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Tytuł:
The TAM Subfamily of Receptor Tyrosine Kinases: The Early Years.
Autorzy:
Prieto AL; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
Lai C; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.; Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 16; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Axl Receptor Tyrosine Kinase*
Proto-Oncogene Proteins*/genetics
c-Mer Tyrosine Kinase/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/chemistry ; Tamoxifen ; Tyrosine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors.
Autorzy:
Apostolo D; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
D'Onghia D; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Tonello S; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Minisini R; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Baricich A; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Gramaglia C; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Patrucco F; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Zeppegno P; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Acquaviva A; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Balbo PE; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Castello LM; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Unit of Internal Medicine, Azienda Ospedaliera 'SS Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy.
Cappellano G; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Chiocchetti A; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Gerevini C; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Giordano M; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Laaguid F; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Manfredi M; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Raineri D; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Rigamonti C; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Rolla R; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Romano V; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Confalonieri M; Pulmonology Department, University of Trieste, 34128 Trieste, Italy.
Savoia P; Department of Health Science, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Zavattaro E; Department of Health Science, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Pirisi M; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Ruaro B; Pulmonology Department, University of Trieste, 34128 Trieste, Italy.
Sainaghi PP; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
Bellan M; Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; Center for Autoimmune and Allergic Disease (CAAD), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.; A.O.U. Maggiore della Carità, 28100 Novara, Italy.
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Corporate Authors:
No-More COVID Group
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 26; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 26.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
COVID-19*/complications
Proto-Oncogene Proteins*
Female ; Humans ; c-Mer Tyrosine Kinase ; Intercellular Signaling Peptides and Proteins ; Receptor Protein-Tyrosine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer.
Autorzy:
Iida M; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, 1111 highland Ave, WIMR 3159, Madison, WI, 53705, USA.
McDaniel NK; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, 1111 highland Ave, WIMR 3159, Madison, WI, 53705, USA.
Kostecki KL; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, 1111 highland Ave, WIMR 3159, Madison, WI, 53705, USA.
Welke NB; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, 1111 highland Ave, WIMR 3159, Madison, WI, 53705, USA.
Kranjac CA; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, 1111 highland Ave, WIMR 3159, Madison, WI, 53705, USA.
Liu P; School of Medicine and Public Health, University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Longhurst C; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Bruce JY; School of Medicine and Public Health, University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Hong S; Pharmaceutical Sciences Division, University of Wisconsin School of Pharmacy, Madison, WI, USA.; Wisconsin Center for NanoBioSystems, University of Wisconsin, Madison, WI, USA.; Yonsei Frontier Lab, Department of Pharmacy, Yonsei University, Seoul, Korea.
Salgia R; Department of Medical Oncology and Experimental Therapeutics, Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.
Wheeler DL; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, 1111 highland Ave, WIMR 3159, Madison, WI, 53705, USA. .; School of Medicine and Public Health, University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. .; Wisconsin Center for NanoBioSystems, University of Wisconsin, Madison, WI, USA. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Apr 23; Vol. 22 (1), pp. 447. Date of Electronic Publication: 2022 Apr 23.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Resistance, Neoplasm*/genetics
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/genetics
Neuregulin-1*/genetics
Neuregulin-1*/metabolism
Proto-Oncogene Proteins*/genetics
Proto-Oncogene Proteins*/metabolism
Receptor Protein-Tyrosine Kinases*/genetics
Receptor Protein-Tyrosine Kinases*/metabolism
Cell Line, Tumor ; Cetuximab/pharmacology ; Cetuximab/therapeutic use ; ErbB Receptors ; Humans ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma.
Autorzy:
Scherschinski L; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Prem M; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Department of Neurosurgery, Technische Universität Dresden, 01069 Dresden, Germany.
Kremenetskaia I; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Tinhofer I; Department of Radiooncology and Radiotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung-DKTK), Partner Site Berlin, 10115 Berlin, Germany.
Vajkoczy P; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Karbe AG; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Onken JS; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung-DKTK), Partner Site Berlin, 10115 Berlin, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 17; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
Benzocycloheptenes/*pharmacology
Brain Neoplasms/*genetics
Drug Resistance, Neoplasm/*drug effects
Glioblastoma/*genetics
Proto-Oncogene Proteins/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
Temozolomide/*pharmacology
Triazoles/*pharmacology
Brain Neoplasms/metabolism ; Brain Neoplasms/therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Combined Modality Therapy ; Drug Resistance, Neoplasm/radiation effects ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/radiation effects ; Glioblastoma/metabolism ; Glioblastoma/therapy ; Humans ; Proto-Oncogene Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction/drug effects ; Signal Transduction/radiation effects ; Tumor Hypoxia/drug effects ; Tumor Hypoxia/radiation effects ; Up-Regulation/drug effects ; Up-Regulation/radiation effects ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model.
