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Wyszukujesz frazę ""Receptors, Androgen"" wg kryterium: Temat


Tytuł :
Inhibition of Androgen Receptor Signaling Promotes Prostate Cancer Cell Migration via Upregulation of Annexin A1 Expression.
Autorzy :
Yang W; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
Wang K; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, PR China.
Ma J; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
Hui K; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
Lv W; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
Ma Z; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, PR China.
Huan M; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
Luo L; Department of Urology, 521 Hospital of Norinco Group, Xi'an, PR China.
Wang X; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, PR China.
Li L; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, PR China. Electronic address: .
Chen Y; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, PR China. Electronic address: .
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Źródło :
Archives of medical research [Arch Med Res] 2021 Feb; Vol. 52 (2), pp. 174-181. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgen Antagonists/*therapeutic use
Annexin A1/*metabolism
Prostatic Neoplasms/*drug therapy
Prostatic Neoplasms/*metabolism
Receptors, Androgen/*metabolism
Androgen Antagonists/pharmacology ; Annexin A1/biosynthesis ; Annexin A1/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Humans ; Male ; Neoplasm Metastasis ; PC-3 Cells ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Androgen/biosynthesis ; Receptors, Androgen/genetics ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
The impact of graphene oxide on androgen receptor signalling in prostate cancer cells.
Autorzy :
Ženata O; Department of Cell Biology and Genetics, Faculty of Science, Palacky University in Olomouc, Slechtitelu 27, Olomouc, CZ-783 71, Czech Republic.
Panáček A; Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University in Olomouc, 17. Listopadu 12, 771 46, Olomouc, Czech Republic.
Kvítek L; Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University in Olomouc, 17. Listopadu 12, 771 46, Olomouc, Czech Republic.
Vrzal R; Department of Cell Biology and Genetics, Faculty of Science, Palacky University in Olomouc, Slechtitelu 27, Olomouc, CZ-783 71, Czech Republic. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Apr; Vol. 269, pp. 128759. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Prostatic Neoplasms*
Receptors, Androgen*/genetics
Androgens ; Cell Line, Tumor ; Dihydrotestosterone/pharmacology ; Graphite ; Humans ; Male
Czasopismo naukowe
Tytuł :
Testosterone stimulates cholesterol clearance from human macrophages by activating LXRα.
Autorzy :
Kilby EL; Department of Oncology and Metabolism, Medical School, The University of Sheffield, Sheffield, UK.
Kelly DM; Department of Oncology and Metabolism, Medical School, The University of Sheffield, Sheffield, UK; Biomolecular Research Centre, Sheffield Hallam University, Sheffield, UK. Electronic address: .
Jones TH; Department of Oncology and Metabolism, Medical School, The University of Sheffield, Sheffield, UK; Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK.
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119040. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cholesterol/*metabolism
Gene Expression Regulation, Leukemic/*drug effects
Leukemia, Monocytic, Acute/*metabolism
Liver X Receptors/*metabolism
Macrophages/*metabolism
Receptors, Androgen/*metabolism
Testosterone/*pharmacology
Androgens/pharmacology ; Humans ; Leukemia, Monocytic, Acute/drug therapy ; Leukemia, Monocytic, Acute/pathology ; Liver X Receptors/genetics ; Macrophages/drug effects ; Macrophages/pathology ; Receptors, Androgen/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma.
Autorzy :
Li Y; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Orahoske CM; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Geldenhuys WJ; Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, United States.
Bhattarai A; Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Sabbagh A; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Bobba V; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Salem FM; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Zhang W; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Shukla GC; Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Lathia JD; Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.; Department of Molecular Medicine, Lerner Research Institute, Cleveland Clinic, and Case Comprehensive Cancer Center, Cleveland, Ohio 44195, United States.
Wang B; Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, United States.
Su B; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Feb 11; Vol. 64 (3), pp. 1570-1583. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgen Antagonists/*pharmacology
Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
HSP27 Heat-Shock Proteins/*antagonists & inhibitors
Receptors, Androgen/*drug effects
Androgen Antagonists/toxicity ; Animals ; Brain Neoplasms/genetics ; Cell Line, Tumor ; Drug Delivery Systems ; Drug Design ; Gene Expression Regulation, Neoplastic/drug effects ; Glioblastoma/genetics ; Humans ; Mice ; Models, Molecular ; Molecular Docking Simulation ; Mutation ; Proteasome Endopeptidase Complex/drug effects ; Receptors, Androgen/genetics ; Small Molecule Libraries ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer.
