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Wyszukujesz frazę ""Receptors, Estrogen"" wg kryterium: Temat


Tytuł :
Systemic Therapy for Estrogen Receptor-Positive, HER2-Negative Breast Cancer.
Autorzy :
Burstein HJ; From the Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School - all in Boston.
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Źródło :
The New England journal of medicine [N Engl J Med] 2020 Dec 24; Vol. 383 (26), pp. 2557-2570.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Breast Neoplasms/*drug therapy
Estrogen Receptor Antagonists/*therapeutic use
Receptors, Estrogen/*antagonists & inhibitors
Selective Estrogen Receptor Modulators/*therapeutic use
Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Chemotherapy, Adjuvant/adverse effects ; Estrogen Receptor Antagonists/adverse effects ; Female ; Humans ; Neoadjuvant Therapy ; Prognosis ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Selective Estrogen Receptor Modulators/adverse effects
Czasopismo naukowe
Tytuł :
A hypertension patient-derived iPSC model demonstrates a role for G protein-coupled estrogen receptor in hypertension risk and development.
Autorzy :
Fredette NC; Department of Pathology, Immunology and Experimental Medicine, University of Florida College of Medicine, Gainesville, Florida.
Malik E; Department of Pathology, Immunology and Experimental Medicine, University of Florida College of Medicine, Gainesville, Florida.
Mukhtar ML; Department of Mechanical & Aerospace Engineering, University of Florida Herbert Wertheim College of Engineering, Gainesville, Florida.
Prossnitz ER; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Terada N; Department of Pathology, Immunology and Experimental Medicine, University of Florida College of Medicine, Gainesville, Florida.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Nov 01; Vol. 319 (5), pp. C825-C838. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Endothelial Cells/*metabolism
Hypertension/*genetics
Induced Pluripotent Stem Cells/*metabolism
Receptors, Estrogen/*genetics
Receptors, G-Protein-Coupled/*genetics
Adult ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Base Sequence ; CRISPR-Cas Systems ; Cadherins/genetics ; Cadherins/metabolism ; Cell Adhesion ; Cell Differentiation ; Cell Engineering/methods ; Endothelial Cells/pathology ; Female ; Gene Editing/methods ; Gene Expression Regulation ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Induced Pluripotent Stem Cells/pathology ; Models, Biological ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Primary Cell Culture ; Receptors, Estrogen/deficiency ; Receptors, G-Protein-Coupled/deficiency ; Risk Factors ; THP-1 Cells ; von Willebrand Factor/genetics ; von Willebrand Factor/metabolism
Czasopismo naukowe
Tytuł :
Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway.
Autorzy :
Marroqui L; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Martinez-Pinna J; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain; Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.
Castellano-Muñoz M; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Dos Santos RS; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Medina-Gali RM; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Soriano S; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain; Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.
Quesada I; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Gustafsson JA; Department of Cell Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Encinar JA; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain.
Nadal A; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universitas Miguel Hernández, Elche, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Feb; Vol. 265, pp. 129051. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogen Receptor beta*/genetics
Estrogen Receptor beta*/metabolism
Receptors, Estrogen*/genetics
Animals ; Benzhydryl Compounds/toxicity ; Insulin ; Ion Channels ; Mice ; Phenols
Czasopismo naukowe
Tytuł :
The Future of ER+/HER2- Metastatic Breast Cancer Therapy: Beyond PI3K Inhibitors.
Autorzy :
Stravodimou A; Division of Medical Oncology, Centre Hospitalier Universiitaire Vaudois, Lausanne, Switzerland.
Voutsadakis IA; Algoma District Cancer Program, Sault Area Hospital, Sault Ste Marie, ON, Canada .; Section of Internal Medicine, Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada.
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Źródło :
Anticancer research [Anticancer Res] 2020 Sep; Vol. 40 (9), pp. 4829-4841.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
Receptor, ErbB-2/*metabolism
Receptors, Estrogen/*metabolism
Apoptosis/drug effects ; Breast Neoplasms/pathology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; Mutation ; Phosphatidylinositol 3-Kinases/metabolism ; Receptor, ErbB-2/antagonists & inhibitors ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, Estrogen/genetics ; Receptors, Fibroblast Growth Factor/antagonists & inhibitors ; Receptors, Fibroblast Growth Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause.
Autorzy :
Fan R; Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Kim YS; Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Wu J; University of Bern, Department of Chemistry and Biochemistry, Freiestrasse 3, 3012, Bern, Switzerland.