Autorzy:
Chen TJ; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Mydel P; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Microbiology, Jagiellonian University, Krakow, Poland.
Benedyk-Machaczka M; Department of Microbiology, Jagiellonian University, Krakow, Poland.
Kamińska M; Department of Microbiology, Jagiellonian University, Krakow, Poland.
Kalucka U; Department of Microbiology, Jagiellonian University, Krakow, Poland.
Blø M; BerGenBio ASA, Bergen, Norway.
Furriol J; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Gausdal G; BerGenBio ASA, Bergen, Norway.
Lorens J; Department of Biomedicine, Centre for Cancer Biomarkers, Norwegian Centre of Excellence, University of Bergen, Bergen, Norway.
Osman T; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Marti HP; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Department of Medicine, Haukeland University Hospital, Bergen, Norway.
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Źródło:
Physiological reports [Physiol Rep] 2021 Dec; Vol. 9 (23), pp. e15140.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Renal Cell/*metabolism
Kidney Neoplasms/*metabolism
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Benzocycloheptenes/pharmacology ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Disease Progression ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Mice ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Signal Transduction/drug effects ; Triazoles/pharmacology ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AXL, along with PROS1, is overexpressed in papillary thyroid carcinoma and regulates its biological behaviour.
Autorzy:
Wei M; Department of General Surgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Zhejiang Province, Ningbo, China.
Wang Y; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Liu Y; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Li D; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
He X; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China. .
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Źródło:
World journal of surgical oncology [World J Surg Oncol] 2022 Oct 06; Vol. 20 (1), pp. 334. Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Thyroid Neoplasms*/pathology
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Apoptosis ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Ligands ; Protein S/metabolism ; Sincalide/metabolism ; Thyroid Cancer, Papillary/pathology ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis.
Autorzy:
Sun LW; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.
Kao SH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Jhang SW; Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.; Department of Veterinary Medicine, National Chung Hsing University, Taichung 40201, Taiwan.
Lin YC; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Chen CM; Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; College of Nursing and Health Sciences, Dayeh University, Changhua 51591, Taiwan.
Hsieh YH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
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Źródło:
Cells [Cells] 2021 Oct 28; Vol. 10 (11). Date of Electronic Publication: 2021 Oct 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteolysis*/drug effects
Signal Transduction*/drug effects
Glioblastoma/*pathology
Intercellular Signaling Peptides and Proteins/*metabolism
Janus Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Triterpenes/*pharmacology
Ubiquitin-Protein Ligases/*metabolism
Actins/metabolism ; Animals ; Apoptosis/drug effects ; Astrocytes/drug effects ; Astrocytes/pathology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Cytoskeleton/drug effects ; Cytoskeleton/metabolism ; Glioblastoma/metabolism ; Intercellular Signaling Peptides and Proteins/chemistry ; Molecular Docking Simulation ; Neoplasm Invasiveness ; Proteasome Endopeptidase Complex/metabolism ; Proto-Oncogene Proteins/chemistry ; Rats ; Receptor Protein-Tyrosine Kinases/chemistry ; Triterpenes/chemistry ; Tumor Stem Cell Assay ; Ubiquitin/metabolism ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
STAT1/SOCS1/3 Are Involved in the Inflammation-Regulating Effect of GAS6/AXL in Periodontal Ligament Cells Induced by Porphyromonas gingivalis Lipopolysaccharide In Vitro .
Autorzy:
Zhang S; Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Liu Y; Department of General Dentistry II, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Wang X; Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
An N; Department of General Dentistry II, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Ouyang X; Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
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Źródło:
Journal of immunology research [J Immunol Res] 2021 Oct 25; Vol. 2021, pp. 9577695. Date of Electronic Publication: 2021 Oct 25 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Periodontitis/*immunology
Porphyromonas gingivalis/*immunology
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Cell Line ; Gene Knockdown Techniques ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Lipopolysaccharides/immunology ; Periodontal Ligament/cytology ; Periodontal Ligament/immunology ; Periodontal Ligament/microbiology ; Periodontal Ligament/pathology ; Periodontitis/microbiology ; Periodontitis/pathology ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; STAT1 Transcription Factor/metabolism ; Signal Transduction/genetics ; Signal Transduction/immunology ; Suppressor of Cytokine Signaling 1 Protein/metabolism ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry.
Autorzy:
Kirui J; Centre for Experimental and Clinical Infection Research, TWINCORE, Institute for Experimental Virology, a Joint Venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30625 Hannover, Germany.; Department of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Abidine Y; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, 90185 Umeå, Sweden.
