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Tytuł :
Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population.
Autorzy :
Walsh S; Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Dr. Aiguader, 88, 08003, Barcelona, Catalonia, Spain.
Izquierdo-Serra M; Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain.
Acosta S; Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Dr. Aiguader, 88, 08003, Barcelona, Catalonia, Spain.
Edo A; Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain.
Lloret M; Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain.
Moret R; Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Dr. Aiguader, 88, 08003, Barcelona, Catalonia, Spain.
Bosch E; Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Dr. Aiguader, 88, 08003, Barcelona, Catalonia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 43206, Reus, Spain.
Oliva B; Structural Bioinformatics Lab, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain.
Bertranpetit J; Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Dr. Aiguader, 88, 08003, Barcelona, Catalonia, Spain. .
Fernández-Fernández JM; Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 02; Vol. 10 (1), pp. 20999. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels/*genetics
Loss of Function Mutation/*genetics
Receptors, Cell Surface/*genetics
Adolescent ; Adult ; Amino Acid Substitution/genetics ; Calcium Channels/physiology ; Ethiopia/epidemiology ; Female ; Fluorescent Antibody Technique ; Humans ; Male ; Middle Aged ; Patch-Clamp Techniques ; Polymerase Chain Reaction ; Receptors, Cell Surface/physiology ; Selection, Genetic/genetics ; Taste/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
How do moth and butterfly taste?-Molecular basis of gustatory receptors in Lepidoptera.
Autorzy :
Xu W; Agricultural Sciences, College of Science, Health, Engineering and Education, Murdoch University, WA, Australia.
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Źródło :
Insect science [Insect Sci] 2020 Dec; Vol. 27 (6), pp. 1148-1157. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Butterflies/*physiology
Insect Proteins/*genetics
Moths/*physiology
Receptors, Cell Surface/*genetics
Taste Perception/*genetics
Animals ; Butterflies/genetics ; Butterflies/growth & development ; Cell Biology ; Clustered Regularly Interspaced Short Palindromic Repeats ; Cytological Techniques/methods ; High-Throughput Nucleotide Sequencing/methods ; Insect Proteins/metabolism ; Larva/genetics ; Larva/growth & development ; Larva/physiology ; Moths/genetics ; Moths/growth & development ; RNA Interference ; Receptors, Cell Surface/metabolism
Czasopismo naukowe
Tytuł :
The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans.
Autorzy :
Naidoo KK; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Shangase ZB; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Rashid T; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Ngubane A; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Ismail N; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Ndung'u T; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, United States of America.; Africa Health Research Institute, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.; Division of Infection and Immunity, University College London, London, United Kingdom.
Thobakgale CF; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Faculty of Health Sciences, Centre for HIV and STIs, National Institute for Communicable Diseases, University of the Witwatersrand, Johannesburg, South Africa.
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Źródło :
PloS one [PLoS One] 2020 Nov 19; Vol. 15 (11), pp. e0242448. Date of Electronic Publication: 2020 Nov 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
African Continental Ancestry Group/*genetics
Killer Cells, Natural/*immunology
Receptors, Cell Surface/*deficiency
T-Lymphocytes, Cytotoxic/*immunology
Anti-HIV Agents/blood ; Anti-HIV Agents/therapeutic use ; Cell Division ; Cell Survival ; Cytokines/blood ; Duffy Blood-Group System/genetics ; Female ; Genotype ; HIV Infections/blood ; HIV Infections/drug therapy ; HIV Infections/genetics ; HIV Infections/immunology ; HIV-1 ; Humans ; Immunophenotyping ; Lymphocyte Count ; Male ; Receptors, Cell Surface/genetics ; South Africa ; Viral Load ; Young Adult
Czasopismo naukowe
Tytuł :
Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex.
Autorzy :
Bar-El ML; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 6997801, Israel.
Vaňková P; Institute of Microbiology of the Czech Academy of Sciences, Division BioCeV, Prumyslova, 595, 252 50, Vestec, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030/8, 128 43, Prague 2, Czech Republic.
Yeheskel A; Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv, 6997801, Israel.
Simhaev L; Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv, 6997801, Israel.
Engel H; Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv, 6997801, Israel.
Man P; Institute of Microbiology of the Czech Academy of Sciences, Division BioCeV, Prumyslova, 595, 252 50, Vestec, Czech Republic.
