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Wyszukujesz frazę ""Receptors, Cytoplasmic and Nuclear"" wg kryterium: Temat


Tytuł :
An ancestral nuclear receptor couple, PPAR-RXR, is exploited by organotins.
Autorzy :
Capitão AMF; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto (U.Porto), Matosinhos, Portugal; Faculty of Sciences (FCUP), University of Porto (U.Porto), Department of Biology, Porto, Portugal.
Lopes-Marques M; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto (U.Porto), Matosinhos, Portugal.
Páscoa I; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto (U.Porto), Matosinhos, Portugal.
Sainath SB; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto (U.Porto), Matosinhos, Portugal; Department of Biotechnology, Vikrama Simhapuri University, Nellore 524 003, AP, India.
Hiromori Y; Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan; Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, Gifu, Japan.
Matsumaru D; Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, Gifu, Japan.
Nakanishi T; Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, Gifu, Japan.
Ruivo R; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto (U.Porto), Matosinhos, Portugal.
Santos MM; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto (U.Porto), Matosinhos, Portugal; Faculty of Sciences (FCUP), University of Porto (U.Porto), Department of Biology, Porto, Portugal. Electronic address: .
Castro LFC; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto (U.Porto), Matosinhos, Portugal; Faculty of Sciences (FCUP), University of Porto (U.Porto), Department of Biology, Porto, Portugal. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Nov 25; Vol. 797, pp. 149044. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Peroxisome Proliferator-Activated Receptors*/genetics
Receptors, Cytoplasmic and Nuclear*
Animals ; Humans ; Lipids ; Retinoid X Receptors
Czasopismo naukowe
Tytuł :
LRH-1 high expression in the ovarian granulosa cells of PCOS patients.
Autorzy :
Yang X; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.
Wang Q; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.
Wang Y; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.
Song T; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.
Zheng Y; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.
Wang W; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.
Shi Y; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. .; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China. .; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China. .; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China. .; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China. .
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Źródło :
Endocrine [Endocrine] 2021 Nov; Vol. 74 (2), pp. 413-420. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Polycystic Ovary Syndrome*/genetics
Receptors, Cytoplasmic and Nuclear*/genetics
Granulosa Cells/*metabolism
Anti-Mullerian Hormone ; Female ; Follicular Fluid ; Humans
Czasopismo naukowe
Tytuł :
Farnesoid X receptor (FXR) inhibits coagulation process via inducing hepatic antithrombin III expression in mice.
Autorzy :
Luan ZL; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Wei YY; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Wang YC; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.
Ming WH; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.
Zhang HB; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.
Wang B; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.; Department of Endocrinology, Dalian Municipal Central Hospital, Dalian Medical University, Dalian 116033, China.
Cui XH; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Li YY; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Guan YF; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Zhang XY; Health Science Center, East China Normal University, Shanghai 200241, China. .
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2021 Oct 25; Vol. 73 (5), pp. 795-804.
Typ publikacji :
Journal Article
MeSH Terms :
Antithrombin III*
Hepatocytes*
Receptors, Cytoplasmic and Nuclear*/genetics
Animals ; Blood Coagulation ; Liver ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
FBXO22, ubiquitination degradation of PHLPP1, ameliorates rotenone induced neurotoxicity by activating AKT pathway.
Autorzy :
Zheng X; School of Medicine, Southeast University, Nanjing City, Jiangsu Province, 210009, China; Department of Neurology, The 904th Hospital of Joint Logistic Support Force, PLA, Changzhou District, Changzhou City, Jiangsu Province, 213003, China.
Yu S; Department of Neurology, The 904th Hospital of Joint Logistic Support Force, PLA, Changzhou District, Changzhou City, Jiangsu Province, 213003, China.
Xue Y; Department of Neurology, The 904th Hospital of Joint Logistic Support Force, PLA, Changzhou District, Changzhou City, Jiangsu Province, 213003, China.