Chen R; Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Zeuschner D; Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Mildner K; Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Adachi K; Department for Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Wu G; Department for Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 6 Luoxuan Avenue, Haizhu District, 510320, Guangzhou, China.
Galatidou S; Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Li J; Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Schöler HR; Department for Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany.
Leidel SA; University of Bern, Department of Chemistry and Biochemistry, Freiestrasse 3, 3012, Bern, Switzerland.
Bedzhov I; Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149, Münster, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 30; Vol. 11 (1), pp. 5499. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diapause/*physiology
Embryonic Stem Cells/*metabolism
Receptors, Estrogen/*metabolism
Wnt Signaling Pathway/*physiology
Animals ; Embryonic Development ; Female ; Germ Layers/metabolism ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Morphogenesis ; Protein-Serine-Threonine Kinases/metabolism ; Receptors, Estrogen/genetics ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Machine Learning Models for Estrogen Receptor Bioactivity and Endocrine Disruption Prediction.
Autorzy :
Zorn KM; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Foil DH; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Lane TR; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Russo DP; Center for Computational and Integrative Biology, Rutgers University, Camden, New Jersey 08102, United States.
Hillwalker W; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Feifarek DJ; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Jones F; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Klaren WD; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Brinkman AM; Global Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Ekins S; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2020 Oct 06; Vol. 54 (19), pp. 12202-12213. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Endocrine Disruptors*/toxicity
Receptors, Estrogen*
Bayes Theorem ; Machine Learning ; Prospective Studies
Czasopismo naukowe
Tytuł :
Identifying oncogenic drivers associated with increased risk of late distant recurrence in postmenopausal, estrogen receptor-positive, HER2-negative early breast cancer: results from the BIG 1-98 study.
Autorzy :
Luen SJ; Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia.
Asher R; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney, Sydney, Australia.
Lee CK; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney, Sydney, Australia.
Savas P; Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia.
Kammler R; International Breast Cancer Study Group, Coordinating Center, Central Pathology Office, Bern, Switzerland.
Dell'Orto P; International Breast Cancer Study Group Central Pathology Office, Department of Pathology, IEO European Institute of Oncology IRCCS, Milan, Italy.
Biasi OM; Division of Pathology and Laboratory Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy.
Demanse D; Novartis Pharma AG, Basel, Switzerland.
Hackl W; OncogenomX Inc., Allschwil, Basel, Switzerland.
Thuerlimann B; Breast Center, Cantonal Hospital, St Gallen, Switzerland; Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland.
Viale G; Department of Pathology, University of Milan, Milan, Italy; IEO European Institute of Oncology IRCCS, Milan, Italy.
Di Leo A; Sandro Pitigliani Department of Medical Oncology, Hospital of Prato, Prato, Italy.
Colleoni M; Division of Medical Senology, European Institute of Oncology, Milan, Italy.
Regan MM; International Breast Cancer Study Group Statistical Center, Division of Biostatistics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
Loi S; Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia. Electronic address: .
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Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2020 Oct; Vol. 31 (10), pp. 1359-1365. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/epidemiology
Breast Neoplasms*/genetics
Class I Phosphatidylinositol 3-Kinases*/genetics
Receptors, Estrogen*/genetics
Chemotherapy, Adjuvant ; Humans ; Neoplasm Recurrence, Local/genetics ; Postmenopause ; Prognosis ; Randomized Controlled Trials as Topic ; Receptor, ErbB-2/genetics
Czasopismo naukowe
Tytuł :
Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4.
Autorzy :
Vernier M; Goodman Cancer Research Centre, McGill University, Montréal, H3A 1A3, QC, Canada. .
McGuirk S; Goodman Cancer Research Centre, McGill University, Montréal, H3A 1A3, QC, Canada.
Dufour CR; Goodman Cancer Research Centre, McGill University, Montréal, H3A 1A3, QC, Canada.
Wan L; Goodman Cancer Research Centre, McGill University, Montréal, H3A 1A3, QC, Canada.
Audet-Walsh E; Goodman Cancer Research Centre, McGill University, Montréal, H3A 1A3, QC, Canada.; Département de Médecine Moléculaire, Faculté de Médicine, Centre de Recherche du CHU de Québec, Université Laval, Québec, QC, G1V 4G2, Canada.