Haitin Y; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 6997801, Israel. .; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 6997801, Israel. .
Giladi M; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 6997801, Israel. .; Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 19; Vol. 11 (1), pp. 5273. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkyl and Aryl Transferases/*chemistry
Receptors, Cell Surface/*chemistry
Retinitis Pigmentosa/*genetics
Transferases/*chemistry
Transferases/*genetics
Alkyl and Aryl Transferases/genetics ; Alkyl and Aryl Transferases/metabolism ; Amino Acid Motifs ; Catalytic Domain ; Dimerization ; Humans ; Mutation ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Retinitis Pigmentosa/enzymology ; Transferases/metabolism
Czasopismo naukowe
Tytuł :
Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology.
Autorzy :
Gómez-Rial J; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.; Laboratorio de Inmunologìa, Servicio de Análisis Clìnicos, Hospital Clìnico Universitario Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.
Currás-Tuala MJ; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.
Rivero-Calle I; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.; Translational Pediatrics and Infectious Diseases Section, Department of Pediatrics, Hospital Clìnico Universitario de Santiago de Compostela, Galicia, Spain.
Gómez-Carballa A; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.; Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clìnico Universitario de Santiago, Servizo Galego de Saúde, Galicia, Spain.
Cebey-López M; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.
Rodríguez-Tenreiro C; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.
Dacosta-Urbieta A; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.; Translational Pediatrics and Infectious Diseases Section, Department of Pediatrics, Hospital Clìnico Universitario de Santiago de Compostela, Galicia, Spain.
Rivero-Velasco C; Intensive Medicine Department, Hospital Clìnico Universitario de Santiago de Compostela, Galicia, Spain.
Rodríguez-Núñez N; Pneumology Department, Hospital Clìnico Universitario de Santiago de Compostela, Galicia, Spain.
Trastoy-Pena R; Microbiology Department, Hospital Clìnico Universitario de Santiago de Compostela, Galicia, Spain.
Rodríguez-García J; Clinical Biochemistry Laboratory, Hospital Clìnico Universitario de Santiago de Compostela, Galicia, Spain.
Salas A; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.; Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clìnico Universitario de Santiago, Servizo Galego de Saúde, Galicia, Spain.
Martinón-Torres F; Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría, Instituto de Investigación Sanitaria de Santiago, Hospital Clinico Universitario and Universidade de Santiago de Compostela, Servizo Galego de Saúde, Galicia, Spain.; Translational Pediatrics and Infectious Diseases Section, Department of Pediatrics, Hospital Clìnico Universitario de Santiago de Compostela, Galicia, Spain.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Sep 23; Vol. 11, pp. 560381. Date of Electronic Publication: 2020 Sep 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD*/blood
Antigens, CD*/immunology
Antigens, Differentiation, Myelomonocytic*/blood
Antigens, Differentiation, Myelomonocytic*/immunology
Betacoronavirus*/immunology
Betacoronavirus*/metabolism
Coronavirus Infections*/blood
Coronavirus Infections*/drug therapy
Coronavirus Infections*/immunology
Coronavirus Infections*/pathology
Lipopolysaccharide Receptors*/blood
Lipopolysaccharide Receptors*/immunology
Pandemics*
Pneumonia, Viral*/blood
Pneumonia, Viral*/drug therapy
Pneumonia, Viral*/immunology
Pneumonia, Viral*/pathology
Receptors, Cell Surface*/blood
Receptors, Cell Surface*/immunology
Adrenal Cortex Hormones/administration & dosage ; Adult ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; COVID-19 ; Female ; Humans ; Hydroxychloroquine/administration & dosage ; Intensive Care Units ; Interleukin-6/blood ; Interleukin-6/immunology ; Macrophage Activation ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/pathology ; Patient Admission ; SARS-CoV-2 ; Time Factors
Czasopismo naukowe
Tytuł :
CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance.
Autorzy :
Xu K; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Zhou Y; State Key Laboratory of Agricultural Microbiology and Key Laboratory of Preventive Veterinary Medicine in Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Mu Y; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Liu Z; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Hou S; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Xiong Y; State Key Laboratory of Agricultural Microbiology and Key Laboratory of Preventive Veterinary Medicine in Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Fang L; State Key Laboratory of Agricultural Microbiology and Key Laboratory of Preventive Veterinary Medicine in Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Ge C; Shandong Landsee Genetics Co., Ltd., Rizhao, China.