Lenman A; Centre for Experimental and Clinical Infection Research, TWINCORE, Institute for Experimental Virology, a Joint Venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30625 Hannover, Germany.; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.
Islam K; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.
Gwon YD; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.
Lasswitz L; Centre for Experimental and Clinical Infection Research, TWINCORE, Institute for Experimental Virology, a Joint Venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30625 Hannover, Germany.; Department of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Evander M; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.
Bally M; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, 90185 Umeå, Sweden.
Gerold G; Centre for Experimental and Clinical Infection Research, TWINCORE, Institute for Experimental Virology, a Joint Venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30625 Hannover, Germany.; Department of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, 90185 Umeå, Sweden.
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Źródło:
Cells [Cells] 2021 Jul 20; Vol. 10 (7). Date of Electronic Publication: 2021 Jul 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Internalization*/drug effects
Chikungunya virus/*genetics
Hepatitis A Virus Cellular Receptor 1/*genetics
Host-Pathogen Interactions/*genetics
Proto-Oncogene Proteins/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
Receptors, Virus/*genetics
Animals ; Antibodies, Monoclonal/pharmacology ; CHO Cells ; Cell Line ; Cell Line, Tumor ; Chikungunya virus/drug effects ; Chikungunya virus/growth & development ; Chikungunya virus/immunology ; Chlorocebus aethiops ; Cricetulus ; Endosomes/drug effects ; Endosomes/immunology ; Endosomes/metabolism ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Fibroblasts/immunology ; Fibroblasts/virology ; Gene Expression ; HEK293 Cells ; Hepatitis A Virus Cellular Receptor 1/antagonists & inhibitors ; Hepatitis A Virus Cellular Receptor 1/immunology ; Hepatocytes/immunology ; Hepatocytes/virology ; Host-Pathogen Interactions/immunology ; Humans ; Keratinocytes/immunology ; Keratinocytes/virology ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/immunology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/immunology ; Receptors, Virus/antagonists & inhibitors ; Receptors, Virus/immunology ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Transgenes ; Vero Cells ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MDMX/MDM4 is highly expressed and contributes to cell growth and survival in anaplastic large cell lymphoma.
Autorzy:
Sinatkas V; Department of Pathology, University of Crete, Medical School, Heraklion, Greece.
Stathopoulou K; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Xagoraris I; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Ye J; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Vyrla D; Department of Pathology, University of Crete, Medical School, Heraklion, Greece.
Atsaves V; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Leventaki V; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
Medeiros LJ; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rassidakis GZ; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Drakos E; Department of Pathology, University of Crete, Medical School, Heraklion, Greece.; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2021 Jul; Vol. 62 (7), pp. 1563-1573. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lymphoma, Large-Cell, Anaplastic*/genetics
Proto-Oncogene Proteins*
Receptor Protein-Tyrosine Kinases*/genetics
Anaplastic Lymphoma Kinase/genetics ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gas6 expression and Tyrosine kinase Axl Sky receptors: Their relation with tumor stage and grade in patients with bladder cancer.
Autorzy:
Akgül M; Department of Urology, Tekirdag Namık Kemal University Medical School, Tekirdag. .
Baykan Ö; Department of Biochemistry, Balıkesir University Medical School, Balıkesir. .
Çağman Z; Department of Biochemistry, Bezmialem University, School of Pharmacy, Istanbul. .
Özyürek M; Department of Physiology, Marmara University, School of Medicine, Istanbul. .
Tinay İ; Anadolu Medical Center, Gebze, Kocaeli. .
Akbal C; Department of Urology, Acıbadem University, School of Medicine, Istanbul. .
Uras F; Department of Biochemistry, Marmara University, School of Pharmacy, Istanbul. .
Türkeri L; Department of Urology, Acıbadem University, School of Medicine, Istanbul. .
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Źródło:
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica [Arch Ital Urol Androl] 2021 Jun 28; Vol. 93 (2), pp. 148-152. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Urinary Bladder Neoplasms*/genetics
Intercellular Signaling Peptides and Proteins/*metabolism
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins/genetics ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer's Disease (Mouse Model) through Autophagy Induced by Activating Axl.
Autorzy:
Qi LF; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Liu S; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.
