Temat: "Receptor Protein-Tyrosine Kinases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The Configuration of GRB2 in Protein Interaction and Signal Transduction.
Autorzy:: Wang D; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Liu G; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.; School of Life Science, Tianjin University, Tianjin 200072, China.
Meng Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Chen H; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Ye Z; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.; Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Hangzhou 310022, China.
Jing J; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.; Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Hangzhou 310022, China.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2024 Feb 22; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Signal Transduction*
Receptor Protein-Tyrosine Kinases*/metabolism
GRB2 Adaptor Protein/metabolism ; Tyrosine/metabolism ; Receptors, Cell Surface/metabolism ; Son of Sevenless Proteins ; Protein Binding ; Phosphorylation

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Skocz do pozycji: 2.

Tytuł:: Computational evidence for multi-layer crosstalk between the cadherin-11 and PDGFR pathways.
Autorzy:: Karagöz Z; Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Passanha FR; Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Robeerst L; Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
van Griensven M; Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
LaPointe VLS; Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Carlier A; Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Sep 22; Vol. 13 (1), pp. 15804. Date of Electronic Publication: 2023 Sep 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Cadherins*
Signal Transduction*
Humans ; Receptor Protein-Tyrosine Kinases ; Platelet-Derived Growth Factor ; Receptor, Platelet-Derived Growth Factor beta/genetics

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Skocz do pozycji: 3.

Tytuł:: Imaging strategies for receptor tyrosine kinase dimers in living cells.
Autorzy:: Zhang X; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, People's Republic of China.
Yin J; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, People's Republic of China.
Pan W; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, People's Republic of China.
Li Y; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, People's Republic of China. .
Li N; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, People's Republic of China. .
Tang B; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, People's Republic of China.; Pokaż więcej
Źródło:: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2023 Jan; Vol. 415 (1), pp. 67-82. Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Receptor Protein-Tyrosine Kinases*/metabolism
Signal Transduction*
Dimerization

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Skocz do pozycji: 4.

Tytuł:: The Structure, Function and Regulation of Protein Tyrosine Phosphatase Receptor Type J and Its Role in Diseases.
Autorzy:: Li H; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Zhang P; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Liu C; People's Hospital of Zhongjiang County, Deyang 618100, China.
Wang Y; Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Deng Y; Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Dong W; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Yu Y; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.; Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Dec 20; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 20.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
Receptor Protein-Tyrosine Kinases*
Mice ; Animals ; Phosphorylation ; Protein Tyrosine Phosphatases ; Cell Line

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Skocz do pozycji: 5.

Tytuł:: Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis.
Autorzy:: Sun LW; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.
Kao SH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Jhang SW; Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.; Department of Veterinary Medicine, National Chung Hsing University, Taichung 40201, Taiwan.
Lin YC; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Chen CM; Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; College of Nursing and Health Sciences, Dayeh University, Changhua 51591, Taiwan.
Hsieh YH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Oct 28; Vol. 10 (11). Date of Electronic Publication: 2021 Oct 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Proteolysis*/drug effects
Signal Transduction*/drug effects
Glioblastoma/*pathology
Intercellular Signaling Peptides and Proteins/*metabolism
Janus Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Triterpenes/*pharmacology
Ubiquitin-Protein Ligases/*metabolism
Actins/metabolism ; Animals ; Apoptosis/drug effects ; Astrocytes/drug effects ; Astrocytes/pathology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Cytoskeleton/drug effects ; Cytoskeleton/metabolism ; Glioblastoma/metabolism ; Intercellular Signaling Peptides and Proteins/chemistry ; Molecular Docking Simulation ; Neoplasm Invasiveness ; Proteasome Endopeptidase Complex/metabolism ; Proto-Oncogene Proteins/chemistry ; Rats ; Receptor Protein-Tyrosine Kinases/chemistry ; Triterpenes/chemistry ; Tumor Stem Cell Assay ; Ubiquitin/metabolism ; Axl Receptor Tyrosine Kinase

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Skocz do pozycji: 6.