Wei Y; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Zhang X; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Xu C; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Che J; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Fan Z; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Xiang G; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Guo J; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Shang H; Shenzhen Kingsino Technology Co., Ltd., Shenzhen, China.
Li H; College of Life Science and Engineering, Foshan University, Foshan, China.
Xiao S; State Key Laboratory of Agricultural Microbiology and Key Laboratory of Preventive Veterinary Medicine in Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Li J; Department of Animal BioSciences, University of Guelph, Ontario, Canada.
Li K; State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
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Źródło :
ELife [Elife] 2020 Sep 02; Vol. 9. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD13 Antigens/*deficiency
Coronavirus/*pathogenicity
Coronavirus Infections/*prevention & control
Gastroenteritis, Transmissible, of Swine/*prevention & control
Porcine Reproductive and Respiratory Syndrome/*prevention & control
Porcine respiratory and reproductive syndrome virus/*pathogenicity
Receptors, Cell Surface/*deficiency
Transmissible gastroenteritis virus/*pathogenicity
Animals ; Animals, Genetically Modified ; Antigens, CD/genetics ; Antigens, CD/immunology ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/immunology ; Body Composition ; CD13 Antigens/genetics ; CD13 Antigens/immunology ; Coronavirus/immunology ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Disease Susceptibility ; Gastroenteritis, Transmissible, of Swine/genetics ; Gastroenteritis, Transmissible, of Swine/immunology ; Gastroenteritis, Transmissible, of Swine/virology ; Gene Knockdown Techniques ; Host Microbial Interactions ; Meat-Packing Industry ; Phenotype ; Porcine Reproductive and Respiratory Syndrome/genetics ; Porcine Reproductive and Respiratory Syndrome/immunology ; Porcine Reproductive and Respiratory Syndrome/virology ; Porcine respiratory and reproductive syndrome virus/immunology ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/immunology ; Sus scrofa/genetics ; Swine ; Transmissible gastroenteritis virus/immunology ; Weight Gain
Czasopismo naukowe
Tytuł :
Effects of Sublethal Concentrations of Insecticides on the Fecundity of Sogatella furcifera (Hemiptera: Delphacidae) via the Regulation of Vitellogenin and Its Receptor.
Autorzy :
Zhou C; Institute of Entomology, Guizhou University and Guizhou Provincial Key Laboratory for Agricultural Pest Management of Mountainous Regions, Guiyang, China.
Yang XB; Institute of Entomology, Guizhou University and Guizhou Provincial Key Laboratory for Agricultural Pest Management of Mountainous Regions, Guiyang, China.
Yang H; Institute of Entomology, Guizhou University and Guizhou Provincial Key Laboratory for Agricultural Pest Management of Mountainous Regions, Guiyang, China.; College of Tobacco Science of Guizhou University, Guiyang, China.
Long GY; Institute of Entomology, Guizhou University and Guizhou Provincial Key Laboratory for Agricultural Pest Management of Mountainous Regions, Guiyang, China.
Jin DC; Institute of Entomology, Guizhou University and Guizhou Provincial Key Laboratory for Agricultural Pest Management of Mountainous Regions, Guiyang, China.; Scientific Observing and Experimental Station of Crop Pest in Guiyang, Ministry of Agriculture, Guiyang, China.
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Źródło :
Journal of insect science (Online) [J Insect Sci] 2020 Sep 01; Vol. 20 (5).
Typ publikacji :
Journal Article
MeSH Terms :
Egg Proteins/*drug effects
Hemiptera/*drug effects
Insecticides/*pharmacology
Receptors, Cell Surface/*drug effects
Vitellogenins/*drug effects
Animals ; Crops, Agricultural ; Egg Proteins/genetics ; Egg Proteins/metabolism ; Fertility/drug effects ; Gene Expression ; Genes, Insect ; Hemiptera/physiology ; Organothiophosphates/pharmacology ; Oryza ; Pest Control ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Reproduction/drug effects ; Thiamethoxam/pharmacology ; Triazoles/pharmacology ; Vitellogenins/genetics ; Vitellogenins/metabolism
Czasopismo naukowe
Tytuł :
Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
Autorzy :
Park DR; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea.; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, 03760, South Korea.
