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Wyszukujesz frazę ""Receptors, Chimeric Antigen"" wg kryterium: Temat


Tytuł :
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression.
Autorzy :
Fousek K; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Watanabe J; Division of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Joseph SK; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
George A; Division of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, United States.
An X; Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA.
Byrd TT; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Morris JS; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Luong A; Division of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, United States.; University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Martínez-Paniagua MA; Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA.
Sanber K; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Navai SA; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Gad AZ; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Salsman VS; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Mathew PR; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Kim HN; Division of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, United States.; University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Wagner DL; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Institute of Medical Immunology, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health-Center for Regenerative Therapies (B-CRT), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Brunetti L; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.
Jang A; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.
Baker ML; National Center for Macromolecular Imaging and Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
Varadarajan N; Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA.
Hegde M; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Kim YM; Division of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, United States.; University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Heisterkamp N; Division of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, United States.; University of Southern California Keck School of Medicine, Los Angeles, CA, USA.; Department of Systems Biology, Beckman Research Institute City of Hope, Duarte, CA, United States.
Abdel-Azim H; Division of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, United States. .; University of Southern California Keck School of Medicine, Los Angeles, CA, USA. .
Ahmed N; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA. .; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. .; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. .; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. .
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Źródło :
Leukemia [Leukemia] 2021 Jan; Vol. 35 (1), pp. 75-89. Date of Electronic Publication: 2020 Mar 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunotherapy, Adoptive*/methods
Antigens, CD19/*immunology
Leukemia, B-Cell/*immunology
Leukemia, B-Cell/*metabolism
Receptors, Antigen, T-Cell/*immunology
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Animals ; Antigens, CD19/chemistry ; Antigens, Neoplasm ; Biomarkers ; Cell Line, Tumor ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Gene Expression ; Humans ; Leukemia, B-Cell/genetics ; Leukemia, B-Cell/therapy ; Mice, Transgenic ; Protein Binding ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; Structure-Activity Relationship ; Transduction, Genetic ; Transgenes ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Using single-cell analysis to predict CAR T cell outcomes.
Autorzy :
Ramakrishna S; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
Shah NN; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. .
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Źródło :
Nature medicine [Nat Med] 2020 Dec; Vol. 26 (12), pp. 1813-1814.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Neoplasms*
Receptors, Chimeric Antigen*/genetics
Receptors, Chimeric Antigen*/metabolism
Brain/metabolism ; Humans ; Immunotherapy ; Immunotherapy, Adoptive ; Single-Cell Analysis ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
[Neurotoxicities Associated with CAR-T Cell Therapy].
Autorzy :
Takao M; Department of Clinical Laboratory, National Center of Neurology and Psychiatry (NCNP) National Center Hospital.
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Źródło :
Brain and nerve = Shinkei kenkyu no shinpo [Brain Nerve] 2021 Jan; Vol. 73 (1), pp. 47-58.
Typ publikacji :
Journal Article
MeSH Terms :
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Receptors, Chimeric Antigen*
Cell- and Tissue-Based Therapy ; Humans ; Immunotherapy, Adoptive ; Japan
Czasopismo naukowe
Tytuł :
A novel chimeric antigen receptor redirecting T-cell specificity towards CD26 cancer cells.
Autorzy :
Zhou S; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li W; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xiao Y; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhu X; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhong Z; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li Q; Department of Hematology, Wuhan No.1 Hospital, Wuhan, 430022, China.
Cheng F; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zou P; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
You Y; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .
Zhu X; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .
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Źródło :
Leukemia [Leukemia] 2021 Jan; Vol. 35 (1), pp. 119-129. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive*/adverse effects
Immunotherapy, Adoptive*/methods
Dipeptidyl Peptidase 4/*immunology
Receptors, Antigen, T-Cell/*immunology
Receptors, Chimeric Antigen/*immunology
T-Cell Antigen Receptor Specificity/*immunology
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Animals ; Biomarkers ; Cell Line, Tumor ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Gene Expression Profiling ; Humans ; Immunophenotyping ; Mice ; Neoplasms/immunology ; Neoplasms/therapy ; Receptors, Antigen, T-Cell/genetics ; Receptors, Chimeric Antigen/genetics ; T-Cell Antigen Receptor Specificity/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
CD103 T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
Autorzy :
Kuhn NF; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
Lopez AV; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Li X; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cai W; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Daniyan AF; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brentjens RJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 02; Vol. 11 (1), pp. 6171. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD40 Ligand/*genetics
CD8-Positive T-Lymphocytes/*immunology
Dendritic Cells/*immunology
Immunotherapy, Adoptive/*methods
Lymphoma, B-Cell/*therapy
Receptors, Chimeric Antigen/*genetics
Adaptive Immunity ; Animals ; Antigen Presentation ; Antigens, CD/genetics ; Antigens, CD/immunology ; Basic-Leucine Zipper Transcription Factors/deficiency ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/immunology ; CD11b Antigen/deficiency ; CD11b Antigen/genetics ; CD11b Antigen/immunology ; CD40 Ligand/immunology ; CD8-Positive T-Lymphocytes/cytology ; Dendritic Cells/cytology ; Female ; Gene Expression ; Immunity, Innate ; Immunophenotyping ; Integrin alpha Chains/deficiency ; Integrin alpha Chains/genetics ; Integrin alpha Chains/immunology ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Neoplasm Transplantation ; Receptors, Chimeric Antigen/immunology ; Repressor Proteins/deficiency ; Repressor Proteins/genetics ; Repressor Proteins/immunology
Czasopismo naukowe
Tytuł :
Head and Neck Dystonia Following Chimeric-Antigen Receptor T-Cell Immunotherapy: A Case Report.
Autorzy :
Lee DD; Division of Otolaryngology and Head-Neck Surgery, Department of Surgery, Albany Medical Center, Albany, New York, U.S.A.
Lin Y; Division of Otolaryngology and Head-Neck Surgery, Department of Surgery, Albany Medical Center, Albany, New York, U.S.A.
Galati LT; Division of Otolaryngology and Head-Neck Surgery, Department of Surgery, Albany Medical Center, Albany, New York, U.S.A.
Shapshay SM; Division of Otolaryngology and Head-Neck Surgery, Department of Surgery, Albany Medical Center, Albany, New York, U.S.A.
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Źródło :
The Laryngoscope [Laryngoscope] 2020 Dec; Vol. 130 (12), pp. E863-E864. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Receptors, Chimeric Antigen*/therapeutic use
Dystonia/*etiology
Immunotherapy, Adoptive/*adverse effects
Laryngeal Diseases/*etiology
Pharyngeal Diseases/*etiology
Female ; Humans ; Lymphoma, Follicular/therapy ; Middle Aged
Czasopismo naukowe
Tytuł :
[Quality assessment of CAR T-cell activity: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
Autorzy :
Duléry R; AP-HP, hôpital Saint-Antoine, Sorbonne Université, service d'hématologie clinique et thérapie cellulaire, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France. Electronic address: .
Lacassagne MN; CHU Amiens Sud, unité de thérapie cellulaire, 1, rue du Professeur Christian-Cabrol, 80054 Amiens, France.
Giraud C; CHU de Poitiers, service d'oncologie hématologique et thérapie cellulaire et EFS Nouvelle Aquitaine, unité d'aphérèse et thérapie cellulaire, 2, rue de la Milétrie, 86021 Poitiers, France.
Ader V; EFS Occitanie, institut universitaire du cancer Toulouse Oncopole, unité d'aphérèse, avenue de Grande-Bretagne, 31300 Toulouse, France.
Beaumont JL; CHU Henri Mondor, unité d'aphérèses thérapeutiques, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
Carnoy S; CHRU de Lille, unité d'aphérèse, 2, avenue Oscar-Lambret, 59000 Lille, France.
Carpentier A; CHU de Liège, Cellular Therapy Lab, avenue de L'Hôpital 1, 4000 Liège, Belgique.
Fegueux N; CHU de Montpellier, service d'hématologie clinique, 191, avenue du Doyen-Giraud, 34295 Montpellier cedex 5, France.
Gibault-Joffe C; Hôpital universitaire de Genève, rue Gabrielle-Perret-Gentil 4, 1205 Genève, Suisse.
Guerout-Verite MA; EFS Bretagne, unité de thérapie cellulaire, rue Pierre-Jean-Gineste, BP 91614, Rennes cedex, France.
