of the HER family gene and their association with prognosis, tumor microenvironment, and therapeutic targets.
Autorzy :
Yang X; Department of Otorhinolaryngology Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou City, Gansu Province, PR China.
Miao Y; The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, PR China. Electronic address: .
Wang J; The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, PR China.
Mi D; The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, PR China; Gansu Academy of Traditional Chinese Medicine, Lanzhou City, Gansu Province, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 May 15; Vol. 273, pp. 119307. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Tumor Microenvironment*
Antineoplastic Agents/*therapeutic use
Biomarkers, Tumor/*metabolism
Neoplasms/*pathology
Receptor Protein-Tyrosine Kinases/*metabolism
Biomarkers, Tumor/genetics ; Computational Biology ; Gene Expression Profiling ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Prognosis ; Receptor Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł :
The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer.
Autorzy :
Purcaru OS; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Artene SA; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Barcan E; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Silosi CA; Department of Surgery, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Stanciu I; 'Victor Babeş' Clinical Hospital of Infectious Diseases and Pneumophtisiology, Craiova, Str. Calea Bucuresti, nr. 126, 200525 Craiova, Romania.
Danoiu S; Department of Physiopathology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Tudorache S; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy Craiova, 710204 Craiova, Romania.
Tataranu LG; Department of Neurosurgery, 'Bagdasar-Arseni' Emergency Hospital, Soseaua Berceni 12, 041915 Bucharest, Romania.
Dricu A; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 02; Vol. 22 (9). Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
COVID-19/*metabolism
Neoplasms/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
SARS-CoV-2/*metabolism
Signal Transduction/*drug effects
Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/complications ; Drug Repositioning ; ErbB Receptors/metabolism ; Humans ; Middle East Respiratory Syndrome Coronavirus/metabolism ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/virology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Cholesterol-recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case of TRKB.
Autorzy :
Cannarozzo C; Neuroscience Center - HiLife, University of Helsinki, Helsinki, Finland.
Fred SM; Neuroscience Center - HiLife, University of Helsinki, Helsinki, Finland.
Girych M; Department of Physics, University of Helsinki, Helsinki, Finland.
Biojone C; Neuroscience Center - HiLife, University of Helsinki, Helsinki, Finland.
Enkavi G; Department of Physics, University of Helsinki, Helsinki, Finland.
Róg T; Department of Physics, University of Helsinki, Helsinki, Finland.
Vattulainen I; Department of Physics, University of Helsinki, Helsinki, Finland.; Computational Physics Laboratory, Tampere University, Tampere, Finland.
Casarotto PC; Neuroscience Center - HiLife, University of Helsinki, Helsinki, Finland.
Castrén E; Neuroscience Center - HiLife, University of Helsinki, Helsinki, Finland.
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2021 May; Vol. 53 (10), pp. 3311-3322. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol*
Receptor Protein-Tyrosine Kinases*
Animals ; Brain-Derived Neurotrophic Factor ; Cell Membrane ; Humans ; Ligands ; Mice ; Protein Domains ; Receptor, trkB
Czasopismo naukowe
Tytuł :
Pathogenic postzygotic mosaicism in the tyrosine receptor kinase pathway: potential unidentified human disease hidden away in a few cells.
Autorzy :
Tiemann-Boege I; Institute of Biophysics, Johannes Kepler University, Linz, Austria.
Mair T; Institute of Biophysics, Johannes Kepler University, Linz, Austria.
Yasari A; Institute of Biophysics, Johannes Kepler University, Linz, Austria.
Zurovec M; Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice, Czech Republic.
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Źródło :
The FEBS journal [FEBS J] 2021 May; Vol. 288 (10), pp. 3108-3119. Date of Electronic Publication: 2020 Sep 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Germ-Line Mutation*
Mosaicism*
Fibrous Dysplasia, Polyostotic/*genetics
Proteus Syndrome/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
Sturge-Weber Syndrome/*genetics
Child ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Embryo, Mammalian ; Fibrous Dysplasia, Polyostotic/enzymology ; Fibrous Dysplasia, Polyostotic/pathology ; Gene Expression ; Genes, Lethal ; Humans ; Infant ; Infant, Newborn ; Phenotype ; Proteus Syndrome/enzymology ; Proteus Syndrome/pathology ; Receptor Protein-Tyrosine Kinases/deficiency ; Signal Transduction ; Sturge-Weber Syndrome/enzymology ; Sturge-Weber Syndrome/pathology
Czasopismo naukowe
Tytuł :
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor.
Autorzy :
Zhang H; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China.
Peng X; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
Dai Y; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
Shao J; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China.
Ji Y; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
Sun Y; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
Liu B; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
Cheng X; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China.
Ai J; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China.
Duan W; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3956-3975. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Proto-Oncogene Proteins/*antagonists & inhibitors
Pyrimidinones/*therapeutic use
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Amino Acid Sequence ; Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Humans ; Male ; Mice, Inbred ICR ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/metabolism ; Proto-Oncogene Proteins/metabolism ; Pyrimidinones/chemical synthesis ; Pyrimidinones/metabolism ; Rats, Sprague-Dawley ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction/drug effects ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade.
Autorzy :
Boshuizen J; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Pencheva N; Genmab, Utrecht, the Netherlands.
Krijgsman O; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Altimari DD; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Castro PG; Genmab, Utrecht, the Netherlands.
de Bruijn B; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Ligtenberg MA; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Gresnigt-Van den Heuvel E; Genmab, Utrecht, the Netherlands.
Vredevoogd DW; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Song JY; Division of Animal Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Visser N; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Apriamashvili G; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Janmaat ML; Genmab, Utrecht, the Netherlands.
Plantinga TS; Genmab, Utrecht, the Netherlands.
Franken P; Genmab, Utrecht, the Netherlands.
Houtkamp M; Genmab, Utrecht, the Netherlands.
Lingnau A; Genmab, Utrecht, the Netherlands.
Jure-Kunkel M; Genmab, Princeton, New Jersey.
Peeper DS; Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands. .
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Źródło :
Cancer research [Cancer Res] 2021 Apr 01; Vol. 81 (7), pp. 1775-1787. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Checkpoint Inhibitors/*therapeutic use
Immunoconjugates/*therapeutic use
Lung Neoplasms/*therapy
Melanoma/*therapy
Proto-Oncogene Proteins/*immunology
Receptor Protein-Tyrosine Kinases/*immunology
Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Line, Tumor ; Combined Modality Therapy ; Drug Resistance, Neoplasm/immunology ; Drug Synergism ; HEK293 Cells ; Humans ; Immune Checkpoint Inhibitors/administration & dosage ; Immunoconjugates/administration & dosage ; Immunotherapy ; Lung Neoplasms/pathology ; Male ; Melanoma/pathology ; Mice ; Mice, Nude ; Mice, Transgenic ; Molecular Targeted Therapy/methods ; Proto-Oncogene Proteins/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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