St-Pierre J; Goodman Cancer Research Centre, McGill University, Montréal, H3A 1A3, QC, Canada.; Departments of Biochemistry, Medicine and Oncology, Faculty of Medicine, McGill University, Montréal, H3G 1Y6, QC, Canada.; Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Giguère V; Goodman Cancer Research Centre, McGill University, Montréal, H3A 1A3, QC, Canada. .; Departments of Biochemistry, Medicine and Oncology, Faculty of Medicine, McGill University, Montréal, H3G 1Y6, QC, Canada. .
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Źródło :
Oncogene [Oncogene] 2020 Oct; Vol. 39 (41), pp. 6406-6420. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Breast Neoplasms/*genetics
DNA (Cytosine-5-)-Methyltransferase 1/*genetics
Interferon Regulatory Factors/*genetics
Receptors, Estrogen/*metabolism
Animals ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Line, Tumor ; CpG Islands/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA Methylation/drug effects ; Decitabine/pharmacology ; Decitabine/therapeutic use ; Epigenesis, Genetic/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice ; Promoter Regions, Genetic/genetics ; Protein Stability ; Receptors, Estrogen/antagonists & inhibitors ; S-Adenosylmethionine/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcription, Genetic/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
New Insights into Expression of Hormonal Receptors by Meningiomas.
Autorzy :
Portet S; Faculty of Medicine, University of Poitiers, Poitiers, France; Department of Neurosurgery, University Hospital of Poitiers, Poitiers, France. Electronic address: .
Banor T; Faculty of Medicine, University of Poitiers, Poitiers, France; Department of Neurosurgery, University Hospital of Poitiers, Poitiers, France.
Bousquet J; Faculty of Medicine, University of Poitiers, Poitiers, France; Department of Neurosurgery, University Hospital of Poitiers, Poitiers, France.
Simonneau A; Department of Neurosurgery, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Flores M; Faculty of Medicine, University of Poitiers, Poitiers, France; Department of Pathology, University Hospital of Poitiers, Poitiers, France.
Ingrand P; Faculty of Medicine, University of Poitiers, Poitiers, France; Department of Statistics, University Hospital of Poitiers, Poitiers, France.
Milin S; Faculty of Medicine, University of Poitiers, Poitiers, France; Department of Pathology, University Hospital of Poitiers, Poitiers, France.
Karayan-Tapon L; Faculty of Medicine, University of Poitiers, Poitiers, France; INSERM 1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France; Department of Cancer Biology, University Hospital of Poitiers, Poitiers, France.
Bataille B; Faculty of Medicine, University of Poitiers, Poitiers, France; Department of Neurosurgery, University Hospital of Poitiers, Poitiers, France.
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Źródło :
World neurosurgery [World Neurosurg] 2020 Aug; Vol. 140, pp. e87-e96. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Meningeal Neoplasms/*metabolism
Meningioma/*metabolism
Receptors, Androgen/*biosynthesis
Receptors, Estrogen/*biosynthesis
Receptors, Progesterone/*biosynthesis
Aged ; Cohort Studies ; Female ; Humans ; Male ; Meningeal Neoplasms/genetics ; Meningeal Neoplasms/pathology ; Meningioma/genetics ; Meningioma/pathology ; Middle Aged ; Receptors, Androgen/genetics ; Receptors, Estrogen/genetics ; Receptors, Progesterone/genetics
Czasopismo naukowe
Tytuł :
Effects of estrogen receptor signaling on prostate cancer carcinogenesis.
Autorzy :
Qu LG; Eastern Health Clinical School, Monash University, Victoria, Australia. Electronic address: .
Wardan H; Eastern Health Clinical School, Monash University, Victoria, Australia.
Davis ID; Eastern Health Clinical School, Monash University, Victoria, Australia; Department of Oncology, Eastern Health, Victoria, Australia.
Pezaro C; Eastern Health Clinical School, Monash University, Victoria, Australia; Department of Oncology, Eastern Health, Victoria, Australia.
Sluka P; Eastern Health Clinical School, Monash University, Victoria, Australia.
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Źródło :
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2020 Aug; Vol. 222, pp. 56-66. Date of Electronic Publication: 2020 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Signal Transduction*
Carcinogenesis/*metabolism
Prostatic Neoplasms/*metabolism
Receptors, Estrogen/*metabolism
Humans ; Liquid Biopsy ; Male ; RNA Splicing/genetics ; Receptors, Estrogen/genetics
Czasopismo naukowe
Tytuł :
Distinct Function of Estrogen Receptors in the Rodent Anterior Cingulate Cortex in Pain-related Aversion.