Huynh TNP; Institut Jules-Bordet, université Libre de Bruxelles, unité de thérapie cellulaire hématologique, service d'Hématologie, 121-125, boulevard de Waterloo, 1000 Bruxelles, Belgique.
Lewalle P; Institut Jules-Bordet, université Libre de Bruxelles, unité de thérapie cellulaire hématologique, service d'Hématologie, 121-125, boulevard de Waterloo, 1000 Bruxelles, Belgique.
Perrin A; CHRU de Lille, gestion du risque infectieux, des vigilances et infectiologie (SGRIVI), 2, avenue Oscar-Lambret, 59000 Lille, France.
Plaza-Milhe S; CHU de Montpellier, service d'hématologie clinique, 191, avenue du Doyen-Giraud, 34295 Montpellier cedex 5, France.
Bonnin A; Hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
Yakoub-Agha I; CHU de Lille, université Lille, Inserm U1286, INFINITE, 2, avenue Oscar-Lambret, 59000 Lille, France.
Contentin N; Centre Henri-Becquerel, service d'hématologie, 1, rue d'Amiens, 76038 Rouen, France.
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Transliterated Title :
Mutualisation des outils de qualité pour les cellules CAR-T : recommandations de la Société francophone de greffe de moelle et thérapie cellulaire (SFGM-TC).
Źródło :
Bulletin du cancer [Bull Cancer] 2020 Dec; Vol. 107 (12S), pp. S193-S201. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Practice Guideline
MeSH Terms :
Quality Assurance, Health Care*
Receptors, Chimeric Antigen*
Immunotherapy, Adoptive/*standards
Accreditation ; Congresses as Topic/organization & administration ; France ; Health Personnel/education ; Humans ; Immunotherapy, Adoptive/legislation & jurisprudence ; Societies, Medical
Czasopismo naukowe
Tytuł :
[Chimeric antigen receptors in oncology: clinical applications and new developments].
Autorzy :
Michels A; Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Deutschland.
Hartmann J; Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Deutschland.
Buchholz CJ; Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Deutschland. .
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Transliterated Title :
Chimäre Antigenrezeptoren (CARs) in der Onkologie: eine Übersicht zu klinischer Anwendung und neuen Entwicklungen.
Źródło :
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz [Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz] 2020 Nov; Vol. 63 (11), pp. 1331-1340. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Receptors, Chimeric Antigen*
Animals ; Germany ; Humans ; Immunotherapy, Adoptive ; Medical Oncology ; Receptors, Antigen, T-Cell/genetics ; T-Lymphocytes
Czasopismo naukowe
Tytuł :
Chimeric antigen receptor T-cell therapy for acute lymphocytic leukaemia: where are we in 2020?
Autorzy :
Laetsch TW; Division of Oncology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: .
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Źródło :
The Lancet. Haematology [Lancet Haematol] 2020 Nov; Vol. 7 (11), pp. e778-e779.
Typ publikacji :
Journal Article
MeSH Terms :
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Receptors, Chimeric Antigen*
Acute Disease ; Cell- and Tissue-Based Therapy ; Humans ; Immunotherapy, Adoptive
Czasopismo naukowe
Tytuł :
Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo.
Autorzy :
Maldini CR; Department of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Claiborne DT; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Okawa K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Chen T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Dopkin DL; Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shan X; Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Power KA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Trifonova RT; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Krupp K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Phelps M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Vrbanac VD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Human Immune System Mouse Program, Massachusetts General Hospital, Boston, MA, USA.
Tanno S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Human Immune System Mouse Program, Massachusetts General Hospital, Boston, MA, USA.
Bateson T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Leslie GJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hoxie JA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Boutwell CL; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Riley JL; Department of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
Allen TM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. .