Autorzy :
Hickey TE; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Selth LA; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.; Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.; Freemason's Foundation Centre for Men's Health, University of Adelaide, Adelaide, South Australia, Australia.
Chia KM; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Laven-Law G; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Milioli HH; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Roden D; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Jindal S; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Hui M; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Finlay-Schultz J; University of Colorado, Aurora, CO, USA.
Ebrahimie E; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Birrell SN; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Stelloo S; Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Oncode Institute, Radboud University Nijmegen, Nijmegen, the Netherlands.
Iggo R; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.; Institut Bergonié, University of Bordeaux, Bordeaux, France.
Alexandrou S; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Caldon CE; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Abdel-Fatah TM; University of Nottingham, Nottingham, UK.
Ellis IO; University of Nottingham, Nottingham, UK.
Zwart W; Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Palmieri C; Institute of Systems, Molecular and Integrative Biology, University of Liverpool & Clatterbridge Centre NHS Foundation Trust, Liverpool, UK.
Sartorius CA; University of Colorado, Aurora, CO, USA.
Swarbrick A; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Lim E; Garvan Institute of Medical Research & St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Carroll JS; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Tilley WD; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia. .; Freemason's Foundation Centre for Men's Health, University of Adelaide, Adelaide, South Australia, Australia. .
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Źródło :
Nature medicine [Nat Med] 2021 Feb; Vol. 27 (2), pp. 310-320. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgens/*pharmacology
Breast Neoplasms/*genetics
Estrogen Receptor alpha/*genetics
Receptors, Androgen/*genetics
Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/genetics ; Female ; Humans ; MCF-7 Cells ; Nuclear Receptor Coactivator 3/genetics ; Receptors, Androgen/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Androgen receptor agonists as breast cancer therapeutics.
Autorzy :
Caswell-Jin JL; Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA. .
Curtis C; Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. .; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. .
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Źródło :
Nature medicine [Nat Med] 2021 Feb; Vol. 27 (2), pp. 198-199.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Breast Neoplasms*/drug therapy
Receptors, Androgen*/genetics
Androgens ; Humans ; Receptors, Estrogen ; Signal Transduction
Czasopismo naukowe
Tytuł :
A Genetically Encoded Bioluminescence Intracellular Nanosensor for Androgen Receptor Activation Monitoring in 3D Cell Models.
Autorzy :
Calabretta MM; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.
Lopreside A; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.
Montali L; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.
Cevenini L; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.
Roda A; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Istituto Nazionale di Biostrutture e Biosistemi (INBB), 00136 Rome, Italy.
Michelini E; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.; Istituto Nazionale di Biostrutture e Biosistemi (INBB), 00136 Rome, Italy.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.
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Źródło :
Sensors (Basel, Switzerland) [Sensors (Basel)] 2021 Jan 29; Vol. 21 (3). Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens*
Luminescent Measurements*
Nanotechnology*
Receptors, Androgen*/genetics
Genes, Reporter ; HEK293 Cells ; Humans ; Luciferases/genetics
Czasopismo naukowe
Tytuł :
Tissue Expression of Androgen Receptor Splice Variant 7 at Radical Prostatectomy Predicts Risk of Progression in Untreated Nonmetastatic Prostate Cancer.
Autorzy :
Sciarra A; Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Maggi M; Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy, .
Salciccia S; Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Nicolai A; Department of Experimental Medicine, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Tortorella E; Department of Molecular Medicine, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Giantulli S; Department of Molecular Medicine, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Magliocca FM; Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Silvestri I; Department of Molecular Medicine, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Taglieri L; Department of Experimental Medicine, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Cattarino S; Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Scarpa S; Department of Experimental Medicine, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
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Źródło :
Oncology [Oncology] 2021; Vol. 99 (4), pp. 251-255. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Wiadomości
MeSH Terms :
Disease Progression*
Prostatectomy/*methods
Prostatic Neoplasms, Castration-Resistant/*metabolism
Prostatic Neoplasms, Castration-Resistant/*surgery
Receptors, Androgen/*metabolism
Aged ; Biomarkers, Tumor/metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Progression-Free Survival ; Prostatic Neoplasms, Castration-Resistant/mortality ; Prostatic Neoplasms, Castration-Resistant/pathology ; Protein Isoforms/metabolism ; Receptors, Androgen/genetics ; Retrospective Studies ; Risk
Periodyk
Tytuł :
Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications.