Kim J; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea.; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, 03760, South Korea.
Kim GM; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea.; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, 03760, South Korea.
Lee H; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea.
Kim M; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea.; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, 03760, South Korea.
Hwang D; Department of Biomedical Engineering, Yonsei University, Wonju, 26493, South Korea.
Lee H; Department of Biomedical Engineering, Yonsei University, Wonju, 26493, South Korea.
Kim HS; Department of Biomedical Engineering, Yonsei University, Wonju, 26493, South Korea.
Kim W; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea.
Park MC; Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 06273, South Korea.
Shim H; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea.
Lee SY; Department of Life Science, Ewha Womans University, Seoul, 03760, South Korea. .; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, 03760, South Korea. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 28; Vol. 11 (1), pp. 4343. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Cartilage, Articular/*metabolism
Chondrocytes/*metabolism
Osteoarthritis/*metabolism
Osteoclasts/*metabolism
Receptors, Cell Surface/*metabolism
Aged ; Animals ; Cartilage, Articular/pathology ; Chondrocytes/pathology ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Osteoarthritis/drug therapy ; Osteoarthritis/pathology ; Receptors, Cell Surface/drug effects ; Receptors, Cell Surface/genetics ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Structural elucidation of the cis -prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation.
Autorzy :
Edani BH; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Grabińska KA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Zhang R; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Park EJ; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Siciliano B; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Surmacz L; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106, Warsaw, Poland.
Ha Y; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520; .
Sessa WC; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520; .; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 25; Vol. 117 (34), pp. 20794-20802. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alkyl and Aryl Transferases/*chemistry
Alkyl and Aryl Transferases/*metabolism
Receptors, Cell Surface/*chemistry
Receptors, Cell Surface/*metabolism
Transferases/*chemistry
Transferases/*metabolism
Alkyl and Aryl Transferases/genetics ; Amino Acid Sequence ; Catalytic Domain ; Chromatography, High Pressure Liquid/methods ; Crystallography, X-Ray ; Glycosylation ; Humans ; Mutation ; Protein Domains ; Protein Structure, Secondary ; Receptors, Cell Surface/genetics ; Structure-Activity Relationship ; Transferases/genetics
Czasopismo naukowe
Tytuł :
RLP23 is required for Arabidopsis immunity against the grey mould pathogen Botrytis cinerea.
Autorzy :
Ono E; Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan.
Mise K; Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan.
Takano Y; Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 14; Vol. 10 (1), pp. 13798. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arabidopsis/*immunology
Arabidopsis Proteins/*immunology
Botrytis/*immunology
Disease Resistance/*immunology
Plant Diseases/*immunology
Receptors, Cell Surface/*immunology
Arabidopsis/genetics ; Arabidopsis/microbiology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Botrytis/genetics ; Botrytis/pathogenicity ; Disease Resistance/genetics ; Fungal Proteins/genetics ; Fungal Proteins/immunology ; Fungal Proteins/metabolism ; Gene Expression Regulation/immunology ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Mutation/immunology ; Plant Diseases/genetics ; Plant Diseases/microbiology ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Virulence/genetics ; Virulence/immunology
SCR Organism :
Botrytis cinerea
Czasopismo naukowe
Tytuł :
Molecular characterization, expression pattern and RNAi-mediated silencing of vitellogenin receptor gene in almond moth, Cadra cautella.
Autorzy :
Husain M; Economic Entomology Research Unit, Plant Protection Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
Rasool KG; Economic Entomology Research Unit, Plant Protection Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
Tufail M; Economic Entomology Research Unit, Plant Protection Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.; Ghazi University, Dera Ghazi Khan, Pakistan.