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Źródło :
Nature medicine [Nat Med] 2020 Nov; Vol. 26 (11), pp. 1776-1787. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive*
CD4 Antigens/*immunology
HIV Infections/*therapy
Receptors, Chimeric Antigen/*immunology
Animals ; Antibodies, Monoclonal, Humanized/immunology ; Antibodies, Monoclonal, Humanized/pharmacology ; Bone Marrow/immunology ; Bone Marrow/virology ; CD3 Complex/antagonists & inhibitors ; CD4 Antigens/administration & dosage ; Gene Expression Regulation/immunology ; HIV Envelope Protein gp41/antagonists & inhibitors ; HIV Envelope Protein gp41/immunology ; HIV Infections/immunology ; HIV Infections/pathology ; HIV Infections/virology ; HIV-1/immunology ; HIV-1/pathogenicity ; Humans ; Liver/immunology ; Liver/virology ; Mice ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/immunology ; Protein Domains/immunology ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/immunology ; Receptors, Chimeric Antigen/administration & dosage ; T-Lymphocytes/immunology ; Thymus Gland/immunology ; Thymus Gland/virology ; Tumor Necrosis Factor Receptor Superfamily, Member 9/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.
Autorzy :
Heczey A; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA. .; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. .; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. .
Courtney AN; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Montalbano A; Immunai Inc., New York, NY, USA.
Robinson S; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Liu K; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Li M; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Ghatwai N; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Dakhova O; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Liu B; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Raveh-Sadka T; Immunai Inc., New York, NY, USA.
Chauvin-Fleurence CN; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Xu X; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Ngai H; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Di Pierro EJ; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Savoldo B; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Dotti G; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Metelitsa LS; Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA. .; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. .; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. .
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Źródło :
Nature medicine [Nat Med] 2020 Nov; Vol. 26 (11), pp. 1686-1690. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bone Neoplasms/*drug therapy
Natural Killer T-Cells/*drug effects
Neuroblastoma/*drug therapy
Receptors, Chimeric Antigen/*genetics
Bone Neoplasms/immunology ; Bone Neoplasms/pathology ; Bone Neoplasms/secondary ; Child ; Cyclophosphamide/administration & dosage ; Drug Resistance, Neoplasm/immunology ; Humans ; Immunity/drug effects ; Immunotherapy, Adoptive/methods ; Lymphocyte Activation/immunology ; Male ; Natural Killer T-Cells/immunology ; Neuroblastoma/genetics ; Neuroblastoma/immunology ; Neuroblastoma/pathology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Chimeric Antigen/immunology ; Vidarabine/administration & dosage ; Vidarabine/analogs & derivatives
Czasopismo naukowe
Tytuł :
CAR-T in solid tumors: Blazing a new trail through the brambles.
Autorzy :
Guo F; Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
Cui J; Cancer Center, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118300. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunotherapy, Adoptive*/methods
Immunotherapy, Adoptive*/trends
Receptors, Chimeric Antigen*
Neoplasms/*therapy
Antigens, Neoplasm/immunology ; Humans ; Immune Tolerance ; Tumor Microenvironment/physiology
Czasopismo naukowe
Tytuł :
Adenovirus-mediated specific tumor tagging facilitates CAR-T therapy against antigen-mismatched solid tumors.
Autorzy :
Tang X; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China.
Li Y; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China.
Ma J; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China.
Wang X; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China.
Zhao W; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China.
Hossain MA; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China.
Yang Y; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Sep 01; Vol. 487, pp. 1-9. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive*
Antigens, Neoplasm/*immunology
Receptors, Antigen, T-Cell/*immunology
Receptors, Chimeric Antigen/*immunology
Adenoviridae/genetics ; Animals ; Antigens, CD19/genetics ; Antigens, CD19/immunology ; Antigens, CD19/therapeutic use ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/therapeutic use ; Cell Line, Tumor ; Combined Modality Therapy ; Humans ; Immunological Synapses/drug effects ; Immunological Synapses/genetics ; Immunological Synapses/immunology ; Mice ; Oncolytic Virotherapy/trends ; Oncolytic Viruses/genetics ; Receptors, Antigen, T-Cell/genetics ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/therapeutic use ; T-Lymphocytes/immunology ; T-Lymphocytes/virology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function.
Autorzy :
Salzer B; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria.
Schueller CM; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.
Zajc CU; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria.
Peters T; Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Schoeber MA; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.
Kovacic B; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.
Buri MC; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.
Lobner E; Department of Biotechnology, University of Natural Resources and Life Sciences, 1190, Vienna, Austria.
Dushek O; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.
Huppa JB; Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Obinger C; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, 1190, Vienna, Austria.
Putz EM; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.
Holter W; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.; Department of Pediatrics, St. Anna Kinderspital, Medical University of Vienna, 1090, Vienna, Austria.