Autorzy :
Pisano C; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
Tucci M; Medical Oncology, Cardinal Massaia Hospital, Corso Dante Alighieri 202, 14100, Asti, Italy. Electronic address: .
Di Stefano RF; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
Turco F; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
Scagliotti GV; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
Di Maio M; Department of Oncology, University of Turin, at Division of Medical Oncology, Ordine Mauriziano Hospital, Via Magellano 1, 10028, Turin, Italy.
Buttigliero C; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
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Źródło :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2021 Jan; Vol. 157, pp. 103185. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Prostatic Neoplasms, Castration-Resistant*/drug therapy
Prostatic Neoplasms, Castration-Resistant*/genetics
Receptors, Androgen*/genetics
Androgen Antagonists ; Disease Progression ; Humans ; Male ; Phosphatidylinositol 3-Kinases
Czasopismo naukowe
Tytuł :
Cedrol suppresses glioblastoma progression by triggering DNA damage and blocking nuclear translocation of the androgen receptor.
Autorzy :
Chang KF; Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
Huang XF; Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
Chang JT; Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
Huang YC; Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
Weng JC; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, 33302, Taiwan, ROC.
Tsai NM; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan, ROC. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Dec 28; Vol. 495, pp. 180-190. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Polycyclic Sesquiterpenes/*administration & dosage
Receptors, Androgen/*metabolism
Temozolomide/*administration & dosage
Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA Damage ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Humans ; Mice ; Polycyclic Sesquiterpenes/pharmacology ; Protein Transport/drug effects ; Rats ; Reactive Oxygen Species/metabolism ; Receptors, Androgen/chemistry ; Temozolomide/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications.
Autorzy :
Aurilio G; Medical Oncology Division of Urogenital and Head and Neck Tumours, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Cimadamore A; Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, 60126 Ancona, Italy.
Mazzucchelli R; Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, 60126 Ancona, Italy.
Lopez-Beltran A; Department of Surgery, Cordoba University Medical School, 14071 Cordoba, Spain.
Verri E; Medical Oncology Division of Urogenital and Head and Neck Tumours, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Scarpelli M; Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, 60126 Ancona, Italy.
Massari F; Division of Oncology, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy.
Cheng L; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Santoni M; Oncology Unit, Macerata Hospital, 62100 Macerata, Italy.
Montironi R; Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, 60126 Ancona, Italy.
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Źródło :
Cells [Cells] 2020 Dec 10; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Neoplasm*
Prostatic Neoplasms/*metabolism
Receptors, Androgen/*metabolism
Androgen Receptor Antagonists/therapeutic use ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Prostatic Neoplasms/drug therapy ; Receptors, Androgen/chemistry ; Signal Transduction
Czasopismo naukowe
Tytuł :
Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer.
Autorzy :
Mout L; Department of Medical Oncology Erasmus MC-Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Moll JM; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Chen M; Division of Pharmaceutics College of Pharmacy, The Ohio State University, 217 Lloyd M. Parks Hall, 500 West 12th Avenue, Columbus, OH, 43210, USA.
de Morrée ES; Department of Medical Oncology Erasmus MC-Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
de Ridder CMA; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Gibson A; Division of Pharmaceutics College of Pharmacy, The Ohio State University, 217 Lloyd M. Parks Hall, 500 West 12th Avenue, Columbus, OH, 43210, USA.
Stuurman D; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Aghai A; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Erkens-Schulze S; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Mathijssen RHJ; Department of Medical Oncology Erasmus MC-Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Sparreboom A; Division of Pharmaceutics College of Pharmacy, The Ohio State University, 217 Lloyd M. Parks Hall, 500 West 12th Avenue, Columbus, OH, 43210, USA.
de Wit R; Department of Medical Oncology Erasmus MC-Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Lolkema MP; Department of Medical Oncology Erasmus MC-Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
van Weerden WM; Department of Urology Erasmus University MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. .