Autorzy :
Zang KK; From the State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Institutes of Brain Science, Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China (K.-K.Z., L.-Q.C., Y.Y., Q.-L.C., Y.-L.T., S.-S.L., H.C., Y.-Q.Z.) the Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China (X.X.) the First Rehabilitation Hospital of Shanghai, Tongji University School of Medicine, Shanghai 200090, China (L.Z.).
Xiao X
Chen LQ
Yang Y
Cao QL
Tang YL
Lv SS
Cao H
Zhang L
Zhang YQ
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Źródło :
Anesthesiology [Anesthesiology] 2020 Jul; Vol. 133 (1), pp. 165-184.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Estrogen*/drug effects
Receptors, Estrogen*/genetics
Gyrus Cinguli/*physiopathology
Pain/*physiopathology
Pain/*psychology
Animals ; Avoidance Learning ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic GMP-Dependent Protein Kinases/genetics ; Cyclic GMP-Dependent Protein Kinases/metabolism ; Estrogen Antagonists/pharmacology ; Estrogen Receptor beta/drug effects ; Estrogen Receptor beta/genetics ; Excitatory Postsynaptic Potentials/drug effects ; Female ; Gene Knockdown Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Patch-Clamp Techniques ; RNA, Small Interfering ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Estrogen receptor-mediated targeting of the extracellular matrix network in cancer.
Autorzy :
Piperigkou Z; Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, 26110, Greece; Foundation for Research and Technology-Hellas (FORTH)/Institute of Chemical Engineering Sciences (ICE-HT), Patras, 26110, Greece. Electronic address: .
Karamanos NK; Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, 26110, Greece; Foundation for Research and Technology-Hellas (FORTH)/Institute of Chemical Engineering Sciences (ICE-HT), Patras, 26110, Greece. Electronic address: .
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Źródło :
Seminars in cancer biology [Semin Cancer Biol] 2020 May; Vol. 62, pp. 116-124. Date of Electronic Publication: 2019 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Extracellular Matrix/*metabolism
Neoplasms/*etiology
Neoplasms/*metabolism
Receptors, Estrogen/*metabolism
Animals ; Biomarkers, Tumor ; Disease Management ; Disease Progression ; Disease Susceptibility ; Extracellular Matrix/drug effects ; Humans ; Molecular Targeted Therapy ; Neoplasms/pathology ; Neoplasms/therapy ; Precision Medicine ; Prognosis ; Protein Binding ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, Estrogen/chemistry ; Signal Transduction/drug effects ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Scaffold attachment factor B: distribution and interaction with ERα in the rat brain.
Autorzy :
Hashimoto T; Department of Pharmacology, Graduate School of Medicine, Aichi Medical University, Aichi, Japan.
Kawata M; School of Health Sciences, Bukkyo University, Kyoto, Japan.
Hirahara Y; Department of Anatomy and Cell Science, Kansai Medical University, Osaka, Japan.
Nishi M; Department of Anatomy and Cell Biology,, Nara Medical University, Nara, Japan.
Satoshi I; Division of Anatomy, Department of Morphological and Physiological Science, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Matsuda KI; Department of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. .
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Źródło :
Histochemistry and cell biology [Histochem Cell Biol] 2020 May; Vol. 153 (5), pp. 323-338. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Estrogen Receptor alpha/*chemistry
Matrix Attachment Region Binding Proteins/*analysis
Nuclear Matrix-Associated Proteins/*analysis
Receptors, Estrogen/*analysis
Animals ; Cells, Cultured ; Estrogen Receptor alpha/metabolism ; Female ; Male ; Matrix Attachment Region Binding Proteins/deficiency ; Matrix Attachment Region Binding Proteins/metabolism ; Nuclear Matrix-Associated Proteins/deficiency ; Nuclear Matrix-Associated Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptors, Estrogen/deficiency ; Receptors, Estrogen/metabolism
Czasopismo naukowe
Tytuł :
Reduced PAX2 expression in murine fallopian tube cells enhances estrogen receptor signaling.
Autorzy :
Colina JA; Pharmaceutical Sciences, Center for Biomolecular Science, University of Illinois at Chicago, Chicago, IL, USA.
Varughese P; Pharmaceutical Sciences, Center for Biomolecular Science, University of Illinois at Chicago, Chicago, IL, USA.