Traxlmayr MW; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria. .; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, 1190, Vienna, Austria. .
Lehner M; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria. .; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria. .; Department of Pediatrics, St. Anna Kinderspital, Medical University of Vienna, 1090, Vienna, Austria. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 20; Vol. 11 (1), pp. 4166. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive/*methods
Receptors, Antigen, T-Cell/*immunology
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
Animals ; Antigens, Neoplasm/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cells, Cultured ; Cytokines/immunology ; Cytokines/metabolism ; Cytotoxicity, Immunologic/immunology ; Humans ; Lymphocyte Activation/immunology ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells.
Autorzy :
Yamamoto S; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. .
Matsumoto SI; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan.
Goto A; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan.
Ugajin M; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan.
Nakayama M; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan.
Moriya Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan.
Hirabayashi H; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan.
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 21; Vol. 10 (1), pp. 17884. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Chimeric Antigen/*genetics
T-Lymphocytes/*metabolism
Humans ; Real-Time Polymerase Chain Reaction ; Receptors, Chimeric Antigen/metabolism
Czasopismo naukowe
Tytuł :
SJI 2020 special issue: A catalogue of Ovarian Cancer targets for CAR therapy.
Autorzy :
Benard E; Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.
Casey NP; Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.
Inderberg EM; Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.
Wälchli S; Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Oct; Vol. 92 (4), pp. e12917.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinoma, Ovarian Epithelial/*immunology
Ovarian Neoplasms/*immunology
Receptors, Chimeric Antigen/*immunology
Tumor Microenvironment/*immunology
Animals ; Antigens, Neoplasm/immunology ; Carcinoma, Ovarian Epithelial/therapy ; Female ; Humans ; Immunotherapy, Adoptive/methods ; Ovarian Neoplasms/therapy ; Receptors, Chimeric Antigen/therapeutic use ; Tumor Escape/immunology
Czasopismo naukowe
Tytuł :
Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells.
Autorzy :
Myburgh R; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Kiefer JD; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Russkamp NF; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Magnani CF; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Nuñez N; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Simonis A; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Pfister S; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Wilk CM; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
McHugh D; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Friemel J; Institute of Pathology and Molecular Pathology, University and University Hospital Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Müller AM; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Becher B; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Münz C; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
van den Broek M; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Neri D; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland. .
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Źródło :
Leukemia [Leukemia] 2020 Oct; Vol. 34 (10), pp. 2688-2703. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive*
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Receptors, Antigen, T-Cell/*immunology
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Animals ; Biomarkers ; Biopsy ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Gene Expression ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/metabolism ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Humans ; Immunophenotyping ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Lymphocyte Depletion ; Mice ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Chimeric Antigen/genetics ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Structure-function relationships of chimeric antigen receptors in acute T cell responses to antigen.
Autorzy :
Xu H; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Hamburger AE; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Mock JY; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Wang X; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Martin AD; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Tokatlian T; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Oh J; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Daris ME; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Negri KR; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Gabrelow GB; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Wu ML; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Nampe DP; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Asuelime GE; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
McElvain ME; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Sandberg ML; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States.
Kamb A; A2 Biotherapeutics, 30301 Agoura Rd., Agoura Hills, CA, 91301, United States. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2020 Oct; Vol. 126, pp. 56-64. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
HLA-A Antigens/*immunology
Receptors, Chimeric Antigen/*metabolism
Signal Transduction/*immunology
T-Lymphocytes/*immunology
Binding Sites/immunology ; HLA-A Antigens/metabolism ; Humans ; Jurkat Cells ; Ligands ; MCF-7 Cells ; Protein Domains/immunology ; Protein Multimerization/immunology ; Receptors, Chimeric Antigen/immunology ; Structure-Activity Relationship ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
CAR T-cells: hot news in cancer therapy.
Autorzy :
Hrabovský Š
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Transliterated Title :
CAR T-lymfocyty: horká novinka v léčbě nádorů.
Źródło :
Vnitrni lekarstvi [Vnitr Lek] 2020 Fall; Vol. 66 (7), pp. 420-424.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasms*/therapy
Receptors, Chimeric Antigen*
Czech Republic ; Humans ; Immunotherapy, Adoptive ; Receptors, Antigen, T-Cell ; T-Lymphocytes
Czasopismo naukowe

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