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Wyszukujesz frazę ""Receptors, Antigen, T-Cell, alpha-beta"" wg kryterium: Temat


Tytuł :
Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling.
Autorzy :
Zareie P; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Szeto C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Farenc C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Gunasinghe SD; European Molecular Biology Laboratory (EMBL) Australia Node in Single Molecule Science and the ARC Centre of Excellence in Advanced Molecular Imaging, School of Medical Sciences, University of New South Wales, New South Wales, Australia.
Kolawole EM; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Nguyen A; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Blyth C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Sng XYX; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Li J; Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jones CM; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Fulcher AJ; Monash Micro Imaging, Monash University, Clayton, Victoria, Australia.
Jacobs JR; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Wei Q; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Wojciech L; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Petersen J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Gascoigne NRJ; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Evavold BD; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Gaus K; European Molecular Biology Laboratory (EMBL) Australia Node in Single Molecule Science and the ARC Centre of Excellence in Advanced Molecular Imaging, School of Medical Sciences, University of New South Wales, New South Wales, Australia.
Gras S; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
La Gruta NL; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Histocompatibility Antigen H-2D/*metabolism
Nucleocapsid Proteins/*metabolism
Orthomyxoviridae Infections/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Animals ; CD3 Complex/metabolism ; CD8 Antigens/immunology ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Epitopes, T-Lymphocyte ; Female ; Histocompatibility Antigen H-2D/chemistry ; Histocompatibility Antigen H-2D/immunology ; Influenza A virus ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Major Histocompatibility Complex ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Nucleocapsid Proteins/chemistry ; Nucleocapsid Proteins/immunology ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Protein Binding ; Protein Conformation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Electrostatic Complementarity of T-Cell Receptor-Alpha CDR3 Domains and Mutant Amino Acids Is Associated with Better Survival Rates for Sarcomas.
Autorzy :
Yeagley M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Chobrutskiy BI; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Medikonda N; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Patel DN; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Falasiri S; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Callahan BM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Huda T; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
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Źródło :
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2021 Apr; Vol. 38 (3), pp. 251-264. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Complementarity Determining Regions/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Sarcoma/*genetics
Amino Acids/genetics ; Child ; Complementarity Determining Regions/chemistry ; Exome ; Humans ; Kaplan-Meier Estimate ; Mutation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Sarcoma/epidemiology ; Static Electricity ; Survival Rate
Czasopismo naukowe
Tytuł :
Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner.
Autorzy :
Smith AR; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556.
Alonso JA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556.
Ayres CM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556.
Singh NK; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556.
Hellman LM; Department of Physical and Life Sciences, Nevada State College, Henderson, NV 89002.
Baker BM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556; .; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HLA-A2 Antigen/*chemistry
Peptides/*chemistry
Receptors, Antigen, T-Cell, alpha-beta/*chemistry
Th2 Cells/*immunology
Allosteric Regulation ; Binding Sites ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HLA-A2 Antigen/genetics ; HLA-A2 Antigen/immunology ; Humans ; Jurkat Cells ; Kinetics ; Models, Molecular ; Peptides/genetics ; Peptides/immunology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Engineering ; Protein Interaction Domains and Motifs ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Th2 Cells/cytology ; Thermodynamics
Czasopismo naukowe
Tytuł :
Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences.
Autorzy :
Yohannes DA; Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Kaukinen K; Department of Internal Medicine, Faculty of Medicine and Health Technology, Tampere University Hospital, Tampere University, Tampere, Finland.
Kurppa K; Department of Pediatrics, Tampere University Hospital and Center for Child Health Research, Tampere University, Tampere, Finland.
Saavalainen P; Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Greco D; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. .; BioMediTech Institute, Tampere University, Tampere, Finland. .; Institute of Biotechnology, University of Helsinki, Helsinki, Finland. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Mar 25; Vol. 22 (1), pp. 159. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Antigen, T-Cell*
Receptors, Antigen, T-Cell, alpha-beta*/genetics
Cluster Analysis ; Humans ; T-Lymphocytes
Czasopismo naukowe
Tytuł :
CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs.