Tytuł:: All Good Things Must End: Termination of Receptor Tyrosine Kinase Signal.
Autorzy:: Margiotta A; Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 65691 Brno, Czech Republic.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 14; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 14.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Signal Transduction*
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Down-Regulation ; Humans ; Lysosomes/metabolism ; Mutation/genetics ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/genetics ; Ubiquitination

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Skocz do pozycji: 7.

Tytuł:: Pancreatic Adenocarcinoma Therapeutics Targeting RTK and TGF Beta Receptor.
Autorzy:: Yang HH; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
Liu JW; Everfront Biotech Inc., New Taipei City 221, Taiwan.
Lee JH; Everfront Biotech Inc., New Taipei City 221, Taiwan.
Harn HJ; Bioinnovation Center, Tzu Chi Foundation, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.; Department of Pathology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
Chiou TW; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 29; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antineoplastic Agents/*therapeutic use
Carcinoma, Pancreatic Ductal/*drug therapy
Pancreatic Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Receptors, Transforming Growth Factor beta/*antagonists & inhibitors
Signal Transduction/*drug effects
Cancer-Associated Fibroblasts/metabolism ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Pancreatic Neoplasms/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptors, Transforming Growth Factor beta/metabolism ; Treatment Outcome ; Tumor Microenvironment/drug effects

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Skocz do pozycji: 8.

Tytuł:: The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer.
Autorzy:: Purcaru OS; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Artene SA; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Barcan E; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Silosi CA; Department of Surgery, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Stanciu I; 'Victor Babeş' Clinical Hospital of Infectious Diseases and Pneumophtisiology, Craiova, Str. Calea Bucuresti, nr. 126, 200525 Craiova, Romania.
Danoiu S; Department of Physiopathology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.
Tudorache S; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy Craiova, 710204 Craiova, Romania.
Tataranu LG; Department of Neurosurgery, 'Bagdasar-Arseni' Emergency Hospital, Soseaua Berceni 12, 041915 Bucharest, Romania.
Dricu A; Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 710204 Craiova, Romania.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 May 02; Vol. 22 (9). Date of Electronic Publication: 2021 May 02.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
COVID-19/*metabolism
Neoplasms/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
SARS-CoV-2/*metabolism
Signal Transduction/*drug effects
Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/complications ; Drug Repositioning ; ErbB Receptors/metabolism ; Humans ; Middle East Respiratory Syndrome Coronavirus/metabolism ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/virology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/genetics

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Skocz do pozycji: 9.

Tytuł:: LncRNA-MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR-205-PTK7 pathway.
Autorzy:: Song Y; Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Guo NH; Institutional Office, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zheng JF; Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.; Pokaż więcej
Źródło:: Pathology international [Pathol Int] 2020 Oct; Vol. 70 (10), pp. 724-732. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Apoptosis/*genetics
Cell Adhesion Molecules/*metabolism
MicroRNAs/*metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
RNA, Long Noncoding/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Cell Adhesion Molecules/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; MicroRNAs/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; RNA, Long Noncoding/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Up-Regulation

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Skocz do pozycji: 10.

Tytuł:: Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways.
Autorzy:: Mannsåker TA; Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
Hoang T; Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
Aasen SN; Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
Bjørnstad OV; Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
Parajuli H; Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
Sundstrøm T; Department of Neurosurgery, Haukeland University Hospital, Haukelandsveien 22, 5021 Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Jonas Lies vei 87, 5009 Bergen, Norway.
Thorsen FA; Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.; Molecular Imaging Center, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 14; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 14.
Typ publikacji:: Journal Article
MeSH Terms:: Anilides/*pharmacology
Apoptosis/*drug effects
Cell Movement/*drug effects
Pyridines/*pharmacology
Signal Transduction/*drug effects
Apoptosis/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Melanoma/genetics ; Melanoma/metabolism ; Melanoma/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction/genetics

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Skocz do pozycji: 11.