Aldawood AS; Economic Entomology Research Unit, Plant Protection Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
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Źródło :
Insect molecular biology [Insect Mol Biol] 2020 Aug; Vol. 29 (4), pp. 417-430. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
Egg Proteins/*genetics
Insect Proteins/*genetics
Moths/*genetics
Receptors, Cell Surface/*genetics
Amino Acid Sequence ; Animals ; Egg Proteins/chemistry ; Egg Proteins/metabolism ; Female ; Gene Expression Profiling ; Insect Proteins/chemistry ; Insect Proteins/metabolism ; Larva/growth & development ; Larva/metabolism ; Male ; Moths/growth & development ; Moths/metabolism ; Phylogeny ; Pupa/growth & development ; Pupa/metabolism ; RNA Interference ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/metabolism ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Expression profile of kalliklectin, a soluble-type mannose receptor, during embryogenesis and early larval development in fugu (Takifugu rubripes).
Autorzy :
Matsui S; School of Marine Biosciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
Yoshikawa S; Nagasaki Prefectural Institute of Fisheries, 1551-4, Tairamachi, Nagasaki, Nagasaki 851-2213, Japan.
Suzuki S; National Research Institute of Aquaculture, Fisheries Research Agency, 183-2, Irozaki, Minamiizu, Kamo-gun, Shizuoka 415-0156, Japan.
Somamoto T; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Motooka 744, Fukuoka, Fukuoka 819-0395, Japan.
Yamamoto A; Faculty of Fisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima, Kagoshima 890-0056, Japan.
Nakamura O; School of Marine Biosciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
Tsutsui S; School of Marine Biosciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2020 Oct; Vol. 126, pp. 129-135. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Maternally-Acquired*
Embryonic Development/*immunology
Fish Proteins/*metabolism
Lectins, C-Type/*metabolism
Mannose-Binding Lectins/*metabolism
Receptors, Cell Surface/*metabolism
Takifugu/*growth & development
Animals ; Embryo, Nonmammalian ; Female ; Fish Proteins/immunology ; Gene Expression Profiling ; Lactococcus/immunology ; Lectins, C-Type/immunology ; Mannose-Binding Lectins/immunology ; Ovum/immunology ; Ovum/metabolism ; Receptors, Cell Surface/immunology ; Streptococcus iniae/immunology ; Takifugu/immunology ; Takifugu/microbiology
SCR Organism :
Lactococcus garvieae
Czasopismo naukowe
Tytuł :
Structure of Merkel Cell Polyomavirus Capsid and Interaction with Its Glycosaminoglycan Attachment Receptor.
Autorzy :
Bayer NJ; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Januliene D; Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
Zocher G; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Stehle T; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany .; Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Moeller A; Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
Blaum BS; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
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Źródło :
Journal of virology [J Virol] 2020 Sep 29; Vol. 94 (20). Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Capsid/*metabolism
Capsid Proteins/*metabolism
Merkel cell polyomavirus/*metabolism
Receptors, Cell Surface/*metabolism
Capsid/ultrastructure ; Capsid Proteins/genetics ; Cell Line ; Cryoelectron Microscopy ; Humans ; Merkel cell polyomavirus/genetics ; Merkel cell polyomavirus/ultrastructure ; N-Acetylneuraminic Acid/genetics ; N-Acetylneuraminic Acid/metabolism ; Protein Structure, Secondary ; Receptors, Cell Surface/genetics
Czasopismo naukowe
Tytuł :
Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum.
Autorzy :
Kubiasová K; Department of Molecular Biology, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Montesinos JC; Institute of Science and Technology (IST), 3400, Klosterneuburg, Austria.
Šamajová O; Department of Cell Biology, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Nisler J; Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences and Faculty of Science of Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Mik V; Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Semerádová H; Institute of Science and Technology (IST), 3400, Klosterneuburg, Austria.
Plíhalová L; Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences and Faculty of Science of Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Novák O; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences and Faculty of Science of Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Marhavý P; Institute of Science and Technology (IST), 3400, Klosterneuburg, Austria.; Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 90183, Umeå, Sweden.
Cavallari N; Institute of Science and Technology (IST), 3400, Klosterneuburg, Austria.
Zalabák D; Department of Molecular Biology, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Berka K; Department of Physical Chemistry, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University, 17. listopadu 1192/12, 771 46, Olomouc, Czech Republic.
Doležal K; Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences and Faculty of Science of Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Galuszka P
Šamaj J; Department of Cell Biology, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Strnad M; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences and Faculty of Science of Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.
Benková E; Institute of Science and Technology (IST), 3400, Klosterneuburg, Austria. .
Plíhal O; Department of Molecular Biology, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic. .; Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic. .; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences and Faculty of Science of Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic. .