Autorzy :
Johnson DK; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Magoffin W; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Myers SJ; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Finnell JG; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, United States.
Hancock JC; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Orton TS; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Persaud SP; Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, United States.
Christensen KA; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, United States.
Weber KS; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jan 19; Vol. 11, pp. 561889. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocyte Activation*
Models, Immunological*
CD4 Antigens/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Receptors, Chimeric Antigen/*immunology
Signal Transduction/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
Animals ; Antigens, Neoplasm/immunology ; Histocompatibility Antigens Class II/immunology ; Hybridomas ; Immunotherapy, Adoptive/methods ; Interleukin-2/metabolism ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Chimeric Antigen/genetics ; Transduction, Genetic ; Yeasts/immunology
Czasopismo naukowe
Tytuł :
Atypical TRAV1-2 T cell receptor recognition of the antigen-presenting molecule MR1.
Autorzy :
Awad W; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Meermeier EW; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Sandoval-Romero ML; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Le Nours J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Worley AH; Veterans Affairs Portland Health Care Center, Portland, Oregon, USA.
Null MD; Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA.
Liu L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland, Australia.
McCluskey J; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Fairlie DP; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland, Australia.
Lewinsohn DM; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA.; Veterans Affairs Portland Health Care Center, Portland, Oregon, USA.; Department of Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia .; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, United Kingdom.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 16; Vol. 295 (42), pp. 14445-14457. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Histocompatibility Antigens Class I/*metabolism
Minor Histocompatibility Antigens/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Amino Acid Sequence ; Antigen Presentation ; Binding Sites ; Crystallography, X-Ray ; Histocompatibility Antigens Class I/chemistry ; Histocompatibility Antigens Class I/genetics ; Humans ; Minor Histocompatibility Antigens/chemistry ; Minor Histocompatibility Antigens/genetics ; Molecular Docking Simulation ; Protein Refolding ; Protein Structure, Tertiary ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Ribitol/analogs & derivatives ; Ribitol/chemistry ; Ribitol/metabolism ; Surface Plasmon Resonance ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism ; Uracil/analogs & derivatives ; Uracil/chemistry ; Uracil/metabolism
Czasopismo naukowe
Tytuł :
Resolving the Instructions for αβ T Cell Development.
Autorzy :
Cleveland SB; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Huseby ES; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2020 Dec 15; Vol. 53 (6), pp. 1126-1128.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Receptors, Antigen, T-Cell, alpha-beta*/genetics
Receptors, Antigen, T-Cell, gamma-delta*/genetics
Animals ; Cell Differentiation ; Epigenomics ; Humans ; Mice ; T-Lymphocyte Subsets ; Transcriptome
Czasopismo naukowe
Tytuł :
Population variability in the generation and selection of T-cell repertoires.
Autorzy :
Sethna Z; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.
Isacchini G; Laboratoire de physique de l'École Normale Supérieure, PSL University, CNRS, Sorbonne Université, Université de Paris 24 rue Lhomond, Paris, France.; Max Planck Institute for Dynamics and Self-organization, Am Faßberg 17, Göttingen, Germany.
Dupic T; Laboratoire de physique de l'École Normale Supérieure, PSL University, CNRS, Sorbonne Université, Université de Paris 24 rue Lhomond, Paris, France.
Mora T; Laboratoire de physique de l'École Normale Supérieure, PSL University, CNRS, Sorbonne Université, Université de Paris 24 rue Lhomond, Paris, France.
Walczak AM; Laboratoire de physique de l'École Normale Supérieure, PSL University, CNRS, Sorbonne Université, Université de Paris 24 rue Lhomond, Paris, France.