Tytuł:: Lysophosphatidic Acid Upregulates Recepteur D'origine Nantais Expression and Cell Invasion via Egr-1, AP-1, and NF-κB Signaling in Bladder Carcinoma Cells.
Autorzy:: Khoi PN; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Li S; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Thuan UT; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Sah DK; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Kang TW; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Nguyen TT; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Lian S; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China.
Xia Y; Institute of Precision Medicine, Jining Medical University, Jining 272067, Shandong, China.
Jung YD; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Jan 01; Vol. 21 (1). Date of Electronic Publication: 2020 Jan 01.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Movement/*drug effects
Lysophospholipids/*pharmacology
Receptor Protein-Tyrosine Kinases/*metabolism
Signal Transduction/*drug effects
Up-Regulation/*drug effects
Urinary Bladder Neoplasms/*pathology
Cell Line, Tumor ; Cell Proliferation/drug effects ; Early Growth Response Protein 1/antagonists & inhibitors ; Early Growth Response Protein 1/genetics ; Early Growth Response Protein 1/metabolism ; Humans ; NF-kappa B/metabolism ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Receptors, Lysophosphatidic Acid/antagonists & inhibitors ; Receptors, Lysophosphatidic Acid/genetics ; Receptors, Lysophosphatidic Acid/metabolism ; Transcription Factor AP-1/antagonists & inhibitors ; Transcription Factor AP-1/metabolism ; Urinary Bladder Neoplasms/metabolism

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Skocz do pozycji: 12.

Tytuł:: RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells.
Autorzy:: Park JS; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju 61469, Korea. .
Choi HI; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju 61469, Korea. hoonin_.
Kim DH; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju 61469, Korea. .
Kim CS; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju 61469, Korea. .
Bae EH; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju 61469, Korea. .
Ma SK; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju 61469, Korea. .
Kim SW; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju 61469, Korea. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Nov 04; Vol. 20 (21). Date of Electronic Publication: 2019 Nov 04.
Typ publikacji:: Journal Article
MeSH Terms:: Epithelial-Mesenchymal Transition*
Signal Transduction*
Receptor Protein-Tyrosine Kinases/*metabolism
Smad Proteins/*metabolism
src-Family Kinases/*metabolism
Actins/genetics ; Actins/metabolism ; Animals ; Cell Line ; Epithelial Cells/metabolism ; Fibroblasts/metabolism ; Fibronectins/genetics ; Fibronectins/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Rats ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Receptors, Vascular Endothelial Growth Factor/genetics ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Smad Proteins/genetics ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; src-Family Kinases/genetics

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Skocz do pozycji: 13.

Tytuł:: Gas6/TAM Signaling Components as Novel Biomarkers of Liver Fibrosis.
Autorzy:: Smirne C; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.
Rigamonti C; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.
De Benedittis C; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.
Sainaghi PP; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.; Immunorheumatology Unit, CAAD (Center for Autoimmune and Allergic Diseases), 'Maggiore della Carità' Hospital, Novara, Italy.; IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Novara, Italy.
Bellan M; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.; Immunorheumatology Unit, CAAD (Center for Autoimmune and Allergic Diseases), 'Maggiore della Carità' Hospital, Novara, Italy.; IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Novara, Italy.
Burlone ME; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.
Castello LM; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.
Avanzi GC; Internal Medicine Division, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale (UPO), Novara, Italy.; IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Novara, Italy.; Pokaż więcej
Źródło:: Disease markers [Dis Markers] 2019 Sep 08; Vol. 2019, pp. 2304931. Date of Electronic Publication: 2019 Sep 08 (Print Publication: 2019).
Typ publikacji:: Journal Article; Review
MeSH Terms:: Intercellular Signaling Peptides and Proteins/*genetics
Liver/*metabolism
Liver Cirrhosis/*diagnosis
Proto-Oncogene Proteins/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
Signal Transduction/*genetics
c-Mer Tyrosine Kinase/*genetics
Biomarkers/blood ; Disease Progression ; Drugs, Investigational/pharmacology ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Gene Expression ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Intercellular Signaling Peptides and Proteins/blood ; Liver/drug effects ; Liver/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Molecular Targeted Therapy ; Proto-Oncogene Proteins/blood ; Receptor Protein-Tyrosine Kinases/blood ; Signal Transduction/drug effects ; c-Mer Tyrosine Kinase/blood ; Axl Receptor Tyrosine Kinase

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Skocz do pozycji: 14.