Yan F; Department of Neurology, Zhongda Hospital Affiliated to Southeast University, No. 87 Dingjiaqiao, Nanjing City, Jiangsu Province, 210009, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 10; Vol. 350, pp. 1-9. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
F-Box Proteins/*metabolism
Nuclear Proteins/*metabolism
Parkinson Disease/*drug therapy
Parkinson Disease/*genetics
Parkinson Disease/*physiopathology
Phosphoprotein Phosphatases/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Rotenone/*toxicity
Animals ; Apoptosis/drug effects ; Cells, Cultured/drug effects ; Down-Regulation/drug effects ; F-Box Proteins/genetics ; Gene Expression Regulation/drug effects ; Humans ; Male ; Models, Animal ; Neuroblastoma/drug therapy ; Neurotoxins/toxicity ; Phosphoprotein Phosphatases/genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear/genetics ; Rotenone/therapeutic use ; Signal Transduction/drug effects ; Ubiquitination
Czasopismo naukowe
Tytuł :
Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging.
Autorzy :
Kim AK; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, 34141, South Korea.
Kwon DW; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, 34141, South Korea; Department of Functional Genomics, UST, Daejeon, 34113, South Korea.
Yeom E; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, 34141, South Korea; Tunneling Nanotube Research Cnter, Korea University, Seoul, 02841, South Korea.
Lee KP; Department of Functional Genomics, UST, Daejeon, 34113, South Korea; Aging Research Center, KRIBB, Daejeon, 34141, South Korea; Aventi Inc. Daejeon, 34141, South Korea.
Kwon KS; Department of Functional Genomics, UST, Daejeon, 34113, South Korea; Aging Research Center, KRIBB, Daejeon, 34141, South Korea; Aventi Inc. Daejeon, 34141, South Korea.
Yu K; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, 34141, South Korea; Department of Functional Genomics, UST, Daejeon, 34113, South Korea; Convergence Research Center of Dementia, KIST, Seoul, 02792, South Korea. Electronic address: .
Lee KS; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, 34141, South Korea; Department of Functional Genomics, UST, Daejeon, 34113, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 03; Vol. 568, pp. 95-102. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila/*physiology
Drosophila Proteins/*metabolism
Mitochondria/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Drosophila/genetics ; Drosophila Proteins/genetics ; Female ; Gene Knockdown Techniques ; Longevity ; Male ; Mitochondria/genetics ; Mitochondrial Turnover ; Receptors, Cytoplasmic and Nuclear/genetics
Czasopismo naukowe
Tytuł :
Lipophorin receptor regulates the cuticular hydrocarbon accumulation and adult fecundity of the pea aphid Acyrthosiphon pisum.
Autorzy :
Qiao JW; State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
Fan YL; State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
Bai TT; State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
Wu BJ; State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
Pei XJ; State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
Wang D; State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
Liu TX; State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
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Źródło :
Insect science [Insect Sci] 2021 Aug; Vol. 28 (4), pp. 1018-1032. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aphids*/genetics
Aphids*/physiology
Receptors, Cytoplasmic and Nuclear*/genetics
Receptors, Cytoplasmic and Nuclear*/metabolism
Hydrocarbons/*metabolism
Animals ; Fertility/genetics ; Genes, Insect ; Insect Proteins/genetics ; Pest Control/trends ; Phylogeny ; RNA Interference ; Stress, Physiological/genetics
Czasopismo naukowe
Tytuł :
Identification and characterization of novel splice variants of human farnesoid X receptor.
Autorzy :
Mustonen EK; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany.
Lee SML; Biobank of the Department of General, Visceral and Transplantation Surgery, University Hospital LMU Munich, Munich, Germany.
Nieß H; Biobank of the Department of General, Visceral and Transplantation Surgery, University Hospital LMU Munich, Munich, Germany.
Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany; Departments of Clinical Pharmacology, and Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.
Pantsar T; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Burk O; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Jul 15; Vol. 705, pp. 108893. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Humans ; Mutation ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Receptors, Cytoplasmic and Nuclear/chemistry ; Receptors, Cytoplasmic and Nuclear/genetics
Czasopismo naukowe
Tytuł :
Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity.