Elhanati Y; Computational Oncology, Department of Epidemiology and Biostatistics, and Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Dec 09; Vol. 16 (12), pp. e1008394. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
T-Lymphocytes/*metabolism
Adaptive Immunity ; Humans ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; T-Lymphocytes/immunology ; V(D)J Recombination
Czasopismo naukowe
Tytuł :
Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs).
Autorzy :
He Y; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Agnihotri P; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Rangarajan S; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Chen Y; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Kerzic MC; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Ma B; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Mariuzza RA; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. Electronic address: .
Orban J; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2020 Dec 04; Vol. 432 (24), pp. 166697. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histocompatibility Antigens Class I/*immunology
Histocompatibility Antigens Class II/*immunology
Peptides/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Allosteric Site/genetics ; Binding Sites/genetics ; Conserved Sequence/genetics ; HLA-DR4 Antigen/genetics ; HLA-DR4 Antigen/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class II/genetics ; Humans ; Molecular Dynamics Simulation ; Peptides/genetics ; Protein Binding/genetics ; Protein Conformation ; Receptor-CD3 Complex, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Analysis of the Chinese Alligator TCRα/δ Loci Reveals the Evolutionary Pattern of Atypical TCRδ/TCRμ in Tetrapods.
Autorzy :
Wang X; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Plant Protection, China Agricultural University, Beijing 100193, People's Republic of China.
Huang J; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Wang P; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Wang R; Administration Bureau of Alligator sinensis National Nature Reserve Protection, Anhui 242000, People's Republic of China.
Wang C; Administration Bureau of Alligator sinensis National Nature Reserve Protection, Anhui 242000, People's Republic of China.
Yu D; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Ke C; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Huang T; Henan Engineering Laboratory for Mammary Bioreactor, School of Life Sciences, Henan University, Kaifeng 475004, Henan, People's Republic of China; and.
Song Y; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Bai J; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Li K; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Ren L; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China.
Miller RD; Department of Biology, Center for Evolutionary and Theoretical Immunology, University of New Mexico, Albuquerque, NM 87131.
Han H; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China; .
Zhou X; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Plant Protection, China Agricultural University, Beijing 100193, People's Republic of China; .
Zhao Y; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People's Republic of China; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Aug 01; Vol. 205 (3), pp. 637-647. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alligators and Crocodiles*/genetics
Alligators and Crocodiles*/immunology
Evolution, Molecular*
Genetic Loci*
Receptors, Antigen, T-Cell, alpha-beta*/genetics
Receptors, Antigen, T-Cell, alpha-beta*/immunology
Reptilian Proteins*/genetics
Reptilian Proteins*/immunology
Animals
Czasopismo naukowe
Tytuł :
T-Cell Receptor CDR3 Loop Conformations in Solution Shift the Relative Vα-Vβ Domain Distributions.
Autorzy :
Fernández-Quintero ML; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Pomarici ND; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Loeffler JR; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Seidler CA; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Liedl KR; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Jul 08; Vol. 11, pp. 1440. Date of Electronic Publication: 2020 Jul 08 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complementarity Determining Regions/*chemistry
Receptors, Antigen, T-Cell, alpha-beta/*chemistry
Adaptive Immunity ; Animals ; Antigens/metabolism ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/metabolism ; Crystallography, X-Ray ; Histocompatibility Antigens/metabolism ; Humans ; Molecular Dynamics Simulation ; Peptides/metabolism ; Protein Binding ; Protein Conformation ; Protein Domains/genetics ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Structure-Activity Relationship ; T-Cell Antigen Receptor Specificity
Czasopismo naukowe
Tytuł :
Replacement of TCR Dβ With Immunoglobulin D H DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development.
Autorzy :
Levinson M; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Khass M; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Division of Genetic Engineering and Biotechnology, National Research Center, Cairo, Egypt.