Tytuł:: Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer.
Autorzy:: Tanaka M; Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Siemann DW; Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 15; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Molecular Targeted Therapy*
Signal Transduction*
Intercellular Signaling Peptides and Proteins/*metabolism
Neoplasms/*drug therapy
Neoplasms/*metabolism
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Biological Products/therapeutic use ; Humans ; Axl Receptor Tyrosine Kinase

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Skocz do pozycji: 15.

Tytuł:: Reprogramming signal transduction through a designer receptor tyrosine kinase.
Autorzy:: Kongkrongtong T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Sumigama Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Nagamune T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Kawahara M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. .; Laboratory of Cell Vaccine, Center for Vaccine and Adjuvant Research (CVAR), National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2021 Jun 17; Vol. 4 (1), pp. 752. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Engineering/*methods
Receptor Protein-Tyrosine Kinases/*genetics
Receptor Protein-Tyrosine Kinases/*metabolism
Signal Transduction/*physiology
Synthetic Biology/*methods
Janus Kinases/genetics ; Janus Kinases/metabolism ; Protein Domains/physiology ; Proto-Oncogene Proteins c-kit/metabolism ; STAT5 Transcription Factor/metabolism ; Signal Transduction/genetics

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Skocz do pozycji: 16.

Tytuł:: Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling.
Autorzy:: Szybowska P; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway.
Kostas M; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway.
Wesche J; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway.
Haugsten EM; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway.
Wiedlocha A; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway.; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway.; Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland.; Pokaż więcej
Źródło:: Cells [Cells] 2021 May 28; Vol. 10 (6). Date of Electronic Publication: 2021 May 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Signal Transduction*
Fibroblast Growth Factors/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Animals ; Cell Line ; Humans

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Skocz do pozycji: 17.

Tytuł:: Optogenetic Approaches for the Spatiotemporal Control of Signal Transduction Pathways.
Autorzy:: Kramer MM; Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.; SGBM-Spemann Graduate School of Biology and Medicine, University of Freiburg, 79104 Freiburg, Germany.
Lataster L; Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.
Weber W; Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.; SGBM-Spemann Graduate School of Biology and Medicine, University of Freiburg, 79104 Freiburg, Germany.
Radziwill G; Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 May 18; Vol. 22 (10). Date of Electronic Publication: 2021 May 18.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Optogenetics/*methods
Signal Transduction/*genetics
Signal Transduction/*physiology
Animals ; Cell Communication/physiology ; Cell Differentiation/physiology ; Humans ; Integrins/metabolism ; Light ; Receptor Protein-Tyrosine Kinases/metabolism

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Skocz do pozycji: 18.