Liu YC; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Li P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Xu X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 24; Vol. 22 (11). Date of Electronic Publication: 2021 May 24.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*drug therapy
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Autophagy/*drug effects
Heptanoic Acids/*pharmacology
Lanosterol/*analogs & derivatives
Microglia/*drug effects
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagy/genetics ; Cell Line ; Disease Models, Animal ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Immunohistochemistry ; Lanosterol/pharmacology ; Lysosomes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/metabolism ; Microglia/pathology ; Morris Water Maze Test/drug effects ; Phosphorylation ; Proto-Oncogene Proteins/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/drug effects ; Signal Transduction/genetics ; p21-Activated Kinases/antagonists & inhibitors ; p21-Activated Kinases/metabolism ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.
Autorzy:
Sainaghi PP; Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy.; Division of Rheumatology, CAAD (Center for Translational Research on Autoimmune and Allergic Diseases) 'AOU Maggiore della Carità', Novara, Italy.; IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, Novara, Italy.
Bellan M; Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy.; Division of Rheumatology, CAAD (Center for Translational Research on Autoimmune and Allergic Diseases) 'AOU Maggiore della Carità', Novara, Italy.; IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, Novara, Italy.
Nerviani A; IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, Novara, Italy.; Experimental Medicine and Rheumatology, William Harvey Research Institute and Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Źródło:
Disease markers [Dis Markers] 2021 Jan 13; Vol. 2021, pp. 2854925. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).
Typ publikacji:
Editorial
MeSH Terms:
Molecular Targeted Therapy*
Intercellular Signaling Peptides and Proteins/*genetics
Proto-Oncogene Proteins/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
c-Mer Tyrosine Kinase/*genetics
Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Biomarkers/metabolism ; Gene Expression ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/immunology ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/immunology ; Immunologic Factors/therapeutic use ; Intercellular Signaling Peptides and Proteins/immunology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Liver Cirrhosis/immunology ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/immunology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/immunology ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/drug therapy ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/immunology ; c-Mer Tyrosine Kinase/antagonists & inhibitors ; c-Mer Tyrosine Kinase/immunology ; Axl Receptor Tyrosine Kinase
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AXL Receptor in Breast Cancer: Molecular Involvement and Therapeutic Limitations.
Autorzy:
Falcone I; Medical Oncology 1, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Conciatori F; Medical Oncology 1, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Bazzichetto C; Medical Oncology 1, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Bria E; U.O.C. Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Carbognin L; Department of Woman & Child Health, Division of Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Malaguti P; Medical Oncology 1, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Ferretti G; Medical Oncology 1, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Cognetti F; Medical Oncology 1, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Milella M; Section of Oncology, Department of Medicine, University of Verona School of Medicine and Verona University Hospital Trust, 37126 Verona, Italy.
Ciuffreda L; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Breast Neoplasms/*physiopathology
Proto-Oncogene Proteins/*physiology
Receptor Protein-Tyrosine Kinases/*physiology
Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/physiology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Cell Movement/genetics ; Cell Movement/physiology ; Drug Resistance, Neoplasm ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Epithelial-Mesenchymal Transition/physiology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Intercellular Signaling Peptides and Proteins/chemistry ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/physiology ; Molecular Targeted Therapy/methods ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/physiopathology ; Protein Kinase Inhibitors/therapeutic use ; Protein Processing, Post-Translational ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/genetics ; Tumor Microenvironment/genetics ; Tumor Microenvironment/physiology ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of an AXL kinase inhibitor in triple-negative breast cancer by structure-based virtual screening and bioactivity test.
Autorzy:
Li P; The First Affiliated Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.; Key Laboratory of Oncology and Molecular Pathology of Hunan Province, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Niu Y; School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China.
Li S; College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, China.
Zu X; The First Affiliated Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.; Key Laboratory of Oncology and Molecular Pathology of Hunan Province, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Xiao M; The First Affiliated Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.; Key Laboratory of Oncology and Molecular Pathology of Hunan Province, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Yin L; The First Affiliated Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.; Key Laboratory of Oncology and Molecular Pathology of Hunan Province, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Feng J; The First Affiliated Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.; Key Laboratory of Oncology and Molecular Pathology of Hunan Province, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
He J; The Nanhua Affiliated Hospital, Department of Spine Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shen Y; The First Affiliated Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.; Key Laboratory of Oncology and Molecular Pathology of Hunan Province, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2022 Feb; Vol. 99 (2), pp. 222-232. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins/*antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Triple Negative Breast Neoplasms/*diagnosis
Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Early Detection of Cancer ; Female ; High-Throughput Screening Assays ; Humans ; Molecular Dynamics Simulation ; Molecular Structure ; Phosphorylation ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/chemistry ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AXL Knock-Out in SNU475 Hepatocellular Carcinoma Cells Provides Evidence for Lethal Effect Associated with G2 Arrest and Polyploidization.
Autorzy:
Batur T; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir 35330, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir 35330, Turkey.