Burrows PD; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Schroeder HW Jr; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Sep 29; Vol. 11, pp. 573413. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Complementarity Determining Regions*
Genes, Immunoglobulin Heavy Chain*
Genes, T-Cell Receptor beta*
Immunoglobulin Heavy Chains/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
T-Lymphocytes/*metabolism
Thymocytes/*metabolism
Animals ; Immunization ; Immunodominant Epitopes ; Immunoglobulin Heavy Chains/genetics ; Lymphocyte Activation ; Mice, Inbred C57BL ; Mice, Knockout ; Ovalbumin/administration & dosage ; Ovalbumin/immunology ; Phenotype ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes/immunology ; Thymocytes/immunology ; Tyrosine
Czasopismo naukowe
Tytuł :
RSSs set the odds for exclusion.
Autorzy :
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 Sep 07; Vol. 217 (9).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Protein Sorting Signals*
Receptors, Antigen, T-Cell, alpha-beta*/genetics
Alleles ; Recombination, Genetic
Czasopismo naukowe
Tytuł :
Peptide cargo tunes a network of correlated motions in human leucocyte antigens.
Autorzy :
Hopkins JR; Division of Infection and Immunity, School of Medicine, Cardiff University, UK.
Crean RM; Department of Biology and Biochemistry, University of Bath, UK.; Doctoral Training Centre in Sustainable Chemical Technologies, University of Bath, UK.
Catici DAM; Department of Biology and Biochemistry, University of Bath, UK.
Sewell AK; Division of Infection and Immunity, School of Medicine, Cardiff University, UK.
Arcus VL; School of Science, Faculty of Science and Engineering, University of Waikato, Hamilton, New Zealand.
Van der Kamp MW; School of Biochemistry, University of Bristol, UK.
Cole DK; Division of Infection and Immunity, School of Medicine, Cardiff University, UK.
Pudney CR; Department of Biology and Biochemistry, University of Bath, UK.; Centre for Therapeutic Innovation, University of Bath, UK.
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Źródło :
The FEBS journal [FEBS J] 2020 Sep; Vol. 287 (17), pp. 3777-3793. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HLA-A2 Antigen/*chemistry
Peptides/*chemistry
Receptors, Antigen, T-Cell, alpha-beta/*chemistry
Allosteric Regulation ; Allosteric Site ; Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; HLA-A2 Antigen/metabolism ; Humans ; Insulin/chemistry ; Models, Molecular ; Molecular Dynamics Simulation ; Motion ; Peptides/metabolism ; Pressure ; Protein Binding ; Protein Conformation ; Protein Precursors/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Temperature ; beta 2-Microglobulin/chemistry ; beta 2-Microglobulin/metabolism
Czasopismo naukowe
Tytuł :
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART.
Autorzy :
Gantner P; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
Pagliuzza A; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Pardons M; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
Ramgopal M; Midway Immunology & Research Center, Fort Pierce, FL, USA.
Routy JP; Division of Hematology & Chronic Viral Illness Service, McGill University Heath Centre, Montreal, QC, Canada.
Fromentin R; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Chomont N; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada. .; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 14; Vol. 11 (1), pp. 4089. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Retroviral Agents/*therapeutic use
HIV Infections/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Adult ; Cells, Cultured ; Female ; Flow Cytometry ; HIV Infections/drug therapy ; HIV-1/drug effects ; HIV-1/genetics ; HIV-1/pathogenicity ; Humans ; Male ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Viral Load ; Virus Replication/drug effects ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
Autorzy :
Coles CH; Immunocore Ltd., Abingdon, United Kingdom.
McMurran C; Immunocore Ltd., Abingdon, United Kingdom.
Lloyd A; Immunocore Ltd., Abingdon, United Kingdom.
Hock M; Immunocore Ltd., Abingdon, United Kingdom.
Hibbert L; Immunocore Ltd., Abingdon, United Kingdom.
Raman MCC; Immunocore Ltd., Abingdon, United Kingdom.