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Źródło :
British journal of cancer [Br J Cancer] 2020 Dec; Vol. 123 (12), pp. 1715-1719. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgen Antagonists/*therapeutic use
Antineoplastic Agents/*therapeutic use
Docetaxel/*therapeutic use
Drug Resistance, Neoplasm/*physiology
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Receptors, Androgen/*metabolism
Testosterone/*pharmacology
Acetylation ; Androgen Antagonists/pharmacokinetics ; Androgen Receptor Antagonists/therapeutic use ; Animals ; Antineoplastic Agents/pharmacokinetics ; Cell Death ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Survival ; Disease Progression ; Docetaxel/pharmacokinetics ; Drug Interactions ; Humans ; In Situ Nick-End Labeling ; Male ; Mice ; Mice, Nude ; Neoplasm Proteins/metabolism ; Neoplasm Transplantation ; Prostate-Specific Antigen/biosynthesis ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Prostatic Neoplasms, Castration-Resistant/pathology ; Receptors, Androgen/drug effects ; Signal Transduction/drug effects ; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism ; Testosterone/administration & dosage ; Testosterone/antagonists & inhibitors ; Testosterone/metabolism ; Tubulin/drug effects ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Genetic Variation in the Androgen Receptor Modifies the Association Between Testosterone and Vitality in Middle-Aged Men.
Autorzy :
Panizzon MS; Department of Psychiatry, University of California, San Diego, La Jolla, CA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA. Electronic address: .
Bree K; Department of Urology, University of California, San Diego, La Jolla, CA.
Hsieh TC; Department of Urology, University of California, San Diego, La Jolla, CA.
Hauger R; Department of Psychiatry, University of California, San Diego, La Jolla, CA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA.
Xian H; Department of Biostatistics, College of Public Health and Social Justice, St. Louis University, St. Louis, MO; Research Service, St. Louis veterans Affairs Medical Center, St. Louis, MO.
Jacobson K; Department of Psychiatry, University of Chicago, Chicago, IL.
Lyons MJ; Department of Psychological and Brain Sciences, Boston University, Boston, MA.
Franz CE; Department of Psychiatry, University of California, San Diego, La Jolla, CA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA.
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Źródło :
The journal of sexual medicine [J Sex Med] 2020 Dec; Vol. 17 (12), pp. 2351-2361. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Receptors, Androgen*/genetics
Testosterone*
Aging ; Cross-Sectional Studies ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Trinucleotide Repeats
Czasopismo naukowe
Tytuł :
Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer.
Autorzy :
He Y; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Hwang DJ; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Ponnusamy S; Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Thiyagarajan T; Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Mohler ML; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Narayanan R; Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Miller DD; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12642-12665. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgen Receptor Antagonists/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Pyrazoles/*chemistry
Receptors, Androgen/*metabolism
Androgen Receptor Antagonists/chemistry ; Androgen Receptor Antagonists/metabolism ; Androgen Receptor Antagonists/therapeutic use ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Design ; Half-Life ; Humans ; Male ; Mice ; Microsomes, Liver/metabolism ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Phenylthiohydantoin/therapeutic use ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptors, Androgen/chemistry ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance.
Autorzy :
Vellky JE; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.; Cancer Biology Graduate Program, University of Wisconsin-Madison, Wisconsin Institute for Medical Research, Madison, WI 53705.; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.
McSweeney ST; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.
Ricke EA; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.; George M. O'Brien Research Center of Excellence, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.
Ricke WA; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705; .; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.; George M. O'Brien Research Center of Excellence, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28092-28101. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DEAD-box RNA Helicases/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Prostatic Neoplasms, Castration-Resistant/*genetics
Prostatic Neoplasms, Castration-Resistant/*metabolism
Receptors, Androgen/*genetics
Animals ; Cell Line, Tumor ; DEAD-box RNA Helicases/metabolism ; Humans ; Male ; Mice ; Mice, Nude ; Prostate/chemistry ; Prostate/pathology ; Prostatic Neoplasms, Castration-Resistant/chemistry ; Prostatic Neoplasms, Castration-Resistant/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Androgen/metabolism
Czasopismo naukowe
Tytuł :
Comparison of Machine Learning Models for the Androgen Receptor.
Autorzy :
Zorn KM; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Foil DH; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Lane TR; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Hillwalker W; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Feifarek DJ; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Jones F; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Klaren WD; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Brinkman AM; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Ekins S; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2020 Nov 03; Vol. 54 (21), pp. 13690-13700. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Machine Learning*
Receptors, Androgen*
Androgens ; Bayes Theorem ; Prospective Studies ; United States
Czasopismo naukowe
Tytuł :
Androgen sensitivity gateway to COVID-19 disease severity.