Spíchal L; Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 27; Vol. 11 (1), pp. 4285. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arabidopsis Proteins/*metabolism
Cell Membrane/*metabolism
Cytokinins/*metabolism
Endoplasmic Reticulum/*metabolism
Fluorescent Dyes/*chemistry
Protein Kinases/*metabolism
Receptors, Cell Surface/*metabolism
Arabidopsis/cytology ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Brefeldin A/pharmacology ; Cytokinins/chemistry ; Fluorescent Dyes/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Meristem/cytology ; Meristem/metabolism ; Plants, Genetically Modified ; Protein Kinases/genetics ; Receptors, Cell Surface/genetics ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Rational design to control the trade-off between receptor affinity and cooperativity.
Autorzy :
Ortega G; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106.; Center for Bioengineering, University of California, Santa Barbara, CA 93106.
Mariottini D; Department of Chemistry, University of Rome Tor Vergata, 00173 Rome, Italy.
Troina A; Department of Chemistry, University of Rome Tor Vergata, 00173 Rome, Italy.
Dahlquist FW; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106.; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.
Ricci F; Department of Chemistry, University of Rome Tor Vergata, 00173 Rome, Italy.
Plaxco KW; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106; .; Center for Bioengineering, University of California, Santa Barbara, CA 93106.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 19136-19140. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Receptors, Cell Surface/*chemistry
Binding Sites ; Doxorubicin/chemistry ; Doxorubicin/metabolism ; Kinetics ; Ligands ; Protein Binding ; Receptors, Cell Surface/metabolism
Czasopismo naukowe
Tytuł :
Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Autorzy :
Svendsen P; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Etzerodt A; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Deleuran BW; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
Moestrup SK; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark. .; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. .; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 24; Vol. 10 (1), pp. 12447. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Experimental/*immunology
Arthritis, Rheumatoid/*immunology
Receptors, Cell Surface/*deficiency
Animals ; Antigens, CD/genetics ; Antigens, CD/immunology ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/immunology ; Arthritis, Experimental/blood ; Arthritis, Experimental/diagnosis ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/pathology ; Collagen Type II/immunology ; Cytokines/blood ; Cytokines/immunology ; Cytokines/metabolism ; Disease Progression ; Humans ; Joints/immunology ; Joints/pathology ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Mice, Knockout ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/immunology ; Severity of Illness Index ; Synovial Fluid/immunology ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Th1-Th2 Balance ; Th2 Cells/immunology ; Th2 Cells/metabolism
Czasopismo naukowe
Tytuł :
Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors with the CD206-Binding mUNO Peptide.
Autorzy :
Lepland A; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
Asciutto EK; School of Science and Technology, National University of San Martin (UNSAM) and CONICET, Campus Migueletes, 25 de Mayo y Francia, San Martı́n Buenos AiresCP 1650, Argentina.
Malfanti A; Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, Valencia 46012, Spain.
Simón-Gracia L; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
Sidorenko V; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
Vicent MJ; Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, Valencia 46012, Spain.
Teesalu T; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.; Center for Nanomedicine and Department of Cell, Molecular and Developmental Biology, University of California, Santa Barbara, California 93106, United States.; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States.
Scodeller P; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
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Źródło :
Molecular pharmaceutics [Mol Pharm] 2020 Jul 06; Vol. 17 (7), pp. 2518-2531. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy/*methods
Lectins, C-Type/*chemistry
Lung Neoplasms/*diagnosis
Lymphatic Metastasis/*diagnosis
Mannose-Binding Lectins/*chemistry
Peptides/*chemistry
Receptors, Cell Surface/*chemistry
Triple Negative Breast Neoplasms/*diagnosis
Tumor-Associated Macrophages/*immunology
Animals ; Binding Sites ; Cell Differentiation ; Cell Line, Tumor ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Drug Carriers/pharmacokinetics ; Female ; Fluorescence ; Humans ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/immunology ; Lysosomes/metabolism ; Maleimides/chemistry ; Mannose-Binding Lectins/immunology ; Mannose-Binding Lectins/metabolism ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Transmission ; Peptides/administration & dosage ; Peptides/metabolism ; Peptides/pharmacokinetics ; Polyesters/chemistry ; Polyethylene Glycols/chemistry ; Polymers/administration & dosage ; Polymers/chemistry ; Polymers/pharmacology ; Receptors, Cell Surface/immunology ; Receptors, Cell Surface/metabolism ; Triple Negative Breast Neoplasms/diagnostic imaging ; Triple Negative Breast Neoplasms/pathology ; Tumor-Associated Macrophages/metabolism
Czasopismo naukowe
Tytuł :
Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals.