Tytuł:: Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions.
Autorzy:: Lu Y; The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Boswell M; The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Boswell W; The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Kneitz S; Physiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University Clinic Würzburg, Würzburg, Germany.
Hausmann M; Physiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University Clinic Würzburg, Würzburg, Germany.
Klotz B; Physiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University Clinic Würzburg, Würzburg, Germany.
Regneri J; Physiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University Clinic Würzburg, Würzburg, Germany.
Savage M; The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Amores A; Institute of Neuroscience, University of Oregon, Eugene, OR, USA.
Postlethwait J; Institute of Neuroscience, University of Oregon, Eugene, OR, USA.
Warren W; The Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Schartl M; Physiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University Clinic Würzburg, Würzburg, Germany.; Texas A&M Institute for Advanced Studies and Department of Biology, Texas A&M University, College Station, TX, USA.
Walter R; The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.; Pokaż więcej
Źródło:: Pigment cell & melanoma research [Pigment Cell Melanoma Res] 2018 Jul; Vol. 31 (4), pp. 496-508. Date of Electronic Publication: 2018 Jan 29.
Typ publikacji:: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Cyprinodontiformes*/genetics
Cyprinodontiformes*/metabolism
Fish Proteins*/genetics
Fish Proteins*/metabolism
Gene Expression Regulation, Neoplastic*
Melanoma*/genetics
Melanoma*/metabolism
Melanoma*/pathology
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Receptor Protein-Tyrosine Kinases*/genetics
Receptor Protein-Tyrosine Kinases*/metabolism
Signal Transduction*
Transcriptome*
Animals ; Female ; Humans ; Male ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology

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Skocz do pozycji: 19.

Tytuł:: Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas.
Autorzy:: Tsukita Y; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Fujino N; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan. .
Miyauchi E; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Saito R; Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Fujishima F; Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Itakura K; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Kyogoku Y; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Okutomo K; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Yamada M; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Okazaki T; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Sugiura H; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.
Inoue A; Department of Palliative Medicine, Tohoku University School of Medicine, Sendai, 980 8574, Japan.
Okada Y; Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980 0872, Japan.
Ichinose M; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2019 Feb 11; Vol. 18 (1), pp. 24. Date of Electronic Publication: 2019 Feb 11.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Proto-Oncogene Proteins/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
Signal Transduction/*genetics
Adenocarcinoma of Lung/immunology ; Adenocarcinoma of Lung/pathology ; Antineoplastic Agents/pharmacology ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; Benzocycloheptenes/pharmacology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cohort Studies ; Disease Progression ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Epithelial-Mesenchymal Transition/immunology ; ErbB Receptors/genetics ; ErbB Receptors/immunology ; Gene Expression Profiling ; Humans ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Oligonucleotide Array Sequence Analysis ; Prognosis ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins/immunology ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptor Protein-Tyrosine Kinases/immunology ; Receptors, CXCR6/genetics ; Receptors, CXCR6/immunology ; Signal Transduction/immunology ; Triazoles/pharmacology ; Axl Receptor Tyrosine Kinase

Raport

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Skocz do pozycji: 20.

Tytuł:: Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr phosphorylation.
Autorzy:: Gaviraghi M; Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
Rabellino A; Department of Experimental Medicine, University of Genoa, via De Toni 14, 16132, Genoa, Italy.; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4029, Australia.
Andolfo A; Protein Microsequencing Facility, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
Brand M; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria.
Brombin C; University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, via Olgettina 58, 20132, Milan, Italy.
Bagnato P; Department of Experimental Medicine, University of Genoa, via De Toni 14, 16132, Genoa, Italy.
De Feudis G; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.
Raimondi A; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.
Locatelli A; Department of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
Tosoni D; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20100, Milan, Italy.
Mazza D; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.
Gianni L; Department of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
Tonon G; Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.; Center for Translational Genomics and Bioinformatics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
Yarden Y; Weizmann Institute of Science, 76100, Rehovot, Israel.
Tacchetti C; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy. .; Vita-Salute San Raffaele University, via Olgettina 58, 20132, Milan, Italy. .
Daniele T; Department of Experimental Medicine, University of Genoa, via De Toni 14, 16132, Genoa, Italy. .; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Oct 09; Vol. 10 (1), pp. 16906. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytostatic Agents/*metabolism
Phosphorylation/*physiology
Receptor Protein-Tyrosine Kinases/*metabolism
Receptor, ErbB-2/*immunology
Signal Transduction/*physiology
Cell Line, Tumor ; Cell Proliferation/physiology ; Cell Transformation, Neoplastic/metabolism ; Dimerization ; Extracellular Signal-Regulated MAP Kinases ; Humans ; Proto-Oncogene Proteins c-akt/metabolism

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