Karthikeyan S; Pharmaceutical Sciences, Center for Biomolecular Science, University of Illinois at Chicago, Chicago, IL, USA.
Salvi A; Pharmaceutical Sciences, Center for Biomolecular Science, University of Illinois at Chicago, Chicago, IL, USA.
Modi DA; Pharmaceutical Sciences, Center for Biomolecular Science, University of Illinois at Chicago, Chicago, IL, USA.
Burdette JE; Pharmaceutical Sciences, Center for Biomolecular Science, University of Illinois at Chicago, Chicago, IL, USA.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (5), pp. 646-655.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelium/*pathology
Estrogens/*metabolism
Fallopian Tube Neoplasms/*pathology
Fallopian Tubes/*pathology
PAX2 Transcription Factor/*antagonists & inhibitors
Receptors, Estrogen/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Cycle ; Cell Movement ; Cell Proliferation ; Disease Models, Animal ; Epithelium/drug effects ; Epithelium/metabolism ; Fallopian Tube Neoplasms/drug therapy ; Fallopian Tube Neoplasms/genetics ; Fallopian Tube Neoplasms/metabolism ; Fallopian Tubes/drug effects ; Fallopian Tubes/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; PAX2 Transcription Factor/genetics ; PAX2 Transcription Factor/metabolism ; Receptors, Estrogen/genetics ; Signal Transduction ; Transcriptome ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Hormone receptor, human epidermal growth factor receptor-2, and Ki-67 status in primary breast cancer and corresponding recurrences or synchronous axillary lymph node metastases.
Autorzy :
Yamanouchi K; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. .
Kuba S; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Eguchi S; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
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Źródło :
Surgery today [Surg Today] 2020 Jul; Vol. 50 (7), pp. 657-663. Date of Electronic Publication: 2019 Jun 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Axilla*
Lymphatic Metastasis*
Neoplasm Recurrence, Local*
Biomarkers, Tumor/*metabolism
Breast Neoplasms/*diagnosis
Breast Neoplasms/*genetics
Ki-67 Antigen/*metabolism
Receptor, ErbB-2/*metabolism
Receptors, Estrogen/*metabolism
Receptors, Progesterone/*metabolism
Biomarkers, Tumor/genetics ; Breast Neoplasms/pathology ; Female ; Gene Expression ; Humans ; Ki-67 Antigen/genetics ; Prognosis ; Receptor, ErbB-2/genetics ; Receptors, Estrogen/genetics ; Receptors, Progesterone/genetics
Czasopismo naukowe
Tytuł :
ERRα Expression in Bone Metastases Leads to an Exacerbated Antitumor Immune Response.
Autorzy :
Bouchet M; INSERM-UMR1033, Labex DEVweCAN, Lyon, France.; University of Lyon-France.
Lainé A; University of Lyon-France.; Tumor Escape Resistance and Immunity Department, CRCL, INSERM 1052 CNRS 5286, Centre Léon Bérard, Labex DEVweCAN, Lyon, France.
Boyault C; Institute for Advanced Biosciences, UMR5209-INSERM1302, La Tronche, France.
Proponnet-Guerault M; Institute for Advanced Biosciences, UMR5209-INSERM1302, La Tronche, France.
Meugnier E; INSERMU1060-INRA-U1397, Lyon, France.
Bouazza L; INSERM-UMR1033, Labex DEVweCAN, Lyon, France.; University of Lyon-France.
Kan CWS; INSERM-UMR1033, Labex DEVweCAN, Lyon, France.; University of Lyon-France.
Geraci S; INSERM-UMR1033, Labex DEVweCAN, Lyon, France.; University of Lyon-France.
El-Moghrabi S; INSERM-UMR1033, Labex DEVweCAN, Lyon, France.; University of Lyon-France.
Hernandez-Vargas H; Tumor Escape Resistance and Immunity Department, CRCL, INSERM 1052 CNRS 5286, Centre Léon Bérard, Labex DEVweCAN, Lyon, France.
Benetollo C; University of Lyon-France.; INSERM-UMR5292 INSERM U1028, Lyon, France.
Yoshiko Y; Department of Calcified Tissue Biology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
Duterque-Coquillaud M; University of Lille, Institut Pasteur de Lille, CNRS-UMR9020-INSERM-UMR1277, Lille, France.
Clézardin P; INSERM-UMR1033, Labex DEVweCAN, Lyon, France.; University of Lyon-France.