Hayes C; Immunocore Ltd., Abingdon, United Kingdom.
Lupardus P; Genentech, Inc., South San Francisco, California, USA.
Cole DK; Immunocore Ltd., Abingdon, United Kingdom .; Cardiff University School of Medicine, Cardiff, United Kingdom.
Harper S; Immunocore Ltd., Abingdon, United Kingdom .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Aug 14; Vol. 295 (33), pp. 11486-11494. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Neoplasm/*immunology
HLA-A2 Antigen/*immunology
Neoplasm Proteins/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Antigens, Neoplasm/chemistry ; Crystallography, X-Ray ; HLA-A2 Antigen/chemistry ; Humans ; Models, Molecular ; Neoplasm Proteins/chemistry ; Peptides/chemistry ; Peptides/immunology ; Protein Conformation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry
Czasopismo naukowe
Tytuł :
Profiling the pattern of human TRB/IGH-CDR3 repertoire in liver transplantation patients via high-throughput sequencing analysis.
Autorzy :
Han FF; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Fan H; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Ren LL; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wang HG; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wang C; Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Ma X; Department of Genetics, National Research Institute for Family Planning, Beijing, China.; Graduate School of Peking, Union Medical College, Beijing, China.
Liu LH; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
He Q; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Guo CL; Department of Genetics, National Research Institute for Family Planning, Beijing, China.; Graduate School of Peking, Union Medical College, Beijing, China.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Aug; Vol. 92 (2), pp. e12912. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Liver Transplantation*
Complementarity Determining Regions/*immunology
Graft Rejection/*immunology
Immunoglobulin Heavy Chains/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Adult ; Complementarity Determining Regions/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Immunoglobulin Heavy Chains/genetics ; Male ; Middle Aged ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Czasopismo naukowe
Tytuł :
Dissecting efficiency of a 5' rapid amplification of cDNA ends (5'-RACE) approach for profiling T-cell receptor beta repertoire.
Autorzy :
Lin YH; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Hung SJ; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Chen YL; Molecular Diagnostic Laboratory, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan.
Lin CH; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Kung TF; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Yeh YC; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Tseng JT; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Liu T; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
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Źródło :
PloS one [PLoS One] 2020 Jul 23; Vol. 15 (7), pp. e0236366. Date of Electronic Publication: 2020 Jul 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Sequence/*genetics
DNA/*genetics
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Base Sequence ; DNA Fragmentation ; DNA, Complementary/genetics ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/immunology ; Humans ; Receptors, Antigen, T-Cell, alpha-beta/immunology
Czasopismo naukowe
Tytuł :
High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires.
Autorzy :
Soto C; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Bombardi RG; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kozhevnikov M; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sinkovits RS; San Diego Supercomputer Center, University of California, San Diego, San Diego, CA 92093, USA.
Chen EC; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
Branchizio A; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kose N; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Day SB; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Pilkinton M; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Gujral M; San Diego Supercomputer Center, University of California, San Diego, San Diego, CA 92093, USA.
Mallal S; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Crowe JE Jr; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Jul 14; Vol. 32 (2), pp. 107882.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Clone Cells/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Adult ; Amino Acid Sequence ; DNA/genetics ; Female ; Genome, Human ; Humans ; Lymphocyte Subsets/immunology ; Male ; Middle Aged ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Young Adult
Czasopismo naukowe
Tytuł :
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC mice.
Autorzy :
Szeponik L; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. .
Akeus P; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Rodin W; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Raghavan S; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Quiding-Järbrink M; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Jul; Vol. 69 (7), pp. 1279-1292. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Adenomatous Polyposis Coli Protein/*physiology
CD8 Antigens/*immunology
CD8-Positive T-Lymphocytes/*immunology
Intestinal Neoplasms/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Humans ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Lymphocyte Activation ; Lymphocyte Depletion ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/metabolism
Czasopismo naukowe

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