Autorzy :
von Fallois M; Universität Zu Lübeck, Institut Für Physiologie, Working Group Hypoxia, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Kosyna FK; Universität Zu Lübeck, Institut Für Physiologie, Working Group Hypoxia, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Mandl M; Universität Zu Lübeck, Institut Für Physiologie, Working Group Hypoxia, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Landesman Y; Karyopharm Therapeutics, 85 Wells Ave, Newton, MA, 02459, USA.
Dunst J; Universitätsklinikum Schleswig-Holstein, Campus Kiel-Klinik für Strahlentherapie, Arnold-Heller-Straße 3, 24105, Kiel, Germany.
Depping R; Universität Zu Lübeck, Institut Für Physiologie, Working Group Hypoxia, Ratzeburger Allee 160, 23562, Lübeck, Germany. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Jul; Vol. 147 (7), pp. 2025-2033. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*radiotherapy
Hydrazines/*pharmacology
Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors
Karyopherins/*antagonists & inhibitors
Osteosarcoma/*radiotherapy
Radiation Tolerance/*drug effects
Radiation-Sensitizing Agents/*pharmacology
Receptors, Cytoplasmic and Nuclear/*antagonists & inhibitors
Triazoles/*pharmacology
Apoptosis ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Bone Neoplasms/radiotherapy ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Karyopherins/genetics ; Karyopherins/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms/radiotherapy ; Osteosarcoma/drug therapy ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Mebhydrolin ameliorates glucose homeostasis in type 2 diabetic mice by functioning as a selective FXR antagonist.
Autorzy :
Zhao T; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Wang J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
He A; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Wang S; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Chen Y; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Lu J; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Lv J; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Li S; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Wang J; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Qian M; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
Li H; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: .
Shen X; School of Medicine& Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
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Źródło :
Metabolism: clinical and experimental [Metabolism] 2021 Jun; Vol. 119, pp. 154771. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbolines/*therapeutic use
Diabetes Mellitus, Type 2/*drug therapy
Glucose/*metabolism
Receptors, Cytoplasmic and Nuclear/*antagonists & inhibitors
Animals ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Carbolines/chemistry ; Carbolines/pharmacokinetics ; Cells, Cultured ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/metabolism ; Gluconeogenesis/drug effects ; Gluconeogenesis/genetics ; HEK293 Cells ; Homeostasis/drug effects ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Molecular Docking Simulation ; Protein Interaction Domains and Motifs ; Receptors, Cytoplasmic and Nuclear/chemistry ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Streptozocin
Czasopismo naukowe
Tytuł :
Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity relationship analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism.
Autorzy :
Gohda K; Computer-aided Molecular Modeling Research Center, Kansai (CAMM-Kansai), 3-32-302, Tsuto-Otsuka, Nishinomiya 663-8241, Japan. Electronic address: .
Iguchi Y; Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
Masuda A; Graduate School of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
Fujimori K; Department of Pathobiochemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Yamashita Y; Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
Teno N; Graduate School of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan; Faculty of Clinical Nutrition, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jun 01; Vol. 41, pp. 128026. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Molecular Dynamics Simulation*
Chenodeoxycholic Acid/*pharmacology
Receptors, Cytoplasmic and Nuclear/*agonists
Binding Sites/drug effects ; Chenodeoxycholic Acid/chemistry ; Dose-Response Relationship, Drug ; Humans ; Ligands ; Molecular Structure ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants.
Autorzy :
Guerrero GA; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Derisbourg MJ; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Mayr FA; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Wester LE; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Giorda M; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Dinort JE; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Hartman MD; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Schilling K; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Alonso-De Gennaro MJ; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Lu RJ; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, Los Angeles, United States.
Benayoun BA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, Los Angeles, United States.