Argundogan A; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir 35330, Turkey.; School of Medicine, Dokuz Eylul University, Izmir 35340, Turkey.
Keles U; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir 35330, Turkey.
Mutlu Z; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir 35330, Turkey.
Alotaibi H; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir 35330, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir 35330, Turkey.
Senturk S; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir 35330, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir 35330, Turkey.
Ozturk M; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir 35330, Turkey.; Galen Research Center, Izmir Tinaztepe University, Izmir 35400, Turkey.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 09; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Up-Regulation*
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
Proto-Oncogene Proteins/*genetics
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*genetics
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Benzocycloheptenes ; CRISPR-Cas Systems ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; G2 Phase Cell Cycle Checkpoints ; Gene Expression Regulation, Neoplastic ; Gene Knockout Techniques ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Neoplasm Transplantation ; Phenotype ; Triazoles ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma.
Autorzy:
Ruicci KM; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.; Department of Pathology & Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Meens J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Plantinga P; Department of Pathology & Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Stecho W; Department of Pathology & Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Pinto N; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.
Yoo J; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.; Department of Oncology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Fung K; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.; Department of Oncology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
MacNeil D; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.; Department of Oncology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Mymryk JS; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.; Department of Oncology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Barrett JW; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.
Howlett CJ; Department of Pathology & Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Boutros PC; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, USA.
Ailles L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Nichols AC; Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, Room B3-431A, 800 Commissioners Road East, London, ON, N6A 5W9, Canada. .; Department of Pathology & Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. .; Department of Oncology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 Oct 15; Vol. 39 (1), pp. 217. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Resistance, Neoplasm*
MAP Kinase Signaling System*
Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors
Gene Expression Regulation, Neoplastic/*drug effects
Head and Neck Neoplasms/*drug therapy
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Thiazoles/*pharmacology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Movement ; Cell Proliferation ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Mice ; Prognosis ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role of Receptor Tyrosine Kinases in Lassa Virus Cell Entry.
Autorzy:
Fedeli C; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
Moreno H; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
Kunz S; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
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Źródło:
Viruses [Viruses] 2020 Aug 06; Vol. 12 (8). Date of Electronic Publication: 2020 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Internalization*/drug effects
Lassa virus/*physiology
Proto-Oncogene Proteins/*metabolism
Proto-Oncogene Proteins c-met/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Receptors, Virus/*metabolism
Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Benzocycloheptenes/pharmacology ; Benzocycloheptenes/therapeutic use ; Cell Line, Tumor ; Cell Membrane/metabolism ; Drug Interactions ; Dystroglycans/metabolism ; Glycosylation ; Humans ; Lassa Fever/drug therapy ; Lassa Fever/virology ; Lassa virus/drug effects ; Pinocytosis ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased serum AXL is associated with radiographic knee osteoarthritis severity.
Autorzy:
Zhenghai S; Shanghai Kaiyuan Orthopedic Hospital, Shanghai, China.
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Źródło:
International journal of rheumatic diseases [Int J Rheum Dis] 2022 Jan; Vol. 25 (1), pp. 32-37. Date of Electronic Publication: 2021 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
Osteoarthritis, Knee/*blood
Proto-Oncogene Proteins/*blood
Receptor Protein-Tyrosine Kinases/*blood
Aged ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee/diagnostic imaging ; Radiography ; Severity of Illness Index ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Duplication and divergence: New insights into AXR1 and AXL functions in DNA repair and meiosis.
Autorzy:
Martinez-Garcia M; Departamento de Genética, Fisiología y Microbiología. Facultad de Biología, Universidad Complutense de Madrid, Madrid, 28040, Spain.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA.
Fernández-Jiménez N; Departamento de Genética, Fisiología y Microbiología. Facultad de Biología, Universidad Complutense de Madrid, Madrid, 28040, Spain.
Santos JL; Departamento de Genética, Fisiología y Microbiología. Facultad de Biología, Universidad Complutense de Madrid, Madrid, 28040, Spain.
Pradillo M; Departamento de Genética, Fisiología y Microbiología. Facultad de Biología, Universidad Complutense de Madrid, Madrid, 28040, Spain. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 01; Vol. 10 (1), pp. 8860. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Repair*
Meiosis*
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; DNA Damage/radiation effects ; Gamma Rays ; Gene Expression Regulation, Plant ; Homologous Recombination ; Indoleacetic Acids/metabolism ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Promoter Regions, Genetic ; Proto-Oncogene Proteins/deficiency ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/deficiency ; Receptor Protein-Tyrosine Kinases/genetics ; Ubiquitination ; Axl Receptor Tyrosine Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 412

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