Marie JC; University of Lyon-France. .; Tumor Escape Resistance and Immunity Department, CRCL, INSERM 1052 CNRS 5286, Centre Léon Bérard, Labex DEVweCAN, Lyon, France.
Bonnelye E; INSERM-UMR1033, Labex DEVweCAN, Lyon, France. .; University of Lyon-France.
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Źródło :
Cancer research [Cancer Res] 2020 Jul 01; Vol. 80 (13), pp. 2914-2926. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor/*metabolism
Bone Neoplasms/*prevention & control
Breast Neoplasms/*prevention & control
Receptors, Estrogen/*metabolism
T-Lymphocytes/*immunology
Tumor Microenvironment/*immunology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Bone Neoplasms/immunology ; Bone Neoplasms/metabolism ; Bone Neoplasms/secondary ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Chemokine CCL17/genetics ; Chemokine CCL17/metabolism ; Chemokine CCL20/genetics ; Chemokine CCL20/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Receptors, Estrogen/genetics ; Signal Transduction ; Transforming Growth Factor beta3/genetics ; Transforming Growth Factor beta3/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
G protein-coupled estrogen receptor, a potential therapeutic target of asthma probed by Chinese herb.
Autorzy :
Xu YD; Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yang YQ; Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zheng YJ; Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Jul; Vol. 108 (1), pp. 13-16. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Asthma*/drug therapy
Receptors, Estrogen*
Estrogens ; Flavonoids ; Humans ; Inflammation ; Receptors, G-Protein-Coupled
Raport
Tytuł :
Anticancer Melatplatin Prodrugs: High Effect and Low Toxicity, MT1-ER-Target and Immune Response In Vivo .
Autorzy :
Song XQ; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Liu RP; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Wang SQ; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Li Z; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Ma ZY; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Zhang R; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Xie CZ; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Qiao X; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Xu JY; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jun 11; Vol. 63 (11), pp. 6096-6106. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Platinum/*chemistry
Prodrugs/*chemistry
Receptor, Melatonin, MT1/*metabolism
Receptors, Estrogen/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Binding Sites ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Damage/drug effects ; Humans ; Immune System/drug effects ; Immune System/metabolism ; Mice ; Mice, Nude ; Molecular Docking Simulation ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Protein Structure, Tertiary ; Receptor, Melatonin, MT1/chemistry ; Receptors, Estrogen/chemistry
Czasopismo naukowe
Tytuł :
SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts.
Autorzy :
Hutter K; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Lohmüller M; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Jukic A; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Eichin F; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Avci S; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Labi V; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Szabo TG; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Hoser SM; Institute for Genomics and RNomics, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Hüttenhofer A; Institute for Genomics and RNomics, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria.
Villunger A; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria.
Herzog S; Institute of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jun 04; Vol. 78 (5), pp. 876-889.e6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Matrix Attachment Region Binding Proteins/*metabolism
MicroRNAs/*metabolism
Nuclear Matrix-Associated Proteins/*metabolism
Receptors, Estrogen/*metabolism
Animals ; Cell Line ; Cell Nucleus/metabolism ; HEK293 Cells ; Humans ; Inverted Repeat Sequences/genetics ; Inverted Repeat Sequences/physiology ; Matrix Attachment Region Binding Proteins/genetics ; Mice ; MicroRNAs/genetics ; Nuclear Matrix-Associated Proteins/genetics ; Nucleic Acid Conformation ; RNA Processing, Post-Transcriptional/genetics ; RNA-Binding Proteins/metabolism ; Receptors, Estrogen/genetics
Czasopismo naukowe
Tytuł :
Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30.
Autorzy :
Schmidt-Wolf R; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany .
Zissel G; Department of Pneumology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2020 Jun; Vol. 40 (6), pp. 3097-3108.
Typ publikacji :
Journal Article
MeSH Terms :
Chemokines, CC/*metabolism
Estradiol/*metabolism
Matrix Metalloproteinase 7/*metabolism
Receptors, Estrogen/*metabolism
Receptors, G-Protein-Coupled/*metabolism
A549 Cells ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Chemokines, CC/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/metabolism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; MCF-7 Cells ; Matrix Metalloproteinase 7/biosynthesis ; Matrix Metalloproteinase 7/genetics ; Phosphorylation ; RNA, Long Noncoding/biosynthesis ; RNA, Long Noncoding/genetics ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Signal Transduction
Czasopismo naukowe

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