Denzel MS; Max Planck Institute for Biology of Ageing, Cologne, Germany.; CECAD - Cluster of Excellence University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
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Źródło :
ELife [Elife] 2021 Aug 27; Vol. 10. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance*
Longevity*
ATP Binding Cassette Transporter, Subfamily B/*metabolism
Caenorhabditis elegans/*drug effects
Caenorhabditis elegans Proteins/*metabolism
Endoplasmic Reticulum Stress/*drug effects
Receptors, Cytoplasmic and Nuclear/*metabolism
Tunicamycin/*pharmacology
ATP Binding Cassette Transporter, Subfamily B/genetics ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Kinesin/genetics ; Kinesin/metabolism ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Mutation ; Receptors, Cytoplasmic and Nuclear/genetics ; Time Factors ; Tunicamycin/metabolism
Czasopismo naukowe
Tytuł :
Pathophysiology of reflux oesophagitis: role of Toll-like receptors 2 and 4 and Farnesoid X receptor.
Autorzy :
Nortunen M; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland. .; Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, Oulu, Finland. .; Department of Surgery, Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland. .
Väkiparta N; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland.
Porvari K; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland.
Saarnio J; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland.; Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, Oulu, Finland.; Department of Surgery, Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland.
Karttunen TJ; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland.
Huhta H; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland.; Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, Oulu, Finland.; Department of Surgery, Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Aug; Vol. 479 (2), pp. 285-293. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Esophageal Mucosa/*chemistry
Esophagitis, Peptic/*metabolism
Receptors, Cytoplasmic and Nuclear/*analysis
Toll-Like Receptor 2/*analysis
Toll-Like Receptor 4/*analysis
Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Case-Control Studies ; Esophageal Mucosa/immunology ; Esophagitis, Peptic/genetics ; Esophagitis, Peptic/immunology ; Female ; Humans ; Immunity, Innate ; Immunohistochemistry ; In Situ Hybridization ; Male ; Middle Aged ; Receptors, Cytoplasmic and Nuclear/genetics ; Severity of Illness Index ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Toxoplasma gondii UBL-UBA Shuttle Protein DSK2s Are Important for Parasite Intracellular Replication.
Autorzy :
Zhang H; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yang X; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Ying Z; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Liu J; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Liu Q; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 26; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Division*
Proteolysis*
Ubiquitination*
Protozoan Proteins/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Toxoplasma/*metabolism
Animals ; Gene Deletion ; Humans ; Mice ; Protozoan Proteins/genetics ; Receptors, Cytoplasmic and Nuclear/genetics ; Toxoplasma/genetics ; Toxoplasma/pathogenicity
Czasopismo naukowe
Tytuł :
Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury.
Autorzy :
Christidis G; Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Karatayli E; Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Hall RA; Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Weber SN; Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Reichert MC; Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Hohl M; Department of Medicine III, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Qiao S; Department of Pharmacology and Toxicology, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Boehm U; Department of Pharmacology and Toxicology, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Lütjohann D; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.
Lammert F; Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.; Hannover Health Sciences Campus, Hannover Medical School (MHH), 30625 Hannover, Germany.
Karatayli SC; Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 23; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B/*physiology
Acute-On-Chronic Liver Failure/*pathology
Bile Acids and Salts/*metabolism
Cholesterol 7-alpha-Hydroxylase/*metabolism
Fibroblast Growth Factors/*metabolism
Hepatocytes/*pathology
Receptors, Cytoplasmic and Nuclear/*metabolism
Acute-On-Chronic Liver Failure/metabolism ; Animals ; Case-Control Studies ; Cholesterol 7-alpha-Hydroxylase/genetics ; Female ; Fibroblast Growth Factors/genetics ; Hepatocytes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Cytoplasmic and Nuclear/genetics
Czasopismo naukowe
Tytuł :
Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.
Autorzy :
Willems S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany.
Zaienne D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany.