Autorzy :
Tang M; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Gao S; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Zhang L; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Liu B; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Li J; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wang Z; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Zhang W; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
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Źródło :
The Prostate [Prostate] 2020 Jul; Vol. 80 (10), pp. 742-752. Date of Electronic Publication: 2020 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Docetaxel/*adverse effects
Killer Cells, Natural/*drug effects
Lectins, C-Type/*immunology
Prostatic Neoplasms, Castration-Resistant/*immunology
Prostatic Neoplasms, Castration-Resistant/*therapy
Receptors, Androgen/*immunology
Receptors, Cell Surface/*immunology
Androgen Receptor Antagonists/pharmacology ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Coculture Techniques ; Combined Modality Therapy ; Curcumin/analogs & derivatives ; Curcumin/pharmacology ; Docetaxel/therapeutic use ; HEK293 Cells ; Humans ; Immunotherapy, Adoptive/methods ; Killer Cells, Natural/immunology ; Killer Cells, Natural/transplantation ; Lectins, C-Type/antagonists & inhibitors ; Lectins, C-Type/biosynthesis ; Male ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Receptors, Androgen/biosynthesis ; Receptors, Androgen/genetics ; Receptors, Cell Surface/antagonists & inhibitors ; Receptors, Cell Surface/biosynthesis ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Nogo-B fosters HCC progression by enhancing Yap/Taz-mediated tumor-associated macrophages M2 polarization.
Autorzy :
Zhao X; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University of Chongqing, 400010, PR China.
Wang X; Department of Anesthesia, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
You Y; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University of Chongqing, 400010, PR China.
Wen D; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University of Chongqing, 400010, PR China.
Feng Z; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University of Chongqing, 400010, PR China.
Zhou Y; Department of Hepatobiliary Surgery, People's Hospital of Kaizhou, Chongqing, 400010, PR China.
Que K; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University of Chongqing, 400010, PR China.
Gong J; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University of Chongqing, 400010, PR China.
Liu Z; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University of Chongqing, 400010, PR China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Jun 01; Vol. 391 (1), pp. 111979. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adaptor Proteins, Signal Transducing/*genetics
Carcinoma, Hepatocellular/*genetics
Liver Neoplasms/*genetics
Receptors, Cell Surface/*genetics
Trans-Activators/*genetics
Transcription Factors/*genetics
Tumor-Associated Macrophages/*metabolism
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/metabolism ; Aged ; Animals ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/surgery ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Disease Progression ; Female ; Humans ; Interleukin-4/genetics ; Interleukin-4/metabolism ; Liver Neoplasms/diagnosis ; Liver Neoplasms/mortality ; Liver Neoplasms/surgery ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Prognosis ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptors, Cell Surface/antagonists & inhibitors ; Receptors, Cell Surface/metabolism ; Signal Transduction ; Survival Analysis ; Trans-Activators/metabolism ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism ; Tumor-Associated Macrophages/drug effects ; Tumor-Associated Macrophages/pathology ; Verteporfin/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The membrane receptors that appeared before their ligand: The different proposed scenarios.
Autorzy :
Grandchamp A; PRC, UMR85, INRA, CNRS, IFCE, Université de Tours, Nouzilly, France.
Monget P; PRC, UMR85, INRA, CNRS, IFCE, Université de Tours, Nouzilly, France.
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Źródło :
PloS one [PLoS One] 2020 May 22; Vol. 15 (5), pp. e0231813. Date of Electronic Publication: 2020 May 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Ligands*
Receptors, Cell Surface*/genetics
Receptors, Cell Surface*/metabolism
Binding Sites/*genetics
Protein Binding/*genetics
Amino Acid Sequence/genetics ; Animals ; Computer Simulation ; Humans ; Models, Molecular ; Molecular Conformation
Czasopismo naukowe

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