Autorzy :
Wambier CG; Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Goren A; Applied Biology, Inc., Irvine, California, USA.
Vaño-Galván S; Trichology Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Ramos PM; Department of Dermatology and Radiotherapy, São Paulo State University - UNESP, São Paulo, Brazil.
Ossimetha A; Brown University, Providence, Rhode Island, USA.
Nau G; Division of Infectious Diseases, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Herrera S; Trichology Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.
McCoy J; Applied Biology, Inc., Irvine, California, USA.
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Źródło :
Drug development research [Drug Dev Res] 2020 Nov; Vol. 81 (7), pp. 771-776. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Alopecia/*etiology
COVID-19/*complications
Receptors, Androgen/*genetics
Alopecia/genetics ; Alopecia/metabolism ; COVID-19/genetics ; COVID-19/metabolism ; Humans ; Male ; Models, Theoretical ; Pandemics ; Receptors, Androgen/metabolism ; SARS-CoV-2/physiology ; Serine Endopeptidases/metabolism ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors.
Autorzy :
Zhu Y; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Dalrymple SL; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Coleman I; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Zheng SL; Program for Personalized Cancer Care, North Shore University Health System, Evanston, IL, USA.
Xu J; Program for Personalized Cancer Care, North Shore University Health System, Evanston, IL, USA.
Hooper JE; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Antonarakis ES; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
De Marzo AM; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Meeker AK; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Nelson PS; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Medicine and Urology, University of Washington, Seattle, WA, 98195, USA.
Isaacs WB; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Denmeade SR; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Luo J; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Brennen WN; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Isaacs JT; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. .; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. .
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Źródło :
Oncogene [Oncogene] 2020 Nov; Vol. 39 (45), pp. 6935-6949. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Androgen Antagonists/*pharmacology
Drug Resistance, Neoplasm/*genetics
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Receptors, Androgen/*genetics
Abiraterone Acetate/pharmacology ; Abiraterone Acetate/therapeutic use ; Aged ; Androgen Antagonists/therapeutic use ; Animals ; Biopsy ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Gene Knockout Techniques ; Humans ; Male ; Mice ; Middle Aged ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Phenylthiohydantoin/therapeutic use ; Prostate/pathology ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Splicing ; RNA-Seq ; Receptors, Androgen/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
PIK3CG Is a Potential Therapeutic Target in Androgen Receptor-Indifferent Metastatic Prostate Cancer.
Autorzy :
Chung WC; Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, Mississippi.
Zhou X; Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Atfi A; Department of Pathology, Virginia Commonwealth University, Richmond, Virginia.
Xu K; Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, Mississippi; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Nov; Vol. 190 (11), pp. 2194-2202. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Class Ib Phosphatidylinositol 3-Kinase/*metabolism
Neoplasm Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Receptors, Androgen/*metabolism
Animals ; Class Ib Phosphatidylinositol 3-Kinase/genetics ; Male ; Mice ; Mice, Transgenic ; Neoplasm Metastasis ; Neoplasm Proteins/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Receptors, Androgen/genetics
Czasopismo naukowe
Tytuł :
DNA methyltransferase-1 inactivation of androgen receptor axis triggers homocysteine induced cardiac fibroblast autophagy in diabetic cardiac fibrosis.
Autorzy :
Tao H; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 210009, PR China; Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601, PR China.
Shi P; Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601, PR China.
Xuan HY; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, PR China. Electronic address: .
Ding XS; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 210009, PR China. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Oct 15; Vol. 692, pp. 108521. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA (Cytosine-5-)-Methyltransferase 1*/antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferase 1*/genetics
DNA (Cytosine-5-)-Methyltransferase 1*/metabolism
Receptors, Androgen*/genetics
Receptors, Androgen*/metabolism
Diabetes Mellitus, Experimental/*metabolism
Diabetic Cardiomyopathies/*metabolism
Enzyme Inhibitors/*pharmacology
Fibroblasts/*metabolism
Homocysteine/*metabolism
Myocardium/*metabolism
Animals ; Collagen/biosynthesis ; Collagen/genetics ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/pathology ; Diabetic Cardiomyopathies/genetics ; Diabetic Cardiomyopathies/pathology ; Fibroblasts/pathology ; Fibrosis ; Gene Expression Regulation/drug effects ; Gene Knockout Techniques ; Homocysteine/genetics ; Male ; Myocardium/pathology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe

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