Merk D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 22; Vol. 64 (14), pp. 9592-9638. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Inflammation/*drug therapy
Neurodegenerative Diseases/*diagnosis
Neuroprotective Agents/*pharmacology
Receptors, Cytoplasmic and Nuclear/*antagonists & inhibitors
Animals ; Humans ; Inflammation/metabolism ; Ligands ; Molecular Structure ; Neurodegenerative Diseases/metabolism ; Neuroprotective Agents/chemistry ; Receptors, Cytoplasmic and Nuclear/metabolism
Czasopismo naukowe
Tytuł :
Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury.
Autorzy :
Petrescu AD; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
DeMorrow S; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.; Central Texas Veterans Health Care System, Temple, TX 78712, USA.
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Źródło :
Cells [Cells] 2021 Jul 21; Vol. 10 (8). Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Bile Acids and Salts/*metabolism
Cholestasis/*drug therapy
Gastrointestinal Agents/*therapeutic use
Liver/*drug effects
Liver Diseases/*drug therapy
Receptors, Cytoplasmic and Nuclear/*drug effects
Animals ; Autophagy/drug effects ; Cholestasis/complications ; Cholestasis/diagnosis ; Cholestasis/metabolism ; Gastrointestinal Agents/adverse effects ; Humans ; Ligands ; Liver/metabolism ; Liver/pathology ; Liver Diseases/diagnosis ; Liver Diseases/etiology ; Liver Diseases/metabolism ; Molecular Targeted Therapy ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.
Autorzy :
Herman AB; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Anerillas C; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Harris SC; Confocal Imaging Facility, Laboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Munk R; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Martindale JL; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Yang X; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Mazan-Mamczarz K; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Zhang Y; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Heckenbach IJ; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Scheibye-Knudsen M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark.
De S; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Sen P; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Abdelmohsen K; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7389-7405.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Cellular Senescence/*genetics
MicroRNAs/*metabolism
Receptors, Cytoplasmic and Nuclear/*genetics
Cell Line ; Cell Proliferation ; Cells, Cultured ; Cellular Senescence/drug effects ; Gene Expression Regulation ; Heterochromatin ; Humans ; Receptors, Cytoplasmic and Nuclear/metabolism
Czasopismo naukowe
Tytuł :
Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease.
Autorzy :
Paredes A; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Santos-Clemente R; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Ricote M; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 21; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cardiovascular Physiological Phenomena*
Gene Expression Regulation*
Cardiovascular Diseases/*pathology
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Humans ; Receptors, Cytoplasmic and Nuclear/genetics
Czasopismo naukowe
Tytuł :
Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.
Autorzy :
Zeng L; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
Li X; Biophotonics Research Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
Preusch CB; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
He GJ; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
Xu N; The MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China.
Cheung TH; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; Center for Stem Cell Research, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; State Key Laboratory in Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
Qu J; Biophotonics Research Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
Mak HY; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
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Źródło :
PLoS genetics [PLoS Genet] 2021 Jul 08; Vol. 17 (7), pp. e1009635. Date of Electronic Publication: 2021 Jul 08 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aldehyde Dehydrogenase/*genetics
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
Peroxisomes/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Aldehyde Dehydrogenase/chemistry ; Aldehyde Dehydrogenase/metabolism ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans Proteins/genetics ; Gene Expression Regulation ; Lipase/genetics ; Lipase/metabolism ; Lipid Droplets/metabolism ; Lipolysis/genetics ; Mutation ; Peroxisomes/genetics ; Receptors, Cytoplasmic and Nuclear/genetics
Czasopismo naukowe
Tytuł :
Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics.
Autorzy :
Helmstädter M; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Kaiser A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Brunst S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Schmidt J; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Ronchetti R; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Weizel L; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Proschak E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Merk D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 9525-9536. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzamides/*pharmacology
Enzyme Inhibitors/*pharmacology
Epoxide Hydrolases/*antagonists & inhibitors
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Benzamides/chemical synthesis ; Benzamides/chemistry ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Epoxide Hydrolases/metabolism ; Hep G2 Cells ; Humans ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear/genetics ; Structure-Activity Relationship
Czasopismo naukowe

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